adenosine has been researched along with sinefungin in 172 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (21.51) | 18.7374 |
| 1990's | 53 (30.81) | 18.2507 |
| 2000's | 36 (20.93) | 29.6817 |
| 2010's | 40 (23.26) | 24.3611 |
| 2020's | 6 (3.49) | 2.80 |
| Authors | Studies |
|---|---|
| Cooper, R; Das, P; Federbush, C; Mierzwa, R; Patel, M; Pramanik, B; Truumees, I | 1 |
| Kiss, A; Szilák, L; Venetianer, P | 1 |
| Agabian, N; McNally, KP | 1 |
| Szumlanski, CL; Van Loon, JA; Weinshilboum, RM | 1 |
| Barbes, C; Hardisson, C; Martin, CG; Sanchez, J; Yebra, MJ | 1 |
| Barton, DH; Géro, SD; Lawrence, F; Quiclet-Sire, B; Robert-Gero, M; Samadi, M | 1 |
| Borot, C; Lawrence, F; Moulay, L; Phelouzat, MA; Robert-Gero, M; Schaeverbeke, J; Schaeverbeke, M | 1 |
| Kim, BR; Yang, KH | 1 |
| Borders, DB; Carter, GT; Greenstein, M; Maiese, WM; Nietsche, JA; Pearce, CJ | 1 |
| Blanchard, P; Dodic, N; Fourrey, JL; Lawrence, F; Mouna, AM; Robert-Gero, M | 1 |
| Fujioka, M; Konishi, K | 1 |
| Cañada, FJ; Pérez-Sala, D; Rando, RR; Tan, EW | 1 |
| Bacchi, CJ; Quamina, A; Yarlett, N | 1 |
| Ellis, WY; Jackson, JE; Lawyer, PG; Limmer, BL; Mebrahtu, YB; Panisko, DM; Reed, SG; Tally, JD; Were, JB | 1 |
| Barnes, CA; Johnston, GC; Singer, RA | 1 |
| Bergerat, A; Guschlbauer, W | 1 |
| Barbés, C; Hardisson, C; Robert-Geró, M; Sánchez, J; Yebra, MJ | 1 |
| Abu-Elheiga, L; Bachrach, U; Golenser, J; Lederer, E; Messika, E; Robert-Gero, M | 1 |
| Aswad, DW; Najbauer, J | 1 |
| Avila, JL; Convit, J; Monzón, H; Rojas, T | 1 |
| Friedman, S; Som, S | 1 |
| Iwobi, MV; Neal, RA; Robert-Gero, M | 1 |
| Akedo, H; Horai, T; Inoue, H; Mukai, M; Nishikawa, S; Ohigashi, H; Shinkai, K; Takeda, Y | 1 |
| Kaufmann, W; Röttcher, D; Schillinger, D; Zweygarth, E | 1 |
| Gupta, S; Kishore, P; Shukla, OP | 1 |
| Nolan, LL | 1 |
| Ferrante, A; Lederer, E; Ljungström, I | 1 |
| Barten, DM; Hogenkamp, HP; Mirkin, BL; O'Dea, RF | 1 |
| Adams, R; Drachman, DB; Kuncl, RW | 1 |
| Malina, H; Robert-Gero, M | 1 |
| Avila, A; Avila, JL | 1 |
| Malina, H; Robert-Gero, M; Tempete, C | 2 |
| Ruby, C; Schulman, MD; Streicher, S; Valentino, D | 1 |
| Germain, BJ; O'Connor, CM | 1 |
| Lawrence, F; Nolan, LL; Paolantonacci, P; Robert-Géro, M | 1 |
| Amur, SG; Cochran, JM; Pieringer, RA; Shanker, G; Ved, HS | 1 |
| Lawrence, F; Lederer, F; Paolantonacci, P; Robert-Gero, M | 1 |
| Godeau, F; Ishizaka, T; Koide, SS | 1 |
| Johnston, GC; Li, AW; Singer, RA | 1 |
| Ryder, NS | 1 |
| Coombs, GH; Sanderson, BE; Thong, KW | 1 |
| Croft, SL; Neal, RA; Nelson, DJ | 1 |
| Lawrence, F; Paolantonacci, P; Robert-Géro, M | 1 |
| Hensens, OD; Kaplan, L; Nallin, M; Ostlind, DA; Schulman, MD; Valentino, D; Zink, D | 1 |
| Ferrante, A; Huldt, G; Lederer, E; Ljungström, I | 1 |
| Allison, AC; Dube, DK; Lederer, E; Mpimbaza, G; Rovis, L | 1 |
| Meshnick, SR | 1 |
| Robert-Géro, M; Vedel, M | 1 |
| Borchardt, RT; Pugh, CS | 1 |
| Inselburg, J | 1 |
| Hansen, JA; Mirkin, BL; O'Dea, RF; O'Leary, M | 1 |
| Bachrach, U; El-On, J; Greenblatt, CL; Lederer, E; Pearlman, E; Robert-Gero, M; Schnur, LF | 1 |
| McCammon, MT; Parks, LW | 1 |
| Baum, SG; Lederer, E; Nadler, JP; Tanowitz, HB; Wittner, M | 1 |
| Mock, GA; Moffatt, JG | 1 |
| Mizuno, Y; Tampo, H; Tsuchida, K | 1 |
| Norton, SJ; Smith, DD | 1 |
| Barbés, C; Fernandez, M; Novella, IS; Sánchez, J; Soliveri, J; Yebra, MJ | 1 |
| Kikuchi, S; Nishitani, H; Okumura, K; Taguchi, H | 1 |
| Finta, C; Kiss, A; Sulima, U; Venetianer, P | 1 |
| Bacchi, CJ; Garofalo-Hannan, J; Goldberg, B; Lyte, P; Rattendi, D; Yarlett, N | 1 |
| Connolly, BA; Szczelkun, MD | 1 |
| Connolly, BA; Jones, H; Szczelkun, MD | 1 |
| Moulay, L; Robert-Gero, M | 1 |
| Basselin, M; Lawrence, F; Phelouzat, MA; Robert-Gero, M | 1 |
| Blackburn, GM; Mekhalfia, A; Parsons, ID; Persson, B; Stockley, PG | 1 |
| He, Q; Leitch, GJ | 1 |
| Lawrence, F; Mamalaki, A; Phelouzat, MA; Robert-Gero, M; Soteriadou, KP; Tzinia, AK | 1 |
| Ballet, JJ; Brasseur, P; Favennec, L; Leméteil, D; Roussel, F | 1 |
| Artymiuk, PJ; Baldwin, GS; Connolly, BA; Hornby, DP; Kelly, SM; Price, NC; Wilson, GW | 1 |
| Lawrence, F; Phelouzat, MA; Robert-Gero, M | 1 |
| Bergman, P; Lory, S; Strom, MS | 1 |
| Chance, ML; Goad, LJ; Haughan, PA | 1 |
| Avila, A; Avila, JL; Polegre, MA | 1 |
| Furumai, T; Hasegawa, T; Hatori, M; Kakinuma, S; Oki, T; Saitoh, K; Suzuki, K | 1 |
| Ballet, JJ; Brasseur, P; Lemeteil, D | 1 |
| Kowluru, A; Li, G; Metz, SA | 1 |
| Brasseur, P; Favennec, L; Marchand, J; Tharasse-Bloch, C | 1 |
| Brown, S; Gendron, MC; Moulay, L; Robert-Gero, M; Tournier, F | 1 |
| Bleimling, N; Kozak, M; Saenger, W; Schluckebier, G; Weinhold, E | 1 |
| Agnamey, P; Ballet, JJ; Brasseur, P; Egraz-Bernard, M; Favennec, L | 1 |
| Béliveau, R; Boivin, D; Lin, W | 1 |
| Janulaitis, A; Maneliene, Z; Petrusyte, M; Vitkute, J | 1 |
| Derbécourt, T; Lawrence, F; Robert-Gero, M | 1 |
| Jones, PA; Shen, JC; Zingg, JM | 1 |
| Drummond, JT; Matthews, RG; Webb, HK | 1 |
| Podhajska, AJ; Tucholski, J; Zmijewski, JW | 1 |
| Abad-Zapatero, C; Kavanaugh, TJ; Schluckebier, G; Stewart, KD; Zhong, P | 1 |
| Ballet, JJ; Brasseur, P; Delaunay, A; Favennec, L; Gargala, G | 1 |
| Gumport, RI; Reich, NO; Szegedi, SS | 1 |
| Gumport, RI; Szegedi, SS | 1 |
| Janulaitis, A; Jurenaite-Urbanaviciene, S; Kazlauskiene, R; Lubys, A; Maneliene, Z; Petrusyte, M; Urbelyte, V | 1 |
| Ashida, A; Inagaki, K; Kataoka, A; Shu, LY; Tamura, T; Tanaka, H | 1 |
| Bugl, H; Hager, J; Jakob, U; Staker, BL | 1 |
| Iwata-Reuyl, D; Van Lanen, SG | 1 |
| Churchill, ME; Gumport, RI; Scavetta, RD; Thomas, CB | 1 |
| Agnamey, P; Ballet, JJ; Brasseur, P; Favennec, L; Leméteil, D; Li, X; Rossignol, JF | 1 |
| Gastaldo, L; Marinelli, F | 1 |
| Bujacz, G; Grazulis, S; Janowski, R; Janulaitis, A; Jaskolski, M; Tamulaitiene, G | 1 |
| Bedford, MT; Cheng, D; Lee, J | 1 |
| Hodsdon, ME; Keeler, C; Scheuermann, TH | 1 |
| Erola, A; Jansson, A; Koskiniemi, H; Mäntsälä, P; Niemi, J; Schneider, G; Wang, J | 1 |
| Fabrega, C; Hausmann, S; Lima, CD; Schneller, SW; Shuman, S; Zheng, S | 1 |
| Gabruzsk, J; Holmes, WM; Watts, JM | 1 |
| Cheng, X; Hattman, S; Horton, JR; Jeltsch, A; Liebert, K | 1 |
| Chrebet, GL; Deng, Q; Kurtz, MB; Marcy, A; Parent, SA; Perkins, AL; Wisniewski, D | 1 |
| Raghavendra, NK; Rao, DN | 1 |
| Balaña-Fouce, R; Ordóñez, D; Pérez-Pertejo, Y; Reguera, RM | 1 |
| Cappanelli, M; Jezowska-Bojczuk, M; Kaczmarek, P; Mucha, A; Skała, J; Szczepanik, W | 1 |
| Ding, M; Toth, LA | 1 |
| Gage, JL; Jiang, MX; Jin, B; Miller, MJ; Priour, A; Savela, G | 1 |
| Ghosh, A; Hausmann, S; Lima, CD; Liu, Q; Schwer, B; Shuman, S; Zheng, S | 1 |
| Chorba, JS; Li, J; Whelan, SP | 1 |
| Couture, JF; Dietzel, K; Dirk, LM; Flynn, EM; Houtz, RL; Trievel, RC | 1 |
| Cappannelli, M; Gaggelli, E; Jezowska-Bojczuk, M; Molteni, E; Mucha, A; Porciatti, E; Valensin, D; Valensin, G | 1 |
| Schwer, B; Shuman, S; Zheng, S | 1 |
| Drujon, T; Guianvarc'h, D; Ploux, O; Rey, C; Wang, Q | 1 |
| Lescar, J; Lim, SP; Vasudevan, SG; Wen, D; Yan, CK; Yap, TL | 1 |
| Bollati, M; Bolognesi, M; Canard, B; Coutard, B; de Lamballerie, X; Decroly, E; Mastrangelo, E; Milani, M; Nonnis, S; Ricagno, S; Selisko, B; Tedeschi, G | 1 |
| Benarroch, D; Qiu, ZR; Schwer, B; Shuman, S | 1 |
| Krüger, DH; Matsumura, H; Möncke-Buchner, E; Reich, S; Reuter, M; Rothenberg, M; Terauchi, R; Wagenführ, K | 1 |
| Cui, Q; Cygler, M; Lamb, SS; Matte, A; Proteau, A; Shi, R; Sulea, T; Wright, GD; Zakeri, B | 1 |
| Bardou, F; Boissier, F; Constant, P; Daffé, M; Julien, S; Mourey, L; Ploux, O; Quémard, A; Vaubourgeix, J | 1 |
| Arnaud, P; Bon, P; Déchelotte, P; Kalimouttou, S; Lahiani-Skiba, M; Skiba, M | 1 |
| Abe, M; Cortez, CC; Jones, PA; Kelly, TK; Liang, G; Marquez, VE; Miranda, TB; Yoo, CB | 1 |
| Batey, RT; Ceres, P; Garst, AD; Mondragón, E; Montange, RK; van Tyne, D | 1 |
| Fukuda, K; Inagaki, K; Ito, H; Ochi, K; Tamura, T; Yamamoto, S | 1 |
| Chao, AT; Chung, KY; Dong, H; Lescar, J; Lim, SP; Shi, PY | 1 |
| Ahmed Ouameur, A; Dridi, L; Ouellette, M | 1 |
| Dey, S; Lane, JM; Lee, RE; Rubin, EJ; Sacchettini, JC | 1 |
| Bessho, Y; Goto-Ito, S; Grosjean, H; Hikida, Y; Hirano, M; Ito, T; Itoh, Y; Kuratani, M; Nishimoto, M; Sekine, S; Yokoyama, S | 1 |
| Dong, H; Li, H; Li, Z; Lim, SP; Liu, L; Shi, PY; Zhao, Y; Zou, G | 1 |
| Brunzelle, J; Doko, E; Sirinupong, N; Yang, Z | 1 |
| Beis, K; Cameron, AD; Choudhury, HG; Iwata, S | 1 |
| Bouvet, M; Bricogne, G; Canard, B; Coutard, B; Debarnot, C; Decroly, E; Ferron, F; Gluais, L; Imbert, I; Lescar, J; Ortiz-Lombardia, M; Papageorgiou, N; Sharff, A | 1 |
| Clarkson, AB; Merali, S; Moncada, C; Perez-Leal, O | 1 |
| Arnold, L; Brown, M; Crew, A; Das, C; Emtage, S; Foreman, KW; Harriss, J; Park, F; Shaaban, S; Tucker, P; Zhu, L | 1 |
| Jeżewska-Frąckowiak, J; Skowron, PM; Zołnierkiewicz, O; Zylicz-Stachula, A | 1 |
| Alpert, TD; Jez, JM; Kim, Y; Lee, SG; Nagata, A | 1 |
| Atadja, P; Fan, H; Frederiksen, M; Gao, J; Gu, XJ; Guo, W; Harrington, E; Jiang, L; Li, E; Li, S; Lin, Y; Lu, C; Meier, P; Scheufler, C; Wang, Z; Xu, YC; Zhao, K; Zhou, S | 1 |
| Cronan, JE; Lin, S | 1 |
| Allali-Hassani, A; Amaya, MF; Blum, G; Brown, PJ; Dong, A; Hajian, T; Ibáñez, G; Li, F; Luo, M; Min, J; Schapira, M; Siarheyeva, A; Vedadi, M; Wu, H; Yu, W; Zeng, H; Zheng, W | 1 |
| Jasiecki, J; Skowron, PM; Zolnierkiewicz, O; Zylicz-Stachula, A | 1 |
| Banavali, N; Brecher, M; Chen, H; Ghosh, AK; Jones, SA; Kramer, LD; Li, H; Li, Z; Nag, D; Zhang, J; Zhou, B | 1 |
| Conn, GL; Desai, PM; Dunham, CM; Dunkle, JA; Savic, M; Vinal, K; West, DM; Zelinskaya, N | 1 |
| Chae, SW; Park, SW; Song, JJ; Yadav, MK | 1 |
| Behnke, MS; Khan, A; Sibley, LD | 1 |
| Goto-Ito, S; Hou, YM; Ito, T; Masuda, I; Sekine, S; Suh, SW; Yokoyama, S; Yoshida, K | 1 |
| Azevedo, A; Cruz, AK; Defina, T; Pedrosa, AL; Toledo, JS | 1 |
| Chen, WL; Guo, XK; Li, DD; Sun, HP; Wang, ZH; You, QD | 1 |
| Cavitt, RN; Fite, NC; Margolis, BJ; Park, KJ; Strelow, JM; Xiao, M | 1 |
| Acklam, P; Amin, N; Berdini, V; Burke, R; Chiarparin, E; Coyle, JE; Drouin, L; Harmer, JE; Heightman, TD; Hoelder, S; Hold, A; Holding, FP; Jeganathan, F; Martin, AC; Newbatt, Y; Pathuri, P; Rich, SJ; Tamanini, E; Tisi, D; Tortorici, M; van Montfort, RL; Westlake, M; Wood, A; Yon, J | 1 |
| Boura, E; Brynda, J; Hercik, K; Nencka, R | 1 |
| Beaupierre, S; Bolbach, G; Burlina, F; Dodd, RH; Drujon, T; Guianvarc'h, D; Guillou, C; Guitot, K; Pamlard, O; Sachon, E; Sagan, S | 1 |
| Beane, TJ; Koh, CS; Korostelev, AA; Madireddy, R; Zamore, PD | 1 |
| Behnke, MS; Powell, RH; Shen, B | 1 |
| Cai, X; Chen, Y; Liu, Q; Shao, L; Wang, MW; Wang, Y; Yang, D | 1 |
| Doi, S; Maeda, K; Masaki, T; Nakashima, A; Sasaki, K; Tamura, R; Ueno, T | 1 |
| Devnarain, N; Soliman, MES | 1 |
| Kaur, R; Mudgal, R; Narwal, M; Tomar, S | 1 |
| Cao, R; Fan, S; Geng, Y; Guo, H; He, Q; Huang, G; Huang, M; Li, W; Liu, M; Lv, K; Tao, Z; Wang, A; Yan, Y; Yang, J; Zhao, L; Zhong, W | 1 |
| Dumbrepatil, AB; Ghosh, S; Hoff, JD; Kennedy, RT; Malec, PA; Marsh, ENG; Zegalia, KA | 1 |
| Alcaraz, J; Baulida, J; Curto, J; Duch, P; Franco-Valls, H; García de Herreros, A; Peña, R; Sala, L; Stanisavljevic, J; Vergés, J | 1 |
| Al-Shar'i, NA; Alnabulsi, SM | 1 |
| Inagaki, K; Kuroda, Y; Maeda, K; Nemoto, M; Tamura, T; Yamagata, H | 1 |
| Boura, E; Krafcikova, P; Nencka, R; Silhan, J | 1 |
| Brunzelle, J; Inniss, NL; Kiryukhina, O; Minasov, G; Rosas-Lemus, M; Satchell, KJF; Shuvalova, L | 1 |
| Bolotokova, A; Devkota, K; Ghiabi, P; Hajian, T; Khalili Yazdi, A; Li, F; Loppnau, P; Perveen, S; Vedadi, M | 1 |
| Al-Rashood, ST; Alharbi, A; El Hassab, MA; Eldehna, WM; Eskandrani, RO; Ibrahim, TM | 1 |
| Fukuda, K; Hashimoto, K; Hasunuma, T; Hirano, T; Inagaki, K; Kanao, T; Nemoto, M; Ochi, K; Ogata, H; Ogawa, S; Sakamoto, W; Sato, F; Shimidzu, H; Tamura, T; Tsunekawa, N; Yamamoto, M; Yura, K | 1 |
| Bolotokova, A; Devkota, K; Ghiabi, P; Hajian, T; Khalili Yazdi, A; Li, F; Perveen, S; Vedadi, M | 1 |
2 review(s) available for adenosine and sinefungin
| Article | Year |
|---|---|
Recent studies on inhibitors of macromolecular synthesis and function in trypanosomes.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Allopurinol; Animals; Antimalarials; Bleomycin; Dihydroorotate Oxidase; DNA; Folic Acid Antagonists; Glutathione; Glycoproteins; Nucleosides; Ornithine Decarboxylase Inhibitors; Phenanthridines; Polyamines; Protein Biosynthesis; Pyrazoles; Quinolinium Compounds; RNA; Superoxide Dismutase; Threonine; Trypanocidal Agents; Trypanosoma | 1984 |
G9a - An Appealing Antineoplastic Target.
Topics: Adenosine; Animals; Antineoplastic Agents; Azepines; Benzimidazoles; DNA Methylation; Enzyme Inhibitors; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Molecular Targeted Therapy; Quinazolines | 2017 |
170 other study(ies) available for adenosine and sinefungin
| Article | Year |
|---|---|
Characterization of peptidyl-nucleoside antifungal antibiotics from fermentation broth.
Topics: Adenosine; Antifungal Agents; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Thin Layer; Fermentation; Hydrogen-Ion Concentration; Mass Spectrometry; Molecular Structure | 1990 |
Purification and biochemical characterization of the EcaI DNA methyltransferase.
Topics: Adenosine; Base Sequence; Binding, Competitive; Catalysis; Chemical Phenomena; Chemistry, Physical; DNA; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methylation; Molecular Sequence Data; Plasmids; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Temperature | 1992 |
Trypanosoma brucei spliced-leader RNA methylations are required for trans splicing in vivo.
Topics: Adenosine; Animals; Antiprotozoal Agents; Blotting, Northern; Kinetics; Methylation; Ribonucleoproteins; RNA Precursors; RNA Splicing; RNA, Protozoan; Trypanosoma brucei brucei | 1992 |
Human kidney thiopurine methyltransferase. Photoaffinity labeling with S-adenosyl-L-methionine.
Topics: Adenosine; Affinity Labels; Autoradiography; Chromatography, Ion Exchange; Gallic Acid; Humans; Isoenzymes; Kidney; Mercaptopurine; Methyltransferases; Photolysis; Polymorphism, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine | 1992 |
The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces.
Topics: Adenosine; Chromatography, Thin Layer; DNA; DNA Modification Methylases; Methylation; RNA, Bacterial; RNA, Ribosomal; RNA, Transfer; Streptomyces; tRNA Methyltransferases | 1991 |
Total synthesis of uracil analogues of sinefungin.
Topics: Adenosine; Animals; Antiprotozoal Agents; Kinetics; Leishmania donovani; Structure-Activity Relationship; Uracil | 1992 |
Leishmania donovani: antagonistic effect of S-adenosyl methionine on ultrastructural changes and growth inhibition induced by sinefungin.
Topics: Adenosine; Animals; Antiprotozoal Agents; Flagella; Golgi Apparatus; Hydrogen-Ion Concentration; Leishmania donovani; Methylation; Microscopy, Electron; Protein O-Methyltransferase; Protozoan Proteins; S-Adenosylmethionine | 1992 |
Effects of sinefungin and 5'-deoxy-5'-S-isobutyl-adenosine on lipopolysaccharide-induced proliferation and protein N-methylation of arginyl residues in murine splenic lymphocytes.
Topics: Adenosine; Animals; Antifungal Agents; Antimalarials; Arginine; Cell Division; Cells, Cultured; Deoxyadenosines; Female; Lipopolysaccharides; Lymphocytes; Methylation; Mice; Mice, Inbred BALB C; Protein-Arginine N-Methyltransferases; Spleen; Thionucleosides | 1991 |
The effect of methylation inhibitors on citreamicin biosynthesis in Micromonospora citrea.
Topics: Adenosine; Aminopterin; Anti-Bacterial Agents; Antifungal Agents; Chromatography, High Pressure Liquid; Methylation; Micromonospora; Oxazoles | 1991 |
Synthesis and biological activity of sinefungin analogues.
Topics: Adenosine; Animals; Antiprotozoal Agents; Kinetics; Leishmania donovani; Magnetic Resonance Spectroscopy; Thymidine | 1991 |
Reversible inactivation of recombinant rat liver guanidinoacetate methyltransferase by glutathione disulfide.
Topics: Adenosine; Animals; Cysteine; Enzyme Activation; Enzyme Reactivators; Ethylmaleimide; Glutathione; Glutathione Disulfide; Glycine; Guanidinoacetate N-Methyltransferase; Iodoacetates; Iodoacetic Acid; Kinetics; Liver; Mercaptoethanol; Methyltransferases; Oxidation-Reduction; Rats; Recombinant Proteins; S-Adenosylmethionine; Spectrum Analysis; Sulfhydryl Compounds | 1991 |
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.
Topics: Acetylcysteine; Adenosine; Animals; Cattle; Cysteine; GTP-Binding Proteins; In Vitro Techniques; Methylation; Molecular Weight; Rod Cell Outer Segment; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Transducin | 1991 |
Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Eflornithine; Histone-Lysine N-Methyltransferase; Hydrogen-Ion Concentration; Kinetics; Methylation; Protein O-Methyltransferase; Protein-Arginine N-Methyltransferases; Rats; Substrate Specificity; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Quantitative in vitro drug potency and drug susceptibility evaluation of Leishmania ssp. from patients unresponsive to pentavalent antimony therapy.
Topics: Adenosine; Animals; Antimony Sodium Gluconate; Drug Resistance; Eflornithine; Leishmania; Leishmaniasis; Meglumine; Meglumine Antimoniate; Organometallic Compounds | 1990 |
Thermotolerance is independent of induction of the full spectrum of heat shock proteins and of cell cycle blockage in the yeast Saccharomyces cerevisiae.
Topics: Adenosine; Antifungal Agents; Cell Cycle; Heat-Shock Proteins; Hydroxyurea; Kinetics; Mating Factor; Molecular Weight; Peptides; Phenanthrolines; Pheromones; Saccharomyces cerevisiae; Temperature | 1990 |
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli.
Topics: Adenosine; Allosteric Regulation; Base Sequence; Binding Sites; Binding, Competitive; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Kinetics; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Sodium Chloride; Temperature; Thermodynamics | 1990 |
Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria.
Topics: Adenosine; Chromatography, Thin Layer; DNA Modification Methylases; Protein Methyltransferases; S-Adenosylhomocysteine; Streptomyces | 1990 |
Effect of sinefungin on macromolecular biosynthesis and cell cycle of Plasmodium falciparum.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Autoradiography; DNA, Protozoan; Electrophoresis, Polyacrylamide Gel; Molecular Structure; Plasmodium falciparum; Polyamines; Protozoan Proteins; Spermidine; Spermine | 1990 |
Diversity of methyl acceptor proteins in rat pheochromocytoma (PC12) cells revealed after treatment with adenosine dialdehyde.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Deoxyadenosines; Electrophoresis, Gel, Two-Dimensional; Methylation; Molecular Weight; Neoplasm Proteins; Nerve Tissue Proteins; Pheochromocytoma; Rats; S-Adenosylmethionine; Thionucleosides; Tubercidin; Tumor Cells, Cultured | 1990 |
Sinefungin as treatment for American Leishmania in sensitive BALB/c and resistant C57BL/6 mice.
Topics: Adenosine; Animals; Antiprotozoal Agents; Cells, Cultured; Disease Models, Animal; Immunity, Innate; Leishmania; Leishmaniasis; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure | 1990 |
Direct photolabeling of the EcoRII methyltransferase with S-adenosyl-L-methionine.
Topics: Adenosine; Affinity Labels; Azides; Base Sequence; Chemical Precipitation; Dithiothreitol; DNA-Cytosine Methylases; DNA, Bacterial; Escherichia coli; Kinetics; Mercaptoethanol; Methylation; Photochemistry; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Trichloroacetic Acid; Ultraviolet Rays | 1990 |
Antileishmanial effect of free and encapsulated sinefungin against Leishmania donovani infections in BALB/c mice.
Topics: Adenosine; Animals; Antiprotozoal Agents; Capsules; Leishmania donovani; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C | 1989 |
Inhibition of in vitro tumor cell invasion by transmethylation inhibitors.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Deoxyadenosines; Fibrosarcoma; Humans; Kinetics; Liver Neoplasms, Experimental; Lung Neoplasms; Melanoma, Experimental; Methylation; Neoplasm Invasiveness; Rats; Rats, Inbred Strains; Thionucleosides; Tumor Cells, Cultured | 1989 |
Evaluation of sinefungin for the treatment of Trypanosoma (Nannomonas) congolense infections in goats.
Topics: Adenosine; Animals; Drug Administration Schedule; Drug Evaluation; Female; Goats; Kidney; Male; Trypanocidal Agents; Trypanosoma congolense; Trypanosomiasis, African; Urea | 1986 |
Polyamine metabolism as a target for growth inhibition of Acanthamoeba culbertsoni.
Topics: Acanthamoeba; Adenosine; Adenosylmethionine Decarboxylase; Aldehydes; Animals; Cyclohexylamines; Eflornithine; Polyamines; Pyruvaldehyde | 1987 |
Molecular target of the antileishmanial action of sinefungin.
Topics: Adenosine; Animals; Antimalarials; Aphidicolin; Cells, Cultured; Cricetinae; Diterpenes; DNA Polymerase II; Leishmania mexicana; Male; Mesocricetus; Mutagenicity Tests; Nucleic Acid Synthesis Inhibitors; Protein Biosynthesis | 1987 |
Antitoxoplasmosis properties of sinefungin in mice.
Topics: Adenosine; Animals; Coccidiostats; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred Strains; Toxoplasmosis, Animal | 1988 |
Effect of adenosine analogues on protein carboxylmethyltransferase, S-adenosylhomocysteine hydrolase, and ribonucleotide reductase activity in murine neuroblastoma cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cell Survival; Cells, Cultured; Hydrolases; Mice; Neuroblastoma; Protein Methyltransferases; Protein O-Methyltransferase; Ribonucleotide Reductases; S-Adenosylhomocysteine; Tubercidin | 1987 |
Inhibition of methyltransferase reduces the turnover of acetylcholine receptors.
Topics: Adenine; Adenosine; Animals; Dose-Response Relationship, Drug; Endocytosis; Homocysteine; In Vitro Techniques; Methionine; Methyltransferases; Muscles; Myasthenia Gravis; Phospholipids; Rats; Receptors, Nicotinic | 1988 |
Regulation of sinefungin biosynthesis by the wild-type strain and mutants of Streptomyces incarnatus.
Topics: Adenosine; Adenosine Triphosphate; Antifungal Agents; Arginine; Citrulline; Mutation; Ornithine; Streptomyces; Uridine | 1988 |
Correlation of sinefungin susceptibility and drug-affinity for protein carboxymethyltransferase activity in American Leishmania species.
Topics: Adenosine; Animals; Antiprotozoal Agents; Chemical Phenomena; Chemistry; Enzyme Activation; Leishmania; Leishmania braziliensis; Leishmania mexicana; Protein Methyltransferases; Protein O-Methyltransferase | 1987 |
Biosynthesis of sinefungin by cell-free extract of Streptomyces incarnatus NRRL 8089.
Topics: Adenosine; Adenosine Triphosphate; Antifungal Agents; Arginine; Cell-Free System; Chromatography, High Pressure Liquid; Saccharomyces; Streptomyces | 1987 |
"Streptomyces avermitilis" mutants defective in methylation of avermectins.
Topics: Adenosine; Anthelmintics; Bacterial Proteins; Ivermectin; Methylation; Methyltransferases; Mutation; Streptomyces | 1987 |
Kinetic and electrophoretic analysis of transmethylation reactions in intact Xenopus laevis oocytes.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Kinetics; Methionine; Methylation; Molecular Weight; Oocytes; S-Adenosylmethionine; Xenopus laevis | 1987 |
Inhibition of leishmanial DNA synthesis by sinefungin.
Topics: Adenosine; Animals; Cell Line; DNA Replication; Leishmania; Macrophages; Mice; Phosphorylation; Protein Biosynthesis; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity; Thymidine; Transcription, Genetic | 1987 |
Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Cells, Cultured; Embryo, Mammalian; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Methyltransferases; Mice; Myelin Proteins; Myelin Sheath; Protein Methyltransferases; Protein-Arginine N-Methyltransferases | 1986 |
Protein methylation and protein methylases in Leishmania donovani and Leishmania tropica promastigotes.
Topics: Adenosine; Amino Acids; Animals; Anti-Bacterial Agents; Histones; Leishmania donovani; Leishmania tropica; Methylation; Protein Methyltransferases; Proteins | 1986 |
Early stimulation of phospholipid methylation in Xenopus oocytes by progesterone.
Topics: Adenosine; Animals; Calcium; Deoxyadenosines; Female; Meiosis; Methylation; Methyltransferases; Oocytes; Phospholipids; Progesterone; Thionucleosides; Tubercidin; Xenopus laevis | 1985 |
Effects of sinefungin on rRNA production and methylation in the yeast Saccharomyces cerevisiae.
Topics: Adenosine; Cell Division; Methionine; Methylation; RNA, Ribosomal; Saccharomyces cerevisiae; Uracil | 1985 |
Effect of allylamine antimycotic agents on fungal sterol biosynthesis measured by sterol side-chain methylation.
Topics: Adenosine; Allylamine; Amines; Antifungal Agents; Candida; Candida albicans; Culture Media; Ergosterol; Hydrogen-Ion Concentration; Methionine; Methylation; Naphthalenes; Terbinafine; Trichophyton | 1985 |
S-Adenosylhomocysteine hydrolase activity in Trichomonas vaginalis and other trichomonads.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Deoxyadenosines; Edetic Acid; Eukaryota; Hydrogen-Ion Concentration; Hydrolases; Liver; Trichomonas vaginalis; Tritrichomonas; Vidarabine | 1985 |
Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026.
Topics: Adenosine; Allopurinol; Aminoquinolines; Animals; Antiprotozoal Agents; Cricetinae; Female; Formycins; Leishmania; Leishmaniasis; Leishmaniasis, Visceral; Macrophages; Mice; Mice, Inbred Strains; Ribonucleosides; Thionucleosides | 1985 |
Enhanced sinefungin production by medium improvement, mutagenesis and protoplast regeneration of Streptomyces incarnatus NRRL 8089.
Topics: Adenosine; Antifungal Agents; Antimalarials; Culture Media; Fermentation; Mutation; Protoplasts; Regeneration; Streptomyces | 1985 |
Differential effect of sinefungin and its analogs on the multiplication of three Leishmania species.
Topics: Adenosine; Animals; Cell Division; Chemical Phenomena; Chemistry; Kinetics; Leishmania; Microbial Sensitivity Tests; Protein Methyltransferases; Structure-Activity Relationship | 1985 |
Demethylavermectins. Biosynthesis, isolation and characterization.
Topics: Adenosine; Anthelmintics; Insecticides; Ivermectin; Lactones; Methyltransferases; Streptomyces | 1985 |
Amoebicidal activity of the antifungal antibiotic sinefungin against Entamoeba histolytica.
Topics: Adenosine; Amebicides; Animals; Antifungal Agents; Entamoeba histolytica; Microbial Sensitivity Tests | 1984 |
Antitrypanosomal activity of sinefungin.
Topics: Adenosine; Animals; Male; Mice; Mice, Inbred BALB C; Trypanosoma; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Comparative effect of S-adenosyl-homocysteine (SAH) and Sinefungin on tRNA-base methylation in whole cells and in vitro.
Topics: Adenine; Adenosine; Animals; Antifungal Agents; Avian Sarcoma Viruses; Cell Transformation, Viral; Escherichia coli; Guanine; Homocysteine; Methylation; RNA, Transfer; S-Adenosylhomocysteine | 1981 |
Effects of S-adenosylhomocysteine analogues on vaccinia viral messenger ribonucleic acid synthesis and methylation.
Topics: Adenosine; Chemical Phenomena; Chemistry; DNA-Directed RNA Polymerases; Homocysteine; Kinetics; Methyltransferases; Nucleotidyltransferases; RNA, Viral; S-Adenosylhomocysteine; Structure-Activity Relationship; Vaccinia virus | 1982 |
Induction and selection of drug resistant mutants of Plasmodium falciparum.
Topics: Adenosine; Animals; Aphidicolin; Cycloheximide; Diterpenes; Drug Resistance; Mutation; Plasmodium falciparum; Selection, Genetic | 1984 |
Protein carboxyl-O-methyltransferase activity in cultured C-1300 neuroblastoma cells.
Topics: Adenosine; Animals; Cells, Cultured; Kinetics; Mice; Neuroblastoma; Protein Methyltransferases; Protein O-Methyltransferase; S-Adenosylhomocysteine; Tissue Distribution | 1983 |
Inhibitory activity of sinefungin and SIBA (5'-deoxy-5'-S-isobutylthio-adenosine) on the growth of promastigotes and amastigotes of different species of Leishmania.
Topics: Adenosine; Animals; Antimalarials; Cell Division; Cells, Cultured; Deoxyadenosines; Leishmania; Leishmaniasis; Macrophages; Mice; Mice, Inbred C3H; Species Specificity; Thionucleosides | 1980 |
Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs.
Topics: Adenosine; Ergosterol; Methylation; Methyltransferases; S-Adenosylmethionine; Saccharomyces cerevisiae; Sterols; Structure-Activity Relationship | 1981 |
The effect of adenosine analogues on the in vitro growth of Trypanosoma cruzi.
Topics: Adenosine; Animals; Antimalarials; Deoxyadenosines; Dose-Response Relationship, Drug; Thionucleosides; Trypanosoma cruzi | 1982 |
An approach to the total synthesis of sinefungin.
Topics: Adenosine; Antifungal Agents; Chromatography, Thin Layer; Indicators and Reagents; Isomerism; Magnetic Resonance Spectroscopy | 1982 |
Toward the total synthesis of Sinefungin.
Topics: Adenosine; Antifungal Agents; Indicators and Reagents; Methods | 1982 |
Inhibition of cyclopropane fatty acid synthase by sinefungin and A9145C.
Topics: Adenosine; Kinetics; Lactobacillus; Methyltransferases | 1980 |
Effect of 5-azacytidine and sinefungin on Streptomyces development.
Topics: Adenosine; Anti-Bacterial Agents; Antifungal Agents; Azacitidine; Bacterial Proteins; DNA-Binding Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Sigma Factor; Spores, Bacterial; Streptomyces; Streptomyces antibioticus; Transcription Factors | 1995 |
Finding of a homarine-synthesizing enzyme in turban shell and some properties of the enzyme.
Topics: Adenosine; Alkaloids; Animals; Cations, Divalent; Enzyme Inhibitors; Glycine; Invertebrates; Methyltransferases; Picolinic Acids; S-Adenosylhomocysteine; S-Adenosylmethionine; Snails; Species Specificity | 1995 |
Purification of the KpnI DNA methyltransferase and photolabeling of the enzyme with S-adenosyl-L-methionine.
Topics: Adenosine; Cloning, Molecular; Escherichia coli; Molecular Sequence Data; Protein Binding; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Ultraviolet Rays | 1995 |
Fate of soluble methionine in African trypanosomes: effects of metabolic inhibitors.
Topics: Adenosine; Animals; Half-Life; Methionine; S-Adenosylmethionine; Trypanocidal Agents; Trypanosoma brucei brucei | 1995 |
Sequence-specific binding of DNA by the EcoRV restriction and modification enzymes with nucleic acid and cofactor analogues.
Topics: Adenosine; Base Sequence; Binding Sites; Chromatography, High Pressure Liquid; DNA; Escherichia coli; Magnesium; Methylation; Molecular Sequence Data; Oligodeoxyribonucleotides; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 1995 |
Probing the protein-DNA interface of the EcoRV modification methyltransferase bound to its recognition sequence, GATATC.
Topics: Adenosine; Base Sequence; Binding Sites; Computer Graphics; DNA; Escherichia coli; Ethylnitrosourea; Exodeoxyribonucleases; Methylation; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Phosphates; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 1995 |
Leishmania donovani: enhanced expression of soluble acid phosphatase in the presence of sinefungin, an antiparasitic agent.
Topics: Acid Phosphatase; Adenosine; Animals; Antiprotozoal Agents; Blotting, Western; Cytosol; Flagella; Golgi Apparatus; Histocytochemistry; Kinetics; Leishmania donovani; Microscopy, Electron; Molecular Weight | 1995 |
Sinefungin shares AdoMet-uptake system to enter Leishmania donovani promastigotes.
Topics: Adenosine; Animals; Drug Resistance; Kinetics; Leishmania donovani; Membrane Transport Proteins; Protozoan Proteins; S-Adenosylmethionine | 1995 |
Probing the molecular mechanism of action of co-repressor in the E. coli methionine repressor-operator complex using surface plasmon resonance (SPR).
Topics: Adenosine; Bacterial Proteins; Binding Sites; DNA, Bacterial; Electrochemistry; Escherichia coli; Escherichia coli Proteins; Hydrogen-Ion Concentration; Kinetics; Operon; Recombinant Proteins; Repetitive Sequences, Nucleic Acid; Repressor Proteins; S-Adenosylmethionine | 1995 |
Putative anticryptosporidial agents tested with an immunodeficient mouse model.
Topics: Adenosine; Animals; Antiprotozoal Agents; Coccidiostats; Cryptosporidiosis; Cryptosporidium parvum; Dehydroepiandrosterone; Immunologic Deficiency Syndromes; Lasalocid; Male; Mice; Mice, Nude; Splenectomy | 1994 |
Expression of the major surface glycoprotein of Leishmania, gp63, in wild-type and sinefungin-resistant promastigotes.
Topics: Adenosine; Animals; Antiprotozoal Agents; Drug Resistance; Endopeptidases; Leishmania; Leishmaniasis; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Protozoan Proteins; RNA, Messenger | 1994 |
An immunosuppressed rat model for evaluation of anti-Cryptosporidium activity of sinefungin.
Topics: Adenosine; Animals; Coccidiostats; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Feces; Immunocompromised Host; Lasalocid; Male; Rats; Rats, Sprague-Dawley | 1994 |
Ligand-induced conformational states of the cytosine-specific DNA methyltransferase M.HgaI-2.
Topics: Adenosine; Amino Acid Sequence; Base Sequence; Circular Dichroism; DNA; DNA-Cytosine Methylases; Ligands; Molecular Sequence Data; Protein Structure, Secondary; S-Adenosylmethionine | 1994 |
Characterization of sinefungin-resistant Leishmania donovani promastigotes.
Topics: Adenosine; Animals; Antiprotozoal Agents; Drug Resistance; Leishmania donovani; Polyamines; Protein Methyltransferases; Selection, Genetic | 1993 |
Identification of active-site cysteines in the conserved domain of PilD, the bifunctional type IV pilin leader peptidase/N-methyltransferase of Pseudomonas aeruginosa.
Topics: Adenosine; Alkylation; Amino Acid Sequence; Bacterial Outer Membrane Proteins; Bacterial Proteins; Binding Sites; Cloning, Molecular; Cysteine; Endopeptidases; Fimbriae Proteins; Methylation; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Sequence Homology, Amino Acid; Sulfhydryl Reagents | 1993 |
Effects of sinefungin on growth and sterol composition of Leishmania promastigotes.
Topics: Adenosine; Animals; Antiprotozoal Agents; Leishmania; Methylation; Sterols | 1993 |
Inhibitory effects of sinefungin and its cyclic analog on the multiplication of Trypanosoma cruzi isolates.
Topics: Adenosine; Animals; Antiprotozoal Agents; Culture Media; DNA, Protozoan; Humans; Protozoan Proteins; RNA, Protozoan; Trypanosoma cruzi | 1993 |
Biosynthesis of the pradimicin family of antibiotics. III. Biosynthetic pathway of both pradimicins and benanomicins.
Topics: Actinomycetales; Adenosine; Antibiotics, Antineoplastic; Antifungal Agents; Fermentation; Mutation | 1993 |
Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.
Topics: Adenosine; Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Dose-Response Relationship, Drug; Feces; Immunosuppression Therapy; Rats; Rats, Sprague-Dawley | 1993 |
Characterization of prenylcysteine methyltransferase in insulin-secreting cells.
Topics: Adenosine; Animals; Cell Fractionation; Cell Line; Enzyme Inhibitors; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Organelles; Protein Methyltransferases; Rats; S-Adenosylhomocysteine; Subcellular Fractions | 1996 |
Determination of sinefungin in rat plasma by high-performance liquid chromatography.
Topics: Adenosine; Animals; Antiprotozoal Agents; Chromatography, High Pressure Liquid; Injections, Intravenous; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Vidarabine | 1995 |
Sinefungin and taxol effects on cell cycle and cytoskeleton of Leishmania donovani promastigotes.
Topics: Actins; Adenosine; Animals; Antiprotozoal Agents; Cell Cycle; Cytoskeleton; DNA, Protozoan; Flow Cytometry; Fluorescent Dyes; Leishmania donovani; Microtubules; Paclitaxel; Plicamycin | 1996 |
Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to the adenine-specific DNA methyltransferase M.TaqI.
Topics: Adenosine; Binding Sites; Catalysis; Crystallography, X-Ray; Electrochemistry; Enzyme Inhibitors; Escherichia coli; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Spectrometry, Fluorescence | 1997 |
Inhibition of complete development of Cryptosporidium parvum in Caco-2 cells.
Topics: Adenosine; Amebicides; Animals; Antiprotozoal Agents; Caco-2 Cells; Cryptosporidium parvum; Humans; Paromomycin | 1996 |
Essential arginine residues in isoprenylcysteine protein carboxyl methyltransferase.
Topics: Adenosine; Animals; Arginine; Cell Membrane; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kidney; Male; Methylation; Phenylglyoxal; Protein Methyltransferases; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1997 |
BplI, a new BcgI-like restriction endonuclease, which recognizes a symmetric sequence.
Topics: Adenosine; Bacillus; Bacteriophage lambda; Binding Sites; Deoxyribonucleases, Type II Site-Specific; DNA, Viral; Magnesium; Plasmids; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity | 1997 |
Proton-ATPase activities involved in the uptake of an S-adenosylmethionine analogue.
Topics: Adenosine; Adenosine Triphosphatases; Animals; Biological Transport, Active; Enzyme Inhibitors; Hydrogen-Ion Concentration; Ionophores; Kinetics; Leishmania donovani; Proton-Motive Force; Proton-Translocating ATPases; S-Adenosylmethionine; Sodium | 1998 |
Enzyme-mediated cytosine deamination by the bacterial methyltransferase M.MspI.
Topics: Adenosine; Bacterial Proteins; Cytosine; Deamination; Deoxyadenosines; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Molecular Structure; Moraxella; Mutation; Neomycin; S-Adenosylhomocysteine; S-Adenosylmethionine | 1998 |
Cobalamin-dependent methionine synthase and serine hydroxymethyltransferase: targets for chemotherapeutic intervention?
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenosine; Drug Design; Drug Therapy; Enzyme Inhibitors; Glycine Hydroxymethyltransferase; Humans; Kinetics; Molecular Structure; Threonine; Transcobalamins | 1998 |
Two intertwined methylation activities of the MmeI restriction-modification class-IIS system from Methylophilus methylotrophus.
Topics: Adenosine; Deoxyribonucleases, Type II Site-Specific; DNA Methylation; DNA, Bacterial; Gram-Negative Aerobic Bacteria; Methylation; Methyltransferases; S-Adenosylmethionine | 1998 |
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism.
Topics: Adenosine; Amino Acid Sequence; Antifungal Agents; Bacillus subtilis; Binding Sites; Crystallography, X-Ray; Drug Resistance, Microbial; Ligands; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Secondary; RNA, Ribosomal, 23S; S-Adenosylhomocysteine; S-Adenosylmethionine | 1999 |
Enzyme immunoassay detection of Cryptosporidium parvum inhibition by sinefungin in sporozoite infected HCT-8 enterocytic cells.
Topics: Adenosine; Amebicides; Animals; Antiprotozoal Agents; Cell Line; Cryptosporidium parvum; Dose-Response Relationship, Drug; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Parasite Egg Count; Paromomycin; Pentamidine; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase.
Topics: Adenine; Adenosine; Binding Sites; Buffers; Carbon Radioisotopes; Catalysis; Chromatography, High Pressure Liquid; Coenzymes; DNA; DNA Methylation; DNA-Binding Proteins; Fluorescence; Kinetics; Nucleic Acid Conformation; Protein Binding; Rhodobacter sphaeroides; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thermodynamics | 2000 |
DNA binding properties in vivo and target recognition domain sequence alignment analyses of wild-type and mutant RsrI [N6-adenine] DNA methyltransferases.
Topics: Adenine; Adenosine; Amino Acid Sequence; Amino Acid Substitution; Bacteriophages; Binding Sites; Catalysis; DNA; DNA Methylation; DNA-Binding Proteins; Escherichia coli; Gene Expression Regulation, Bacterial; Isopropyl Thiogalactoside; Lysogeny; Molecular Sequence Data; Mutation; Phylogeny; Plasmids; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thermodynamics | 2000 |
Characterization of BseMII, a new type IV restriction-modification system, which recognizes the pentanucleotide sequence 5'-CTCAG(N)(10/8)/.
Topics: Adenosine; Base Sequence; Binding Sites; Cloning, Molecular; Conserved Sequence; DNA Restriction Enzymes; Geobacillus stearothermophilus; Magnesium; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Protein Subunits; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Analysis, DNA; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity | 2001 |
An in vitro screening method for DNA cytosine-C5-methylase inhibitor.
Topics: Adenosine; Bacteria; Deoxyribonucleases, Type II Site-Specific; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Restriction-Modification Enzymes; DNA-Cytosine Methylases; Electrophoresis, Agar Gel; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; S-Adenosylmethionine; Sequence Homology, Nucleic Acid; X Chromosome | 2002 |
Active site in RrmJ, a heat shock-induced methyltransferase.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Cell Cycle Proteins; Heat-Shock Proteins; Methyltransferases; Molecular Sequence Data; Polyribosomes; RNA, Ribosomal, 23S; Structure-Activity Relationship | 2002 |
Kinetic mechanism of the tRNA-modifying enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA).
Topics: Adenosine; Binding, Competitive; Catalysis; Escherichia coli; Isomerases; Kinetics; Magnetic Resonance Spectroscopy; Nucleoside Q; Pentosyltransferases; Ribose; RNA, Transfer; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding.
Topics: Adenosine; Amino Acid Motifs; Binding Sites; Catalytic Domain; Chlorine; Crystallography, X-Ray; Ligands; Models, Chemical; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2003 |
Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.
Topics: Adenosine; Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Feces; Immunocompromised Host; Male; Nitro Compounds; Parasite Egg Count; Paromomycin; Rats; Rats, Sprague-Dawley; Thiazoles | 2003 |
Changes in GE2270 antibiotic production in Planobispora rosea through modulation of methylation metabolism.
Topics: Actinomycetales; Adenosine; Anti-Bacterial Agents; Culture Media; Drug Interactions; Fermentation; Methionine; Methylation; Molecular Structure; Peptides; Peptides, Cyclic; Thiazoles; Vitamin B 12 | 2003 |
Crystallization and preliminary crystallographic studies of a bifunctional restriction endonuclease Eco57I.
Topics: Adenosine; Crystallization; Crystallography, X-Ray; DNA; DNA Restriction Enzymes; Escherichia coli; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2004 |
Techniques in protein methylation.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; DNA-Binding Proteins; Enzyme Inhibitors; Glutathione Transferase; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Poly(A)-Binding Protein I; Precipitin Tests; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; RNA-Binding Proteins; S-Adenosylmethionine; Signal Transduction; Substrate Specificity | 2004 |
Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone.
Topics: Adenosine; Animals; Conserved Sequence; Mammals; Methyltransferases; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Pseudomonas syringae; S-Adenosylmethionine | 2004 |
Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor.
Topics: Adenosine; Anthracyclines; Antimalarials; Chromatography, High Pressure Liquid; Chromatography, Liquid; Coenzymes; Hydroxylation; Mass Spectrometry; Mixed Function Oxygenases; Mutagenesis; Oxygen; Protein Structure, Tertiary; S-Adenosylmethionine; Streptomyces; Substrate Specificity | 2005 |
Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis.
Topics: Adenosine; Animals; Binding Sites; Crystallization; Encephalitozoon cuniculi; Enzyme Inhibitors; Guanosine Triphosphate; Hydrogen-Ion Concentration; Methylation; Methyltransferases; Models, Molecular; Molecular Structure; Mutagenesis; Mutation, Missense; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Substrate Specificity | 2005 |
Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase.
Topics: Adenosine; Amino Acid Sequence; Anticodon; Base Sequence; Escherichia coli Proteins; Fluorescence Resonance Energy Transfer; Ligands; Methylation; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Protein Conformation; Protein Footprinting; RNA-Binding Proteins; RNA, Transfer, Leu; S-Adenosylmethionine; Sequence Alignment; Thermotoga maritima; tRNA Methyltransferases | 2005 |
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.
Topics: Adenine; Adenosine; Amino Acid Sequence; Amino Acid Substitution; Bacteriophage T4; Base Sequence; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; DNA; Escherichia coli; Escherichia coli Proteins; Kinetics; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides; Protein Binding; Protein Conformation; S-Adenosylhomocysteine; Sequence Homology, Amino Acid; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Viral Proteins | 2005 |
Cell-based assays to detect inhibitors of fungal mRNA capping enzymes and characterization of sinefungin as a cap methyltransferase inhibitor.
Topics: Adenosine; Amino Acid Sequence; Enzyme Inhibitors; Genes, Reporter; Molecular Sequence Data; Nucleotidyltransferases; Plasmids; Saccharomyces cerevisiae; Sequence Homology, Amino Acid | 2005 |
Exogenous AdoMet and its analogue sinefungin differentially influence DNA cleavage by R.EcoP15I--usefulness in SAGE.
Topics: Adenosine; Deoxyribonucleases, Type III Site-Specific; DNA; DNA, Circular; DNA, Superhelical; Gene Expression Profiling; Repressor Proteins; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2005 |
Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani.
Topics: Adenosine; Animals; Cloning, Molecular; Drug Resistance; Leishmania donovani; Methionine Adenosyltransferase; Neomycin; Polyamines; S-Adenosylmethionine; Trypanosomatina | 2006 |
Influence of the physiologically widespread substances on the oxidative activity of copper(II) complexes with sinefungin, a nucleoside antibiotic.
Topics: Adenosine; Anti-Bacterial Agents; Copper; DNA; DNA Damage; Hydrogen-Ion Concentration; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Reactive Oxygen Species | 2006 |
mRNA expression in mouse hypothalamus and basal forebrain during influenza infection: a novel model for sleep regulation.
Topics: Acute-Phase Proteins; Adenosine; Animals; Disease Models, Animal; Hypothalamus; Intramolecular Oxidoreductases; Lipocalin-2; Lipocalins; Male; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Oncogene Proteins; Orthomyxoviridae Infections; Prosencephalon; Receptors, Corticotropin-Releasing Hormone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sleep | 2006 |
Substrate-dependent dihydroxylation of substituted cyclopentenes: toward the syntheses of carbocyclic sinefungin and noraristeromycin.
Topics: Adenosine; Cyclopentanes; Molecular Structure; Ornithine | 2006 |
Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity.
Topics: Adenosine; Antifungal Agents; Binding Sites; Crystallography, X-Ray; DNA Mutational Analysis; Encephalitozoon cuniculi; Guanine; Kinetics; Methylation; Methyltransferases; Models, Molecular; Mutation; Protein Binding; Saccharomyces cerevisiae | 2006 |
Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation.
Topics: Adenosine; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Cricetinae; Drug Resistance, Viral; Enzyme Inhibitors; Methylation; Mutation; Promoter Regions, Genetic; RNA Caps; RNA-Dependent RNA Polymerase; RNA, Viral; Streptomyces; Vesicular stomatitis Indiana virus; Viral Matrix Proteins; Viral Plaque Assay; Viral Proteins; Virus Replication | 2007 |
Kinetic manifestation of processivity during multiple methylations catalyzed by SET domain protein methyltransferases.
Topics: Adenosine; Animals; Catalysis; Cattle; Cell Cycle Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Kinetics; Lysine; Methylation; Methyltransferases; Models, Chemical; Multienzyme Complexes; Pisum sativum; Plant Proteins; Protein Methyltransferases; Protein Structure, Tertiary; S-Adenosylhomocysteine; Schizosaccharomyces pombe Proteins | 2007 |
1H and 13C NMR study of the complex formed by copper(II) with the nucleoside antibiotic sinefungin.
Topics: Adenosine; Antifungal Agents; Copper; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure | 2007 |
Sinefungin resistance of Saccharomyces cerevisiae arising from Sam3 mutations that inactivate the AdoMet transporter or from increased expression of AdoMet synthase plus mRNA cap guanine-N7 methyltransferase.
Topics: Adenosine; Amino Acid Transport Systems; Antifungal Agents; Drug Resistance, Fungal; Methionine Adenosyltransferase; Methyltransferases; Mutation; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies.
Topics: Adenosine; Anti-Bacterial Agents; Catalysis; Drug Evaluation, Preclinical; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fatty Acids; Methyltransferases; Models, Biological; Small Molecule Libraries | 2008 |
A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.
Topics: Adenosine; Binding Sites; Biochemistry; Dengue Virus; Enzyme Inhibitors; Guanosine Triphosphate; Kinetics; Methylation; Methyltransferases; S-Adenosylhomocysteine; Scintillation Counting; Sensitivity and Specificity; Viral Proteins | 2008 |
Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Biological Assay; Crystallography, X-Ray; Flavivirus; Guanosine Triphosphate; Methyltransferases; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; RNA Caps; S-Adenosylmethionine; Sequence Alignment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Viral Nonstructural Proteins | 2009 |
Characterization of a mimivirus RNA cap guanine-N2 methyltransferase.
Topics: Adenosine; Amino Acid Sequence; Animals; DNA Viruses; Enzyme Inhibitors; Guanosine; Humans; Methyltransferases; Molecular Sequence Data; RNA Caps; RNA, Messenger; S-Adenosylhomocysteine; Sequence Alignment | 2009 |
Functional characterization and modulation of the DNA cleavage efficiency of type III restriction endonuclease EcoP15I in its interaction with two sites in the DNA target.
Topics: Adenosine; Base Sequence; Binding Sites; Deoxyribonucleases, Type III Site-Specific; DNA Methylation; DNA, Bacterial; Escherichia coli; Gene Expression Profiling; S-Adenosylmethionine; Substrate Specificity | 2009 |
Structure and function of the glycopeptide N-methyltransferase MtfA, a tool for the biosynthesis of modified glycopeptide antibiotics.
Topics: Actinomycetales; Adenosine; Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Methyltransferases; Models, Molecular; Point Mutation; Protein Binding; Protein Multimerization; S-Adenosylhomocysteine; S-Adenosylmethionine; Teicoplanin | 2009 |
S-adenosyl-N-decyl-aminoethyl, a potent bisubstrate inhibitor of mycobacterium tuberculosis mycolic acid methyltransferases.
Topics: Adenosine; Catalytic Domain; Cell Division; Crystallography, X-Ray; Enzyme Inhibitors; Methyltransferases; Models, Molecular; Molecular Structure; Mycobacterium; Mycobacterium tuberculosis; Mycolic Acids; Protein Binding; Protein Structure, Tertiary; S-Adenosylhomocysteine; S-Adenosylmethionine; Species Specificity | 2009 |
Sinefungin-PLGA nanoparticles: drug loading, characterization, in vitro drug release and in vivo studies.
Topics: Adenosine; Animals; Delayed-Action Preparations; Drug Compounding; Lactic Acid; Male; Materials Testing; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar | 2009 |
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Topics: Adenosine; Azacitidine; Blotting, Western; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Keratin-7; Methylation; Molecular Structure; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2009 |
Discrimination between closely related cellular metabolites by the SAM-I riboswitch.
Topics: Adenosine; Base Pairing; Conserved Sequence; Crystallography, X-Ray; Kinetics; Models, Molecular; Mutation; Nucleic Acid Conformation; RNA, Bacterial; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089.
Topics: Adenosine; Antifungal Agents; Antiprotozoal Agents; Bacterial Proteins; Cell Culture Techniques; DNA-Directed RNA Polymerases; Genetic Enhancement; Mutagenesis, Site-Directed; Species Specificity; Streptomyces; Trypanosoma | 2010 |
Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus.
Topics: Adenosine; Animals; Dengue Virus; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Methylation; Methyltransferases; RNA; S-Adenosylmethionine; Viral Proteins | 2010 |
High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family.
Topics: Adenosine; Antiprotozoal Agents; Biological Transport; Biopterins; Blotting, Western; Cell Membrane; Drug Resistance, Bacterial; Folic Acid; Folic Acid Antagonists; Green Fluorescent Proteins; Leishmania; Membrane Transport Proteins; Methotrexate; Microscopy, Fluorescence; Mutation; Protozoan Proteins; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine | 2010 |
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Topics: Adenosine; Amino Acids; Bacillus subtilis; Binding Sites; Biotin; Carbon-Nitrogen Ligases; Crystallography, X-Ray; Metabolic Networks and Pathways; Mycobacterium tuberculosis; Protein Binding; Transaminases | 2010 |
Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin.
Topics: Adenosine; Amino Acids; Anti-Bacterial Agents; Bacterial Proteins; Binding Sites; Crystallography, X-Ray; Humans; Methanococcaceae; Protein Binding; Protein Conformation; Saccharomyces cerevisiae Proteins; tRNA Methyltransferases | 2010 |
Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
Topics: Adenosine; Amino Acid Sequence; Animals; Antifungal Agents; Binding Sites; Crystallography, X-Ray; Flavivirus; Humans; Methyltransferases; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Structure, Tertiary; RNA Caps; RNA, Viral; West Nile virus | 2010 |
Structural insights into the autoinhibition and posttranslational activation of histone methyltransferase SmyD3.
Topics: Adenosine; Amino Acid Sequence; Catalytic Domain; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Molecular Sequence Data; Protein Conformation; Protein Processing, Post-Translational; X-Ray Diffraction | 2011 |
Structure and mechanism of the chalcogen-detoxifying protein TehB from Escherichia coli.
Topics: Adenosine; Biocatalysis; Catalytic Domain; Chalcogens; Consensus Sequence; Crystallography, X-Ray; Drug Resistance, Bacterial; Escherichia coli K12; Escherichia coli Proteins; Kinetics; Methylation; Mutagenesis, Site-Directed; Mutant Proteins; Organoselenium Compounds; Protein Conformation; Recombinant Proteins; S-Adenosylhomocysteine; Sequence Alignment; Sequence Homology, Amino Acid; Tellurium | 2011 |
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex.
Topics: Adenosine; Crystallization; Magnesium; Methyltransferases; Mutation; Plasmids; Protein Binding; RNA Caps; RNA, Viral; S-Adenosylmethionine; Severe acute respiratory syndrome-related coronavirus; Viral Nonstructural Proteins | 2011 |
Pneumocystis S-adenosylmethionine transport: a potential drug target.
Topics: Adenosine; Animals; Antifungal Agents; Biological Transport; Drug Delivery Systems; Fungal Proteins; Humans; Methionine Adenosyltransferase; Pneumocystis carinii; Pneumonia, Pneumocystis; Recombinant Proteins; S-Adenosylmethionine; Saccharomyces cerevisiae | 2011 |
Structural and functional profiling of the human histone methyltransferase SMYD3.
Topics: Adenosine; Binding Sites; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship | 2011 |
Chemically-induced affinity star restriction specificity: a novel TspGWI/sinefungin endonuclease with theoretical 3-bp cleavage frequency.
Topics: Adenosine; Bacterial Proteins; Base Sequence; Binding Sites; Catalytic Domain; DNA; DNA Restriction Enzymes; Electrophoresis, Agar Gel; Methyltransferases; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; Thermus | 2011 |
Structure and reaction mechanism of phosphoethanolamine methyltransferase from the malaria parasite Plasmodium falciparum: an antiparasitic drug target.
Topics: Adenosine; Amino Acid Substitution; Antimalarials; Catalysis; Catalytic Domain; Crystallography, X-Ray; Drug Delivery Systems; Enzyme Inhibitors; Ethanolamines; Humans; Kinetics; Malaria, Falciparum; Methyltransferases; Mutation, Missense; Phosphorylcholine; Plasmodium falciparum; Protozoan Proteins | 2012 |
Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.
Topics: Adenosine; Azepines; Catalytic Domain; Chromatography, High Pressure Liquid; Fluorescent Dyes; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Kinetics; Protein Binding; Quinazolines; Recombinant Proteins; S-Adenosylhomocysteine; Tandem Mass Spectrometry; Time Factors | 2012 |
The BioC O-methyltransferase catalyzes methyl esterification of malonyl-acyl carrier protein, an essential step in biotin synthesis.
Topics: Adenosine; Adenosine Triphosphate; Amino Acid Sequence; Bacillus cereus; Bacterial Proteins; Biotin; Carrier Proteins; Chromatography, Gel; Conserved Sequence; Escherichia coli; Fatty Acids; Genetic Complementation Test; Hydrogen-Ion Concentration; Methionine; Molecular Sequence Data; Protein O-Methyltransferase; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2012 |
Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.
Topics: Adenosine; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Models, Molecular; Molecular Probes; Structure-Activity Relationship | 2012 |
A new genomic tool, ultra-frequently cleaving TaqII/sinefungin endonuclease with a combined 2.9-bp recognition site, applied to the construction of horse DNA libraries.
Topics: Adenosine; Animals; Deoxyribonucleases, Type II Site-Specific; DNA Cleavage; Genomic Library; Genomics; Horses; Substrate Specificity; Thermus | 2013 |
S-adenosyl-homocysteine is a weakly bound inhibitor for a flaviviral methyltransferase.
Topics: Adenosine; Cell Line; Enzyme Inhibitors; Flavivirus; Humans; Methyltransferases; Models, Molecular; Protein Binding; Protein Conformation; S-Adenosylhomocysteine; West Nile virus | 2013 |
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.
Topics: Adenosine; Amino Acids; Aminoglycosides; Biocatalysis; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Transfer, Horizontal; Methylation; Methyltransferases; Models, Molecular; Nucleotides; Protein Structure, Secondary; Protein Structure, Tertiary; Ribosome Subunits, Small, Bacterial; RNA, Ribosomal, 16S; Structure-Activity Relationship | 2014 |
Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumoniae biofilm growth.
Topics: Adenosine; Animals; Biofilms; Colony Count, Microbial; Gene Expression Regulation, Bacterial; Homocysteine; Otitis Media; Plankton; Rats, Sprague-Dawley; S-Adenosylmethionine; Streptococcus pneumoniae | 2014 |
Genetic mapping reveals that sinefungin resistance in Toxoplasma gondii is controlled by a putative amino acid transporter locus that can be used as a negative selectable marker.
Topics: Adenosine; Amino Acid Transport Systems; Antiprotozoal Agents; Drug Resistance; Genetic Linkage; Genetic Markers; Polymorphism, Single Nucleotide; Protozoan Proteins; Quantitative Trait Loci; Selection, Genetic; Toxoplasma | 2015 |
Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
Topics: Adenosine; Amino Acid Sequence; Anticodon; Base Sequence; Binding Sites; Biocatalysis; Crystallography, X-Ray; Escherichia coli Proteins; Guanine; Haemophilus influenzae; Kinetics; Methylation; Models, Molecular; Molecular Sequence Data; RNA, Transfer; S-Adenosylmethionine; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima; tRNA Methyltransferases | 2015 |
Leishmania major phosphoglycerate kinase transcript and protein stability contributes to differences in isoform expression levels.
Topics: Adenosine; Antiprotozoal Agents; Cycloheximide; Cytosol; Dactinomycin; Gene Expression Regulation; Half-Life; Immunoblotting; Isoenzymes; Leishmania major; Microbodies; Molecular Weight; Phosphoglycerate Kinase; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Protozoan; Transcription, Genetic | 2015 |
The Use of Nucleosome Substrates Improves Binding of SAM Analogs to SETD8.
Topics: Adenosine; DNA Damage; High-Throughput Screening Assays; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Nucleosomes; Peptides; PR-SET Domains; Protein Binding; Structure-Activity Relationship; Substrate Specificity | 2016 |
Structure of the Epigenetic Oncogene MMSET and Inhibition by N-Alkyl Sinefungin Derivatives.
Topics: Adenosine; Binding Sites; Calorimetry; Chromatography, Liquid; Crystallography, X-Ray; Drug Design; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oncogenes; Protein Conformation; Repressor Proteins | 2016 |
Structural basis of Zika virus methyltransferase inhibition by sinefungin.
Topics: Adenosine; Binding Sites; Enzyme Inhibitors; Methyltransferases; Models, Molecular; Protein Binding; Zika Virus | 2017 |
A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.
Topics: Adenosine; Drug Evaluation, Preclinical; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Methylation; Pyrrolidines; Small Molecule Libraries; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Tetrahydroisoquinolines | 2017 |
Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine.
Topics: Adenosine; Binding Sites; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; Models, Molecular; Mutation; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Pseudouridine; RNA, Ribosomal, 23S; S-Adenosylmethionine; Substrate Specificity | 2017 |
QTL Mapping and CRISPR/Cas9 Editing to Identify a Drug Resistance Gene in Toxoplasma gondii.
Topics: Adenosine; Antiprotozoal Agents; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Cas Systems; DNA Breaks, Double-Stranded; Drug Resistance; Endonucleases; Genes, Protozoan; Genome, Protozoan; Quantitative Trait Loci; RNA, Guide, Kinetoplastida; Toxoplasma | 2017 |
Cycloalkane analogues of sinefungin as EHMT1/2 inhibitors.
Topics: Adenosine; Alkanes; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Inhibitory Concentration 50; Structure-Activity Relationship | 2017 |
Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis.
Topics: Adenosine; Animals; Cells, Cultured; Collagen Type I; Dialysis Solutions; Epithelium; Gene Expression Regulation; Glucose; Histone Code; Histone-Lysine N-Methyltransferase; Humans; Male; Methylation; Mice; Mice, Inbred C57BL; Nitrogen; Omentum; Peritoneal Dialysis; Peritoneal Fibrosis; Promoter Regions, Genetic; Pyruvaldehyde; Transforming Growth Factor beta1 | 2018 |
A panoptic uncovering of the dynamical evolution of the Zika Virus NS5 methyltransferase binding site loops-zeroing in on the molecular landscape.
Topics: Adenosine; Binding Sites; Databases, Protein; Enzyme Inhibitors; Hydrogen Bonding; Methyltransferases; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Structure, Tertiary; Thermodynamics; Viral Nonstructural Proteins; Zika Virus | 2018 |
Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme.
Topics: Adenosine; Antiviral Agents; Aurintricarboxylic Acid; Cations, Divalent; Chikungunya virus; Coenzymes; Drug Evaluation, Preclinical; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Inhibitory Concentration 50; Magnesium; Methyltransferases; Ribavirin; Viral Proteins | 2018 |
Design, synthesis and in vitro anti-Zika virus evaluation of novel Sinefungin derivatives.
Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Drug; Drug Design; Microbial Sensitivity Tests; Molecular Structure; Phenylurea Compounds; Structure-Activity Relationship; Zika Virus | 2018 |
Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.
Topics: Adenosine; Antiviral Agents; Cytidine Triphosphate; Half-Life; HEK293 Cells; Humans; Immunity, Innate; Interleukin-1 Receptor-Associated Kinases; Intracellular Signaling Peptides and Proteins; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Protein Binding; Proteins; S-Adenosylmethionine; Signal Transduction; TNF Receptor-Associated Factor 6; Ubiquitination | 2019 |
Abrogation of myofibroblast activities in metastasis and fibrosis by methyltransferase inhibition.
Topics: Adenosine; Animals; Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Transdifferentiation; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Deletion; Humans; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Methyltransferases; Mice; Myofibroblasts; Snail Family Transcription Factors; Transforming Growth Factor beta; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2019 |
Hit identification of SMYD3 enzyme inhibitors using structure-based pharmacophore modeling.
Topics: Adenosine; Algorithms; Drug Discovery; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Molecular Docking Simulation; Small Molecule Libraries; Structure-Activity Relationship | 2019 |
Antiviral effect of sinefungin on in vitro growth of feline herpesvirus type 1.
Topics: Adenosine; Animals; Antiviral Agents; Calicivirus, Feline; Cat Diseases; Cats; Cell Line; Coronavirus, Feline; Dose-Response Relationship, Drug; Herpesviridae Infections; Herpesvirus 1, Equid; Herpesvirus 1, Suid; Horses; Kidney; Toxicity Tests; Varicellovirus | 2019 |
Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin.
Topics: Adenosine; Betacoronavirus; Catalytic Domain; Coronavirus Infections; COVID-19; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Methyltransferases; Models, Chemical; Models, Molecular; Pandemics; Pneumonia, Viral; RNA Caps; RNA Stability; RNA, Viral; SARS-CoV-2; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins | 2020 |
High-resolution structures of the SARS-CoV-2 2'-
Topics: Adenosine; Betacoronavirus; Binding Sites; Catalytic Domain; Coronavirus Infections; COVID-19; Crystallography, X-Ray; Dimerization; Genes, Viral; Humans; Methylation; Methyltransferases; Models, Molecular; Open Reading Frames; Pandemics; Pneumonia, Viral; Protein Binding; Protein Conformation; RNA Cap Analogs; RNA Processing, Post-Transcriptional; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; SARS-CoV-2; Structure-Activity Relationship; Viral Nonstructural Proteins | 2020 |
A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19.
Topics: Adenosine; Antiviral Agents; Binding, Competitive; COVID-19; COVID-19 Drug Treatment; Enzyme Inhibitors; Fluorescence Polarization; Gene Expression Regulation; High-Throughput Screening Assays; Host-Pathogen Interactions; Humans; Methyltransferases; Protein Binding; RNA Caps; RNA, Viral; SARS-CoV-2; Signal Transduction; Small Molecule Libraries; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins; Virus Replication | 2021 |
In silico identification of novel SARS-COV-2 2'-O-methyltransferase (nsp16) inhibitors: structure-based virtual screening, molecular dynamics simulation and MM-PBSA approaches.
Topics: Adenosine; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Databases, Pharmaceutical; Databases, Protein; Drug Stability; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Kinetics; Methyltransferases; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; SARS-CoV-2; Thermodynamics; Viral Nonstructural Proteins | 2021 |
Multiple mutations in RNA polymerase β-subunit gene (rpoB) in Streptomyces incarnatus NRRL8089 enhance production of antiviral antibiotic sinefungin: modeling rif cluster region by density functional theory.
Topics: Adenosine; Amino Acid Substitution; Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Antiprotozoal Agents; Antiviral Agents; Bacterial Proteins; Binding Sites; Density Functional Theory; DNA; DNA-Directed RNA Polymerases; Gene Expression Regulation, Bacterial; Molecular Dynamics Simulation; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; RNA, Messenger; Streptomyces | 2021 |
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.
Topics: Adenosine; Cloning, Molecular; COVID-19; Enzyme Assays; Enzyme Inhibitors; Escherichia coli; Gene Expression; Genetic Vectors; High-Throughput Screening Assays; Humans; Kinetics; Methylation; Methyltransferases; Models, Molecular; Recombinant Proteins; RNA Caps; RNA, Viral; SARS-CoV-2; Tritium; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins | 2021 |