adenosine diphosphate has been researched along with thromboxane a2 in 328 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 115 (35.06) | 18.7374 |
| 1990's | 96 (29.27) | 18.2507 |
| 2000's | 73 (22.26) | 29.6817 |
| 2010's | 43 (13.11) | 24.3611 |
| 2020's | 1 (0.30) | 2.80 |
| Authors | Studies |
|---|---|
| Chignard, M; Vargaftig, BB | 1 |
| Cagle, WD; Lord, J; Lucky, W; Maruta, H; Ziboh, VA | 1 |
| Gerrard, JM; White, JG | 1 |
| Gorman, RR; Miller, OV; Wierenga, W | 1 |
| Enke, SE; Halushka, PV; Le Breton, GC; Venton, DL | 1 |
| Chytkowski, A; Dembinska-Kiec, A; Gryglewski, RJ; Zmuda, A | 1 |
| Grodzińska, L; Marcinkiewicz, E | 1 |
| Harada, Y; Katori, M; Tanaka, K | 1 |
| Benveniste, J; Chignard, M; Le Couedic, JP; Tence, M; Vargaftig, BB | 1 |
| Joist, JH; Minkes, MS; Needleman, P | 1 |
| Abiko, Y; Ashida, SI | 1 |
| Holmsen, H; Meyers, KM; Prieur, DJ; Seachord, CL; Smith, JB | 1 |
| Mashimo, N; Mitani, J; Numano, F; Sakurada, H; Watanabe, Y; Yamaguchi, S | 1 |
| Barton, PG | 1 |
| Lüscher, EF | 1 |
| Heemskerk, JW; Sage, SO | 1 |
| David, M; Griesmacher, A; Horvath, G; Mueller, MM; Weigel, G | 1 |
| Fitscha, P; O'Grady, J; Rauscha, F; Sinzinger, H; Virgolini, I | 1 |
| Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Mayhan, WG | 1 |
| Dieter, JP; Knezevic, I; Le Breton, GC | 1 |
| Barrow, DV; Gross, PL; Packham, MA; Rand, ML | 2 |
| Boucheix, C; Carroll, RC; Rubinstein, E; Urso, I | 1 |
| Griesmacher, A; Müller, MM; Weigel, G | 1 |
| Huang, TF; Sheu, JR; Teng, CM | 1 |
| Aznar, J; Broekman, MJ; Marcus, AJ; Martinez-Sales, V; Portoles, M; Safier, LB; Santos, MT; Valles, J | 1 |
| Buzzi, E; Colao, C; Leoncini, G; Maresca, M; Mazzei, M | 1 |
| Anderson, HV; Benedict, CR; Buja, LM; Campbell, WB; Cui, K; Maffrand, JP; McNatt, J; Ober, JC; Rosolowsky, M; Yao, SK | 1 |
| Jimenez, AH; Muller, JE; Stubbs, ME; Tofler, GH; Williams, GH; Winther, K | 1 |
| Glusa, E | 1 |
| Cahill, BE; Haile, DM; Kadowitz, PJ; Neely, CF | 1 |
| Hirano, K; Mizuno, A; Nagashima, S; Nakashima, M; Uematsu, T | 1 |
| Leira, R | 1 |
| Brown, BR; Hall, SE; Han, WC; Harris, DN; Hedberg, A; Misra, RN; Webb, ML | 1 |
| Speiser-Ellerton, S; Weiss, HJ | 1 |
| Pinto, A; Sorrentino, L; Sorrentino, R | 1 |
| Kambayashi, J; Kawasaki, T; Mori, T; Sakon, M; Shiba, E; Uemura, Y | 1 |
| Furui, H; Furumichi, T; Hayashi, H; Saito, H; Suzuki, T; Yamada, Y; Yamauchi, K; Yokota, M | 1 |
| Higashihara, M; Kariya, T; Kume, S; Matsumoto, Y; Ozaki, Y; Yatomi, Y | 1 |
| Lumley, P; Thomas, M | 1 |
| Colman, RW | 2 |
| Derian, CK; Friedman, PA; Gould, RJ | 1 |
| Huang, TF; Ko, FN; Liu, YM; Sheu, SJ; Teng, CM | 1 |
| Heyns, AD; van Wyk, V | 1 |
| Bochner, F; Duncan, EM; Lloyd, JV; Siebert, DM; Somogyi, AA; Wilson, KM | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Vickers, JD | 1 |
| Fujiwara, M; Kurahashi, K; Shimaji, H; Shirahase, H; Usui, H | 1 |
| Akada, S; Hisanaga, H; Ichijo, M; Iioka, H; Morimoto, K; Moriyama, I | 1 |
| Boucheix, C; Carroll, RC; Worthington, RE | 1 |
| Chao, BH; Harker, LA; Maraganore, JM; Marzec, UM; Ruggeri, ZM; Savage, B | 1 |
| Brace, LD; Le Breton, GC; Venton, DL | 2 |
| Avdonin, PV; Bochkov, VN; Cheglakov, IB; Tkachuk, VA | 1 |
| Barradas, MA; Dandona, P; Hoffbrand, AV; Jeremy, JY; Kontoghiorghes, GJ; Mikhailidis, DP | 1 |
| Caprino, L; Gallozzi, S; Togna, G | 1 |
| Arosio, E; Guzzo, P; Lechi, A; Lechi, C; Minuz, P; Paluani, F; Sinigaglia, D | 1 |
| Fujimoto, T; Fukushima, Y; Suzuki, H; Tanoue, K; Yamazaki, H | 1 |
| Matsuoka, I; Nakahata, N; Nakanishi, H; Ono, T | 1 |
| Gerrard, JM; MacIntyre, DE; McNicol, A | 1 |
| Bondy, GS; Gentry, PA | 1 |
| Folie, BJ; McIntire, LV | 1 |
| Kakushi, H; Shike, T; Uchida, K | 1 |
| Papatheofanis, FJ | 1 |
| Domogatsky, SP; Leytin, VL; Lyubimova, EV; Misselwitz, F | 1 |
| Akesson, B; Thorngren, M | 1 |
| Goldenberg, HJ; Harris, DN; Heran, CL; Michel, IM; Ogletree, ML; Phillips, MB | 1 |
| Armstrong, ML; Heistad, DD; Lopez, JA; Piegors, DJ | 1 |
| Fujimoto, T; Suzuki, H; Tanoue, K; Yamazaki, H | 1 |
| Ambler, J; Birch, J; Maguire, ED; Wallis, RB | 1 |
| Bush, LR; Smith, SG | 1 |
| Betteridge, DJ; Dandona, P; Hendra, TJ; Jeremy, JY; Oughton, J; Smith, CC; Yudkin, JS | 1 |
| Bauman, JE; Joist, JH; Lagunoff, D; Martin, TW | 1 |
| Eldor, A; Heyns, Adu P; Marx, G; Yarom, R | 1 |
| Halushka, PV; Kochel, PJ; Mais, DE; Saussy, DL | 1 |
| Aron, L; Hertzeanu, H; Platsker, J | 1 |
| Garber, DP; Greenberg, R; Harris, DN; Haslanger, MF; Nakane, M; Ogletree, ML; Reid, JA | 1 |
| Francis, GS; Johnson, GJ; Leis, LA | 1 |
| Inagaki, M; Meguro, T; Miura, T; Okada, Y; Saito, N; Taki, M; Tomita, Y; Tsuda, Y; Yamada, K | 1 |
| Hallam, TJ; O'Connor, N; Rink, TJ; Simpson, AW | 1 |
| Moncada, S; Whittle, BJ | 1 |
| Armstrong, RA; Jones, RL; Wilson, NH | 1 |
| Bushfield, M; MacIntyre, DE; MacMillan, LJ; McNicol, A; Moffat, KJ; Murdoch, FA; Rossi, AG; Thomson, A | 1 |
| Dandona, P; Gisinger, C; Jeremy, J; Mikhailidis, D; Schernthaner, G; Speiser, P | 1 |
| Emms, H; Lewis, GP | 1 |
| Bonner, FW; Eason, CT; Pattison, A | 1 |
| Calder, AA; Forbes, CD; Greer, IA; McLaren, M; Walker, JJ | 1 |
| Bowie, EJ; Chesebro, JH; Lam, JY; Shimokawa, H; Vanhoutte, PM | 1 |
| Hara, H; Inoue, T; Kakushi, H; Maruyama, T; Mihara, S; Okabayashi, T; Shike, T; Shirai, D; Takeda, Y; Uchida, K | 1 |
| Andries, R; Bourgain, RH; Braquet, P; Decuyper, K | 1 |
| Hamasaki, Y; Ichimaru, T; Miyazaki, S; Tasaki, H | 1 |
| Balduini, CL; Bertolino, G; Bisio, A; Noris, P; Sinigaglia, F; Torti, M | 1 |
| Corrigan, JJ; Fenster, PE; Ring, ME | 2 |
| Barradas, MA; Dandona, P; De Souza, V; Jeremy, JY; Mikhailidis, DP; Wakeling, A | 1 |
| Shepherd, JT; Vanhoutte, PM | 1 |
| Zahavi, J; Zahavi, M | 1 |
| Liakishev, AA; Mazurov, AV; Repin, VS; Sidorenko, BA; Sinitsyn, VE | 1 |
| Schrör, K; Verheggen, R | 1 |
| Hubbell, JA; McIntire, LV | 1 |
| Amroian, EA; Chursina, IuIa; Khudaverdian, DN | 1 |
| Chambers, JK; Colwell, JA; Halushka, PV; Loadholt, CB; Lopes-Virella, M; Mayfield, RK; Wohltmann, HJ | 1 |
| Carter, AJ; Heptinstall, S | 1 |
| Harada, Y; Katori, M | 1 |
| Hall, ER; Pan, IQ; Wu, KK | 1 |
| Darcet, P; Dechavanne, M; Driss, F; Lagarde, M; Vericel, E | 1 |
| D'Angelo, A; Galli, G; Mannucci, PM; Pareti, FI; Sautebin, L; Smith, JB | 1 |
| Hornstra, G | 1 |
| Born, GV; Shafi, S; Thorngren, M | 1 |
| Benveniste, J; Fouque, F; Joseph, D; Odiot, J; Vargaftig, BB | 1 |
| Passa, P; Paton, RC | 1 |
| Birgens, HS; Hansen, MS | 1 |
| Gorman, RR | 1 |
| Ghali, NI; Hung, SC; Le Breton, GC; Venton, DL | 1 |
| Le Breton, GC; Parise, LV; Venton, DL | 2 |
| Borda, ES; Gimeno, AL; Gimeno, MF; Lazzari, MA; Sterin-Borda, L | 1 |
| Honn, KV; Onoda, JM; Sloane, BF | 1 |
| Nakamizo, N; Shuto, K; Yamada, K | 1 |
| Catalano, PM; De Marco, L; Di Minno, G; Murphy, S; Shapiro, SS | 1 |
| Brigmon, L; Mehta, J; Mehta, P; Ostrowski, N | 1 |
| Barradas, MA; Dandona, P; Green, N; Jeremy, JY; Mikhailidis, DP | 1 |
| Chan, CC; Ford-Hutchinson, AW; Hall, RA; Nathaniel, DJ; Yusko, PJ | 1 |
| Holmsen, H; Rao, AK; Willis, J | 1 |
| Broekman, MJ; Kaplan, KL; Marcus, AJ; Safier, LB; Ullman, HL; Weksler, BB; Wong, KT | 1 |
| Gachályi, B; Káldor, A; Tihanyi, K; Vas, A | 1 |
| Colman, RW; Rao, AK; Sinha, AK; Willis, J | 1 |
| Colman, RW; Sinha, AK | 1 |
| Eldor, A; Floman, Y; Liebergall, M; Robin, GC | 1 |
| Kangasaho, M; Vapaatalo, H | 1 |
| Mehta, J; Mehta, P; Ostrowski, N | 1 |
| Brain, MC; Neame, PB | 1 |
| Antonetti, F; Borrelli, F; Caprino, L; Morelli, L | 1 |
| Neri Serneri, GG | 1 |
| Benveniste, J; Chignard, M; Le Couedic, JP; Vargaftig, BB | 1 |
| Aharony, D; Pilo, R; Raz, A | 1 |
| Cornwell, DG; Karpen, CW; Merola, AJ; Panganamala, RV; Trewyn, RW | 1 |
| Harris, RH; Nichols, R; Ramwell, PW; Schmeling, JW | 1 |
| Lewis, GP; Watts, IS | 1 |
| Basista, M; Bieron, K; Dembinska-Kiec, A; Grodzinska, L; Kedzior, A; Kostka-Trabka, E; Telesz, E; Zelazny, T; Zmuda, A | 1 |
| Andries, R; Bourgain, RH; Deby, C; Deby-Dupont, G | 1 |
| Nordøy, A | 1 |
| Caen, J; Drouet, L; Tobelem, G | 1 |
| Araki, H; Lefer, AM; Smith, JB | 1 |
| Chignard, M; Lefort, J; Marlas, G; Prado-Franceschi, J; Vargaftig, BB | 1 |
| Frishman, WH | 1 |
| Fiedel, BA; Izzi, JM; Prancan, A; Simpson, RM | 1 |
| Feller, DR; Mayo, JR; Miller, DD; Navran, SS | 1 |
| Anderson, WH; Chuang, HY; Mason, RG; Mohammad, SF; Smith, JB | 1 |
| Bussolino, F; Caligaris Cappio, F; Camussi, G; Coda, R; Masera, C; Segoloni, G; Tetta, C | 1 |
| Agnelli, G; Callegari, P; Hauert, J; Iorio, A; Parise, P | 1 |
| Armstrong, R; Heptinstall, S; Lösche, W; May, JA | 1 |
| Hatano, Y; Hirakata, H; Mori, K; Nakamura, K; Narumiya, S; Ushikubi, F | 1 |
| Brodsky, I; Devlin, TM; McKenzie, RJ; Soslau, G | 1 |
| Barnard, MR; Bednarek, FJ; Ellis, PA; Kestin, AS; Michelson, AD; Rajasekhar, D | 1 |
| Chern, JW; Chou, TC; Ding, YA; Yen, MH | 1 |
| Antunes, E; de Nucci, G; Dietrich, CP; Donato, JL; Marcondes, S; Nader, HB; Nogueira, MD | 1 |
| Daniel, JL; Gazzaniga, PP; Pulcinelli, FM; Riondino, S; Salganicoff, L | 1 |
| Bell, DR; Koritnik, DR; Koshy, A; Rensberger, HJ | 1 |
| Evans, RJ; Hayes, LJ; Heath, MF; Littler, RM; McEvoy, RJ; Poole, AW | 1 |
| Astarie-Dequeker, C; Devynck, MA; Korichneva, I | 1 |
| Edelman, ER; Friedman, M; Grossman, W; Harada, K; Sellke, FW; Simons, M; Wang, SY | 1 |
| Hirata, Y; Nakano, M; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Castiglioni, C; Gazzaniga, PP; Parisi, S; Pignatelli, P; Pulcinelli, FM; Riondino, S | 1 |
| Alagon, A; Donner, P; Haendler, B; Krätzschmar, J; Noeske-Jungblut, C; Possani, L; Schleuning, WD; Verhallen, P | 1 |
| Brooks, RM; Heistad, DD; Kaul, S; Padgett, RC; Waack, BJ | 1 |
| Brass, LF; Hoxie, JA; Kieber-Emmons, T; Manning, DR; Poncz, M; Woolkalis, M | 1 |
| Anderson, HV; Buja, LM; Cui, K; Maffrand, JP; McNatt, J; Willerson, JT; Yao, SK | 1 |
| Geiger, J; Walter, U | 1 |
| Campagnoli, C; Crosignani, PG; Gatti, L; Gianotti, GA; Guarneri, D; Nicolini, U | 1 |
| Dai, HB; Friedman, M; Johnson, RG; Schoen, FJ; Sellke, FW; Shafique, T; Weintraub, RM | 1 |
| Juliano, D; Kowalska, MA; Lu, W; Niewiarowski, S; Trybulec, M | 1 |
| Boulanger, CM; Mombouli, JV; Vanhoutte, PM | 1 |
| Arabe, L; Parker, J; Pelleg, A; Soslau, G | 1 |
| Cerletti, C; de Gaetano, G; Di Lallo, M; Martelli, N; Molino, M | 1 |
| Akkerman, JW; Bruijnzeel, PL; Burgers, JA; Koenderman, L; Schweizer, RC | 1 |
| Duncan, EM; Lloyd, JV; Tunbridge, LJ | 1 |
| Hirata, Y; Matsuno, H; Nakashima, M; Takiguchi, Y; Uematsu, T; Umemura, K; Wada, K | 1 |
| Cazenave, JP; Gachet, C; Laugwitz, KL; Nürnberg, B; Ohlmann, P; Schultz, G; Spicher, K | 1 |
| Dickinson, JP; Glenn, JR; Heptinstall, S; May, JA; Sanderson, HM; Wilcox, RG | 1 |
| Dangelmaier, C; Smith, JB; Zhou, Q | 1 |
| FitzGerald, GA; Praticò, D; Smyth, EM; Violi, F | 1 |
| Li, J; Schoen, FJ; Sellke, FW; Stamler, A; Thurer, RL; Wang, SY | 1 |
| Colman, RW; Puri, RN | 1 |
| Heptinstall, S; Lösche, W; Sanderson, HM; Vickers, J | 1 |
| Frölich, JC; Tsikas, D; Viigimaa, M | 1 |
| Chiu, L; Faung, ST; Wang, CT | 1 |
| Lai, PS; Rodriguez, A; Spur, BW; Wong, PY; Yin, K | 1 |
| Anogianakis, G; Barbacane, RC; Conti, P; De Fazio, P; Di Febbo, C; Dimitriadou, D; Frydas, S; Placido, FC; Porreca, E; Reale, M; Trakatellis, A; Vacalis, D | 1 |
| Hatano, Y; Hirakata, H; Mori, K; Nakamura, K; Narumiya, S; Sai, S; Toda, H; Urabe, N; Ushikubi, F | 1 |
| Fratantoni, JC; Mondoro, TH; Shafer, B; Vostal, JG | 1 |
| Caccamo, ML; Gatti, L; Gianotti, GA; Guarneri, D; Marini, A | 1 |
| Soslau, G; Youngprapakorn, D | 1 |
| Fein, A; Kapural, L | 1 |
| Cattaneo, M; Cazenave, JP; Gachet, C; Lombardi, R; Mannucci, PM; Ohlmann, P; Zighetti, ML | 1 |
| Akiba, K; Hayasaka, K; Katsuura, M; Mitsui, T; Shimizu, Y; Yokoyama, S | 1 |
| Batey, AJ; Coker, SJ; Shaw, LA | 1 |
| Brockbank, KG; Hansen, TN | 1 |
| Carroll, RC; Kouns, WC; Lanza, F; Steiner, B; Wang, XF | 1 |
| Gilani, AH; Majoo, RU; Saeed, SA; Shah, BH | 1 |
| Aoki, T; Honda, S; Okubo, M; Seki, J; Senzaki, K; Takahashi, F; Takasugi, H; Tanaka, A; Tomiyama, Y | 1 |
| Bode-Böger, SM; Böger, RH; Böhme, M; Frölich, JC; Kienke, S; Phivthong-ngam, L; Tsikas, D | 1 |
| Hornstra, G; Mensink, RP; Temme, EH | 1 |
| Coffman, TM; Hoffman, M; Koller, BH; Latour, A; Mannon, PJ; Mannon, RB; Oliver, JA; Smithies, O; Thomas, DW | 1 |
| Bellisola, G; Guidi, GC; Perona, G; Ricetti, MM; Rigo, A; Tecchio, C | 1 |
| Lynch, K; Moss, HB; Yao, JK | 1 |
| Nguyen, A; Packham, MA; Rand, ML | 1 |
| Fukuuchi, Y; Inoue, K; Schiszler, I; Tanahashi, N; Tomita, M; Tomita, Y; Yokoyama, M | 1 |
| Li, BY; Li, WH; Qiao, GF; Wang, L; Zhou, H | 1 |
| Humphries, RG; Jarvis, GE; Leff, P; Robertson, MJ | 1 |
| Dangelmaier, C; Daniel, JL; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Andersen, J; Champagne, D; Francischetti, IM; Ribeiro, JM | 1 |
| Casado, S; Farré, J; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Sánchez de Miguel, L; Zalba, LR | 1 |
| Chen, JC; Ishimaru, S; Powell, LL; Serna, DL; Wang, D; Wilson, SE; Yomo, T | 1 |
| Hohlfeld, T; Liesener, S; Schanz, A; Schrör, K; Weber, AA | 1 |
| Cranmer, SL; Dopheide, SM; Giuliano, S; Hughan, SC; Jackson, SP; Kulkarni, S; Nesbitt, WS; Rooney, MM; Salem, HH; Yap, CL; Yuan, Y | 1 |
| Andrioli, G; Bellavite, P; Lussignoli, S; Minuz, P; Ortolani, R; Pincelli, S; Solero, P | 1 |
| Cameron, KE; Heptinstall, S; May, JA; Sanderson, HM; Storey, RF; White, AE | 1 |
| Cattaneo, M; Gachet, C; Lecchi, A; Lombardi, R; Zighetti, ML | 1 |
| Duszyk, M; Jurasz, P; Mayers, I; Miranda, C; Radomski, MW; Sawicka, J; Sawicki, G | 1 |
| Dangelmaier, C; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Aizawa, Y; Fuse, I; Higuchi, W; Uesugi, Y | 1 |
| Rodrigues, HL | 1 |
| Atkinson, BT; Pears, CJ; Stafford, MJ; Watson, SP | 1 |
| Durieux, ME; Gear, AR; Hollmann, MW; Hönemann, CW; Kohrs, R; Lo, B; Polanowska-Grabowska, RK | 1 |
| Carroll, RC; Liu, F; Morris, SA; Wang, XF | 1 |
| Jin, J; Kunapuli, SP; Quinton, TM; Rittenhouse, SE; Zhang, J | 1 |
| Cho, MJ; Gartner, TK; Jackson, CW; Lowell, CA; Pestina, TI; Steward, SA | 1 |
| Hinek, A; Pace-Asciak, CR; Reynaud, D | 1 |
| Cho, MJ; Jackson, CW; Kent Gartner, T; Pestina, TI; Steward, SA | 1 |
| Dangelmaier, C; Daniel, JL; Kunapuli, SP; Ozdener, F; Quinton, TM | 1 |
| Casado, S; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Uriarte, AC; Velasco, S; Zalba, LR | 1 |
| Cattaneo, M; Cazenave, JP; Gachet, C; Packham, MA | 1 |
| Atkinson, BT; Jarvis, GE; Snell, DC; Watson, SP | 1 |
| Gratacap, MP; Nieswandt, B; Offermanns, S; Schulte, V; Zywietz, A | 1 |
| Dangelmaier, C; Daniel, JL; Dorsam, RT; Jin, J; Kim, S; Kunapuli, SP; Quinton, TM | 1 |
| Dorsam, RT; Jin, J; Kim, S; Kunapuli, SP | 1 |
| Cho, MJ; Coffman, TM; Gartner, TK; Jackson, CW; Liu, J; Pestina, TI; Steward, SA; Thomas, DW; Wang, D | 1 |
| Bergmeier, W; Brakebusch, C; Fässler, R; Heemskerk, JW; Kuijpers, MJ; Lindhout, T; Nieswandt, B; Offermanns, S; Schulte, V | 1 |
| Ersöz, G; Yakaryilmaz, A; Zergeroğlu, AM | 1 |
| Nieswandt, B; Watson, SP | 1 |
| Bhatt, DL; Jneid, H | 1 |
| Bryckaert, M; Habib, A; Jandrot-Perrus, M; Pawlowski, M; Roger, S; Rosa, JP | 1 |
| Cazenave, JP; Eckly, A; Gachet, C; Lanza, F; Mangin, P; Ohlmann, P | 1 |
| Jin, J; Kim, S; Kunapuli, SP; Murugappan, S; Quinton, TM | 1 |
| Fälker, K; Lange, D; Presek, P | 1 |
| Fauvel-Lafeve, F; Legrand, C; Maurice, P | 1 |
| Best, D; Jarvis, GE; Watson, SP | 1 |
| Berndt, MC; Gartner, TK; Jackson, CW; Liu, J; Pestina, TI; Steward, SA | 1 |
| Hua, J; Iwabuchi, K; Nagaoka, I; Sakamoto, K; Suguro, S; Tsutsumi-Ishii, Y | 1 |
| Macgregor, H; Ragno, G; Valeri, CR | 1 |
| Balduini, C; Bertoni, A; Campus, F; Lova, P; Sinigaglia, F; Torti, M | 1 |
| Forslund, M; Hu, H; Li, N | 1 |
| Farndale, RW; Naseem, KM; Riba, R; Sharifi, M | 1 |
| Hara, A; Hato, T; Iijima, K; Matsumoto, H; Yoshioka, A | 1 |
| Choi, W; Karim, ZA; Whiteheart, SW | 1 |
| Hua, J; Lu-Suguro, JF; Nagaoka, I; Sakamoto, K | 1 |
| Bellm, S; Cornelissen, J; Goddard, M; Kirtland, S; Large, S; Lim, E; Sheridan, K; Vuylsteke, A | 1 |
| Gu, ZL; Liang, ZQ; Qin, ZH; Zhang, HL; Zhu, Y | 1 |
| Kahner, BN; Kim, S; Kunapuli, SP; Lakhani, P; Prabhakar, J; Shankar, H | 1 |
| Begonja, AJ; Gambaryan, S; Geiger, J; Rauchfuss, S; Rukoyatkina, N; Walter, U | 1 |
| Naseem, KM; Oberprieler, NG; Riba, R; Roberts, W | 1 |
| Laposata, M; Salem, RO | 1 |
| Gear, A; Viisoreanu, D | 1 |
| Cendana, C; Farndale, RW; Fung, CY; Mahaut-Smith, MP | 1 |
| Fitzgerald, DJ; Maree, AO | 1 |
| Dawood, BB; Watson, SP; Wilde, J | 1 |
| Du, X; Hay, N; Stojanovic, A; Yin, H | 1 |
| Almeida, L; Costa-Almeida, C; Dinis, A; Figueiredo, A; Garrido, AP; Mota, A; Parada, B; Reis, F; Rocha-Pereira, P; Santos-Dias, J; Santos-Silva, A; Teixeira de Lemos, E; Teixeira, F | 1 |
| Barrabés, JA; Garcia-Dorado, D; Mirabet, M; Quiroga, A | 1 |
| Cazenave, JP; Gachet, C; Hechler, B; Lantz, N; Ravanat, C | 1 |
| Fujishiro, T; Honda, N; Ikeda, M; Ito, K; Ohnishi, K | 1 |
| Filipiak, KJ; Grabowski, M; Huczek, Z; Kochanowski, J; Kochman, J; Opolski, G; Piatkowski, R; Roik, M | 1 |
| Chudzinski-Tavassi, AM; de Lemos, TL; de Sousa, CM; do Nascimento, NR; Ferreira, MA; Pessoa, OD; Schattner, M; Ventura, JS | 1 |
| Akkerman, JW; Cauwenberghs, S; Heemskerk, JW; Heijnen, HF; van Lier, M; Verhoef, S | 1 |
| Chetty, N; Crowther, NJ; Naran, NH | 1 |
| Kim, JM; Yun-Choi, HS | 1 |
| Baldanzi, G; Balduini, C; Bernardi, B; Campus, F; Graziani, A; Guidetti, GF; Lova, P; Torti, M | 1 |
| Farndale, RW; Homer-Vanniasinkam, S; Naseem, KM; Riba, R; Roberts, W | 1 |
| Akkerman, JW; Bezemer, M; Koekman, CA; Korporaal, SJ; van der Wal, DE; Van Eck, M; Verhoef, S | 1 |
| Bergmeier, W; Roden, RC; Stefanini, L | 1 |
| Lozano, ML; Martínez, C; Navarro-Núñez, L; Rivera, J; Vicente, V | 1 |
| Eliautou, S; Gachet, C; Lanza, F; Mangin, PH; Walter, U | 1 |
| Jackson, SP; Jarman, K; Lim, J; Nesbitt, WS; Ono, A; Schoenwaelder, SM | 1 |
| Anantharamaiah, GM; Buga, GM; Chanslor, S; Fogelman, AM; Hough, G; Imaizumi, S; Navab, M; Reddy, ST; Yekta, B | 1 |
| Désiré, L; Eble, JA; Grygielska, B; Leblond, B; Pollitt, AY; Watson, SP | 1 |
| Du, X; Li, Z; Liu, J; Lowell, CA; Ruan, C; Stojanovic, A; Zhang, G | 1 |
| Al-Mondhiry, H; Ballard, JO; McGarvey, V | 1 |
| Bhavaraju, K; Garcia, A; Kim, S; Kunapuli, SP; Schoenwaelder, SM | 1 |
| Armstrong, PC; Chan, MV; Jakubowski, JA; Kirkby, NS; Leadbeater, PD; Mitchell, JA; Warner, TD | 1 |
| Bu, Y; Hwang, DS; Jang, W; Jo, IY; Kang, H; Kim, JI; Lee, BJ; Lee, W; Lew, JH; Maeng, S; Min, K; Park, JW; Yoo, HH | 1 |
| Evans, RJ; Jones, S; Mahaut-Smith, MP | 1 |
| Bhavaraju, K; Dorsam, RT; Hitchcock, IS; Jin, J; Kunapuli, SP; Lakhani, PR; Sanjay, A | 1 |
| Cai, YL; Ruan, JL; Wang, JP; Wu, YX; Xiong, CM; Xu, HX; Ye, YJ | 1 |
| Alberts, AS; Calaminus, SD; Machesky, LM; Thomas, SG; Watson, SP | 1 |
| Battinelli, EM; Italiano, JE; Markens, BA | 1 |
| Chou, DS; Fong, TH; Hsiao, G; Jayakumar, T; Lee, JJ; Lu, WJ; Sheu, JR | 1 |
| Gambaryan, S; Geiger, J; Kehrer, L; Kobsar, A; Krivchenko, A; Mindukshev, I; Nikolaev, VO; Rukoyatkina, N; Schuetz, C; Walter, U; Watson, SP | 1 |
| Alamuddin, N; Crichton, I; FitzGerald, GA; Ibrahim, S; Lawson, JA; Prempeh, M; Puré, E; Rasmussen, LM; Ricciotti, E; Song, WL; Stubbe, J; Wilensky, RL | 1 |
| Bruno, V; Freynhofer, MK; Huber, K; Wojta, J | 1 |
| Diamond, SL; Muthard, RW | 1 |
| Kim, SH; Mo, SJ; Oh, CH; Rhee, YH; Shin, JI; Yun, SJ | 1 |
| Egoshi, M; Miyamoto, A; Shiraishi, M; Tamura, K | 1 |
| Cipolla, L; Guidetti, G; Jin, J; Kim, S; Kunapuli, SP; Okigaki, M; Torti, M | 1 |
| Banerjee, A; Blois, SL; Park, FM; Wood, RD | 1 |
| Boyce, JA; Conley, PB; Cummings, HE; Feng, C; Kanaoka, Y; Laidlaw, TM; Liu, T | 1 |
| Banerjee, D; Bhattacharya, S; Mazumder, S; Sinha, AK | 1 |
| Arman, M; Cox, D; Greinacher, A; Kerrigan, SW; Krauel, K; Tilley, DO; Watson, SP; Weber, C | 1 |
| Basić-Jukić, N; Kes, P; Martinović, Z; Pavlović, DB | 1 |
| Assinger, A; Butler, LM; Hansson, GK; Ketelhuth, DF; Söderberg-Nauclér, C; Wang, Y; Yan, ZQ | 1 |
| Kim, HH; Kim, JL; Kim, YY; Kwon, HK; Kwon, HW; Lee, DH; Lee, JJ; Lim, DH; Nam, GS; Park, HJ; Shin, JH | 1 |
| Banerjee, D; Mazumder, S; Sinha, AK | 1 |
| Harper, MT; Poole, AW; Walsh, TG | 1 |
| Hara, S; Kuwata, H; Murakami, M; Nakatani, Y; Ogawa, M; Rai, K; Suzuki, H; Takakura, Y; Yoda, E | 1 |
| Chen, L; Ding, Z; Hu, L; Ye, J; Zhai, L; Zhang, S; Zhang, Y | 1 |
| Kee, MF; Lam, WA; Myers, DR; Qiu, Y; Sakurai, Y | 1 |
| Badolia, R; Bhavanasi, D; Chen, X; Dangelmaier, CT; Janapati, S; Jin, J; Kim, S; Kunapuli, SP; Manne, BK; Mazharian, A; Senis, YA; Zhang, X | 1 |
| Harper, MT; Hers, I; Poole, AW; van den Bosch, MT | 1 |
| Chen, X; Dai, J; Fan, X; Liu, J; Lu, Y; Wang, C; Wang, K; Wu, X; Zhang, J | 1 |
| Chen, X; Chu, S; Fang, W; Fei, Y; He, G; Li, Y; Wang, D; Wang, S; Wu, Q; Yang, L | 1 |
| Arman, M; Cox, D; Henderson, IR; Kerrigan, SW; Watson, CN; Watson, SP | 1 |
| Chen, M; Cui, Q; Dai, K; He, S; Hu, R; Jiang, M; Li, Z; Ruan, C; Tian, J; Yan, R; Zhang, J; Zhang, Y; Zhao, L | 1 |
| Fu, H; Fu, J; Lu, H; Luo, Y; Ma, S; Wang, W; Xu, H; Zhang, Z; Zhu, X | 1 |
| Berger, JS | 1 |
| Boknäs, N; Faxälv, L; Gibbins, JM; Lindahl, TL; Macwan, AS; Ntzouni, MP; Ramström, S | 1 |
| Li, RHL; Nguyen, N; Tablin, F | 1 |
| Chaudhary, PK; Jee, Y; Kim, S; Lee, SH; Park, KM | 1 |
24 review(s) available for adenosine diphosphate and thromboxane a2
| Article | Year |
|---|---|
Prostaglandins and thromboxanes: "middlemen" modulating platelet function in hemostasis and thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Arteriosclerosis; Blood Coagulation; Blood Platelets; Calcium; Cyclic AMP; Hemostasis; Humans; Prostaglandins; Prostaglandins G; Prostaglandins H; Rats; Thrombosis; Thromboxane A2; Thromboxanes | 1978 |
Hirudin and platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium Chloride; Citrates; Citric Acid; Collagen; Epinephrine; Hirudins; Humans; Platelet Adhesiveness; Platelet Aggregation; Recombinant Fusion Proteins; Serotonin; Thrombin; Thromboxane A2 | 1991 |
Platelet receptors.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Collagen; Humans; Platelet Activation; Platelet Membrane Glycoproteins; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Thrombin; Thromboxane A2 | 1990 |
Aggregin: a platelet ADP receptor that mediates activation.
Topics: Adenosine Diphosphate; Affinity Labels; Collagen; Epinephrine; Humans; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Purinergic; Thrombin; Thromboxane A2 | 1990 |
Role of thromboxane A2.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Epinephrine; Humans; Indomethacin; Kinetics; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1985 |
[Prostaglandins in the cardio-vascular system].
Topics: Adenosine Diphosphate; Cardiovascular Diseases; Cardiovascular Physiological Phenomena; Cardiovascular System; Cyclic AMP; Cytochrome P-450 Enzyme System; Epoprostenol; Humans; Intramolecular Oxidoreductases; Prostaglandins; Thromboxane A2 | 1985 |
Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Diglycerides; Epinephrine; Exocytosis; Glycerides; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Receptors, Cell Surface; Receptors, Purinergic; Thrombin; Thromboxane A2 | 1985 |
Biological actions of prostacyclin and its pharmacological use in platelet studies.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Blood Platelets; Blood Preservation; Calcium; Collagen; Cyclic AMP; Drug Stability; Enzyme Activation; Epoprostenol; Fibrinogen; Humans; Microscopy, Electron; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1985 |
Characterization of thromboxane receptors in human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Binding, Competitive; Blood Platelets; Chemical Phenomena; Chemistry; Cyclic AMP; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Prostaglandins, Synthetic; Radioligand Assay; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Structure-Activity Relationship; Thromboxane A2 | 1985 |
Receptors and receptor mechanisms of endogenous platelet stimulatory and inhibitory mediators.
Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Epinephrine; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin D2; Prostaglandins D; Receptors, Cell Surface; Serotonin; Structure-Activity Relationship; Thrombin; Thromboxane A2; Vasopressins | 1986 |
Platelets and diabetic vascular disease.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; beta-Thromboglobulin; Blood Glucose; Blood Platelets; Blood Vessels; Cell Survival; Diabetes Mellitus; Diabetic Angiopathies; Endothelium; Epoprostenol; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Factor 4; Platelet Function Tests; Thromboxane A2 | 1983 |
Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome.
Topics: Adenosine Diphosphate; Adult; Antigen-Antibody Complex; Arachidonic Acids; Blood Coagulation; Blood Platelets; Blood Vessels; Child; Child, Preschool; Endothelium; Epoprostenol; Hemolytic-Uremic Syndrome; Humans; Kidney; Plasma Exchange; Platelet Adhesiveness; Platelet Aggregation; Purpura, Thrombotic Thrombocytopenic; Thrombin; Thromboxane A2 | 1982 |
[Interactions between the platelets and the vessel wall. Part 1: Physiology (author's transl)].
Topics: Adenosine Diphosphate; Blood Platelets; Blood Vessels; Cell Membrane; Collagen; Endothelium; Epoprostenol; Factor VIII; Glycoproteins; Humans; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Thromboxane A2; von Willebrand Factor | 1980 |
Thromboxane A2, prostacyclin and aspirin: effects on vascular tone and platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Vessels; Cats; Coronary Vessels; Epoprostenol; Guinea Pigs; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits; Thromboxane A2; Thromboxanes | 1980 |
Antiplatelet therapy in coronary heart disease.
Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Aspirin; Blood Platelets; Cerebrovascular Disorders; Coronary Disease; Epinephrine; Epoprostenol; Female; Humans; Male; Middle Aged; Myocardial Infarction; Platelet Adhesiveness; Platelet Aggregation; Propranolol; Thromboxane A2 | 1982 |
Agonist receptors and G proteins as mediators of platelet activation.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Animals; Collagen; Cricetinae; Epinephrine; GTP-Binding Proteins; Humans; Mice; Molecular Sequence Data; Platelet Activation; Receptors, Cell Surface; Receptors, Thrombin; Sequence Alignment; Signal Transduction; Species Specificity; Thrombin; Thromboxane A2 | 1993 |
Properties and regulation of human platelet cation channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Cations; Humans; Inositol 1,4,5-Trisphosphate; Models, Biological; Prostaglandin Endoperoxides, Synthetic; Protein Kinases; Thrombin; Thromboxane A2; Type C Phospholipases; Vasoconstrictor Agents | 1993 |
[Update on the treatment with platelet antiaggregation agents].
Topics: Abciximab; Adenosine Diphosphate; Antibodies, Monoclonal; Arachidonic Acid; Cell Membrane; Eptifibatide; Humans; Immunoglobulin Fab Fragments; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandin-Endoperoxide Synthases; Thromboxane A2; Tirofiban; Tyrosine | 2001 |
Platelet-collagen interaction: is GPVI the central receptor?
Topics: Adenosine Diphosphate; Animals; Cloning, Molecular; Collagen; Hemostasis; Humans; Integrin alpha2beta1; Mice; Mice, Knockout; Models, Biological; Peptide Fragments; Platelet Activation; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Isoforms; Receptors, Collagen; Signal Transduction; Thrombosis; Thromboxane A2 | 2003 |
Advances in antiplatelet therapy.
Topics: Adenosine Diphosphate; Cardiovascular Diseases; Clinical Trials as Topic; Humans; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboxane A2 | 2003 |
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease.
Topics: Adenosine Diphosphate; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Atherosclerosis; Biomarkers; Biotransformation; Blood Coagulation Tests; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Interactions; Drug Resistance; Hemorrhage; Humans; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Thromboxane A2; Thromboxane B2; Ticlopidine; Treatment Failure | 2007 |
The role of platelets in athero-thrombotic events.
Topics: Adenosine Diphosphate; Animals; Atherosclerosis; Blood Platelets; Coronary Artery Disease; Coronary Thrombosis; Fibrinolytic Agents; Hemostasis; Humans; Plaque, Atherosclerotic; Platelet Activation; Platelet Aggregation Inhibitors; Thrombin; Thrombosis; Thromboxane A2 | 2012 |
Importance of platelet aggregation in patients with end-stage renal disease.
Topics: Adenosine Diphosphate; Blood Platelet Disorders; Humans; Kidney Failure, Chronic; Kidney Transplantation; Platelet Aggregation; Renal Dialysis; Renal Replacement Therapy; Risk Factors; Thromboembolism; Thrombosis; Thromboxane A2 | 2013 |
Oral Antiplatelet Therapy for Secondary Prevention of Acute Coronary Syndrome.
Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Administration, Oral; Aging; Blood Platelets; Cyclooxygenase 1; Diabetes Mellitus; Drug Administration Schedule; Hemorrhage; Humans; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Receptors, Purinergic P2Y12; Renal Insufficiency; Risk Factors; Secondary Prevention; Thrombin; Thromboxane A2; Time Factors; Vascular Diseases | 2018 |
9 trial(s) available for adenosine diphosphate and thromboxane a2
| Article | Year |
|---|---|
Preliminary assessment of a novel thromboxane A2 receptor-blocking drug, GR32191, in healthy subjects.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Biphenyl Compounds; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Single-Blind Method; Thromboxane A2 | 1990 |
Effect of aspirin infusions on platelet function in humans.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Collagen; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Time Factors | 1990 |
Effect of vitamin E supplementation on platelet thromboxane A2 production in type I diabetic patients. Double-blind crossover trial.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Clinical Trials as Topic; Collagen; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Humans; Male; Platelet Aggregation; Reference Values; Thromboxane A2; Vitamin E | 1988 |
Antiplatelet effects of oral diltiazem, propranolol, and their combination.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Diltiazem; Drug Interactions; Epinephrine; Humans; Male; Platelet Aggregation Inhibitors; Propranolol; Thromboxane A2 | 1987 |
Inhibition of platelet aggregation and thromboxane synthesis after intake of small amount of icosapentaenoic acid.
Topics: Adenosine Diphosphate; Aged; Arachidonic Acids; Blood Platelets; Chromatography, Gas; Chromatography, High Pressure Liquid; Collagen; Eicosapentaenoic Acid; Epinephrine; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Lipids; Male; Middle Aged; Phosphatidylcholines; Phospholipids; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1984 |
Individual saturated fatty acids and effects on whole blood aggregation in vitro.
Topics: Adenosine Diphosphate; Adult; Anticoagulants; Collagen; Cross-Over Studies; Diet; Dietary Fats; Energy Intake; Fatty Acids; Female; Hirudins; Humans; Lauric Acids; Male; Middle Aged; Myristic Acid; Oleic Acid; Palmitic Acid; Platelet Aggregation; Recombinant Proteins; Thromboxane A2; Thromboxane B2 | 1998 |
Biological efficacy of low against medium dose aspirin regimen after coronary surgery: analysis of platelet function.
Topics: Adenosine Diphosphate; Administration, Oral; Adult; Aged; Aspirin; Blood Platelets; Collagen; Coronary Artery Bypass; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Postoperative Complications; Thromboxane A2; Time Factors | 2006 |
Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Blood Platelets; Cyclooxygenase Inhibitors; Diagnosis, Differential; Female; Hemorrhage; Humans; Indomethacin; Male; Platelet Aggregation; Platelet Function Tests; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Reference Standards; Secretory Vesicles; Thromboxane A2 | 2007 |
Niacin and biosynthesis of PGD₂by platelet COX-1 in mice and humans.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Aortic Aneurysm, Abdominal; Apolipoproteins E; Atherosclerosis; Blood Platelets; Carotid Artery Thrombosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Double-Blind Method; Endothelium, Vascular; Female; Humans; Hypertension; Male; Membrane Proteins; Mice; Mice, Knockout; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, LDL; Receptors, Nicotinic; Receptors, Prostaglandin; Thromboxane A2 | 2012 |
295 other study(ies) available for adenosine diphosphate and thromboxane a2
| Article | Year |
|---|---|
Why do some beta adrenergic agonists inhibit generation of thromboxane A2 in incubates of platelets with arachidonic acid?
Topics: Adenosine Diphosphate; Adrenergic beta-Agonists; Albuterol; Animals; Arachidonic Acids; Blood Platelets; Dogs; In Vitro Techniques; Isoproterenol; Lidocaine; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1978 |
Increased biosynthesis of thromboxane A2 by diabetic platelets.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Blood Platelets; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Pregnancy; Pregnancy in Diabetics; Thromboxane A2; Thromboxanes | 1979 |
Independence of the cyclic AMP-lowering activity of thromboxane A2 from the platelet release reaction.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Cyclic AMP; Egtazic Acid; Epoprostenol; Gallic Acid; Humans; Models, Biological; Platelet Aggregation; Prostaglandins H; Serotonin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1979 |
13-Azaprostanoic acid: a specific antagonist of the human blood platelet thromboxane/endoperoxide receptor.
Topics: Adenosine Diphosphate; Blood Platelets; Fatty Acids; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins H; Prostanoic Acids; Receptors, Drug; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1979 |
Experimental atherosclerosis in rabbits: platelet aggregation, thromboxane A2 generation and anti-aggregatory potency of prostacyclin.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Arteriosclerosis; Epoprostenol; Platelet Aggregation; Prostaglandins; Rabbits; Thromboxane A2; Thromboxanes | 1977 |
The generation of TXA2 in human platelet rich plasma and its inhibition by nictindole and prostacyclin.
Topics: Adenosine Diphosphate; Arachidonic Acids; Blood Platelets; Collagen; Epinephrine; Epoprostenol; Humans; In Vitro Techniques; Indoles; Oxidoreductases; Platelet Aggregation; Prostaglandins; Pyridines; Thrombin; Thromboxane A2; Thromboxane-A Synthase; Thromboxanes | 1979 |
EG-626: not a thromboxane A2 antagonist, but a PGI2 potentiator in platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Collagen; Drug Synergism; Epoprostenol; Phthalazines; Platelet Aggregation; Prostaglandins; Pyridazines; Rabbits; Thromboxane A2; Thromboxanes | 1979 |
The role of platelet-activating factor in platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation Factors; Calcimycin; Calcium; Creatine Kinase; Humans; Lysophosphatidylcholines; Phosphocreatine; Phospholipases; Platelet Aggregation; Rabbits; Thromboxane A2 | 1979 |
Arachidonic acid-induced platelet aggregation independent of ADP-release in a patient with a bleeding disorder due to platelet storage pool disease.
Topics: Adenosine Diphosphate; Aged; Animals; Aorta; Arachidonic Acids; Blood Platelet Disorders; Blood Platelets; Calcimycin; Humans; Male; Muscle Contraction; Platelet Aggregation; Rabbits; Thromboxane A2 | 1979 |
Inhibition of platelet aggregation by a new agent, Ticlopidine.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Blood Platelets; Cell Survival; Collagen; Male; Platelet Aggregation; Prostaglandins G; Pyridines; Rats; Thiophenes; Thrombin; Thromboxane A2 | 1979 |
A dominant role of thromboxane formation in secondary aggregation of platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Blood Platelets; Cats; Chediak-Higashi Syndrome; Indomethacin; Platelet Aggregation; Serotonin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1979 |
[Role of thromboxane A2 in platelet aggregation. Preliminary report].
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Male; Nucleotides, Cyclic; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1979 |
Effects of a polyoxyethylene detergent (Brij 58) on platelet aggregation, release and clotting activity.
Topics: Adenosine Diphosphate; Arachidonic Acids; Blood Platelets; Calcium; Collagen; Detergents; Humans; In Vitro Techniques; Phospholipids; Platelet Aggregation; Polyethylene Glycols; Serotonin; Thrombin; Thromboxane A2 | 1978 |
The role of platelets in the haemostatic mechanism.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Epinephrine; Hemostasis; Humans; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins; Serotonin; Thromboxane A2 | 1978 |
Thromboxane receptor stimulation inhibits adenylate cyclase and reduces cyclic AMP-mediated inhibition of ADP-evoked responses in fura-2-loaded human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Alprostadil; Calcium; Colforsin; Cyclic AMP; Fura-2; Humans; Manganese; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1992 |
Functional implications of cAMP and Ca2+ on prostaglandin I2 and thromboxane A2 synthesis by human endothelial cells.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Caffeine; Calcimycin; Calcium; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Epoprostenol; Humans; Kinetics; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Modification of platelet function by isosorbide dinitrate in patients with coronary artery disease.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Drug Interactions; Endothelium, Vascular; Epoprostenol; Female; Humans; Hypertension; Isosorbide Dinitrate; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Factor 4; Risk Factors; Smoking; Thromboxane A2 | 1992 |
Low concentrations of sodium azide specifically inhibit a thromboxane A2 pathway in human platelets.
Topics: Adenosine Diphosphate; Apyrase; Arachidonic Acid; Aspirin; Azides; Blood Platelets; Calcium; Collagen; Energy Metabolism; Enzyme Activation; Humans; Hydrogen-Ion Concentration; Myosin-Light-Chain Kinase; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Protein Kinase C; Secretory Rate; Serotonin; Sodium Azide; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1992 |
Role of prostaglandin H2-thromboxane A2 in responses of cerebral arterioles during chronic hypertension.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Arterioles; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Imidazoles; Male; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane A2; Vasodilator Agents | 1992 |
Mechanism of inositol 1,4,5-trisphosphate-induced aggregation in saponin-permeabilized platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane Permeability; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Indomethacin; Inositol 1,4,5-Trisphosphate; Platelet Aggregation; Platelet Aggregation Inhibitors; Saponins; Thromboxane A2 | 1992 |
Acute in vitro effects of ethanol on responses of platelets from cholesterol-fed and Watanabe heritable hyperlipidemic rabbits.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol, Dietary; Collagen; Ethanol; Hyperlipidemias; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombin; Thromboxane A2 | 1992 |
Platelet activation by cross-linking HLA class I molecules and Fc receptor.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cross-Linking Reagents; Cytoplasmic Granules; Histocompatibility Antigens Class I; Humans; Hydrogen-Ion Concentration; Immunoglobulin G; Inositol 1,4,5-Trisphosphate; Phosphoproteins; Platelet Activation; Platelet Aggregation; Receptors, Fc; Thromboxane A2 | 1992 |
Regulation of eicosanoid release in human umbilical endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Adenosine Triphosphate; Calcimycin; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Epoprostenol; Humans; Infant, Newborn; Secretory Rate; Stimulation, Chemical; Thrombin; Thromboxane A2; Thromboxane B2; Umbilical Veins | 1991 |
Mechanism of action of a potent antiplatelet peptide, triflavin from Trimeresurus flavoviridis snake venom.
Topics: Adenosine Diphosphate; Calcium; Crotalid Venoms; Fibrinogen; Humans; Iodine Radioisotopes; Peptides; Phosphatidylinositols; Platelet Aggregation Inhibitors; Protein Binding; Thromboxane A2; Thromboxane B2 | 1991 |
Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, adenosine diphosphate release, and recruitment.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; beta-Thromboglobulin; Blood Platelets; Collagen; Erythrocytes; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Membrane Glycoproteins; Serotonin; Thromboxane A2; Thromboxane B2; Thromboxanes | 1991 |
Mode of action of 2-(diethylamino)-7-ethoxychromone on human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Chromones; Colforsin; Collagen; Cyclic AMP; Humans; Iloprost; Phosphoric Diester Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2 | 1991 |
ADP plays an important role in mediating platelet aggregation and cyclic flow variations in vivo in stenosed and endothelium-injured canine coronary arteries.
Topics: Adenosine Diphosphate; Animals; Apyrase; Bridged Bicyclo Compounds, Heterocyclic; Clopidogrel; Coronary Circulation; Coronary Disease; Coronary Vessels; Dogs; Endothelium, Vascular; Fatty Acids, Unsaturated; Female; Hydrazines; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin; Thromboxane A2; Ticlopidine | 1992 |
Rapidity and duration of platelet suppression by enteric-coated aspirin in healthy young men.
Topics: Adenosine Diphosphate; Adult; Aspirin; Blood Platelets; Epinephrine; Epoprostenol; Humans; Male; Platelet Aggregation; Reference Values; Tablets, Enteric-Coated; Thromboxane A2; Time Factors | 1992 |
Adenosine and ATP produce vasoconstriction in the feline pulmonary vascular bed by different mechanisms.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cyclooxygenase Inhibitors; Fatty Acids, Unsaturated; Hydrazines; Lung; Meclofenamic Acid; Phenylisopropyladenosine; Purinergic Antagonists; Receptors, Prostaglandin; Receptors, Purinergic; Receptors, Thromboxane; Thromboxane A2; Vasoconstriction; Vasodilator Agents; Xanthines | 1991 |
Pharmacokinetic and pharmacodynamic profiles of vapiprost, a selective, long-lasting thromboxane receptor antagonist, after single and multiple oral administration to healthy volunteers.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Adult; Biphenyl Compounds; Collagen; Drug Administration Schedule; Heptanoic Acids; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1991 |
[Platelets and cerebral ischemia].
Topics: Adenosine Diphosphate; Blood Platelets; Brain Ischemia; Epoprostenol; Humans; Intracranial Embolism and Thrombosis; Platelet Aggregation; Platelet Function Tests; Serotonin; Thromboxane A2 | 1991 |
Platelet hypersensitivity in cholesterol-fed rabbits: enhancement of thromboxane A2-dependent and thrombin-induced, thromboxane A2-independent platelet responses.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cholesterol; Collagen; Hypercholesterolemia; Male; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Rabbits; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1991 |
Interphenylene 7-oxabicyclo[2.2.1]heptane thromboxane A2 antagonists. Semicarbazone omega-chains.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Fatty Acids, Unsaturated; Humans; Hydrazines; Magnetic Resonance Spectroscopy; Mice; Semicarbazones; Stereoisomerism; Thromboxane A2 | 1991 |
Studies on platelet protein phosphorylation in patients with impaired responses to platelet agonists.
Topics: Adenosine Diphosphate; Blood Platelet Disorders; Blood Platelets; Blood Proteins; Collagen; Edetic Acid; Epinephrine; Erythrocyte Aggregation; Humans; Myosins; Phosphoproteins; Phosphorylation; Platelet Storage Pool Deficiency; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1990 |
Levamisole inhibits in vivo rat platelet aggregation by a release of prostacyclin-like factor.
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Epoprostenol; Half-Life; In Vitro Techniques; Leukocytes; Levamisole; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Thromboxane A2 | 1990 |
The correlation between Ca2+ influx and inositol 1, 4, 5-trisphosphate (IP3) formation in platelets stimulated by various agonists.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Humans; Inositol 1,4,5-Trisphosphate; Ionomycin; Platelet Activating Factor; Temperature; Thrombin; Thromboxane A2 | 1990 |
Inhibitory effects of endothelial cells and calcium channel blockers on platelet aggregation.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Bone Marrow Cells; Calcium Channel Blockers; Collagen; Diltiazem; Endothelium, Vascular; Epoprostenol; Fibroblasts; Humans; Nicardipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Verapamil | 1990 |
Effects of various inhibitors on platelet activation induced by TP 82, a CD 9 monoclonal antibody.
Topics: Adenosine Diphosphate; Aequorin; Amino Acid Sequence; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Arachidonic Acid; Arachidonic Acids; Aspirin; Calcium; Dose-Response Relationship, Drug; Humans; Membrane Glycoproteins; Molecular Sequence Data; Oligopeptides; Platelet Activation; Serotonin; Tetraspanin 29; Thromboxane A2 | 1990 |
Proaggregatory effect of epinephrine on rabbit platelets inhibited by ticlopidine.
Topics: Adenosine Diphosphate; Amiloride; Animals; Aspirin; Drug Interactions; Epinephrine; Hydrogen-Ion Concentration; Male; Methylamines; Monensin; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Receptors, Adrenergic, alpha; Sodium; Thromboxane A2; Ticlopidine | 1990 |
Inhibition of rabbit platelet aggregation by 1,4-naphthoquinones.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Collagen; Naphthoquinones; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Thrombin; Thromboxane A2 | 1990 |
Low molecular weight heparin as an anticoagulant for in vitro platelet function studies.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Collagen; Dose-Response Relationship, Drug; Epinephrine; Epoprostenol; Heparin, Low-Molecular-Weight; Humans; Male; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Function Tests; Ristocetin; Thrombin; Thromboxane A2 | 1990 |
Inositol phospholipid metabolism in human platelets stimulated by ADP.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Fibrinogen; Humans; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Platelet Aggregation; Thromboxane A2; Type C Phospholipases | 1990 |
Endothelium-dependent contraction induced by platelet-derived substances in canine basilar arteries.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Basilar Artery; Blood Platelets; Cyproheptadine; Dogs; Endothelium, Vascular; Female; Male; Serotonin; Thrombin; Thromboxane A2; Vasoconstriction | 1990 |
[The maintenance of placental circulation--the study on the platelet inhibition activity of placental chorioepithelial brush border membrane].
Topics: Adenosine Diphosphate; Apyrase; Arachidonic Acids; Female; Humans; Microvilli; Placenta; Platelet Aggregation Inhibitors; Pregnancy; Ristocetin; Thromboxane A2; Trophoblasts | 1990 |
Stimulus-response coupling in human platelets activated by monoclonal antibodies to the CD9 antigen, a 24 kDa surface-membrane glycoprotein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Antibodies, Monoclonal; Antigens, CD; Antigens, Differentiation; Aspirin; Blood Platelets; Calcium; Collagen; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fab Fragments; Isoquinolines; Membrane Glycoproteins; Phosphoproteins; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Serotonin; Signal Transduction; Tetraspanin 29; Thromboxane A2 | 1990 |
Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb.IIIa complex inhibits receptor function.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Binding Sites; Blood Platelets; Crotalid Venoms; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Kinetics; Molecular Sequence Data; Oligopeptides; Peptides; Phospholipases; Phospholipases A; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Binding; Serotonin; Thromboxane A2; Viper Venoms | 1990 |
Reversal of thromboxane A2/prostaglandin H2 and ADP-induced calcium release in intact platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Chlortetracycline; Cyclic AMP; Epoprostenol; Humans; Ion Channels; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Prostanoic Acids; Stimulation, Chemical; Thromboxane A2; Thromboxanes | 1985 |
Receptor-operated channels in human platelets.
Topics: Adenosine Diphosphate; Barium; Biological Transport; Blood Platelets; Cadmium; Calcium; Cesium; Electrophoresis, Gel, Two-Dimensional; Humans; Ion Channels; Lithium; Membrane Potentials; Nickel; Platelet Activating Factor; Sodium; Spectrometry, Fluorescence; Thrombin; Thromboxane A2 | 1989 |
Iron chelators inhibit human platelet aggregation, thromboxane A2 synthesis and lipoxygenase activity.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Deferiprone; Deferoxamine; Epinephrine; Humans; Iron; Iron Chelating Agents; Lipoxygenase; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Pyridones; Thromboxane A2 | 1989 |
Influence of strontium chloride on blood platelet function.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Collagen; In Vitro Techniques; Nephelometry and Turbidimetry; Platelet Aggregation; Rabbits; Strontium; Thromboxane A2; Thromboxane B2; Thromboxanes | 1989 |
Increased platelet aggregation and intracellular calcium in hypertensive patients: effects of cyclo-oxygenase blockade.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Platelet Aggregation; Thromboxane A2 | 1989 |
Vasospasm and injuries of cerebral arteries induced by activation of platelets in vivo: it may be due to thromboxane A2.
Topics: Adenosine Diphosphate; Animals; Cerebral Arteries; Ischemic Attack, Transient; Male; Platelet Aggregation; Rabbits; Reference Values; Thromboxane A2 | 1989 |
Thromboxane A2 activates phospholipase C in astrocytoma cells via pertussis toxin-insensitive G-protein.
Topics: Adenosine Diphosphate; Astrocytoma; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Enzyme Activation; Fatty Acids, Unsaturated; GTP-Binding Proteins; Hydrazines; Inositol Phosphates; Pertussis Toxin; Phosphatidylinositols; Receptors, Prostaglandin; Receptors, Thromboxane; Ribose; Thromboxane A2; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
Evidence for two mechanisms of thrombin-induced platelet activation: one proteolytic, one receptor mediated.
Topics: Adenosine Diphosphate; Humans; In Vitro Techniques; Leupeptins; Phosphatidylinositols; Platelet Activating Factor; Platelet Activation; Receptors, Cell Surface; Receptors, Thrombin; Serotonin; Thrombin; Thromboxane A2; Trypsin | 1989 |
Characterization of the normal bovine platelet aggregation response.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Cattle; Epinephrine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioimmunoassay; Serotonin; Thrombin; Thromboxane A2; Thromboxane B2 | 1989 |
Mathematical analysis of mural thrombogenesis. Concentration profiles of platelet-activating agents and effects of viscous shear flow.
Topics: Adenosine Diphosphate; Antithrombin III; Blood Platelets; Collagen; Computer Simulation; Heparin; Humans; Kinetics; Mathematics; Microscopy, Fluorescence; Models, Biological; Platelet Activation; Regional Blood Flow; Thrombin; Thrombosis; Thromboxane A2; Video Recording; Viscosity; von Willebrand Factor | 1989 |
[Effect of a new thromboxane A2 antagonist, S-145, on platelet aggregation].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Adult; Animals; Arachidonic Acids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Collagen; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thromboxane A2 | 1989 |
Prothrombotic cytotoxicity of cyanoacrylate tissue adhesive.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Bucrylate; Cells, Cultured; Cyanoacrylates; Endothelium, Vascular; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Platelet Aggregation; Rats; Thromboxane A2; Tissue Adhesives | 1989 |
The role of platelet prostanoids and dense granule compounds in initial attachment, spreading and aggregation of platelets on collagen substrates.
Topics: Adenosine Diphosphate; Blood Platelets; Collagen; Cytoplasmic Granules; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Antagonists; Prostaglandin Endoperoxides; Prostaglandins H; Serotonin; Thromboxane A2 | 1989 |
Effect of dietary fish on plasma selenium and its relation to haemostatic changes in healthy adults.
Topics: Adenosine Diphosphate; Adult; Animals; Diet; Eicosapentaenoic Acid; Fishes; Homeostasis; Humans; Male; Phosphatidylcholines; Platelet Aggregation; Selenium; Sweden; Thromboxane A2 | 1987 |
Antithrombotic effects of the thromboxane A2 antagonist, SQ 28,668, in vitro and in the coronary circulation in vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Coronary Circulation; Cyclic AMP; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Species Specificity; Swine; Thromboxane A2; Thromboxane-A Synthase | 1988 |
Effect of early and advanced atherosclerosis on vascular responses to serotonin, thromboxane A2, and ADP.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Blood Vessels; Diet, Atherogenic; Macaca fascicularis; Male; Serotonin; Thromboxane A2; Vasoconstriction | 1989 |
Vasospasm and injuries of cerebral arteries induced by activation of platelets in vivo: it may be due to thromboxane A2.
Topics: Adenosine Diphosphate; Animals; Arteries; Cerebrovascular Circulation; Ischemic Attack, Transient; Male; Platelet Aggregation; Rabbits; Thromboxane A2 | 1985 |
Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists.
Topics: Adenosine Diphosphate; Animals; Dogs; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1986 |
Ex vivo platelet studies following oral nisoldipine in normotensive insulin-dependent diabetics and non-diabetic controls.
Topics: Adenosine Diphosphate; beta-Thromboglobulin; Blood Platelets; Catecholamines; Collagen; Diabetes Mellitus, Type 1; Epinephrine; Humans; In Vitro Techniques; Nifedipine; Nisoldipine; Physical Exertion; Platelet Aggregation; Platelet Factor 4; Reference Values; Thromboxane A2 | 1988 |
Activation of human platelets by N-substituted aminophospholipids.
Topics: 4-Chloro-7-nitrobenzofurazan; Adenosine Diphosphate; Blood Platelets; Cyclic AMP; Epoprostenol; Humans; Indomethacin; Phosphatidylserines; Platelet Aggregation; Serotonin; Theophylline; Thromboxane A2 | 1985 |
Zinc-induced platelet aggregation is mediated by the fibrinogen receptor and is not accompanied by release or by thromboxane synthesis.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelet Disorders; Blood Platelets; Calcium; Collagen; Copper; Epoprostenol; Glycoproteins; Heparin; Humans; Manganese; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Serotonin; Thromboxane A2; Thromboxanes; Zinc | 1985 |
Binding of an 125I-labeled thromboxane A2/prostaglandin H2 receptor antagonist to washed canine platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Dogs; Epinephrine; Hydrogen-Ion Concentration; Kinetics; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Structure-Activity Relationship; Thromboxane A2; Thromboxanes | 1985 |
Aza-substituted omega-side-chain modifications of 7-oxabicyclo[2.2.1]heptane thromboxane A2 receptor antagonists: structure-activity relationships.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Bridged Bicyclo Compounds; Humans; Indicators and Reagents; Platelet Aggregation; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Structure-Activity Relationship; Thromboxane A2 | 1985 |
Disparate effects of the calcium-channel blockers, nifedipine and verapamil, on alpha 2-adrenergic receptors and thromboxane A2-induced aggregation of human platelets.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chromatography, Gel; Collagen; Cyclic AMP; Drug Synergism; Epinephrine; Humans; Nifedipine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Adrenergic, alpha; Thromboxane A2; Tritium; Verapamil; Yohimbine | 1986 |
Influence of granulocyte elastase-like proteinase (ELP) on platelet functions.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Epinephrine; Granulocytes; Humans; Pancreatic Elastase; Platelet Aggregation; Ristocetin; Serotonin; Thrombin; Thromboxane A2 | 1986 |
The roles of prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation in man and the rat.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Creatine Kinase; Dose-Response Relationship, Drug; Humans; Imidazoles; In Vitro Techniques; Male; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides; Rats; Rats, Inbred Strains; Species Specificity; Thromboxane A2; Thromboxane B2 | 1986 |
The in vitro effect of amrinone on platelet aggregation in human whole blood.
Topics: Adenosine Diphosphate; Aminopyridines; Amrinone; Arachidonic Acid; Arachidonic Acids; Collagen; Humans; In Vitro Techniques; Male; Platelet Aggregation; Thromboxane A2 | 1986 |
Inhibition of whole blood platelet aggregation by nicardipine, and synergism with prostacyclin in-vitro.
Topics: Adenosine Diphosphate; Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Collagen; Drug Synergism; Epoprostenol; Female; Humans; Kinetics; Male; Nicardipine; Nifedipine; Platelet Aggregation; Reference Values; Thromboxane A2; Thromboxane B2 | 1986 |
Effects of dietary supplementation with cod-liver oil on endothelium-dependent responses in porcine coronary arteries.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Cod Liver Oil; Coronary Vessels; Diet; Dinoprost; Endothelium, Vascular; Fish Oils; In Vitro Techniques; Indomethacin; Muscle Relaxation; Platelet Aggregation; Prostaglandins F; Serotonin; Swine; Thromboxane A2 | 1987 |
Effects of latamoxef on in vitro and ex vivo thromboxane A2 generation in human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cell Membrane; Humans; Moxalactam; Platelet Aggregation; Thromboxane A2 | 1988 |
Exchange of cyclooxygenase dependent metabolites between vessel wall and platelets in arterial thrombosis.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Epoprostenol; Imidazoles; Male; Mesenteric Arteries; Platelet Aggregation; Propionates; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thrombosis; Thromboxane A2; Tranylcypromine | 1988 |
Studies on the effect of long-term use of low dose aspirin in Kawasaki disease.
Topics: Adenosine Diphosphate; Aspirin; Child, Preschool; Collagen; Dose-Response Relationship, Drug; Epinephrine; Epoprostenol; Female; Humans; Male; Mucocutaneous Lymph Node Syndrome; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Prostaglandins F; Thromboxane A2; Thromboxane B2; Time Factors | 1988 |
Interrelation of platelet aggregation, release reaction and thromboxane A2 production.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Antibodies, Monoclonal; Blood Platelets; Collagen; Epinephrine; Humans; Oligopeptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Thromboxane A2; Thromboxane B2 | 1988 |
Adrenaline-induced hyperaggregability of platelets and enhanced thromboxane release in anorexia nervosa.
Topics: Adenosine Diphosphate; Anorexia Nervosa; Body Weight; Collagen; Epinephrine; Humans; Platelet Aggregation; Platelet Count; Thromboxane A2 | 1986 |
Mechanisms responsible for coronary vasospasm.
Topics: Adenosine Diphosphate; Animals; Coronary Vasospasm; Dinoprost; Dogs; Endothelium; Epoprostenol; Heart; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandins F; Receptors, Adrenergic; Serotonin; Swine; Swine, Miniature; Sympathetic Nervous System; Thromboxane A2 | 1986 |
Relative insensitivity of epinephrine induced platelet aggregation to prostacyclin.
Topics: Adenosine Diphosphate; Collagen; Epinephrine; Epoprostenol; Humans; Platelet Aggregation; Thromboxane A2 | 1986 |
[Increased adhesive and aggregation activity of the platelets of ischemic heart disease patients with stable stenocardia].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angina Pectoris; Coronary Disease; Humans; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1987 |
Inhibition of platelet 5-HT secretion and of 5-HT induced vasoconstriction by paracetamol.
Topics: Acetaminophen; Adenosine Diphosphate; Aspirin; Blood Platelets; Humans; In Vitro Techniques; Platelet Aggregation; Salicylates; Salicylic Acid; Serotonin; Thromboxane A2; Vasoconstriction | 1987 |
Platelet active concentration profiles near growing thrombi. A mathematical consideration.
Topics: Adenosine Diphosphate; Blood Platelets; Humans; Mathematics; Models, Biological; Platelet Aggregation; Thrombin; Thrombosis; Thromboxane A2 | 1986 |
Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Epinephrine; Humans; Male; Platelet Aggregation; Thromboxane A2 | 1986 |
[Mechanisms of thrombocyte aggregation in experimental hypoparathyroidism].
Topics: Adenosine Diphosphate; Animals; Collagen; Hypoparathyroidism; Imidazoles; Indomethacin; Platelet Aggregation; Rabbits; Thromboxane A2 | 1986 |
Thromboxane A2/prostaglandin H2 mobilizes calcium in human blood platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Chlortetracycline; Epoprostenol; Humans; Indomethacin; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Prostanoic Acids; Stimulation, Chemical; Thromboxane A2; Thromboxanes | 1985 |
Platelet function during continuous insulin infusion treatment in insulin-dependent diabetic patients.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acid; Arachidonic Acids; Blood Glucose; Blood Platelets; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Female; Humans; Insulin; Insulin Infusion Systems; Lipoproteins; Male; Middle Aged; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1985 |
Platelet aggregation in whole blood: the role of thromboxane A2 and adenosine diphosphate.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; Cyclooxygenase Inhibitors; Epinephrine; Flurbiprofen; Humans; Imidazoles; In Vitro Techniques; Lipoxygenase Inhibitors; Platelet Aggregation; Pyrazoles; Thrombin; Thromboxane A2; Thromboxane-A Synthase | 1985 |
[Arachidonic acid metabolism in platelets].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acids; Blood Platelets; Collagen; Humans; Indomethacin; Platelet Aggregation; Rabbits; Thromboxane A2 | 1985 |
Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Cyclic AMP; Epoprostenol; Female; Humans; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Thromboxane A2; Thromboxane B2 | 1984 |
Congenital deficiency of thromboxane and prostacyclin.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Aspirin; Blood Coagulation Tests; Blood Platelet Disorders; Cells, Cultured; Chromatography, Thin Layer; Epoprostenol; Hemorrhage; Humans; Male; Oxygenases; Plasma; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxanes | 1980 |
Platelet - vessel wall interaction: role of blood clotting.
Topics: Adenosine Diphosphate; Animals; Aorta; Blood Coagulation; Blood Platelets; Cod Liver Oil; Collagen; Endothelium; Epoprostenol; Factor VII; In Vitro Techniques; Rats; Thrombin; Thromboplastin; Thrombosis; Thromboxane A2 | 1981 |
Thromboxane A2 in skin-bleeding-time blood and in clotted venous blood before and after administration of acetylsalicylic acid.
Topics: Adenosine Diphosphate; Adult; Aspirin; Bleeding Time; England; Hemorrhage; Hemostasis; Humans; Male; Platelet Aggregation; Platelet Function Tests; Skin; Sweden; Thromboxane A2; Thromboxane B2; Thromboxanes | 1983 |
Synergized activation of human platelets by epinephrine and platelet-activating factor-acether is adenosine diphosphate and thromboxane A2-independent.
Topics: Adenosine Diphosphate; Drug Synergism; Epinephrine; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Thromboxane A2; Thromboxanes | 1983 |
[Prevention of thrombosis by thrombocyte inhibitors. 1. Cell regulation mechanisms and pharmacological modification].
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Cyclic AMP; Dextrans; Dipyridamole; Humans; Hydroxychloroquine; Indomethacin; Platelet Aggregation; Prostaglandins; Sulfinpyrazone; Thrombosis; Thromboxane A2 | 1980 |
Biochemical and pharmacological evaluation of thromboxane synthetase inhibitors.
Topics: Adenosine Diphosphate; Arachidonic Acids; Blood Platelets; Cyclooxygenase Inhibitors; Epinephrine; Humans; Oxidoreductases; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins H; Receptors, Cell Surface; Receptors, Prostaglandin; Thromboxane A2; Thromboxane B2; Thromboxane-A Synthase | 1980 |
Prostaglandin F2 alpha antagonizes thromboxane A2-induced human platelet aggregation.
Topics: Adenosine Diphosphate; Blood Platelets; Cell Membrane; Cyclic AMP; Dinoprost; Dinoprostone; Drug Antagonism; Epoprostenol; Humans; Kinetics; Platelet Aggregation; Prostaglandins E; Prostaglandins F; Receptors, Prostaglandin; Thromboxane A2; Thromboxanes | 1982 |
Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2 receptor interaction.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Drug Interactions; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Prostanoic Acids; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Thromboxanes | 1984 |
The stimulatory effect of prostacyclin (PGI2) on isolated rabbit and rat aorta is probably associated to the generation of a thromboxane A2 (TXA2) "like-material".
Topics: Adenosine Diphosphate; Animals; Aorta, Thoracic; Aspirin; Corticosterone; Epoprostenol; Imidazoles; In Vitro Techniques; Indomethacin; Male; Prostaglandins; Rabbits; Rats; Species Specificity; Thromboxane A2; Thromboxanes; Vasoconstriction | 1983 |
Antithrombogenic effects of calcium channel blockers: synergism with prostacyclin and thromboxane synthase inhibitors.
Topics: Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium Channel Blockers; Diltiazem; Drug Synergism; Epoprostenol; Humans; Nicotinic Acids; Nifedipine; Nimodipine; Oxidoreductases; Platelet Aggregation; Thrombin; Thromboxane A2; Thromboxane-A Synthase; Verapamil | 1984 |
Inhibition of platelet aggregation by a new agent, 2,2'-dithiobis-(N-2-hydroxypropyl benzamide) (KF4939).
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Benzamides; Collagen; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Mice; Papaverine; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thrombin; Thrombocytopenia; Thrombosis; Thromboxane A2 | 1983 |
The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Factor VIII; Humans; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Inhibitory effects of diltiazem on platelet activation caused by ionophore A23187 plus ADP or epinephrine in subthreshold concentrations.
Topics: Adenosine Diphosphate; Adult; Benzazepines; Calcimycin; Calcium Chloride; Diltiazem; Epinephrine; Epoprostenol; Humans; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1983 |
Effect of ethanol on vascular prostacyclin (prostaglandin I2) synthesis, platelet aggregation, and platelet thromboxane release.
Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acids; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Endothelium; Epinephrine; Epoprostenol; Ethanol; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation; Rats; Thromboxane A2; Thromboxanes; Umbilical Veins | 1983 |
Inhibition of prostanoid-mediated platelet aggregation in vivo and in vitro by 3-hydroxymethyl-dibenzo(b,f)thiepin 5,5-dioxide (L-640,035).
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Collagen; Dibenzothiepins; Electric Stimulation; Female; Guinea Pigs; Humans; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombosis; Thromboxane A2; Thromboxane B2; Thromboxanes | 1984 |
A major role of ADP in thromboxane transfer experiments: studies in patients with platelet secretion defects.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Cytoplasmic Granules; Humans; In Vitro Techniques; Platelet Aggregation; Serotonin; Thromboxane A2; Thromboxanes | 1984 |
Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro.
Topics: Adenosine Diphosphate; Apyrase; beta-Thromboglobulin; Blood Platelets; Calcium; Creatine Kinase; Drug Synergism; Humans; Lysophosphatidylcholines; Phosphocreatine; Platelet Activating Factor; Platelet Aggregation; Platelet Factor 4; Serotonin; Thromboxane A2 | 1981 |
In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man.
Topics: Adenosine Diphosphate; Centrifugation; Cimetidine; Cold Temperature; Humans; In Vitro Techniques; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Thromboxanes | 1984 |
Inhibition of thromboxane A2 synthesis in human platelets by coagulation factor Xa.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Dinoprostone; Factor X; Factor Xa; Humans; Platelet Aggregation; Prostaglandins E; Radioimmunoassay; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Inhibition of ADP-induced platelet aggregation by reduced factor Xa.
Topics: Adenosine Diphosphate; Alprostadil; Chemical Phenomena; Chemistry; Dithiothreitol; Factor X; Factor Xa; Humans; Oxidation-Reduction; Platelet Aggregation; Prostaglandins E; Prostaglandins E, Synthetic; Sepharose; Solubility; Thromboxane A2 | 1983 |
Abnormalities of aggregation, thromboxane A2 synthesis, and 14C serotonin release in platelets of patients with idiopathic scoliosis.
Topics: Adenosine Diphosphate; Adolescent; Adult; Arachidonic Acids; Blood Platelets; Child; Collagen; Epinephrine; Female; Humans; Platelet Aggregation; Scoliosis; Serotonin; Thromboxane A2; Thromboxanes | 1983 |
TXA2-antagonistic properties of agents affecting prostaglandin synthesis or the cyclic nucleotide system in human platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Humans; In Vitro Techniques; Nucleotides, Cyclic; Platelet Aggregation; Prostaglandins; Thromboxane A2; Thromboxanes | 1983 |
Influence of propranolol and 4-hydroxypropranolol on platelet aggregation and thromboxane A2 generation.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acids; Cell Membrane; Dose-Response Relationship, Drug; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Propranolol; Thromboxane A2; Thromboxanes | 1983 |
"In vitro" activity of urokinase on platelet function and on ADP degradation by vascular tissue.
Topics: Adenosine Diphosphate; Animals; Aorta; Dose-Response Relationship, Drug; Endopeptidases; Endothelium; Epoprostenol; Humans; Muscle, Smooth, Vascular; Platelet Aggregation; Rabbits; Rats; Rats, Inbred Strains; Thromboxane A2; Urokinase-Type Plasminogen Activator | 1982 |
Pathophysiological aspects of platelet aggregation in relation to blood flow rheology in microcirculation.
Topics: Adenosine Diphosphate; Blood Physiological Phenomena; Blood Platelets; Blood Viscosity; Epoprostenol; Erythrocytes; Humans; Ischemia; Microcirculation; Platelet Aggregation; Rheology; Thromboxane A2 | 1981 |
One, two, three or more pathways for platelet aggregation.
Topics: Acetophenones; Adenosine Diphosphate; Arachidonic Acids; Aspirin; Blood Platelets; Cyclooxygenase Inhibitors; Humans; Lysophosphatidylcholines; Platelet Activating Factor; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Thrombin; Thromboxane A2 | 1980 |
Testosterone potentiation of ionophore and ADP induced platelet aggregation: relationship to arachidonic acid metabolism.
Topics: Adenosine Diphosphate; Animals; Anti-Bacterial Agents; Arachidonic Acids; Aspirin; Blood Platelets; Calcimycin; Humans; Indomethacin; Platelet Aggregation; Rabbits; Serum Albumin; Testosterone; Thromboxane A2 | 1981 |
Modulation of Platelet thromboxane A2 and arterial prostacyclin by dietary vitamin E.
Topics: Adenosine Diphosphate; Animals; Aorta; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Epoprostenol; Male; Prostaglandins; Rats; Rats, Inbred Strains; Thromboxane A2; Thromboxanes; Vitamin E; Vitamin E Deficiency | 1981 |
Thromboxane A2 and the endoperoxides mediate canine platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Dogs; Dose-Response Relationship, Drug; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins E; Prostaglandins F; Thromboxane A2; Thromboxane B2; Thromboxanes | 1981 |
Prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation of rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Collagen; Creatine Kinase; In Vitro Techniques; Indomethacin; Male; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin-Endoperoxide Synthases; Rabbits; Thromboxane A2; Thromboxanes; Time Factors | 1982 |
Increased platelet activity after termination of prostacyclin infusion into man.
Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Arachidonic Acids; Arteriosclerosis Obliterans; Blood Platelets; Collagen; Epoprostenol; Female; Humans; Middle Aged; Platelet Aggregation; Prostaglandins; Thromboangiitis Obliterans; Thromboxane A2 | 1981 |
Enhancement of arterial thromboformation by uric acid, a free radical scavenger.
Topics: Adenosine Diphosphate; Animals; Arterial Occlusive Diseases; Epoprostenol; Free Radicals; Photometry; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Strains; Thrombosis; Thromboxane A2; Tranylcypromine; Uric Acid | 1982 |
The interactions of lipids, platelets and endothelial cells in thrombogenesis.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Blood Vessels; Coronary Disease; Diet; Disease Models, Animal; Endothelium; Fatty Acids; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Thrombosis; Thromboxane A2 | 1980 |
Activation of guinea-pig platelets induced by convulxin, a substance extracted from the venom of Crotalus durissus cascavella.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Crotalid Venoms; Epoprostenol; Guinea Pigs; In Vitro Techniques; Indomethacin; Lectins, C-Type; Platelet Aggregation; Thromboxane A2; Thromboxane B2 | 1980 |
Thromboxane A2/prostaglandin H2 directly stimulates platelet shape change independent of secreted ADP.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Humans; In Vitro Techniques; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Thromboxane A2; Thromboxanes | 1982 |
Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein.
Topics: Adenosine Diphosphate; Arachidonic Acids; Blood Platelets; C-Reactive Protein; Humans; Indomethacin; Platelet Aggregation; Serotonin; Stimulation, Chemical; Thromboxane A2; Thromboxane B2; Thromboxanes | 1982 |
Stereo-dependent inhibition of human platelet function by the optical isomers of trimetoquinol.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Humans; In Vitro Techniques; Isoquinolines; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Stereoisomerism; Thromboxane A2; Tretoquinol | 1981 |
Effects of heparin on platelet aggregation and release and thromboxane A2 production.
Topics: Adenosine Diphosphate; Adult; Animals; Arachidonic Acids; Blood Platelets; Carbon Radioisotopes; Citrates; Collagen; Epinephrine; Heparin; Humans; Platelet Aggregation; Rabbits; Radioimmunoassay; Serotonin; Thromboxane A2; Thromboxanes; Time Factors | 1981 |
Mediators of immune-complex-induced aggregation of polymorphonuclear neutrophils. II. Platelet-activating factor as the effector substance of immune-induced aggregation.
Topics: Adenosine Diphosphate; Animals; Antigen-Antibody Complex; Arachidonic Acids; Blood Platelets; Blood Proteins; Cell Aggregation; Complement C5; Cytochalasin B; Humans; Neutropenia; Neutrophils; Phagocytosis; Rabbits; Thromboxane A2 | 1981 |
Streptokinase and rt-PA activate platelets by a different way: implications on the rethrombosis rate after their administration in myocardial infarction.
Topics: Adenosine Diphosphate; beta-Thromboglobulin; Blood Platelets; Cell Adhesion Molecules; Fibrinogen; Flow Cytometry; Humans; Myocardial Infarction; P-Selectin; Plasminogen Activator Inhibitor 1; Plasminogen Activators; Platelet Activation; Platelet Membrane Glycoproteins; Recombinant Proteins; Recurrence; Serotonin; Streptokinase; Thrombin; Thrombolytic Therapy; Thromboxane A2 | 1995 |
Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Hirudins; Humans; Iloprost; Magnesium Chloride; Molecular Sequence Data; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Streptokinase; Thromboxane A2 | 1995 |
The effect of inhaled anesthetics on the platelet aggregation and the ligand-binding affinity of the platelet thromboxane A2 receptor.
Topics: Adenosine Diphosphate; Anesthetics, Inhalation; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Enflurane; Epinephrine; Fatty Acids, Monounsaturated; Halothane; Humans; Isoflurane; Ligands; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Tritium | 1995 |
Extracellular ATP inhibits agonist-induced mobilization of internal calcium in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Collagen; Creatine Kinase; Humans; Kinetics; Nucleotides; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic P2; Thrombin; Thromboxane A2 | 1995 |
Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aging; Epinephrine; Female; Flow Cytometry; Humans; Infant, Newborn; Male; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2 | 1994 |
Antiplatelet actions of 2-(4-[1-(2-chlorophenyl) piperazinyl]) methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one compound.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cyclic AMP; Epinephrine; Fibrinogen; Humans; Imidazoles; Pancreatic Elastase; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinazolines; Rabbits; Receptors, Cell Surface; Signal Transduction; Thromboxane A2; Thromboxane B2 | 1995 |
The kinetics of chondroitin 4-sulfate release from stimulated platelets and its relation to thromboxane A2 formation and granule secretion.
Topics: Adenosine Diphosphate; Blood Platelets; Chondroitin Sulfates; Collagen; Cytoplasmic Granules; Humans; Platelet Aggregation; Thrombin; Thromboxane A2; Time Factors | 1994 |
Fibrinogen binding is independent of an increase in intracellular calcium concentration in thrombin degranulated platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Cell Degranulation; Evaluation Studies as Topic; Fibrinogen; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Binding; Receptors, Thromboxane; Thromboxane A2; Thromboxanes | 1995 |
Estrogen pretreatment directly potentiates endothelium-dependent vasorelaxation of porcine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arginine; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Nitroglycerin; Orchiectomy; Prostaglandin Endoperoxides, Synthetic; Reference Values; Sex Characteristics; Swine; Tamoxifen; Thromboxane A2; Vasoconstrictor Agents; Vasodilation | 1995 |
The effects of aspirin and paracetamol on the aggregation of equine blood platelets.
Topics: Acetaminophen; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Platelets; Cell Size; Collagen; Dose-Response Relationship, Drug; Horses; In Vitro Techniques; Nephelometry and Turbidimetry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1994 |
Different effects of endothelin-3 on the Ca2+ discharge induced by agonists and Ca(2+)-ATPase inhibitors in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Antioxidants; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Agonists; Calcium-Transporting ATPases; Endothelins; Fatty Acids, Unsaturated; Fura-2; Humans; Hydrazines; Hydroquinones; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Endothelin; Receptors, Thromboxane; Terpenes; Thapsigargin; Thrombin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Alginates; Animals; Arginine; Calcimycin; Coronary Circulation; Coronary Vessels; Drug Carriers; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Glucuronic Acid; Heart; Hexuronic Acids; Indomethacin; Ketanserin; Male; Microcirculation; Muscle Relaxation; Myocardial Infarction; Myocardium; Nitroarginine; Nitroprusside; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Sepharose; Serotonin; Swine; Thromboxane A2; Vasodilation | 1994 |
Enhancement of thrombotic arterial occlusion following cholesterol feeding in the guinea-pig: a role for thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arterial Occlusive Diseases; Cholesterol, Dietary; Collagen; Femoral Artery; Guinea Pigs; Male; Photochemistry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombosis; Thromboxane A2; Time Factors | 1994 |
Effect of picotamide on the calcium mobilization and phospholipase C activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Enzyme Activation; Humans; In Vitro Techniques; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thrombin; Thromboxane A2; Type C Phospholipases | 1994 |
An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; Cell Line; Collagen; Cricetinae; Gene Expression; Humans; Kidney; Kinetics; Molecular Sequence Data; Molecular Weight; Phorbol Esters; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Recombinant Proteins; Saliva; Salivary Proteins and Peptides; Thrombin; Thromboxane A2; Transfection; Triatominae | 1994 |
Interaction of human platelets and leukocytes in modulation of vascular tone.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Arginine; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carotid Artery, Common; Ergolines; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Muscle Tonus; Muscle, Smooth, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroarginine; Nitroprusside; Phenylephrine; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Thromboxane; Serotonin Antagonists; Superoxide Dismutase; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
Combined ADP and thromboxane A2 antagonism prevents cyclic flow variations in stenosed and endothelium-injured arteries in nonhuman primates.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Constriction, Pathologic; Coronary Vessels; Dogs; Endothelium, Vascular; Female; Femoral Artery; Hemodynamics; Humans; In Vitro Techniques; Papio; Platelet Aggregation; Regional Blood Flow; Thromboxane A2; Ticlopidine | 1993 |
Maternal and fetal platelet activation in normal pregnancy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Female; Fetal Blood; Fetus; Humans; Platelet Activation; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Regression Analysis; Thromboxane A2 | 1994 |
Mechanisms causing coronary microvascular dysfunction following crystalloid cardioplegia and reperfusion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Calcimycin; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Vessels; Endocardium; Endothelium, Vascular; Female; Heart Arrest, Induced; Male; Microcirculation; Microscopy, Electron; Muscle, Smooth, Vascular; Myocardial Reperfusion; Pericardium; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasodilation | 1993 |
Zinc ions potentiate adenosine diphosphate-induced platelet aggregation by activation of protein kinase C.
Topics: Adenosine Diphosphate; Blood Platelets; Blood Proteins; Calcium; Chelating Agents; Drug Synergism; Enzyme Activation; Ethylenediamines; Humans; Ions; Phosphoproteins; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Thiones; Thromboxane A2; Zinc | 1994 |
Indapamide inhibits endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Endothelium, Vascular; Hypertension; In Vitro Techniques; Indapamide; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred SHR; Receptors, Thromboxane; Thromboxane A2 | 1993 |
Aggregation of human and canine platelets: modulation by purine nucleotides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine Nucleotides; Adenosine Diphosphate; Animals; Collagen; Dogs; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic; Receptors, Thromboxane; Thrombin; Thromboxane A2 | 1993 |
Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes: a comparison with thrombin.
Topics: Adenosine Diphosphate; Adult; Antibodies, Monoclonal; Blotting, Western; Cathepsin G; Cathepsins; Humans; Neutrophils; Platelet Membrane Glycoproteins; Serine Endopeptidases; Thrombin; Thromboxane A2 | 1993 |
Human platelets secrete chemotactic activity for eosinophils.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Calcium; Chemotactic Factors; Chemotaxis, Leukocyte; Cytoplasmic Granules; Cytosol; Eosinophils; Humans; Platelet Activating Factor; Platelet Factor 4; Platelet Storage Pool Deficiency; Prostaglandin Endoperoxides; Thromboxane A2; Triazoles | 1993 |
An increase in phosphatidic acid in the absence of changes in diacylglycerol in human platelets stimulated with ADP.
Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Diglycerides; Humans; In Vitro Techniques; Phosphatidic Acids; Platelet Aggregation; Thrombin; Thromboxane A2; Tritium | 1993 |
Roles of platelet-activating factor, thromboxane A2, ADP and thrombin in thrombogenesis in the guinea pig.
Topics: Adenosine Diphosphate; Animals; Azepines; Biphenyl Compounds; Guinea Pigs; Heptanoic Acids; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Ticlopidine; Triazoles | 1993 |
The human platelet ADP receptor activates Gi2 proteins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Affinity Labels; Azides; Blood Platelets; Cyclic AMP; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Immunosorbent Techniques; Photochemistry; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic P2; Thrombin; Thromboxane A2 | 1995 |
Effects of ticlopidine administered to healthy volunteers on platelet function in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Cells, Cultured; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Ticlopidine | 1995 |
The hemorrhagin catrocollastatin inhibits collagen-induced platelet aggregation by binding to collagen via its disintegrin-like domain.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amino Acid Sequence; Blood Platelets; Collagen; Crotalid Venoms; Disintegrins; Humans; In Vitro Techniques; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Peptides; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Protein Binding; Sequence Homology, Amino Acid; Thromboxane A2; Tritium | 1996 |
Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Collagen; Dinoprost; F2-Isoprostanes; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Inositol Phosphates; Kidney; Kinetics; Pertussis Toxin; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Receptors, Thromboxane; Recombinant Proteins; Thrombin; Thromboxane A2; Transfection; Virulence Factors, Bordetella | 1996 |
Moderate hypothermia reduces cardiopulmonary bypass-induced impairment of cerebrovascular responses to platelet products.
Topics: Adenosine Diphosphate; Animals; Brain; Cardiopulmonary Bypass; Cerebrovascular Circulation; Complement Activation; Endothelium, Vascular; Female; Hypothermia, Induced; In Vitro Techniques; Male; Microcirculation; Microscopy, Electron; Muscle, Smooth, Vascular; Nitroprusside; Platelet Activation; Serotonin; Swine; Thromboxane A2; Vascular Resistance | 1996 |
Inhibition of ADP-induced platelet activation by 7-chloro-4-nitrobenz-2-oxa-1,3-diazole: covalent modification of aggregin, a putative ADP receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Chloro-7-nitrobenzofurazan; Adenosine; Adenosine Diphosphate; Blood Platelets; Calcimycin; Calcium; Cell Aggregation; Cell Size; Collagen; Cyclic AMP; Fibrinogen; Humans; Platelet Activation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Time Factors | 1996 |
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents | 1996 |
Platelet aggregation, sensitivity to prostaglandin E1 and thromboxane A2 release in recombinant hirudin- and heparin-anticoagulated blood.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Female; Gas Chromatography-Mass Spectrometry; Heparin; Hirudins; Humans; Male; Platelet Aggregation; Recombinant Proteins; Thromboxane A2 | 1996 |
Platelet lysis and functional perturbation by 13-methyl myristate. The major fatty acid in Flavobacterium ranacida.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Cell Membrane; Collagen; Fibrinogen; Flavobacterium; Humans; Microscopy, Electron, Scanning; Myristic Acids; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1996 |
Antithrombotic effects of peroxynitrite: inhibition and reversal of aggregation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Cyclic GMP; Humans; Nitrates; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Spectrophotometry; Thrombin; Thromboxane A2 | 1995 |
Human recombinant interleukin-1 beta induces thromboxane A2 release in polymorphonuclear leukocytes, macrophages and platelets: effect of IL-1 receptor antagonist.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcimycin; Calcium; Cell Aggregation; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Ionophores; Macrophages, Peritoneal; Neutrophils; Platelet Aggregation; Rats; Recombinant Proteins; Sialoglycoproteins; Thromboxane A2; Thromboxane B2 | 1996 |
Sevoflurane inhibits human platelet aggregation and thromboxane A2 formation, possibly by suppression of cyclooxygenase activity.
Topics: Adenosine Diphosphate; Anesthetics, Inhalation; Arachidonic Acid; Binding Sites; Drug Interactions; Epinephrine; Ethers; Halothane; Humans; Isoflurane; Methyl Ethers; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Sevoflurane; Thromboxane A2; Thromboxane B2 | 1996 |
Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Cell Adhesion Molecules; Cyclic AMP; Cytosol; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Platelet Activation; Protein-Tyrosine Kinases; Thrombin; Thromboxane A2; Tyrosine | 1996 |
Platelet activation in newborns detected by flow-cytometry.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aging; Antibodies, Monoclonal; Female; Flow Cytometry; Humans; Infant, Newborn; Male; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1996 |
A possible dual physiological role of extracellular ATP in the modulation of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Chromatography, High Pressure Liquid; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2 | 1997 |
Suppression of the voltage-gated K+ current of human megakaryocytes by thrombin and prostacyclin.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Bone Marrow; Colforsin; Cyclic AMP; Egtazic Acid; Enzyme Inhibitors; Epoprostenol; GTP-Binding Proteins; Humans; Ion Channel Gating; Megakaryocytes; Membrane Potentials; Patch-Clamp Techniques; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Receptors, Thrombin; Thrombin; Thromboxane A2 | 1997 |
Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thro
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Binding Sites; Blood Platelet Disorders; Blood Platelets; Cytoplasmic Granules; Female; Fibrinogen; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Phosphorus Radioisotopes; Platelet Aggregation; Reference Values; Serotonin; Thionucleotides; Thromboxane A2 | 1997 |
Defective signal transduction through the thromboxane A2 receptor in a patient with a mild bleeding disorder: deficiency of the inositol 1,4,5-triphosphate formation despite normal G-protein activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelet Disorders; Blood Platelets; Calcimycin; Child; Female; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Signal Transduction; Thrombin; Thromboxane A2; Type C Phospholipases | 1997 |
Combined administration of 5-HT2 and thromboxane A2 antagonists: effects on platelet aggregation and isolated cardiac muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Pressure; Dioxanes; Electrocardiography; Heart; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinolines; Rats; Rats, Wistar; Refractory Period, Electrophysiological; Serotonin Antagonists; Thromboxane A2; Vasoconstrictor Agents | 1997 |
Increased platelet aggregation due to chilling to 20 degrees C is not related to increased sensitivity to agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Analysis of Variance; Arachidonic Acid; Blood Platelets; Cold Temperature; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Thromboxane B2; Vasoconstrictor Agents | 1997 |
Blocking platelet aggregation inhibits thromboxane A2 formation by low dose agonists but does not inhibit phosphorylation and activation of cytosolic phospholipase A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Adenosine Diphosphate; Blood Platelets; Cytoplasmic Granules; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Lysophospholipids; Peptide Fragments; Phosphorylase a; Phosphorylation; Plasma; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Serotonin; Thrombasthenia; Thromboxane A2; Tyrosine; Vasoconstrictor Agents | 1997 |
Anti-thrombotic and anti-inflammatory activities of protopine.
Topics: Adenosine Diphosphate; Alkaloids; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Benzophenanthridines; Berberine Alkaloids; Blood Platelets; Carrageenan; Edema; Fibrinolytic Agents; Histamine H1 Antagonists; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats; Rats, Sprague-Dawley; Thromboxane A2 | 1997 |
Difference of (Ca2+)i movements in platelets stimulated by thrombin and TRAP: the involvement of alpha(IIb)beta3-mediated TXA2 synthesis.
Topics: Adenosine Diphosphate; Antibodies, Monoclonal; Apyrase; Aspirin; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Dipeptides; Fibrinogen; Humans; Ion Transport; Peptide Fragments; Phenylacetates; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Thrombin; Signal Transduction; Sulfonamides; Thrombin; Thromboxane A2; Thromboxane B2; Tirofiban; Tyrosine | 1998 |
Chronic dietary supplementation with L-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivo.
Topics: Adenosine Diphosphate; Animals; Aorta; Arginine; Biomarkers; Creatinine; Diet; Endothelium, Vascular; Epoprostenol; Gas Chromatography-Mass Spectrometry; Hypercholesterolemia; In Vitro Techniques; Male; Nitrates; Nitroprusside; Platelet Aggregation; Rabbits; Thromboxane A2; Thromboxane B2; Vasodilator Agents | 1998 |
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Bleeding Time; Blood Coagulation Disorders; Collagen; Female; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Shock; Thromboxane A2 | 1998 |
Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Cells, Cultured; Culture Media, Conditioned; Endothelium, Vascular; Enzyme Activation; Glutathione Peroxidase; Humans; Nitric Oxide; Platelet Aggregation; Selenium; Sodium Selenite; Thromboxane A2; Thromboxane B2 | 1999 |
Platelet dense granule secretion and aggregation in adolescents with conduct disorder: effects of marijuana use.
Topics: Adenosine Diphosphate; Adolescent; Alcoholism; Cell Communication; Cell Count; Chronic Disease; Conduct Disorder; Cytoplasmic Granules; Humans; Male; Marijuana Abuse; Platelet Aggregation; Psychiatric Status Rating Scales; Serotonin; Signal Transduction; Thromboxane A2 | 1999 |
Effects of ethanol on platelet responses associated with adhesion to collagen.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cells, Cultured; Central Nervous System Depressants; Collagen; Ethanol; Humans; Platelet Adhesiveness; Rabbits; Thromboxane A2 | 1999 |
Platelet adhesion to human brain microvascular endothelial cells in vitro. Observation with video-enhanced contrast microscopy.
Topics: Adenosine Diphosphate; Brain; Capillaries; Endothelium, Vascular; Hemostatics; Humans; In Vitro Techniques; Intracranial Thrombosis; Microscopy, Video; Platelet Adhesiveness; Thrombin; Thromboxane A2 | 1999 |
Effects of MK-447 on platelet shape change, aggregation, and ATP release by collagen, ADP, and stable analogue of thromboxane A2 in rabbit platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Butylated Hydroxytoluene; Collagen; Platelet Aggregation; Rabbits; Thromboxane A2 | 1999 |
ADP can induce aggregation of human platelets via both P2Y(1) and P(2T) receptors.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Algorithms; Binding, Competitive; Female; Humans; In Vitro Techniques; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thromboxane A2 | 2000 |
The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2000 |
Purification, cloning, expression, and mechanism of action of a novel platelet aggregation inhibitor from the salivary gland of the blood-sucking bug, Rhodnius prolixus.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Animals; Arachidonic Acid; Blood Platelets; Calcium; Cattle; Cell Adhesion; Cell Aggregation; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cloning, Molecular; Collagen; Crotalid Venoms; Cyclic AMP; DNA, Complementary; Dose-Response Relationship, Drug; Humans; Insect Proteins; Lectins, C-Type; Molecular Sequence Data; Platelet Aggregation Inhibitors; Rabbits; Rhodnius; Salivary Glands; Salivary Proteins and Peptides; Sequence Homology, Amino Acid; Thromboxane A2; Time Factors; Tryptophan | 2000 |
Comparative effects of angiotensin II AT-1-type receptor antagonists in vitro on human platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Benzimidazoles; Benzoates; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Platelet Activation; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Telmisartan; Tetrazoles; Thromboxane A2; Time Factors; Valine; Valsartan | 2000 |
Glycoprotein IIb/IIIa receptor inhibitor attenuates platelet aggregation induced by thromboxane A2 during in vitro nonpulsatile ventricular assist circulation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Analysis of Variance; Anti-Bacterial Agents; Blood Platelets; Cell Degranulation; Collagen; Heart-Assist Devices; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Ristocetin; Thromboxane A2; Tirofiban; Tyrosine | 2000 |
Habitual smoking causes an abnormality in platelet thromboxane A2 metabolism and results in an altered susceptibility to aspirin effects.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Aspirin; Blood Platelets; Collagen; Epoprostenol; Erythrocytes; Humans; Male; Platelet Aggregation; Smoking; Thromboxane A2; Thromboxanes | 2000 |
Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin alpha IIbbeta 3. Studies in human platelets ans transfected Chinese hamster ovary cells.
Topics: Adenosine Diphosphate; Animals; Calcium; Cell Adhesion; CHO Cells; Cricetinae; Egtazic Acid; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Thromboxane A2; Transfection; von Willebrand Factor | 2000 |
Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Statistics, Nonparametric; Thrombin; Thromboxane A2 | 2000 |
The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Annexin A5; Aspirin; Blood Platelets; Calcium; Collagen; Cytosol; Fibrinolytic Agents; Flow Cytometry; Humans; Membrane Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Stimulation, Chemical; Thromboxane A2 | 2000 |
Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heteroz
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Blood Platelet Disorders; Blood Platelets; Cytoplasmic Granules; Female; Genetic Carrier Screening; Humans; Male; Middle Aged; Platelet Aggregation; Receptors, Purinergic P2; Thromboxane A2 | 2000 |
Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.
Topics: Adenosine Diphosphate; Blood Platelets; Cell Communication; Enzyme Inhibitors; Epoprostenol; Fibrosarcoma; Gelatinases; Glutathione; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasms, Experimental; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Penicillamine; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Thromboxane A2; Tumor Cells, Cultured | 2001 |
Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Cyclic AMP; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Serotonin; Signal Transduction; Thromboxane A2 | 2001 |
Pathogenetic analysis of three cases with a bleeding disorder characterized by defective platelet aggregation induced by Ca2+ ionophores.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Blood Platelet Disorders; Blood Proteins; Calcimycin; Calcium; Collagen; Female; Humans; Ionophores; Male; Middle Aged; Myosin Light Chains; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Ristocetin; Thrombin; Thromboxane A2 | 2001 |
Signalling events underlying platelet aggregation induced by the glycoprotein VI agonist convulxin.
Topics: Adenosine Diphosphate; Animals; Apyrase; CD36 Antigens; Crotalid Venoms; Drug Synergism; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Indomethacin; Lectins, C-Type; Mice; Phosphatidic Acids; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Serotonin; Signal Transduction; Thromboxane A2 | 2001 |
Local anesthetic actions on thromboxane-induced platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amides; Anesthetics, Local; Bupivacaine; Humans; Lidocaine; Platelet Aggregation; Ropivacaine; Thromboxane A2 | 2001 |
Synergistic outside-in regulation of platelet activation by GPIIb/IIIa ligand-induced conformation and oligomerization.
Topics: Acetates; Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Binding Sites; Cricetinae; Cross-Linking Reagents; Dimerization; Drug Synergism; Ligands; Oligopeptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Conformation; Serotonin; Signal Transduction; Thromboxane A2; Tyrosine | 2001 |
Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; Humans; Membrane Proteins; Phospholipases A; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Thromboxane A2 | 2002 |
Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cytoplasmic Granules; In Vitro Techniques; Kinetics; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; src-Family Kinases; Thrombin; Thromboxane A2 | 2002 |
The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate; Anticoagulants; Arachidonic Acids; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated; Heparin; Humans; Hydrazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane A2 | 2002 |
The roles of LAT in platelet signaling induced by collagen, TxA2, or ADP.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adaptor Proteins, Signal Transducing; Adenosine Diphosphate; Animals; Antibodies; Arachidonic Acid; Blood Platelets; Carrier Proteins; Collagen; Dose-Response Relationship, Drug; Membrane Proteins; Mice; Mice, Knockout; Phosphoproteins; Platelet Aggregation; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2002 |
Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP.
Topics: Adenosine Diphosphate; Calcium; Carrier Proteins; Collagen; Crotalid Venoms; GTP-Binding Proteins; Humans; Lectins, C-Type; Peptides; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Kinase C; Second Messenger Systems; Thromboxane A2 | 2002 |
Losartan inhibits in vitro platelet activation: comparison with candesartan and valsartan.
Topics: Adenosine Diphosphate; Adult; Angiotensin Receptor Antagonists; Benzimidazoles; Biphenyl Compounds; Blood Platelets; Cells, Cultured; Drug Interactions; Humans; Losartan; Male; Platelet Activation; Platelet Aggregation Inhibitors; Receptor, Angiotensin, Type 1; Tetrazoles; Thromboxane A2; Valine; Valsartan | 2000 |
Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Humans; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thromboxane A2 | 2002 |
Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens.
Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Blood Platelets; Cattle; CD36 Antigens; Cell Size; Collagen; Feedback, Physiological; Humans; In Vitro Techniques; Integrin alpha2beta1; Membrane Proteins; Mice; Microscopy, Electron; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Purinergic P2 Receptor Antagonists; Receptors, Collagen; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thromboxane A2 | 2002 |
Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Collagen; DNA-Binding Proteins; Dose-Response Relationship, Drug; Fibrinogen; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Serine-Threonine Kinases; rho-Associated Kinases; Signal Transduction; Thrombin; Thromboxane A2 | 2002 |
Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Cells, Cultured; Dual Specificity Phosphatase 2; Egtazic Acid; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Integrin alpha1beta1; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Receptors, Fibrinogen; Signal Transduction; Thromboxane A2 | 2002 |
Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Chelating Agents; Cyclic AMP; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Epinephrine; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinase 1; Models, Biological; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; rho-Associated Kinases; Signal Transduction; Thromboxane A2 | 2002 |
The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.
Topics: Adenosine Diphosphate; Animals; Collagen; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Kinetics; Mice; Phospholipase C gamma; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thromboxane A2; Type C Phospholipases | 2003 |
Complementary roles of glycoprotein VI and alpha2beta1 integrin in collagen-induced thrombus formation in flowing whole blood ex vivo.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Collagen; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Integrin alpha2beta1; Mice; Mice, Knockout; Platelet Adhesiveness; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, IgG; Thrombosis; Thromboxane A2 | 2003 |
The effect of submaximal exercise on platelet aggregation during late follicular and midluteal phases in women.
Topics: Adenosine Diphosphate; Adult; Arteriosclerosis; Collagen; Estradiol; Exercise; Female; Follicular Phase; Humans; In Vitro Techniques; Luteal Phase; Platelet Aggregation; Progesterone; Thromboxane A2; Thromboxane B2 | 2002 |
Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Cattle; Collagen; Enzyme Activation; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Integrin alpha2beta1; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2 | 2004 |
The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Cell Shape; Collagen; Drug Synergism; GTP-Binding Protein alpha Subunits, Gq-G11; Kinetics; Mice; Mice, Knockout; Microscopy, Electron, Scanning; Platelet Activation; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2 | 2004 |
Different G protein-coupled signaling pathways are involved in alpha granule release from human platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Cytoplasmic Granules; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Membrane Proteins; Receptors, G-Protein-Coupled; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Secretory Vesicles; Signal Transduction; Thromboxane A2 | 2004 |
ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Enzyme Activation; Epinephrine; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; In Vitro Techniques; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thrombin; Thromboxane A2 | 2004 |
Platelet adhesion and signaling induced by the octapeptide primary binding sequence (KOGEOGPK) from type III collagen.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Animals; Blood Platelets; Cations, Divalent; Cattle; Collagen Type III; Crotalid Venoms; Cyclooxygenase Inhibitors; Enzyme Precursors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Lectins, C-Type; Peptides; Phospholipase C gamma; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Subunits; Protein-Tyrosine Kinases; Purinergic P2 Receptor Antagonists; Receptors, Collagen; Receptors, Purinergic P2; Signal Transduction; Syk Kinase; Thromboxane A2; Type C Phospholipases | 2004 |
Differential roles of integrins alpha2beta1 and alphaIIbbeta3 in collagen and CRP-induced platelet activation.
Topics: Adenosine Diphosphate; Benzodiazepines; Carrier Proteins; Collagen; Cytoplasmic Granules; Dual Specificity Phosphatase 2; Humans; Integrin alpha2beta1; P-Selectin; Peptides; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet Membrane Glycoproteins; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Thromboxane A2 | 2004 |
The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Cell Adhesion; Crotalid Venoms; GTP-Binding Protein alpha Subunits, Gq-G11; Mice; Mice, Transgenic; Models, Biological; Phospholipases A; Phospholipases A2; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Quinacrine; Receptors, Thromboxane A2, Prostaglandin H2; Recombinant Proteins; Signal Transduction; Thromboxane A2; Time Factors; von Willebrand Factor | 2004 |
Glucosamine, a naturally occurring amino monosaccharide, suppresses the ADP-mediated platelet activation in humans.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amination; Blood Platelets; Calcium; Enzyme Precursors; Glucosamine; Humans; Intracellular Signaling Peptides and Proteins; Monosaccharides; Phosphorylation; Platelet Activation; Platelet Factor 4; Protein-Tyrosine Kinases; Receptors, Purinergic P2; Syk Kinase; Thromboxane A2 | 2004 |
Correlation between in vitro aggregation and thromboxane A2 production in fresh, liquid-preserved, and cryopreserved human platelets: effect of agonists, pH, and plasma and saline resuspension.
Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Blood Preservation; Cryopreservation; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Plasma; Platelet Aggregation; Platelet Transfusion; Sodium Chloride; Thromboxane A2 | 2005 |
Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Androstadienes; Antibodies, Monoclonal; Blood Platelets; Blood Proteins; Calcium; Chromones; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Proto-Oncogene Proteins; rap GTP-Binding Proteins; Receptors, Cytokine; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Thrombopoietin; Thrombopoietin; Thromboxane A2; Thromboxanes; Time Factors; Type C Phospholipases; Wortmannin | 2005 |
Influence of extracellular calcium on single platelet activation as measured by whole blood flow cytometry.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Calcium; Female; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Thromboxane A2 | 2005 |
Regulation of platelet guanylyl cyclase by collagen: evidence that Glycoprotein VI mediates platelet nitric oxide synthesis in response to collagen.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Citrulline; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Fibrinogen; Guanylate Cyclase; Humans; Immunoblotting; Immunoprecipitation; Nitric Oxide; Nitric Oxide Synthase; Peptides; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Membrane Glycoproteins; Protein Kinase C; Signal Transduction; src-Family Kinases; Thromboxane A2 | 2005 |
Patients with platelet dysfunction characterized by transient and reversible aggregation in response to ADP despite normal collagen-induced aggregation.
Topics: Adenosine Diphosphate; Adult; Blood Platelet Disorders; Collagen; Female; Humans; Platelet Aggregation; Pregnancy; Siblings; Thromboxane A2 | 2005 |
Arf6 plays an early role in platelet activation by collagen and convulxin.
Topics: Adenosine Diphosphate; ADP-Ribosylation Factor 1; ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Calcium Signaling; cdc42 GTP-Binding Protein; Cell Membrane; Collagen; Crotalid Venoms; Cytoskeleton; Enzyme Activation; Humans; Lectins, C-Type; Platelet Adhesiveness; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; rap1 GTP-Binding Proteins; rhoA GTP-Binding Protein; Thromboxane A2 | 2006 |
Inhibitory action of glucosamine on platelet activation in guinea pigs.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Animals; Bleeding Time; Blood Platelets; Body Weight; Cytoplasmic Granules; Female; Glucosamine; Guinea Pigs; Platelet Activation; Platelet Aggregation; Platelet Count; Receptors, Purinergic P2; Thromboxane A2 | 2005 |
Prostaglandin A1 inhibits increases in intracellular calcium concentration, TXA(2) production and platelet activation.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Collagen; Humans; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins A; Serotonin; Thrombin; Thromboxane A2 | 2006 |
G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cytoplasmic Granules; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Humans; Mice; Phospholipases A; Platelet Aggregation; Potassium Channel Blockers; Reference Values; src-Family Kinases; Thromboxane A2 | 2006 |
Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Humans; p38 Mitogen-Activated Protein Kinases; Thrombin; Thromboxane A2 | 2007 |
Von Willebrand factor activates endothelial nitric oxide synthase in blood platelets by a glycoprotein Ib-dependent mechanism.
Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Cell Adhesion Molecules; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; In Vitro Techniques; Microfilament Proteins; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Signal Transduction; src-Family Kinases; Thromboxane A2; von Willebrand Factor | 2006 |
Activation and impairment of platelet function in vitro by fatty acid ethyl ester, a nonoxidative ethanol metabolite: effect of fatty acid ethyl esters on human platelets.
Topics: Adenosine Diphosphate; Arachidonic Acid; beta-Thromboglobulin; Blood Platelets; Central Nervous System Depressants; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Esters; Ethanol; Fatty Acids; Humans; In Vitro Techniques; Oleic Acids; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Thromboxane A2; Time Factors | 2006 |
Effect of physiologic shear stresses and calcium on agonist-induced platelet aggregation, secretion, and thromboxane A2 formation.
Topics: Adenosine Diphosphate; Adult; Anticoagulants; Blood Platelets; Calcium; Citric Acid; Dose-Response Relationship, Drug; Hemostatics; Humans; In Vitro Techniques; Platelet Aggregation; Platelet-Rich Plasma; Protein Kinase C-delta; Secretory Vesicles; Serotonin; Stress, Mechanical; Thrombin; Thromboxane A2 | 2007 |
Primary and secondary agonists can use P2X(1) receptors as a major pathway to increase intracellular Ca(2+) in the human platelet.
Topics: Adenosine Diphosphate; Benzenesulfonates; Blood Platelets; Calcium; Humans; Luminescence; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2X; Spectrometry, Fluorescence; Thromboxane A2 | 2007 |
The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Fibrinogen; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Platelet Adhesiveness; Platelet Glycoprotein GPIb-IX Complex; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Syk Kinase; Thromboxane A2; von Willebrand Factor | 2008 |
Dual effect of nitrate therapy for cyclosporine-induced hypertension on vascular and platelet morphofunctional markers; an animal model.
Topics: Adenosine Diphosphate; Animals; Aorta; Blood Platelets; Blood Pressure; Cyclosporine; Epoprostenol; Hypertension; Lipids; Male; Models, Animal; Nitrates; Platelet Aggregation; Rats; Rats, Wistar; Thromboxane A2 | 2007 |
Platelet pro-aggregatory effects of CD40L monoclonal antibody.
Topics: Adenosine Diphosphate; Animals; Antibodies, Monoclonal; Aspirin; Blood Platelets; Calcium; CD40 Antigens; CD40 Ligand; Chelating Agents; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Swine; Thromboxane A2 | 2008 |
A high concentration of ADP induces weak platelet granule secretion independently of aggregation and thromboxane A2 production.
Topics: Adenosine Diphosphate; Blood Platelets; Cytoplasmic Granules; Humans; Platelet Aggregation; Thromboxane A2 | 2007 |
Alteration of release and role of adenosine diphosphate and thromboxane A2 during collagen-induced aggregation of platelets from cattle with Chediak-Higashi syndrome.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Cells, Cultured; Chediak-Higashi Syndrome; Collagen; Dose-Response Relationship, Drug; Drug Synergism; Platelet Aggregation; Thromboxane A2 | 2007 |
Prognostic significance of platelet function in the early phase of ST-elevation myocardial infarction treated with primary angioplasty.
Topics: Adenosine Diphosphate; Adrenergic Agonists; Aged; Blood Platelets; Collagen; Epinephrine; Female; Humans; In Vitro Techniques; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Platelet Activation; Stents; Thromboxane A2; Ventricular Function, Left | 2008 |
Oncocalyxone A inhibits human platelet aggregation by increasing cGMP and by binding to GP Ibalpha glycoprotein.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Anthraquinones; Blood Platelets; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Flow Cytometry; Guanylate Cyclase; Humans; In Vitro Techniques; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Protein Binding; Thromboxane A2 | 2008 |
Role of membrane cholesterol in platelet calcium signalling in response to VWF and collagen under stasis and flow.
Topics: Adenosine Diphosphate; Antigens, CD; Autocrine Communication; beta-Cyclodextrins; Blood Platelets; Calcium Signaling; Cell Membrane; Cholesterol; Collagen Type III; Hemorheology; Humans; Microscopy, Confocal; P-Selectin; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Transport; Receptors, Collagen; Secretory Vesicles; Stress, Mechanical; Tetraspanin 30; Thromboxane A2; Time Factors; Tyrosine; von Willebrand Factor | 2008 |
The prevalence of the platelet glycoprotein IIIa Pl(A1/A2) polymorphism in three South African ethnic groups and its effect on platelet function.
Topics: Adenosine Diphosphate; Alleles; Blood Platelets; Collagen; Coronary Artery Disease; Dose-Response Relationship, Drug; Ethnicity; Female; Gene Frequency; Genotype; Humans; Integrin beta3; Male; Platelet Aggregation; Polymorphism, Genetic; Prevalence; South Africa; Thromboxane A2; Urban Population | 2008 |
Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Collagen; Flavonoids; Fruit; Glycosides; In Vitro Techniques; Magnetic Resonance Spectroscopy; Plant Leaves; Plant Stems; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sophora; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thromboxane A2 | 2008 |
The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Blood Proteins; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thromboxane A2 | 2008 |
Nitric oxide specifically inhibits integrin-mediated platelet adhesion and spreading on collagen.
Topics: Adenosine Diphosphate; Blood Platelets; Cells, Cultured; Collagen; Humans; Integrin alpha2beta1; Integrins; Nitric Oxide; Peptides; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Protein Binding; S-Nitrosoglutathione; Thromboxane A2 | 2008 |
Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2.
Topics: Adenosine Diphosphate; Blood Platelets; Collagen; Down-Regulation; Humans; LDL-Receptor Related Proteins; Lipoproteins, LDL; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Platelet Endothelial Cell Adhesion Molecule-1; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Receptors, Lipoprotein; Receptors, Thrombin; Signal Transduction; Thromboxane A2; Time Factors | 2009 |
CalDAG-GEFI is at the nexus of calcium-dependent platelet activation.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Blotting, Western; Calcium; Cell Proliferation; Collagen; Diglycerides; Female; Flow Cytometry; Guanine Nucleotide Exchange Factors; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Platelet Membrane Glycoproteins; rap1 GTP-Binding Proteins; Serotonin; Thromboxane A2 | 2009 |
Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases.
Topics: Adenosine Diphosphate; Blood Platelets; Collagen; Fibrinogen; Humans; Integrins; Phosphatidylinositol 3-Kinases; Platelet Adhesiveness; Protein Kinase Inhibitors; Protein Kinases; Quercetin; Signal Transduction; Thromboxane A2 | 2010 |
Normal filopodia extension in VASP-deficient platelets upon activation by adhesive matrices or soluble agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Extracellular Matrix; Fibrinogen; Hemostasis; Mice; Mice, Knockout; Microfilament Proteins; Phosphoproteins; Platelet Activation; Pseudopodia; Thromboxane A2; von Willebrand Factor | 2009 |
Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Class I Phosphatidylinositol 3-Kinases; Clot Retraction; Cytoskeleton; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Stress, Mechanical; Thrombin; Thromboxane A2 | 2010 |
L-4F alters hyperlipidemic (but not healthy) mouse plasma to reduce platelet aggregation.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Adenosine Diphosphate; Animals; Apolipoprotein A-I; Apolipoproteins E; Arachidonic Acid; Blood Coagulation; Collagen; Dinoprostone; Disease Models, Animal; Hyperlipidemias; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Mimicry; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin D2; Receptors, LDL; Thromboxane A2 | 2010 |
Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac.
Topics: Actins; Adenosine Diphosphate; Amino Acid Motifs; Blood Platelets; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Lectins, C-Type; Membrane Glycoproteins; Membrane Microdomains; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Transport; Protein-Tyrosine Kinases; rac1 GTP-Binding Protein; src-Family Kinases; Syk Kinase; Thromboxane A2 | 2010 |
An important role of the SRC family kinase Lyn in stimulating platelet granule secretion.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cell Degranulation; Collagen; Guanosine Monophosphate; Humans; Mice; Mice, Knockout; Nitric Oxide; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Pyrimidines; Secretory Vesicles; Signal Transduction; src-Family Kinases; Thrombin; Thromboxane A2 | 2010 |
Fibrinogen interaction with human platelets: effect of other coagulation factors, prostaglandins and platelet inhibitors.
Topics: Adenosine Diphosphate; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Fibrinogen; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Receptors, Fibrinogen; Recombinant Proteins; Thromboxane A2 | 1983 |
Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; In Vitro Techniques; Isoenzymes; MAP Kinase Signaling System; Mice; Mice, Knockout; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Protein Kinase Inhibitors; Pyrimidinones; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2 | 2010 |
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
Antiplatelet effects of Spatholobus suberectus via inhibition of the glycoprotein IIb/IIIa receptor.
Topics: Adenosine Diphosphate; Animals; Asia, Eastern; Collagen; Dose-Response Relationship, Drug; Epinephrine; Fabaceae; Female; Fibrinogen; Humans; Mice; Mice, Inbred ICR; Phytotherapy; Plant Extracts; Plant Stems; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Platelet-Rich Plasma; Thromboembolism; Thromboxane A2 | 2011 |
Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.
Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Humans; Platelet Aggregation; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Intracellular Signaling Peptides and Proteins; Mice; Platelet Glycoprotein GPIIb-IIIa Complex; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); rho-Associated Kinases; Signal Transduction; Syk Kinase; Thromboxane A2 | 2011 |
Ent-16β,17-dihydroxy-kauran-19-oic acid, a kaurane diterpene acid from Siegesbeckia pubescens, presents antiplatelet and antithrombotic effects in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Animals; Asteraceae; Coronary Thrombosis; Cyclic AMP; Diterpenes, Kaurane; Epoprostenol; Female; Fibrinolytic Agents; Hemorrhage; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Thrombin; Thromboxane A2; Thyroglobulin | 2011 |
G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Carrier Proteins; Fetal Proteins; Formins; Humans; Kinetics; Mice; Mice, Knockout; Nuclear Proteins; Peptides; Phosphorylation; Protein Kinase Inhibitors; Receptors, G-Protein-Coupled; rho-Associated Kinases; Thrombin; Thromboxane A2 | 2011 |
Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis.
Topics: Adenosine Diphosphate; Angiogenesis Modulating Agents; Aspirin; Blood Platelets; Breast Neoplasms; Carcinoma; Cells, Cultured; Endostatins; Endothelial Cells; Female; Humans; Models, Biological; Neovascularization, Pathologic; Neovascularization, Physiologic; Secretory Vesicles; Thromboxane A2; Vascular Endothelial Growth Factor A | 2011 |
A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Collagen; Cyclic GMP; Diterpenes; Humans; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type III; Platelet Activation; Platelet Aggregation Inhibitors; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Embolism; Thromboxane A2 | 2011 |
Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Collagen; Humans; Image Interpretation, Computer-Assisted; Light; Mice; Middle Aged; Platelet Aggregation; Platelet Function Tests; Platelet-Rich Plasma; Receptors, Purinergic P2; Scattering, Radiation; Thromboxane A2 | 2012 |
Blood clots are rapidly assembled hemodynamic sensors: flow arrest triggers intraluminal thrombus contraction.
Topics: Adenosine Diphosphate; Blood Coagulation; Blood Platelets; Calcium; Cardiovascular Physiological Phenomena; Collagen; Equipment Design; Hemodynamics; Heterocyclic Compounds, 4 or More Rings; Humans; In Vitro Techniques; Microfluidic Analytical Techniques; Nonmuscle Myosin Type IIA; Regional Blood Flow; Signal Transduction; Thrombosis; Thromboxane A2 | 2012 |
Antiplatelet activity of L-sulforaphane by regulation of platelet activation factors, glycoprotein IIb/IIIa and thromboxane A2.
Topics: Adenosine Diphosphate; Animals; Blood Coagulation; Blood Platelets; Collagen; Female; Fibrinolytic Agents; Humans; Isothiocyanates; Mice; Mice, Inbred ICR; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pulmonary Embolism; Sulfoxides; Thiocyanates; Thrombin; Thromboxane A2 | 2013 |
Cholesterol enrichment of rabbit platelets enhances the Ca(2+) entry pathway induced by platelet-derived secondary feedback agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Cholesterol; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; Male; Rabbits; Thrombin; Thromboxane A2; Thromboxane B2 | 2013 |
Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thionucleotides; Thromboxane A2; Time Factors; Tyrphostins | 2013 |
Thromboelastography platelet mapping in healthy dogs using 1 analyzer versus 2 analyzers.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Dogs; Female; Fibrin; Male; Platelet Aggregation; Statistics, Nonparametric; Thrombelastography; Thrombin; Thromboxane A2 | 2013 |
Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
Topics: Adenosine Diphosphate; Animals; Autocrine Communication; Blood Platelets; Leukotriene C4; Leukotriene D4; Leukotriene E4; Mice; Mice, Knockout; Ovalbumin; P-Selectin; Platelet Activation; Platelet Factor 4; Platelet-Rich Plasma; Pulmonary Eosinophilia; Receptors, Leukotriene; Receptors, Purinergic P2; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2 | 2013 |
The sex specific effects of extraneous testosterone on ADP induced platelet aggregation in platelet-rich plasma from male and female subjects.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cells, Cultured; Female; Humans; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation; Platelet Function Tests; Platelet-Rich Plasma; Sex Factors; Testosterone; Thromboxane A2 | 2014 |
Amplification of bacteria-induced platelet activation is triggered by FcγRIIA, integrin αIIbβ3, and platelet factor 4.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Host-Pathogen Interactions; Humans; Mice; Mice, Transgenic; Platelet Activation; Platelet Factor 4; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, IgG; Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus; Thromboxane A2 | 2014 |
Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses.
Topics: Adenosine Diphosphate; Adult; Apolipoprotein B-100; Blood Platelets; Cell Communication; Cells, Cultured; Coculture Techniques; Cytokines; Human Umbilical Vein Endothelial Cells; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Leukocytes; Platelet Activation; Platelet Adhesiveness; Receptors, Purinergic P2Y12; Signal Transduction; Thromboxane A2; Time Factors; Young Adult | 2014 |
Cordycepin-enriched WIB801C from Cordyceps militaris inhibits ADP-induced [Ca(2+)] i mobilization and fibrinogen binding via phosphorylation of IP 3R and VASP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Calcium Signaling; Cell Adhesion Molecules; Cordyceps; Cyclic AMP; Cyclooxygenase 1; Deoxyadenosines; Dose-Response Relationship, Drug; Fibrinogen; Herb-Drug Interactions; Humans; Inositol 1,4,5-Trisphosphate Receptors; Microfilament Proteins; Phosphoproteins; Phosphorylation; Plant Extracts; Platelet Aggregation; Platelet Aggregation Inhibitors; Thionucleotides; Thromboxane A2; Thromboxane-A Synthase | 2015 |
The role of inhibition of nitric oxide synthesis in the aggregation of platelets due to the stimulated production of thromboxane A2.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cells, Cultured; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Female; Humans; Kinetics; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Aggregation; Thromboxane A2 | 2014 |
SDF-1α is a novel autocrine activator of platelets operating through its receptor CXCR4.
Topics: Adenosine Diphosphate; Animals; Autocrine Communication; Blood Platelets; Calcium Signaling; Chemokine CXCL12; Collagen; Cyclic AMP; Horses; Humans; Platelet Activation; Platelet Aggregation; Receptors, CXCR4; Thrombosis; Thromboxane A2 | 2015 |
Group VIB calcium-independent phospholipase A2 (iPLA2γ) regulates platelet activation, hemostasis and thrombosis in mice.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Collagen; Disease Susceptibility; Group VI Phospholipases A2; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Platelet Activation; Platelet Aggregation; Receptors, Purinergic P2Y; Serotonin; Signal Transduction; Spectrometry, Mass, Electrospray Ionization; Thrombosis; Thromboxane A2 | 2014 |
DL-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2 synthesis and phosphodiesterase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium; Collagen; Cyclic AMP; Humans; Phospholipases A2, Cytosolic; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2 | 2015 |
Platelet mechanosensing of collagen matrices.
Topics: Acrylic Resins; Actomyosin; Adenosine Diphosphate; Blood Coagulation; Blood Platelets; Calcium; Collagen; Collagen Type I; Humans; Platelet Adhesiveness; Thromboxane A2 | 2015 |
Cross talk between serine/threonine and tyrosine kinases regulates ADP-induced thromboxane generation in platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Humans; Isoenzymes; Mice, Knockout; Phosphorylation; Platelet Activation; Protein Kinase C; Protein Kinase Inhibitors; Purinergic P2Y Receptor Agonists; Receptors, Purinergic P2Y1; Signal Transduction; src-Family Kinases; Thromboxane A2 | 2015 |
Platelet dense granule secretion defects may obscure α-granule secretion mechanisms: evidence from Munc13-4-deficient platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Cytoplasmic Granules; Exocytosis; Membrane Proteins; Mice; Mice, Knockout; Platelet Aggregation; Platelet Factor 4; Receptors, Purinergic P2Y12; Secretory Vesicles; Signal Transduction; Thromboxane A2 | 2015 |
Drospirenone enhances GPIb-IX-V-mediated platelet activation.
Topics: Adenosine Diphosphate; Androstenes; Apyrase; Blood Coagulation; Blood Coagulation Tests; Blood Platelets; Contraceptive Agents, Female; Cyclooxygenase Inhibitors; Humans; Indomethacin; Membrane Proteins; Platelet Activation; Platelet Glycoprotein GPIb-IX Complex; Receptors, Progesterone; Thromboxane A2; von Willebrand Factor | 2015 |
N2 extenuates experimental ischemic stroke through platelet aggregation inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arteriovenous Shunt, Surgical; Blood Coagulation; Brain; Brain Ischemia; Edema; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Female; Imidazoles; Male; Maze Learning; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Stroke; Thrombosis; Thromboxane A2; Vanillic Acid | 2015 |
Human platelet activation by Escherichia coli: roles for FcγRIIA and integrin αIIbβ3.
Topics: Adenosine Diphosphate; Blood Platelets; Escherichia coli; Humans; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Receptors, IgG; src-Family Kinases; Syk Kinase; Thromboxane A2 | 2016 |
Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Disease Models, Animal; Gene Expression; Hemostasis; Humans; Mice; Mice, Knockout; Phosphatidylserines; Phosphorylation; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Thrombin; Thrombosis; Thromboxane A2 | 2017 |
Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Glucosides; Glycogen Synthase Kinase 3 beta; Hydrazines; Luteolin; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Thromboxane A2; Tritium | 2018 |
Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cyclic AMP; Epoprostenol; Humans; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, PAR-1; Receptors, G-Protein-Coupled; Receptors, Thrombin; Signal Transduction; Thrombin; Thromboxane A2 | 2019 |
Canine platelets express functional Toll-like receptor-4: lipopolysaccharide-triggered platelet activation is dependent on adenosine diphosphate and thromboxane A2 in dogs.
Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Platelets; Dogs; Lipopolysaccharides; Platelet Activation; Rhodobacter sphaeroides; Thromboxane A2; Toll-Like Receptor 4 | 2019 |
Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Female; G-Protein-Coupled Receptor Kinases; Gene Expression Regulation; Hemostatics; Male; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Activation; Platelet Aggregation; Receptors, G-Protein-Coupled; Thionucleotides; Thrombin; Thromboxane A2 | 2020 |