adenophostin a has been researched along with inositol 1,4,5-trisphosphate in 56 studies
| Studies (adenophostin a) | Trials (adenophostin a) | Recent Studies (post-2010) (adenophostin a) | Studies (inositol 1,4,5-trisphosphate) | Trials (inositol 1,4,5-trisphosphate) | Recent Studies (post-2010) (inositol 1,4,5-trisphosphate) |
|---|---|---|---|---|---|
| 92 | 0 | 12 | 6,600 | 1 | 589 |
| Protein | Taxonomy | adenophostin a (IC50) | inositol 1,4,5-trisphosphate (IC50) |
|---|---|---|---|
| Inositol-trisphosphate 3-kinase A | Rattus norvegicus (Norway rat) | 4.45 | |
| Inositol 1,4,5-trisphosphate receptor type 2 | Homo sapiens (human) | 0.03 | |
| Inositol 1,4,5-trisphosphate receptor type 3 | Homo sapiens (human) | 0.03 | |
| Inositol 1,4,5-trisphosphate receptor type 1 | Homo sapiens (human) | 0.03 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (33.93) | 18.2507 |
| 2000's | 26 (46.43) | 29.6817 |
| 2010's | 10 (17.86) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| Correa, V; Mahon, MF; Potter, BV; Riley, AM; Taylor, CW | 1 |
| Abe, H; Dedos, SG; Matsuda, A; Paul, M; Potter, BV; Shuto, S; Taylor, CW; Terauchi, M; Tovey, SC; Trusselle, M | 1 |
| Abe, H; Dedos, SG; Kondo, Y; Matsuda, A; Mochizuki, T; Paul, M; Potter, BV; Shuto, S; Taylor, CW; Tovey, SC | 1 |
| Dellis, O; Potter, BV; Rahman, T; Riley, AM; Rossi, AM; Taylor, CW; Taylor, EJ; Tovey, SC; Veresov, VG | 1 |
| Potter, BV; Riley, AM; Sureshan, KM; Taylor, CW; Thomas, MP; Tovey, SC | 1 |
| Brearley, CA; Potter, BVL; Riley, AM; Rossi, AM; Shipton, ML; Taylor, CW | 1 |
| Erneux, C; Gigg, R; Nahorski, SR; Primrose, WU; Wilcox, RA | 2 |
| Chen, CS; Gou, DM; Lu, PJ; Shieh, WR | 1 |
| Hosoya, T; Kagasaki, T; Takahashi, M; Takahashi, S | 1 |
| Takahashi, M; Takahashi, S; Tanzawa, K | 1 |
| Hotoda, H; Kaneko, M; Miyamoto, S; Takahashi, M; Takahashi, S; Tanzawa, K | 1 |
| Bonnett, C; DeLisle, S; Jenkins, DJ; Marksberry, EW; Potter, BV; Takahashi, M; Tanzawa, K | 1 |
| Hartzell, HC; Hirayama, Y; Machaca, K | 1 |
| Beecroft, MD; Jenkins, DJ; Marchant, JS; Marwood, RD; Potter, BV; Riley, AM; Taylor, CW | 1 |
| Jenkins, DJ; Lindley, CJ; Murphy, CT; Potter, BV; Riley, AM; Westwick, J | 1 |
| De Smedt, H; Kunzelmann, K; Maes, K; Missiaen, L; Parys, JB; Sienaert, I; Takahashi, M; Tanzawa, K | 1 |
| Marchant, JS; Parker, I | 1 |
| Huang, Y; Putney, JW; Takahashi, M; Tanzawa, K | 1 |
| Hartzell, HC; Machaca, K | 1 |
| Correa, V; Marwood, RD; Potter, BV; Riley, AM; Taylor, CW | 1 |
| Hotoda, H; Iwata, Y; Kaneko, M; Kawase, Y; Miyamoto, S; Murayama, K; Takahashi, M; Tanzawa, K | 1 |
| Damiani, P; Ducibella, T; Fissore, RA; He, CL; Parys, JB; Takahashi, M; Tanzawa, K | 1 |
| Armstrong, DL; Broad, LM; Putney, JW | 1 |
| Felemez, M; Marwood, RD; Potter, BV; Spiess, B | 1 |
| Boehning, D; Joseph, SK | 1 |
| Fissore, RA; He, CL; Jellerette, T; Parys, JB; Wu, H | 1 |
| Abe, H; Matsuda, A; Shuto, S | 1 |
| Correa, V; de Kort, M; Potter, BV; Taylor, CW; Valentijn, AR; van Boom, JH; van der Marel, GA | 1 |
| Correa, V; Jenkins, DJ; Marwood, RD; Potter, BV; Taylor, CW | 1 |
| Correa, V; Potter, BV; Riley, AM; Rosenberg, HJ; Taylor, CW | 1 |
| Adkins, CE; Potter, BV; Taylor, CW; Wissing, F | 1 |
| Csordás, G; Hajnóczky, G | 1 |
| Foskett, JK; Mak, DO; McBride, S | 1 |
| Allbritton, NL; Black, SL; Fissore, RA; Fukami, K; Luzzi, V; Smyth, J; Takenawa, T; Wu, H | 1 |
| Morris, SA; Swatton, JE; Taylor, CW; Wissing, F | 1 |
| Akaike, A; Kaneko, S; Kanki, H; Kinoshita, M; Mori, Y; Satoh, M | 1 |
| Parekh, AB; Potter, BV; Riley, AM | 1 |
| Chapleur, Y; Chrétien, F; Hilly, M; Mauger, JP; Moitessier, N; Roussel, F | 1 |
| Koganezawa, M; Shimada, I | 1 |
| Exley, GE; Fissore, R; Gordo, AC; Jellerette, T; Kurokawa, M; Rodrigues, P; Warner, C | 1 |
| Cadiou, H; Molle, G | 1 |
| Dozol, H; Graff, R; Maechling, C; Matsuda, A; Shuto, S; Spiess, B | 1 |
| Anderson, CD; Belous, AE; Chari, RS; Knox, CD; Nicoud, IB; Pierce, JM; Pinson, CW; Wakata, A | 1 |
| Hirose, S; Kaneko, S; Okada, M; Yoshida, S; Zhu, G | 1 |
| Fissore, RA; He, C; Knott, JG; Malcuit, C; Parys, JB; Robl, JM; Wainwright, T | 1 |
| Dietz, RV; Kelly, PT; Mackinnon, RL; Maher, BJ; Wang, J | 1 |
| Fissore, RA; Lee, B; Malcuit, C; Parys, JB; Yoon, SY | 1 |
| Ding, Z; Potter, BV; Rahman, T; Riley, AM; Rossi, AM; Taylor, CW | 1 |
| Potter, VL; Riley, AM; Rossi, AM; Sureshan, KM; Taylor, CW | 1 |
| Araki, M; Nagayama, T | 1 |
| Potter, BV; Riley, AM; Saleem, H; Taylor, CW; Tovey, SC | 1 |
| Orsinger, GV; Romanowski, M; Williams, JD | 1 |
| Mills, SJ; Potter, BV; Riley, AM; Swarbrick, JM | 1 |
| Arisawa, M; Morita, T; Murata, K; Nezu, A; Oura, T; Shuto, S; Tanimura, A | 1 |
| Alzayady, KJ; Bultynck, G; De Smedt, H; Hamada, K; Ivanova, H; Luyten, T; Martens, L; Mikoshiba, K; Parys, JB; Tanimura, A; Vandermarliere, E; Wagner, LE; Wang, L; Welkenhuyzen, K; Yule, DI | 1 |
1 review(s) available for adenophostin a and inositol 1,4,5-trisphosphate
| Article | Year |
|---|---|
Designer small molecules to target calcium signalling.
Topics: Adenosine; Adenosine Diphosphate Ribose; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Calcium Signaling; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; NADP; Ryanodine Receptor Calcium Release Channel; Small Molecule Libraries; Structure-Activity Relationship | 2015 |
55 other study(ies) available for adenophostin a and inositol 1,4,5-trisphosphate
| Article | Year |
|---|---|
Bicyclic analogues of D-myo-inositol 1,4,5-trisphosphate related to adenophostin A: synthesis and biological activity.
Topics: Adenosine; Animals; Calcium; Calcium Channel Agonists; Chromatography, Thin Layer; Crystallography, X-Ray; Hepatocytes; In Vitro Techniques; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Kinetics; Liver; Membranes; Models, Molecular; Molecular Conformation; Rats; Spectrophotometry, Ultraviolet; Stereoisomerism | 2001 |
A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy.
Topics: Animals; Binding Sites; Calcium; Calcium Channels; Cell Line; Chickens; Cyclization; Glucosides; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Models, Molecular; Molecular Conformation; Organophosphates; Oxidation-Reduction; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Silanes; Structure-Activity Relationship | 2006 |
Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands.
Topics: Adenosine; Animals; Calcium; Calcium Channels; Cell Line; Chickens; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Models, Molecular; Molecular Conformation; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2006 |
Synthetic partial agonists reveal key steps in IP3 receptor activation.
Topics: Animals; Binding Sites; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Ligands; Models, Molecular; Molecular Sequence Data; Point Mutation; Protein Binding; Protein Conformation | 2009 |
Contribution of phosphates and adenine to the potency of adenophostins at the IP₃ receptor: synthesis of all possible bisphosphates of adenophostin A.
Topics: Adenine; Adenosine; Animals; Calcium; Cell Line; Chickens; Inositol 1,4,5-Trisphosphate Receptors; Models, Molecular; Organophosphates; Rats; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship | 2012 |
Both d- and l-Glucose Polyphosphates Mimic d-
Topics: Animals; Dose-Response Relationship, Drug; Drug Partial Agonism; Glucose; HEK293 Cells; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Molecular Docking Simulation; Molecular Mimicry; Polyphosphates; Protein Structure, Secondary; Rats; Rats, Wistar | 2020 |
2-Hydroxyethyl-alpha-D-glucopyranoside-2,3',4'-trisphosphate, a novel, metabolically resistant, adenophostin A and myo-inositol-1,4,5-trisphosphate analogue, potently interacts with the myo-inositol-1,4,5-trisphosphate receptor.
Topics: Adenosine; Calcium; Calcium Channels; Computer Simulation; Glucosides; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Polyphosphate 5-Phosphatases; Ion Transport; Molecular Conformation; Neuroblastoma; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Tumor Cells, Cultured | 1995 |
Molecular interactions of endogenous D-myo-inositol phosphates with the intracellular D-myo-inositol 1,4,5-trisphosphate recognition site.
Topics: Adenosine; Animals; Binding, Competitive; Calcium; Calcium Channels; Cerebellum; Dose-Response Relationship, Drug; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Phosphates; Ligands; Microsomes; Rats; Receptors, Cytoplasmic and Nuclear; Stereoisomerism | 1994 |
Adenophostins A and B: potent agonists of inositol-1,4,5-trisphosphate receptor produced by Penicillium brevicompactum. Taxonomy, fermentation, isolation, physico-chemical and biological properties.
Topics: Adenine; Adenosine; Animals; Calcium Channels; Chromatography, High Pressure Liquid; Fermentation; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Mice; Penicillium; Receptors, Cytoplasmic and Nuclear | 1993 |
Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.
Topics: Adenosine; Animals; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cerebellum; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Polyphosphate 5-Phosphatases; Penicillium; Phosphoric Monoester Hydrolases; Phosphotransferases (Alcohol Group Acceptor); Rats; Receptors, Cytoplasmic and Nuclear | 1994 |
2-Hydroxyethyl alpha-D-glucopyranoside 2,3',4'-trisphosphate: a novel metabolically resistant adenophostin A and myo-inositol 1,4,5-trisphosphate analogue potently interacts with the myo-inositol 1,4,5-trisphosphate receptor.
Topics: Adenosine; Animals; Binding Sites; Calcium Channels; Cell Line; Cerebellum; Glucosides; Humans; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Molecular Probes; Receptors, Cytoplasmic and Nuclear; Swine | 1995 |
IP3 receptor-ligand. 2: Synthesis and molecular mechanics calculation of adenophostin A.
Topics: Adenosine; Calcium Channels; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Methods; Molecular Conformation; Molecular Structure; Receptors, Cytoplasmic and Nuclear; Thermodynamics | 1995 |
Adenophostin A can stimulate Ca2+ influx without depleting the inositol 1,4,5-trisphosphate-sensitive Ca2+ stores in the Xenopus oocyte.
Topics: Adenosine; Animals; Calcium; Cell Compartmentation; Female; Inositol 1,4,5-Trisphosphate; Manganese; Oocytes; Xenopus | 1997 |
Effects of adenophostin-A and inositol-1,4,5-trisphosphate on Cl- currents in Xenopus laevis oocytes.
Topics: Adenosine; Animals; Calcium; Calcium Channels; Chloride Channels; Chlorides; Inositol 1,4,5-Trisphosphate; Membrane Potentials; Oocytes; Xenopus laevis | 1997 |
Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptors.
Topics: Adenosine; Animals; Binding, Competitive; Calcium Channels; Cell Membrane; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Liver; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Sugar Phosphates | 1997 |
Structural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: recognition by cerebellar and platelet inositol-1,4,5-trisphosphate receptors.
Topics: Adenosine; Animals; Blood Platelets; Calcium; Calcium Channels; Cell Membrane Permeability; Cerebellum; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear; Spectrometry, Fluorescence; Tritium | 1997 |
Functional properties of the type-3 InsP3 receptor in 16HBE14o- bronchial mucosal cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Aorta; Bronchi; Calcium; Calcium Channels; Cell Line; Cell Membrane Permeability; Cytosol; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Mucous Membrane; Polymerase Chain Reaction; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thimerosal; Transcription, Genetic | 1998 |
Kinetics of elementary Ca2+ puffs evoked in Xenopus oocytes by different Ins(1,4,5)P3 receptor agonists.
Topics: Adenosine; Animals; Calcium Channels; Calcium Signaling; Cerebellum; Female; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Phosphates; Kinetics; Microscopy, Confocal; Oocytes; Rats; Receptors, Cytoplasmic and Nuclear; Xenopus laevis | 1998 |
Effect of adenophostin A on Ca2+ entry and calcium release-activated calcium current (Icrac) in rat basophilic leukemia cells.
Topics: Adenosine; Animals; Barium; Calcium; Calcium Channels; Egtazic Acid; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Kinetics; Leukemia, Basophilic, Acute; Rats; Time Factors; Tumor Cells, Cultured | 1998 |
Adenophostin A and inositol 1,4,5-trisphosphate differentially activate Cl- currents in Xenopus oocytes because of disparate Ca2+ release kinetics.
Topics: Adenosine; Animals; Base Sequence; Calcium; Calcium Channels; Chloride Channel Agonists; DNA Primers; Female; Fluorescent Dyes; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Microscopy, Confocal; Oocytes; Receptors, Cytoplasmic and Nuclear; Xenopus laevis | 1999 |
Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of D-myo-inositol 1,4,5-trisphosphate.
Topics: Adenosine; Animals; Calcium; Carbohydrate Conformation; Cells, Cultured; Furans; Glucosephosphates; Glycosides; Inositol 1,4,5-Trisphosphate; Liver; Molecular Mimicry; Rats | 1999 |
Molecular recognition of adenophostin, a very potent Ca2+ inducer, at the D-myo-inositol 1,4,5-trisphosphate receptor.
Topics: Adenosine; Animals; Binding Sites; Calcium; Calcium Channels; Cerebellum; Glucosides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Microsomes; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Penicillium; Rats; Receptors, Cytoplasmic and Nuclear | 1999 |
Isoforms of the inositol 1,4,5-trisphosphate receptor are expressed in bovine oocytes and ovaries: the type-1 isoform is down-regulated by fertilization and by injection of adenophostin A.
Topics: Adenosine; Animals; Blotting, Western; Calcium; Calcium Channels; Cattle; Down-Regulation; Female; Fertilization; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Oocytes; Ovary; Receptors, Cytoplasmic and Nuclear | 1999 |
Role of the inositol 1,4,5-trisphosphate receptor in Ca(2+) feedback inhibition of calcium release-activated calcium current (I(crac)).
Topics: Adenosine; Animals; Calcium; Calcium Channels; Enzyme Inhibitors; Feedback; Fluorescence; Fura-2; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Phosphates; Ionomycin; Ionophores; Patch-Clamp Techniques; Rats; Receptors, Cytoplasmic and Nuclear; Thapsigargin; Tumor Cells, Cultured | 1999 |
Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.
Topics: Adenosine; Calcium; Hydrogen-Ion Concentration; Inositol 1,4,5-Trisphosphate; Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Structure; Protons | 1999 |
Functional properties of recombinant type I and type III inositol 1, 4,5-trisphosphate receptor isoforms expressed in COS-7 cells.
Topics: Adenosine; Amino Acid Substitution; Animals; Calcimycin; Calcium; Calcium Channels; Calcium-Transporting ATPases; Cell Membrane Permeability; COS Cells; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Kinetics; Microsomes; Mutagenesis, Site-Directed; Neurons; Protein Isoforms; Rats; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Transfection | 2000 |
Down-regulation of the inositol 1,4,5-trisphosphate receptor in mouse eggs following fertilization or parthenogenetic activation.
Topics: Adenosine; Animals; Calcium Channel Agonists; Calcium Channels; Calcium Signaling; Cellular Senescence; Cysteine Endopeptidases; Down-Regulation; Ethanol; Fertilization; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Multienzyme Complexes; Ovum; Parthenogenesis; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Spermatozoa; Strontium; Subcellular Fractions; Swine; Thimerosal | 2000 |
Synthesis of the C-glycosidic analogue of adenophostin A and its uracil congener as potential IP(3) receptor ligands. Stereoselective construction of the C-glycosidic structure by a temporary silicon-tethered radical coupling reaction.
Topics: Adenosine; Calcium Channels; Glycosides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Models, Molecular; Molecular Conformation; Receptors, Cytoplasmic and Nuclear; Structure-Activity Relationship; Uracil | 2000 |
Synthesis of potent agonists of the D-myo-inositol 1,4, 5-trisphosphate receptor based on clustered disaccharide polyphosphate analogues of adenophostin A.
Topics: Adenosine; Animals; Binding, Competitive; Calcium; Calcium Channels; Disaccharides; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Liver; Male; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Sea Urchins; Structure-Activity Relationship | 2000 |
Contribution of the adenine base to the activity of adenophostin A investigated using a base replacement strategy.
Topics: Adenine; Adenosine; Animals; Calcium; Calcium Channel Agonists; Calcium Channels; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Liver; Magnetic Resonance Spectroscopy; Membranes; Radioligand Assay; Rats; Receptors, Cytoplasmic and Nuclear; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship | 2000 |
C-glycoside based mimics of D-myo-inositol 1,4,5-trisphosphate.
Topics: Adenosine; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Calcium Signaling; Dose-Response Relationship, Drug; Glucose; Glycosides; Hepatocytes; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Molecular Mimicry; Rats; Receptors, Cytoplasmic and Nuclear | 2000 |
Rapid activation and partial inactivation of inositol trisphosphate receptors by adenophostin A.
Topics: Adenosine; Animals; Calcium; Calcium Channel Agonists; Calcium Channels; Calcium Signaling; Cell Membrane Permeability; Hepatocytes; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Kinetics; Male; Protein Binding; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear | 2000 |
Sorting of calcium signals at the junctions of endoplasmic reticulum and mitochondria.
Topics: Adenosine; Animals; Calcium; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Cells, Cultured; Cytosol; Endoplasmic Reticulum; Fluorometry; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Microscopy, Confocal; Mitochondria; Receptors, Cytoplasmic and Nuclear | 2001 |
ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cells.
Topics: Adenosine; Adenosine Triphosphate; Animals; Binding Sites; Calcium Channel Agonists; Calcium Channels; Calcium Signaling; Cytoplasm; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Kinetics; Ligands; Oocytes; Patch-Clamp Techniques; Receptors, Cytoplasmic and Nuclear; Xenopus | 2001 |
Sperm factor induces intracellular free calcium oscillations by stimulating the phosphoinositide pathway.
Topics: Adenosine; Alternative Splicing; Animals; Biological Factors; Blotting, Western; Calcium; Calcium Chloride; Cytosol; Enzyme Activation; Enzyme Inhibitors; Estrenes; Female; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Microinjections; Oocytes; Phosphatidylinositols; Pyrrolidinones; Semen; Swine; Testis; Tissue Extracts; Type C Phospholipases; Xenopus | 2001 |
Functional properties of Drosophila inositol trisphosphate receptors.
Topics: Adenosine; Animals; Binding, Competitive; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Drosophila; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Inositol Phosphates; Intracellular Fluid; Kinetics; Mammals; Receptors, Cytoplasmic and Nuclear | 2001 |
Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channels.
Topics: Acetylcholine; Adenosine; Allosteric Regulation; Animals; Calcium; Calcium Channel Agonists; Calcium Channels; Cation Transport Proteins; Electrophysiology; Estrenes; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Mice; Nuclear Proteins; Oligodeoxyribonucleotides, Antisense; Oocytes; Oxazoles; Peptides; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyrrolidinones; Receptor, Muscarinic M1; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; TRPC Cation Channels; Type C Phospholipases; Xenopus laevis | 2001 |
Adenophostin A and ribophostin, but not inositol 1,4,5-trisphosphate or manno-adenophostin, activate the Ca2+ release-activated Ca2+ current, I(CRAC), in weak intracellular Ca2+ buffer.
Topics: Adenosine; Adenosine Triphosphate; Animals; Buffers; Calcium Channel Agonists; Calcium Channels; Calcium Signaling; Disaccharides; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Intracellular Fluid; Mitochondria; Patch-Clamp Techniques; Rats; Sugar Phosphates; Tumor Cells, Cultured | 2002 |
D-myo-inositol-1,4,5-trisphosphate and adenophostin mimics: importance of the spatial orientation of a phosphate group on the biological activity.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Calcium Channel Agonists; Calcium Channels; Hepatocytes; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Microsomes; Molecular Conformation; Molecular Mimicry; Phosphates; Rats; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Structure-Activity Relationship | 2002 |
Inositol 1,4,5-trisphosphate transduction cascade in taste reception of the fleshfly, Boettcherisca peregrina.
Topics: Adenosine; Animals; Animals, Genetically Modified; Calcium Channel Agonists; Calcium Channels; Deoxycholic Acid; Detergents; Diptera; Drosophila melanogaster; Drosophila Proteins; Estrenes; Gene Expression; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Neomycin; Nerve Tissue Proteins; Paired Box Transcription Factors; Phosphatidylinositol Diacylglycerol-Lyase; Phosphodiesterase Inhibitors; Phospholipase C beta; Protein Synthesis Inhibitors; Pyrrolidinones; Receptors, Cytoplasmic and Nuclear; Ruthenium Red; Signal Transduction; Taste; Transcription Factors; Type C Phospholipases | 2002 |
Intracellular calcium oscillations signal apoptosis rather than activation in in vitro aged mouse eggs.
Topics: Adenosine; Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Chorionic Gonadotropin; Female; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Oocytes; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sperm Injections, Intracytoplasmic; Time Factors | 2002 |
Adenophostin A and imipramine are two activators of the olfactory inositol 1,4,5-trisphosphate-gated channel in fish olfatory cilia.
Topics: Adenosine; Animals; Carps; Cells, Cultured; Cilia; Enzyme Activation; Imipramine; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Ion Channels; Lipid Bilayers; Membrane Potentials; Nasal Mucosa; Olfactory Receptor Neurons; Type C Phospholipases | 2003 |
Conformational and inframolecular studies of the protonation of adenophostin analogues lacking the adenine moiety.
Topics: Adenine; Adenosine; Bacterial Proteins; Calcium Channel Agonists; Inositol 1,4,5-Trisphosphate; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phosphorus; Phosphorylation; Protein Conformation; Protons | 2004 |
Novel role of phospholipase C-delta1: regulation of liver mitochondrial Ca2+ uptake.
Topics: Adenosine; Animals; Blotting, Western; Calcium; Calcium Channel Agonists; Calcium Channels; Calcium-Binding Proteins; Cell Membrane; Estrenes; Fluorescent Dyes; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Microscopy, Fluorescence; Mitochondria, Liver; Phosphodiesterase Inhibitors; Phospholipase C delta; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Spermine; Stimulation, Chemical; Type C Phospholipases | 2004 |
Both 3,4-dihydroxyphenylalanine and dopamine releases are regulated by Ca2+-induced Ca2+ releasing system in rat striatum.
Topics: Adenosine; Analysis of Variance; Animals; Calcium; Calcium Channels; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Electrochemistry; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Levodopa; Macrocyclic Compounds; Male; Microdialysis; Oxazoles; Potassium; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ruthenium Red; Ryanodine; Ryanodine Receptor Calcium Release Channel; Time Factors; Verapamil | 2004 |
Fertilization and inositol 1,4,5-trisphosphate (IP3)-induced calcium release in type-1 inositol 1,4,5-trisphosphate receptor down-regulated bovine eggs.
Topics: Adenosine; Animals; Biological Clocks; Calcium; Calcium Channel Agonists; Calcium Channels; Cattle; Cell Cycle; Down-Regulation; Female; Fertilization; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Mice; Oocytes; Receptors, Cytoplasmic and Nuclear; Sperm-Ovum Interactions; Swine | 2005 |
Postsynaptic IP3 receptor-mediated Ca2+ release modulates synaptic transmission in hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine; Age Factors; Animals; Animals, Newborn; Bicuculline; Blotting, Western; Calcium; Calcium Channel Agonists; Calcium Channels; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation, Developmental; Hippocampus; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Neurons; Patch-Clamp Techniques; Picrotoxin; Rats; Receptors, Cytoplasmic and Nuclear; Synaptic Transmission; Thapsigargin; Time Factors | 2005 |
Inositol 1,4,5-trisphosphate receptor 1 degradation in mouse eggs and impact on [Ca2+]i oscillations.
Topics: Adenosine; Animals; Calcium Signaling; Down-Regulation; Female; Fertilization; Humans; Injections; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Mice; Ovum; Protein Processing, Post-Translational; Time Factors | 2010 |
Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.
Topics: Adenosine; Animals; Fluorescein-5-isothiocyanate; Fluorescence Polarization; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Protein Binding; Rats; Thermodynamics | 2010 |
Selective determinants of inositol 1,4,5-trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5-trisphosphate receptors.
Topics: Adenosine; Animals; Calcium; Calcium Channel Agonists; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Male; Mutation; Protein Binding; Rats; Rats, Wistar | 2010 |
IP3-mediated octopamine-induced synaptic enhancement of crayfish LG neurons.
Topics: Adenosine; Animals; Astacoidea; Electric Stimulation; Enzyme Inhibitors; Estrenes; Female; Ganglia, Invertebrate; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Interneurons; Male; Octopamine; Pyrrolidinones; Sensation; Sensory Thresholds; Serotonin; Synaptic Potentials; Synaptic Transmission; Time Factors; Type C Phospholipases | 2012 |
Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues.
Topics: Adenosine; Amino Acid Sequence; Animals; Calcium; Cell Line; Hydroxides; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Models, Molecular; Molecular Sequence Data; Phosphates; Protein Conformation; Structure-Activity Relationship | 2013 |
Focal activation of cells by plasmon resonance assisted optical injection of signaling molecules.
Topics: Adenosine; Calcium; Cell Line; Cell Line, Tumor; Female; Gap Junctions; Gold; Humans; Inositol 1,4,5-Trisphosphate; Liposomes; Metal Nanoparticles; Nanotechnology; Optics and Photonics; Ovarian Neoplasms; Signal Transduction; Surface Plasmon Resonance | 2014 |
Highly Sensitive Measurement of Inositol 1,4,5-Trisphosphate by Using a New Fluorescent Ligand and Ligand Binding Domain Combination.
Topics: Adenosine; Animals; Binding Sites; Chlorocebus aethiops; COS Cells; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Inositol 1,4,5-Trisphosphate; Ligands; Molecular Structure | 2016 |
Bcl-2 and IP
Topics: Adenosine; Amino Acid Sequence; Animals; Binding, Competitive; Calcium Signaling; Cells, Cultured; Chlorocebus aethiops; COS Cells; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Ligands; Mice; Molecular Docking Simulation; Protein Domains; Proto-Oncogene Proteins c-bcl-2; Sequence Deletion | 2019 |