Page last updated: 2024-08-17

adenosine diphosphate and methylthio-adp

adenosine diphosphate has been researched along with methylthio-adp in 131 studies

Research

Studies (131)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (4.58)	18.7374
1990's	22 (16.79)	18.2507
2000's	55 (41.98)	29.6817
2010's	42 (32.06)	24.3611
2020's	6 (4.58)	2.80

Authors

Authors	Studies
Abo, M; Hai, TT; Hampton, A	1
Boyer, JL; Brizzolara, AL; Burnstock, G; Fischer, B; Harden, TK; Hoyle, CH; Jacobson, KA; Knight, GE; Ziganshin, AU; Zimmet, J	1
Harden, TK; Schachter, JB	1
Jacobson, KA; Jarvis, MF; Williams, M	1
Boyer, JL; Corbitt, J; Harden, TK; Jacobson, KA; Ji, XD; Kim, HS; Lacy, J; Ravi, G; Waldo, GL	1
Boeynaems, JM; Communi, D; Gonzalez, NS; Labouret, C; Le Poul, E; Marteau, F; Savi, P	1
Herbert, JM; Savi, P	2
Camden, J; Eliahu, SE; Fischer, B; Gélinas, S; Lecka, J; Sévigny, J; Weisman, GA	1
Barr, HM; Camden, J; Eliahu, S; Fischer, B; Weisman, GA	1
Barr, HM; Camden, J; Fischer, B; Shai, E; Varon, D; Weisman, GA; Yelovitch, S	1
Azran, S; Danino, O; Fischer, B; Förster, D; Nadel, Y; Reiser, G	1
Azran, S; Danino, O; Dixit, M; Fischer, B; Förster, D; Kenigsberg, S; Major, DT; Reiser, G; Singh, V	1
Cazenave, JP; Gachet, C; Hilf, G; Jakobs, KH; Ohlmann, P; Wieland, T	1
Macfarlane, DE	1
Colman, RF; Colman, RW; Freedman, MD; Grana, G; Hu, CJ; Mills, DC; Minniti, C; Puri, R	1
Colman, RF; Colman, RW; Figures, WR; Mills, DC; Scearce, LM; Stewart, GJ	1
Colman, RF; Colman, RW; Figures, WR; Mills, DC; Morinelli, TA; Niewiarowski, S	1
Macfarlane, DE; Mills, DC; Srivastava, PC	1
Brammer, JP; Maguire, MH	1
Cusack, NJ; Hourani, SM	1
Balcar, VJ; Bennett, MR; Killinger, S; Li, Y	1
Bihour, C; Heilmann, E; Herbert, JM; Maffrand, JP; Nurden, A; Nurden, P; Savi, P	1
Herbert, JM; Savi, P; Troussard, A	1
Aït-Chek, L; Bernat, A; Dumas, A; Herbert, JM; Savi, P	1
Herbert, JM; Laplace, MC; Maffrand, JP; Savi, P	1
Cassel, D; Cattaneo, M; Cazenave, JP; Chevalier, J; Gachet, C; Hechler, B; Lecchi, A; Mannucci, PM; Ohlmann, P	1
Barnard, EA; Burnstock, G; King, BF; Simon, J; Webb, TE	1
Artçanuthurry, V; Bornia, J; Grelac, F; Herbert, JM; Levy-Toledano, S; Maclouf, J; Savi, P	1
Cattaneo, M; Cazenave, JP; Gachet, C; Lombardi, R; Mannucci, PM; Ohlmann, P; Zighetti, ML	1
Harden, TK; Nicholas, RA; Schachter, JB; Sromek, SM	1
Ashby, B; Dangelmaier, C; Daniel, JL; Jin, J; Kunapuli, SP; Smith, JB	1
Duchêne, AD; Takeda, K	1
Boyer, JL; Harden, TK; Nicholas, RA; Palmer, RK; Schachter, JB	1
Martinson, EA; Marx-Grunwitz, A; Presek, P; Scheible, S	1
Breittmayer, JP; Frelin, C; Gachet, C; Hechler, B; Vigne, P	1
Hourani, SM; Park, HS	1
Ias'ko, MV; Skoblov, IuS; Skoblov, MIu	1
Asai, F; Inoue, T; Koike, H; Ogawa, T; Sugidachi, A	1
Fam, SR; Gallagher, CJ; Salter, MW	1
Järv, J; Sak, K	1
Dixon, CJ	1
Enkvist, E; Järv, J; Kelve, M; Raidaru, G; Sak, K; Subbi, J; Uri, A	1
Järv, J; Raidaru, G; Sak, K; Webb, TE	1
Asai, F; Iwamura, R; Koike, H; Ogawa, T; Otsuguro, K; Sugidachi, A; Yoneda, K	1
Barnard, EA; Järv, J; Sak, K	1
Barnard, EA; Cousens, DJ; Humphrey, PP; Lundahl, TS; Sellers, LA; Simon, J	1
Maayani, S; Martinelli, G; Martinez, R; Schwarz, T; Shore-Lesserson, L; Tagliente, TM	1
Arnett, TR; Burnstock, G; Hoebertz, A; Meghji, S	1
Claes, P; Grobben, B; Roymans, D; Slegers, H; Van Kolen, K	1
Bagorda, A; Casavola, V; Di Sole, F; Favia, M; Guerra, L; Helmle-Kolb, C; Jacobson, KA; Reshkin, SJ	1
Chambers, JK; Emson, PC; Moore, DJ; Murdock, PR	1
Edvinsson, L; Erlinge, D; Hou, M; Malmsjö, M; Pendergast, W	1
Bryckaert, M; Contreres, JO; Dupuy, E; Habib, A; Herbert, JM; Job, B; Levy-Toledano, S; Rosa, JP; Savi, P; Simoneau, G	1
Fam, SR; Gallagher, CJ; Kalia, LV; Salter, MW	1
Barnard, EA; Cheng, AW; Choi, RC; Ling, KK; Simon, J; Siow, NL; Tsim, KW; Tung, EK	1
Allen, DG; Barden, JA; Huang, W; Jiang, L; Ju, YK	1
Herbert, JM; Pacaud, P; Payrastre, B; Plantavid, M; Sauzeau, V; Savi, P; Soulet, C	1
Slegers, H; Van Kolen, K	1
Choi, RC; Jiang, JX; Lee, HH; Massoulié, J; Siow, NL; Ting, AK; Tsim, KW	1
Ding, Z; Jin, J; Kim, S; Kunapuli, SP; Murugappan, S; Shankar, H; Wickman, K	1
Bagorda, A; Calamita, G; Casavola, V; Fanelli, T; Favia, M; Guerra, L; Jacobson, KA; Reshkin, SJ; Svetlo, M	1
Bandivadekar, KR; Ding, Z; Jin, J; Kunapuli, SP; Tuluc, F; Zhang, L	1
Erlinge, D; Götberg, M; Olivecrona, G; Olsson, ML; Wang, L; Winzell, MS	1
Kucher, BM; Neary, JT	1
Konishi, S; Murakoshi, T; Saitow, F; Suzuki, H	1
Giron, R; Mizumura, K; Nakamura, R; Sato, J; Yajima, H	1
Gerevich, Z; Illes, P; Müller, C	1
Burnstock, G; Cowen, T; Knight, GE; Wallace, A	1
Baker, OJ; Camden, JM; Erb, L; Ratchford, AM; Seye, CI; Weisman, GA	1
Burnstock, G; Chiaravalli, AM; Frigo, G; Giaroni, C; Knight, GE; Lecchini, S; Zanetti, E	1
Inoue, K; Koizumi, S; Nagao, T; Ohno, Y; Shinozaki, Y	1
Erlinge, D; Götberg, M; Harnek, J; Jacobson, KA; Jern, S; Olivecrona, GK	1
Vadakkan, KI; Wu, LJ; Zhuo, M	1
Boarder, MR; Dixon, CJ; Hall, JF; Luo, Y; White, PJ	1
Calleri, E; Frazier, CR; Massolini, G; Moaddel, R; Wainer, IW	1
Miras-Portugal, MT; Ortega, F; Pérez-Sen, R	1
DiCorleto, PE; Shen, J	1
Besada, P; Gachet, C; Gao, ZG; Hechler, B; Jacobson, KA	1
Losavio, A; Muchnik, S; Veggetti, M	1
Audinat, E; Avignone, E; Levavasseur, F; Rassendren, F; Ulmann, L	1
Di Pasquale, F; Hoffmann, K; Sixel, U; von Kügelgen, I	1
Daniel, JL; Jin, J; Kim, S; Kunapuli, SP; Mao, Y; Thomas, D	1
Crain, EJ; Hua, J; Rehfuss, R; Schumacher, WA; Watson, CA; Wong, PC	1
Fraga, S; Gonçalves, J; Queiroz, G; Quintas, C	2
Gomes, DA; Song, Z; Stevens, W	1
Baqi, Y; Glänzel, M; Hoffmann, K; Morena, MS; Müller, CE; von Kügelgen, I	1
Carneiro, FS; Giachini, FR; Inscho, EW; Lima, VV; Osmond, DA; Tostes, RC; Webb, RC; Zhang, S	1
Beckerman, J; Myers, A; Vicini, S; Young, JP	1
Antel, JP; Ase, AR; Lambert, C; Séguéla, P	1
Cuadrado, A; Espada, S; Miras-Portugal, MT; Molina-Jijón, E; Ortega, F; Pedraza-Chaverri, J; Pérez-Sen, R; Rojo, AI	1
Amisten, S; Erlinge, D; Lundquist, I; Meidute-Abaraviciene, S; Olde, B; Salehi, A; Tan, C	1
Bal Dit Sollier, C; Berge, N; Boval, B; Drouet, L; Dubar, M	1
Ajmone-Cat, MA; De Nuccio, C; De Simone, R; Minghetti, L; Niturad, CE; Visentin, S	1
Geddawy, A; Imamura, T; Okamura, T; Shimosato, T; Tawa, M	1
Böhm, A; Driessen, J; Ermler, S; Fischer, JW; Jakubowski, JA; Rauch, BH; Rosenkranz, AC; Schrör, K; Sugidachi, A	1
Grass, EH; Holstein, DM; Keller, C; Lechleiter, JD; Prajapati, SI; Walter, CA; Watts, LT; Zheng, W	1
Brasseur, D; Bremond, N; Delesque Touchard, N; Hurbin, F; Lavisse, M; Rouchon, MC; Roy, S; Savi, P; Schofield, J; Sultan, E; Tuffal, G	1
Jantaratnotai, N; McLarnon, JG	1
Boehm, S; Chandaka, GK; Drobny, H; Salzer, I; Schicker, KW	1
Kim, S; Kunapuli, SP	1
Harada, K; Matsumoto, Y; Umemura, K	1
Delicado, EG; Ortega, F; Pérez-Sen, R; Teresa Miras-Portugal, M	1
Bender, SB; Berwick, ZC; Laughlin, MH; Tune, JD	1
Coppi, E; Gibb, AJ; Pedata, F	1
Inoue, K; Kohsaka, S; Nakamura, Y; Ohsawa, K; Sanagi, T; Suzuki, E	1
Ishida, K; Kamata, K; Kobayashi, T; Matsumoto, T; Taguchi, K	1
Cousins, DJ; Foster, HR; Fuerst, E; Lee, TH; Woszczek, G	1
Cipolla, L; Guidetti, G; Jin, J; Kim, S; Kunapuli, SP; Okigaki, M; Torti, M	1
Bhavanasi, D; Dangelmaier, C; Goldfinger, LE; Kim, S; Kunapuli, SP; Meng, S; Wang, H	1
Haas, M; Reiser, G; Shaaban, A	1
Giachini, FR; Inscho, EW; Leite, R; Lima, VV; Osmond, DA; Tostes, RC; Webb, RC	1
Cherezov, V; Gao, ZG; Han, GW; Jacobson, KA; Jiang, H; Katritch, V; Li, T; Ma, L; Müller, CE; Paoletta, S; Stevens, RC; Wu, B; Yang, H; Zhang, D; Zhang, J; Zhang, K; Zhang, W; Zhao, Q	1
Delicado, EG; Huerta-Cepas, J; Miras-Portugal, MT; Morente, V; Ortega, F; Pérez-Sen, R	1
Boldron, C; Bonnet-Lignon, S; Bono, F; Delesque-Touchard, N; Herbert, JM; Lassalle, G; Millet, L; Pflieger, AM; Salel, V; Savi, P	1
Kobayashi, K; Noguchi, K; Sakagami, M; Tatsumi, E; Yagi, H; Yamanaka, H	1
Baqi, Y; Hoffmann, K; Lutz, DA; Müller, CE; Straßburger, J; von Kügelgen, I	1
Hu, J; Jiang, M; Liao, L; Liu, X; Luo, J; Wang, W; Xiang, F	1
Eilers, J; Kraft, R; Michaelis, M; Nieswandt, B; Stegner, D	1
Almo, SC; Burgos, ES; Cameron, SA; Gulab, SA; Schramm, VL; Thomas, K	1
Cherezov, V; Crane, S; Gao, ZG; Han, GW; Jacobson, KA; Jiang, H; Katritch, V; Kiselev, E; Liu, H; Ma, L; Paoletta, S; Stevens, RC; Wang, J; Wu, B; Yi, C; Zhang, D; Zhang, K; Zhang, W; Zhao, Q	1
Förster, D; Reiser, G	1
Cinalli, AR; Fernández, V; Guarracino, JF; Losavio, AS; Roquel, LI	1
Chaudhary, PK; Kim, S	1
Chen, Q; Hu, X; Shao, Q; Wu, Z; Zhao, Z	1
Chaudhary, PK; Jee, Y; Kim, S; Lee, SH; Park, KM	1
Delicado, EG; Gil-Redondo, JC; Iturri, J; Miras-Portugal, MT; Ortega, F; Pérez-Sen, R; Toca-Herrera, JL; Weber, A	1
Dangelmaier, C; Kunapuli, SP	1
Chee, XW; Gunasinghe, KKJ; Harper, MT; Rahman, T; Vadlamani, VMK	1
Amaradasa, K; Bancroft, S; Dimofte, T; Hindle, MS; Hutchinson, JL; Johnson, T; Keith, M; Khalil, J; Mundell, SJ; Naseem, K; Roberts, T	1

Reviews

2 review(s) available for adenosine diphosphate and methylthio-adp

Article	Year
Purine and pyrimidine (P2) receptors as drug targets. Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19 Topics: Adenosine Triphosphate; Animals; Drug Design; Humans; Ligands; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Uridine Triphosphate	2002
P2Y12, a new platelet ADP receptor, target of clopidogrel. Seminars in vascular medicine, 2003, Volume: 3, Issue:2 Topics: Adenosine Diphosphate; Angina, Unstable; Animals; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Membrane Proteins; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Ticlopidine	2003

Article

Year

Purine and pyrimidine (P2) receptors as drug targets.

Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19

Topics: Adenosine Triphosphate; Animals; Drug Design; Humans; Ligands; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Uridine Triphosphate

2002

P2Y12, a new platelet ADP receptor, target of clopidogrel.

Seminars in vascular medicine, 2003, Volume: 3, Issue:2

Topics: Adenosine Diphosphate; Angina, Unstable; Animals; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Membrane Proteins; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Ticlopidine

2003

Trials

2 trial(s) available for adenosine diphosphate and methylthio-adp

Article	Year
Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase. Arteriosclerosis and thrombosis : a journal of vascular biology, 1992, Volume: 12, Issue:4 Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adult; Binding Sites; Blood Platelets; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Purinergic; Thionucleotides; Thrombin; Ticlopidine	1992
Differential sensitivity and kinetics of response of different ex vivo tests monitoring functional variability of platelet response to clopidogrel. Thrombosis and haemostasis, 2010, Volume: 104, Issue:3 Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Flow Cytometry; Humans; Kinetics; Male; Microfilament Proteins; Nephelometry and Turbidimetry; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thionucleotides; Thrombelastography; Ticlopidine; Young Adult	2010

Article

Year

Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase.

Arteriosclerosis and thrombosis : a journal of vascular biology, 1992, Volume: 12, Issue:4

Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adult; Binding Sites; Blood Platelets; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Purinergic; Thionucleotides; Thrombin; Ticlopidine

1992

Differential sensitivity and kinetics of response of different ex vivo tests monitoring functional variability of platelet response to clopidogrel.

Thrombosis and haemostasis, 2010, Volume: 104, Issue:3

Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Flow Cytometry; Humans; Kinetics; Male; Microfilament Proteins; Nephelometry and Turbidimetry; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thionucleotides; Thrombelastography; Ticlopidine; Young Adult

2010

Other Studies

127 other study(ies) available for adenosine diphosphate and methylthio-adp

Article	Year
Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives. Journal of medicinal chemistry, 1982, Volume: 25, Issue:10 Topics: Adenosine Diphosphate; Animals; Catalysis; Chemical Phenomena; Chemistry; In Vitro Techniques; Isoenzymes; Kidney; Liver; Pyruvate Kinase; Rats; Species Specificity	1982
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate. Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24 Topics: Adenine Nucleotides; Animals; Aorta; Colon; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth; Rabbits; Receptors, Purinergic P2; Structure-Activity Relationship; Sulfides; Turkeys; Type C Phospholipases; Vas Deferens	1993
An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor. British journal of pharmacology, 1997, Volume: 121, Issue:2 Topics: Adenosine Triphosphate; Dose-Response Relationship, Drug; Humans; Radioligand Assay; Receptors, Purinergic P2; Receptors, Purinergic P2Y1	1997
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Molecular pharmacology, 2002, Volume: 62, Issue:5 Topics: Adenosine Diphosphate; Animals; Cells, Cultured; Female; Humans; Insecta; Purinergic P2 Receptor Antagonists; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Tritium	2002
Pharmacological characterization of the human P2Y13 receptor. Molecular pharmacology, 2003, Volume: 64, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Kinetics; Receptors, Purinergic P2; Thionucleotides	2003
Identification of hydrolytically stable and selective P2Y(1) receptor agonists. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Adenosine Triphosphatases; Animals; Biomimetics; Cell Line, Tumor; Drug Design; Gastric Juice; Humans; Hydrogen-Ion Concentration; Hydrolysis; Nucleotides; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Substrate Specificity; Temperature	2009
A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold. Journal of medicinal chemistry, 2010, Mar-25, Volume: 53, Issue:6 Topics: Alkaline Phosphatase; Animals; Blood Glucose; Cell Line, Tumor; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Fasting; Humans; Insulin; Insulin Secretion; Male; Molecular Structure; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Serum; Structure-Activity Relationship	2010
Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist. Journal of medicinal chemistry, 2012, Sep-13, Volume: 55, Issue:17 Topics: Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Molecular Structure; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar	2012
Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists. Journal of medicinal chemistry, 2013, Jun-27, Volume: 56, Issue:12 Topics: Animals; Antioxidants; Biocompatible Materials; Drug Design; Drug Stability; Humans; Hydrolysis; Models, Molecular; Neuroprotective Agents; Nucleotides; PC12 Cells; Protein Conformation; Purinergic P2Y Receptor Agonists; Rats; Reactive Oxygen Species; Receptors, Purinergic P2Y	2013
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action. Journal of medicinal chemistry, 2015, Nov-12, Volume: 58, Issue:21 Topics: Animals; Antioxidants; Cells, Cultured; Drug Discovery; Humans; Hydrogen Peroxide; Hydrolysis; Iron; Models, Molecular; Neurons; Neuroprotective Agents; Nucleosides; Nucleotides; PC12 Cells; Phosphorothioate Oligonucleotides; Purinergic P2Y Receptor Agonists; Rats; Reactive Oxygen Species; Receptors, Purinergic P2Y1	2015
ADP receptor-induced activation of guanine-nucleotide-binding proteins in human platelet membranes. European journal of biochemistry, 1992, Jul-01, Volume: 207, Issue:1 Topics: 6-Phytase; Adenosine Diphosphate; Blood Platelets; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Platelet Aggregation; Receptors, Purinergic; Thionucleotides	1992
2-Methylthioadenosine [beta-32P]diphosphate: synthesis and use as probe of platelet ADP receptors. Methods in enzymology, 1992, Volume: 215 Topics: Adenosine Diphosphate; Blood Platelets; Humans; Indicators and Reagents; Kinetics; Phosphorus Radioisotopes; Radioligand Assay; Receptors, Purinergic; Thionucleotides	1992
Two mechanisms for inhibition of ADP-induced platelet shape change by 5'-p-fluorosulfonylbenzoyladenosine. Conversion to adenosine, and covalent modification at an ADP binding site distinct from that which inhibits adenylate cyclase. The Journal of biological chemistry, 1985, Jul-05, Volume: 260, Issue:13 Topics: Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Binding Sites; Blood Platelets; Cyclic AMP; Drug Synergism; Humans; Microscopy, Electron, Scanning; Thionucleotides	1985
Identification of two distinct adenosine diphosphate receptors in human platelets. Transactions of the Association of American Physicians, 1980, Volume: 93 Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Chymotrypsin; Cyclic AMP; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Receptors, Cell Surface; Receptors, Purinergic; Thionucleotides	1980
2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. The Journal of clinical investigation, 1983, Volume: 71, Issue:3 Topics: Adenosine Diphosphate; Blood Platelets; Cyclic AMP; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Receptors, Cell Surface; Receptors, Purinergic; Temperature; Thionucleotides	1983
Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid. British journal of pharmacology, 1984, Volume: 82, Issue:1 Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chlorpromazine; Humans; In Vitro Techniques; Indomethacin; Lipids; Malondialdehyde; Platelet Aggregation; Platelet Count; Quinacrine; Serotonin; Thionucleotides; Thrombin	1984
Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate. British journal of pharmacology, 1982, Volume: 77, Issue:2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Azides; Binding, Competitive; Humans; In Vitro Techniques; Platelet Aggregation; Thionucleotides	1982
Autoradiography of P2x ATP receptors in the rat brain. British journal of pharmacology, 1995, Volume: 115, Issue:2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Autoradiography; Binding, Competitive; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Dilazep; Female; Hippocampus; Ligands; Male; Ouabain; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Structure-Activity Relationship; Suramin; Thalamus; Thionucleotides	1995
An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function. The Journal of clinical investigation, 1995, Volume: 95, Issue:4 Topics: Adenosine Diphosphate; Alprostadil; Blood Coagulation Disorders; Blood Platelets; Cyclic AMP; Cytoplasmic Granules; Epinephrine; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Purinergic P2; Thionucleotides; White People	1995
Characterization of specific binding sites for [3H]2-MeS-ADP on megakaryocytoblastic cell lines in culture. Biochemical pharmacology, 1994, Jul-05, Volume: 48, Issue:1 Topics: Adenosine Diphosphate; Binding Sites; Cells, Cultured; Megakaryocytes; Thionucleotides; Tritium	1994
Effect of aspirin and clopidogrel on platelet-dependent tissue factor expression in endothelial cells. Thrombosis research, 1994, Jan-15, Volume: 73, Issue:2 Topics: Adenosine Diphosphate; Animals; Aorta; Aspirin; Blood Platelets; Cattle; Clopidogrel; Endothelium, Vascular; Female; Ligation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thionucleotides; Thrombin; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior	1994
Binding of [3H]-2-methylthio ADP to rat platelets--effect of clopidogrel and ticlopidine. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:2 Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Binding Sites; Blood Platelets; Clopidogrel; Female; In Vitro Techniques; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Ticlopidine	1994
Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors. British journal of haematology, 1995, Volume: 91, Issue:2 Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Female; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P2; Thionucleotides; Ticlopidine	1995
Characterisation of a recombinant P2Y purinoceptor. European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3 Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Animals; Brain; Cell Line; Electrophysiology; Inositol Phosphates; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Proteins; Suramin; Thionucleotides; Triazines; Uridine Triphosphate; Xenopus	1995
Effect of clopidogrel treatment on ADP-induced phosphorylations in rat platelets. British journal of haematology, 1997, Volume: 97, Issue:1 Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Female; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thionucleotides; Ticlopidine	1997
Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thro Thrombosis and haemostasis, 1997, Volume: 77, Issue:5 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Binding Sites; Blood Platelet Disorders; Blood Platelets; Cytoplasmic Granules; Female; Fibrinogen; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Phosphorus Radioisotopes; Platelet Aggregation; Reference Values; Serotonin; Thionucleotides; Thromboxane A2	1997
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors. Neuropharmacology, 1997, Volume: 36, Issue:9 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Humans; In Vitro Techniques; Inositol Phosphates; Kidney; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Stimulation, Chemical; Thionucleotides	1997
Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets. The Journal of biological chemistry, 1998, Jan-23, Volume: 273, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Calcium; Humans; Inositol Phosphates; Membrane Proteins; Models, Chemical; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides	1998
P2Y- and P2U-mediated increases in internal calcium in single bovine aortic endothelial cells in primary culture. Endothelium : journal of endothelial cell research, 1997, Volume: 5, Issue:4 Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Cattle; Cells, Cultured; Ion Transport; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Thionucleotides; Uridine Triphosphate	1997
Agonist action of adenosine triphosphates at the human P2Y1 receptor. Molecular pharmacology, 1998, Volume: 54, Issue:6 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Calcium; Cell Line; Dose-Response Relationship, Drug; Humans; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured	1998
Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets. Thrombosis and haemostasis, 1998, Volume: 80, Issue:6 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Blood Platelets; Blood Proteins; Enzyme Activation; Fibrinogen; Humans; Phospholipase D; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Purinergic Antagonists; Receptors, Thromboxane; Signal Transduction; Thionucleotides; Thrombin	1998
Benzoyl ATP is an antagonist of rat and human P2Y1 receptors and of platelet aggregation. Biochemical and biophysical research communications, 1999, Mar-05, Volume: 256, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Brain; Calcium; Cholera Toxin; Cyclic AMP; Endothelium, Vascular; Humans; Inhibitory Concentration 50; Jurkat Cells; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Transfection	1999
Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adnosine 5-diphosphate (ADP) in human platelets. British journal of pharmacology, 1999, Volume: 127, Issue:6 Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Cell Size; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Suramin; Thionucleotides; Trypanocidal Agents; Uridine Triphosphate	1999
[Preparation of 32P-labelled 2-methylthioadenosine di- and triphosphates]. Bioorganicheskaia khimiia, 1999, Volume: 25, Issue:9 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Chromatography, High Pressure Liquid; Phosphorus Radioisotopes; Phosphorylation; Radiochemistry; Thionucleotides	1999
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. British journal of pharmacology, 2000, Volume: 129, Issue:7 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium	2000
P2Y(1) purinoceptor-mediated Ca(2+) signaling and Ca(2+) wave propagation in dorsal spinal cord astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Apr-15, Volume: 20, Issue:8 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Embryo, Mammalian; Female; Posterior Horn Cells; Pregnancy; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; RNA, Messenger; Thionucleotides; Uridine Triphosphate	2000
Adenosine triphosphate is full antagonist at human P2Y(1) purinoceptors. Neuroscience letters, 2000, Apr-28, Volume: 284, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Cell Line; Creatine Kinase; Dose-Response Relationship, Drug; Half-Life; Humans; Inositol Phosphates; Phosphocreatine; Phosphorylation; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides	2000
Evidence that 2-methylthioATP and 2-methylthioADP are both agonists at the rat hepatocyte P2Y(1) receptor. British journal of pharmacology, 2000, Volume: 130, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium Signaling; Liver; Male; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2Y1; Thionucleotides; Uridine Triphosphate	2000
Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors. Biochemical and biophysical research communications, 2000, Jun-07, Volume: 272, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Aspartic Acid; Astrocytoma; Dose-Response Relationship, Drug; Humans; Phosphates; Phosphatidylinositols; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured	2000
Phosphate-substituted ATP analogs are antagonists at human P2Y1 purinoceptors. Archives of biochemistry and biophysics, 2000, Sep-01, Volume: 381, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Cell Line; Humans; In Vitro Techniques; Inositol Phosphates; Kinetics; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Thionucleotides	2000
Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747. British journal of pharmacology, 2001, Volume: 132, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cyclic AMP; Cyclopropanes; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; In Vitro Techniques; Male; Membrane Proteins; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes	2001
Dual effect of nucleotides on P2Y receptors. IUBMB life, 2000, Volume: 50, Issue:2 Topics: Adenosine Diphosphate; Binding Sites; Calcium; Cell Line; Dose-Response Relationship, Drug; Humans; Hydrolysis; Inhibitory Concentration 50; Ions; Kinetics; Ligands; Magnesium; Nucleotides; Phosphatidylinositols; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured; Uridine Diphosphate	2000
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19 Topics: Adenine Nucleotides; Adenosine Diphosphate; Annexin A5; Apoptosis; Astrocytoma; Carbachol; Carbazoles; Chromones; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; GTP-Binding Proteins; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Proteins; Thionucleotides; Transcription Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella	2001
The balance of concurrent aggregation and deaggregation processes in platelets is linked to differential occupancy of ADP receptor subtypes. Platelets, 2001, Volume: 12, Issue:2 Topics: Adenosine Diphosphate; Adult; Calcium Signaling; Cell Compartmentation; Female; Fibrinolytic Agents; Humans; Kinetics; Male; Membrane Proteins; Middle Aged; Models, Biological; Platelet Aggregation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides	2001
Extracellular ADP is a powerful osteolytic agent: evidence for signaling through the P2Y(1) receptor on bone cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:7 Topics: Adenosine Diphosphate; Animals; Bone and Bones; Bone Resorption; Calcium; Cells, Cultured; Chondrocytes; Immunohistochemistry; In Situ Hybridization; Mice; Osteoblasts; Osteoclasts; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides	2001
P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase. British journal of pharmacology, 2001, Volume: 134, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Division; Dinucleoside Phosphates; Enzyme Activation; Glioma; Hydrolysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Purinergic P2 Receptor Agonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Thionucleotides; Time Factors; Triazines; Tumor Cells, Cultured	2001
Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism. The Journal of membrane biology, 2002, Aug-01, Volume: 188, Issue:3 Topics: Adenosine; Adenosine Diphosphate; Animals; Calcium; Cell Line; Cell Membrane; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Hydrogen-Ion Concentration; Rats; Signal Transduction; Sodium-Hydrogen Exchangers; Thionucleotides; Transfection; Xenopus laevis	2002
Human Ntera-2/D1 neuronal progenitor cells endogenously express a functional P2Y1 receptor. Neuropharmacology, 2002, Volume: 43, Issue:6 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Antineoplastic Agents; Blotting, Western; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Fluorescence; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Humans; Membrane Proteins; Mitogen-Activated Protein Kinases; Neurons; Platelet Aggregation Inhibitors; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Receptors, Purinergic P2Y2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Suramin; Thionucleotides; Uridine Triphosphate	2002
The stable pyrimidines UDPbetaS and UTPgammaS discriminate between contractile cerebrovascular P2 receptors. European journal of pharmacology, 2003, Jan-05, Volume: 458, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Basilar Artery; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thionucleotides; Uridine Diphosphate; Uridine Triphosphate; Vasoconstriction	2003
Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP. British journal of haematology, 2003, Volume: 120, Issue:4 Topics: Adenosine Diphosphate; Adolescent; Adult; Benzylamines; Blood Platelets; Clopidogrel; Electrophoresis, Polyacrylamide Gel; Humans; Male; Membrane Proteins; Phosphorylation; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serine; Signal Transduction; Thiazoles; Thionucleotides; Threonine; Ticlopidine; Tyrosine	2003
Differential frequency dependence of P2Y1- and P2Y2- mediated Ca 2+ signaling in astrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jun-01, Volume: 23, Issue:11 Topics: Adenosine Diphosphate; Animals; Astrocytes; Astrocytoma; Biological Clocks; Calcium; Calcium Signaling; Cells, Cultured; Feedback, Physiological; Fluorescent Dyes; Humans; Mutagenesis, Site-Directed; Protein Kinase C; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Spectrometry, Fluorescence; Structure-Activity Relationship; Thionucleotides; Uridine Triphosphate	2003
ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Jun-01, Volume: 23, Issue:11 Topics: Acetylcholinesterase; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Chick Embryo; Cytosol; DNA-Binding Proteins; ets-Domain Protein Elk-1; Gene Expression Regulation; Genes, Reporter; Mice; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Myoblasts; Neuromuscular Junction; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins; Receptors, Cholinergic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Transcription Factors; Transcription, Genetic; Transduction, Genetic	2003
ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells. The Journal of physiology, 2003, Nov-01, Volume: 552, Issue:Pt 3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biological Clocks; Blotting, Western; Bufo marinus; Calcium; Electrophysiology; Heart; Immunohistochemistry; Intracellular Membranes; Myocardium; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sarcoplasmic Reticulum; Suramin; Thionucleotides; Type C Phospholipases	2003
Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor. Journal of thrombosis and haemostasis : JTH, 2004, Volume: 2, Issue:1 Topics: Actins; Adenosine Diphosphate; Animals; Cell Division; CHO Cells; Cricetinae; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; MAP Kinase Signaling System; Membrane Proteins; Models, Biological; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Recombinant Proteins; rhoA GTP-Binding Protein; Signal Transduction; Thionucleotides	2004
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B. Journal of neurochemistry, 2004, Volume: 89, Issue:2 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Animals; Cell Differentiation; Cell Division; Cell Line, Tumor; Cyclic AMP; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Adrenergic, beta; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides	2004
Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters. The Journal of biological chemistry, 2004, Jun-25, Volume: 279, Issue:26 Topics: Acetylcholinesterase; Adenosine Diphosphate; Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Chickens; Collagen; DNA-Binding Proteins; Exons; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Mice; Molecular Sequence Data; Muscle Fibers, Fast-Twitch; Muscle Fibers, Skeletal; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Neuregulins; NFATC Transcription Factors; Nuclear Proteins; Promoter Regions, Genetic; Rats; Regulatory Sequences, Nucleic Acid; Synaptic Transmission; Thionucleotides; Transcription Factors; Transcription, Genetic; Transfection	2004
Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. Blood, 2004, Sep-01, Volume: 104, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Diphosphate; Animals; Antihypertensive Agents; Benzazepines; Blood Platelets; Blotting, Western; Cytoplasmic Granules; Dopamine Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Membrane Proteins; Mice; Peptide Fragments; Phosphorylation; Platelet Aggregation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides	2004
Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells. Pflugers Archiv : European journal of physiology, 2004, Volume: 449, Issue:1 Topics: Adenosine Diphosphate; Animals; Calcium; Cell Line; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Glyburide; Indomethacin; Isoquinolines; Kidney Tubules; Phosphoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sodium-Hydrogen Exchangers; Sulfonamides; Thionucleotides; Xenopus laevis	2004
Use of radiolabeled 2-methylthio-ADP to study P2Y receptors on platelets and cell lines. Methods in molecular biology (Clifton, N.J.), 2004, Volume: 273 Topics: Adenosine Diphosphate; Blood Platelets; Cell Line; Humans; Phosphorus Isotopes; Platelet Function Tests; Receptors, Purinergic P2; Thionucleotides	2004
Arg333 and Arg334 in the COOH terminus of the human P2Y1 receptor are crucial for Gq coupling. American journal of physiology. Cell physiology, 2005, Volume: 288, Issue:3 Topics: Adenosine Diphosphate; Alanine; Amino Acid Sequence; Animals; Arginine; CHO Cells; Cricetinae; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Molecular Sequence Data; Protein Structure, Tertiary; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thionucleotides	2005
ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells. Circulation research, 2005, Feb-04, Volume: 96, Issue:2 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Apyrase; Cyclic AMP; Epinephrine; Erythrocyte Membrane; Erythrocytes; Feedback, Physiological; Female; Humans; Male; Microdialysis; Phentolamine; Propranolol; Receptors, Purinergic P2; Reticulocytes; RNA, Messenger; Sus scrofa; Thionucleotides	2005
Bi-functional effects of ATP/P2 receptor activation on tumor necrosis factor-alpha release in lipopolysaccharide-stimulated astrocytes. Journal of neurochemistry, 2005, Volume: 92, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Astrocytes; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Lipopolysaccharides; Purinergic P2 Receptor Agonists; Rats; Rats, Inbred F344; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X7; Stimulation, Chemical; Thionucleotides; Tumor Necrosis Factor-alpha	2005
Metabotropic P2Y purinoceptor-mediated presynaptic and postsynaptic enhancement of cerebellar GABAergic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Feb-23, Volume: 25, Issue:8 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Diphosphate; Animals; Calcium; Cerebellar Cortex; Chelating Agents; Egtazic Acid; Female; gamma-Aminobutyric Acid; Interneurons; Long-Term Potentiation; Male; Neuroglia; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Presynaptic; Receptors, Purinergic P2; Synaptic Transmission; Tetrodotoxin; Thionucleotides; Xanthines	2005
Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Neuroscience research, 2005, Volume: 51, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Electric Stimulation; Female; Hot Temperature; Nerve Fibers, Unmyelinated; Nociceptors; Organ Culture Techniques; Purinergic Agonists; Rats; Rats, Inbred Lew; Skin; Stimulation, Chemical; Thionucleotides; Uridine Triphosphate	2005
Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons. European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Receptors, Purinergic P2Y1; Thionucleotides	2005
Changes in purinergic signalling in developing and ageing rat tail artery: importance for temperature control. Neuropharmacology, 2006, Volume: 50, Issue:2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Arteries; Dose-Response Relationship, Drug; Electric Stimulation; Immunohistochemistry; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Regional Blood Flow; Signal Transduction; Suramin; Tail; Thionucleotides; Uridine Triphosphate	2006
Differential coupling of the P2Y1 receptor to Galpha14 and Galphaq/11 proteins during the development of the rat salivary gland. Archives of oral biology, 2006, Volume: 51, Issue:5 Topics: Adenosine Diphosphate; Animals; Blotting, Northern; Blotting, Western; Calcium; Calcium Signaling; Carbachol; Edetic Acid; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Muscarinic Agonists; Phosphorylation; Protein Binding; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Reverse Transcriptase Polymerase Chain Reaction; Salivary Glands; Thionucleotides	2006
Postnatal development of P2 receptors in the murine gastrointestinal tract. Neuropharmacology, 2006, Volume: 50, Issue:6 Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Dose-Response Relationship, Drug; Female; Gastrointestinal Tract; Gene Expression Regulation, Developmental; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Thionucleotides; Uridine Triphosphate	2006
Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes. Glia, 2006, Nov-01, Volume: 54, Issue:6 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Brain; Cell Death; Cell Nucleus; Cells, Cultured; Enzyme Activation; Extracellular Fluid; Hydrogen Peroxide; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; src-Family Kinases; Thionucleotides; Thioredoxin-Disulfide Reductase	2006
The ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia. Journal of thrombosis and thrombolysis, 2007, Volume: 24, Issue:2 Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Hyperemia; Myocardial Ischemia; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Swine; Thionucleotides; Tissue Plasminogen Activator	2007
ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia, 2007, Volume: 55, Issue:8 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Chemotaxis; Green Fluorescent Proteins; Male; Membrane Potentials; Mice; Mice, Transgenic; Microglia; Organ Culture Techniques; Patch-Clamp Techniques; Potassium; Receptors, Purinergic P2; Thionucleotides	2007
A role for Akt in epidermal growth factor-stimulated cell cycle progression in cultured hepatocytes: generation of a hyperproliferative window after adenoviral expression of constitutively active Akt. The Journal of pharmacology and experimental therapeutics, 2007, Volume: 321, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenoviridae; Animals; Cell Cycle; Cell Proliferation; Cell Survival; Epidermal Growth Factor; Glycogen Phosphorylase; Hepatocytes; Inositol Phosphates; Insulin; Male; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; S Phase; Thionucleotides; TOR Serine-Threonine Kinases; Transfection; Uridine Diphosphate; Uridine Triphosphate	2007
The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening. Analytical biochemistry, 2007, May-15, Volume: 364, Issue:2 Topics: Adenosine Diphosphate; Astrocytoma; Binding Sites; Binding, Competitive; Chromatography, Affinity; Deoxyadenine Nucleotides; Humans; Membranes, Artificial; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sensitivity and Specificity; Thionucleotides; Transfection; Tumor Cells, Cultured	2007
Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons. Journal of neurochemistry, 2008, Volume: 104, Issue:1 Topics: Adenosine Diphosphate; Animals; Animals, Newborn; beta Catenin; Cell Nucleus; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; GTP-Binding Protein alpha Subunits, Gi-Go; Neurons; Phosphorylation; Rats; Rats, Wistar; Receptors, Purinergic P2; Signal Transduction; Thionucleotides; Time Factors	2008
ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. Circulation research, 2008, Feb-29, Volume: 102, Issue:4 Topics: Adenosine Diphosphate; Cell Movement; Cells, Cultured; Chemotaxis; Endothelial Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Umbilical Veins	2008
Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation. Biochemical pharmacology, 2008, Mar-15, Volume: 75, Issue:6 Topics: Adenosine Diphosphate; Calcium; Cell Line, Tumor; Cells, Cultured; Humans; Platelet Aggregation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thionucleotides; Transfection; Ultraviolet Rays	2008
Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction. Neuroscience, 2008, Jul-17, Volume: 154, Issue:4 Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine Diphosphate; Animals; Calcium; Electrophysiology; Exocytosis; Mice; Neuromuscular Junction; Purinergic P2 Receptor Agonists; Purines; Synaptic Transmission; Thionucleotides	2008
Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Sep-10, Volume: 28, Issue:37 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Movement; Cell Proliferation; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Electroencephalography; Fluoresceins; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Organic Chemicals; Patch-Clamp Techniques; Purines; Receptors, Chemokine; Receptors, Purinergic; RNA, Messenger; Signal Transduction; Status Epilepticus; Thionucleotides; Time Factors; Up-Regulation	2008
Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor. Biochemical pharmacology, 2008, Nov-15, Volume: 76, Issue:10 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Amino Acid Motifs; Animals; Binding Sites; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides	2008
RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets. Biochemical pharmacology, 2009, Mar-01, Volume: 77, Issue:5 Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Blotting, Western; Cytoplasmic Granules; Enzyme Activation; GTP-Binding Proteins; Humans; In Vitro Techniques; Oligopeptides; Peptides, Cyclic; Protein Kinase C-delta; Receptor, PAR-1; Receptors, Thrombin; rhoA GTP-Binding Protein; Thionucleotides; Type C Phospholipases	2009
Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability. Thrombosis and haemostasis, 2009, Volume: 101, Issue:1 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine	2009
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. Neurochemistry international, 2009, Volume: 55, Issue:7 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Arteries; Blotting, Western; Desipramine; Epididymis; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Sympathetic Nervous System; Thionucleotides; Vas Deferens	2009
Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. American journal of physiology. Regulatory, integrative and comparative physiology, 2009, Volume: 297, Issue:2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium Signaling; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Perfusion; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Supraoptic Nucleus; Thapsigargin; Thionucleotides; Vasopressins	2009
Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 331, Issue:2 Topics: Adenosine Diphosphate; Animals; Arginine; Binding, Competitive; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclic AMP Response Element Modulator; Humans; Isomerism; Luciferases; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sulfonic Acids; Suramin; Thionucleotides; Triazines	2009
Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats. Clinical science (London, England : 1979), 2010, Volume: 118, Issue:7 Topics: Acetylcholine; Adenosine Diphosphate; Angiotensin II; Animals; Blotting, Western; Clopidogrel; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Ticlopidine; Vasodilation; Vasodilator Agents	2010
Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes. American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:3 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Fibrinolytic Agents; Ionophores; Kinetics; Male; Megakaryocytes; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Potassium; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Purinergic; Receptors, Thromboxane; Signal Transduction; Thionucleotides	2010
Distinct migratory and cytokine responses of human microglia and macrophages to ATP. Brain, behavior, and immunity, 2010, Volume: 24, Issue:8 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Brain; Cell Movement; Chemokine CCL2; Cytokines; Female; Fetus; Flow Cytometry; Humans; In Vitro Techniques; Indicators and Reagents; Interleukin-10; Interleukin-6; Lipopolysaccharides; Macrophages; Microglia; Pregnancy; Purinergic P2Y Receptor Agonists; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Necrosis Factor-alpha	2010
The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death. Free radical biology & medicine, 2010, Aug-01, Volume: 49, Issue:3 Topics: Adenosine Diphosphate; Animals; Cell Death; Cells, Cultured; Heme Oxygenase-1; Mice; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Rats; Receptors, Purinergic P2; Thionucleotides	2010
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice. Diabetologia, 2010, Volume: 53, Issue:9 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apyrase; Cell Line; Cells, Cultured; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Polymerase Chain Reaction; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides	2010
TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. Journal of neurochemistry, 2010, Volume: 115, Issue:2 Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Calcium; Cell Movement; Cells, Cultured; Cerebral Cortex; Gene Expression Regulation; Interferon-gamma; Lipopolysaccharides; Microglia; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; RNA, Small Interfering; Thionucleotides; Transforming Growth Factor beta	2010
Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery. Journal of pharmacological sciences, 2010, Volume: 114, Issue:2 Topics: Adenosine Diphosphate; Animals; Apamin; Arachidonic Acids; Arginine; Biological Factors; Cerebral Arteries; Charybdotoxin; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Female; Glycyrrhetinic Acid; Macaca; Male; Nitric Oxide; Nitroprusside; Thionucleotides; Vasodilation	2010
Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:12 Topics: Adenosine Diphosphate; Carotid Artery Diseases; Cell Proliferation; Cells, Cultured; Cyclic AMP; Humans; Interleukin-6; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Piperazines; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; RNA Interference; RNA, Messenger; Thionucleotides; Thrombin; Time Factors; Transcriptional Activation; Up-Regulation	2010
Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria. PloS one, 2010, Dec-22, Volume: 5, Issue:12 Topics: Adenosine Diphosphate; Animals; Astrocytes; Brain Infarction; Cerebral Infarction; Edema; Inositol 1,4,5-Trisphosphate; Light; Male; Mice; Mitochondria; Neuroglia; Receptors, Purinergic; Receptors, Purinergic P2Y1; Thionucleotides; Thrombosis	2010
An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma. Thrombosis and haemostasis, 2011, Volume: 105, Issue:4 Topics: Adenosine Diphosphate; Animals; Blood Platelets; CHO Cells; Chromatography, High Pressure Liquid; Clopidogrel; Cricetinae; Cricetulus; Humans; Mass Spectrometry; Phosphorus Isotopes; Plasma; Product Surveillance, Postmarketing; Protein Binding; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Stereoisomerism; Thionucleotides; Ticlopidine; Transgenes	2011
Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved. Neuroscience, 2011, May-19, Volume: 182 Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Astrocytes; Cell Proliferation; Cells, Cultured; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thionucleotides	2011
Calcium dependence of purinergic subtype P2Y₁ receptor modulation of C6 glioma cell migration. Neuroscience letters, 2011, Jun-22, Volume: 497, Issue:2 Topics: Adenosine Diphosphate; Animals; Brain Neoplasms; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Line, Tumor; Cell Movement; Glioma; Intracellular Fluid; Ion Channel Gating; Neoplasm Invasiveness; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y1; Thionucleotides; Time Factors	2011
Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors. British journal of pharmacology, 2011, Volume: 164, Issue:5 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Cell Culture Techniques; Cloning, Molecular; Electric Stimulation; Green Fluorescent Proteins; KCNQ Potassium Channels; Maximum Tolerated Dose; Neurons; Neurotransmitter Agents; Norepinephrine; Patch-Clamp Techniques; PC12 Cells; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Receptors, Purinergic P2Y1; Superior Cervical Ganglion; Synaptic Transmission; Thionucleotides	2011
Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase. The Journal of biological chemistry, 2011, Jul-08, Volume: 286, Issue:27 Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Enzyme Activation; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Mice; Mice, Mutant Strains; Oligopeptides; Peptide Fragments; Platelet Aggregation; Protein Kinase C; Proto-Oncogene Proteins c-fyn; Thionucleotides	2011
Adenosine diphosphate receptor P2Y12-mediated migration of host smooth muscle-like cells and leukocytes in the development of transplant arteriosclerosis. Transplantation, 2011, Jul-27, Volume: 92, Issue:2 Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Bone Marrow; Carotid Arteries; Cell Movement; Chemokine CCL2; Leukocyte Common Antigens; Leukocytes; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Muscle, Smooth, Vascular; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides	2011
ERK1/2 activation is involved in the neuroprotective action of P2Y13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons. Neuropharmacology, 2011, Volume: 61, Issue:8 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; MAP Kinase Signaling System; Neurons; Phosphorylation; Purinergic P2X Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Thionucleotides; Time Factors	2011
Functional contribution of P2Y1 receptors to the control of coronary blood flow. Journal of applied physiology (Bethesda, Md. : 1985), 2011, Volume: 111, Issue:6 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arterioles; Blood Flow Velocity; Coronary Circulation; Dogs; Hyperemia; In Vitro Techniques; Male; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Thionucleotides; Vasodilation	2011
P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices. Journal of neurophysiology, 2012, Volume: 107, Issue:3 Topics: Action Potentials; Adenosine Diphosphate; Animals; Animals, Newborn; Apamin; Calcium; Corpus Striatum; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Neurons; Peptides; Potassium; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Small-Conductance Calcium-Activated Potassium Channels; Tetraethylammonium; Thionucleotides	2012
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration. Journal of neurochemistry, 2012, Volume: 121, Issue:2 Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Animals; Animals, Newborn; Cell Movement; Cells, Cultured; Cerebral Cortex; Chemotaxis; Collagen; Flow Cytometry; Indicators and Reagents; JNK Mitogen-Activated Protein Kinases; Microglia; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Purinergic P2Y12; Thionucleotides	2012
Mechanisms underlying reduced P2Y(1) -receptor-mediated relaxation in superior mesenteric arteries from long-term streptozotocin-induced diabetic rats. Acta physiologica (Oxford, England), 2013, Volume: 207, Issue:1 Topics: Adenosine Diphosphate; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitric Oxide Synthase Type III; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Time; Vasodilation	2013
Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes. PloS one, 2013, Volume: 8, Issue:3 Topics: Adenosine Diphosphate; Animals; Arrestins; beta-Arrestins; Blood Platelets; Calcium; CHO Cells; Cricetulus; Cyclic AMP; Cysteine; HEK293 Cells; Humans; Inflammation; Leukotriene E4; Leukotrienes; Mice; Platelet Activation; Purinergic P2Y Receptor Agonists; Receptors, Leukotriene; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides	2013
Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets. The Journal of biological chemistry, 2013, Jun-21, Volume: 288, Issue:25 Topics: Adenosine Diphosphate; Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thionucleotides; Thromboxane A2; Time Factors; Tyrphostins	2013
RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation. The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47 Topics: Adenosine Diphosphate; Animals; Anticoagulants; Carrier Proteins; Crotalid Venoms; Female; GTP Phosphohydrolases; Humans; Lectins, C-Type; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Oligopeptides; Peptides; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Polysaccharides; Protein Kinases; Receptors, Fc; rho GTP-Binding Proteins; Thionucleotides; Thrombosis	2013
Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor. Journal of neurochemistry, 2014, Volume: 129, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Substitution; Astrocytoma; Autoimmunity; Brain; Calcium Signaling; Cell Line, Tumor; Cyclic AMP; HEK293 Cells; Humans; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Protein Interaction Mapping; Purinergic Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Structure-Activity Relationship; Thionucleotides; Transfection	2014
Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats. PloS one, 2014, Volume: 9, Issue:3 Topics: Adenosine Diphosphate; Animals; Aorta; Blood Pressure; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertension; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y; Thionucleotides; Ticlopidine; Vascular Remodeling; Vasoconstriction; Vasodilation	2014
Agonist-bound structure of the human P2Y12 receptor. Nature, 2014, May-01, Volume: 509, Issue:7498 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Binding Sites; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Niacin; Protein Conformation; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Substrate Specificity; Sulfonamides; Thionucleotides	2014
Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery. Biochimica et biophysica acta, 2014, Volume: 1843, Issue:9 Topics: Adenosine Diphosphate; Animals; Caspase 3; Cell Death; Cell Nucleus; Cerebellum; Cisplatin; Cytoprotection; DNA Damage; Dual Specificity Phosphatase 2; Enzyme Activation; MAP Kinase Signaling System; Models, Biological; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Wistar; Receptors, Purinergic P2; Thionucleotides; Ultraviolet Rays	2014
SAR216471, an alternative to the use of currently available P2Y₁₂ receptor inhibitors? Thrombosis research, 2014, Volume: 134, Issue:3 Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Biological Availability; Blood Platelets; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Humans; Indoles; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Antagonists; Pyridazines; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides; Thrombosis; Transfection	2014
RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain. Glia, 2015, Volume: 63, Issue:2 Topics: Adenosine Diphosphate; Animals; Calcium-Binding Proteins; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Microfilament Proteins; Microglia; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Thionucleotides	2015
Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor. Journal of thrombosis and haemostasis : JTH, 2014, Volume: 12, Issue:11 Topics: Adenosine; Adenosine Diphosphate; Animals; Binding Sites; Binding, Competitive; CHO Cells; Colforsin; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Humans; Luciferases; Mutation; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Response Elements; Thionucleotides; Ticagrelor; Transfection	2014
Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PloS one, 2014, Volume: 9, Issue:10 Topics: Adenosine Diphosphate; Antineoplastic Agents; Aorta; Apoptosis; Azo Compounds; Cell Line; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Monocytes; Nucleolin; Phosphoproteins; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Purinergic Agonists; Purinergic Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; RNA-Binding Proteins; RNA, Messenger; S Phase Cell Cycle Checkpoints; Signal Transduction; Thionucleotides	2014
STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. Glia, 2015, Volume: 63, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Culture Techniques; Indoles; Lipopolysaccharides; Membrane Glycoproteins; Mice; Mice, Knockout; Mice, Transgenic; Microglia; ORAI1 Protein; Phagocytosis; Stromal Interaction Molecule 1; Stromal Interaction Molecule 2; Thionucleotides; Uridine Diphosphate	2015
Active site and remote contributions to catalysis in methylthioadenosine nucleosidases. Biochemistry, 2015, Apr-21, Volume: 54, Issue:15 Topics: Adenosine Diphosphate; Alanine; Amino Acid Substitution; Catalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Mutation, Missense; N-Glycosyl Hydrolases; Thionucleotides; Valine; Vibrio cholerae	2015
Two disparate ligand-binding sites in the human P2Y1 receptor. Nature, 2015, Apr-16, Volume: 520, Issue:7547 Topics: Adenosine Diphosphate; Binding Sites; Crystallography, X-Ray; Deoxyadenine Nucleotides; Humans; Ligands; Models, Molecular; Molecular Conformation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Thionucleotides; Uracil	2015
Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors. Neurochemistry international, 2016, Volume: 94 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Antioxidants; Cell Survival; Cells, Cultured; Cytoprotection; Hydrogen Peroxide; Neuroprotective Agents; Nucleotides; Rats; Receptors, Purinergic P2Y; Thionucleotides	2016
P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction. Neuroscience, 2016, 06-21, Volume: 326 Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Female; Male; Mice; Miniature Postsynaptic Potentials; Neuromuscular Junction; Purinergic P2 Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides	2016
Characterization of the distinct mechanism of agonist-induced canine platelet activation. Journal of veterinary science, 2019, Jan-31, Volume: 20, Issue:1 Topics: Adenosine Diphosphate; Animals; Blood Platelets; Dogs; Female; Hemostatics; Male; Oligopeptides; Platelet Aggregation; Receptors, Purinergic P2Y; Thionucleotides; Thrombin	2019
A Selective P2Y Purinergic Receptor Agonist 2-MesADP Enhances Locomotor Recovery after Acute Spinal Cord Injury. European neurology, 2020, Volume: 83, Issue:2 Topics: Adenosine Diphosphate; Animals; Doublecortin Protein; Gene Expression Regulation; Humans; Locomotion; Mice; Nerve Regeneration; Purinergic Agonists; Recovery of Function; Remyelination; Spinal Cord Injuries; Thionucleotides	2020
Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization. International journal of molecular sciences, 2020, May-30, Volume: 21, Issue:11 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Female; G-Protein-Coupled Receptor Kinases; Gene Expression Regulation; Hemostatics; Male; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Activation; Platelet Aggregation; Receptors, G-Protein-Coupled; Thionucleotides; Thrombin; Thromboxane A2	2020
Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy. International journal of molecular sciences, 2021, Jan-10, Volume: 22, Issue:2 Topics: Adenosine Diphosphate; Astrocytes; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Atomic Force; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Uridine Triphosphate	2021
Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets. Platelets, 2022, Nov-17, Volume: 33, Issue:8 Topics: Adenosine Diphosphate; Adenylyl Cyclases; Blood Platelets; Calcium; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Purinergic P2Y Receptor Antagonists; rap GTP-Binding Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thionucleotides; Type C Phospholipases	2022
Human soluble CD39 displays substrate inhibition in a substrate-specific manner. Scientific reports, 2023, 06-02, Volume: 13, Issue:1 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Apyrase; Humans; Uridine Diphosphate	2023
Ticagrelor inverse agonist activity at the P2Y British journal of pharmacology, 2024, Volume: 181, Issue:1 Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Blood Platelets; Diphosphates; Drug Inverse Agonism; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor	2024