adenosine diphosphate has been researched along with alprostadil in 143 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (45.45) | 18.7374 |
| 1990's | 44 (30.77) | 18.2507 |
| 2000's | 23 (16.08) | 29.6817 |
| 2010's | 9 (6.29) | 24.3611 |
| 2020's | 2 (1.40) | 2.80 |
| Authors | Studies |
|---|---|
| Butt, E; Geiger, J; Nolte, C; Sage, SO; Walter, U | 1 |
| Heemskerk, JW; Sage, SO | 1 |
| Bochkov, VN; Fuki, IV; Lyakishev, AA; Matchin, YG; Tkachuk, VA | 1 |
| Chevillard, C; Launay, JM; Mathieu, MN; Vittet, D | 1 |
| Druker, BJ; Oda, A; Salzman, EW; Smith, M | 1 |
| Peerschke, EI | 2 |
| Donato, R; Rambotti, MG; Spreca, A | 1 |
| Andrieux, A; Gulino, D; Marguerie, G; Rabiet, MJ; Ryckewaert, JJ | 1 |
| Bielawiec, M; Bodzenta-Lukaszyk, A; Giedrojć, J | 1 |
| Beer, JH; Coller, BS; Springer, KT | 1 |
| Dieter, JP; Feinberg, H; Lam, SC; Le Breton, GC; Muscolino, G; Strebel, LC; Taylor, TM | 1 |
| Alvarez, R; Artis, DR; Bruno, JJ; Chang, LF; Eglen, RM; Kluge, AF; Whiting, RL | 1 |
| Daley, JF; Kang, J; Oda, A; Salzman, EW; Smith, M; Ware, JA | 1 |
| Chung-A-On, KO; Davies, JI; Gliddon, AE; Griffiths, KD; Payne, JW | 1 |
| Cazenave, JP; Defreyn, G; Driot, F; Gachet, C; Maffrand, JP; Savi, P | 1 |
| Canciani, MT; Cattaneo, M; Kinlough-Rathbone, RL; Lecchi, A; Mannucci, PM; Mustard, JF; Packham, MA | 1 |
| Chijiwa, T; Igawa, T; Kato, S; Kawamura, K; Kimura, Y; Shimidzu, S; Shiragiku, T; Tani, T; Unemi, F | 1 |
| Bouloux, C; Cazenave, JP; Defreyn, G; Driot, F; Gachet, C; Maffrand, JP; Ohlmann, P | 1 |
| Ahn, CH; Feller, DR; Miller, DD; Schotzinger, RL; Shams, G | 1 |
| Addonizio, VP; Cottrell, ED; Fisher, CA; Kappa, JR; Reiser, HJ; Sinha, AK | 1 |
| Addonizio, VP; Fisher, CA; Kappa, JR; Musial, J | 1 |
| Haslam, RJ; Murphy, W; Williams, KA | 1 |
| Ershov, DE; Fedorov, NA; Tatarintsev, AV; Varfolomeev, SD; Vrzheshch, PV; Zaĭtsev, SV | 1 |
| Clark, RB; Friedman, J; Kunkel, MW; Shenolikar, S | 1 |
| Bushfield, M; Gibson, IF; Hopple, SL; MacIntyre, DE; Murdoch, FA | 1 |
| Kangasaho, M | 1 |
| Bleifeld, W; Hamm, CW; Kupper, W; Terres, W | 1 |
| Fukatsu, Y; Hirano, T; Kameoka, K; Kanai, N; Matsuura, H; Nishikawa, N; Nishio, S; Umetsu, T | 1 |
| Bühler, FR; Dimitrov, D; Resink, TJ; Stucki, S | 1 |
| Coller, BS | 1 |
| Bromberg, ME; Daniel, JL; Salganicoff, L; Sevy, RW | 1 |
| Kariya, T; Morito, F; Sakai, T; Takahata, K; Yamanaka, M | 1 |
| Ehrlich, YH; Hardwick, DH; Kornecki, E; Lenox, RH | 1 |
| Hollister, AS; Lonce, S; Nadeau, JH; Onrot, J; Robertson, D | 1 |
| Cusack, NJ; Hourani, SM; Welford, LA | 1 |
| Holmsen, H; Ovstedal, T; Thorsen, T; Vereide, A | 1 |
| Hakvaag, L; Lyberg, T; Nakstad, B; Stormorken, H | 1 |
| Bellucci, S; Bryckaert, MC; Calvo, F; Camez, A; Dupuy, E; Tobelem, G | 1 |
| Hu, SJ; Jen, CJ | 1 |
| Nachmias, VT; Yoshida, K | 1 |
| Greenberg, JP; Guccione, MA; Harfenist, EJ; Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Perry, DW; Rand, ML | 1 |
| Ershov, DE; Nagaev, IIu; Shevchenko, VP; Vrzheshch, PV; Zaĭtsev, SV | 1 |
| Fasol, R; Fischlein, T; Groscurth, P; Varga, G; Zilla, P | 1 |
| Botting, JH; Oyekan, AO | 1 |
| Boden, G; Capitanio, AM; Hershock, D; Kornecki, E; Lukasiewicz, H; Niewiarowski, S; Rawala, R | 1 |
| Solen, KA; White, JV | 1 |
| Lapetina, EG; Siess, W | 1 |
| Aihara, H; Cleland, ME; Hosoda, K; McCraw, AP; Otomo, S; Sim, AK | 1 |
| Fitscha, P; Kaliman, J; Sinzinger, H | 1 |
| Hantgan, RR; Lewis, JC; Taylor, RG | 1 |
| Koshida, H; Miyamori, I; Morise, T; Takeda, R; Takeda, Y; Yasuhara, S | 1 |
| Cleland, ME; McCraw, AP; Nishio, S; Sim, AK; Umetsu, T | 1 |
| Ma, YH; Ouyang, CH; Teng, CM | 1 |
| Harfenist, EJ; Mustard, JF; Packham, MA | 1 |
| Andries, R; Bourgain, RH; Braquet, M; Braquet, P; Maes, L; Touqui, L | 1 |
| Feinberg, H; Wencel-Drake, JD | 1 |
| Holmsen, H; Steen, VM | 1 |
| Adachi, S; Fujimura, H; Imai, H; Kaiya, H; Muramatsu, Y; Namba, M; Nozaki, M | 1 |
| Clare, KA; Scrutton, MC; Thompson, NT | 1 |
| Kerry, R; Scrutton, MC; Wallis, RB | 1 |
| Haslam, RJ; Vanderwel, M | 1 |
| Gardner, JD; Jackson, MJ; Korman, LY; Lemp, GF | 1 |
| Masiello, NC; Zucker, MB | 1 |
| Aiken, JW; Gorman, RR; Miller, OV; Shebuski, RJ | 1 |
| Kadowitz, PJ; Lippton, HL; Myers, CB; Pontecorvo, EG | 1 |
| Macfarlane, DE; Mills, DC; Srivastava, PC | 1 |
| Cusack, NJ; Hourani, SM | 2 |
| Guccione, MA; Lam, SC; Mustard, JF; Packham, MA | 1 |
| Kinlough-Rathbone, RL; Mustard, JF; Vickers, JD | 1 |
| Cazenave, JP; Dejana, E; Harfenist, EJ; Kinlough-Rathbone, RL; Mustard, JF; Packham, MA; Perry, DW | 1 |
| Inada, Y; Nishikawa, K; Nomura, H; Terashita, Z; Tsushima, S; Yoshioka, Y | 1 |
| Duchastel, A; Frojmovic, MM; Milton, JG | 1 |
| Hatmi, M; Touqui, L; Vargaftig, BB | 1 |
| Colman, RW; Sinha, AK | 1 |
| Azuma, H; Hidaka, H; Nishikawa, M; Yamakado, T | 1 |
| Geling, NG; Kudriashov, SA; Mel'nikova, VI; Pivnitskiĭ, KK | 1 |
| Booth, DG; Fitzpatrick, FA; Honohan, T; McGrath, JP; Morton, DR; Nishizawa, E | 1 |
| Alekseev, OV; Antonikov, IM; Chernukh, AM | 1 |
| Haslam, RJ; McClenaghan, MD | 1 |
| Matsubara, I | 1 |
| Aubert, D; Ferrand, C; Loubrie, JC; Tuong, A; Tuong, CC | 1 |
| Fujitani, B; Hatano, N; Kawasaki, A; Nakatsuji, K; Sakata, M; Shimizu, M; Tsuboi, T; Tsuboshima, M; Yoshida, K | 1 |
| Chirkov, YY; Chirkova, LP; Horowitz, JD; Sage, RE | 1 |
| Dillingham, EO; Gollamudi, R; Handa, RK | 1 |
| Bihour, C; Heilmann, E; Herbert, JM; Maffrand, JP; Nurden, A; Nurden, P; Savi, P | 1 |
| Amrani, DL; Derrick, JM; Gartner, TK | 1 |
| Chao, SH; Huang, TF; Sheu, JR; Yen, MH | 1 |
| Hönig-Liedl, P; Horstrup, K; Jablonka, B; Just, M; Kochsiek, K; Walter, U | 1 |
| Frost, V; Hall, DA; Hourani, SM | 1 |
| Feffer, SE; Fox, R; Jonas, EA; Kosacolsky-Singer, C; Nethala, V; Saladino, CF | 1 |
| Hall, DA; Hourani, SM | 1 |
| Akkawat, B; Cattaneo, M; Cimminiello, C; Kinlough-Rathbone, RL; Mannucci, PM; Packham, MA | 1 |
| Jørgensen, L; Kinlough-Rathbone, RL; Mustard, JF; Nilsen, GJ; Perry, DW | 1 |
| Bechstein, WO; Himmelreich, G; Hundt, K; Neuhaus, P; Riess, H; Roissant, R | 1 |
| Alemany, M; Concord, E; Garin, J; Giles, A; Gulino, D; Marguerie, G; Vinçon, M | 1 |
| Handa, M; Ikeda, Y; Murata, M; Nakamura, K; Oda, A; Tokuhira, M; Watanabe, K; Yokoyama, K | 1 |
| Agrafojo, J; Fullerton, DA; McIntyre, RC | 1 |
| Frölich, JC; Tsikas, D; Viigimaa, M | 1 |
| Fratantoni, JC; Mondoro, TH; Shafer, B; Vostal, JG | 1 |
| Bruckdorfer, KR; Calzada, C; Rice-Evans, CA | 1 |
| Breittmayer, JP; Frelin, C; Gachet, C; Hechler, B; Vigne, P | 1 |
| Reimann, S; Schrör, K; Weber, AA | 1 |
| Heleniak, E; O'Desky, I | 1 |
| Brich, J; Eigenthaler, M; Geiger, J; Herbert, JM; Hönig-Liedl, P; Schanzenbächer, P; Walter, U | 1 |
| Graves, LM; Qu, W; Thurman, RG | 1 |
| Acharya, K; Bhattacharya, S; Mazumder, S; Sinha, AK | 1 |
| Belisario, MA; Della Morte, R; Di Domenico, C; Lucisano, A; Squillacioti, C; Staiano, N; Tafuri, S | 1 |
| Afanasjeva, G; Avdonin, P; Baskova, I; Berezhnoy, S; Gabbasov, Z; Popov, E; Zavalova, L | 1 |
| Cranmer, SL; Dopheide, SM; Dunstan, DE; Giuliano, S; Harper, I; Jackson, SP; Lanza, F; Mangin, P; Mistry, N; Salem, HH; Yuan, Y | 1 |
| Baurand, A; Bourguignon, JJ; Cazenave, JP; Freund, M; Gachet, C; Léon, C; Raboisson, P | 1 |
| Ikeda, T; Kazama, T; Kikura, M; Sato, S | 1 |
| Conde, M; Porras, T; Rosado, JA; Sage, SO | 1 |
| Bayly, WM; Kingston, JK; Meyers, KM; Sellon, DC; Wardrop, KJ | 1 |
| Ervin, AL; Peerschke, EI | 1 |
| Hatae, N; Ichikawa, A; Negishi, M; Sugimoto, Y; Yamaoka, K | 1 |
| Kleinrok, Z; Rajtar, G; Zółkowska, D | 1 |
| Ghebrehiwet, B; Murphy, TK; Peerschke, EI | 1 |
| Budinsky, A; Efthimiou, Y; Oguogho, A; Sinzinger, H; Stomatopoulos, J; Wolfram, R | 1 |
| Bennett, JS; Litvinov, RI; Shuman, H; Vilaire, G; Weisel, JW | 1 |
| Behan, MW; Fox, SC; Heptinstall, S | 1 |
| Kobzar, G; Mardla, V; Samel, N | 1 |
| Frattali, V; Quesada, M; Robertson, R | 1 |
| Clerman, A; Doré, S; Echeverria, V | 1 |
| Chandy, S; Chirkov, YY; Holmes, AS; Horowitz, JD; Kanna, R; Mishra, K | 1 |
| Atar, D; Defranco, A; Mahmud, E; Malinin, A; Pokov, A; Schwartz, D; Schwartz, K; Serebruany, V; Spergling, M | 1 |
| Asai, F; Hagihara, K; Hashimoto, M; Jakubowski, JA; Kurihara, A; Niitsu, Y; Ogawa, T; Sugidachi, A | 1 |
| Diodati, JG; Lordkipanidzé, M; Nguyen, TA; Pharand, C; Schampaert, E | 1 |
| Price, MJ; Teirstein, PS | 1 |
| Einav, Y; Salomon, O; Savion, N; Shenkman, B; Varon, D | 1 |
| Gouya, G; Jilma, B; Siller-Matula, JM; Wolzt, M | 1 |
| Broos, K; Deckmyn, H; Fontayne, A; Nurden, AT; Ruan, C; Salles, I; Szántó, T; Vanhoorelbeke, K | 1 |
| Assinger, A; Schmid, W; Volf, I | 1 |
| Desta, Z; Flockhart, DA; Jin, Y; Kovacs, R; Kreutz, RP; Kreutz, Y; Miao, J; Nystrom, P | 1 |
| Bauersachs, J; Flierl, U; Fraccarollo, D; Lausenmeyer, E; Massberg, S; Rosenstock, T; Schäfer, A; Schulz, C | 1 |
| Bagoly, Z; Csiba, L; Kappelmayer, J; Magyar, T; Muszbek, L; Pongrácz, E; Sarkady, F | 1 |
| Dhillon, K; Dovlatova, N; Fox, SC; Glenn, JR; Heptinstall, S; White, AE | 1 |
| Curzen, N; Englyst, N; Hobson, A; Khanna, V; Mikael, R; Sambu, N | 1 |
| Galuszka, J; Hlusi, A; Hutyra, M; Indrak, K; Indrakova, J; Krcova, V; Slavik, L; Ulehlova, J | 1 |
| Armstrong, PC; Curzen, N; Khanna, V; Warner, TD | 1 |
| Begonja, AJ; Bohdan, N; Caparrós-Pérez, E; Ferrer-Marín, F; Llanos, MDC; Mota-Pérez, N; Palma-Barqueros, V; Rivera, J; Sola-Visner, M; Teruel-Montoya, R; Torregrosa, JM; Vicente, V | 1 |
| Bokemeyer, C; Fiehler, J; Frölich, AM; Haddad, M; Holst, B; Holstein, K; Janjetovic, S; Langer, F; Renné, T; Rolling, CC; Rolling, T; Tomada, J; Voigtländer, M | 1 |
2 review(s) available for adenosine diphosphate and alprostadil
| Article | Year |
|---|---|
Characterisation of ADP receptors.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Alprostadil; Binding, Competitive; Blood Platelets; Chemical Phenomena; Chemistry; Cyclic AMP; Humans; Platelet Aggregation; Receptors, Cell Surface; Receptors, Purinergic; Structure-Activity Relationship | 1985 |
Histamine and prostaglandins in schizophrenia: revisited.
Topics: Adenosine Diphosphate; Alprostadil; Cyclic AMP; Dopamine; Histamine; Humans; Interleukins; Models, Biological; Phospholipases A; Prostaglandins; Schizophrenia | 1999 |
7 trial(s) available for adenosine diphosphate and alprostadil
| Article | Year |
|---|---|
Single-blind study of epoprostenol and 6-keto-prostaglandin E1 in man: effects of platelet aggregation and plasma renin.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Pressure; Epoprostenol; Heart Rate; Humans; Male; Platelet Aggregation; Renin | 1985 |
Evidence that intraoperative prostaglandin E1 infusion reduces impaired platelet aggregation after reperfusion in orthotopic liver transplantation.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Collagen; Female; Humans; Infusions, Intravenous; Intraoperative Period; Liver Transplantation; Male; Middle Aged; Platelet Aggregation; Prospective Studies; Reperfusion; Ristocetin | 1993 |
The influence of antioxidant nutrients on platelet function in healthy volunteers.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Alprostadil; Antioxidants; Arachidonic Acid; Ascorbic Acid; beta Carotene; beta-Thromboglobulin; Blood Platelets; Collagen; Double-Blind Method; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Vitamin E | 1997 |
Daily prickly pear consumption improves platelet function.
Topics: Adenosine Diphosphate; Adult; Alprostadil; beta-Thromboglobulin; Blood Platelets; Cholesterol, LDL; Collagen; Diet; Endothelial Cells; Epoprostenol; Female; Humans; Hyperlipoproteinemia Type II; Male; Medicine, Traditional; Opuntia; Plants, Medicinal; Platelet Adhesiveness; Platelet Aggregation; Platelet Count; Platelet Factor 4; Thromboxane B2 | 2003 |
Monitoring platelet inhibition after clopidogrel with the VerifyNow-P2Y12(R) rapid analyzer: the VERIfy Thrombosis risk ASsessment (VERITAS) study.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Stents; Thrombosis; Ticlopidine | 2007 |
Assessment of VerifyNow P2Y12 assay accuracy in evaluating clopidogrel-induced platelet inhibition.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Clopidogrel; Double-Blind Method; Female; Humans; Male; Peptide Fragments; Platelet Aggregation; Platelet Aggregation Inhibitors; Point-of-Care Systems; Prospective Studies; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sample Size; Ticlopidine | 2008 |
Cross validation of the Multiple Electrode Aggregometry. A prospective trial in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Aspirin; Clopidogrel; Electrodes; Female; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Ticlopidine; Time Factors; Young Adult | 2009 |
134 other study(ies) available for adenosine diphosphate and alprostadil
| Article | Year |
|---|---|
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Cell Compartmentation; Cyclic GMP; Cytoplasm; Humans; In Vitro Techniques; Ion Channel Gating; Kinetics; Molsidomine; Nitroprusside; Phosphoproteins; Protein Kinases; Receptors, Cell Surface; Thrombin; Vasodilator Agents | 1992 |
Thromboxane receptor stimulation inhibits adenylate cyclase and reduces cyclic AMP-mediated inhibition of ADP-evoked responses in fura-2-loaded human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Alprostadil; Calcium; Colforsin; Cyclic AMP; Fura-2; Humans; Manganese; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1992 |
Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins.
Topics: Adenosine Diphosphate; Adolescent; Adult; Alprostadil; Blood Platelets; Calcium; Child; Cytoplasm; Epinephrine; Female; Homozygote; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Platelet Activating Factor; Receptors, Cell Surface; Receptors, Lipoprotein | 1992 |
Platelet receptor expression on three human megakaryoblast-like cell lines.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Cells, Cultured; Cyclic AMP; Endothelins; Epinephrine; Hematopoietic Stem Cells; Humans; Megakaryocytes; Receptors, Cell Surface; Signal Transduction; Thrombin | 1992 |
Inhibition by sodium nitroprusside or PGE1 of tyrosine phosphorylation induced in platelets by thrombin or ADP.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Blotting, Western; Cyclic GMP; Cytosol; Electrophoresis, Polyacrylamide Gel; Humans; In Vitro Techniques; Kinetics; Nitroprusside; Phosphoproteins; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Thrombin; Tyrosine | 1992 |
Recognition of platelet-associated fibrinogen by polyclonal antibodies: correlation with platelet aggregation.
Topics: Adenosine Diphosphate; Alprostadil; Antibodies; Blood Platelets; Calcimycin; Chymotrypsin; Cytochalasin D; Fibrinogen; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Kinetics; Platelet Aggregation; Platelet Membrane Glycoproteins; Thrombin | 1992 |
Particulate guanylate cyclase and adenylate cyclase activities after activation with various agents in rabbit platelets. An ultracytochemical study.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Animals; Atrial Natriuretic Factor; Blood Platelets; Cell Membrane; Enzyme Activation; Guanylate Cyclase; Histocytochemistry; Insulin; Microscopy, Electron; Platelet Activation; Rabbits; Thrombin | 1991 |
Identification of a monoclonal antibody against platelet GPIIb that interacts with a calcium-binding site and induces aggregation.
Topics: Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Antibodies, Monoclonal; Antibody Specificity; Binding Sites; Blood Platelets; Calcium; Epitopes; Fibrinogen; Immunoglobulin Fab Fragments; Immunoglobulin G; Molecular Sequence Data; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Fibronectin; Receptors, Immunologic; Receptors, Vitronectin; Serotonin | 1990 |
Investigation of prostaglandins in the culture supernatant of mononuclear cells and its influence on platelet aggregation.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Cells, Cultured; Culture Media; Dinoprost; Endotoxins; Escherichia coli; Humans; In Vitro Techniques; Lipopolysaccharides; Lymphocytes; Monocytes; Phytohemagglutinins; Platelet Aggregation; Prostaglandins; Reference Values | 1990 |
Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor.
Topics: Acrylic Resins; Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Blood Platelets; Humans; Integrins; Microspheres; Molecular Sequence Data; Oligopeptides; Platelet Membrane Glycoproteins; Serotonin | 1992 |
Rapid dissociation of platelet-rich fibrin clots in vitro by a combination of plasminogen activators and antiplatelet agents.
Topics: Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Blood Coagulation; Blood Platelets; Fibrin; Fibrinolysis; Humans; Indomethacin; Kinetics; Molecular Sequence Data; Plasminogen Activators; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Streptokinase; Thrombin; Tissue Plasminogen Activator | 1991 |
Stimulation of prostaglandin D2 receptors on human platelets by analogs of prostacyclin.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Blood Platelets; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Epoprostenol; Female; Humans; Hydantoins; Molecular Conformation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Stereoisomerism | 1991 |
Quasi-simultaneous measurement of ionized calcium and alpha-granule release in individual platelets.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Calcium Channels; Cytoplasmic Granules; Cytosol; Egtazic Acid; Fluorescent Dyes; Humans; In Vitro Techniques; Kinetics; Spectrometry, Fluorescence; Thrombin; Time Factors | 1991 |
Observations on platelet prostaglandin metabolism in schizophrenia: the response to ADP.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Diphosphate; Alprostadil; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Reference Values; Schizophrenia | 1991 |
Ticlopidine and clopidogrel (SR 25990C) selectively neutralize ADP inhibition of PGE1-activated platelet adenylate cyclase in rats and rabbits.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Clopidogrel; Enzyme Activation; Female; In Vitro Techniques; Platelet Aggregation Inhibitors; Rabbits; Rats; Rats, Inbred Strains; Stereoisomerism; Ticlopidine | 1991 |
Released adenosine diphosphate stabilizes thrombin-induced human platelet aggregates.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alprostadil; beta-Thromboglobulin; Chymotrypsin; Cytoplasmic Granules; Epinephrine; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Factor 4; Serotonin; Thrombin | 1990 |
Potentiation of anti-platelet aggregating activity of cilostazol with vascular endothelial cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Alprostadil; Azoles; Cells, Cultured; Cilostazol; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Nephelometry and Turbidimetry; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetrazoles; Thromboxane B2 | 1990 |
The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Bleeding Time; Blood Platelets; Calcium; Cyclic AMP; Cytoplasm; Enzyme Activation; Epinephrine; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine | 1990 |
Stereostructure activity relationships of catecholamines on human platelet function.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Catecholamines; Clonidine; Deoxyepinephrine; Dopamine; Epinephrine; Humans; Isomerism; Isoproterenol; Nordefrin; Norepinephrine; Phentolamine; Platelet Aggregation; Platelet Aggregation Inhibitors; Structure-Activity Relationship | 1990 |
Comparison of equimolar concentrations of iloprost, prostacyclin, and prostaglandin E1 on human platelet function.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Coronary Circulation; Cyclic AMP; Epinephrine; Epoprostenol; Humans; Iloprost; In Vitro Techniques; Platelet Aggregation; Rats; Thrombin | 1987 |
Quantitation of platelet preservation with prostanoids during simulated bypass.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Blood Specimen Collection; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Epinephrine; Epoprostenol; Extracorporeal Circulation; Humans; Iloprost; Platelet Count; Prostaglandins | 1987 |
Effects of activation of protein kinase C on the agonist-induced stimulation and inhibition of cyclic AMP formation in intact human platelets.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Alprostadil; Blood Platelets; Colforsin; Cyclic AMP; Diglycerides; Enzyme Activation; Epinephrine; Humans; Prostaglandin D2; Prostaglandins D; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
[Kinetics of the cellular response: the phenomenon of supercooperativity in platelet aggregation].
Topics: Adenosine Diphosphate; Alprostadil; Arachidonic Acid; Arachidonic Acids; Epinephrine; Humans; In Vitro Techniques; Indomethacin; Kinetics; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 1989 |
Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Cell Line; Cell Membrane; Cell-Free System; Colforsin; Enzyme Activation; Epinephrine; In Vitro Techniques; Lymphoma; Protein Kinases; Receptors, Adrenergic, beta; Tumor Cells, Cultured | 1989 |
Effects of protein kinase C activation on human platelet cyclic AMP metabolism.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Blood Platelets; Cyclic AMP; Enzyme Activation; Epinephrine; Humans; In Vitro Techniques; Prostaglandin D2; Prostaglandins D; Protein Kinase C; Tetradecanoylphorbol Acetate | 1987 |
Effects of lidocaine, codeine and vadocaine hydrochloride on platelet aggregation in human platelet-rich plasma.
Topics: Adenosine Diphosphate; Alprostadil; Antitussive Agents; Bucladesine; Codeine; Female; Humans; In Vitro Techniques; Lidocaine; Male; Piperidines; Platelet Aggregation; Thromboxane B2 | 1988 |
[Thrombocyte function in unstable angina pectoris].
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Angina Pectoris; Angina, Unstable; Blood Platelets; Collagen; Coronary Disease; Cyclic AMP; Humans; Infant; Platelet Aggregation; Prospective Studies | 1988 |
The in vitro and ex vivo antiplatelet effect of TRK-100, a stable prostacyclin analog, in several species.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Cats; Cyclic AMP; Dogs; Epoprostenol; Guinea Pigs; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Species Specificity | 1988 |
The influence of activating hormones on human platelet membrane Ca2+-ATPase activity.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcimycin; Calcium-Transporting ATPases; Cell Membrane; Colforsin; Ethers; Humans; Ionomycin; Kinetics; Platelet Activating Factor; Tetradecanoylphorbol Acetate; Thrombin; Vasopressins | 1986 |
A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.
Topics: Adenosine Diphosphate; Alprostadil; Antibodies, Monoclonal; Antibody Specificity; Apyrase; Blood Platelets; Calcimycin; Dibucaine; Epinephrine; Glycoproteins; Humans; Kinetics; Macromolecular Substances; Membrane Proteins; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins E; Protein Conformation; Receptors, Cell Surface; Thrombin | 1985 |
Role of myosin phosphorylation in contractility of a platelet aggregate.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Cyclic AMP; Egtazic Acid; Epoprostenol; Humans; In Vitro Techniques; Kinetics; Myosins; Phosphorylation; Platelet Aggregation; Potassium; Prostaglandins E; Stress, Mechanical | 1985 |
Effect of forskolin on platelet deaggregation and cyclic AMP generation.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Colforsin; Collagen; Cyclic AMP; Drug Synergism; Epoprostenol; Humans; In Vitro Techniques; Phosphorylation; Platelet Aggregation; Proteins | 1985 |
Proteolysis of the platelet surface: dissociation of shape change from aggregation.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Blood Platelets; Cell Membrane; Chymotrypsin; Cyclic AMP; Epinephrine; Humans; Platelet Aggregation | 1986 |
Plasma catecholamine modulation of alpha 2 adrenoreceptor agonist affinity and sensitivity in normotensive and hypertensive human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adult; Alprostadil; Binding, Competitive; Blood Platelets; Catecholamines; Dose-Response Relationship, Drug; Epinephrine; Humans; Hypertension; Platelet Aggregation; Posture; Receptors, Adrenergic, alpha; Sodium; Thermodynamics; Yohimbine | 1986 |
Effects of platelet antagonists on the reduction in platelet density caused by microbubbles in vitro.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Alprostadil; Antimycin A; Blood Platelets; Calcium; Cyclooxygenase Inhibitors; Decompression Sickness; Deoxyglucose; Gases; Humans; Nitrogen; Platelet Aggregation; Receptors, Adrenergic | 1986 |
Dissociation of the aggregating effect and the inhibitory effect upon cyclic adenosine monophosphate accumulation by adrenaline and adenosine diphosphate in human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Alprostadil; Blood Coagulation Disorders; Blood Platelets; Cyclic AMP; Epinephrine; Humans; Platelet Aggregation | 1987 |
Human platelet-tumor cell interactions vary with the tumor cell lines.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Alprostadil; Apyrase; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Breast Neoplasms; Carcinoma; Cell Line; Creatine Kinase; Humans; Neoplasm Metastasis; Platelet Aggregation; Thromboxane B2 | 1986 |
Direct platelet-fibrin interaction that does not require platelet activation.
Topics: Adenosine Diphosphate; Alprostadil; Aspirin; Blood Platelets; Egtazic Acid; Fibrin; HEPES; Humans; Hydrogen-Ion Concentration; Kinetics; Nephelometry and Turbidimetry; Oligopeptides; Platelet Aggregation; Polymers; Serotonin | 1987 |
Phorbol ester stimulates calcium sequestration in saponized human platelets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Diphosphate; Alprostadil; Benzofurans; Biological Transport, Active; Blood Platelets; Calcimycin; Calcium; Calcium Radioisotopes; Chelating Agents; Fura-2; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Thrombin | 1987 |
Effects of plasmin on rabbit platelets.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Fibrinogen; Fibrinolysin; In Vitro Techniques; Platelet Aggregation; Prostaglandins E; Rabbits; Serotonin; Thrombin | 1985 |
[Synthesis of tritium-labelled prostaglandin E1 and its binding to human platelets].
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Chemical Phenomena; Chemistry; Humans; In Vitro Techniques; Isotope Labeling; Kinetics; Ligands; Platelet Aggregation; Radioligand Assay; Tritium | 1988 |
PGI2 and PGE1 induce morphological alterations in human platelets similar to those of the initial phase of activation.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Epoprostenol; Female; Humans; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Platelet Aggregation | 1987 |
Inhibition of adenosine diphosphate-induced intravascular aggregation of rat platelets in vivo by 6-oxo-prostaglandin E1.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Epoprostenol; Kinetics; Platelet Aggregation; Rats; Structure-Activity Relationship | 1987 |
Fibrinogen interaction with platelets of diabetic subjects.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Antibodies, Monoclonal; Binding Sites; Blood Platelets; Chymotrypsin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Fibrinogen; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Membrane Glycoproteins; Reference Values | 1987 |
Correlation between chemical stimulation and filtration flow resistance in human platelet aggregates.
Topics: Adenosine Diphosphate; Alprostadil; Blood Flow Velocity; Blood Platelets; Drug Interactions; Epinephrine; Filtration; Humans; Methods; Platelet Aggregation; Pressure; Stimulation, Chemical; Vascular Resistance | 1987 |
Phorbol esters sensitize platelets to activation by physiological agonists.
Topics: Adenosine Diphosphate; Alprostadil; Collagen; Humans; Kinetics; Phorbol Esters; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Structure-Activity Relationship; Vasopressins | 1987 |
The effect of prostaglandin E1 incorporated in lipid microspheres on thrombus formation and thrombus disaggregation and its potential to target to the site of vascular lesions.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Cricetinae; Fibrinolytic Agents; Male; Mesocricetus; Microspheres; Models, Biological | 1986 |
Platelet sensitivity to antiaggregatory prostaglandins (PGE1,D2,I2) in patients with peripheral vascular disease.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Blood Platelets; Diabetes Mellitus; Epoprostenol; Female; Humans; Hyperlipoproteinemias; Male; Middle Aged; Platelet Aggregation; Prostaglandin D2; Prostaglandins D; Prostaglandins E; Risk; Smoking; Vascular Diseases | 1985 |
Platelets interact with fibrin only after activation.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Batroxobin; Blood Platelets; Epoprostenol; Fibrin; Fibrin Fibrinogen Degradation Products; Humans; Light; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Oligopeptides; Platelet Aggregation; Prostaglandins E; Scattering, Radiation; Thrombin | 1985 |
Effect of a stable prostacyclin analogue on platelet function and experimentally-induced thrombosis in the microcirculation.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Cricetinae; Dogs; Epoprostenol; Fibrinolytic Agents; Guinea Pigs; Humans; In Vitro Techniques; Male; Mesocricetus; Microcirculation; Platelet Aggregation; Rabbits; Rats; Species Specificity; Time Factors | 1985 |
Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Chymotrypsin; Collagen; Fibrinogen; Heparin; Hirudins; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Thrombin; Viper Venoms | 1985 |
Comparison of the interactions of fibrinogen and soluble fibrin with washed rabbit platelets stimulated with ADP.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Apyrase; Blood Platelets; Creatine Kinase; Edetic Acid; Fibrin; Fibrinogen; Oligopeptides; Phosphocreatine; Platelet Aggregation; Prostaglandins E; Rabbits | 1985 |
The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arteries; Diterpenes; Edetic Acid; Epoprostenol; Ginkgolides; Guinea Pigs; In Vitro Techniques; Lactones; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Quinacrine; Thrombosis | 1985 |
ADP induced depolarization of human platelet membrane potential.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Epinephrine; Humans; In Vitro Techniques; Membrane Potentials; Platelet Aggregation; Potassium; Prostaglandins E; Thiocyanates | 1985 |
Inhibition of ADP-induced responses in human platelets by agents elevating the cyclic AMP level: comparison of aggregation and shape change.
Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Blood Platelets; Cyclic AMP; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins E; Receptors, Cell Surface | 1984 |
Platelet aggregation response in schizophrenia and prostaglandin E1.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Antipsychotic Agents; Arachidonic Acids; Collagen; Dopamine; Epinephrine; Female; Humans; Male; Platelet Aggregation; Prostaglandins E; Schizophrenia; Serotonin | 1983 |
Effects of alpha 2-adrenoceptor agonists and of related compounds on aggregation of, and on adenylate cyclase activity in, human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adult; Alprostadil; Blood Platelets; Cyclic AMP; Drug Interactions; Epinephrine; Humans; In Vitro Techniques; Papaverine; Platelet Aggregation; Prostaglandins E | 1984 |
Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility.
Topics: Adenosine Diphosphate; Adrenergic beta-Antagonists; Alprostadil; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Lipids; Platelet Aggregation; Propranolol; Prostaglandins E; Solubility; Tetradecanoylphorbol Acetate; Thromboxane B2 | 1984 |
Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor).
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Creatine Kinase; Cyclic AMP; Indomethacin; Lysophosphatidylcholines; Phosphocreatine; Platelet Activating Factor; Prostaglandins E; Rabbits | 1982 |
Mechanism of action of ATP on intestinal epithelial cells. Cyclic AMP-mediated stimulation of active ion transport.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alprostadil; Animals; Biological Transport, Active; Cyclic AMP; Guanylyl Imidodiphosphate; Guinea Pigs; Intestine, Small; Kinetics; Male; Prostaglandins E; Vasoactive Intestinal Peptide | 1982 |
Platelet aggregation caused by dithiothreitol.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogen; Glycoproteins; Humans; Mercaptoethanol; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins E | 1984 |
6-keto-prostaglandin E1 is not equipotent to prostacyclin (PGI2) as an antiaggregatory agent.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Cyclic AMP; Dose-Response Relationship, Drug; Epoprostenol; Humans; Platelet Aggregation; Prostaglandins E | 1980 |
Inhibition of platelet aggregation by 6-keto-PGE1; lack of an effect on cyclic GMP levels.
Topics: Adenosine Diphosphate; Alprostadil; Arachidonic Acids; Blood Platelets; Collagen; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Platelet Aggregation; Prostaglandins E | 1981 |
Binding of 2-azidoadenosine [beta-32P]diphosphate to the receptor on intact human blood platelets which inhibits adenylate cyclase.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Azides; Binding Sites; Blood Platelets; Cell Membrane; Cyclic AMP; Humans; Kinetics; Phosphorus Radioisotopes; Platelet Aggregation; Prostaglandins E; Spectrophotometry, Ultraviolet | 1982 |
Adenosine 5-diphosphate antagonists and human platelets: no evidence that aggregation and inhibition of stimulated adenylate cyclase are mediated by different receptors.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Blood Platelets; Humans; In Vitro Techniques; Kinetics; Platelet Aggregation; Prostaglandins E; Receptors, Cell Surface; Receptors, Purinergic | 1982 |
Effect of cAMP phosphodiesterase inhibitors on ADP-induced shape change, cAMP and nucleoside diphosphokinase activity of rabbit platelets.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Cyclic AMP; In Vitro Techniques; Nucleoside-Diphosphate Kinase; Phosphotransferases; Prostaglandins E; Rabbits; Theophylline | 1982 |
The effect of prostaglandins E1, I2 and F2 alpha on the shape and phosphatidylinositol-4,5-bisphosphate metabolism of washed rabbit platelets.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Cyclic AMP; Dinoprost; Epoprostenol; Microscopy, Electron; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Prostaglandins; Prostaglandins E; Prostaglandins F; Rabbits | 1982 |
Factors influencing the deaggregation of human and rabbit platelets.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Calcium; Collagen; Edetic Acid; Fibrin; Humans; Macromolecular Substances; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandins E; Rabbits; Receptors, Cell Surface; Thrombin | 1983 |
CV-3988 - a specific antagonist of platelet activating factor (PAF).
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Arachidonic Acids; Blood Pressure; Calcimycin; Collagen; Dose-Response Relationship, Drug; Male; Micelles; Phospholipid Ethers; Platelet Activating Factor; Platelet Aggregation; Prostaglandins E; Rabbits; Rats; Rats, Inbred Strains; Thiazoles | 1983 |
Microscopic measurements of platelet aggregation reveal a low ADP-dependent process distinct from turbidometrically measured aggregation.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Dose-Response Relationship, Drug; Edetic Acid; Female; Fibrinolytic Agents; Humans; Kinetics; Male; Nephelometry and Turbidimetry; Platelet Aggregation; Prostaglandins E; Quinazolines | 1983 |
Interactions between dipyridamole and prostaglandin E1 with ADP-induced aggregation of rat platelet in whole blood.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Dipyridamole; Drug Interactions; Male; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains | 1984 |
Inhibition of ADP-induced platelet aggregation by reduced factor Xa.
Topics: Adenosine Diphosphate; Alprostadil; Chemical Phenomena; Chemistry; Dithiothreitol; Factor X; Factor Xa; Humans; Oxidation-Reduction; Platelet Aggregation; Prostaglandins E; Prostaglandins E, Synthetic; Sepharose; Solubility; Thromboxane A2 | 1983 |
Pharmacological properties of platelet strips.
Topics: Adenosine Diphosphate; Alprostadil; Angiotensin II; Aorta; Blood Platelets; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Papaverine; Platelet Aggregation; Prostaglandins E; Serotonin; Sulfonamides; Time Factors | 1983 |
[Antiaggregation activity of various synthetic prostaglandins].
Topics: Adenosine Diphosphate; Alprostadil; Animals; Depression, Chemical; Dinoprostone; Dose-Response Relationship, Drug; Epoprostenol; In Vitro Techniques; Isomerism; Male; Platelet Aggregation; Prostaglandins E; Prostaglandins, Synthetic; Rabbits; Structure-Activity Relationship | 1982 |
Hydrolysis of an orally active platelet inhibitory prostanoid amide in the plasma of several species.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Dogs; Female; Guinea Pigs; Haplorhini; Humans; Hydrolysis; Macaca fascicularis; Macaca mulatta; Male; Platelet Aggregation; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Species Specificity | 1980 |
Differential inhibition by adenosine or by prostaglandin E1 of human platelet aggregation induced by adenosine 5'-O-(1-thiodiphosphate) and adenosine 5'-O-(2-thiodiphosphate).
Topics: Adenosine Diphosphate; Alprostadil; Humans; In Vitro Techniques; Platelet Aggregation; Prostaglandins E; Thionucleotides | 1982 |
[Effect of prostaglandins E1 and E2 on thrombocyte form and aggregation].
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Chlortetracycline; Dinoprostone; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Platelet Aggregation; Prostaglandins E; Rats | 1982 |
Measurement of circulating prostacyclin.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Epoprostenol; Kinetics; Platelet Aggregation; Prostaglandins; Prostaglandins E; Rabbits | 1981 |
[Study of platelet aggregation by the filtration pressure method (author's transl)].
Topics: Adenosine Diphosphate; Alprostadil; Animals; Bradykinin; Dogs; Epoprostenol; Female; Filtration; Indomethacin; Male; Platelet Aggregation; Platelet Count; Pressure; Prostaglandins E; Sulfinpyrazone; Vasodilator Agents | 1981 |
Modulation of the inhibitory action of prostaglandin E1 on platelet aggregation in rats: a study with ticlopidine, aspirin, dipyridamole and sulfinpyrazone.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Aspirin; Dipyridamole; Male; Phosphorylation; Platelet Aggregation; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfinpyrazone; Thiophenes; Ticlopidine | 1982 |
Pharmacological evaluation of ONO 1206, a prostaglandin E1 derivative, as antianginal agent.
Topics: Adenosine Diphosphate; Administration, Oral; Alprostadil; Angina Pectoris; Animals; Collagen; Drug Evaluation, Preclinical; Guinea Pigs; Heart; Humans; Platelet Aggregation; Prostaglandins E; Prostaglandins E, Synthetic; Rats; Structure-Activity Relationship; Vasodilation; Vasopressins | 1980 |
Impaired responsiveness of platelets from patients with stable angina pectoris to antiaggregating and cyclicAMP-elevating effects of prostaglandin E1.
Topics: Adenosine Diphosphate; Adult; Age Factors; Aged; Alprostadil; Angina Pectoris; Blood Platelets; Cohort Studies; Cyclic AMP; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors | 1995 |
Antithrombotic nipecotamide increases cyclic AMP levels and inhibits protein phosphorylation in human platelets.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Blood Proteins; Collagen; Cyclic AMP; Female; Humans; Male; Nipecotic Acids; Phosphorylation; Platelet Aggregation Inhibitors | 1995 |
An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.
Topics: Adenosine Diphosphate; Alprostadil; Blood Coagulation Disorders; Blood Platelets; Cyclic AMP; Cytoplasmic Granules; Epinephrine; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Purinergic P2; Thionucleotides; White People | 1995 |
Characterization of adhesion of non-exogenously stimulated and resting platelets in normal plasma to fibrinogen and its fragments.
Topics: Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Binding Sites; Blood; Blood Platelets; Calcium; Citrates; Citric Acid; Fibrinogen; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Molecular Sequence Data; Peptide Fragments; Platelet Activation; Platelet Adhesiveness | 1994 |
In vivo antithrombotic effect of triflavin, an Arg-Gly-Asp containing peptide on platelet plug formation in mesenteric microvessels of mice.
Topics: Acute Disease; Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Animals; Blood Pressure; Endothelium, Vascular; Fluorescein; Fluoresceins; Heparin; Indomethacin; Male; Mesentery; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligopeptides; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Pulmonary Embolism; Thrombosis; Venules | 1994 |
Phosphorylation of focal adhesion vasodilator-stimulated phosphoprotein at Ser157 in intact human platelets correlates with fibrinogen receptor inhibition.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Blood Proteins; Cell Adhesion Molecules; Colforsin; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; In Vitro Techniques; Kinetics; Membrane Proteins; Microfilament Proteins; Molsidomine; Nitroprusside; Phosphoproteins; Phosphoserine; Platelet Membrane Glycoproteins; Protein Kinases; Protein-Tyrosine Kinases; Serine; Vasodilator Agents | 1994 |
Effects of extracellular divalent cations on responses of human blood platelets to adenosine 5'-diphosphate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Alprostadil; Blood Platelets; Calcium; Cations, Divalent; Dose-Response Relationship, Drug; Humans; Magnesium; Platelet Aggregation | 1994 |
The effect of parenteral lipid emulsion-induced hyperlipidemia on prostaglandin E1 modulation of platelet function.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Dose-Response Relationship, Drug; Drug Combinations; Emulsions; Fat Emulsions, Intravenous; Glycerol; Humans; Hyperlipidemias; In Vitro Techniques; Infusions, Intravenous; Lecithins; Male; Phospholipids; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Safflower Oil; Soybean Oil | 1993 |
Stabilization of platelet-fibrinogen interactions is an integral property of the glycoprotein IIb-IIIa complex.
Topics: Adenosine Diphosphate; Alprostadil; Antibodies, Monoclonal; Blood Platelets; Chromatography, Affinity; Chromatography, Gel; Drug Interactions; Drug Stability; Edetic Acid; Fibrinogen; Humans; Platelet Membrane Glycoproteins; Time Factors | 1994 |
Effects of suramin on increases in cytosolic calcium and on inhibition of adenylate cyclase induced by adenosine 5'-diphosphate in human platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Blood Platelets; Calcium; Cyclic AMP; Cytosol; Epinephrine; Humans; In Vitro Techniques; Suramin | 1994 |
Ticlopidine facilitates the deaggregation of human platelets aggregated by thrombin.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Chymotrypsin; Female; Fibrinolysin; Hirudins; Humans; Male; Middle Aged; Platelet Aggregation; Thrombin; Ticlopidine | 1994 |
Rabbit lung macrophages stimulate platelets in vitro as observed by density-gradient centrifugation and transmission electron microscopy.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Cell Communication; Cells, Cultured; Centrifugation, Density Gradient; Creatine Kinase; Edetic Acid; Ferric Compounds; Macrophages, Alveolar; Microscopy, Electron; Phosphocreatine; Platelet Activating Factor; Platelet Activation; Rabbits; Thrombin; Triazolam | 1993 |
Sequence 274-368 in the beta 3-subunit of the integrin alpha IIb beta 3 provides a ligand recognition and binding domain for the gamma-chain of fibrinogen that is independent of platelet activation.
Topics: Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Antibodies, Monoclonal; Binding Sites; Egtazic Acid; Fibrinogen; Humans; Ligands; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Recombinant Fusion Proteins; Thrombin | 1996 |
Protein tyrosine phosphorylation in human platelets during shear stress-induced platelet aggregation (SIPA) is regulated by glycoprotein (GP) Ib/IX as well as GP IIb/IIIa and requires intact cytoskeleton and endogenous ADP.
Topics: Adenosine Diphosphate; Alprostadil; Amino Acid Sequence; Blood Platelets; Blood Proteins; Cytoskeleton; Ethanol; Humans; Molecular Sequence Data; Molecular Weight; Oligopeptides; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Processing, Post-Translational; Signal Transduction; Stress, Mechanical | 1995 |
Pulmonary vascular smooth muscle relaxation by cAMP-mediated pathways.
Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Animals; Cyclic AMP; Dimaprit; Dose-Response Relationship, Drug; Isoproterenol; Male; Muscle, Smooth, Vascular; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Vasodilation | 1996 |
Platelet aggregation, sensitivity to prostaglandin E1 and thromboxane A2 release in recombinant hirudin- and heparin-anticoagulated blood.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Female; Gas Chromatography-Mass Spectrometry; Heparin; Hirudins; Humans; Male; Platelet Aggregation; Recombinant Proteins; Thromboxane A2 | 1996 |
Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Calcium; Cell Adhesion Molecules; Cyclic AMP; Cytosol; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Phosphorylation; Platelet Activation; Protein-Tyrosine Kinases; Thrombin; Thromboxane A2; Tyrosine | 1996 |
Benzoyl ATP is an antagonist of rat and human P2Y1 receptors and of platelet aggregation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Brain; Calcium; Cholera Toxin; Cyclic AMP; Endothelium, Vascular; Humans; Inhibitory Concentration 50; Jurkat Cells; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Transfection | 1999 |
Specific inhibition of ADP-induced platelet aggregation by clopidogrel in vitro.
Topics: Adenosine Diphosphate; Alprostadil; Apyrase; Blood Platelets; Clopidogrel; Cyclic AMP; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Serum Albumin; Stereoisomerism; Ticlopidine; Time Factors | 1999 |
Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Calcium; Clopidogrel; Cyclic AMP; Epinephrine; Female; Humans; Male; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Ticlopidine; Vasodilator Agents | 1999 |
PGE(2) stimulates O(2) uptake in hepatic parenchymal cells: involvement of the cAMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine Diphosphate; Alprostadil; Animals; Anti-Ulcer Agents; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dinoprostone; Electron Transport; Female; Liver; Mitochondria; Oxygen; Oxygen Consumption; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin E; Signal Transduction; Succinic Acid | 1999 |
Stimulation of nitric oxide synthesis and protective role of insulin in acute thrombosis in vivo.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Glucose; Coronary Disease; Enzyme Inhibitors; Epoprostenol; Female; Insulin; Kinetics; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Thrombosis | 1999 |
Immobilised echistatin promotes platelet adhesion and protein tyrosine phosphorylation.
Topics: Adenosine Diphosphate; Alprostadil; Apyrase; Blood Platelets; Cell Adhesion; Cytochalasin D; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Integrins; Intercellular Signaling Peptides and Proteins; Maleimides; Peptides; Phosphorylation; Platelet Aggregation Inhibitors; Protein-Tyrosine Kinases; Tyrosine | 2000 |
Inhibition of induced and spontaneous platelet aggregation by destabilase from medicinal leech.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Cardiovascular Diseases; Collagen; Dose-Response Relationship, Drug; Endopeptidases; Fibrinolytic Agents; Humans; Leeches; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors | 2000 |
Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von willebrand factor interaction.
Topics: Actin Cytoskeleton; Actins; Adenosine Diphosphate; Alprostadil; Animals; Antibodies, Monoclonal; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; CHO Cells; Cricetinae; Cytochalasin D; Cytoskeleton; Depsipeptides; Humans; Mutagenesis, Site-Directed; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Stress, Mechanical; Thiazoles; Thiazolidines; Thrombasthenia; Transfection; von Willebrand Factor | 2000 |
Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Apyrase; Blood Platelets; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Radioligand Assay; Rats; Signal Transduction; Thionucleotides | 2001 |
Disaggregatory effects of prostaglandin E1, amrinone and milrinone on platelet aggregation in human whole blood.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Amrinone; Cardiotonic Agents; Collagen; Cyclic AMP; Dose-Response Relationship, Drug; Electrochemistry; Humans; Kinetics; Male; Middle Aged; Milrinone; Platelet Aggregation; Platelet Aggregation Inhibitors; Vasodilator Agents | 2000 |
Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets.
Topics: Actins; Adenosine Diphosphate; Alprostadil; Arsenicals; Blood Platelets; Calcium; Carbazoles; Cyclic AMP; Cyclic GMP; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitroprusside; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Protein Tyrosine Phosphatases; Pyrroles; Thapsigargin; Thrombin; Vanadates | 2001 |
Effects of sodium citrate, low molecular weight heparin, and prostaglandin E1 on aggregation, fibrinogen binding, and enumeration of equine platelets.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Anticoagulants; Blood Platelets; Calcium; Citrates; Fibrinogen; Fibrinolytic Agents; Flow Cytometry; Hematocrit; Heparin, Low-Molecular-Weight; Horses; Platelet Aggregation; Platelet Count; Sodium Citrate | 2001 |
Platelet activation by sustained exposure to low-dose plasmin.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Clot Retraction; Edetic Acid; Enzyme Inhibitors; Fibrinogen; Fibrinolysin; Humans; Phosphoinositide-3 Kinase Inhibitors; Platelet Activation; Platelet Factor 4; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Serotonin | 2001 |
Augmentation of receptor-mediated adenylyl cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gbetagamma subunit-independent manner.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Alprostadil; Animals; Calcium; Calmodulin; Cell Membrane; Chelating Agents; Cloning, Molecular; COS Cells; Cyclic AMP; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Pertussis Toxin; Prostaglandins; Prostaglandins E, Synthetic; Protein Structure, Tertiary; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Sulfonamides; Virulence Factors, Bordetella | 2002 |
Effect of diazepam and clonazepam on the function of isolated rat platelet and neutrophil.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Arachidonic Acid; Blood Platelets; Calcium Signaling; Clonazepam; Diazepam; Drug Interactions; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Platelet Activation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, GABA-A; Respiratory Burst; Thrombin | 2002 |
Activation-dependent surface expression of gC1qR/p33 on human blood platelets.
Topics: Adenosine Diphosphate; Alprostadil; Antibodies, Monoclonal; Blood Platelets; Carrier Proteins; Chlorides; Epinephrine; Flow Cytometry; Humans; Hyaluronan Receptors; Membrane Glycoproteins; Mitochondrial Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Protein Conformation; Proteins; Receptors, Complement; Receptors, Thrombin; Serotonin; Zinc Compounds | 2003 |
Quantitative analysis of platelet alpha v beta 3 binding to osteopontin using laser tweezers.
Topics: Abciximab; Adenosine Diphosphate; Alprostadil; Antibodies, Monoclonal; Blood Platelets; Humans; Immunoglobulin Fab Fragments; Integrin alphaVbeta3; Lasers; Oligopeptides; Osteopontin; Platelet Adhesiveness; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Sialoglycoproteins | 2003 |
Inhibition of ADP-induced intracellular Ca2+ responses and platelet aggregation by the P2Y12 receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E1.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Alprostadil; Calcium; Calcium Signaling; Clopidogrel; Cytoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Membrane Proteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Ticlopidine; Time Factors | 2004 |
Potentiation of antiaggregating effect of prostaglandins by alpha-tocopherol and quercetin.
Topics: Adenosine Diphosphate; Adult; alpha-Tocopherol; Alprostadil; Blood Platelets; Dose-Response Relationship, Drug; Drug Synergism; Epoprostenol; Female; Humans; Iloprost; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandins; Quercetin | 2004 |
Supportive evidence for altered platelet function in the dived rat.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Decompression Sickness; Disseminated Intravascular Coagulation; Diving; Male; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Rats; Rats, Sprague-Dawley | 1975 |
Stimulation of PGE receptors EP2 and EP4 protects cultured neurons against oxidative stress and cell death following beta-amyloid exposure.
Topics: Adenosine Diphosphate; Alprostadil; Amyloid beta-Peptides; Animals; Animals, Newborn; Blotting, Western; Cell Death; Cell Survival; Cerebral Cortex; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Neurons; Oxidative Stress; Peptide Fragments; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype | 2005 |
Loss of anti-aggregatory effects of aortic valve tissue in patients with aortic stenosis.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aortic Valve; Aortic Valve Insufficiency; Aortic Valve Stenosis; Biomarkers; Blood Platelets; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Female; Humans; Male; Middle Aged; Nitric Oxide; Platelet Aggregation; Platelet Aggregation Inhibitors; Research Design | 2006 |
The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite.
Topics: Adenosine Diphosphate; Alprostadil; Animals; Blood Platelets; Clopidogrel; Cyclic AMP; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Rats; Rats, Sprague-Dawley; Thiophenes; Ticlopidine | 2007 |
Dynamics of platelet functional recovery following a clopidogrel loading dose in healthy volunteers.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Clopidogrel; Drug Monitoring; Female; Humans; Male; Middle Aged; Platelet Aggregation Inhibitors; Point-of-Care Systems; Recovery of Function; Ticlopidine | 2008 |
Testing agonist-induced platelet aggregation by the Impact-R [Cone and plate(let) analyzer (CPA)].
Topics: Adenosine Diphosphate; Adult; Alprostadil; Arachidonic Acid; Blood Coagulation Disorders; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Ristocetin; Young Adult | 2008 |
Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Alprostadil; Antibodies, Monoclonal; Arachidonic Acid; Blood Platelets; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycoproteins; High-Throughput Screening Assays; Humans; Immunoglobulins; Integrin alpha2; Integrin beta3; Observer Variation; P-Selectin; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; S-Nitroso-N-Acetylpenicillamine | 2010 |
Decreased VASP phosphorylation in platelets of male and female smokers of young age.
Topics: Adenosine Diphosphate; Adult; Alprostadil; Blood Platelets; Cell Adhesion Molecules; Female; Humans; Male; Microfilament Proteins; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Smoking; Young Adult | 2010 |
Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Cytochrome P-450 CYP2C19; Diabetes Mellitus; Female; Genotype; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Risk Factors; Ticlopidine | 2013 |
Fractalkine activates a signal transduction pathway similar to P2Y12 and is associated with impaired clopidogrel responsiveness.
Topics: Adenosine Diphosphate; Alprostadil; Chemokine CX3CL1; Clopidogrel; Coronary Artery Disease; Humans; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Ticlopidine | 2012 |
Comparison of a new P2Y12 receptor specific platelet aggregation test with other laboratory methods in stroke patients on clopidogrel monotherapy.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Blood Platelets; Cell Adhesion Molecules; Clinical Laboratory Techniques; Clopidogrel; Female; Flow Cytometry; Humans; Male; Microfilament Proteins; Middle Aged; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Reproducibility of Results; Stroke; Ticlopidine | 2013 |
'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists.
Topics: Adenosine; Adenosine Diphosphate; Alprostadil; Biomarkers, Pharmacological; Blood Platelets; Bucladesine; Cell Adhesion Molecules; Cells, Cultured; Clopidogrel; Cyclic AMP; Humans; Iloprost; Microfilament Proteins; Phosphoproteins; Phosphorylation; Piperazines; Platelet Aggregation; Platelet Function Tests; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Reproducibility of Results; Sensitivity and Specificity; Thiophenes; Thrombophilia; Ticlopidine | 2014 |
Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastography.
Topics: Adenosine Diphosphate; Alprostadil; Clopidogrel; Drug Synergism; Humans; Platelet Aggregation; Platelet Function Tests; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombelastography; Ticlopidine | 2014 |
Detection of clopidogrel resistance using ADP induced aggregometry with specific inhibitor PGE1.
Topics: Adenosine Diphosphate; Adult; Aged; Alprostadil; Cardiovascular Diseases; Clopidogrel; Drug Resistance; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Ticlopidine; Treatment Outcome | 2014 |
Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography.
Topics: Adenosine Diphosphate; Alprostadil; Blood Platelets; Drug Synergism; Healthy Volunteers; Humans; In Vitro Techniques; Platelet Aggregation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thrombelastography | 2015 |
Developmental Differences in Platelet Inhibition Response to Prostaglandin E1.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Adult; Age Factors; Alprostadil; Blood Platelets; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Humans; Infant, Newborn; Platelet Aggregation | 2020 |
Comparison of acetylsalicylic acid and clopidogrel non-responsiveness assessed by light transmittance aggregometry and PFA-100® in patients undergoing neuroendovascular procedures.
Topics: Adenosine Diphosphate; Aged; Alprostadil; Aspirin; Blood Coagulation Tests; Blood Platelets; Clopidogrel; Collagen; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values; Reproducibility of Results; Stents; Technology Assessment, Biomedical; Thrombosis; Time Factors | 2020 |