adenine has been researched along with triazoles in 78 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (14.10) | 18.7374 |
| 1990's | 2 (2.56) | 18.2507 |
| 2000's | 20 (25.64) | 29.6817 |
| 2010's | 39 (50.00) | 24.3611 |
| 2020's | 6 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Hodgson, DJ; Purnell, LG; Shepherd, JC | 1 |
| Hirafuji, M; Shinoda, H | 1 |
| Srinivasan, V; Wigfield, DC | 1 |
| Boguslawski, J; Klopotowski, T; Walczak, W | 1 |
| Bagdasarian, G; Hulanicka, D; Klopotowski, T | 1 |
| Klopotowski, T; Rybicka, H | 1 |
| Ershikova, IuE; Pekhov, AP; Stoliarova, LG | 1 |
| Iakovleva, LA; Kulaev, IS; Mel'gunov, VI | 1 |
| Blair, DG; Cross, DC; Peesker, SJ | 1 |
| Schirrmacher, V; Schneider, F | 1 |
| Bagdasarian, G; Klopotowski, T | 1 |
| Casselton, PJ | 1 |
| Dale, TJ; Dupere, JR; Starkey, SJ; Xie, X | 1 |
| Crum, AV; Meno, JR; Winn, HR | 1 |
| Fredholm, BB; Schulte, G | 1 |
| Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC | 1 |
| McClellan, MB | 1 |
| Boehm, S; Freissmuth, M; Just, H; Klinger, M; Korkhov, VM; Kudlacek, O; Nanoff, C; Pankevych, H; Vartian, N; Yang, Q | 1 |
| Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO | 1 |
| Holý, A; Kmonícková, E; Potmesil, P; Zídek, Z | 1 |
| Holý, A; Kmonícková, E; Krecmerová, M; Potmesil, P; Zídek, Z | 1 |
| Huxley, VH; Wang, J | 1 |
| Borsini, F; Carminati, P; Di Cesare, MA; Ghirardi, O; Minetti, P; Stasi, MA; Varani, K; Vincenzi, F | 1 |
| Carminati, P; Jackson, MJ; Jenner, P; Johnson, L; Rose, S; Smith, LA; Stockwell, K | 1 |
| Jenner, P; Ramsay Croft, N; Rose, S | 1 |
| Borsini, F; Carminati, P; Frau, L; Morelli, M; Schintu, N; Simola, N; Tronci, E | 1 |
| Borsini, F; Morelli, M; Pinna, A; Pontis, S | 1 |
| Belcastro, V; Borsini, F; Calabresi, P; Centonze, D; Costa, C; Picconi, B; Tantucci, M; Tozzi, A; Tscherter, A | 1 |
| Böhme, D; Düpre, N; Megger, DA; Müller, J | 1 |
| Borsini, F; Galluzzo, M; Grieco, R; Pèzzola, A; Pintor, A; Popoli, P | 1 |
| Abel, S; Muirhead, GJ; Ridgway, CE; Russell, D; Whitlock, LA | 1 |
| Autuori, A; Belcastro, V; Borsini, F; Calabresi, P; Costa, C; Di Filippo, M; Luchetti, E; Picconi, B; Siliquini, S; Tantucci, M; Tozzi, A | 1 |
| Pinna, A | 1 |
| Cristalli, G; Morelli, M; Pinna, A; Pontis, S; Schintu, N; Simola, N; Tronci, E; Volpini, R | 1 |
| Bartoccini, F; Cabri, W; Celona, D; Minetti, P; Piersanti, G; Tarzia, G | 1 |
| Borsini, F; Frau, L; Khairnar, AS; Morelli, M; Schintu, N; Wardas, J | 1 |
| Curto, J; Niubo, J; Podzamczer, D; Tiraboschi, JM | 1 |
| Budow, S; Eickmeier, H; He, Y; Jiang, D; Kazimierczuk, Z; Reuter, H; Seela, F | 1 |
| Kaptur, PE; Mertenskoetter, T | 1 |
| Férir, G; Palmer, KE; Schols, D | 1 |
| Chaiken, I; Fletcher, P; Gopi, H; Krebs, FC; Martin-Garcia, J; McFadden, K; Pirrone, V; Rajagopal, S; Rossi, F; Shattock, RJ; Umashankara, M | 1 |
| Biragyn, A; Ferrucci, L; Goetzl, EJ; Hesdorffer, CS; Kennedy, RT; Longo, DL; Mabrouk, OS; Madara, K; Malchinkhuu, E; Schwartz, JB; Taub, DD | 1 |
| Back, DJ; Else, LJ; Khoo, SH; Taylor, S | 1 |
| Caballero, AB; Castillo, Ó; Dobado, JA; Lezama, L; Rodríguez-Diéguez, A; Salas, JM; Vidal, I | 1 |
| Fang, J; Jadhav, PR | 1 |
| Acosta, EP; Barreca, ML; Chirullo, B; Collins, M; Della Corte, A; Greenhouse, J; Iraci, N; Lewis, MG; Norelli, S; Savarino, A; Shytaj, IL; Yalley-Ogunro, J | 1 |
| Castonguay, A; Doucet, C; Juhas, M; Maysinger, D | 1 |
| Strohmeier, M; Vogt, FG | 1 |
| Bag, SS; Kundu, R; Matsumoto, K; Talukdar, S | 1 |
| Craig, C; Fätkenheuer, G; Heera, J; Leal, M; McFadyen, L; Mildvan, D; Mills, A; Podzamczer, D; Portsmouth, S; Rinehart, AR; Than, S; Valdez, H; Valluri, SR; Vourvahis, M | 1 |
| Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J | 1 |
| Bennett, LJ; Grooms-Williams, TW; Hamorsky, KT; Husk, AS; Matoba, N; Palmer, KE | 1 |
| Bartoccini, F; Borsini, F; Cabri, W; Lucarini, S; Minetti, P; Piersanti, G; Riccioni, T; Stasi, MA; Tarzia, G | 1 |
| Chrysikos, D; Dimopoulos, MA; Papadimitriou, CA; Psaltopoulou, T; Sergentanis, TN; Zagouri, F | 1 |
| Feucht, N; Hadeler, J; Lanzl, I; Loos, D; Schmid, RM; Schwerdtfeger, C; Spinner, CD | 1 |
| Binet, L; Djerada, Z; Feliu, C; Gozalo, C; Lamiable, D; Marty, H; Millart, H; Robinet, A; Tournois, C; Vautier, D | 1 |
| Abbasi, NA; Hafiz, IA; Hussain, A; Pervaiz, T; Yaseen, M | 1 |
| Alarcón, M; Caballero, J; Fuentes, E; Palomo, I; Rojas, A | 1 |
| McGowan, I | 1 |
| Dierckx, A; Grøtli, M; Lawson, CP; Miannay, FA; Wellner, E; Wilhelmsson, LM | 1 |
| Achhra, AC; Boyd, MA; Cooper, DA; Kelleher, AD; Law, MG; Matthews, GV | 1 |
| Ceribelli, M; Ferrer, M; Guha, R; Joshi, S; Keller, JM; Kelly, PN; Liu, D; Mathews Griner, LA; Nerle, S; Normant, E; Patel, PR; Sandy, P; Shaffer, AL; Shinn, P; Staudt, LM; Thomas, CJ; Wright, GW; Xiao, W; Yang, Y | 1 |
| Akkina, R; Kashuba, ADM; LeCureux, J; Remling-Mulder, L; Sykes, C; Veselinovic, M; Yang, KH | 1 |
| Cohen, MS; Emerson, CW; Fedoriw, Y; Geller, EJ; Kashuba, AD; Nelson, JA; Nicol, MR; Patterson, KB; Prince, HM; Sykes, C | 1 |
| Beckwith, KA; Byrd, JC; Guinn, D; Hing, ZA; Johnson, AJ; Lapalombella, R; Lehman, AM; Mantel, R; Smith, LL; Williams, E; Williams, K; Woyach, JA | 1 |
| De La Mata, FJ; Gómez, R; Jiménez, JL; Muñoz-Fernández, MÁ; Sánchez-Rodríguez, J; Sepúlveda-Crespo, D; Serramía, MJ | 1 |
| Borsini, F; Caprioli, A; Di Serio, S; Lombardo, K; Minetti, P; Pace, S; Riccioni, T; Stasi, MA; Vertechy, M | 1 |
| Bhalla, KN; Bradner, JE; Coarfa, C; Devaraj, SG; Fiskus, W; Krieger, S; Li, L; Qi, J; Rajapakshe, K; Saenz, DT; Shah, B; Sharma, S; Sun, B; Wang, ML; Zhang, L | 1 |
| Cheng, MP; Cummins, KC; Davids, MS; Issa, NC; Kubiak, DW; Marty, FM | 1 |
| Kadri, S; Landesman, Y; Lee, J; Lu, P; Maltsev, N; Ming, M; Shacham, S; Sharma, S; Sukhanova, M; Wang, W; Wang, YL; Wu, W; Xie, B | 1 |
| Arribas, AJ; Bertoni, F; Cascione, L; Curti, E; Gaudio, E; Priebe, V; Rossi, D; Spriano, F; Stathis, A; Tarantelli, C; Zhang, L; Zucca, E | 1 |
| Choi, CM; Choi, YJ; Hong, JY; Kim, DH; Lee, JC; Rho, JK; Suh, C; Yoon, DH | 1 |
| Bennis, Y; Boone, M; Chouaki, T; Delette, C; Joseph, C; Mabille, C; Maizel, J; Marolleau, JP; Nyga, R | 1 |
| Cao, B; Deng, Y; Jin, G; Wang, X; Wang, Z; Yu, B; Zhou, J | 1 |
| Abrisqueta, P; Bobillo, S; Boix, J; Bosch, F; Carabia, J; Castellví, J; Céspedes Torrez, DH; Crespo, M; Escoda, L; Jiménez, I; Martínez-Ricarte, F; Nieto, JC; Pagès, C; Palacio, C; Perla, C; Puigdefàbregas, L; Purroy, N; Seoane, J | 1 |
| Kittikulsuth, W; Li, L; Morisawa, N; Nakano, D; Nishiyama, A; Ohsaki, H; Suzuki, N; Yamamoto, M; Zhang, A | 1 |
| Andersen, BN; Hansen, LN; Heidtmann, CV; Kelawi, N; Klitgaard, JK; Kongsted, J; Nielsen, CU; Nielsen, P; Nielsen, S; Pedersen, M; Reinholdt, P; Sørensen, SH; Urlund, B; Voukia, F | 1 |
| Baker, S; Bhat, S; Byrd, JC; Canfield, D; Cempre, CB; Fu, Q; Hu, B; Huang, Y; Jaglowski, SM; Lapalombella, R; Lockman, H; Rogers, KA; Ruppert, AS; Shah, H; Stephens, DM; Vadeboncoeur, R; Walker, JS; Woyach, JA | 1 |
5 review(s) available for adenine and triazoles
| Article | Year |
|---|---|
Novel investigational adenosine A2A receptor antagonists for Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Disease Models, Animal; Humans; Parkinson Disease; Pyrimidines; Triazoles | 2009 |
Update on microbicide research and development - seeking new HIV prevention tools for women.
Topics: Adenine; Administration, Intravaginal; Adult; Africa South of the Sahara; Anti-HIV Agents; Anti-Infective Agents; Clinical Trials as Topic; Cyclohexanes; Drug Discovery; Female; HIV Infections; Humans; Male; Maraviroc; Organophosphonates; Pyridines; Pyrimidines; Tenofovir; Triazoles; Urea | 2011 |
Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).
Topics: Adenine; Adult; Amniotic Fluid; Anti-HIV Agents; Cyclohexanes; Enfuvirtide; Female; Fetal Blood; Fetus; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Maraviroc; Nevirapine; Organophosphonates; Peptide Fragments; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Viral Load; Zidovudine | 2011 |
Hsp90 inhibitors in breast cancer: a systematic review.
Topics: Adenine; Antineoplastic Agents; Benzamides; Benzoquinones; Biomarkers, Tumor; Female; Glycine; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Indazoles; Isoxazoles; Lactams, Macrocyclic; Pyridines; Resorcinols; Triazoles; Triple Negative Breast Neoplasms | 2013 |
An overview of antiretroviral pre-exposure prophylaxis of HIV infection.
Topics: Adenine; Anti-HIV Agents; Cyclohexanes; Drug Resistance, Viral; Female; HIV Infections; Humans; Male; Maraviroc; Medication Adherence; Nitriles; Organophosphonates; Pre-Exposure Prophylaxis; Pyridones; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Triazoles | 2014 |
4 trial(s) available for adenine and triazoles
| Article | Year |
|---|---|
The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents; CCR5 Receptor Antagonists; Cyclohexanes; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Maraviroc; Middle Aged; Organophosphonates; Receptors, CCR5; Statistics as Topic; Tenofovir; Triazoles; Trimethoprim, Sulfamethoxazole Drug Combination | 2008 |
From in vitro EC₅₀ to in vivo dose-response for antiretrovirals using an HIV disease model. Part I: a framework.
Topics: Adenine; Anti-HIV Agents; Cyclohexanes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV-1; Humans; Inhibitory Concentration 50; Male; Maraviroc; Models, Biological; Nitriles; Organophosphonates; Oxazines; Piperazines; Pyridazines; Pyridones; Pyrimidines; RNA, Viral; Tenofovir; Triazoles | 2012 |
Maraviroc once-daily nucleoside analog-sparing regimen in treatment-naive patients: randomized, open-label pilot study.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; CCR5 Receptor Antagonists; CD4 Lymphocyte Count; Cyclohexanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Fusion Inhibitors; HIV Infections; HIV-1; Humans; Male; Maraviroc; Middle Aged; Oligopeptides; Organophosphonates; Pilot Projects; Pyridines; Ritonavir; RNA, Viral; Tenofovir; Triazoles; Viral Load; Young Adult | 2013 |
Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study.
Topics: Adenine; Adult; Humans; Hydrazines; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Piperidines; Pyrazoles; Pyrimidines; Triazoles | 2022 |
69 other study(ies) available for adenine and triazoles
| Article | Year |
|---|---|
Interaction of metal ions with 8-azapurines. Synthesis and structure of tetrachlorobis-2-((5-amino-4-carboxamidinium)(1,2,3)triazole)copper(II) monohydrate.
Topics: Adenine; Aza Compounds; Chemical Phenomena; Chemistry; Copper; Triazoles; X-Ray Diffraction | 1975 |
Platelet-leukocyte interaction in adhesion to endothelial cells induced by platelet-activating factor in vitro.
Topics: Adenine; Animals; Azepines; Blood Platelets; Cell Adhesion; Diterpenes; Endothelium, Vascular; Female; Ginkgolides; Humans; In Vitro Techniques; Lactones; Leukocytes; Neutrophils; Platelet Activating Factor; Platelet Adhesiveness; Pregnancy; Rabbits; Thiazoles; Triazoles; Umbilical Veins | 1991 |
Liquid scintillation counting and sample adsorption. Structural factors in organic molecules controlling likelihood of adsorption.
Topics: Acetamides; Acetates; Adenine; Adsorption; Alcohols; Alkanes; Anhydrides; Antipyrine; Azo Compounds; Barbiturates; Benzoates; Benzyl Compounds; Carbamates; Carbon Radioisotopes; Cholesterol; Cinnamates; Cyanides; Dicarboxylic Acids; Ferrocyanides; Glucose; Glutarates; Leucine; Niacinamide; Nitrophenols; Phenoxyacetates; Scintillation Counting; Structure-Activity Relationship; Testosterone; Triazoles | 1974 |
Reversal by serine and potentiation by glycine of the inhibitory effect of 1,2,4-triazole on growth of Salmonella typhimurium.
Topics: Adenine; Amino Acids; Cysteine; Drug Resistance, Microbial; Drug Synergism; Glycine; Homocysteine; Methionine; Mutation; Salmonella typhimurium; Serine; Triazoles | 1967 |
Inhibition of aminoimidazole ribotide biosynthesis in Salmonella typhimurium by aminotriazole.
Topics: Adenine; Hypoxanthines; Imidazoles; Ligases; Lyases; Mutation; Nucleosides; Purines; Ribose; Salmonella typhimurium; Transferases; Triazoles | 1969 |
Purine metabolism in wheat shoots treated with aminotriazole.
Topics: Adenine; Adenine Nucleotides; Amines; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Glycine; Guanine; Histidine; Light; Plants; Polynucleotides; Purines; Radiation Effects; Triazoles | 1972 |
[Isolation of mutant Hela and Am-1 cells resistant to analogs of nitrogenous bases].
Topics: Adenine; Azaguanine; Cell Line; Female; Guanine Nucleotides; HeLa Cells; Humans; Hypoxanthines; Mitosis; Mutation; Nucleosides; Phospholipids; Purines; Pyrimidines; Triazoles | 1970 |
[Effect of 8-azaadenine on the metabolism of phosphorus compounds in Neurospora crassa mutants auxotrophic with respect to adenine].
Topics: Adenine; DNA; Genetics, Microbial; Mutation; Neurospora; Nucleotides; Phosphorus; Pyrimidines; RNA; Triazoles | 1970 |
The toxicity of adenine and of purine-analogs to 2,6-diamino-purine-sensitive and -resistant L-strain mouse cells.
Topics: Adenine; Albumins; Amino Acids; Aminobenzoates; Animals; Culture Media; Hypoxanthines; Imidazoles; L Cells; Mercaptopurine; Mice; Nucleosides; Pantothenic Acid; Purines; Pyrimidines; Thiamine; Thioguanine; Triazoles | 1970 |
[Effect of imidazole derivatives and other 5-membered heterocyclic compounds on adenine phosphoribosyltransferase].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Glucosyltransferases; Imidazoles; Kinetics; Neoplasm Proteins; RNA, Neoplasm; Triazoles | 1967 |
Partial reversal by purine and pyrimidine bases of yeast growth inhibition produced by 3-amino-1,2,4-triazole.
Topics: Adenine; Cytosine; Drug Resistance, Microbial; Histidine; Hydro-Lyases; Mutation; Purines; Pyrimidines; Saccharomyces; Triazoles | 1966 |
Influence of the nitrogen source on the adenine reversal of 3-amino-1,2,4-triazole inhibition of Prototheca zopfii growth.
Topics: Adenine; Eukaryota; Glutamates; Quaternary Ammonium Compounds; Triazoles | 1967 |
The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.
Topics: Action Potentials; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Anticonvulsants; Brain Chemistry; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; Triazoles | 1999 |
Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation.
Topics: Adenine; Administration, Topical; Animals; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials, Somatosensory; Injections, Intraperitoneal; Male; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2001 |
Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Benzophenanthridines; CHO Cells; Cricetinae; Cyclic AMP Response Element-Binding Protein; Cytoplasm; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Male; Mice; Mitogen-Activated Protein Kinases; Phenanthridines; Phosphorylation; Protein Kinase C; Purinergic P1 Receptor Antagonists; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; Triazoles; Xanthines | 2002 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Female; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Triazoles; Xanthines | 2002 |
From the Food and Drug Administration.
Topics: Adenine; Anastrozole; Antineoplastic Agents, Hormonal; Antiviral Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Hepatitis B, Chronic; Humans; Nitriles; Organophosphonates; Triazoles; United States; United States Food and Drug Administration | 2002 |
The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclases; Animals; Benzamides; Binding, Competitive; Cell Cycle; Cell Membrane; Cofilin 1; Colforsin; Cyclic AMP; Cytoskeletal Proteins; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Enzyme Activation; Gene Expression; Glutamic Acid; Humans; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pertussis Toxin; Phenethylamines; Phosphodiesterase Inhibitors; Phosphoproteins; Propionates; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyrrolidines; Quinpirole; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Purinergic P1; Thionucleotides; Transfection; Triazines; Triazoles; Xenopus Proteins | 2003 |
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles | 2005 |
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
Topics: Adenine; Animals; Caffeine; Cell Survival; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Female; Gene Expression; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles | 2006 |
Adenosine A2A receptor modulation of juvenile female rat skeletal muscle microvessel permeability.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aging; Animals; Arterioles; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gene Expression Regulation; Muscle, Skeletal; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Receptor, Adenosine A2A; Receptor, Adenosine A2B; RNA, Messenger; Serum Albumin; Triazines; Triazoles; Vasodilator Agents; Venules | 2006 |
ST 1535: a preferential A2A adenosine receptor antagonist.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Catalepsy; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Male; Mice; Motor Activity; Radioligand Assay; Time Factors; Transfection; Triazoles; Tritium; Xanthines | 2006 |
The novel adenosine A2a receptor antagonist ST1535 potentiates the effects of a threshold dose of L-DOPA in MPTP treated common marmosets.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Antiparkinson Agents; Callithrix; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Dyskinesia, Drug-Induced; Female; Levodopa; Male; Motor Activity; Motor Skills; MPTP Poisoning; Triazoles | 2006 |
The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of l-dopa in unilaterally 6-OHDA-lesioned rats.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Brain; Disease Models, Animal; Dopamine Agents; Dose-Response Relationship, Drug; Drug Synergism; Exploratory Behavior; Levodopa; Male; Movement; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Receptor, Adenosine A2A; Sympatholytics; Triazoles | 2007 |
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Adrenergic Agents; Animals; Antiparkinson Agents; Behavior, Animal; Corpus Striatum; Dynorphins; Enkephalins; Glutamate Decarboxylase; Isoenzymes; Levodopa; Male; Oxidopamine; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tacrine; Tremor; Triazoles | 2007 |
Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Dihydroxyphenylalanine; Dopamine Agents; Functional Laterality; Immunohistochemistry; Levodopa; Male; Neuroprotective Agents; Parkinson Disease; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Triazoles; Tyrosine 3-Monooxygenase; Vibrissae | 2007 |
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.
Topics: Adenine; Adenosine; Animals; Cerebral Cortex; Corpus Striatum; Dopamine Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Phenethylamines; Quinpirole; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Dopamine D2; Synaptic Transmission; Triazines; Triazoles | 2007 |
Conformational change induced by metal-ion-binding to DNA containing the artificial 1,2,4-triazole nucleoside.
Topics: Adenine; DNA; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Nucleosides; Oligonucleotides; Silver; Temperature; Thymine; Triazoles | 2007 |
Behavioural and neurochemical characterization of the adenosine A2A receptor antagonist ST1535.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Wistar; Triazoles | 2008 |
A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity.
Topics: Action Potentials; Adenine; Adenosine A2 Receptor Antagonists; Animals; Cerebral Cortex; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Insecticides; Male; Neurons; Rats; Rats, Wistar; Rotenone; Time Factors; Triazines; Triazoles | 2009 |
A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Brain Chemistry; CD11b Antigen; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Early Growth Response Protein 1; Gene Expression Regulation; Jaw; Levodopa; Male; Mice; Mice, Inbred C57BL; Motor Activity; Movement; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Psychomotor Performance; Pyrimidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rotarod Performance Test; Time Factors; Triazoles; Vibrissae | 2010 |
Direct B-alkyl Suzuki-Miyaura cross-coupling of 2-halopurines. Practical synthesis of ST1535, a potent adenosine A2A receptor antagonist.
Topics: Adenine; Magnetic Resonance Spectroscopy; Purines; Receptor, Adenosine A2A; Triazoles | 2010 |
Neuroprotective and anti-inflammatory effects of the adenosine A(2A) receptor antagonist ST1535 in a MPTP mouse model of Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Anti-Inflammatory Agents; Brain; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neuroprotective Agents; Parkinsonian Disorders; Triazoles | 2011 |
Maraviroc concentrations in cerebrospinal fluid in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; CCR5 Receptor Antagonists; CD4 Lymphocyte Count; Chromatography, Liquid; Cyclohexanes; Didanosine; HIV Fusion Inhibitors; HIV Infections; HIV-1; Humans; Male; Maraviroc; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Tandem Mass Spectrometry; Tenofovir; Triazoles; Viral Load | 2010 |
7-Amino-1-(2-deoxy-β-erythro-pentofuranosyl)-1H-1,2,3-triazolo[4,5-d]pyrimidine: an 8-azaadenine nucleoside with the nucleobase in a syn conformation.
Topics: Adenine; Base Sequence; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Pyrimidine Nucleosides; Pyrimidines; Triazoles | 2010 |
Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C.
Topics: Adenine; Algal Proteins; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclohexanes; Drug Synergism; Enfuvirtide; Genotype; HIV Envelope Protein gp41; HIV-1; Humans; Lectins; Leukocytes, Mononuclear; Maraviroc; Microbial Sensitivity Tests; Organophosphonates; Peptide Fragments; Plant Lectins; Tenofovir; Triazoles | 2011 |
Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors.
Topics: Adenine; Anti-HIV Agents; Cell Line; Drug Therapy, Combination; HIV Envelope Protein gp120; HIV Fusion Inhibitors; HIV-1; Humans; Organophosphonates; Peptides; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Virus Replication | 2012 |
Distinctive immunoregulatory effects of adenosine on T cells of older humans.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Antigens, CD; Apyrase; CD28 Antigens; Cells, Cultured; Chemotaxis; Cytokines; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Male; Middle Aged; Phenethylamines; Pyrimidines; T-Lymphocytes; Triazoles; Young Adult | 2012 |
Insights on the binding ability of a new adenine analog: 7-amine-1,2,4-triazolo[1,5-a]pyrimidine. Synthesis and magnetic study of the first copper(II) complexes.
Topics: Adenine; Coordination Complexes; Copper; Electron Spin Resonance Spectroscopy; Ligands; Models, Molecular; Pyrimidines; Triazoles | 2012 |
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.
Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cyclohexanes; Darunavir; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Flow Cytometry; Fluorescent Antibody Technique; Macaca mulatta; Maraviroc; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Simian Acquired Immunodeficiency Syndrome; Sulfonamides; T-Lymphocyte Subsets; Tenofovir; Triazoles; Viral Load; Viremia | 2012 |
New ruthenium(II)-letrozole complexes as anticancer therapeutics.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Aromatase Inhibitors; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Curcumin; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Letrozole; Nitriles; Ruthenium; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2012 |
2D solid-state NMR analysis of inclusion in drug-cyclodextrin complexes.
Topics: Adenine; Carbon Radioisotopes; Cyclodextrins; Diflunisal; Fluorine Radioisotopes; Hydrogen; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Phosphorus; Pyrimidines; Triazoles; Voriconazole | 2012 |
Triazolyl donor/acceptor chromophore decorated unnatural nucleosides and oligonucleotides with duplex stability comparable to that of a natural adenine/thymine pair.
Topics: Adenine; Base Pairing; Click Chemistry; DNA; Fluorescence; Magnetic Resonance Spectroscopy; Nucleosides; Oligonucleotides; Thymine; Triazoles | 2013 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines | 2013 |
Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana benthamiana plants and utility of VRC01 in combination microbicides.
Topics: Adenine; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antiviral Agents; Chromatography, Affinity; Cyclohexanes; Drug Combinations; Drug Synergism; Genetic Vectors; HIV Antibodies; HIV Envelope Protein gp120; HIV-1; Humans; Immunoglobulin G; Maraviroc; Neutralization Tests; Nicotiana; Organophosphonates; Plant Lectins; Recombinant Proteins; Tenofovir; Tobamovirus; Triazoles | 2013 |
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.
Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Behavior, Animal; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; HEK293 Cells; Humans; Mice; Models, Chemical; Molecular Structure; Parkinson Disease; Radioligand Assay; Receptor, Adenosine A2A; Time Factors; Triazoles | 2013 |
[Ophthalmological alterations at the initial diagnosis of HIV infection].
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Cyclohexanes; Deoxycytidine; Drug Therapy, Combination; Early Diagnosis; Emtricitabine; Eye Infections, Viral; HIV Infections; Humans; Lopinavir; Male; Maraviroc; Organophosphonates; Retinal Diseases; Syndrome; Tenofovir; Treatment Outcome; Triazoles; Zidovudine | 2014 |
Validation of a fast method for quantitative analysis of elvitegravir, raltegravir, maraviroc, etravirine, tenofovir, boceprevir and 10 other antiretroviral agents in human plasma samples with a new UPLC-MS/MS technology.
Topics: Adenine; Anti-Retroviral Agents; Chromatography, High Pressure Liquid; Cyclohexanes; Humans; Maraviroc; Mass Spectrometry; Nitriles; Organophosphonates; Proline; Pyridazines; Pyrimidines; Pyrrolidinones; Quinolones; Raltegravir Potassium; Tandem Mass Spectrometry; Tenofovir; Time Factors; Triazoles | 2013 |
Assessing the response of indigenous loquat cultivar Mardan to phytohormones for in vitro shoot proliferation and rooting.
Topics: Adenine; Benzyl Compounds; Disinfectants; Eriobotrya; Indoles; Kinetin; Mercuric Chloride; Naphthaleneacetic Acids; Plant Growth Regulators; Plant Leaves; Plant Roots; Plant Shoots; Purines; Sodium Hypochlorite; Triazoles | 2013 |
Chlorogenic acid inhibits human platelet activation and thrombus formation.
Topics: Adenine; Adenosine Triphosphate; Animals; Binding Sites; Bleeding Time; Cell Communication; Cell Line; Cell Survival; Chlorogenic Acid; Collagen; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Hemorheology; Humans; Inflammation Mediators; Leukocytes; Mice; Models, Molecular; P-Selectin; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Receptor, Adenosine A2A; Thrombosis; Triazines; Triazoles | 2014 |
Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues.
Topics: Adenine; DNA; Fluorescent Dyes; Molecular Structure; Quantum Theory; Spectrometry, Fluorescence; Triazoles | 2014 |
Moving away from Ritonavir, Abacavir, Tenofovir, and Efavirenz (RATE)--agents that concern prescribers and patients: a feasibility study and call for a trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials as Topic; Cyclohexanes; Cyclopropanes; Dideoxynucleosides; Feasibility Studies; Female; Humans; Male; Maraviroc; Middle Aged; Organophosphonates; Ritonavir; Tenofovir; Triazoles | 2014 |
Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors.
Topics: Adenine; Animals; Azepines; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Survival; Drug Synergism; Humans; I-kappa B Kinase; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, SCID; Nuclear Proteins; Piperidines; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Pyrazoles; Pyrimidines; Signal Transduction; Transcription Factors; Triazoles; Xenograft Model Antitumor Assays | 2014 |
HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model.
Topics: Adenine; Animals; Anti-HIV Agents; Cyclohexanes; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Maraviroc; Mice; Mucous Membrane; Organophosphonates; Pre-Exposure Prophylaxis; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Virus Internalization | 2014 |
Models for predicting effective HIV chemoprevention in women.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Cell Culture Techniques; Cell Survival; Chemoprevention; Chromatography, Liquid; Cyclohexanes; Disease Transmission, Infectious; Dose-Response Relationship, Drug; Female; HIV Infections; Humans; Maraviroc; Middle Aged; Organ Culture Techniques; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Triazoles; Vagina; Viral Load; Young Adult | 2015 |
Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrazines; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Piperidines; Pyrazoles; Pyrimidines; Triazoles; Xenograft Model Antitumor Assays | 2015 |
Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission.
Topics: Adenine; Animals; Anti-HIV Agents; Anti-Infective Agents; Antiviral Agents; Cell Survival; Cyclohexanes; Dendrimers; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Maraviroc; Mice; Mice, Inbred BALB C; Mucous Membrane; Organophosphonates; Silanes; Software; Tenofovir; Triazoles; Vagina | 2015 |
Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535).
Topics: Adenine; Adenosine A2 Receptor Antagonists; Administration, Oral; Animals; Antiparkinson Agents; Basal Ganglia; Binding, Competitive; Catalepsy; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; HEK293 Cells; Humans; Injections, Intraperitoneal; Ligands; Male; Mice; Motor Activity; Oxidopamine; Parkinsonian Disorders; Protein Binding; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Transfection; Triazoles | 2015 |
Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Azepines; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Lymphoma, Mantle-Cell; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Nuclear Proteins; Piperidines; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyrazoles; Pyrimidines; Transcription Factor RelA; Transcription Factors; Triazoles | 2015 |
Isavuconazole for the treatment of invasive fungal disease in patients receiving ibrutinib.
Topics: Adenine; Antifungal Agents; Humans; Invasive Fungal Infections; Nitriles; Piperidines; Pyrazoles; Pyridines; Pyrimidines; Treatment Outcome; Triazoles | 2019 |
XPO1 Inhibitor Selinexor Overcomes Intrinsic Ibrutinib Resistance in Mantle Cell Lymphoma via Nuclear Retention of IκB.
Topics: Adenine; Apoptosis; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Exportin 1 Protein; Humans; Hydrazines; I-kappa B Proteins; Karyopherins; Lymphoma, Mantle-Cell; NF-kappa B; Piperidines; Protein Subunits; Pyrazoles; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Triazoles | 2018 |
The Bruton tyrosine kinase inhibitor zanubrutinib (BGB-3111) demonstrated synergies with other anti-lymphoma targeted agents.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Combined Chemotherapy Protocols; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Drug Synergism; Humans; Hydrazines; Lymphoma, B-Cell; Lymphoma, Mantle-Cell; Niacinamide; Piperidines; Pyrazoles; Pyrimidines; Sulfonamides; Triazoles; Tumor Cells, Cultured | 2019 |
Efficacy of the novel CDK7 inhibitor QS1189 in mantle cell lymphoma.
Topics: Adenine; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lymphoma, Mantle-Cell; Phosphorylation; Piperidines; Pyrazoles; Pyrimidines; RNA Polymerase II; Sulfonamides; Triazoles | 2019 |
Ibrutinib related cerebral aspergillosis successfully treated with isavuconazole: a case report.
Topics: Adenine; Antifungal Agents; Aspergillosis; Humans; Nitriles; Piperidines; Pyridines; Triazoles | 2020 |
A chemical conjugation of JQ-1 and a TLR7 agonist induces tumoricidal effects in a murine model of melanoma via enhanced immunomodulation.
Topics: Adenine; Animals; Azepines; B7-H1 Antigen; Cytokines; Drug Synergism; Immunomodulation; Lymphocytes, Tumor-Infiltrating; Melanoma, Experimental; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Succinates; T-Lymphocytes, Cytotoxic; Toll-Like Receptor 7; Triazoles | 2021 |
Repolarization of tumor infiltrating macrophages and increased survival in mouse primary CNS lymphomas after XPO1 and BTK inhibition.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Central Nervous System Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Exportin 1 Protein; Female; Humans; Hydrazines; Karyopherins; Lymphoma, Non-Hodgkin; Macrophages; Mice; Mice, Nude; Piperidines; Receptors, Cytoplasmic and Nuclear; Survival Rate; Triazoles; Tumor Cells, Cultured; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice.
Topics: Acute Kidney Injury; Adenine; Anemia; Animals; Disease Models, Animal; Erythropoietin; Hypoxia-Inducible Factor 1; Male; Mice, Inbred C57BL; Prolyl-Hydroxylase Inhibitors; Pyrazoles; Triazoles | 2020 |
Discovery of a Potent Adenine-Benzyltriazolo-Pleuromutilin Conjugate with Pronounced Antibacterial Activity against MRSA.
Topics: Adenine; Animals; Anti-Bacterial Agents; Binding Sites; Catalysis; Cell Line; Cell Survival; Copper; Cycloaddition Reaction; Diterpenes; Dogs; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Pleuromutilins; Polycyclic Compounds; Structure-Activity Relationship; Triazoles | 2020 |