adenosine diphosphate has been researched along with 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid in 188 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 43 (22.87) | 18.7374 |
| 1990's | 64 (34.04) | 18.2507 |
| 2000's | 51 (27.13) | 29.6817 |
| 2010's | 25 (13.30) | 24.3611 |
| 2020's | 5 (2.66) | 2.80 |
| Authors | Studies |
|---|---|
| Ahuja, M; Belmonte, E; Brass, LF; Cichowski, K; Hoxie, JA; Vassallo, RR | 1 |
| Cattaneo, M; Lecchi, A; Mannucci, PM; McGregor, JL; Randi, AM | 1 |
| Mayhan, WG | 3 |
| Dieter, JP; Komiotis, D; Le Breton, GC; Lim, CT; Venton, DL | 1 |
| Tatarintsev, AV; Varfolomeyev, SD; Vrzheshch, PV; Yershov, DE | 1 |
| Huang, SC; Huang, TF; Li, HL; Teng, CM; Wu, TS | 1 |
| Hall, DA; Hourani, SM; Nieman, CJ | 1 |
| Nakayama, K; Takeshita, N; Tanaka, Y; Watanabe, N; Yamazawa, T; Yanaihara, N | 1 |
| Inoue, M; Iwane, Y; Kobune, K; Kudo, T; Morikawa, M; Takanami, Y; Tsuboi, M | 1 |
| Ashmore, RC; McMurtry, IF; O'Brien, RF; Rodman, DM; Sato, K; Stelzner, TJ; Webb, SA | 1 |
| Hirano, K; Mizuno, A; Nagashima, S; Nakashima, M; Uematsu, T | 1 |
| Flick, JT; Kizer, J; Lazarchick, J; Singh, AK | 1 |
| Bult, H; Fret, HR; Herman, AG; Jordaens, FH | 1 |
| Brown, AM; Bund, S; Cooper, DG; Egan, JW; Hallam, TJ; Heagerty, AM; Hickey, DM; Kaumann, AJ; Keen, M; Merritt, JE | 1 |
| Lumley, P; Thomas, M | 1 |
| England, PJ; Hallam, TJ; Maguire, J; Moores, K; Murray, KJ; Reeves, ML; Rink, TJ; Simpson, AW | 1 |
| Burroughs, SF; Johnson, GJ | 1 |
| Keery, RJ; Lumley, P | 1 |
| Bevan, J; Heptinstall, S | 1 |
| Stürzebecher, S; Witt, W | 1 |
| Feller, DR; Kim, SU; Newman, HA; Romstedt, KJ; Witiak, DT | 1 |
| Keery, RJ; Lumley, P; Watts, IS | 1 |
| Bolton, JR; Cambridge, H; Sutherland, RJ | 1 |
| Prosdocimi, M; Zatta, A | 1 |
| Frojmovic, M; Pedvis, L; Wong, T | 1 |
| Kakushi, H; Shike, T; Uchida, K | 1 |
| Goldenberg, HJ; Harris, DN; Heran, CL; Michel, IM; Ogletree, ML; Phillips, MB | 1 |
| Brüne, B; Ullrich, V | 1 |
| Cerbone, AM; DiMinno, G; Mancini, M; Riccardi, G; Rivellese, A; Silver, MJ; Thiagarajan, P | 1 |
| Hamid-Bloomfield, S; Whittle, BJ | 1 |
| Myers, A; Ramwell, P; Torres Duarte, AP | 1 |
| Joseph, S; Kakkar, VV; Krishnamurthi, S | 1 |
| Jamaluddin, MP; Krishnan, LK | 1 |
| Faraci, FM; Heistad, DD; Mayhan, WG | 1 |
| Canciani, MT; Cattaneo, M; Lecchi, A; Mannuci, PM; Randi, AM | 1 |
| Moncada, S; Palmer, RM; Radomski, MW | 1 |
| Liakishev, AA; Mazurov, AV; Repin, VS; Sidorenko, BA; Sinitsyn, VE | 1 |
| Khashimov, KhA; Konovalov, GA; Mazurov, AV; Sinitsin, VE; Vedernikov, AIu | 1 |
| Page, CP; Robertson, DN | 1 |
| Daniel, JL; Morinelli, TA; Niewiarowski, S; Smith, JB | 1 |
| Bertelé, V; Castagnoli, MN; Cerletti, C; de Gaetano, G; Rajtar, G | 1 |
| Altman, R; Rouvier, J; Weisenberger, H | 1 |
| De Matteis, W; Del Principe, D; Di Corpo, ML; Di Giulio, S; Finazzi-Agro, A; Menichelli, A | 1 |
| Baird, A; Chamberlain, PD; Nunn, B | 1 |
| Leytin, VL; Mazurov, AV; Repin, VS; Tkachuk, VA | 1 |
| Hall, ER; Pan, IQ; Wu, KK | 1 |
| Kakkar, VV; Krishnamurthi, S; Westwick, J | 1 |
| Detwiler, TC; Huang, EM; McGowan, EB | 1 |
| Colman, RW; Figures, WR; Kornecki, E; Morinelli, TA; Niewiarowski, S; Wachtfogel, Y | 1 |
| Le Breton, GC; Parise, LV; Venton, DL | 2 |
| Catalano, PM; De Marco, L; Di Minno, G; Murphy, S; Shapiro, SS | 1 |
| Horwitz, PM; Kadowitz, PJ; Landry, AZ; Lippton, HL; McNamara, DB | 1 |
| Hochland, MC; Sanders, TA | 1 |
| Nunn, B | 1 |
| Harris, RH; Nichols, R; Ramwell, PW; Schmeling, JW | 1 |
| Chamberlain, PD; Nunn, B | 1 |
| Hallam, TJ; Ruggles, PA; Scrutton, MC; Wallis, RB | 1 |
| Feller, DR; Mayo, JR; Miller, DD; Navran, SS | 1 |
| Humphrey, PP; Lumley, P | 1 |
| Brodsky, I; Devlin, TM; McKenzie, RJ; Soslau, G | 1 |
| Barnard, MR; Bednarek, FJ; Ellis, PA; Kestin, AS; Michelson, AD; Rajasekhar, D | 1 |
| Chern, JW; Chou, TC; Ding, YA; Yen, MH | 1 |
| Daniel, JL; Gazzaniga, PP; Pulcinelli, FM; Riondino, S; Salganicoff, L | 1 |
| Bell, DR; Koritnik, DR; Koshy, A; Rensberger, HJ | 1 |
| Astarie-Dequeker, C; Devynck, MA; Korichneva, I | 1 |
| Edelman, ER; Friedman, M; Grossman, W; Harada, K; Sellke, FW; Simons, M; Wang, SY | 1 |
| Hirata, Y; Nakano, M; Nakashima, M; Uematsu, T; Umemura, K | 1 |
| Castiglioni, C; Gazzaniga, PP; Parisi, S; Pignatelli, P; Pulcinelli, FM; Riondino, S | 1 |
| Alagon, A; Donner, P; Haendler, B; Krätzschmar, J; Noeske-Jungblut, C; Possani, L; Schleuning, WD; Verhallen, P | 1 |
| Brooks, RM; Heistad, DD; Kaul, S; Padgett, RC; Waack, BJ | 1 |
| Escolar, G; Rao, GH; Smith, CM; White, JG | 1 |
| Geiger, J; Walter, U | 1 |
| Campagnoli, C; Crosignani, PG; Gatti, L; Gianotti, GA; Guarneri, D; Nicolini, U | 1 |
| Dai, HB; Friedman, M; Johnson, RG; Schoen, FJ; Sellke, FW; Shafique, T; Weintraub, RM | 1 |
| Boulanger, CM; Mombouli, JV; Vanhoutte, PM | 1 |
| Arabe, L; Parker, J; Pelleg, A; Soslau, G | 1 |
| Schrör, K; Verheggen, R | 1 |
| Cazenave, JP; Gachet, C; Laugwitz, KL; Nürnberg, B; Ohlmann, P; Schultz, G; Spicher, K | 1 |
| Dickinson, JP; Glenn, JR; Heptinstall, S; May, JA; Sanderson, HM; Wilcox, RG | 1 |
| Dangelmaier, C; Smith, JB; Zhou, Q | 1 |
| FitzGerald, GA; Praticò, D; Smyth, EM; Violi, F | 1 |
| Colman, RW; Puri, RN | 1 |
| Heptinstall, S; Lösche, W; Sanderson, HM; Vickers, J | 1 |
| Chiu, L; Faung, ST; Wang, CT | 1 |
| Lai, PS; Rodriguez, A; Spur, BW; Wong, PY; Yin, K | 1 |
| Caccamo, ML; Gatti, L; Gianotti, GA; Guarneri, D; Marini, A | 1 |
| Soslau, G; Youngprapakorn, D | 1 |
| Fein, A; Kapural, L | 1 |
| Akiba, K; Hayasaka, K; Katsuura, M; Mitsui, T; Shimizu, Y; Yokoyama, S | 1 |
| Batey, AJ; Coker, SJ; Shaw, LA | 1 |
| Brockbank, KG; Hansen, TN | 1 |
| Chang, YL; Hsueh, CM; Ko, FN; Lee, SS; Liu, KC; Teng, CM | 1 |
| Hashimoto, N; Hashimoto, Y; Kurokawa, K; Nakahara, K; Sato, H; Togo, M; Watanabe, T | 1 |
| Carroll, RC; Kouns, WC; Lanza, F; Steiner, B; Wang, XF | 1 |
| Feijge, MA; Heemskerk, JW; Hemker, HC; Henneman, L; Rosing, J | 1 |
| Brennecke, SP; Di Iulio, JL; Gude, NM; King, RG | 1 |
| Hangaishi, M; Hashimoto, Y; Ikari, Y; Kimura, S; Kurokawa, K; Miyata, T; Ohno, M; Taguchi, J; Togo, M; Watanabe, T | 1 |
| Coffman, TM; Hoffman, M; Koller, BH; Latour, A; Mannon, PJ; Mannon, RB; Oliver, JA; Smithies, O; Thomas, DW | 1 |
| Martinson, EA; Marx-Grunwitz, A; Presek, P; Scheible, S | 1 |
| Lages, B; Weiss, HJ | 1 |
| Ariga, T; Kobayashi, A; Kubota, K; Lim, H; Seki, T | 1 |
| Ozaki, Y; Satoh, K; Yang, L; Yatomi, Y | 1 |
| Alamanni, F; Biglioli, P; Colli, S; Foieni, F; Franzè, V; Gherli, T; Gianotti, GA; Guarnieri, D; Parolari, A; Stanghellini, M; Tantalo, V; Toscano, T; Tremoli, E | 1 |
| Kinlough-Rathbone, RL; Packham, MA; Perry, DW; Rand, ML | 1 |
| Chow, TW; Hellums, JD; Thiagarajan, P | 1 |
| Dangelmaier, C; Daniel, JL; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Casado, S; Farré, J; Gómez, J; Jiménez, A; López-Blaya, A; López-Farré, A; Montón, M; Núñez, A; Sánchez de Miguel, L; Zalba, LR | 1 |
| Asai, F; Koike, H; Ogawa, T; Sugidachi, A | 1 |
| Comunale, ME; Dai, HB; Gopal, A; Park, KW; Sellke, FW | 1 |
| Clatworthy, I; Jagroop, IA; Lewin, J; Mikhailidis, DP | 1 |
| Andrioli, G; Bellavite, P; Lussignoli, S; Minuz, P; Ortolani, R; Pincelli, S; Solero, P | 1 |
| Cameron, KE; Heptinstall, S; May, JA; Sanderson, HM; Storey, RF; White, AE | 1 |
| Altmann, C; Haude, M; Hermann, BL; Mann, K; Naber, C; Rosskopf, D; Siffert, W; Vietzke, D | 1 |
| Gabbeta, J; Kaplan, R; Mao, GF; Rao, AK; Sun, L | 1 |
| Dangelmaier, C; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Braun, M; Hermann, A; Rauch, BH; Schrör, K; Weber, AA | 1 |
| Cazenave, JP; Eckly, A; Gachet, C; Gendrault, JL; Hechler, B | 1 |
| Mahaut-Smith, MP; Mason, MJ | 1 |
| Durieux, ME; Gear, AR; Hollmann, MW; Hönemann, CW; Kohrs, R; Lo, B; Polanowska-Grabowska, RK | 1 |
| Akkerman, JW; den Dekker, E; Gorter, G; Heemskerk, JW; van der Vuurst, H | 1 |
| Balduini, C; Lova, P; Paganini, S; Sinigaglia, F; Torti, M | 1 |
| Comunale, ME; Dai, HB; Metais, C; Park, KW; Sellke, FW | 1 |
| Cho, MJ; Jackson, CW; Kent Gartner, T; Pestina, TI; Steward, SA | 1 |
| Gratacap, MP; Nieswandt, B; Offermanns, S; Schulte, V; Zywietz, A | 1 |
| Dangelmaier, C; Daniel, JL; Dorsam, RT; Jin, J; Kim, S; Kunapuli, SP; Quinton, TM | 1 |
| Dorsam, RT; Jin, J; Kim, S; Kunapuli, SP | 1 |
| Pears, CJ; Stafford, MJ; Watson, SP | 1 |
| Chen, W; Greco, NJ; Jamieson, GA; Luo, X; Shi, Y; Tonon, G | 1 |
| Handa, M; Ikeda, Y; Kadowaki, T; Koyasu, S; Matsubara, Y; Moroi, M; Nakajima, H; Oda, A; Suzuki, H; Terauchi, Y; Watanabe, N | 1 |
| Du, X; Gao, X; Le Breton, GC; Li, Z; Malik, AB; Zhang, G | 1 |
| Alberti, L; Bennardini, F; Di Simplicio, P; Franconi, F; Miceli, M; Rao, GH; Seghieri, G | 1 |
| Ikezawa, S; Isogaya, M; Miyamoto, M; Ohno, M; Otake, A; Suzuki, M; Umemura, K; Yamada, N | 1 |
| Bryckaert, M; Habib, A; Jandrot-Perrus, M; Pawlowski, M; Roger, S; Rosa, JP | 1 |
| Barrett, NE; Coffey, MJ; Coles, B; Gibbins, JM; Jarvis, GE; O'Donnell, VB; Wylie, OR | 1 |
| Fälker, K; Lange, D; Presek, P | 1 |
| Bény, JL | 1 |
| Du, X; Li, Z; Marjanovic, JA; Ruan, C; Zhang, G | 1 |
| Balduini, C; Bertoni, A; Campus, F; Lova, P; Sinigaglia, F; Torti, M | 1 |
| Boneu, B; Chatelain, N; Fiessinger, JN; Gaussem, P; Jude, B; Kroumova, M; Reny, JL; Thalamas, C | 1 |
| Bianchi, C; Feng, J; Li, J; Sandmeyer, JL; Sellke, FW | 1 |
| Cauwenberghs, S; Curvers, J; de Kort, W; Heemskerk, JW; Heeremans, J; Keuren, JF | 1 |
| Kamae, T; Kanakura, Y; Kashiwagi, H; Kato, H; Kurata, Y; Shiraga, M; Tadokoro, S; Tomiyama, Y | 1 |
| Bianchi, C; Boodhwani, M; Feng, J; Laham, R; Li, J; Mieno, S; Nakai, Y; Ramlawi, B; Sellke, FW; Voisine, P | 1 |
| Kahner, BN; Kunapuli, SP; Langan, S; Quinton, TM | 1 |
| Chung, JH; Han, HJ; Im, JH; Jin, YR; Kim, KN; Kim, TJ; Lee, JH; Lee, JJ; Lim, Y; Noh, JY; Park, ES; Park, JD; Seo, JM; Shin, KS; Wee, JJ; You, SH; Yu, JY; Yun, YP | 1 |
| Fujishiro, T; Honda, N; Ikeda, M; Ito, K; Ohnishi, K | 1 |
| Fox, SC; Heptinstall, S; White, AE; Wilcox, RG; Xavier, RG | 1 |
| Barton, JF; Hardy, AR; Mundell, SJ; Poole, AW | 1 |
| Cook, RJ; Hayward, CP; Heddle, NM; Liu, Y; McKay, H; Moffat, KA; Pai, M; Seecharan, J; Webert, KE | 1 |
| Kim, JM; Yun-Choi, HS | 1 |
| Brakebusch, C; Chrostek-Grashoff, A; Elvers, M; May, F; Nieswandt, B; Pleines, I; Pozgajova, M; Strehl, A; Varga-Szabo, D | 1 |
| Baldanzi, G; Balduini, C; Bernardi, B; Campus, F; Graziani, A; Guidetti, GF; Lova, P; Torti, M | 1 |
| Jin, J; Kim, JM; Koo, YK; Lee, YY; Park, S; Yun-Choi, HS | 1 |
| Eliautou, S; Gachet, C; Lanza, F; Mangin, PH; Walter, U | 1 |
| Chang, HC; Chou, HC; Fong, TH; Hsiao, G; Jayakumar, T; Lin, KH; Lu, WJ; Sheu, JR | 1 |
| Beckerman, J; Myers, A; Vicini, S; Young, JP | 1 |
| Khasawneh, FT; Murray, WJ; Ting, HJ | 1 |
| Khandoga, AL; Penz, SM; Schober, LJ; Siess, W | 1 |
| Broos, K; Deckmyn, H; Fontayne, A; Nurden, AT; Ruan, C; Salles, I; Szántó, T; Vanhoorelbeke, K | 1 |
| Brass, LF; Chatterjee, MS; Diamond, SL; Purvis, JE | 1 |
| Azumi, Y; Inatomi, S; Iwashita, M; Kikuchi, H; Kinugasa, S; Mori, K; Nakahata, N; Obara, Y; Oshima, Y | 1 |
| Kim, SY; Lee, JG; Lee, YJ; Lee, YY; Park, JH; Wu, B; Yun-Choi, HS | 1 |
| Armstrong, PC; Chan, MV; Jakubowski, JA; Kirkby, NS; Leadbeater, PD; Mitchell, JA; Warner, TD | 1 |
| Glusa, E; Görnemann, T; Jantschak, F; Kekewska, A; Pertz, HH | 1 |
| Espinosa, EV; Khasawneh, FT; Murad, JP; Ting, HJ | 1 |
| Brass, LF; Chatterjee, MS; Colace, TV; Diamond, SL; Flamm, MH; Jaeger, D; Jing, H; Sinno, T; Zhou, S | 1 |
| Ding, Z; Du, H; Liu, G; Pan, C; Wei, X; Ye, J; Zhang, S; Zhang, Y | 1 |
| Bianchi, C; Chu, LM; Clements, RT; Dobrilovic, N; Feng, J; Fingleton, JG; Liu, Y; Sellke, FW; Singh, AK | 1 |
| Chen, X; Li, D; Liu, J; Luo, X; Wang, K; Wang, Y; Wu, Y; Yang, Z; Zhang, L; Zhang, Y | 1 |
| Egoshi, M; Miyamoto, A; Shiraishi, M; Tamura, K | 1 |
| Diamond, SL; Jaeger, DT | 1 |
| Chu, C; Li, Q; Li, W; Liu, X; Ozaki, Y; Ren, L; Tang, X; Yi, W; Zhang, J; Zhu, L | 1 |
| Doi, T; Iida, H; Iida, Y; Kozawa, O; Matsushima-Nishiwaki, R; Ogura, S; Tokuda, H | 1 |
| Chen, L; Ding, Z; Hu, L; Ye, J; Zhai, L; Zhang, S; Zhang, Y | 1 |
| Chen, M; Chen, Y; Kong, Y; Ming, X; Su, W; Su, X; Wang, Y; Ye, X | 1 |
| Goggs, R; Harper, MT; Offermanns, S; Poole, AW; Walsh, TG; Williams, CM | 1 |
| Chen, X; Chu, S; Fang, W; Fei, Y; He, G; Li, Y; Wang, D; Wang, S; Wu, Q; Yang, L | 1 |
| Baker-Groberg, SM; Haley, KM; Lattimore, S; McCarty, OJ; Recht, M | 1 |
| Diamond, SL; Herbig, BA; Lee, MY; Verni, CC | 1 |
| Fu, H; Fu, J; Lu, H; Luo, Y; Ma, S; Wang, W; Xu, H; Zhang, Z; Zhu, X | 1 |
| Benson, DW; Bercovitz, RS; Cole, R; Moroi, A; Newman, DK; Newman, PJ; Niebler, RA; Scott, JP; Simpson, PM; Stuth, EAD; Woods, RK; Yan, K; Zwifelhofer, NMJ | 1 |
| Chaudhary, PK; Jee, Y; Kim, S; Lee, SH; Park, KM | 1 |
| Cardoso, CAL; Freitas de Lima, F; Lescano, CH; Mónica, FZ; Pires de Oliveira, I; Vieira, SCH | 1 |
| Bao, F; Dai, KS; Ge, XX; Ke, XY; Yan, R; Yang, MN; Ye, HL; Yuan, LX | 1 |
| Blaha, V; Carazo, A; Hrubša, M; Javorská, L; Karlíčková, J; Konečný, L; Krčmová, LK; Matoušová, K; Mladěnka, P; Musil, F; Paclíková, M; Parvin, MS; Skořepa, P; Šmahelová, A | 1 |
2 review(s) available for adenosine diphosphate and 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid
| Article | Year |
|---|---|
Properties and regulation of human platelet cation channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Cations; Humans; Inositol 1,4,5-Trisphosphate; Models, Biological; Prostaglandin Endoperoxides, Synthetic; Protein Kinases; Thrombin; Thromboxane A2; Type C Phospholipases; Vasoconstrictor Agents | 1993 |
Sex-Related Differences in Platelet Aggregation: A Literature Review Supplemented with Local Data from a Group of Generally Healthy Individuals.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Female; Humans; Lactones; Male; Platelet Aggregation; Platelet Aggregation Inhibitors | 2023 |
5 trial(s) available for adenosine diphosphate and 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid
| Article | Year |
|---|---|
Preliminary assessment of a novel thromboxane A2 receptor-blocking drug, GR32191, in healthy subjects.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Biphenyl Compounds; Dose-Response Relationship, Drug; Heptanoic Acids; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Single-Blind Method; Thromboxane A2 | 1990 |
Effect of temocillin and moxalactam on platelet responsiveness and bleeding time in normal volunteers.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Bleeding Time; Blood Platelets; Collagen; Humans; Male; Moxalactam; Penicillins; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic | 1985 |
A comparison of the influence on plasma lipids and platelet function of supplements of omega 3 and omega 6 polyunsaturated fatty acids.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Fatty Acids, Unsaturated; Female; Fish Oils; Humans; Lipids; Male; Oils; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane B2 | 1983 |
The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Aged; Arachidonic Acid; Area Under Curve; Collagen; Female; Humans; Kinetics; Male; Middle Aged; Naphthalenes; Platelet Aggregation; Platelet Aggregation Inhibitors; Propionates; Receptors, Thromboxane; Time Factors | 2005 |
Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Coagulation; Blood Platelets; Collagen; Diterpenes, Kaurane; Humans; Isodon; Male; Mice; Platelet Adhesiveness; Platelet Membrane Glycoproteins; Signal Transduction; Vasoconstrictor Agents | 2013 |
181 other study(ies) available for adenosine diphosphate and 15-hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic acid
| Article | Year |
|---|---|
Structure and function of the human platelet thrombin receptor. Studies using monoclonal antibodies directed against a defined domain within the receptor N terminus.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blood Platelets; Blotting, Western; Cell Line; Cell Membrane; Enzyme-Linked Immunosorbent Assay; Epinephrine; Humans; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Receptors, Thrombin; Thrombin; Trypsin; Vasoconstrictor Agents | 1992 |
Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Clot Retraction; Collagen; Cyclic AMP; Epinephrine; Fibrinogen; Hemorrhage; Humans; Indomethacin; Kinetics; Male; Middle Aged; Platelet Activating Factor; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Reference Values; Thrombin; Vasoconstrictor Agents; von Willebrand Factor | 1992 |
Effect of diabetes mellitus on responses of the basilar artery in rats to products released by platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Basilar Artery; Blood Platelets; Cerebrovascular Disorders; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Serotonin; Vasodilation | 1992 |
PgH2 analogs as potential antiplatelet derivatives.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Cells, Cultured; Humans; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Structure-Activity Relationship | 1992 |
Cell response kinetics: the phenomenon of supercooperativity in aggregation of human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Calcimycin; Epinephrine; Humans; Kinetics; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Tetradecanoylphorbol Acetate; Thimerosal | 1992 |
Antiplatelet actions of some coumarin compounds isolated from plant sources.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Coumarins; Membrane Lipids; Molecular Structure; Phospholipids; Plants; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thrombin; Thromboxane B2 | 1992 |
Responses of cerebral arterioles during chronic ethanol exposure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Alcoholism; Animals; Arterioles; Blood Pressure; Cerebrovascular Circulation; Histamine; Male; Nitroglycerin; Pia Mater; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Reference Values; Vasodilation | 1992 |
Effects of the P2-purinoceptor antagonist, suramin, on human platelet aggregation induced by adenosine 5'-diphosphate.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Humans; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic; Serotonin; Suramin | 1992 |
Effects of porcine galanin on the mesenteric microcirculation and arteriolar smooth muscle in the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Agglutination; Animals; Arterioles; Erythrocytes; Galanin; Glyburide; Guanidines; In Vitro Techniques; Isometric Contraction; Male; Microcirculation; Muscle, Smooth, Vascular; Peptides; Pinacidil; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Splanchnic Circulation; Swine; Vasodilator Agents | 1991 |
Effects of combination therapy with low-dose aspirin and warfarin on platelet functions after heart valve replacement.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aged; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Calcium; Collagen; Drug Therapy, Combination; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Thromboembolism; Ticlopidine; Warfarin | 1991 |
Paradoxical constriction to platelets by arteries from rats with pulmonary hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Aorta; Blood Platelets; Calcimycin; Cardiomegaly; Endothelium, Vascular; Hypertension, Pulmonary; Male; Meclofenamic Acid; Nitroprusside; Platelet Aggregation; Platelet Storage Pool Deficiency; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Rats; Rats, Inbred Strains; Serotonin; Vasoconstriction; Vasodilation | 1991 |
Pharmacokinetic and pharmacodynamic profiles of vapiprost, a selective, long-lasting thromboxane receptor antagonist, after single and multiple oral administration to healthy volunteers.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Adult; Biphenyl Compounds; Collagen; Drug Administration Schedule; Heptanoic Acids; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2 | 1991 |
Platelet dysfunction in Noonan's syndrome. A case with a platelet cyclooxygenase-like deficiency and chronic idiopathic thrombocytopenic purpura.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acids; Blood Platelets; Chronic Disease; Collagen; Epinephrine; Female; Humans; Noonan Syndrome; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Purpura, Thrombocytopenic | 1991 |
Responses of the basilar artery to products released by platelets during chronic hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Basilar Artery; Blood Platelets; Hypertension; Male; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Vasodilation | 1991 |
Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Dipyridamole; Drug Synergism; Epoprostenol; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Phenylephrine; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Vasodilation | 1991 |
Primate vascular responses to octimibate, a non-prostanoid agonist at the prostacyclin receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Humans; Imidazoles; In Vitro Techniques; Lung; Macaca fascicularis; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Receptors, Epoprostenol; Receptors, Prostaglandin; Sterol O-Acyltransferase | 1991 |
The effects of siguazodan, a selective phosphodiesterase inhibitor, on human platelet function.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Calcium; Chromatography, Ion Exchange; Collagen; Cyclic AMP; Guanidines; Humans; In Vitro Techniques; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prostaglandin Endoperoxides, Synthetic; Pyridazines | 1990 |
Beta-lactam antibiotic-induced platelet dysfunction: evidence for irreversible inhibition of platelet activation in vitro and in vivo after prolonged exposure to penicillin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Carbon Radioisotopes; Collagen; Epinephrine; Humans; In Vitro Techniques; Kinetics; Mezlocillin; Oxacillin; Penicillins; Platelet Activation; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Radioisotope Dilution Technique; Serotonin | 1990 |
AH6809, a prostaglandin DP-receptor blocking drug on human platelets.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Adenosine Diphosphate; Adenosine-5'-(N-ethylcarboxamide); Dinoprost; Epoprostenol; Humans; Hydantoins; In Vitro Techniques; Male; Platelet Activating Factor; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Receptors, Immunologic; Receptors, Prostaglandin; Xanthenes; Xanthones | 1988 |
How can we inhibit 5-HT-induced platelet aggregation and why should we bother?
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amlodipine; Female; Humans; Male; Middle Aged; Nifedipine; Platelet Activating Factor; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin Antagonists; Verapamil | 1988 |
The PGI2-analogue iloprost and the TXA2-receptor antagonist sulotroban synergistically inhibit TXA2-dependent platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Drug Synergism; Epoprostenol; Fatty Acids, Unsaturated; Humans; Hydrazines; Iloprost; In Vitro Techniques; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides | 1988 |
Potent antiplatelet effects of cyclic clofibric acid (CPIB) analogs on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Benzopyrans; Chromans; Clofibrate; Clofibric Acid; Epinephrine; Humans; Malondialdehyde; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1989 |
Differential ability of agonists to express distinct pools of fibrinogen (GpIIb/IIIa) receptors which can mediate the aggregation of human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Antibodies, Monoclonal; Collagen; Egtazic Acid; Epinephrine; Humans; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Temperature | 1989 |
Functional and morphological studies on blood platelets in a thrombasthenic horse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelet Disorders; Blood Platelets; Calcimycin; Collagen; Epistaxis; Female; Horse Diseases; Horses; Male; Microscopy, Electron; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Serotonin; Thrombasthenia | 1989 |
Platelet activation induced by a stable analogue of endoperoxides (U46619)
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; beta-Thromboglobulin; Blood Platelets; Fibrinogen; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1989 |
Platelet size affects both micro- and macro-aggregation: contributions of platelet number, volume fraction and cell surface.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Blood Platelets; Cell Membrane; Cell Separation; Humans; Kinetics; Microscopy, Phase-Contrast; Nephelometry and Turbidimetry; Platelet Activating Factor; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Ristocetin | 1989 |
[Effect of a new thromboxane A2 antagonist, S-145, on platelet aggregation].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Adult; Animals; Arachidonic Acids; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Collagen; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Guinea Pigs; Humans; Hydrazines; In Vitro Techniques; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Rabbits; Thromboxane A2 | 1989 |
Antithrombotic effects of the thromboxane A2 antagonist, SQ 28,668, in vitro and in the coronary circulation in vivo.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Coronary Circulation; Cyclic AMP; Fibrinolytic Agents; Humans; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Species Specificity; Swine; Thromboxane A2; Thromboxane-A Synthase | 1988 |
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Carbon Monoxide; Cyclic GMP; Enzyme Activation; Epinephrine; Epoprostenol; Guanylate Cyclase; Humans; In Vitro Techniques; Nitroprusside; Phospholipids; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane B2 | 1987 |
Increased binding of fibrinogen to platelets in diabetes: the role of prostaglandins and thromboxane.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Antibodies, Monoclonal; Binding Sites, Antibody; Binding, Competitive; Blood Platelets; Collagen; Diabetes Mellitus, Type 1; Female; Fibrinogen; Humans; In Vitro Techniques; Male; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Receptors, Cell Surface; Thromboxane B2 | 1985 |
Prostaglandin D2 interacts at thromboxane receptor-sites on guinea-pig platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Guinea Pigs; Male; Organophosphonates; Organophosphorus Compounds; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Prostanoic Acids; Receptors, Cell Surface; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides | 1986 |
Sex differences in mouse platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Female; Hematocrit; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Sex Characteristics | 1986 |
Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Collagen; Epinephrine; Humans; In Vitro Techniques; Kinetics; Male; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Serotonin; Tetradecanoylphorbol Acetate; Thrombin | 1987 |
Conformational responses of an arachidonate- and U46619-binding haemoprotein in relation to platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Carrier Proteins; Cattle; Cold Temperature; Hemeproteins; Immunodiffusion; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Conformation; Spectrophotometry | 1987 |
Responses of cerebral arterioles to adenosine 5'-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arterioles; Brain; Chronic Disease; Hypertension; Indomethacin; Male; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Vasodilation | 1988 |
Role of ADP in platelet aggregation and fibrinogen binding induced by prostaglandin endoperoxides: studies in a patient with a selective defect of ADP-induced platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Antigens, Differentiation; Binding, Competitive; Fibrinogen; Humans; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic | 1988 |
Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Biological Products; Blood Platelets; Collagen; Endothelium, Vascular; Epoprostenol; Humans; In Vitro Techniques; Indicators and Reagents; Nitric Oxide; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Swine; Thrombin | 1987 |
[Increased adhesive and aggregation activity of the platelets of ischemic heart disease patients with stable stenocardia].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angina Pectoris; Coronary Disease; Humans; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1987 |
[Thrombocyte function during the performance of plasmapheresis and immunosorption in patients with familial hypercholesterolemia].
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Blood Platelets; Female; Hemoperfusion; Heterozygote; Humans; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Male; Middle Aged; Plasmapheresis; Platelet Adhesiveness; Platelet Aggregation; Platelet Count; Prostaglandin Endoperoxides, Synthetic; Time Factors | 1987 |
Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Collagen; Female; Guinea Pigs; In Vitro Techniques; Indium Radioisotopes; Male; Platelet Activating Factor; Prostaglandin Endoperoxides, Synthetic; Respiratory System | 1987 |
Receptor-mediated effects of a PGH2 analogue (U 46619) on human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Humans; Kinetics; Myosin-Light-Chain Kinase; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Serotonin; Sulfonamides | 1987 |
Prostaglandins and human platelet aggregation. Implications for the anti-aggregating activity of thromboxane-synthase inhibitors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Dinoprost; Dinoprostone; Drug Synergism; Humans; Imidazoles; Oxidoreductases; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Prostanoic Acids; Thromboxane B2; Thromboxane-A Synthase | 1985 |
Identification of platelet inhibitor present in the melon (Cucurbitacea cucumis melo).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Collagen; Epinephrine; Fruit; Humans; Kinetics; Plant Extracts; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombin | 1985 |
Hydrogen peroxide has a role in the aggregation of human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amitrole; Catalase; Collagen; Humans; Hydrogen Peroxide; Mucocutaneous Lymph Node Syndrome; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Tetradecanoylphorbol Acetate; Thrombin; Zymosan | 1985 |
Decrease of platelet aggregation and spreading via inhibition of the cAMP phosphodiesterase by trapidil.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cyclic AMP; Epoprostenol; Humans; Platelet Adhesiveness; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Pyrimidines; Theophylline; Thrombin; Trapidil | 1984 |
Alteration of platelet responses to metabolites of arachidonic acid by oral contraceptives.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Contraceptives, Oral; Contraceptives, Oral, Synthetic; Cyclic AMP; Epoprostenol; Female; Humans; Platelet Aggregation; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins D; Thromboxane A2; Thromboxane B2 | 1984 |
Regulation of human platelet activation--analysis of cyclooxygenase and cyclic AMP-dependent pathways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcimycin; Collagen; Cyclic AMP; Epinephrine; Epoprostenol; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Serotonin; Thrombin; Thromboxane B2 | 1984 |
Succinate potentiates the action of platelet agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Binding, Competitive; Cyclic AMP; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Monensin; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Succinates | 1984 |
Platelet aggregation and exposure of fibrinogen receptors by prostaglandin endoperoxide analogues.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Dose-Response Relationship, Drug; Fibrinogen; Iodine Radioisotopes; Platelet Aggregation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Receptors, Cell Surface | 1983 |
Prostacyclin potentiates 13-azaprostanoic acid-induced platelet deaggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Cyclic AMP; Drug Synergism; Epoprostenol; Fatty Acids; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Prostanoic Acids | 1982 |
The role of ADP secretion and thromboxane synthesis in factor VIII binding to platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Factor VIII; Humans; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2; Thromboxanes | 1983 |
Influence of verapamil and diltiazem on aggregatory responses in cat and rabbit platelet rich plasma.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Benzazepines; Calcium Channel Blockers; Cats; Diltiazem; Female; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Rabbits; Verapamil | 1984 |
Total and selective desensitisation of human platelets to synthetic platelet activating factor (PAF): evidence that extracellular PAF does not mediate collagen-induced aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Collagen; Dose-Response Relationship, Drug; Extracellular Space; Humans; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1983 |
Thromboxane A2 and the endoperoxides mediate canine platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Dogs; Dose-Response Relationship, Drug; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins E; Prostaglandins F; Thromboxane A2; Thromboxane B2; Thromboxanes | 1981 |
Further evidence against the validity of using an ADP-removing enzyme system (CP/CPK) for demonstrating the role of secreted ADP in platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Creatine Kinase; In Vitro Techniques; Mice; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic | 1983 |
Thromboxane A2/prostaglandin H2 directly stimulates platelet shape change independent of secreted ADP.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Humans; In Vitro Techniques; Prostaglandin Endoperoxides; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Thromboxane A2; Thromboxanes | 1982 |
Desensitisation in human and rabbit blood platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arginine Vasopressin; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Serotonin; Tachyphylaxis; Thrombin | 1982 |
Stereo-dependent inhibition of human platelet function by the optical isomers of trimetoquinol.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Humans; In Vitro Techniques; Isoquinolines; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Stereoisomerism; Thromboxane A2; Tretoquinol | 1981 |
A method for quantitating platelet aggregation and analyzing drug-receptor interactions on platelets in whole blood in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Aspirin; Blood Cell Count; Blood Platelets; Epinephrine; Guinea Pigs; In Vitro Techniques; Phentolamine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Drug; Time Factors | 1981 |
Extracellular ATP inhibits agonist-induced mobilization of internal calcium in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Calcium; Collagen; Creatine Kinase; Humans; Kinetics; Nucleotides; Phosphocreatine; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic P2; Thrombin; Thromboxane A2 | 1995 |
Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aging; Epinephrine; Female; Flow Cytometry; Humans; Infant, Newborn; Male; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2 | 1994 |
Antiplatelet actions of 2-(4-[1-(2-chlorophenyl) piperazinyl]) methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one compound.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Blood Platelets; Calcium; Collagen; Cyclic AMP; Epinephrine; Fibrinogen; Humans; Imidazoles; Pancreatic Elastase; Phosphatidylinositols; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinazolines; Rabbits; Receptors, Cell Surface; Signal Transduction; Thromboxane A2; Thromboxane B2 | 1995 |
Fibrinogen binding is independent of an increase in intracellular calcium concentration in thrombin degranulated platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Cell Degranulation; Evaluation Studies as Topic; Fibrinogen; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Protein Binding; Receptors, Thromboxane; Thromboxane A2; Thromboxanes | 1995 |
Estrogen pretreatment directly potentiates endothelium-dependent vasorelaxation of porcine coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arginine; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Nitroglycerin; Orchiectomy; Prostaglandin Endoperoxides, Synthetic; Reference Values; Sex Characteristics; Swine; Tamoxifen; Thromboxane A2; Vasoconstrictor Agents; Vasodilation | 1995 |
Different effects of endothelin-3 on the Ca2+ discharge induced by agonists and Ca(2+)-ATPase inhibitors in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Antioxidants; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Agonists; Calcium-Transporting ATPases; Endothelins; Fatty Acids, Unsaturated; Fura-2; Humans; Hydrazines; Hydroquinones; In Vitro Techniques; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Endothelin; Receptors, Thromboxane; Terpenes; Thapsigargin; Thrombin; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Alginates; Animals; Arginine; Calcimycin; Coronary Circulation; Coronary Vessels; Drug Carriers; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Glucuronic Acid; Heart; Hexuronic Acids; Indomethacin; Ketanserin; Male; Microcirculation; Muscle Relaxation; Myocardial Infarction; Myocardium; Nitroarginine; Nitroprusside; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Sepharose; Serotonin; Swine; Thromboxane A2; Vasodilation | 1994 |
Enhancement of thrombotic arterial occlusion following cholesterol feeding in the guinea-pig: a role for thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arterial Occlusive Diseases; Cholesterol, Dietary; Collagen; Femoral Artery; Guinea Pigs; Male; Photochemistry; Platelet Activating Factor; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thrombosis; Thromboxane A2; Time Factors | 1994 |
Effect of picotamide on the calcium mobilization and phospholipase C activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Aspirin; Blood Platelets; Calcium; Chromatography, Gel; Enzyme Activation; Humans; In Vitro Techniques; Phthalic Acids; Platelet Activation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Thrombin; Thromboxane A2; Type C Phospholipases | 1994 |
An inhibitor of collagen-induced platelet aggregation from the saliva of Triatoma pallidipennis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; Base Sequence; Blood Platelets; Cell Line; Collagen; Cricetinae; Gene Expression; Humans; Kidney; Kinetics; Molecular Sequence Data; Molecular Weight; Phorbol Esters; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Recombinant Proteins; Saliva; Salivary Proteins and Peptides; Thrombin; Thromboxane A2; Transfection; Triatominae | 1994 |
Interaction of human platelets and leukocytes in modulation of vascular tone.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Arginine; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Carotid Artery, Common; Ergolines; Fatty Acids, Unsaturated; Humans; Hydrazines; In Vitro Techniques; Muscle Tonus; Muscle, Smooth, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nitroarginine; Nitroprusside; Phenylephrine; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Receptors, Thromboxane; Serotonin Antagonists; Superoxide Dismutase; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
Influence of heat on platelet biochemistry, structure, and function.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Animals; Aorta; Arachidonic Acid; Blood Platelets; Blood Proteins; Calcium; Collagen; Cytoskeleton; Endothelium, Vascular; Epinephrine; Hot Temperature; Humans; In Vitro Techniques; Kinetics; Microscopy, Electron; Muscle, Smooth, Vascular; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Rabbits; Serotonin; Thrombin; Time Factors | 1993 |
Maternal and fetal platelet activation in normal pregnancy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Female; Fetal Blood; Fetus; Humans; Platelet Activation; Pregnancy; Prostaglandin Endoperoxides, Synthetic; Regression Analysis; Thromboxane A2 | 1994 |
Mechanisms causing coronary microvascular dysfunction following crystalloid cardioplegia and reperfusion.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Calcimycin; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Vessels; Endocardium; Endothelium, Vascular; Female; Heart Arrest, Induced; Male; Microcirculation; Microscopy, Electron; Muscle, Smooth, Vascular; Myocardial Reperfusion; Pericardium; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Swine; Thromboxane A2; Vasodilation | 1993 |
Indapamide inhibits endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Aorta, Thoracic; Endothelium, Vascular; Hypertension; In Vitro Techniques; Indapamide; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred SHR; Receptors, Thromboxane; Thromboxane A2 | 1993 |
Aggregation of human and canine platelets: modulation by purine nucleotides.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine Nucleotides; Adenosine Diphosphate; Animals; Collagen; Dogs; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic; Receptors, Thromboxane; Thrombin; Thromboxane A2 | 1993 |
Effect of naftidrofuryl on platelet-induced vasospasm in vitro. Role of antiserotonergic actions.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Coronary Vessels; Dinoprost; Humans; In Vitro Techniques; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Nafronyl; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Serotonin Antagonists; Thromboxanes; Vasoconstrictor Agents | 1993 |
The human platelet ADP receptor activates Gi2 proteins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Affinity Labels; Azides; Blood Platelets; Cyclic AMP; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Immunosorbent Techniques; Photochemistry; Prostaglandin Endoperoxides, Synthetic; Receptors, Purinergic P2; Thrombin; Thromboxane A2 | 1995 |
Effects of ticlopidine administered to healthy volunteers on platelet function in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Cells, Cultured; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Ticlopidine | 1995 |
The hemorrhagin catrocollastatin inhibits collagen-induced platelet aggregation by binding to collagen via its disintegrin-like domain.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amino Acid Sequence; Blood Platelets; Collagen; Crotalid Venoms; Disintegrins; Humans; In Vitro Techniques; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Peptides; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Protein Binding; Sequence Homology, Amino Acid; Thromboxane A2; Tritium | 1996 |
Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line; Collagen; Dinoprost; F2-Isoprostanes; Fatty Acids, Unsaturated; Humans; In Vitro Techniques; Inositol Phosphates; Kidney; Kinetics; Pertussis Toxin; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Radioligand Assay; Receptors, Thromboxane; Recombinant Proteins; Thrombin; Thromboxane A2; Transfection; Virulence Factors, Bordetella | 1996 |
Inhibition of ADP-induced platelet activation by 7-chloro-4-nitrobenz-2-oxa-1,3-diazole: covalent modification of aggregin, a putative ADP receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Chloro-7-nitrobenzofurazan; Adenosine; Adenosine Diphosphate; Blood Platelets; Calcimycin; Calcium; Cell Aggregation; Cell Size; Collagen; Cyclic AMP; Fibrinogen; Humans; Platelet Activation; Platelet Membrane Glycoproteins; Prostaglandin Endoperoxides, Synthetic; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2; Time Factors | 1996 |
Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Azepines; Blood Platelets; Humans; In Vitro Techniques; Piperazines; Piperidines; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Serotonin; Succinates; Sulfonamides; Thromboxane A2; Triazoles; Vasoconstrictor Agents | 1996 |
Platelet lysis and functional perturbation by 13-methyl myristate. The major fatty acid in Flavobacterium ranacida.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Cell Membrane; Collagen; Fibrinogen; Flavobacterium; Humans; Microscopy, Electron, Scanning; Myristic Acids; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Tetradecanoylphorbol Acetate; Thrombin; Thromboxane A2 | 1996 |
Antithrombotic effects of peroxynitrite: inhibition and reversal of aggregation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Cyclic GMP; Humans; Nitrates; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Spectrophotometry; Thrombin; Thromboxane A2 | 1995 |
Platelet activation in newborns detected by flow-cytometry.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aging; Antibodies, Monoclonal; Female; Flow Cytometry; Humans; Infant, Newborn; Male; Platelet Activation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2 | 1996 |
A possible dual physiological role of extracellular ATP in the modulation of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Chromatography, High Pressure Liquid; Collagen; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thrombin; Thromboxane A2 | 1997 |
Suppression of the voltage-gated K+ current of human megakaryocytes by thrombin and prostacyclin.
Topics: 1-Methyl-3-isobutylxanthine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Bone Marrow; Colforsin; Cyclic AMP; Egtazic Acid; Enzyme Inhibitors; Epoprostenol; GTP-Binding Proteins; Humans; Ion Channel Gating; Megakaryocytes; Membrane Potentials; Patch-Clamp Techniques; Peptide Fragments; Peptides; Platelet Aggregation Inhibitors; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Receptors, Thrombin; Thrombin; Thromboxane A2 | 1997 |
Defective signal transduction through the thromboxane A2 receptor in a patient with a mild bleeding disorder: deficiency of the inositol 1,4,5-triphosphate formation despite normal G-protein activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelet Disorders; Blood Platelets; Calcimycin; Child; Female; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Receptors, Thromboxane; Signal Transduction; Thrombin; Thromboxane A2; Type C Phospholipases | 1997 |
Combined administration of 5-HT2 and thromboxane A2 antagonists: effects on platelet aggregation and isolated cardiac muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Pressure; Dioxanes; Electrocardiography; Heart; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinolines; Rats; Rats, Wistar; Refractory Period, Electrophysiological; Serotonin Antagonists; Thromboxane A2; Vasoconstrictor Agents | 1997 |
Increased platelet aggregation due to chilling to 20 degrees C is not related to increased sensitivity to agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Analysis of Variance; Arachidonic Acid; Blood Platelets; Cold Temperature; Humans; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Thromboxane B2; Vasoconstrictor Agents | 1997 |
Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aporphines; Arachidonic Acid; Blood Platelets; Collagen; Cyclic AMP; Guaiacol; Humans; Isoquinolines; Isotope Labeling; Lipoxygenase Inhibitors; Male; Phenanthrenes; Platelet Activating Factor; Platelet Aggregation Inhibitors; Quinolines; Rabbits; Radioimmunoassay; Structure-Activity Relationship; Thrombin; Thromboxane B2; Vasoconstrictor Agents | 1997 |
Characteristics of protein kinase C-independent exocytosis in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Aspirin; Blood Platelets; Exocytosis; Humans; Indoles; Maleimides; Molecular Weight; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Thromboxane B2; Vasoconstrictor Agents | 1997 |
Blocking platelet aggregation inhibits thromboxane A2 formation by low dose agonists but does not inhibit phosphorylation and activation of cytosolic phospholipase A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Adenosine Diphosphate; Blood Platelets; Cytoplasmic Granules; Cytosol; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Lysophospholipids; Peptide Fragments; Phosphorylase a; Phosphorylation; Plasma; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Serotonin; Thrombasthenia; Thromboxane A2; Tyrosine; Vasoconstrictor Agents | 1997 |
The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apyrase; Aspirin; Blood Platelets; Calcium; Cytosol; Egtazic Acid; Humans; In Vitro Techniques; Kinetics; Peptide Fragments; Platelet Activation; Receptors, Thrombin; Signal Transduction; Thrombin; Time Factors | 1997 |
Effects of ATP, ADP, thrombin, vasopressin and U46619 on human placental nitric oxide synthase activity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arginine; Chromatography, Thin Layer; Citrulline; Female; Hemostatics; Humans; In Vitro Techniques; Nitric Oxide Synthase; Nitroarginine; Placenta; Thrombin; Vasoconstrictor Agents; Vasopressins | 1997 |
Increased aggregation of human platelets produced by advanced glycation end products in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arginine; Arteriosclerosis; Cyclic AMP; Cyclic GMP; Female; Glycation End Products, Advanced; Humans; Indomethacin; Lysine; Male; Oxidative Stress; Platelet Aggregation; Polylysine; Prostaglandins; Reactive Oxygen Species; Serum Albumin, Bovine; Superoxide Dismutase; Superoxides | 1998 |
Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Bleeding Time; Blood Coagulation Disorders; Collagen; Female; Hemodynamics; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thromboxane; Shock; Thromboxane A2 | 1998 |
Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Blood Platelets; Blood Proteins; Enzyme Activation; Fibrinogen; Humans; Phospholipase D; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Purinergic Antagonists; Receptors, Thromboxane; Signal Transduction; Thionucleotides; Thrombin | 1998 |
Secreted dense granule adenine nucleotides promote calcium influx and the maintenance of elevated cytosolic calcium levels in stimulated human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Blood Platelets; Calcium; Cytoplasmic Granules; Cytosol; Drug Interactions; Fura-2; Humans; Ion Transport; Platelet Activation; Platelet Storage Pool Deficiency; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2X; Thrombin | 1999 |
Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Blood Coagulation Factors; Collagen; Hemostatics; Hexanes; Inhibitory Concentration 50; Octanes; Plant Extracts; Plants, Edible; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfur Compounds; Thrombin; Trees; Vasoconstrictor Agents | 1999 |
Inhibitory effects of beraprost on platelet aggregation: comparative study utilizing two methods of aggregometry.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Binding Sites; Blood Platelets; Cholesterol; Collagen; Dose-Response Relationship, Drug; Down-Regulation; Epinephrine; Epoprostenol; Humans; Iodine Radioisotopes; Lipoproteins, HDL; Methods; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Count; Protein Kinase C; Scattering, Radiation; Vasoconstrictor Agents | 1999 |
Platelet function and anesthetics in cardiac surgery: an in vitro and ex vivo study.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Aged; Anesthetics, Intravenous; Blood Platelets; Cardiac Surgical Procedures; Female; Humans; Male; Middle Aged; P-Selectin; Platelet Glycoprotein GPIIb-IIIa Complex; Thiopental | 1999 |
Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Anti-Bacterial Agents; Blood Platelets; Cathepsin G; Cathepsins; Drug Interactions; Hemostatics; Humans; Platelet Activating Factor; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Ristocetin; Serine Endopeptidases; Serotonin; Thrombin; Vasoconstrictor Agents | 1999 |
Thrombin receptor activating peptide (SFLLRN) potentiates shear-induced platelet microvesiculation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Coagulation; Blood Platelets; Cell Membrane; Cell Separation; Collagen; Crotalid Venoms; Drug Synergism; Epinephrine; Flow Cytometry; Humans; Peptide Fragments; Platelet Activation; Receptors, Thrombin; Stress, Mechanical | 2000 |
The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aspirin; Blood Platelets; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Platelet Activation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2000 |
Comparative effects of angiotensin II AT-1-type receptor antagonists in vitro on human platelet activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Angiotensin II; Angiotensin Receptor Antagonists; Antibodies, Monoclonal; Benzimidazoles; Benzoates; Binding, Competitive; Biphenyl Compounds; Blood Platelets; Dose-Response Relationship, Drug; Humans; Imidazoles; Irbesartan; Losartan; Platelet Activation; Pyridines; Radioligand Assay; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Telmisartan; Tetrazoles; Thromboxane A2; Time Factors; Valine; Valsartan | 2000 |
Reduced platelet serotonin content in rabbits with dietary hypercholesterolemia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosphate; Animals; Blood Platelets; Cholesterol, Dietary; Free Radical Scavengers; Hypercholesterolemia; Platelet Aggregation; Rabbits; Serotonin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2000 |
Dilation by isoflurane of preconstricted, very small arterioles from human right atrium is mediated in part by K(+)-ATP channel opening.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Anesthetics, Inhalation; Arterioles; Atrial Appendage; Coronary Disease; Coronary Vessels; Humans; In Vitro Techniques; Isoflurane; Middle Aged; Nitroprusside; Potassium Channels; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2000 |
Shape change in human platelets: measurement with a channelyzer and visualisation by electron microscopy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Cell Size; Epinephrine; Humans; Microscopy, Electron; Platelet Count; Platelet Function Tests; Pseudopodia; Serotonin; Time Factors | 2000 |
Defective platelet response to arachidonic acid and thromboxane A(2) in subjects with Pl(A2) polymorphism of beta(3) subunit (glycoprotein IIIa).
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; beta-Thromboglobulin; Blood Platelets; Coronary Disease; Female; Flow Cytometry; Genotype; Humans; Male; Middle Aged; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Platelet Glycoprotein GPIIb-IIIa Complex; Polymorphism, Genetic; Risk Factors; Statistics, Nonparametric; Thrombin; Thromboxane A2 | 2000 |
The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Analysis of Variance; Annexin A5; Aspirin; Blood Platelets; Calcium; Collagen; Cytosol; Fibrinolytic Agents; Flow Cytometry; Humans; Membrane Proteins; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serotonin; Stimulation, Chemical; Thromboxane A2 | 2000 |
Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenylate Cyclase Toxin; Adolescent; Adult; Alleles; Colforsin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Epinephrine; Heterotrimeric GTP-Binding Proteins; Humans; In Vitro Techniques; Isoenzymes; Male; Membrane Proteins; P-Selectin; Pertussis Toxin; Platelet Aggregation; Polymorphism, Genetic; Prostaglandin-Endoperoxide Synthases; Thrombin; Vasopressins; Virulence Factors, Bordetella | 2000 |
Combined defect in membrane expression and activation of platelet GPIIb--IIIa complex without primary sequence abnormalities in myeloproliferative disease.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aged; Antibodies, Monoclonal; Binding Sites; Blood Platelets; Calcimycin; Diglycerides; DNA, Complementary; Enzyme Activators; Flow Cytometry; Humans; Immunoblotting; Intercellular Signaling Peptides and Proteins; Ionophores; Macrophage-1 Antigen; Male; Myeloproliferative Disorders; Neutrophils; Peptides; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Polymerase Chain Reaction; Protein Binding; Protein Kinase C; Receptors, Thrombin; RNA, Messenger; Sequence Analysis, DNA; Serotonin; Signal Transduction | 2000 |
Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Cyclic AMP; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Serotonin; Signal Transduction; Thromboxane A2 | 2001 |
Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Antigens, CD; Blood Platelets; Calcimycin; Calcium; CD40 Ligand; Cells, Cultured; Clopidogrel; Collagen; Cytoplasmic Granules; Cytoskeleton; Gene Expression Regulation; Humans; Ionophores; Male; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tetraspanin 30; Thrombin; Ticlopidine | 2001 |
Differential involvement of the P2Y1 and P2YT receptors in the morphological changes of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Actins; Adenosine Diphosphate; Adenosine Diphosphate Ribose; Adenosine Monophosphate; Blood Platelets; Calcium Signaling; cdc42 GTP-Binding Protein; Cell Size; Cytoskeleton; GTP-Binding Proteins; Humans; Membrane Proteins; Microscopy, Electron; Platelet Aggregation; Platelet Aggregation Inhibitors; rac1 GTP-Binding Protein; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; rhoA GTP-Binding Protein; Thrombin | 2001 |
Voltage-dependent Ca2+ release in rat megakaryocytes requires functional IP3 receptors.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Anti-Infective Agents, Local; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Enzyme Inhibitors; Epoprostenol; Inositol 1,4,5-Trisphosphate Receptors; Male; Megakaryocytes; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Thapsigargin; Thimerosal; Vasoconstrictor Agents | 2001 |
Local anesthetic actions on thromboxane-induced platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amides; Anesthetics, Local; Bupivacaine; Humans; Lidocaine; Platelet Aggregation; Ropivacaine; Thromboxane A2 | 2001 |
Biogenesis of G-protein mediated calcium signaling in human megakaryocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Calcium Signaling; Cattle; Cell Differentiation; Cells, Cultured; Fetal Blood; Flow Cytometry; Gene Expression Regulation, Developmental; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Heterotrimeric GTP-Binding Proteins; Humans; Iloprost; Megakaryocytes; Platelet Activating Factor; Protein Isoforms; Proto-Oncogene Proteins; Stem Cells; Thrombin; Thrombopoietin | 2001 |
A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Antigens, CD; Blood Platelets; Calcium; Chromatography, Gel; Cross-Linking Reagents; Dimerization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Platelet Aggregation Inhibitors; Protein Binding; rap GTP-Binding Proteins; Receptors, IgG; Recombinant Proteins; Serotonin; Signal Transduction; Time Factors | 2002 |
Isoflurane does not further impair microvascular vasomotion in a rat model of subarachnoid hemorrhage.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Anesthetics, Inhalation; Animals; Arterioles; Capillaries; Cerebrovascular Circulation; Endothelin-1; Endothelium, Vascular; Female; Isoflurane; Male; Microscopy, Video; Nitroprusside; Parietal Lobe; Rats; Rats, Wistar; Subarachnoid Hemorrhage; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
The roles of LAT in platelet signaling induced by collagen, TxA2, or ADP.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adaptor Proteins, Signal Transducing; Adenosine Diphosphate; Animals; Antibodies; Arachidonic Acid; Blood Platelets; Carrier Proteins; Collagen; Dose-Response Relationship, Drug; Membrane Proteins; Mice; Mice, Knockout; Phosphoproteins; Platelet Aggregation; Signal Transduction; Thromboxane A2; Vasoconstrictor Agents | 2002 |
Costimulation of Gi- and G12/G13-mediated signaling pathways induces integrin alpha IIbbeta 3 activation in platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Collagen; DNA-Binding Proteins; Dose-Response Relationship, Drug; Fibrinogen; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Serine-Threonine Kinases; rho-Associated Kinases; Signal Transduction; Thrombin; Thromboxane A2 | 2002 |
Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Cells, Cultured; Dual Specificity Phosphatase 2; Egtazic Acid; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Integrin alpha1beta1; Peptide Fragments; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Receptors, Fibrinogen; Signal Transduction; Thromboxane A2 | 2002 |
Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Chelating Agents; Cyclic AMP; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Epinephrine; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinase 1; Models, Biological; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; rho-Associated Kinases; Signal Transduction; Thromboxane A2 | 2002 |
PKD: a new protein kinase C-dependent pathway in platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Blotting, Western; Crotalid Venoms; Drug Synergism; Enzyme Activation; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Humans; Immunosorbent Techniques; Lectins, C-Type; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Thrombin | 2003 |
Weak platelet agonists and U46619 induce apoptosis-like events in platelets, in the absence of phosphatidylserine exposure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Apoptosis; Blood Platelets; Collagen; Epinephrine; Gelsolin; Humans; Immunoblotting; Phosphatidylserines; Thrombin | 2002 |
Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Carrier Proteins; Collagen; Crotalid Venoms; Fibrinogen; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Peptides; Phenotype; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Tetradecanoylphorbol Acetate; Thrombin | 2003 |
Two waves of platelet secretion induced by thromboxane A2 receptor and a critical role for phosphoinositide 3-kinases.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Humans; Integrins; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphorylation; Platelet Aggregation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Thromboxane; Vasoconstrictor Agents | 2003 |
Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Alcohol Drinking; Blood Platelets; Central Nervous System Depressants; Cholesterol; Collagen; Dose-Response Relationship, Drug; Ethanol; Female; Fibrinogen; Humans; Lipoproteins, HDL; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane B2; Triglycerides; Wine | 2003 |
TRA-418, a novel compound having both thromboxane A(2) receptor antagonistic and prostaglandin I(2) receptor agonistic activities: its antiplatelet effects in human and animal platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cats; Cell Membrane; Cyclic AMP; Dogs; Epoprostenol; Fatty Acids, Unsaturated; Haplorhini; Heart Rate; Humans; Hydrazines; Inhibitory Concentration 50; Kinetics; Models, Chemical; Oxazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Rats; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Vasoconstrictor Agents | 2003 |
Costimulation of the Gi-coupled ADP receptor and the Gq-coupled TXA2 receptor is required for ERK2 activation in collagen-induced platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Cattle; Collagen; Enzyme Activation; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Integrin alpha2beta1; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Kinase C; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Thromboxane A2 | 2004 |
Platelet 12-lipoxygenase activation via glycoprotein VI: involvement of multiple signaling pathways in agonist control of H(P)ETE synthesis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Amino Acid Motifs; Arachidonate 12-Lipoxygenase; Arachidonic Acid; Blood Platelets; Calcimycin; Calcium Signaling; Carrier Proteins; Collagen; Cyclooxygenase 1; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Inflammation; Isoenzymes; Leukotrienes; Membrane Proteins; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphorylation; Platelet Activation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Quinolines; Receptors, IgG; Thrombin | 2004 |
ADP secretion and subsequent P2Y12 receptor signalling play a crucial role in thrombin-induced ERK2 activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Enzyme Activation; Epinephrine; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; In Vitro Techniques; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thrombin; Thromboxane A2 | 2004 |
Characterization of purine receptors in mouse thoracic aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aorta, Thoracic; Biological Factors; Calcimycin; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Phenylephrine; Receptors, Purinergic P2; Uridine Triphosphate | 2004 |
A platelet secretion pathway mediated by cGMP-dependent protein kinase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Collagen; Cyclic AMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Exocytosis; Female; Humans; Male; Mice; Mice, Knockout; P-Selectin; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIb-IX Complex; Receptors, Thromboxane A2, Prostaglandin H2; Signal Transduction; Temperature | 2004 |
Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin {alpha}(IIb){beta}(3) activation and platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Androstadienes; Antibodies, Monoclonal; Blood Platelets; Blood Proteins; Calcium; Chromones; Cyclooxygenase Inhibitors; Cytosol; Enzyme Activation; Enzyme Inhibitors; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoproteins; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Binding; Proto-Oncogene Proteins; rap GTP-Binding Proteins; Receptors, Cytokine; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Thrombopoietin; Thrombopoietin; Thromboxane A2; Thromboxanes; Time Factors; Type C Phospholipases; Wortmannin | 2005 |
Molecular indices of apoptosis after intermittent blood and crystalloid cardioplegia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Biomarkers; Blood; Cardioplegic Solutions; Caspase 3; Caspases; Cold Temperature; Endothelium, Vascular; Enzyme Activation; Heart; Heart Arrest, Induced; In Situ Nick-End Labeling; Microcirculation; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Donors; Nitroprusside; Phosphorylation; Potassium Compounds; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Rabbits; Random Allocation; Temperature; Vasoconstrictor Agents; Vasodilator Agents; Ventricular Function, Left | 2005 |
Platelet ADP response deteriorates in synthetic storage media.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Blood Preservation; Collagen; Cryopreservation; Humans; Organ Preservation Solutions; P-Selectin; Peptide Fragments; Plasma; Platelet Adhesiveness; Platelet Aggregation; Stress, Mechanical; Vasoconstrictor Agents | 2006 |
Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Antibodies, Monoclonal; Blood Platelets; Dose-Response Relationship, Drug; Humans; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Purinergic P2 Receptor Antagonists; rap GTP-Binding Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thrombin | 2006 |
High-dose atorvastatin improves hypercholesterolemic coronary endothelial dysfunction without improving the angiogenic response.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Angiostatins; Animals; Apoptosis; Apoptosis Inducing Factor; Arterioles; Atorvastatin; Caspase 3; Caspases; Cholesterol; Coronary Circulation; Coronary Vessels; Drug Evaluation, Preclinical; Endostatins; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Gene Expression Regulation; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Matrix Metalloproteinase 9; Myocardial Ischemia; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Receptor, TIE-2; Swine; Swine, Miniature; Vascular Endothelial Growth Factor A; Vasodilation | 2006 |
Do heterotrimeric G proteins redistribute upon G protein-coupled receptor stimulation in platelets?
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Calcium; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein Regulators; GTP-Binding Proteins; Humans; Mice; Mice, Knockout; Peptide Fragments; Receptors, Opioid; Receptors, Proteinase-Activated; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Vasoconstrictor Agents | 2006 |
Antiplatelet and antithrombotic activities of Korean Red Ginseng.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Administration, Oral; Animals; Arachidonic Acid; Blood Coagulation Tests; Carboxymethylcellulose Sodium; Carotid Artery Injuries; Carotid Artery Thrombosis; Collagen; Dose-Response Relationship, Drug; Fibrinolytic Agents; Ginsenosides; Korea; Male; Panax; Partial Thromboplastin Time; Platelet Aggregation; Platelet Aggregation Inhibitors; Prothrombin Time; Rabbits; Rats; Rats, Sprague-Dawley | 2006 |
Alteration of release and role of adenosine diphosphate and thromboxane A2 during collagen-induced aggregation of platelets from cattle with Chediak-Higashi syndrome.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cattle; Cells, Cultured; Chediak-Higashi Syndrome; Collagen; Dose-Response Relationship, Drug; Drug Synergism; Platelet Aggregation; Thromboxane A2 | 2007 |
Enhanced platelet aggregation and activation under conditions of hypothermia.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Monophosphate; Anticoagulants; Antigens, CD; Aspirin; Blood Platelets; Blood Specimen Collection; Citrates; Cold Temperature; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Hirudins; Humans; Hypothermia, Induced; In Vitro Techniques; P-Selectin; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Platelet Function Tests; Platelet Membrane Glycoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Receptors, Thrombin; Tetraspanin 30; Time Factors | 2007 |
Reciprocal regulation of platelet responses to P2Y and thromboxane receptor activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Calcium; Cyclic AMP; Cytosol; Humans; Platelet Activation; Platelet Aggregation; Protein Kinase C; Receptors, Purinergic P2; Receptors, Thromboxane; Serotonin; Signal Transduction; Thromboxanes | 2008 |
An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Arachidonic Acid; Blood Platelets; Cell Size; Collagen; Data Interpretation, Statistical; Epinephrine; Feasibility Studies; Humans; Light; Platelet Aggregation; Platelet Count; Platelet Function Tests; Prospective Studies; Reference Values; Ristocetin; Statistics, Nonparametric; Thrombocytopenia | 2008 |
Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Collagen; Flavonoids; Fruit; Glycosides; In Vitro Techniques; Magnetic Resonance Spectroscopy; Plant Leaves; Plant Stems; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Sophora; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thromboxane A2 | 2008 |
Rac1 is essential for phospholipase C-gamma2 activation in platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Lectins, C-Type; Mice; Mice, Knockout; Phospholipase C gamma; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoproteins; Poly I-C; rac1 GTP-Binding Protein; Thrombosis | 2009 |
The Gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Blood Proteins; Diacylglycerol Kinase; Diglycerides; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Phosphoproteins; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thromboxane A2 | 2008 |
Augmentation of U46619 induced human platelet aggregation by aspirin.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Adult; Aspirin; Blood Platelets; Cyclic AMP; Cyclooxygenase Inhibitors; Female; Humans; Male; Nitric Oxide Synthase; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Vasoconstrictor Agents; Young Adult | 2009 |
Normal filopodia extension in VASP-deficient platelets upon activation by adhesive matrices or soluble agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cell Adhesion Molecules; Cells, Cultured; Extracellular Matrix; Fibrinogen; Hemostasis; Mice; Mice, Knockout; Microfilament Proteins; Phosphoproteins; Platelet Activation; Pseudopodia; Thromboxane A2; von Willebrand Factor | 2009 |
Comparison of the relative activities of inducing platelet apoptosis stimulated by various platelet-activating agents.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Apoptosis; Arachidonic Acid; Blood Platelets; Calcimycin; Caspases; Collagen; Enzyme Activation; Humans; Ionophores; Membrane Potential, Mitochondrial; Phosphatidylserines; Platelet Activation; Platelet Aggregation; Thrombin; Vasoconstrictor Agents | 2009 |
Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Fibrinolytic Agents; Ionophores; Kinetics; Male; Megakaryocytes; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Potassium; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Purinergic; Receptors, Thromboxane; Signal Transduction; Thionucleotides | 2010 |
Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Binding Sites; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cyclic AMP; Fatty Acids, Unsaturated; Glyburide; Humans; Hydrazines; Platelet Aggregation Inhibitors; Receptors, Thromboxane A2, Prostaglandin H2; Scintillation Counting; Spectrometry, Fluorescence | 2010 |
The EP3-agonist sulprostone, but not prostaglandin E2 potentiates platelet aggregation in human blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Cells, Cultured; Citrates; Collagen; Dinoprostone; Drug Synergism; Hirudins; Humans; Inflammation; Platelet Aggregation; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Vasoconstrictor Agents | 2010 |
Development of a high-throughput ELISA assay for platelet function testing using platelet-rich plasma or whole blood.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Alprostadil; Antibodies, Monoclonal; Arachidonic Acid; Blood Platelets; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycoproteins; High-Throughput Screening Assays; Humans; Immunoglobulins; Integrin alpha2; Integrin beta3; Observer Variation; P-Selectin; Peptides; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Reproducibility of Results; S-Nitroso-N-Acetylpenicillamine | 2010 |
Pairwise agonist scanning predicts cellular signaling responses to combinatorial stimuli.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Crotalid Venoms; Dinoprostone; Dose-Response Relationship, Drug; Humans; Lectins, C-Type; Neural Networks, Computer; Oligopeptides; Peptide Fragments; Signal Transduction | 2010 |
Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Basidiomycota; Biological Products; Blood Platelets; Collagen; Crotalid Venoms; Epinephrine; Humans; Indoles; Lectins, C-Type; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Signal Transduction; Thrombin; Thrombosis | 2010 |
Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylation; Adenosine Diphosphate; Animals; Chromatography, High Pressure Liquid; Collagen; Ginsenosides; In Vitro Techniques; Male; Panax; Plant Extracts; Plant Roots; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Vasoconstrictor Agents | 2010 |
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Aspirin; Collagen; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Peptide Fragments; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Thromboxane A2 | 2011 |
Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Aortic Valve; Blood Vessels; Cells, Cultured; Collagen; Coronary Vessels; Dose-Response Relationship, Drug; Heart Valves; Humans; In Vitro Techniques; Inhibitory Concentration 50; Ketanserin; Kinetics; Lisuride; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitral Valve; Phosphorylation; Platelet Aggregation; Pulmonary Artery; Serotonin; Serotonin 5-HT2 Receptor Antagonists; Sus scrofa; Vasoconstriction; Vasodilation | 2012 |
Characterization of the in vivo antiplatelet activity of the antihypertensive agent losartan.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Antihypertensive Agents; Arachidonic Acid; Blood Coagulation; Carotid Artery Injuries; Losartan; Mice; Mice, Inbred C57BL; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Thrombin; Receptors, Thromboxane A2, Prostaglandin H2; Thrombosis | 2012 |
Multiscale prediction of patient-specific platelet function under flow.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Coagulation; Blood Platelets; Calcium; Crotalid Venoms; HEK293 Cells; Humans; Lectins, C-Type; Male; Microfluidic Analytical Techniques; Models, Biological; Platelet Activating Factor; Platelet Function Tests; Predictive Value of Tests; Receptors, Thromboxane; Reference Values; Signal Transduction; Thrombosis; Vasoconstrictor Agents | 2012 |
BF066, a novel dual target antiplatelet agent without significant bleeding.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arterioles; Chlorides; Collagen; Ferric Compounds; Fibrinogen; Hemorrhage; Humans; Immobilized Proteins; Mice; Mice, Inbred C57BL; Oligopeptides; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, Adenosine A2A; Thrombin; Thrombosis | 2012 |
Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Aged; Arterioles; Cardiopulmonary Bypass; Coronary Artery Bypass; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Disease Susceptibility; Endothelium, Vascular; Enzyme Induction; Female; Gene Expression Regulation; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Inflammation; Male; Microcirculation; Middle Aged; Muscle, Skeletal; Nitroprusside; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Substance P; Tyrosine; Vasoconstriction; Vasodilator Agents | 2012 |
PDK1 regulates platelet activation and arterial thrombosis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arteries; Blood Platelets; Clot Retraction; Mice; Mice, Inbred C57BL; Mice, Knockout; Platelet Activation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Thrombin; Thrombosis; Vasoconstrictor Agents | 2013 |
Cholesterol enrichment of rabbit platelets enhances the Ca(2+) entry pathway induced by platelet-derived secondary feedback agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Calcium; Cholesterol; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; Male; Rabbits; Thrombin; Thromboxane A2; Thromboxane B2 | 2013 |
Pairwise agonist scanning-flow cytometry (PAS-FC) measures inside-out signaling and patient-specific response to combinatorial platelet agonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Annexin A5; Blood Donors; Blood Platelets; Cluster Analysis; Crotalid Venoms; Dinoprostone; Flow Cytometry; Humans; Lectins, C-Type; Male; Oligopeptides; P-Selectin; Peptide Fragments; Phenotype; Phosphatidylserines; Precision Medicine; Signal Transduction | 2013 |
(-)-Epigallocatechin gallate selectively inhibits adenosine diphosphate‑stimulated human platelet activation: suppression of heat shock protein 27 phosphorylation via p38 mitogen‑activated protein kinase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Catechin; CD40 Ligand; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Molecular Chaperones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet-Derived Growth Factor; Ristocetin; Tea | 2014 |
DL-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2 synthesis and phosphodiesterase.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium; Collagen; Cyclic AMP; Humans; Phospholipases A2, Cytosolic; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2 | 2015 |
A Novel Direct Factor Xa Inhibitory Peptide with Anti-Platelet Aggregation Activity from Agkistrodon acutus Venom Hydrolysates.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Agkistrodon; Amino Acid Sequence; Animals; Anticoagulants; Blood Coagulation Tests; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Female; Hydrolysis; Male; Mice; Molecular Weight; Peptides; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Rats; Snake Venoms; Thrombosis | 2015 |
Leukemia-associated Rho guanine-nucleotide exchange factor is not critical for RhoA regulation, yet is important for platelet activation and thrombosis in mice.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Cell Degranulation; Chlorides; Crosses, Genetic; Ferric Compounds; Gene Knockout Techniques; Mice; Mice, Knockout; Oligopeptides; Organ Specificity; Platelet Activation; Platelet Aggregation; rho GTP-Binding Proteins; Rho Guanine Nucleotide Exchange Factors; rhoA GTP-Binding Protein; Thrombosis | 2015 |
N2 extenuates experimental ischemic stroke through platelet aggregation inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arteriovenous Shunt, Surgical; Blood Coagulation; Brain; Brain Ischemia; Edema; Enzyme-Linked Immunosorbent Assay; Epoprostenol; Female; Imidazoles; Male; Maze Learning; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Stroke; Thrombosis; Thromboxane A2; Vanillic Acid | 2015 |
Assessment of neonatal platelet adhesion, activation, and aggregation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adult; Blood Platelets; C-Reactive Protein; Cell Separation; Flow Cytometry; Glycoproteins; Hemorrhage; Humans; Immunoreceptor Tyrosine-Based Activation Motif; Infant, Newborn; Lectins, C-Type; Oligopeptides; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Function Tests; Platelet Glycoprotein GPIb-IX Complex; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, G-Protein-Coupled; Signal Transduction | 2016 |
Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Coagulation Disorders; Blood Platelets; Calcium Signaling; Collagen; Crotalid Venoms; Fibrin; Humans; In Vitro Techniques; Lectins, C-Type; Oligopeptides; Platelet Activation; Platelet Membrane Glycoproteins; Signal Transduction; Solubility; Thrombin | 2017 |
Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heterocyclic; Fatty Acids, Unsaturated; Female; Glucosides; Glycogen Synthase Kinase 3 beta; Hydrazines; Luteolin; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Receptors, Purinergic P2Y12; Receptors, Thromboxane A2, Prostaglandin H2; rhoA GTP-Binding Protein; Serotonin; Signal Transduction; Thromboxane A2; Tritium | 2018 |
Platelet Function Changes during Neonatal Cardiopulmonary Bypass Surgery: Mechanistic Basis and Lack of Correlation with Excessive Bleeding.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Blood Platelets; Cardiopulmonary Bypass; Cells, Cultured; Extracorporeal Circulation; Female; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Platelet Activation; Platelet Count; Platelet Function Tests; Platelet Transfusion; Postoperative Hemorrhage | 2020 |
Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Female; G-Protein-Coupled Receptor Kinases; Gene Expression Regulation; Hemostatics; Male; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Activation; Platelet Aggregation; Receptors, G-Protein-Coupled; Thionucleotides; Thrombin; Thromboxane A2 | 2020 |
Rutin present in Alibertia edulis extract acts on human platelet aggregation through inhibition of cyclooxygenase/thromboxane.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Calcium; Collagen; Cyclooxygenase Inhibitors; Gene Expression Regulation; Humans; Plant Extracts; Plant Leaves; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rubiaceae; Thromboxanes; Zebrafish | 2021 |
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; B7-H1 Antigen; Biomarkers, Tumor; Blood Platelets; Fibrinogen; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Platelet Adhesiveness; Prognosis; Programmed Cell Death 1 Receptor; Thrombin | 2022 |