Compounds > adenosine diphosphate
Page last updated: 2024-08-17

adenosine diphosphate and cangrelor

adenosine diphosphate has been researched along with cangrelor in 80 studies

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's56 (70.00)29.6817
2010's20 (25.00)24.3611
2020's4 (5.00)2.80

Authors

AuthorsStudies
Jacobson, KA; Jarvis, MF; Williams, M1
Boeynaems, JM; Communi, D; Gonzalez, NS; Labouret, C; Le Poul, E; Marteau, F; Savi, P1
Hayakawa, T; Ishii-Watabe, A; Mizuguchi, H; Uchida, E1
Heemskerk, JW; Sage, SO; Yamoah, EH1
Driscoll, EM; Gonzales, ML; Huang, J; Lucchesi, BR; Park, AM1
Cameron, KE; Heptinstall, S; May, JA; Sanderson, HM; Storey, RF; White, AE1
Gear, AR; Suttitanamongkol, S1
Honda, S; Imai, Y; Inoue, K; Kohsaka, S; Nakamura, Y; Ohsawa, K; Sasaki, Y1
Maayani, S; Martinez, R; Schwarz, T; Tagliente, TM1
Bath, P; Heptinstall, S; Zhao, L1
McIntire, LV; Moake, JL; Turner, NA1
Guile, SD; Ince, F; Ingall, AH; Kindon, ND; Meghani, P; Mortimore, MP1
Balduini, C; Lova, P; Paganini, S; Sinigaglia, F; Torti, M1
de Groot, PG; IJsseldijk, MJ; Jeninga, EH; Nurden, AT; Nurden, P; Remijn, JA; Sixma, JJ; van Willigen, G; Wu, YP1
Eto, K; Goto, S; Handa, S; Ikeda, Y; Tamura, N1
Heptinstall, S; Judge, HM; Storey, RF; Wilcox, RG1
Balduini, C; Barberis, L; Hirsch, E; Lova, P; Paganini, S; Sinigaglia, F; Torti, M; Wymann, M1
Heptinstall, S; Storey, RF; Wilcox, RG1
Nurden, AT; Nurden, P1
Lindahl, TL; Ramström, S; Rånby, M1
Cazenave, JP; Freund, M; Gachet, C; Leon, C; Ravanat, C1
Behan, MW; Fox, SC; Heptinstall, S1
Bryckaert, M; Habib, A; Jandrot-Perrus, M; Pawlowski, M; Roger, S; Rosa, JP1
Slegers, H; Van Kolen, K1
Graff, J; Harder, S; Klinkhardt, U1
Ishisaki, A; Kitajima, Y; Kozawa, O; Matsuno, H; Tokuda, H; Zhou, Y1
Aleil, B; Cazenave, JP; Gachet, C; Heitz, A; Ravanat, C; Rochoux, G1
Heptinstall, S; May, JA; Storey, RF1
Humphries, RG; van Giezen, JJ1
Fälker, K; Lange, D; Presek, P1
Gerevich, Z; Illes, P; Müller, C1
Barbaras, R; Boeynaems, JM; Champagne, E; Collet, X; Gachet, C; Jacquet, S; Malaval, C; Martinez, LO; Nauze, M; Perez, C; Perret, B; Rolland, C; Sak, K; Tercé, F1
Hardy, AR; Hill, DJ; Poole, AW1
Johansson, K; Lindahl, TL; Nylander, S; Van Giezen, JJ1
Kamae, T; Kanakura, Y; Kashiwagi, H; Kato, H; Kurata, Y; Shiraga, M; Tadokoro, S; Tomiyama, Y1
Harrison, P; Pidcock, M1
Cerletti, C; de Gaetano, G; Pampuch, A1
Cattaneo, M; Lecchi, A1
Brandl, R; Deckmyn, H; Penz, SM; Reininger, AJ; Siess, W; Toth, O1
Akers, WS; Charnigo, R; Ferraris, S; Oestreich, JH; Oh, JJ; Steinhubl, SR1
Holmes, CE; Madsen, NJ; Schneider, DJ; Serrano, FA; Sobel, BE1
Fox, SC; Heptinstall, S; White, AE; Wilcox, RG; Xavier, RG1
Inoue, K; Irino, Y; Kohsaka, S; Nakamura, Y; Ohsawa, K1
Dovlatova, NL; Fox, SC; Glenn, JR; Heptinstall, S; Manolopoulos, P; May, JA; Ralevic, V; Tang, SW; Thomas, NR1
Dovlatova, NL; Heptinstall, S; Jakubowski, JA; Sugidachi, A1
Dovlatova, N; Heptinstall, S; Johnson, A1
Abbracchio, MP; Fantucci, P; Parravicini, C; Ranghino, G1
Dovlatova, N; Fox, SC; Heptinstall, S; Johnson, AJ; Latif, ML; Manolopoulos, P; Ralevic, V; White, AE; Wijeyeratne, YD1
Di Pasquale, F; Hoffmann, K; Sixel, U; von Kügelgen, I1
Barbaras, R; Champagne, E; Collet, X; Laffargue, M; Malaval, C; Martinez, LO; Peres, C; Perret, B; Rolland, C; Tercé, F1
Béres, BJ; Kerecsen, G; Kiss, RG; László, A; Masszi, T; Préda, I; Tóth-Zsámboki, E; Vargová, K1
Schneider, DJ; Sobel, BE1
Bhavaraju, K; Bynagari, YS; Kim, S; Kunapuli, SP; Nagy, B; Tuluc, F; Vijayan, KV1
Huang, JS; Khasawneh, FT; Lam, SC; Le Breton, GC; Mir, F; Srinivasan, S1
Fox, SC; Heptinstall, S; May, JA; Neubert, U; Shah, A1
del Río, A; Heras, M1
Brunner, KP; Kobsar, AL; Koessler, J; Rajkovic, MS; Steigerwald, U; Walter, U1
Bushell, TJ; Kennedy, C; Parmar, M; Shrestha, SS1
Ashby, B; Jin, J; Kunapuli, SP; Mao, Y; Zhang, L1
Fox, SC; Glenn, JR; Heptinstall, S; Iyú, D; White, AE1
Cattaneo, M1
Boehm, S; Klinger, F; Schicker, K; Yousuf, A1
Berndt, M; Canney, A; Conlon, N; Crowley, D; Ducrée, J; Dunne, E; Egan, K; Ffrench, B; Finn, S; Gallagher, M; Keegan, H; Kenny, D; Laios, A; Martin, C; McEneaney, V; McEvoy, L; Norris, L; O'Leary, J; O'Toole, S; Sheils, O; Smith, L; Smyth, P; Spillane, C; Stordal, B1
Balkau, B; Greiner, TO; Krajewski, S; Kurz, J; Neumann, B; Peter, K; Stolz, A; Straub, A; Unertl, K; Wendel, HP1
Gartner, TK; Li, Z; Morris, AJ; Ren, H; Smyth, SS; Sunkara, M; Xiang, B; Zhang, G1
Brass, LF; Cermignano, SL; Diamond, SL; Stalker, TJ; Traxler, EA; Voronov, R; Wannemacher, KM; Wu, J1
Beck, F; Buhs, S; Geiger, J; Gerull, H; Nollau, P; Schweigel, H; Sickmann, A; Walter, U1
Kassassir, H; Siewiera, K; Sychowski, R; Watała, C1
Bune, LT; Kylhammar, D; Rådegran, G1
Grenegård, M; Lindström, EG; Öllinger, K; Ramström, S; Södergren, AL; Svensson Holm, AC1
Frelinger, AL; Gremmel, T; Michelson, AD; Przyklenk, K; Undyala, VV; Wider, J; Wright, GE; Yanachkov, IB; Yanachkova, MI1
Blazejczyk, A; Kalchenko, V; Przygodzki, T; Talar, M; Watala, C1
Cinalli, AR; Fernández, V; Guarracino, JF; Losavio, AS; Roquel, LI1
Lambertucci, C; Volpini, R; Zhang, W; Zhou, S; Zhuo, T1
Ferenc, M; Hochholzer, W; Löffelhardt, N; Mashayekhi, K; Neumann, FJ; Nührenberg, T; Stratz, C; Trenk, D; Valina, CM1
Arai, N; Enomoto, Y; Ishida, H; Kitano, K; Komiyama, Y; Omori, Y; Sakayori, T; Uematsu, K; Watanabe, Y1
Baillie, JK; Chan, MV; Dru, RC; Graham, CJ; Lee, EW; Paterson, GG; Thompson, AAR; Torpey, GS; Walmsley, SR; Warner, TD; Willson, JA; Young, JM1
Ishigaku, Y; Itabashi, R; Kamada, A; Maeda, T; Narumi, S; Natori, T; Oi, K; Oura, K; Shimizu, M; Terayama, Y; Tsuda, K; Yoshida, M1
Fan, D; Li, Q; Ma, LJ; Mao, YH; Tian, Z; Wan, JB; Ya, F; Yang, Y; Zhao, M; Zhao, Y; Zuo, X1
Bogoutdinova, A; Gambaryan, S; Kharazova, A; Mindukshev, I; Rukoyatkina, N; Shpakova, V1

Reviews

6 review(s) available for adenosine diphosphate and cangrelor

ArticleYear
Purine and pyrimidine (P2) receptors as drug targets.
    Journal of medicinal chemistry, 2002, Sep-12, Volume: 45, Issue:19

    Topics: Adenosine Triphosphate; Animals; Drug Design; Humans; Ligands; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Uridine Triphosphate

2002
The medicinal chemistry of the P2 receptor family.
    Progress in medicinal chemistry, 2001, Volume: 38

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Arteriosclerosis; Cloning, Molecular; Clopidogrel; Cystic Fibrosis; Humans; Ophthalmic Solutions; Polyphosphates; Receptors, Purinergic P2; Structure-Activity Relationship; Ticlopidine; Tissue Distribution; Uracil Nucleotides

2001
Advantages of fast-acting ADP receptor blockade in ischemic heart disease.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Feb-01, Volume: 23, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Drug Combinations; Humans; Myocardial Ischemia; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Thrombosis; Tissue Plasminogen Activator

2003
Preclinical and clinical studies with selective reversible direct P2Y12 antagonists.
    Seminars in thrombosis and hemostasis, 2005, Volume: 31, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Administration, Oral; Animals; Arterial Occlusive Diseases; Clinical Trials as Topic; Dogs; Double-Blind Method; Drug Evaluation, Preclinical; Female; Fibrinolytic Agents; Humans; Injections, Intravenous; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridines; Rabbits; Randomized Controlled Trials as Topic; Receptors, Purinergic P2Y12; Thrombosis; Ticagrelor

2005
Update on antiplatelet therapy in acute coronary syndromes: what do new drugs bring into clinical practice?
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2009, Volume: 9 Suppl 1

    Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Clopidogrel; Humans; Lactones; Piperazines; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Prasugrel Hydrochloride; Pyridines; Thiophenes; Ticagrelor; Ticlopidine

2009
Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate.
    Thrombosis and haemostasis, 2011, Volume: 105 Suppl 1

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Clinical Trials, Phase III as Topic; Clopidogrel; Hemorrhage; Humans; Piperazines; Platelet Activation; Prasugrel Hydrochloride; Quinazolinones; Receptors, Purinergic P2Y12; Sulfonamides; Thiophenes; Ticagrelor; Ticlopidine

2011

Trials

3 trial(s) available for adenosine diphosphate and cangrelor

ArticleYear
Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease.
    Platelets, 2002, Volume: 13, Issue:7

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Ticlopidine

2002
Transitioning patients from cangrelor to clopidogrel: pharmacodynamic evidence of a competitive effect.
    Thrombosis research, 2008, Volume: 121, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adolescent; Adult; Clopidogrel; Cyclooxygenase Inhibitors; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine

2008
Impact of Reticulated Platelets on the Antiplatelet Effect of the Intravenous P2Y12-Receptor Inhibitor Cangrelor.
    Thrombosis and haemostasis, 2018, Volume: 118, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Administration, Oral; Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Female; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Platelet Count; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thienopyridines; Ticagrelor

2018

Other Studies

71 other study(ies) available for adenosine diphosphate and cangrelor

ArticleYear
Pharmacological characterization of the human P2Y13 receptor.
    Molecular pharmacology, 2003, Volume: 64, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Kinetics; Receptors, Purinergic P2; Thionucleotides

2003
On the mechanism of plasmin-induced platelet aggregation. Implications of the dual role of granule ADP.
    Biochemical pharmacology, 2000, Jun-01, Volume: 59, Issue:11

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Apyrase; Blood Platelets; Calcium; Cell Degranulation; Drug Interactions; Epinephrine; Fibrinolysin; Fibrinolytic Agents; Humans; In Vitro Techniques; Ligands; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12

2000
The roles of P(2X1)and P(2T AC)receptors in ADP-evoked calcium signalling in human platelets.
    Cell calcium, 2000, Volume: 28, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Blood Platelets; Calcium Signaling; Humans; Membrane Proteins; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y12

2000
Prevention of arterial thrombosis by intravenously administered platelet P2T receptor antagonist AR-C69931MX in a canine model.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Arterial Occlusive Diseases; Bleeding Time; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Carotid Artery Thrombosis; Disease Models, Animal; Dogs; Female; Hemodynamics; Injections, Intravenous; Male; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Tunica Intima

2000
The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity.
    British journal of haematology, 2000, Volume: 110, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Annexin A5; Aspirin; Blood Platelets; Calcium; Collagen; Cytosol; Fibrinolytic Agents; Flow Cytometry; Humans; Membrane Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Stimulation, Chemical; Thromboxane A2

2000
ADP receptor antagonists inhibit platelet aggregation induced by the chemokines SDF-1, MDC and TARC.
    FEBS letters, 2001, Feb-09, Volume: 490, Issue:1-2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Chemokine CCL17; Chemokine CCL22; Chemokine CXCL12; Chemokines, CC; Chemokines, CXC; Dose-Response Relationship, Drug; GTP-Binding Proteins; Humans; Inhibitory Concentration 50; Pertussis Toxin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Thrombin; Time Factors; Virulence Factors, Bordetella

2001
Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Mar-15, Volume: 21, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Membrane; Cells, Cultured; Chemotaxis; Diffusion Chambers, Culture; Extracellular Space; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Microglia; Pertussis Toxin; rac GTP-Binding Proteins; Rats; Rats, Wistar; Receptors, Purinergic P2; Virulence Factors, Bordetella

2001
Activation of Gi-coupled receptors releases a tonic state of inhibited platelet aggregation.
    Platelets, 2001, Volume: 12, Issue:2

    Topics: Adaptation, Physiological; Adenosine Diphosphate; Adenosine Monophosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Clopidogrel; Epinephrine; Female; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Hirudins; Humans; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Receptor, Serotonin, 5-HT2A; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Receptors, Serotonin; Recombinant Proteins; Serotonin; Serotonin Receptor Agonists; Ticlopidine

2001
Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro.
    British journal of pharmacology, 2001, Volume: 134, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Communication; Dipyridamole; Drug Synergism; Flow Cytometry; Humans; Leukocytes; Macrophage-1 Antigen; Monocytes; Neutrophils; P-Selectin; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors

2001
Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow.
    Blood, 2001, Dec-01, Volume: 98, Issue:12

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Viscosity; Collagen Type I; Flow Cytometry; Hemorheology; Humans; Image Processing, Computer-Assisted; Membrane Proteins; Microscopy, Fluorescence; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12

2001
A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets.
    The Journal of biological chemistry, 2002, Apr-05, Volume: 277, Issue:14

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Antigens, CD; Blood Platelets; Calcium; Chromatography, Gel; Cross-Linking Reagents; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Platelet Aggregation Inhibitors; Protein Binding; rap GTP-Binding Proteins; Receptors, IgG; Recombinant Proteins; Serotonin; Signal Transduction; Time Factors

2002
Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Apr-01, Volume: 22, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aged; Analysis of Variance; Blood Platelets; Humans; Male; Membrane Proteins; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thrombosis

2002
Functional significance of adenosine 5'-diphosphate receptor (P2Y(12)) in platelet activation initiated by binding of von Willebrand factor to platelet GP Ibalpha induced by conditions of high shear rate.
    Circulation, 2002, May-28, Volume: 105, Issue:21

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Cell Adhesion; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Membrane Proteins; Microscopy, Fluorescence; Microscopy, Video; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stress, Mechanical; von Willebrand Factor

2002
Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin.
    Thrombosis and haemostasis, 2002, Volume: 88, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Adhesion; Clopidogrel; Drug Therapy, Combination; Female; Humans; Leukocytes; Male; Membrane Proteins; Middle Aged; Myocardial Ischemia; P-Selectin; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Stents; Ticlopidine

2002
A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.
    The Journal of biological chemistry, 2003, Jan-03, Volume: 278, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic Agonists; Androstadienes; Animals; Antimetabolites; Apyrase; Blood Platelets; Chromones; Dideoxyadenosine; Enzyme Inhibitors; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Mice; Mice, Knockout; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Platelet Activation; Platelet Aggregation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rap GTP-Binding Proteins; Receptors, Fc; Receptors, IgG; Second Messenger Systems; Wortmannin

2003
Effects of inhibition of P2Y(1) and P2Y(12) on whole blood clotting, coagulum elasticity and fibrinolysis resistance studied with free oscillation rheometry.
    Thrombosis research, 2003, Mar-15, Volume: 109, Issue:5-6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Blood Coagulation; Carrier Proteins; Elasticity; Fibrinolysis; Flow Cytometry; Hemorheology; Hirudins; Humans; Membrane Proteins; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Recombinant Proteins; Tissue Plasminogen Activator; Whole Blood Coagulation Time

2003
Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Oct-01, Volume: 23, Issue:10

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Disease Models, Animal; Humans; Leukocytes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; P-Selectin; Peptide Fragments; Phosphatidylserines; Plasma; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombin; Thrombosis

2003
Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1.
    Cell calcium, 2004, Volume: 35, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Alprostadil; Calcium; Calcium Signaling; Clopidogrel; Cytoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors

2004
Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.
    FEBS letters, 2004, Jan-02, Volume: 556, Issue:1-3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Cattle; Collagen; Enzyme Activation; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Integrin alpha2beta1; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2

2004
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
    Journal of neurochemistry, 2004, Volume: 89, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Animals; Cell Differentiation; Cell Division; Cell Line, Tumor; Cyclic AMP; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Adrenergic, beta; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides

2004
Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators.
    Thrombosis research, 2004, Volume: 113, Issue:5

    Topics: Abciximab; Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Aspirin; Blood Platelets; Cell Degranulation; Collagen; Drug Interactions; Humans; Immunoglobulin Fab Fragments; Membrane Proteins; Oligopeptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12

2004
P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetes.
    The Journal of clinical endocrinology and metabolism, 2005, Volume: 90, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aged; Diabetes Mellitus, Type 2; Female; Humans; Male; Membrane Proteins; Middle Aged; Piperazines; Piperidines; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reference Values

2005
Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases.
    Journal of thrombosis and haemostasis : JTH, 2005, Volume: 3, Issue:1

    Topics: Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adult; Aged; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Dose-Response Relationship, Drug; Drug Resistance; Female; Flow Cytometry; Humans; Male; Membrane Proteins; Microfilament Proteins; Middle Aged; Myocardial Ischemia; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors

2005
Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin.
    Thrombosis research, 2005, Volume: 115, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Blood Platelets; Cell Degranulation; Dalteparin; Drug Synergism; Heparin; Hirudins; Humans; In Vitro Techniques; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12

2005
P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets.
    Thrombosis and haemostasis, 2005, Volume: 93, Issue:5

    Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclases; Aspirin; Blood Platelets; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epinephrine; Epoprostenol; Humans; Membrane Proteins; Oligopeptides; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Thrombin; Time Factors; Tyrosine

2005
Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons.
    European journal of pharmacology, 2005, Oct-03, Volume: 521, Issue:1-3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Receptors, Purinergic P2Y1; Thionucleotides

2005
The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis.
    Cellular and molecular life sciences : CMLS, 2005, Volume: 62, Issue:21

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Endocytosis; Humans; Lipoproteins, HDL; Liver; Male; Mice; Mice, Inbred C57BL; Perfusion; Receptors, Purinergic P2

2005
Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism.
    Platelets, 2005, Volume: 16, Issue:7

    Topics: Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Androstadienes; Blood Platelets; Calcium; Cell Shape; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myosins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activation; Protein Serine-Threonine Kinases; Pseudopodia; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; rho-Associated Kinases; Second Messenger Systems; Wortmannin

2005
Evaluation of platelet function, a method comparison.
    Platelets, 2006, Volume: 17, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Dose-Response Relationship, Drug; Drug Monitoring; Humans; Platelet Activation; Platelet Aggregation; Platelet Count; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Fibrinogen; Reference Values; Regression Analysis; Sensitivity and Specificity; Time Factors

2006
Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation.
    Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Blood Platelets; Dose-Response Relationship, Drug; Humans; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Purinergic P2 Receptor Antagonists; rap GTP-Binding Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thrombin

2006
Can the PFA-100 be modified to detect P2Y12 inhibition?
    Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Clopidogrel; Drug Monitoring; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Ticlopidine

2006
Comparison of VASP-phosphorylation assay to light-transmission aggregometry in assessing inhibition of the platelet ADP P2Y12 receptor.
    Thrombosis and haemostasis, 2006, Volume: 96, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; In Vitro Techniques; Light; Male; Microfilament Proteins; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Reproducibility of Results

2006
Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin.
    Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclases; Blood Platelets; Cyclic AMP; Cyclic CMP; Deoxyadenine Nucleotides; Dose-Response Relationship, Drug; Drug Synergism; Epoprostenol; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Thrombin

2007
Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques.
    Thrombosis and haemostasis, 2007, Volume: 97, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Aspirin; Atherosclerosis; Blood Coagulation Tests; Blood Platelets; Carotid Stenosis; Dose-Response Relationship, Drug; Hemorheology; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thrombosis; Time Factors; von Willebrand Factor

2007
Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents.
    The American journal of cardiology, 2007, Aug-15, Volume: 100, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Benzothiazoles; Blood Platelets; Coronary Disease; Crotalid Venoms; Flow Cytometry; Fluorescent Dyes; Hemostatics; Humans; Lectins, C-Type; Platelet Activating Factor; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Count; Platelet Glycoprotein GPIIb-IIIa Complex; Quinolines; Thrombin; Tirofiban; Tyrosine

2007
Enhanced platelet aggregation and activation under conditions of hypothermia.
    Thrombosis and haemostasis, 2007, Volume: 98, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Blood Specimen Collection; Citrates; Cold Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hirudins; Humans; Hypothermia, Induced; In Vitro Techniques; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Membrane Glycoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Tetraspanin 30; Time Factors

2007
Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia.
    Journal of neuroscience research, 2008, May-15, Volume: 86, Issue:7

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Cells, Cultured; Cerebral Cortex; Chemotaxis; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Membrane Proteins; Microglia; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Type C Phospholipases

2008
Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents.
    Platelets, 2008, Volume: 19, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Calcium; Cell Adhesion Molecules; Cell Shape; Coenzyme A; Fibrinolytic Agents; Humans; Microfilament Proteins; Palmitoyl Coenzyme A; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12

2008
The reversible P2Y antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function.
    Journal of thrombosis and haemostasis : JTH, 2008, Volume: 6, Issue:7

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cells, Cultured; Clopidogrel; Drug Interactions; Humans; Piperazines; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine

2008
Multiple electrode aggregometry and P2Y(12) antagonists.
    Thrombosis and haemostasis, 2008, Volume: 99, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Clopidogrel; Dose-Response Relationship, Drug; Electrodes; Equipment Design; Hirudins; Humans; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Thiophenes; Ticlopidine

2008
GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.
    BMC bioinformatics, 2008, Jun-04, Volume: 9

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Binding Sites; Computer Simulation; Crystallography, X-Ray; Humans; Models, Molecular; Purinergic P2 Receptor Antagonists; Rats; Receptors, G-Protein-Coupled; Receptors, Purinergic P2; Structural Homology, Protein; Uridine Diphosphate

2008
Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor.
    Thrombosis and haemostasis, 2008, Volume: 100, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Cell Adhesion Molecules; Dinoprostone; Humans; Immunoblotting; Microfilament Proteins; Microscopy, Confocal; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Count; Purinergic P2 Receptor Agonists; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Purinergic P2; Uridine Diphosphate Glucose

2008
Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor.
    Biochemical pharmacology, 2008, Nov-15, Volume: 76, Issue:10

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Amino Acid Motifs; Animals; Binding Sites; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides

2008
RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes.
    Cellular signalling, 2009, Volume: 21, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenoviridae; Apolipoprotein A-I; Cell Line; Cell Membrane; Endocytosis; Hepatocytes; Humans; Lipoproteins, HDL; Proton-Translocating ATPases; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Small Interfering; Signal Transduction

2009
Analysis of platelet alpha2-adrenergic receptor activity in stable coronary artery disease patients on dual antiplatelet therapy.
    Thrombosis and haemostasis, 2008, Volume: 100, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adrenergic alpha-Antagonists; Aged; Aspirin; Blood Platelets; Clopidogrel; Collagen; Coronary Artery Disease; Drug Resistance; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Middle Aged; Norepinephrine; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Ticlopidine; Treatment Failure

2008
Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation.
    Coronary artery disease, 2009, Volume: 20, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Clinical Trials as Topic; Coronary Artery Disease; Crotalid Venoms; Drug Evaluation, Preclinical; Drug Therapy, Combination; Eptifibatide; Fibrinolytic Agents; Flow Cytometry; Heparin; Hirudins; Humans; Lectins, C-Type; P-Selectin; Peptide Fragments; Peptides; Pilot Projects; Platelet Activating Factor; Platelet Activation; Platelet Function Tests; Recombinant Proteins; Research Design; Thrombin

2009
Mechanism of activation and functional role of protein kinase Ceta in human platelets.
    The Journal of biological chemistry, 2009, May-15, Volume: 284, Issue:20

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Enzyme Activation; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Integrin alpha2; Mice; Mice, Knockout; Peptides, Cyclic; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Phosphatase 1; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thromboxanes

2009
The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels.
    The Journal of biological chemistry, 2009, Jun-12, Volume: 284, Issue:24

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Blood Platelets; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Diphosphate; Humans; In Vitro Techniques; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptor, Adenosine A2A; Receptor, PAR-1; Receptors, Epoprostenol; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thionucleotides

2009
Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin.
    Platelets, 2009, Volume: 20, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Aspirin; Cardiovascular Diseases; Case-Control Studies; Clopidogrel; Drug Monitoring; Female; Flow Cytometry; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine; Tissue Fixation

2009
Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system.
    Platelets, 2010, Volume: 21, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Female; Flow Cytometry; Humans; Iloprost; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Epoprostenol; Receptors, Purinergic P2Y12; Ticlopidine; Young Adult

2010
Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors.
    Molecular and cellular neurosciences, 2010, Volume: 43, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Cell Line; Cells, Cultured; Electrophysiology; Humans; Ion Channel Gating; Membrane Potentials; Potassium Channels, Tandem Pore Domain; Receptors, Purinergic P2

2010
Mutational analysis of residues important for ligand interaction with the human P2Y(12) receptor.
    European journal of pharmacology, 2010, Oct-10, Volume: 644, Issue:1-3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; DNA Mutational Analysis; Humans; Ligands; Mutagenesis, Site-Directed; Protein Binding; Receptors, Purinergic P2Y12

2010
Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist.
    Arteriosclerosis, thrombosis, and vascular biology, 2011, Volume: 31, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cell Adhesion Molecules; Erythrocytes; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Receptors, Thrombin; Thiophenes; Ticagrelor

2011
Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade.
    Pain, 2011, Volume: 152, Issue:8

    Topics: Action Potentials; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Animals, Newborn; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Estrenes; Ganglia, Spinal; Ion Channel Gating; Nucleotides; Patch-Clamp Techniques; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Pyrrolidinones; Rats; Receptors, Purinergic P2Y; Sensory Receptor Cells; Signal Transduction; Statistics, Nonparametric; TRPV Cation Channels; Type C Phospholipases

2011
Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells.
    PloS one, 2011, Volume: 6, Issue:10

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Apyrase; Arachidonic Acid; Cell Degranulation; Cell Survival; Drug Synergism; Epithelial-Mesenchymal Transition; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Peptide Fragments; Platelet Adhesiveness; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Receptors, Thrombin; Reproducibility of Results; Signal Transduction

2011
Short-acting P2Y12 blockade to reduce platelet dysfunction and coagulopathy during experimental extracorporeal circulation and hypothermia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Antithrombin III; Blood Coagulation Disorders; Blood Platelets; Cardiopulmonary Bypass; Cytoplasmic Granules; Extracorporeal Circulation; Humans; Hypothermia, Induced; Peptide Hydrolases; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; Swine

2012
The P2Y(12) antagonists, 2MeSAMP and cangrelor, inhibit platelet activation through P2Y(12)/G(i)-dependent mechanism.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Cell Adhesion Molecules; Colforsin; Cyclic AMP; Epoprostenol; Mice; Mice, Knockout; Microfilament Proteins; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y; Signal Transduction; Thionucleosides

2012
Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network.
    Blood, 2013, Mar-07, Volume: 121, Issue:10

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Antigens, CD; Blood Platelets; Fibrin; GTP-Binding Protein alpha Subunit, Gi2; Hemostasis; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Semaphorins; Signal Transduction; Thrombin

2013
Deciphering of ADP-induced, phosphotyrosine-dependent signaling networks in human platelets by Src-homology 2 region (SH2)-profiling.
    Proteomics, 2013, Volume: 13, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Humans; Iloprost; Phosphorylation; Phosphotyrosine; Platelet Activation; Protein Processing, Post-Translational; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; src Homology Domains; Tandem Mass Spectrometry

2013
Can the antiplatelet effects of cangrelor be reliably studied in mice under in vivo and in vitro conditions using flow cytometry?
    Pharmacological reports : PR, 2013, Volume: 65, Issue:4

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Collagen; Female; Flow Cytometry; Mice; Models, Animal; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2Y Receptor Antagonists; Thrombin

2013
P2Y₁ and P2Y₁₂ receptors in hypoxia- and adenosine diphosphate-induced pulmonary vasoconstriction in vivo in the pig.
    European journal of applied physiology, 2014, Volume: 114, Issue:9

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Pressure; Deoxyadenine Nucleotides; Hypertension, Pulmonary; Hypoxia; Pulmonary Artery; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Swine; Vasoconstriction

2014
Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances.
    Platelets, 2016, Volume: 27, Issue:1

    Topics: Acetylglucosaminidase; Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Epoprostenol; Exocytosis; Humans; Lysosomal Membrane Proteins; Lysosomes; Purinergic P2Y Receptor Antagonists; Receptor, PAR-1; Thrombin

2016
Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
    Arteriosclerosis, thrombosis, and vascular biology, 2016, Volume: 36, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Animals; Aspirin; Blood Coagulation; Blood Platelets; Coronary Thrombosis; Dinucleoside Phosphates; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Fibrinolytic Agents; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Time Factors; Young Adult

2016
Quantification of the Blood Platelet Reactivity in the ADP-Induced Model of Non-Lethal Pulmonary Thromboembolism in Mice with the Use of Laser Doppler Flowmetry.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Area Under Curve; Blood Platelets; Eptifibatide; Intravital Microscopy; Laser-Doppler Flowmetry; Lung; Male; Mesentery; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Pulmonary Embolism; Thrombocytopenia

2016
P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction.
    Neuroscience, 2016, 06-21, Volume: 326

    Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Female; Male; Mice; Miniature Postsynaptic Potentials; Neuromuscular Junction; Purinergic P2 Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides

2016
Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17).
    Medical science monitor : international medical journal of experimental and clinical research, 2017, Feb-22, Volume: 23

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Binding Sites; Chromatography, Affinity; Humans; Immobilized Proteins; Ligands; Models, Molecular; Protein Binding; Receptors, G-Protein-Coupled

2017
Evaluation of the Newly Developed Adenosine Diphosphate-Induced Platelet Aggregation Level System in Aggregometer on Automated Coagulation Analyzer.
    Clinical laboratory, 2019, Dec-01, Volume: 65, Issue:12

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Coagulation Tests; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet-Rich Plasma; Reproducibility of Results

2019
Hypoxia Modulates Platelet Purinergic Signalling Pathways.
    Thrombosis and haemostasis, 2020, Volume: 120, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adolescent; Adult; Altitude; Blood Platelets; Cell Adhesion Molecules; Cohort Studies; Female; Humans; Hypoxia; Male; Microfilament Proteins; Oxygen; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet-Rich Plasma; Receptors, Purinergic; Receptors, Thrombin; Signal Transduction; Young Adult

2020
Inhibitory Effects of P2Y12 Receptor Antagonist on PAR1- and PAR4-AP-Induced Platelet Aggregation in Patients with Stroke or TIA.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2021, Volume: 30, Issue:3

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adult; Aged; Aged, 80 and over; Blood Platelets; Case-Control Studies; Clopidogrel; Female; Humans; Ischemic Attack, Transient; Ischemic Stroke; Male; Middle Aged; Oligopeptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Prospective Studies; Purinergic P2Y Receptor Antagonists; Treatment Outcome

2021
Ginsenosides Rb2 and Rd2 isolated from
    Food & function, 2021, Jul-05, Volume: 12, Issue:13

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Animals; Blood Platelets; Flowers; Ginsenosides; Humans; Mice; Mice, Inbred C57BL; Panax notoginseng; Phosphatidylinositol 3-Kinases; Plants, Medicinal; Platelet Aggregation; Platelet Aggregation Inhibitors; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; Thrombosis

2021
Curcumin by activation of adenosine A
    Biochemical and biophysical research communications, 2022, 01-01, Volume: 586

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Blood Platelets; Cell Adhesion Molecules; Curcuma; Curcumin; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Gene Expression Regulation; Humans; Microfilament Proteins; Phosphoproteins; Phosphorylation; Plant Extracts; Platelet Activation; Platelet Aggregation Inhibitors; Primary Cell Culture; Purinergic P2Y Receptor Antagonists; Receptor, Adenosine A2A; Receptors, Purinergic P2Y12; Signal Transduction

2022