Page last updated: 2024-08-17

adenosine diphosphate and thiophenes

adenosine diphosphate has been researched along with thiophenes in 93 studies

Research

Studies (93)

Timeframe	Studies, this research(%)	All Research%
pre-1990	42 (45.16)	18.7374
1990's	3 (3.23)	18.2507
2000's	21 (22.58)	29.6817
2010's	26 (27.96)	24.3611
2020's	1 (1.08)	2.80

Authors

Authors	Studies
Allain, P; Leblondel, G	1
Dechavanne, M; Ghazi, I; Lagarde, M	1
Abiko, Y; Ashida, SI	1
David, JL; Herion, F; Monfort, F; Raskinet, R	1
Gormsen, J; Knudsen, JB	1
Etherington, MD; O'Brien, JR; Shuttleworth, RD	1
Blanchard, JF; Blatrix, CE; Panak, EA; Thebault, JJ	1
De Clerck, F; Reneman, R; Vermylen, J	2
Abou-Khalil, S; Abou-Khalil, WH; Yunis, AA	1
Capecchi, PL; Ceccatelli, L; Di Perri, T; Laghi Pasini, F; Orrico, A; Pasqui, AL	1
Aurousseau, M; Benveniste, J; Chignard, M; Greiss, M; Lalau Keraly, C; Maamer, M	1
Akiyama, K; Endo, K; Kobayashi, S; Kohata, K; Mori, M; Morita, A	1
Lecompte, T; Lecrubier, C; Potevin, F; Samama, M	1
Bravo, L; Corral, C; Darias, V; Fraile, C; Lissavetzky, J; Martin-Herrera, D	1
Almirall, L; Bastida, E; Escolar, G; Ordinas, A	1
Berglund, U; von Schenck, H; Wallentin, L	1
Cohn, M; Eldor, A; Matzner, Y	1
Chou, SC; Conklin, KA	1
Rozenberg, MC; Walker, CM	1
Ackles, KN; Inwood, MJ; Philp, RB; Radomski, MW	1
Hampton, JR; Harrison, MJ; Honour, AJ; Mitchell, JR; Prichard, JS	1
Douglas, AS; McNicol, GP; Slater, SD; Turpie, AG	1
Caen, JP; Dunn, FW; Lee, H; Soria, C; Soria, J; Thomaidis, A	1
Abbate, R; Breschi, C; Costanzo, G; Favilla, S; Gensini, GF; Neri Serneri, GG	1
Picard-Fraire, C	1
Bruno, JJ	1
Baarsma, GS; Henkes, HE; Houtsmuller, AJ; Klompe, M; Tijssen, J; Vermeulen, JA; Zahn, KJ	1
Mirouze, J	1
Butler, KD; White, AM	1
Pinon, JF	1
Hanson, SR; Harker, LA	1
Girard, P; Lecrubier, C; Noire, P; Samama, M	1
Bertelé, V; de Gaetano, G	1
Bando, H; Tsubura, E; Yamashita, T	1
Benveniste, J; Chignard, M; Delabassee, D; Delautier, D; Lalau Keraly, C	1
Chevolet, C; Dresse, A; Grosdent, JC; Reiters, GM	1
Lefort, J; Randon, J; Vargaftig, BB	1
Blanchard, J; Blatrix, C; Panak, E; Thébault, J	1
Aubert, D; Ferrand, C; Loubrie, JC; Tuong, A; Tuong, CC	1
Lindsay, R; Nunn, B	1
Jogestrand, T; Johnsson, H; Kirstein, P; Olsson, AG	1
Hamada, Y; Hara, T; Inukai, S; Koh, N; Nakamura, J; Nakashima, E; Naruse, K; Sakakibara, F; Sasaki, H; Takeuchi, N	1
Inaba, H; Kosuge, K; Mizuno, A; Nagashima, S; Nakashima, M; Uematsu, T	1
Fukasawa, H; Hamada, Y; Hara, T; Hotta, N; Inukai, S; Kasama, N; Koh, N; Nakamura, J; Sakakibara, F; Takeuchi, N	1
Asai, F; Inoue, T; Koike, H; Ogawa, T; Sugidachi, A	1
Asai, F; Iwamura, R; Koike, H; Ogawa, T; Otsuguro, K; Sugidachi, A; Yoneda, K	1
Asai, F; Jakubowski, JA; Niitsu, Y; Sugidachi, A	1
Brandt, JT; Farid, NA; Jakubowski, JA; Li, GY; Naganuma, H; Payne, CD; Small, DS; Weerakkody, GJ; Winters, KJ	1
Asai, F; Brandt, JT; Freestone, S; Hirota, T; Jakubowski, JA; Matsushima, N; Naganuma, H; Winters, KJ	1
Bliden, KP; Gurbel, PA; Tantry, US	1
Brandt, JT; Farid, NA; Jakubowski, JA; Lachno, DR; Li, YG; Naganuma, H; Payne, CD; Weerakkody, GJ; Winters, KJ	1
Asai, F; Hagihara, K; Hashimoto, M; Jakubowski, JA; Kurihara, A; Niitsu, Y; Ogawa, T; Sugidachi, A	1
Barnard, MR; Fox, ML; Frelinger, AL; Furman, MI; Jakubowski, JA; Li, Y; Linden, MD; Michelson, AD; Sugidachi, A; Winters, KJ	1
Brandt, JT; Jakubowski, JA; Naganuma, H; Payne, CD; Weerakkody, GJ; Winters, KJ	1
Barnard, MR; Fox, ML; Frelinger, AL; Furman, MI; Jakubowski, JA; Li, Y; Linden, MD; Michelson, AD; Sugidachi, A; Tarnow, I; Winters, KJ	1
Brandt, JT; Ernest, CS; Farid, NA; Jakubowski, JA; Li, YG; Payne, CD; Salazar, DE; Small, DS; Winters, KJ	1
Brandt, JT; Farid, NA; Jakubowski, JA; Li, YG; Payne, CD; Salazar, DE; Small, DS; Winters, KJ	2
Brandt, JT; Farid, NA; Li, YG; Payne, CD; Salazar, DE; Small, DS; Weerakkody, GJ; Winters, KJ	1
Dovlatova, NL; Heptinstall, S; Jakubowski, JA; Sugidachi, A	1
Dovlatova, N; Heptinstall, S; Johnson, A	1
Crain, EJ; Hua, J; Rehfuss, R; Schumacher, WA; Watson, CA; Wong, PC	1
Angiolillo, DJ; Antman, EM; Braunwald, E; Downey, WE; Frelinger, AL; Jakubowski, JA; Li, Y; McCabe, CH; Michelson, AD; Murphy, SA; Qin, J; Wiviott, SD; Xenopoulos, NP	1
Ernest, CS; Farid, NA; Li, YG; Ni, L; Payne, CD; Salazar, DE; Small, DS; Winters, KJ; Wrishko, RE	1
Farid, NA; Jakubowski, JA; Kothare, P; Lachno, DR; Li, YG; Ni, L; Payne, CD; Salazar, DE; Small, DS; Thieu, VT; Winters, KJ; Yuen, E	1
del Río, A; Heras, M	1
Bal dit Sollier, C; Barthélémy, O; Beygui, F; Cohen, R; Collet, JP; Drouet, L; Henry, P; Lim, P; Luo, J; Marshall, D; Meuleman, C; Montalescot, G; Petitjean, H; Sideris, G	1
Jakubowski, JA; Li, YG; Luo, J; Payne, CD; Small, DS; Tomlin, ME; Winters, KJ	1
Jiang, X; Wong, PC	1
Cattaneo, M	2
Bhavaraju, K; Gartner, TK; Georgakis, A; Jin, J; Kunapuli, SP; Nurden, A; Nurden, P; Tomiyama, Y	1
Fox, SC; Glenn, JR; Heptinstall, S; Iyú, D; White, AE	1
Behr, T; Behr, W; Kuch, B; von Scheidt, W	1
Antman, EM; Braunwald, E; Costigan, TM; Frelinger, AL; Jakubowski, JA; McCabe, CH; Michelson, AD; Miller, DL; Neumann, FJ; Trenk, D; Wiviott, SD	1
Aradi, D; Atar, D; Kuliczkowski, W; Serebruany, VL	1
Castriota, F; Grzesk, E; Grzesk, G; Kozinski, M; Krzyzanowski, M; Kubica, A; Kubica, J; Navarese, EP; Siller-Matula, JM	1
Baeriswyl, G; Cook, S; Goy, JJ; Lehmann, S; Lehner, C; Oberhänsli, M; Puricel, S; Stauffer, JC; Togni, M	1
Alexopoulos, D; Damelou, A; Davlouros, P; Gkizas, V; Hahalis, G; Theodoropoulos, KC; Tsigkas, G; Xanthopoulou, I	1
Angiolillo, DJ; Bass, TA; Desai, B; Ferreiro, JL; Guzman, LA; Rollini, F; Seecheran, N; Tello-Montoliu, A; Tomasello, SD; Ueno, M	1
Choi, HC; Gu, N; Kawakatsu, E; Kelly, RP; Park, KW; Payne, C; Pinton, P; Small, DS; Yu, KS	1
Gremmel, T; Kopp, CW; Koppensteiner, R; Panzer, S; Seidinger, D; Steiner, S	1
Cui, Y; Xiang, Q; Zhao, N; Zhao, X	1
Angiolillo, DJ; Bass, TA; Darlington, A; Desai, B; Franchi, F; Guzman, LA; Muñiz-Lozano, A; Patel, R; Rollini, F; Tello-Montoliu, A; Thano, E; Wilson, RE	1
Jakubowski, JA; Mizuno, M; Ohno, K; Sugidachi, A; Tomizawa, A	1
Dhillon, K; Dovlatova, N; Fox, SC; Glenn, JR; Heptinstall, S; White, AE	1
Frelinger, AL; Gupta, N; Howard, J; Jakubowski, JA; Jurcevic, S; Lachno, DR; Mant, TG; Payne, CD; Winters, KJ; Zhou, C	1
Abendschein, D; Broekman, MJ; Chen, R; Drosopoulos, JH; Jeong, SS; Marcus, AJ; Moeckel, D; Nguyen, A; Robson, SC; Sun, X	1
Assinger, A; Kral, JB; Scharbert, G; Schrottmaier, WC; Weber, T; Wetzel, L	1
Fawcett, JP; Gu, J; Liu, M; Meng, X; Su, C; Wang, H; Xu, X; Yang, Y; Yang, Z; Zhao, X	1
An, N; Liu, C; Lu, Y; Wang, J; Zhang, Q; Zhao, L	1
Amorim, JA; Castela, AC; Machado, IF; Palmeira, CM; Rolo, AP; Sinclair, DA; Steegborn, C; Teodoro, JS	1

Reviews

8 review(s) available for adenosine diphosphate and thiophenes

Article	Year
Ticlopidine hydrochloride: relationship between dose, kinetics, plasma concentration and effect on platelet function. Thrombosis research. Supplement, 1983, Volume: 4 Topics: Adenosine Diphosphate; Animals; Blood Coagulation; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Fibrinolytic Agents; Humans; Kinetics; Platelet Aggregation; Rats; Thiophenes; Ticlopidine; Time Factors	1983
The mechanisms of action of ticlopidine. Thrombosis research. Supplement, 1983, Volume: 4 Topics: Adenosine Diphosphate; Animals; Fibrinolytic Agents; Humans; In Vitro Techniques; Malondialdehyde; Platelet Aggregation; Prostaglandins; Thiophenes; Ticlopidine; Time Factors	1983
Pharmacology of CS-747 (prasugrel, LY640315), a novel, potent antiplatelet agent with in vivo P2Y12 receptor antagonist activity. Seminars in thrombosis and hemostasis, 2005, Volume: 31, Issue:2 Topics: Adenosine Diphosphate; Adult; Animals; Aspirin; Biotransformation; Clinical Trials, Phase I as Topic; Clopidogrel; Collagen; Drug Evaluation, Preclinical; Drug Synergism; Fibrinolytic Agents; Hemostasis; Humans; Male; Membrane Proteins; Molecular Structure; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thiophenes; Thrombin; Thrombosis; Ticlopidine	2005
Prasugrel. Expert opinion on investigational drugs, 2006, Volume: 15, Issue:12 Topics: Adenosine Diphosphate; Animals; Aspirin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase III as Topic; Clopidogrel; Collagen; Coronary Disease; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Drugs, Investigational; Humans; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Pyridines; Rats; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine	2006
Greater inhibition of platelet aggregation and reduced response variability with prasugrel versus clopidogrel: an integrated analysis. Journal of cardiovascular pharmacology and therapeutics, 2007, Volume: 12, Issue:3 Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Bayes Theorem; Clinical Trials, Phase I as Topic; Clopidogrel; Databases, Factual; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Treatment Outcome	2007
Update on antiplatelet therapy in acute coronary syndromes: what do new drugs bring into clinical practice? American journal of cardiovascular drugs : drugs, devices, and other interventions, 2009, Volume: 9 Suppl 1 Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Clopidogrel; Humans; Lactones; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticagrelor; Ticlopidine	2009
The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects. Blood, 2011, Feb-17, Volume: 117, Issue:7 Topics: Adenosine; Adenosine Diphosphate; Animals; Blood Platelet Disorders; Blood Platelets; Clopidogrel; Female; Hemorrhage; Humans; Male; Mice; Mutation; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Thiophenes; Ticagrelor; Ticlopidine	2011
Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate. Thrombosis and haemostasis, 2011, Volume: 105 Suppl 1 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Clinical Trials, Phase III as Topic; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Thiophenes; Ticagrelor; Ticlopidine	2011

Trials

26 trial(s) available for adenosine diphosphate and thiophenes

Article	Year
Effects of ticlopidine, a new platelet aggregation inhibitor in man. Clinical pharmacology and therapeutics, 1975, Volume: 18, Issue:4 Topics: Adenosine Diphosphate; Adult; Aged; Clinical Trials as Topic; Collagen; Depression, Chemical; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Pyridines; Thiophenes; Time Factors	1975
Effects of ticlopidine of platelet function in men with stable angina pectoris. Thrombosis and haemostasis, 1985, Dec-17, Volume: 54, Issue:4 Topics: Adenosine Diphosphate; Adult; Aged; Angina Pectoris; Blood Platelets; Clinical Trials as Topic; Collagen; Double-Blind Method; Epinephrine; Epoprostenol; Humans; Male; Middle Aged; Platelet Aggregation; Thiophenes; Ticlopidine	1985
Effects of decompression on platelets and hemostasis in men and the influence of antiplatelet drugs (RA233 and VK744). Aerospace medicine, 1974, Volume: 45, Issue:3 Topics: Adenosine Diphosphate; Adult; Aspartate Aminotransferases; Atmosphere Exposure Chambers; Atmospheric Pressure; Blood Cell Count; Blood Platelets; Cholinesterases; Clinical Trials as Topic; Creatine Kinase; Decompression Sickness; Epinephrine; Ethanolamines; Hematopoiesis; Hemostasis; Humans; L-Lactate Dehydrogenase; Male; Morpholines; Piperidines; Platelet Adhesiveness; Pyrimidines; Thiophenes; Thrombin; Thrombocytopenia; Time Factors	1974
Ticlopidine activity on platelet function in patients with enhanced platelet aggregation. A short-term crossover study. Haemostasis, 1983, Volume: 13, Issue:5 Topics: Adenosine Diphosphate; Adult; Aged; beta-Thromboglobulin; Bleeding Time; Blood Platelets; Collagen; Epoprostenol; Humans; Male; Middle Aged; Platelet Aggregation; Prostaglandin D2; Prostaglandins D; Thiophenes; Thromboxane B2; Ticlopidine	1983
The influence of ticlopidine on the natural course of retinal vein occlusion. Agents and actions. Supplements, 1984, Volume: 15 Topics: Adenosine Diphosphate; Adult; Aged; Anticoagulants; Clinical Trials as Topic; Diabetes Mellitus; Female; Humans; Hyperlipidemias; Hypertension; Male; Middle Aged; Platelet Aggregation; Retinal Diseases; Retinal Vein; Risk; Thiophenes; Ticlopidine; Visual Acuity	1984
Ticlopidine in the secondary prevention of early diabetes-related microangiopathy: protocol of a multicenter therapeutic study (TIMAD study). Agents and actions. Supplements, 1984, Volume: 15 Topics: Adenosine Diphosphate; Adolescent; Adult; Aged; Anticoagulants; Brain Ischemia; Clinical Trials as Topic; Diabetic Angiopathies; Diabetic Neuropathies; Diabetic Retinopathy; Electrocardiography; Fluorescein Angiography; Follow-Up Studies; Humans; Middle Aged; Patient Compliance; Platelet Aggregation; Thiophenes; Ticlopidine	1984
Antiaggregatory, physiological and clinical effects of ticlopidine in subjects with peripheral atherosclerosis. Atherosclerosis, 1980, Volume: 36, Issue:4 Topics: Adenosine Diphosphate; Aged; Arachidonic Acids; Arteriosclerosis; Blood Coagulation; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Pyridines; Thiophenes; Ticlopidine	1980
The platelet inhibitory effects and pharmacokinetics of prasugrel after administration of loading and maintenance doses in healthy subjects. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:3 Topics: Adenosine Diphosphate; Adult; Bleeding Time; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes	2006
Platelet inhibitory activity and pharmacokinetics of prasugrel (CS-747) a novel thienopyridine P2Y12 inhibitor: a single ascending dose study in healthy humans. Platelets, 2006, Volume: 17, Issue:4 Topics: Adenosine Diphosphate; Administration, Oral; Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Time Factors	2006
Dose-dependent inhibition of human platelet aggregation by prasugrel and its interaction with aspirin in healthy subjects. Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:3 Topics: Adenosine Diphosphate; Adolescent; Adult; Aspirin; Bleeding Time; Clopidogrel; Collagen; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Middle Aged; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine	2007
Increased active metabolite formation explains the greater platelet inhibition with prasugrel compared to high-dose clopidogrel. Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:5 Topics: Adenosine Diphosphate; Adult; Area Under Curve; Blood Platelets; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine	2007
A comparison of the antiplatelet effects of prasugrel and high-dose clopidogrel as assessed by VASP-phosphorylation and light transmission aggregometry. Thrombosis and haemostasis, 2008, Volume: 99, Issue:1 Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flow Cytometry; Humans; Light; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results; Thiophenes; Ticlopidine; Time Factors	2008
Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel. Journal of clinical pharmacology, 2008, Volume: 48, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Adolescent; Adult; Aged; Area Under Curve; Biological Availability; Clopidogrel; Cross-Over Studies; Drug Interactions; Female; Humans; Lansoprazole; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Proton Pump Inhibitors; Thiophenes; Ticlopidine	2008
Switching directly to prasugrel from clopidogrel results in greater inhibition of platelet aggregation in aspirin-treated subjects. Platelets, 2008, Volume: 19, Issue:4 Topics: Adenosine Diphosphate; Adult; Aspirin; Clopidogrel; Drug-Related Side Effects and Adverse Reactions; Female; Hemorrhage; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine	2008
Pharmacodynamic assessment of platelet inhibition by prasugrel vs. clopidogrel in the TRITON-TIMI 38 trial. European heart journal, 2009, Volume: 30, Issue:14 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Thiophenes; Ticlopidine	2009
Effect of age on the pharmacokinetics and pharmacodynamics of prasugrel during multiple dosing: an open-label, single-sequence, clinical trial. Drugs & aging, 2009, Volume: 26, Issue:9 Topics: Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Aging; Aspirin; Bleeding Time; Body Mass Index; Confidence Intervals; Drug Therapy, Combination; Fasting; Female; Humans; Least-Squares Analysis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Statistics, Nonparametric; Tablets, Enteric-Coated; Thiophenes; Young Adult	2009
The pharmacokinetics and pharmacodynamics of prasugrel in healthy Chinese, Japanese, and Korean subjects compared with healthy Caucasian subjects. European journal of clinical pharmacology, 2010, Volume: 66, Issue:2 Topics: Adenosine Diphosphate; Adult; Aged; Asian People; Body Mass Index; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Prodrugs; Statistics as Topic; Thiophenes; White People; Young Adult	2010
Prasugrel compared with high-dose clopidogrel in acute coronary syndrome. The randomised, double-blind ACAPULCO study. Thrombosis and haemostasis, 2010, Volume: 103, Issue:1 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Aged, 80 and over; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Paris; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Thiophenes; Ticlopidine; Time Factors; Treatment Outcome	2010
Antagonism of P2Y₁₂ reduces physiological thromboxane levels. Platelets, 2010, Volume: 21, Issue:8 Topics: Adenosine Diphosphate; Adolescent; Adult; Animals; Blood Platelets; Clopidogrel; Female; Humans; Male; Mice; Mice, Knockout; Middle Aged; Pilot Projects; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thromboxanes; Ticlopidine; Young Adult	2010
Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. Thrombosis and haemostasis, 2011, Volume: 106, Issue:2 Topics: Adenosine Diphosphate; Aged; Clopidogrel; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine	2011
A randomized comparison of platelet reactivity in patients after treatment with various commercial clopidogrel preparations: the CLO-CLO trial. Archives of cardiovascular diseases, 2012, Volume: 105, Issue:11 Topics: Adenosine Diphosphate; Aged; Aged, 80 and over; Clopidogrel; Cross-Over Studies; Drugs, Generic; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Patient Selection; Percutaneous Coronary Intervention; Piperazines; Platelet Activation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Single-Blind Method; Stents; Therapeutic Equivalency; Thiophenes; Thrombosis; Ticlopidine; Treatment Outcome	2012
Pretreatment platelet reactivity contribution to residual, post-treatment platelet reactivity in prasugrel-treated and ticagrelor-treated patients. Journal of thrombosis and haemostasis : JTH, 2013, Volume: 11, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Humans; Myocardial Infarction; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticagrelor; Time Factors; Treatment Outcome	2013
Impact of prasugrel reload dosing regimens on high on-treatment platelet reactivity rates in patients on maintenance prasugrel therapy. JACC. Cardiovascular interventions, 2013, Volume: 6, Issue:2 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Biomarkers; Blood Platelets; Cell Adhesion Molecules; Chi-Square Distribution; Drug Administration Schedule; Drug Resistance; Humans; Microfilament Proteins; Percutaneous Coronary Intervention; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Time Factors; Treatment Outcome	2013
Pharmacokinetic and pharmacodynamic effects of prasugrel in healthy Korean males. Journal of cardiovascular pharmacology, 2013, Volume: 62, Issue:1 Topics: Adenosine Diphosphate; Adult; Area Under Curve; Asian People; Biotransformation; Blood Platelets; Chromatography, High Pressure Liquid; Humans; Male; Mass Spectrometry; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Receptors, Purinergic P2Y12; Thiophenes; Treatment Outcome; Young Adult	2013
A phase 1 study of prasugrel in patients with sickle cell disease: effects on biomarkers of platelet activation and coagulation. Thrombosis research, 2014, Volume: 133, Issue:2 Topics: Adenosine Diphosphate; Adult; Anemia, Sickle Cell; Biomarkers; Blood Coagulation; Blood Platelets; Female; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Young Adult	2014
Comparison of patient intake of ticagrelor, prasugrel, or clopidogrel on restoring platelet function by donor platelets. Transfusion, 2015, Volume: 55, Issue:6 Topics: Adenosine; Adenosine Diphosphate; Aged; Blood Platelets; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Flow Cytometry; Half-Life; Humans; Male; Middle Aged; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Transfusion; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Thiophenes; Ticagrelor; Ticlopidine	2015

Other Studies

59 other study(ies) available for adenosine diphosphate and thiophenes

Article	Year
Effect of an inhibitor of platelets aggregation, ticlopidine of energy transduction of rat liver mitochondria in vitro. Biochemical pharmacology, 1978, Volume: 27, Issue:17 Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Energy Transfer; In Vitro Techniques; Male; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Platelet Aggregation; Pyridines; Rats; Thiophenes	1978
Effects of ticlopidine on platelet prostaglandin metabolism. Possible consequences for prostacyclin production. Prostaglandins and medicine, 1979, Volume: 2, Issue:6 Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acids; Blood Platelets; Epoprostenol; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Prostaglandins E; Pyridines; Thiophenes; Ticlopidine	1979
Inhibition of platelet aggregation by a new agent, Ticlopidine. Thrombosis and haemostasis, 1979, Feb-15, Volume: 40, Issue:3 Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Blood Platelets; Cell Survival; Collagen; Male; Platelet Aggregation; Prostaglandins G; Pyridines; Rats; Thiophenes; Thrombin; Thromboxane A2	1979
Compared effects of three dose-levels of ticlopidine on platelet function in normal subjects. Thrombosis research, 1979, Volume: 14, Issue:1 Topics: Adenosine Diphosphate; Adult; Blood Coagulation Tests; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Platelet Adhesiveness; Platelet Aggregation; Pyridines; Serotonin; Thiophenes	1979
The effect of ticlopidine on platelet function in normal volunteers and in patients with platelet hyperaggregability in vitro. Thrombosis research, 1979, Volume: 16, Issue:5-6 Topics: Adenosine Diphosphate; Adult; Aged; Bleeding Time; Blood Platelets; Collagen; Epinephrine; Female; Hemostasis; Humans; Male; Middle Aged; Platelet Aggregation; Pyridines; Serotonin; Thiophenes	1979
Ticlopidine - an antiplatelet drug: effects in human volunteers. Thrombosis research, 1978, Volume: 13, Issue:2 Topics: Adenosine Diphosphate; Anticoagulants; Blood Coagulation Tests; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Epinephrine; Humans; Malondialdehyde; Platelet Aggregation; Prostaglandins; Pyridines; Serotonin; Thiophenes; Thrombin	1978
Effects of suprofen, an inhibitor of prostaglandin biosynthesis, on platelet function, plasma coagulation and fibrinolysis. I. In vitro experiments. Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 216, Issue:2 Topics: Adenosine Diphosphate; Arachidonic Acids; Blood Coagulation; Blood Platelets; Collagen; Epinephrine; Fibrinolysis; Humans; In Vitro Techniques; Male; Phenylpropionates; Platelet Aggregation; Platelet Factor 4; Prostaglandin Antagonists; Serotonin; Thiophenes; Thrombin; Trypsin Inhibitors	1975
Effects of suprofen, an inhibitor of prostaglandin biosynthesis, on platelet function, plasma coagulation and fibrinolysis II. In vivo experiments. Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 217, Issue:1 Topics: Adenosine Diphosphate; Animals; Aspirin; Blood Coagulation; Blood Platelets; Collagen; Dogs; Fibrinolysis; Guinea Pigs; Hemostasis; Male; Phenylbutazone; Phenylpropionates; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin Antagonists; Pyrimidines; Rats; Thiophenes; Time Factors; Warfarin	1975
Mechanism of interaction of ticlopidine and its analogues with the energy-conserving mechanism in mitochondria. Biochemical pharmacology, 1986, Jun-01, Volume: 35, Issue:11 Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Animals; Anticoagulants; Biological Transport; Energy Metabolism; Kinetics; Male; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; Oxygen Consumption; Platelet Aggregation; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiophenes; Ticlopidine	1986
Platelet-dependent granulocyte activation in vitro: effect of ticlopidine. International journal of tissue reactions, 1985, Volume: 7, Issue:5 Topics: Adenosine Diphosphate; Blood Platelets; Cytochalasin B; Glucuronidase; Humans; In Vitro Techniques; Neutrophils; Platelet Aggregation; Superoxides; Thiophenes; Ticlopidine	1985
Inhibitory effects of three new synthetic compounds on human platelet aggregation. Thrombosis research, 1986, Nov-15, Volume: 44, Issue:4 Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Structure-Activity Relationship; Thiophenes; Thrombin	1986
Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin in the arteriole of the hamster cheek pouch. Arzneimittel-Forschung, 1986, Volume: 36, Issue:4 Topics: Adenosine Diphosphate; Animals; Arteries; Cheek; Cricetinae; Dipyridamole; Epoprostenol; Fibrinolytic Agents; Male; Mesocricetus; Regional Blood Flow; Thiophenes; Ticlopidine; Time Factors	1986
Ticlopidine and platelet function. Thrombosis and haemostasis, 1986, Jun-30, Volume: 55, Issue:3 Topics: Adenosine Diphosphate; Drug Synergism; Epoprostenol; Humans; Platelet Aggregation; Thiophenes; Ticlopidine	1986
Bicyclic thiophenic derivatives as platelet aggregation inhibitors. Il Farmaco; edizione scientifica, 1986, Volume: 41, Issue:6 Topics: Adenosine Diphosphate; Adult; Collagen; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Thiophenes	1986
Platelet activation induced by a human neuroblastoma tumor cell line is reduced by prior administration of ticlopidine. Thrombosis and haemostasis, 1986, Jun-30, Volume: 55, Issue:3 Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Line; Female; Humans; In Vitro Techniques; Male; Middle Aged; Neuroblastoma; Perfusion; Platelet Aggregation; Thiophenes; Thrombosis; Ticlopidine	1986
Effect of ticlopidine on neutrophil chemotaxis in rats. Haemostasis, 1985, Volume: 15, Issue:2 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Cell Membrane; Chemotaxis, Leukocyte; Depression, Chemical; Male; Neutrophils; Platelet Aggregation; Rats; Thiophenes; Ticlopidine; Zymosan	1985
Isolation and characterization of Tetrahymena pyriformis GL mitochondria. Comparative biochemistry and physiology. B, Comparative biochemistry, 1972, Jan-15, Volume: 41, Issue:1 Topics: Adenosine Diphosphate; Amobarbital; Animals; Antimycin A; Butanones; Cell Fractionation; Centrifugation; Chlorine; Cyanides; Depression, Chemical; Dinitrophenols; Electron Transport; Fluorine; Isocitrates; Methods; Mitochondria; NAD; Oligomycins; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Pentachlorophenol; Phenols; Phosphates; Phosphorus Isotopes; Potassium; Rotenone; Species Specificity; Structure-Activity Relationship; Succinates; Tetrahymena pyriformis; Thiophenes	1972
The effect of pyrimidine compounds on the potentiation of adenosine inhibition of aggregation, on adenosine phosphorylation and phosphodiesterase activity of blood platelets. British journal of haematology, 1973, Volume: 24, Issue:4 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Carbon Isotopes; Cyclic AMP; Dipyridamole; Ethanolamines; Ethylamines; Humans; In Vitro Techniques; Morpholines; Phosphoric Diester Hydrolases; Piperidines; Platelet Adhesiveness; Pyrimidines; Thiophenes	1973
Assessment of antithrombotic agents: effects of dipyridamole analogues on platelet behaviour. Cardiovascular research, 1972, Volume: 6, Issue:6 Topics: Adenosine Diphosphate; Animals; Blood Coagulation; Blood Platelets; Cerebral Arteries; Dipyridamole; Electrophoresis; Ethylamines; Morpholines; Norepinephrine; Piperazines; Platelet Adhesiveness; Pyrimidines; Rabbits; Structure-Activity Relationship; Thiophenes; Thrombosis	1972
Effect in vitro on platelet function of two compounds developed from the pyrimido-pyrimidines. Journal of clinical pathology, 1972, Volume: 25, Issue:5 Topics: Adenosine Diphosphate; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Cell Aggregation; Ethylamines; Humans; In Vitro Techniques; Kaolin; Morpholines; Phospholipids; Piperazines; Platelet Adhesiveness; Pyrimidines; Thiophenes	1972
In vivo effect of ticlopidine on fibrinogen-platelet cofactor activity and binding of fibrinogen to platelets. Agents and actions. Supplements, 1984, Volume: 15 Topics: Adenosine Diphosphate; Anticoagulants; Blood Platelets; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Cell Surface; Thiophenes; Ticlopidine	1984
Inhibition of thrombocytopenic episodes caused by the Arthus reaction, the sub-lethal Forssman reaction and ADP. Artery, 1980, Volume: 8, Issue:5 Topics: Adenosine Diphosphate; Animals; Antibodies; Arthus Reaction; Aspirin; Dipyridamole; Forssman Antigen; Guinea Pigs; Humans; Nervous System Diseases; Platelet Count; Pyridines; Sulfides; Sulfinpyrazone; Thiophenes; Thrombocytopenia; Ticlopidine	1980
In vivo study of platelet aggregation in rats. Journal of pharmacological methods, 1984, Volume: 12, Issue:2 Topics: Adenosine Diphosphate; Animals; Aspirin; Collagen; Diet; Dose-Response Relationship, Drug; Male; Methods; Platelet Aggregation; Platelet Count; Rats; Rats, Inbred Strains; Thiophenes; Thrombosis; Ticlopidine	1984
Ex vivo and in vivo evaluation of drugs that inhibit platelet function. Annals of the New York Academy of Sciences, 1983, Volume: 416 Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Blood Platelets; Collagen; Dipyridamole; Imidazoles; Male; Papio; Platelet Aggregation; Sulfinpyrazone; Thiazines; Thiophenes; Ticlopidine	1983
Comparative study of platelet aggregation measured with 3 different methods (photometric and impedance) in ticlopidine treated patients. Agents and actions. Supplements, 1984, Volume: 15 Topics: Adenosine Diphosphate; Adult; Aged; Anticoagulants; Female; Humans; In Vitro Techniques; Male; Methods; Middle Aged; Platelet Aggregation; Spectrophotometry; Thiophenes; Ticlopidine	1984
Antiplatelet drugs and thrombosis prevention: ticlopidine in perspective. Agents and actions, 1984, Volume: 14, Issue:1 Topics: Adenosine Diphosphate; Aspirin; Bleeding Time; Blood Platelets; Fibrinolytic Agents; Humans; Thiophenes; Thrombosis; Ticlopidine	1984
Effects of antiplatelet agents on pulmonary metastases. Gan, 1984, Volume: 75, Issue:3 Topics: Adenosine Diphosphate; Animals; Depression, Chemical; Diltiazem; Dipyridamole; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Platelet Aggregation; Thiophenes; Ticlopidine; Trapidil	1984
Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets. Thrombosis research, 1984, Jun-15, Volume: 34, Issue:6 Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Humans; Platelet Activating Factor; Platelet Aggregation; Rabbits; Thiophenes; Ticlopidine	1984
Platelet aggregation measured in rabbit whole blood: in vitro study of 3 aggregating agents and ex vivo inhibition by aspirin and ticlopidine. Archives internationales de pharmacodynamie et de therapie, 1982, Volume: 259, Issue:2 Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Collagen; In Vitro Techniques; Platelet Aggregation; Platelet Count; Rabbits; Thiophenes; Ticlopidine	1982
Comparison between the antiaggregating effect of ticlopidine in whole blood, platelet-rich plasma and washed platelets of the rat. Thrombosis research, 1982, Apr-01, Volume: 26, Issue:1 Topics: Adenosine Diphosphate; Animals; Dinoprostone; Epoprostenol; In Vitro Techniques; Male; Plasma; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Thiophenes; Ticlopidine	1982
A possible method to control prolongations of bleeding time under antiplatelet therapy with ticlopidine. Thrombosis and haemostasis, 1982, Aug-24, Volume: 48, Issue:1 Topics: Adenosine Diphosphate; Administration, Oral; Adult; Bleeding Time; Female; Humans; Hydrocortisone; Injections, Intravenous; Male; Platelet Aggregation; Prednisolone; Thiophenes; Ticlopidine; Vasoconstrictor Agents	1982
Modulation of the inhibitory action of prostaglandin E1 on platelet aggregation in rats: a study with ticlopidine, aspirin, dipyridamole and sulfinpyrazone. Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6 Topics: Adenosine Diphosphate; Alprostadil; Animals; Aspirin; Dipyridamole; Male; Phosphorylation; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfinpyrazone; Thiophenes; Ticlopidine	1982
Effect of ticlopidine on human platelet responsiveness ex vivo: comparison with aspirin. Thrombosis research, 1980, Jun-15, Volume: 18, Issue:6 Topics: Adenosine Diphosphate; Adult; Aspirin; Collagen; Dose-Response Relationship, Drug; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Pyridines; Serotonin; Thiophenes; Ticlopidine	1980
An aldose reductase inhibitor, TAT, reduces ADP-induced platelet hyperaggregation in streptozotocin-induced diabetic rats with neuropathy. The Journal of laboratory and clinical medicine, 1995, Volume: 126, Issue:6 Topics: Adenosine Diphosphate; Aldehyde Reductase; Ampholyte Mixtures; Animals; Blood Glucose; Blood Platelets; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Male; Neural Conduction; Platelet Aggregation; Polymers; Rats; Rats, Wistar; Sciatic Nerve; Streptozocin; Tetrazoles; Thiophenes	1995
Pharmacokinetic and pharmacodynamic profiles of CS-518, a selective, long-lasting thromboxane synthase inhibitor, after single and multiple oral administration to healthy volunteers. Journal of clinical pharmacology, 1994, Volume: 34, Issue:1 Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Administration, Oral; Adult; Drug Administration Schedule; Eating; Half-Life; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thiophenes; Thromboxane B2; Thromboxane-A Synthase	1994
An aldose reductase inhibitor, TAT, prevents electroretinographic abnormalities and ADP-induced hyperaggregability in streptozotocin-induced diabetic rats. European journal of clinical investigation, 1995, Volume: 25, Issue:12 Topics: Adenosine Diphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Enzyme Inhibitors; Fructose; Glucose; Male; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Retina; Sorbitol; Tetrazoles; Thiophenes	1995
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. British journal of pharmacology, 2000, Volume: 129, Issue:7 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium	2000
Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747. British journal of pharmacology, 2001, Volume: 132, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cyclic AMP; Cyclopropanes; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; In Vitro Techniques; Male; Membrane Proteins; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes	2001
The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:7 Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Clopidogrel; Cyclic AMP; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine	2007
The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin. Thrombosis and haemostasis, 2007, Volume: 98, Issue:1 Topics: Adenosine Diphosphate; Adult; Aspirin; Biomarkers; Blood Cells; Calcium; Cells, Cultured; Female; Humans; Inflammation; Kinetics; Male; Middle Aged; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Thrombosis; Up-Regulation	2007
The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities. Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:2 Topics: Adenosine Diphosphate; Annexin A5; Biotransformation; Blood Coagulation Factors; Blood Platelets; Clot Retraction; Collagen; Humans; Monocytes; Phosphatidylserines; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Prodrugs; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Thrombelastography; Thrombin; Thromboplastin	2008
The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function. Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:7 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Interactions; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine	2008
Multiple electrode aggregometry and P2Y(12) antagonists. Thrombosis and haemostasis, 2008, Volume: 99, Issue:6 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Clopidogrel; Dose-Response Relationship, Drug; Electrodes; Equipment Design; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine	2008
Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability. Thrombosis and haemostasis, 2009, Volume: 101, Issue:1 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine	2009
A comparison of the VerifyNow P2Y12 point-of-care device and light transmission aggregometry to monitor platelet function with prasugrel and clopidogrel: an integrated analysis. Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:1 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Adult; Aged; Clinical Trials as Topic; Clopidogrel; Coronary Artery Disease; Databases, Factual; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Point-of-Care Systems; Prasugrel Hydrochloride; Thiophenes; Ticlopidine	2010
Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. Thrombosis and haemostasis, 2010, Volume: 104, Issue:2 Topics: Adenosine Diphosphate; Anticoagulants; Arginine; Azetidines; Benzimidazoles; Collagen; Dabigatran; Dose-Response Relationship, Drug; Factor VIIa; Factor Xa; Factor Xa Inhibitors; Factor XIa; Humans; Morpholines; Pipecolic Acids; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Sulfonamides; Thiophenes; Thrombin; Thromboplastin; Time Factors	2010
Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist. Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cell Adhesion Molecules; Erythrocytes; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Receptors, Thrombin; Thiophenes; Ticagrelor	2011
Optimizing of thienopyridine therapy by multiple electrode platelet aggregometry in clopidogrel low responders undergoing PCI. Clinical research in cardiology : official journal of the German Cardiac Society, 2011, Volume: 100, Issue:10 Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Cardiovascular Diseases; Cerebrovascular Disorders; Cilostazol; Clopidogrel; Drug Monitoring; Drug Resistance; Drug Substitution; Electrodes; Female; Germany; Humans; Logistic Models; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Predictive Value of Tests; Prospective Studies; Risk Assessment; Risk Factors; Stents; Tetrazoles; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Treatment Outcome	2011
Inter-patient variability and impact of proton pump inhibitors on platelet reactivity after prasugrel. Thrombosis and haemostasis, 2012, Volume: 107, Issue:2 Topics: Acute Coronary Syndrome; Adenosine Diphosphate; Aged; Clinical Protocols; Female; Humans; Male; Middle Aged; Observer Variation; Piperazines; Platelet Aggregation; Platelet Function Tests; Prasugrel Hydrochloride; Prevalence; Prospective Studies; Proton Pump Inhibitors; Thiophenes	2012
Ticagrelor, but not clopidogrel and prasugrel, prevents ADP-induced vascular smooth muscle cell contraction: a placebo-controlled study in rats. Thrombosis research, 2012, Volume: 130, Issue:1 Topics: Adenosine; Adenosine Diphosphate; Animals; Arteries; Clopidogrel; Muscle Contraction; Myocytes, Smooth Muscle; Piperazines; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Rats; Rats, Wistar; Thiophenes; Ticagrelor; Ticlopidine	2012
Preserved thrombin-inducible platelet activation in thienopyridine-treated patients. European journal of clinical investigation, 2013, Volume: 43, Issue:7 Topics: Adenosine Diphosphate; Aged; Angioplasty; Aspirin; Blood Platelets; Cardiovascular Diseases; Clopidogrel; Female; Humans; Integrin beta3; Male; Middle Aged; P-Selectin; Peptide Fragments; Piperazines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoprotein IIb; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Stents; Thiophenes; Thrombin; Ticlopidine	2013
Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics. Pharmacogenomics, 2013, Volume: 14, Issue:10 Topics: Adenosine Diphosphate; Adult; Blood Platelets; Female; Humans; Male; Pharmacogenetics; Piperazines; Platelet Aggregation; Polymorphism, Single Nucleotide; Prasugrel Hydrochloride; Receptors, Cell Surface; Thiophenes	2013
Impact of aspirin dose on adenosine diphosphate-mediated platelet activities. Results of an in vitro pilot investigation. Thrombosis and haemostasis, 2013, Volume: 110, Issue:4 Topics: Adenosine Diphosphate; Aged; Aspirin; Cell Adhesion Molecules; Coronary Artery Disease; Drug Dosage Calculations; Female; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Pilot Projects; Piperazines; Platelet Activation; Platelet Function Tests; Prasugrel Hydrochloride; Prospective Studies; Purinergic P2Y Receptor Antagonists; Thiophenes	2013
Comparison of antiplatelet effects of prasugrel and ticagrelor in cynomolgus monkeys by an ELISA-based VASP phosphorylation assay and platelet aggregation. Thrombosis and haemostasis, 2013, Volume: 110, Issue:4 Topics: Adenosine; Adenosine Diphosphate; Administration, Oral; Adult; Animals; Cell Adhesion Molecules; Clinical Protocols; Enzyme-Linked Immunosorbent Assay; Humans; Macaca fascicularis; Male; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Thiophenes; Ticagrelor; Young Adult	2013
'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists. Thrombosis and haemostasis, 2014, Mar-03, Volume: 111, Issue:3 Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Biomarkers, Pharmacological; Blood Platelets; Bucladesine; Cell Adhesion Molecules; Cells, Cultured; Clopidogrel; Cyclic AMP; Humans; Iloprost; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Sensitivity and Specificity; Thiophenes; Thrombophilia; Ticlopidine	2014
Optimizing human apyrase to treat arterial thrombosis and limit reperfusion injury without increasing bleeding risk. Science translational medicine, 2014, Aug-06, Volume: 6, Issue:248 Topics: Adenosine Diphosphate; Animals; Apyrase; Clopidogrel; Coronary Circulation; Dogs; Fibrinolysis; Hemorrhage; Humans; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Piperazines; Platelet Aggregation; Prasugrel Hydrochloride; Risk Factors; Thiophenes; Thrombosis; Ticlopidine; Time Factors; Tissue Plasminogen Activator; Treatment Outcome; Vascular Patency	2014
Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration. Molecules (Basel, Switzerland), 2016, May-30, Volume: 21, Issue:6 Topics: Adenosine Diphosphate; Animals; Clopidogrel; Hydrolysis; Male; Metabolic Networks and Pathways; Models, Molecular; Molecular Conformation; Phenylacetates; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Thiophenes; Ticlopidine	2016
A new water-soluble polythiophene derivative as a probe for real-time monitoring adenosine 5'-triphosphatase activity in lysosome of living cells. Talanta, 2018, May-15, Volume: 182 Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Binding, Competitive; Biological Transport; Cell Line; Coordination Complexes; Fibroblasts; Hydrolysis; Kinetics; Lysosomes; Mice; Molecular Probes; Permeability; Polymers; Solubility; Spectrometry, Fluorescence; Thiophenes; Water; Zinc	2018
The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function. International journal of molecular sciences, 2020, Jul-11, Volume: 21, Issue:14 Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Constriction; Disease Models, Animal; Gene Expression Regulation; Hepatic Artery; Hormesis; Liver Failure; Male; Membrane Potential, Mitochondrial; Mitochondria, Liver; Oxygen Consumption; Phosphorylation; Portal Vein; Premedication; Pyrimidines; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Solubility; Thiophenes	2020