Page last updated: 2024-08-17

adenosine diphosphate and hirudin

adenosine diphosphate has been researched along with hirudin in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (33.78)	18.7374
1990's	21 (28.38)	18.2507
2000's	18 (24.32)	29.6817
2010's	9 (12.16)	24.3611
2020's	1 (1.35)	2.80

Authors

Authors	Studies
Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Perry, DW	1
Henderson, RF; Henderson, TR; York, JL	1
Day, HJ; Holmsen, H; Macfarlane, DE; Mills, DC; Walsh, PN	1
Bygdeman, S; Tangen, O	1
Michaeli, D; Orloff, KG	1
Lieberman, GE; Nath, N; Niewiarowski, S; Sha, AT; Stewart, GJ	1
Degenhardt, T; Dodt, J; Knapp, A	1
Ballon, BC; Gerrard, JM; Greenberg, AH; Spearman, MA; Wright, JA	1
Glusa, E	2
Basic-Micic, M; Breddin, HK; Rauschenbach, C	1
Bellinger, OK; Breddin, HK; Kirchmaier, CM; Schulz, B	1
Bozarth, JM; Chiu, AT; Mousa, SA; Pease, LJ; Reilly, TM; Roscoe, WA; Smith, RD; Timmermans, PB	1
Badimon, JJ; Badimon, L; Chesebro, JH; Fuster, V; Heras, M; Lassila, R	1
Glusa, E; Urban, U	1
Holmsen, H; Steen, VM; Tysnes, OB	1
Dionigi, P; Fratino, P; Grignani, G; Jemos, V; Pacchiarini, L; Ricetti, MM; Zucchella, M	1
Holmsen, H; Koike, K	1
Bevilacqua, C; Cattaneo, M; Kinlough-Rathbone, RL; Lecchi, A; Mustard, JF; Packham, MA	1
Kinlough-Rathbone, RL; Lalau Keraly, C; Mustard, JF; Packham, MA; Suzuki, H	1
Connellan, JM; Louis, CJ; Scarlett, JD; Thurlow, PJ	1
Abecassis, J; Beretz, A; Cazenave, JP; Eber, M; Fricker, JP; Klein-Soyer, C; Millon-Collard, R; Muller, D; Nicora, F	1
Detwiler, TC; Yeo, KT	1
Ma, YH; Ouyang, CH; Teng, CM	1
Mustard, JF; Niewiarowski, S; Regoeczi, E; Senyl, AF; Stewart, GJ	1
Dangelmaier, CA; Holmsen, H; Rongved, S	1
Dangelmaier, CA; Holmsen, H; Holmsen, HK	1
Anderson, ER; Au-Young, YK; Foulks, JG	1
Lages, B; Weiss, HJ	1
Cox, CP; Farr, RS; Jorgensen, R; Wardlow, ML	1
Bastida, E; Jamieson, GA; Ordinas, A	1
Baldini, MG; Hara, Y; Steiner, M	1
Glusa, E; Markwardt, F	1
Côté, YP; Feinstein, MB; Lau, LF; Pumiglia, K	1
Armstrong, R; Heptinstall, S; Lösche, W; May, JA	1
Blaes, N; Covacho, C	1
Bretschneider, E; Glusa, E; Schrör, K	1
Akkawat, B; Cattaneo, M; Cimminiello, C; Kinlough-Rathbone, RL; Mannucci, PM; Packham, MA	1
Alkhamis, TM; Beissinger, RL; Chediak, JR	1
Druker, BJ; Handa, M; Ikeda, Y; Kato, T; Miyakawa, Y; Miyazaki, H; Oda, A; Ozaki, K; Shimosaka, A; Shirasawa, Y; Yabusaki, K	1
Frölich, JC; Tsikas, D; Viigimaa, M	1
Bentley, R; Bostwick, JS; Dunwiddie, CT; Kasiewski, CJ; Leadley, RJ; McVey, MJ; Perrone, MH; White, FJ	1
Dobner, P; Engelmann, B; Hermetter, A; Kögl, C; Schaipp, B; Siess, W; Stoeckelhuber, M	1
Heptinstall, S; Storey, RF; Wilcox, RG	1
Hornstra, G; Mensink, RP; Temme, EH	1
Edwards, N; Fox, SC; Henderson, RA; Heptinstall, S; Pascoe, J; Sanderson, HM; White, A	1
Fitzgerald, DJ; Harriott, P; McRedmond, JP; Walker, B	1
Maayani, S; Martinez, R; Schwarz, T; Tagliente, TM	1
Aggarwal, A; Schneider, DJ; Sobel, BE	1
Lindahl, TL; Ramström, S; Rånby, M	1
Glenn, JR; Heptinstall, S; Pink, AE; Stafford, NP; White, AE	1
Herrmann, M; Kehrel, BE; Morgenstern, E; Niemann, S; Peters, G; Spehr, N; Van Aken, H	1
Heptinstall, S; May, JA	1
Aiura, K; Kitajima, M; Suzuki, K; Ueda, M	1
Heptinstall, S; May, JA; Storey, RF	1
Calatzis, A; Losonczy, H; Penz, S; Siess, W; Tóth, O	1
Breuer, M; Dietz, K; Peter, K; Straub, A; Wendel, HP; Ziemer, G	1
Fox, SC; Heptinstall, S; White, AE; Wilcox, RG; Xavier, RG	1
Braun, S; Busch, G; Jawansky, S; Kastrati, A; Ott, I; Schömig, A; Sibbing, D; von Beckerath, N	1
Dovlatova, N; Heptinstall, S; Johnson, A	1
Schneider, DJ; Sobel, BE	2
Kalb, ML; Kozek-Langenecker, SA; Potura, L; Scharbert, G	1
Antonino, MJ; Bassi, AK; Bliden, KP; DiChiara, J; Gesheff, TB; Gurbel, PA; Hennebry, TA; Herzog, WR; Mahla, E; Saucedo, JF; Singla, A; Suarez, TA; Tantry, US	1
Baumgarten, A; Kalbantner, K; Mischke, R	1
Baumgarten, A; Ganter, M; Kalbantner, K; Mischke, R; Wilhelmi, M	1
Khandoga, AL; Penz, SM; Schober, LJ; Siess, W	1
Hellis, M; Lindhoff-Last, E; Mani, H	1
Bonnefoy, A; Cointe, S; Ghitescu, M; Martel, C; Matar, S; Maurice, P; Théroux, P	1
Kim, MH; Yu, LH; Zhang, HZ	1
Dai, L; Huang, Y; Liu, X; Mo, W; Wang, J; Wang, L; Wu, Y; Yu, M; Zhang, Y	1
Hakimi, CS; Jeppsson, A; Karlsson, M; Roman-Emanuel, C; Thimour-Bergström, L	1
Beck, J; Castellino, FJ; Davis, P; Donahue, DL; Fritz, B; Ploplis, VA; Sandoval-Cooper, MJ; Thomas, SG; Walsh, M; Yount, RA	1
Hvas, AM; Nissen, PH; Skipper, MT	1

Reviews

1 review(s) available for adenosine diphosphate and hirudin

Article	Year
Hirudin and platelets. Seminars in thrombosis and hemostasis, 1991, Volume: 17, Issue:2 Topics: Adenosine Diphosphate; Blood Platelets; Calcium Chloride; Citrates; Citric Acid; Collagen; Epinephrine; Hirudins; Humans; Platelet Adhesiveness; Platelet Aggregation; Recombinant Fusion Proteins; Serotonin; Thrombin; Thromboxane A2	1991

Trials

4 trial(s) available for adenosine diphosphate and hirudin

Article	Year
Differential effects of glycoprotein IIb/IIIa antagonists on platelet microaggregate and macroaggregate formation and effect of anticoagulant on antagonist potency. Implications for assay methodology and comparison of different antagonists. Circulation, 1998, Oct-20, Volume: 98, Issue:16 Topics: Adenosine Diphosphate; Anticoagulants; Citrates; Collagen; Eptifibatide; Hirudins; Humans; Nephelometry and Turbidimetry; Oligopeptides; Peptides; Peptides, Cyclic; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Sodium Citrate; Thiazolidines	1998
Individual saturated fatty acids and effects on whole blood aggregation in vitro. European journal of clinical nutrition, 1998, Volume: 52, Issue:10 Topics: Adenosine Diphosphate; Adult; Anticoagulants; Collagen; Cross-Over Studies; Diet; Dietary Fats; Energy Intake; Fatty Acids; Female; Hirudins; Humans; Lauric Acids; Male; Middle Aged; Myristic Acid; Oleic Acid; Palmitic Acid; Platelet Aggregation; Recombinant Proteins; Thromboxane A2; Thromboxane B2	1998
Impact of bivalirudin or unfractionated heparin on platelet aggregation in patients pretreated with 600 mg clopidogrel undergoing elective percutaneous coronary intervention. European heart journal, 2008, Volume: 29, Issue:12 Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Clopidogrel; Double-Blind Method; Female; Heparin; Hirudins; Humans; Male; Peptide Fragments; Perioperative Care; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Premedication; Recombinant Proteins; Ticlopidine	2008
Bivalirudin and clopidogrel with and without eptifibatide for elective stenting: effects on platelet function, thrombelastographic indexes, and their relation to periprocedural infarction results of the CLEAR PLATELETS-2 (Clopidogrel with Eptifibatide to Journal of the American College of Cardiology, 2009, Feb-24, Volume: 53, Issue:8 Topics: Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Anticoagulants; Blood Coagulation; Blood Platelets; Clopidogrel; Collagen; Drug Therapy, Combination; Eptifibatide; Female; Hemorheology; Hirudins; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Recombinant Proteins; Stents; Thrombelastography; Ticlopidine	2009

Other Studies

69 other study(ies) available for adenosine diphosphate and hirudin

Article	Year
Factors responsible for ADP-induced release reaction of human platelets. The American journal of physiology, 1975, Volume: 228, Issue:6 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Citrates; Fibrinogen; gamma-Globulins; Hemophilia A; Heparin; Hirudins; Humans; Magnesium; Phenylbutazone; Phosphates; Platelet Adhesiveness; Platelet Aggregation; Serum Albumin; Sulfinpyrazone; Thrombin	1975
Effects of dimethyl sulfoxide on subunit proteins. Annals of the New York Academy of Sciences, 1975, Jan-27, Volume: 243 Topics: Adenosine Diphosphate; Animals; Blood Coagulation; Cattle; Dimethyl Sulfoxide; Enzyme Activation; Fibrinogen; Glucuronidase; Glutamate Dehydrogenase; Hirudins; Hydrogen-Ion Concentration; Kinetics; Liver; Protein Denaturation; Proteins; Temperature; Thrombin	1975
The role of thrombin in ADP-induced platelet aggregation and release: a critical evaluation. British journal of haematology, 1975, Volume: 30, Issue:4 Topics: Adenosine Diphosphate; Blood Coagulation Factors; Edetic Acid; Heparin; Hirudins; Humans; Platelet Aggregation; Thrombin	1975
Studies on the mechanism of platelet aggregation and release reaction induced by collagen and adrenaline. Thrombosis research, 1977, Volume: 11, Issue:2 Topics: Adenosine Diphosphate; Collagen; DEAE-Dextran; Dextrans; Epinephrine; Heparin; Hirudins; Humans; Platelet Aggregation	1977
Fibrin-induced release of platelet serotonin. The American journal of physiology, 1976, Volume: 231, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Calcium; Fibrin; Fibrinogen; Hirudins; Humans; Platelet Adhesiveness; Platelet Aggregation; Prostaglandins E; Serotonin; Thrombin	1976
ADP, thrombin, and Bothrops atrox thrombinlike enzyme in platelet-dependent fibrin retraction. The American journal of physiology, 1975, Volume: 229, Issue:3 Topics: Adenosine Diphosphate; Animals; Apyrase; Batroxobin; Blood Platelets; Clot Retraction; Collagen; Creatine Kinase; Epinephrine; Hirudins; Humans; Phosphocreatine; Snake Venoms; Snakes; Thrombin	1975
Hirudisins. Hirudin-derived thrombin inhibitors with disintegrin activity. The Journal of biological chemistry, 1992, Dec-05, Volume: 267, Issue:34 Topics: Adenosine Diphosphate; Amino Acid Sequence; Disintegrins; Hirudins; Humans; Kinetics; Mathematics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligopeptides; Peptide Fragments; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Protein Engineering; Prothrombin; Recombinant Proteins; Thrombin; Venoms	1992
The inhibition of platelet aggregation of metastatic H-ras-transformed 10T1/2 fibroblasts with castanospermine, an N-linked glycoprotein processing inhibitor. Cancer letters, 1991, Dec-01, Volume: 60, Issue:3 Topics: Adenosine Diphosphate; Animals; Apyrase; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Genes, ras; Glucosidases; Glycoproteins; Hirudins; Humans; In Vitro Techniques; Indolizines; Kinetics; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Transfection	1991
The effects of recombinant hirudin on various platelet functions. Haemostasis, 1991, Volume: 21 Suppl 1 Topics: Adenosine Diphosphate; Blood Platelets; Citrates; Citric Acid; Epinephrine; Heparin; Hirudins; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Recombinant Proteins	1991
Effect of recombinant hirudin on cytosolic Ca2+ concentrations using different platelet stimulators. Haemostasis, 1991, Volume: 21 Suppl 1 Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Chromatography, Gel; Collagen; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Hirudins; Humans; Ionomycin; Platelet Activating Factor; Platelet Aggregation; Recombinant Proteins; Second Messenger Systems; Thrombin	1991
Platelet aggregation in recombinant-hirudin-anticoagulated blood. Haemostasis, 1991, Volume: 21 Suppl 1 Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Citrates; Citric Acid; Collagen; Drug Synergism; Epinephrine; Hirudins; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Recombinant Proteins; Serotonin	1991
Inhibition of the thrombin-platelet reactions by DuP 714. Biochemical and biophysical research communications, 1991, Sep-30, Volume: 179, Issue:3 Topics: Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Boron Compounds; Collagen; Epinephrine; Fibrinogen; Hirudins; Humans; Kinetics; Oligopeptides; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombin	1991
Thrombin regulation of platelet interaction with damaged vessel wall and isolated collagen type I at arterial flow conditions in a porcine model: effects of hirudins, heparin, and calcium chelation. Blood, 1991, Jul-15, Volume: 78, Issue:2 Topics: Adenosine Diphosphate; Analysis of Variance; Animals; Aorta; Blood Platelets; Calcium; Citrates; Collagen; Heparin; Hirudins; Muscle, Smooth, Vascular; Perfusion; Platelet Aggregation; Recombinant Proteins; Swine; Thrombin	1991
Studies on platelet functions in hirudin plasma. Folia haematologica (Leipzig, Germany : 1928), 1988, Volume: 115, Issue:1-2 Topics: Adenosine Diphosphate; Blood Platelets; Calcium; Citrates; Collagen; Heparin; Hirudins; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Function Tests	1988
Evidence for tight metabolic control of the receptor-activated polyphosphoinositide cycle in human platelets. The Biochemical journal, 1989, Oct-15, Volume: 263, Issue:2 Topics: Adenosine Diphosphate; Blood Platelets; Creatine Kinase; Enzyme Activation; Epinephrine; Hirudins; Humans; Phosphatidic Acids; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphocreatine; Phosphorus Radioisotopes; Thrombin; Type C Phospholipases	1989
Mechanisms of platelet activation by cultured human cancer cells and cells freshly isolated from tumor tissues. Invasion & metastasis, 1989, Volume: 9, Issue:5 Topics: Adenosine Diphosphate; Adult; Apyrase; Blood Platelets; Breast Neoplasms; Cell Communication; Cell Separation; Colonic Neoplasms; Concanavalin A; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hirudins; Humans; Melanoma; Platelet Aggregation; Tumor Cells, Cultured	1989
Requirement for thrombin receptor occupancy during platelet secretion under aggregating and non-aggregating conditions. Thrombosis and haemostasis, 1987, Dec-18, Volume: 58, Issue:4 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Hirudins; Humans; Hydrolases; In Vitro Techniques; Platelet Aggregation; Receptors, Cell Surface; Receptors, Thrombin; Thrombin	1987
Fibrinogen-independent aggregation and deaggregation of human platelets: studies in two afibrinogenemic patients. Blood, 1987, Volume: 70, Issue:1 Topics: Adenosine Diphosphate; Adolescent; Adult; Afibrinogenemia; Antibodies; Chymotrypsin; Edetic Acid; Female; Fibrinogen; Hirudins; Humans; Immunoglobulin Fab Fragments; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombin	1987
Conditions affecting the responses of human platelets to epinephrine. Thrombosis and haemostasis, 1988, Oct-31, Volume: 60, Issue:2 Topics: Adenosine Diphosphate; Amino Acid Chloromethyl Ketones; Antithrombins; Blood Platelets; Calcium; Drug Synergism; Epinephrine; Hirudins; Humans; Microscopy, Electron, Scanning; Platelet Aggregation	1988
Plasma-dependent and -independent mechanisms of platelet aggregation induced by human tumour cell lines. Thrombosis research, 1987, Jun-01, Volume: 46, Issue:5 Topics: Adenosine Diphosphate; Adult; Apyrase; Blood Coagulation Tests; Calcium; Cell Communication; Cell Line; Colonic Neoplasms; Heparin; Hirudins; Humans; Plasma; Platelet Aggregation; Thrombin	1987
Adhesion of human breast cancer cell line MCF-7 to human vascular endothelial cells in culture. Enhancement by activated platelets. International journal of cancer, 1987, Oct-15, Volume: 40, Issue:4 Topics: Adenosine Diphosphate; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cells, Cultured; Endothelium, Vascular; Epinephrine; Extracellular Matrix; Female; Fibrinogen; Heparin; Hirudins; Humans; Microscopy, Electron; Microscopy, Electron, Scanning; Oligopeptides; Platelet Aggregation; Thrombin	1987
Analysis of the fate of platelet-bound thrombin. Archives of biochemistry and biophysics, 1985, Volume: 236, Issue:1 Topics: Adenosine Diphosphate; Autoradiography; Blood Platelets; Calcimycin; Electrophoresis, Polyacrylamide Gel; Hirudins; Humans; In Vitro Techniques; Protein Binding; Thrombin	1985
Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. Biochimica et biophysica acta, 1985, Jul-26, Volume: 841, Issue:1 Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chymotrypsin; Collagen; Fibrinogen; Heparin; Hirudins; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Thrombin; Viper Venoms	1985
Platelet interaction with polymerizing fibrin. The Journal of clinical investigation, 1972, Volume: 51, Issue:3 Topics: Adenine Nucleotides; Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Cell Aggregation; Chelating Agents; Edetic Acid; Fibrin; Fibrinogen; Hirudins; Humans; Iodine Isotopes; Isoflurophate; L-Lactate Dehydrogenase; Microscopy, Electron; Platelet Adhesiveness; Polymers; Prostaglandins; Rabbits; Serotonin; Swine; Thrombin; Tritium	1972
Tight coupling of thrombin-induced acid hydrolase secretion and phosphatidate synthesis to receptor occupancy in human platelets. The Biochemical journal, 1984, Aug-15, Volume: 222, Issue:1 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Antimetabolites; Blood Platelets; Dose-Response Relationship, Drug; Hirudins; Humans; Hydrolases; Phosphates; Phosphatidic Acids; Phosphatidylinositols; Receptors, Cell Surface; Receptors, Thrombin; Thrombin	1984
Thrombin-induced platelet responses differ in requirement for receptor occupancy. Evidence for tight coupling of occupancy and compartmentalized phosphatidic acid formation. The Journal of biological chemistry, 1981, Sep-25, Volume: 256, Issue:18 Topics: Acetylglucosaminidase; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcium; Hirudins; Humans; Kinetics; Phosphatidic Acids; Platelet Aggregation; Receptors, Cell Surface; Receptors, Thrombin; Serotonin; Thrombin	1981
Effect of an impermeant arginine-modifying reagent on the responses of rabbit platelets to agonists. Thrombosis and haemostasis, 1983, Jun-28, Volume: 49, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Aldehydes; Animals; Arginine; Binding, Competitive; Cell Membrane Permeability; Hirudins; Phentolamine; Phenylglyoxal; Platelet Aggregation; Rabbits; Receptors, Cell Surface; Receptors, Purinergic; Serotonin Antagonists; Thrombin	1983
Dependence of human platelet functional responses on divalent cations: aggregation and secretion in heparin- and hirudin-anticoagulated platelet-rich plasma and the effects of chelating agents. Thrombosis and haemostasis, 1981, Apr-30, Volume: 45, Issue:2 Topics: Adenosine Diphosphate; Anticoagulants; Blood Platelets; Calcium; Cations, Divalent; Chelating Agents; Citrates; Edetic Acid; Egtazic Acid; Epinephrine; Heparin; Hirudins; Humans; Magnesium; Platelet Aggregation	1981
The presence of platelet-activating factor (PAF) in normal human mixed saliva. Journal of immunology (Baltimore, Md. : 1950), 1981, Volume: 127, Issue:1 Topics: Adenosine Diphosphate; Adult; Animals; Arachidonic Acids; Creatine Kinase; Dose-Response Relationship, Immunologic; Female; Hirudins; Humans; Indomethacin; Lysophosphatidylcholines; Male; Middle Aged; Platelet Activating Factor; Rabbits; Saliva; Serotonin; Thrombin	1981
Differing platelet aggregating effects by two tumor cell lines: absence of role for platelet-derived ADP. American journal of hematology, 1981, Volume: 11, Issue:4 Topics: Adenosine Diphosphate; Animals; Apyrase; Blood Platelets; Cell Line; Cell Membrane; Glioma; Heparin; Hirudins; Humans; Membrane Proteins; Mice; Neoplasms, Experimental; Phospholipase D; Platelet Aggregation	1981
Characterization of the platelet-aggregating activity of tumor cells. Cancer research, 1980, Volume: 40, Issue:4 Topics: Adenocarcinoma; Adenosine Diphosphate; Animals; Aspirin; Cell Line; Cell Membrane; Growth Substances; Hirudins; In Vitro Techniques; Kidney Neoplasms; Magnesium; Mice; Neoplasms, Experimental; Neuroblastoma; Platelet Aggregation; Rabbits	1980
Adrenaline-induced reactions of human platelets in hirudin plasma. Haemostasis, 1980, Volume: 9, Issue:3 Topics: Adenosine Diphosphate; Calcium; Epinephrine; Hirudins; Humans; Platelet Aggregation; Platelet Function Tests	1980
Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators. The Biochemical journal, 1994, Oct-15, Volume: 303 ( Pt 2) Topics: Adenosine Diphosphate; Amino Acid Sequence; Arachidonic Acid; Aspirin; Blood Platelets; Cytoskeleton; Drug Interactions; GTP-Binding Proteins; Hirudins; Humans; Integrin alpha2; Membrane Glycoproteins; Molecular Sequence Data; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins pp60(c-src); Purinergic P2 Receptor Antagonists; Receptors, Thrombin; Signal Transduction; Thrombin	1994
Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood. Thrombosis and haemostasis, 1995, Volume: 73, Issue:2 Topics: Adenosine Diphosphate; Amino Acid Sequence; Hirudins; Humans; Iloprost; Magnesium Chloride; Molecular Sequence Data; Molsidomine; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Streptokinase; Thromboxane A2	1995
Transformed rat arterial smooth muscle cells induce platelet aggregation. Atherosclerosis, 1994, Volume: 110, Issue:2 Topics: Adenosine Diphosphate; Animals; Apyrase; Blood Coagulation; Cell Line, Transformed; Edetic Acid; Hirudins; Iodoacetates; Iodoacetic Acid; Muscle, Smooth, Vascular; Phospholipase D; Phospholipases A; Phospholipases A2; Platelet Aggregation; Rats	1994
ADP-, PAF- and adrenaline-induced platelet aggregation and thromboxane formation are not affected by a thromboxane receptor antagonist at physiological external Ca++ concentrations. Thrombosis research, 1994, Aug-01, Volume: 75, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Citric Acid; Collagen; Epinephrine; Glucose; Hirudins; Humans; Indomethacin; Phenylacetates; Platelet Activating Factor; Platelet Aggregation; Receptors, Thromboxane; Recombinant Proteins; Sulfonamides; Thromboxanes	1994
Ticlopidine facilitates the deaggregation of human platelets aggregated by thrombin. Thrombosis and haemostasis, 1994, Volume: 71, Issue:1 Topics: Adenosine Diphosphate; Aged; Alprostadil; Chymotrypsin; Female; Fibrinolysin; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Thrombin; Ticlopidine	1994
Effect of hirudin on platelet deposition to an artificial surface during low-stress shear flow of whole blood. Biomaterials, 1993, Volume: 14, Issue:11 Topics: Adenosine Diphosphate; Biocompatible Materials; Blood Flow Velocity; Hemolysis; Hirudins; Humans; Platelet Adhesiveness; Platelet Aggregation; Platelet Count; Polymers; Polytetrafluoroethylene; Viscosity	1993
Thrombopoietin primes human platelet aggregation induced by shear stress and by multiple agonists. Blood, 1996, Jun-01, Volume: 87, Issue:11 Topics: Adenosine Diphosphate; Blood Viscosity; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Synergism; Epinephrine; Fatty Acids, Unsaturated; Hematopoietic Cell Growth Factors; Hirudins; Humans; Hydrazines; Interleukins; Oligopeptides; Platelet Aggregation; Recombinant Proteins; Serotonin; Stress, Mechanical; Thrombin; Thrombopoietin; Vasopressins	1996
Platelet aggregation, sensitivity to prostaglandin E1 and thromboxane A2 release in recombinant hirudin- and heparin-anticoagulated blood. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1996, Volume: 7, Issue:2 Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Female; Gas Chromatography-Mass Spectrometry; Heparin; Hirudins; Humans; Male; Platelet Aggregation; Recombinant Proteins; Thromboxane A2	1996
Comparison of enoxaparin, hirulog, and heparin as adjunctive antithrombotic therapy during thrombolysis with rtPA in the stenosed canine coronary artery. Thrombosis and haemostasis, 1997, Volume: 78, Issue:4 Topics: Adenosine Diphosphate; Animals; Aspirin; Bleeding Time; Collagen; Coronary Thrombosis; Dogs; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Enoxaparin; Factor Xa Inhibitors; Female; Fibrinolytic Agents; Hemorrhage; Hemostasis; Heparin; Hirudin Therapy; Hirudins; Male; Partial Thromboplastin Time; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prothrombin; Prothrombin Time; Recombinant Proteins; Recurrence; Safety; Thrombin; Thrombolytic Therapy; Tissue Plasminogen Activator	1997
Platelet agonists enhance the import of phosphatidylethanolamine into human platelets. The Journal of biological chemistry, 1998, Oct-23, Volume: 273, Issue:43 Topics: Adenosine Diphosphate; Apolipoproteins B; Arachidonic Acid; Arginine; Biological Transport; Blood Coagulation; Blood Platelets; Collagen; Dansyl Compounds; Hirudins; Humans; Lipoproteins, LDL; Peptide Fragments; Phosphatidylethanolamines; Phospholipids; Platelet Activation; Protein Kinase C	1998
Differential effects of three radiographic contrast media on platelet aggregation and degranulation: implications for clinical practice? British journal of haematology, 1998, Volume: 103, Issue:4 Topics: Adenosine Diphosphate; Antithrombins; Aspirin; Cell Degranulation; Contrast Media; Hirudins; Humans; Iopamidol; Ioxaglic Acid; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Triiodobenzoic Acids	1998
Streptokinase-induced platelet activation involves antistreptokinase antibodies and cleavage of protease-activated receptor-1. Blood, 2000, Feb-15, Volume: 95, Issue:4 Topics: Adenosine Diphosphate; Amino Acid Sequence; Antibodies; Antibodies, Bacterial; Blood Platelets; Calcium; Hirudins; Humans; In Vitro Techniques; Leukemia, Erythroblastic, Acute; Molecular Sequence Data; Peptide Fragments; Platelet Activation; Platelet Aggregation; Receptor, PAR-1; Receptors, Fc; Receptors, Thrombin; Streptokinase; Tumor Cells, Cultured	2000
Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation. Platelets, 2001, Volume: 12, Issue:2 Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Clopidogrel; Epinephrine; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Hirudins; Humans; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Receptor Agonists; Ticlopidine	2001
Decreased platelet reactivity in blood anticoagulated with bivalirudin or enoxaparin compared with unfractionated heparin: implications for coronary intervention. Journal of thrombosis and thrombolysis, 2002, Volume: 13, Issue:3 Topics: Adenosine Diphosphate; Aged; Anticoagulants; Coronary Artery Disease; Drug Evaluation; Enoxaparin; Flow Cytometry; Heparin; Hirudins; Humans; Middle Aged; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins	2002
Effects of inhibition of P2Y(1) and P2Y(12) on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry. Thrombosis research, 2003, Mar-15, Volume: 109, Issue:5-6 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Blood Coagulation; Carrier Proteins; Elasticity; Fibrinolysis; Flow Cytometry; Hemorheology; Hirudins; Humans; Membrane Proteins; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Recombinant Proteins; Tissue Plasminogen Activator; Whole Blood Coagulation Time	2003
Mechanisms involved in adenosine triphosphate--induced platelet aggregation in whole blood. Arteriosclerosis, thrombosis, and vascular biology, 2003, Oct-01, Volume: 23, Issue:10 Topics: Adenosine Deaminase; Adenosine Diphosphate; Adenosine Triphosphate; Anticoagulants; Dipyridamole; Hirudins; Humans; Leukocytes; Plasma; Platelet Aggregation	2003
Soluble fibrin is the main mediator of Staphylococcus aureus adhesion to platelets. Circulation, 2004, Jul-13, Volume: 110, Issue:2 Topics: Adenosine Diphosphate; Ancrod; Animals; Bacterial Adhesion; Blood Platelet Disorders; Blood Platelets; Coagulase; Cytoplasmic Granules; Fibrin; Fibrinogen; Hirudins; Humans; Mice; Mice, Knockout; Oligopeptides; Platelet Activation; Protein Binding; Staphylococcus aureus; Thrombin; Thrombospondin 1	2004
Effects of anticoagulants used during blood collection on human platelet function. Methods in molecular biology (Clifton, N.J.), 2004, Volume: 272 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Anticoagulants; Blood Platelets; Citric Acid; Female; Heparin; Hirudins; Humans; Membrane Proteins; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Pregnancy; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Time Factors	2004
The influence of platelets on the promotion of invasion by tumor cells and inhibition by antiplatelet agents. Pancreas, 2004, Volume: 29, Issue:2 Topics: Adenocarcinoma; Adenosine Diphosphate; Adult; Blood Platelets; Cell Line, Tumor; Cilostazol; Collagen; Drug Combinations; Drug Screening Assays, Antitumor; Eicosapentaenoic Acid; Epoprostenol; Hirudins; Humans; Laminin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Proteins; Pancreatic Neoplasms; Platelet Activation; Platelet Aggregation Inhibitors; Proteoglycans; Tetrazoles; Thrombin	2004
Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin. Thrombosis research, 2005, Volume: 115, Issue:4 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Degranulation; Dalteparin; Drug Synergism; Heparin; Hirudins; Humans; In Vitro Techniques; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12	2005
Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thrombosis and haemostasis, 2006, Volume: 96, Issue:6 Topics: Adenosine Diphosphate; Anticoagulants; Apyrase; Aspirin; Blood Preservation; Citrates; Collagen; Dose-Response Relationship, Drug; Electric Impedance; Electrodes; Hirudins; Humans; In Vitro Techniques; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Sodium Citrate; Time Factors	2006
Critical temperature ranges of hypothermia-induced platelet activation: possible implications for cooling patients in cardiac surgery. Thrombosis and haemostasis, 2007, Volume: 97, Issue:4 Topics: Adenosine Diphosphate; Adult; Anticoagulants; Blood Platelets; Cardiac Surgical Procedures; Collagen; Crotalid Venoms; Female; Flow Cytometry; Heparin; Hirudins; Humans; Hypothermia, Induced; In Vitro Techniques; Lectins, C-Type; Logistic Models; Male; Middle Aged; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Research Design; Risk Factors; Temperature; Thromboembolism; Transport Vesicles	2007
Enhanced platelet aggregation and activation under conditions of hypothermia. Thrombosis and haemostasis, 2007, Volume: 98, Issue:6 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Blood Specimen Collection; Citrates; Cold Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hirudins; Humans; Hypothermia, Induced; In Vitro Techniques; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Membrane Glycoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Tetraspanin 30; Time Factors	2007
Multiple electrode aggregometry and P2Y(12) antagonists. Thrombosis and haemostasis, 2008, Volume: 99, Issue:6 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Clopidogrel; Dose-Response Relationship, Drug; Electrodes; Equipment Design; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine	2008
Lack of early augmentation of platelet reactivity after coronary intervention in patients treated with bivalirudin. Journal of thrombosis and thrombolysis, 2009, Volume: 28, Issue:1 Topics: Adenosine Diphosphate; Angina Pectoris; Anticoagulants; Aspirin; Cardiac Catheterization; Clopidogrel; Elective Surgical Procedures; Hemostatics; Hirudins; Humans; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Postoperative Period; Recombinant Proteins; Thrombin; Ticlopidine; Time Factors	2009
The effect of ex vivo anticoagulants on whole blood platelet aggregation. Platelets, 2009, Volume: 20, Issue:1 Topics: Adenosine Diphosphate; Anticoagulants; Arachidonic Acid; Arginine; Azetidines; Benzylamines; Blood Platelets; Citric Acid; Collagen; Female; Heparin; Hirudins; Humans; Male; Peptide Fragments; Pipecolic Acids; Platelet Aggregation; Platelet Function Tests; Recombinant Proteins; Ristocetin; Sulfonamides; Time Factors	2009
Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. Coronary artery disease, 2009, Volume: 20, Issue:2 Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Clinical Trials as Topic; Coronary Artery Disease; Crotalid Venoms; Drug Evaluation, Preclinical; Drug Therapy, Combination; Eptifibatide; Fibrinolytic Agents; Flow Cytometry; Heparin; Hirudins; Humans; Lectins, C-Type; P-Selectin; Peptide Fragments; Peptides; Pilot Projects; Platelet Activating Factor; Platelet Activation; Platelet Function Tests; Recombinant Proteins; Research Design; Thrombin	2009
Measurement of platelet function in dogs using a novel impedance aggregometer. Veterinary journal (London, England : 1997), 2010, Volume: 185, Issue:2 Topics: Adenosine Diphosphate; Animals; Anticoagulants; Arachidonic Acid; Blood Platelets; Citric Acid; Collagen; Dogs; Electric Impedance; Female; Hirudins; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Reference Values; Reproducibility of Results; Sensitivity and Specificity	2010
Measurement of platelet aggregation in ovine blood using a new impedance aggregometer. Veterinary clinical pathology, 2010, Volume: 39, Issue:2 Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Collagen; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Hirudins; Male; Platelet Aggregation; Platelet Function Tests; Receptors, Thrombin; Reference Values; Ristocetin; Sheep	2010
The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood. Thrombosis and haemostasis, 2010, Volume: 103, Issue:6 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Cells, Cultured; Citrates; Collagen; Dinoprostone; Drug Synergism; Hirudins; Humans; Inflammation; Platelet Aggregation; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Vasoconstrictor Agents	2010
Platelet function testing in hirudin and BAPA anticoagulated blood. Clinical chemistry and laboratory medicine, 2011, Volume: 49, Issue:3 Topics: Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Blood Platelets; Dipeptides; Female; Hirudins; Humans; Male; Platelet Aggregation Inhibitors; Platelet Function Tests; Sensitivity and Specificity; Sulfonamides	2011
Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. PloS one, 2011, Apr-15, Volume: 6, Issue:4 Topics: Adenosine Diphosphate; Anaphylatoxins; Blood Platelets; Calcimycin; Collagen; Complement Membrane Attack Complex; Crotalid Venoms; Hirudins; Humans; Kinetics; Lectins, C-Type; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet-Rich Plasma; Protein Binding; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, Thrombin; Signal Transduction; Solubility	2011
Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: a comparison between citrate and hirudin. Platelets, 2013, Volume: 24, Issue:5 Topics: Adenosine Diphosphate; Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Anticoagulants; Arachidonic Acid; Aspirin; Citric Acid; Clopidogrel; Female; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; ROC Curve; Sensitivity and Specificity; Stents; Ticlopidine	2013
Expression, purification, and mass spectrometric analysis of 15N, 13C-labeled RGD-hirudin, expressed in Pichia pastoris, for NMR studies. PloS one, 2012, Volume: 7, Issue:8 Topics: Adenosine Diphosphate; Antithrombins; Carbon Isotopes; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Hirudins; Humans; Hydrogen-Ion Concentration; Isotope Labeling; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; Nitrogen Isotopes; Pichia; Platelet Aggregation; Temperature	2012
Sampling conditions influence multiple electrode platelet aggregometry in cardiac surgery patients. Scandinavian cardiovascular journal : SCJ, 2013, Volume: 47, Issue:2 Topics: Adenosine Diphosphate; Aged; Anticoagulants; Blood Specimen Collection; Citric Acid; Coronary Artery Bypass; Electrodes; Female; Fibrinolytic Agents; Hemostatics; Heparin; Heparin Antagonists; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Postoperative Care; Postoperative Hemorrhage; Predictive Value of Tests; Preoperative Care; Prospective Studies; Protamines; Sensitivity and Specificity; Thrombin; Time Factors	2013
Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans. Journal of neurotrauma, 2014, Feb-15, Volume: 31, Issue:4 Topics: Acute Disease; Adenosine Diphosphate; Animals; Blood Cell Count; Blood Coagulation Disorders; Blood Platelets; Brain; Brain Injuries; Hirudins; Kinetics; Male; Partial Thromboplastin Time; Platelet Aggregation; Prothrombin; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Subarachnoid Hemorrhage; Thrombelastography; Thrombin; Wounds, Nonpenetrating	2014
Whole blood platelet aggregation determined by the ROTEM platelet equipment; reference intervals and stability. Platelets, 2020, Volume: 31, Issue:2 Topics: Adenosine Diphosphate; Adult; Aged; Anticoagulants; Arachidonic Acid; Citric Acid; Female; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Function Tests; Receptors, Thrombin; Reference Values; Reproducibility of Results; Young Adult	2020