Compounds > adenosine-5--(n-ethylcarboxamide)

adenosine-5--(n-ethylcarboxamide) and aristeromycin

adenosine-5--(n-ethylcarboxamide) has been researched along with aristeromycin* in 2 studies

Other Studies

2 other study(ies) available for adenosine-5--(n-ethylcarboxamide) and aristeromycin

Article	Year
Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications. Bioorganic & medicinal chemistry letters, 2001, May-21, Volume: 11, Issue:10 Novel methanocarba adenosine analogues, having the pseudo-ribose northern (N) conformation preferred at adenosine receptors (ARs), were synthesized and tested in binding assays. The 5'-uronamide modification preserved [N6-(3-iodobenzyl)] or enhanced (N6-methyl) affinity at A3ARs, while the 2'-deoxy modification reduced affinity and efficacy in a functional assay. Topics: Adenine; Adenosine; Animals; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cyclopentanes; Humans; Nucleosides; Protein Binding; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection	2001
Hypotensive and renal vasodilator effects of carbocyclic adenosine (aristeromycin) in anesthetized spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:3 Systemic arterial pressure and renal blood flow were measured in pentobarbital-anesthetized spontaneously hypertensive rats to assess the influence and mechanism of action of metabolically stable adenosine analogs on renal hemodynamics. (-)-Aristeromycin (carbocyclic adenosine; CA), a model carbocyclic nucleoside, was characterized with respect to adenosine receptor pharmacology by comparison to the effects elicited by the prototypic adenosine analogs 5'-N-ethylcarboxamide adenosine (NECA; an adenosine A1 and A2 receptor agonist) and N6-cyclohexyl adenosine (an adenosine A1 agonist). Intravenous bolus injections of CA and NECA caused dose-dependent hypotension and renal vasodilatation. Although CA and NECA were equally efficacious hypotensive agents, NECA was approximately 100-fold more potent than CA. CA was a more efficacious renal vasodilator than NECA. In contrast, at doses which had minimal effects on systemic arterial pressure, N6-cyclohexyl adenosine decreased renal blood flow. The hypotensive and renovascular effects of the adenosine analogs but not those of a control vasodilator, methacholine, were attenuated by i.v. administration of the xanthines aminophylline and 8-phenyltheophylline; thus, the effects of the nucleosides on renal blood flow in vivo appear to be attributable in part to activation of adenosine receptors. The profile of cardiovascular effects caused by CA suggests that this agent acts primarily as an adenosine A2 receptor agonist. Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aminophylline; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Male; Rats; Rats, Inbred SHR; Receptors, Cell Surface; Receptors, Purinergic; Renal Circulation; Vasodilator Agents	1986

Article

Year

Ring-Constrained (N)-methanocarba nucleosides as adenosine receptor agonists: independent 5'-uronamide and 2'-deoxy modifications.

Bioorganic & medicinal chemistry letters, 2001, May-21, Volume: 11, Issue:10

Novel methanocarba adenosine analogues, having the pseudo-ribose northern (N) conformation preferred at adenosine receptors (ARs), were synthesized and tested in binding assays. The 5'-uronamide modification preserved [N6-(3-iodobenzyl)] or enhanced (N6-methyl) affinity at A3ARs, while the 2'-deoxy modification reduced affinity and efficacy in a functional assay.

Topics: Adenine; Adenosine; Animals; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Cricetinae; Cyclopentanes; Humans; Nucleosides; Protein Binding; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Transfection

2001

Hypotensive and renal vasodilator effects of carbocyclic adenosine (aristeromycin) in anesthetized spontaneously hypertensive rats.

The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:3

Systemic arterial pressure and renal blood flow were measured in pentobarbital-anesthetized spontaneously hypertensive rats to assess the influence and mechanism of action of metabolically stable adenosine analogs on renal hemodynamics. (-)-Aristeromycin (carbocyclic adenosine; CA), a model carbocyclic nucleoside, was characterized with respect to adenosine receptor pharmacology by comparison to the effects elicited by the prototypic adenosine analogs 5'-N-ethylcarboxamide adenosine (NECA; an adenosine A1 and A2 receptor agonist) and N6-cyclohexyl adenosine (an adenosine A1 agonist). Intravenous bolus injections of CA and NECA caused dose-dependent hypotension and renal vasodilatation. Although CA and NECA were equally efficacious hypotensive agents, NECA was approximately 100-fold more potent than CA. CA was a more efficacious renal vasodilator than NECA. In contrast, at doses which had minimal effects on systemic arterial pressure, N6-cyclohexyl adenosine decreased renal blood flow. The hypotensive and renovascular effects of the adenosine analogs but not those of a control vasodilator, methacholine, were attenuated by i.v. administration of the xanthines aminophylline and 8-phenyltheophylline; thus, the effects of the nucleosides on renal blood flow in vivo appear to be attributable in part to activation of adenosine receptors. The profile of cardiovascular effects caused by CA suggests that this agent acts primarily as an adenosine A2 receptor agonist.

Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Aminophylline; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Male; Rats; Rats, Inbred SHR; Receptors, Cell Surface; Receptors, Purinergic; Renal Circulation; Vasodilator Agents

1986