adenine has been researched along with sirolimus in 221 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.45) | 18.2507 |
| 2000's | 18 (8.14) | 29.6817 |
| 2010's | 176 (79.64) | 24.3611 |
| 2020's | 26 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Blommaart, EF; Blommaart, PJ; Luiken, JJ; Meijer, AJ; van Woerkom, GM | 1 |
| Abbondandolo, A; Bonatti, S; Pigullo, S; Simili, M | 1 |
| Backer, JM; Brachmann, SM; Cooper, J; Eskelinen, EL; Lucocq, JM; Prescott, AR; Tang, X; Wang, L | 1 |
| Beugnet, A; Proud, CG; Taylor, PM; Tee, AR | 1 |
| Fujita, E; Isoai, A; Kaufman, RJ; Kominami, E; Kouroku, Y; Kumagai, H; Momoi, T; Ogawa, S; Tanida, I; Ueno, T | 1 |
| Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W | 1 |
| Berka, U; Blaas, D; Brabec-Zaruba, M; Fuchs, R | 1 |
| Dunn, SR; Schnitzler, CE; Weis, VM | 1 |
| Archange, C; Gonzalez, CD; Grasso, D; Iovanna, JL; Lo Re, A; Nowak, J; Pardo, R; Ropolo, A; Sacchetti, ML; Seux, M; Vaccaro, MI | 1 |
| Niu, H; Rikihisa, Y; Yamaguchi, M | 1 |
| Zeng, M; Zhou, JN | 1 |
| Bae, D; Lu, S; Mercurio, AM; Taglienti, CA | 1 |
| Fujiwara, H; Fujiwara, T; Goto, K; Horie, T; Kanamori, H; Maruyama, R; Minatoguchi, S; Miyata, S; Nagao, K; Nagashima, K; Ono, K; Takemura, G; Tsujimoto, A; Ushikoshi, H | 1 |
| Balduini, W; Buonocore, G; Carloni, S | 1 |
| Ambrosio, S; Francisco, R; Giménez-Xavier, P; Pérez, R; Platini, F | 1 |
| Lei, HY; Wang, YH; Wu, JJ | 1 |
| Ahn, J; Choi, JE; Ha, YE; Kim, DH; Lee, H; Yoon, SY | 1 |
| Benavides, A; Frost, P; Hoang, B; Lichtenstein, A; Shi, Y | 1 |
| Chai, Y; Hu, H; Kim, SH; Lee, HJ; Lü, J; Wang, L; Zhang, J | 1 |
| Kobayashi, S; Liang, Q; Mao, K; Timm, D; Volden, P; Xu, X | 1 |
| Tan, KSW; Ye, AJJ; Yin, J | 1 |
| Dong, J; Huang, Q; Lou, M; Qin, Z; Wang, A; Yang, J; Zhang, T; Zhao, Y | 1 |
| Chai, L; Cheng, M; Ren, Y; Wang, S; Xie, Y | 1 |
| Chrysanthopoulou, A; Kambas, K; Kourtzelis, I; Mitroulis, I; Rafail, S; Ritis, K; Speletas, M | 1 |
| Gao, B; Han, R; Liu, XQ; Qin, ZH; Sheng, R; Zhang, LS | 1 |
| Amarnath, S; Costanzo, CM; Eckhaus, M; Flomerfelt, FA; Foley, JE; Fowler, DH; Gangopadhyay, A; June, CH; Konecki, DM; Levine, BL; Mariotti, J; Wong, S | 1 |
| Choi, CH; Jung, YK; Oh, SH | 1 |
| Ikejima, T; Li, L; Liu, B; Onodera, S; Tashiro, S; Yang, P; Ye, Y; Zhou, Y | 1 |
| Hwang, KC; Kim, NH; Lee, SE; Sun, SC; Xu, YN | 1 |
| Briant, L; Denizot, M; Gasque, P; Gay, B; Hoarau, JJ; Jaffar-Bandjee, MC; Krejbich-Trotot, P; Li-Pat-Yuen, G | 1 |
| Ji, WJ; Liang, ZQ; Long, LM; Zhuang, WZ | 1 |
| Deguchi, T; Doki, Y; Eguchi, H; Ito, T; Kobayashi, S; Machida, T; Marubashi, S; Mori, M; Nagano, H; Ohmura, Y; Tanemura, M; Tsukamoto, R; Wada, H | 1 |
| Balduini, W; Buonocore, G; Carloni, S; Longini, M; Proietti, F | 1 |
| Ghosh, D; Roepe, PD; Sinai, AP; Walton, JL | 1 |
| Gao, B; Han, R; Liu, XQ; Qin, ZH; Sheng, R; Wu, YQ; Zhang, LS; Zhang, XY | 1 |
| Biagioni, F; Fabrizi, C; Fornai, F; Fumagalli, L; Lenzi, P; Pompili, E; Somma, F | 1 |
| Chen, K; Kobayashi, S; Liang, Q; Xu, X | 1 |
| Chen, G; Jing, CH; Liu, PP; Ruan, D; Wang, L; Wu, C | 1 |
| Hao, HP; Hu, XC; Huang, L; Ishag, HA; Li, C; Li, PP; Mao, X; Sun, MX; Wang, R; Yu, YL | 1 |
| Feuer, R; Gottlieb, RA; Sayen, MR; Tabor-Godwin, JM; Tsueng, G | 1 |
| Cui, XS; Heo, YT; Kim, DJ; Kim, NH; Kwon, JS; Lee, SE; Shen, XH; Xu, YN | 1 |
| Carp, RI; Choi, EK; Kim, YS; Oh, JM | 1 |
| D'Alessio, A; Facchiano, A; Filippini, A; Giampietri, C; Marini, ES; Padula, F; Petrungaro, S; Ziparo, E | 1 |
| Araújo, AP; Cyrino, LT; Giorgio, S; Joazeiro, PP; Vicente, CP | 1 |
| Cui, G; Gao, L; Gu, L; Guo, J; Jiang, T; Liu, Y; Su, L; Zhang, Y | 1 |
| Anderson, C; Buss, LW; Kritzberger, C; Lakkis, FG; Moreno, MA; Poudyal, M; Westerman, E | 1 |
| Lei, FR; Li, XQ; Liu, H; Meng, QY; Rong, JJ; Zhu, RD | 1 |
| Moad, AI; Muhammad, TS; Oon, CE; Tan, ML | 1 |
| Koh, HC; Lee, JE; Park, JH; Shin, IC | 1 |
| Chen, L; Fu, JX; Gao, LS; Zhang, H; Zhang, XH; Zhang, YY | 1 |
| Chen, X; Ding, G; Ma, T; Singhal, PC; Zha, D; Zhu, J | 1 |
| Fang, R; Fang, Y; He, Y; Huang, L; Xue, Z; Zhang, S | 1 |
| Buchan, AM; Chen, R; Drakesmith, CW; Hadley, G; Hoyte, LC; Kessler, B; McMenamin, MM; Nagel, S; Papadakis, M; Tsaknakis, G; Vekrellis, K; Watt, SM; Wood, MJ; Xilouri, M; Zhao, Z | 1 |
| Hou, J; Huang, H; Liu, X; Tang, H; Wang, C; Wang, M; Wang, Y; Weng, J; Zhang, R | 1 |
| Amarnath, S; Dropulic, B; Felizardo, TC; Foley, J; Fowler, DH; Medin, JA; Steed, K | 1 |
| Chen, J; Chen, S; Li, YQ; Lin, YM; Qing, Y; Wang, M; Wu, D | 1 |
| Abais, JM; Boini, KM; Chen, Y; Li, PL; Li, X; Riebling, CR; Wei, YM; Xu, M; Zhang, Y | 1 |
| Aligny, C; Bekri, S; Brasse-Lagnel, C; Genty, D; Gonzalez, BJ; Laquerrière, A; Lesueur, C; Marret, S; Roux, C | 1 |
| Li, W; Liu, JG; Qi, XK; Qian, HR; Xia, DY; Yao, S | 1 |
| Choi, YJ; Lee, BH; Lee, K; Lee, KY; Oh, S; Oh, SH; Yang, MJ; Yang, YS | 1 |
| Bruserud, Ø; Hatfield, KJ; Nepstad, I; Reikvam, H | 1 |
| Hu, HY; Kuo, SH; Lee, YR; Lei, HY; Lin, YS; Liu, CC; Liu, HS; Yeh, TM | 1 |
| Cecconi, F; Ciarlo, L; D'Amelio, M; Malorni, W; Marinelli, S; Nazio, F; Pavone, F; Pieroni, L; Tinari, A; Urbani, A; Vacca, V | 1 |
| Bincoletto, C; Hirata, H; Pereira, GJ; Smaili, SS; Tressoldi, N | 1 |
| Chang, J; Hu, Y; Wang, M; Wang, W; Yin, Z; Zhang, H | 1 |
| Hirano, A; Kitaoka, Y; Kojima, K; Munemasa, Y; Takagi, H; Ueno, S | 1 |
| Chen, JY; Chen, WJ; Chu, LW; Huang, LY; Huang, YL; Lee, CH; Lee, JH; Lin, YH; Ping, YH; Xiang, R | 1 |
| Chen, J; Dong, X; Gou, H; Liao, M; Liu, W; Luo, Y; Pei, J; Wang, J; Ye, Z; Yi, L; Zhao, M | 1 |
| Cederbaum, AI; Wu, D | 1 |
| Cheng, CC; Chiu, TH; Huang, YT; Lai, PC; Lin, TC | 1 |
| Choi, D; Choi, J; Jo, M; Kim, HJ; Lee, E | 1 |
| Choi, EJ; Kee, SH | 1 |
| Duan, QH; Li, J; Lu, QP; Lu, T; Luo, P; Tang, ZZ; Wang, ZQ; Wu, JP; Yang, Y | 1 |
| Chang, HC; Chang, SC; Chiang, CK; Chou, CT; Chuang, YT; Ho, IL; Hsu, CH; Huang, KH; Kuo, KL; Lee, PY; Lin, WC; Liu, SH; Pu, YS | 1 |
| Chang, J; Cheng, L; Ji, D; Li, J; Liu, R; Liu, X; Sun, Z; Wang, C; Wang, S; Wang, X; Zhang, X; Zhang, Z; Zheng, B; Zheng, R | 1 |
| Gao, M; Jiang, B; Jiang, Y; Li, Y; Liu, Y; Lu, Q; Tong, Z; Xiao, X; Yao, Y; Zhang, L | 1 |
| Huang, J; Li, Q; Sun, X; Wang, H; Zhang, T | 1 |
| Cai, L; Cui, S; Kan, G; Lin, L; Sun, W; Tang, Q; Xu, C; Yu, C; Zhao, S | 1 |
| Cai, JP; Jiang, P; Lan, Y; Li, J; Liu, DG; Liu, J; Luo, J; Pang, JX; Ren, YL; Wang, C | 1 |
| Lin, JH; Liu, WG; Muharram, A; Wang, ZY | 1 |
| Gu, WD; Huang, J; Jiang, RY; Pei, HL; Wang, ZG | 1 |
| Chen, D; Deng, X; Ding, W; Long, F; Rui, W; Wang, L; Zhang, F; Zhao, Y | 1 |
| Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS | 1 |
| Duan, R; Gao, H; Jia, Y; Li, Y; Peng, T; Teng, J; Wang, C; Wang, X; Zhang, G | 1 |
| Chakrabarti, M; Cockrell, AL; Lindahl, PA; McCormick, SP; Park, J | 1 |
| Darley Usmar, VM; Dodson, M; Giordano, S; Ouyang, X; Ravi, S; Redmann, M; Zhang, J | 1 |
| Li, X; Su, J; Wang, K; Zhang, T; Zhu, T | 1 |
| Chang, JM; Chen, CA; Chen, HC; Cheng, YC | 1 |
| Cao, L; Chuai, M; Lee, KK; Li, S; Li, Y; Lu, WH; Song, XY; Wang, G; Wang, XY; Yang, X | 1 |
| Liu, S; Liu, X; Liu, Z; Niu, Z; Sun, L; Wang, H; Xie, F | 1 |
| Castillo, JJ; Ghobrial, IM; Treon, SP | 1 |
| Ji, W; Panus, D; Wang, C; Zhong, X | 1 |
| Xian, R; Yang, Z; Yuan, B; Zhong, L; Zhong, S | 1 |
| Bie, M; Cui, Q; Lv, Y; Ren, C; So, KF; Xiao, J; Xing, F | 1 |
| Gao, N; Li, Z; Wang, H; Yang, Z; Zhang, T | 1 |
| Cui, LY; Yang, S; Zhang, J; Zhang, YL | 1 |
| Li, G; Li, M; Li, Z; Liu, P; Liu, Y; Liu, Z; Ma, L; Shao, W; Sui, D; Wang, B | 1 |
| Dai, H; Du, Y; Guan, X; Qian, J; Qian, Y; Shen, Y; Yan, Y; Zhang, L | 1 |
| Treon, SP | 1 |
| Cai, GQ; Chen, XD; Gu, W; Peng, JP; Shen, C | 1 |
| Bayerl, S; Dreyling, M; Hiddemann, W; Hutter, G; Zimmermann, Y; Zoellner, AK | 1 |
| Du, Y; Hao, H; Li, Y; Liu, H; Lv, T; Wang, J; Wang, L; Wang, X; Zhang, S; Zuo, L | 1 |
| Chen, Y; Gao, F; Lu, B; Shi, G; Wang, B; Xu, H; Zhang, Y; Zheng, F; Zhong, S | 1 |
| Atarashi, R; Fuse, T; Homma, T; Ishibashi, D; Nakagaki, T; Nishida, N; Sano, K; Takatsuki, H | 1 |
| Chen, H; Ling, H; Meng, X; Wei, M; Xie, K; Yu, Y | 1 |
| Cederbaum, AI; Lu, Y | 1 |
| Du, J; Li, J; Liu, J; Liu, X; Wang, R; Wang, W; Wang, X; Yang, Q; Zhu, J | 1 |
| Balasubramanian, S; Bandyopadhyay, N; Bence-Bruckler, I; Bothos, J; Caballero, D; Cho, SG; Dreyling, M; Enny, C; Goldberg, JD; Hess, G; Jerkeman, M; Joao, C; Jurczak, W; Offner, F; Rizo, A; Rule, S; Rusconi, C; Silva, RS; Sun, S; Traina, S; Trneny, M; Vermeulen, J; Witzens-Harig, M | 1 |
| Martin, P | 1 |
| Chai, J; Chen, D; Guo, H; Kou, B; Shi, Y; Yan, X; Zhu, Z | 1 |
| Huang, K; Liu, D | 1 |
| Barton, LA; Chen, Y; Fuller, ND; Guo, R; Henion, JM; Hu, N; Pang, J; Ren, J | 1 |
| Chen, S; Dai, H; Deng, Z; Du, H; Hei, TK; Liu, Y; Nie, Y; Wang, J; Wang, M; Wang, X; Wu, L; Xu, A | 1 |
| Duan, J; Liu, Q; Mu, H; Niu, H; Tang, J; Wang, D | 1 |
| Fang, Y; Guo, Y; Xue, Z | 1 |
| Chen, D; Hu, X; Hua, Q; Li, X; Lin, J; Liu, Y; Pan, C; Tan, F; Wan, Y; Zheng, L | 1 |
| Cen, S; Chen, Z; Deng, H; Hou, J; Li, J; Li, W; Liu, Z; Ouyang, Y; Shen, H; Song, B; Wang, P; Wu, Y; Xie, Z; Yang, R | 1 |
| Clarke, JP; Mearow, K | 1 |
| Bao, NR; Chen, FS; Fang, B; Li, XQ; Ma, H; Pi, XL; Tan, WF; Zhang, Y | 1 |
| Cao, L; Chuai, M; Liu, L; Lu, WH; Ma, ZL; Münsterberg, A; Shi, YX; Song, X; Wang, G; Yang, X | 1 |
| Chen, RM; Chen, TL; Hsieh, MH; Lin, CJ; Lin, YW; Tseng, YY; Wu, GJ | 1 |
| Chen, XX; Huang, H; Liu, SS; Wang, LL; Wang, XR; Wang, XW; Wei, XM; Wu, JX | 1 |
| Li, Z; Yang, Z; Yin, H; Zhang, T; Zhang, X | 1 |
| Chen, L; Li, Z; Wan, Q; Xin, W; Xu, Y; Yu, Y; Zhou, Q | 1 |
| Cheng, Z; Lin, M; Liu, H; Niu, H; Rikihisa, Y; Xiong, Q; Yamamoto, A | 1 |
| Chen, L; Fan, T; Geng, Q; Hu, H; Huang, Z; Mao, Z; Pan, S; Wang, W; Xu, Y; Zhang, B | 2 |
| Bi, J; Gao, F; He, W; Huang, H; Lan, Y; Song, D; Wang, G; Zhang, D; Zhao, K | 1 |
| Castro, PF; Chiong, M; Lavandero, S; Martínez, GJ; Pizarro, M; Troncoso, R | 1 |
| Chen, M; Peng, HY; Sha, LL; Wang, C; Wang, H; Zhao, MH | 1 |
| Fu, X; Guo, Y; Lin, C; Wu, S; Xia, W; Xu, P; Yao, M | 1 |
| Fei, Y; Fu, X; Li, B; Li, W; Meng, X; Wei, X; Wu, Z; Zeng, M; Zheng, Y | 1 |
| Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS | 1 |
| Feng, X; Guo, L; Hou, H; Zou, Y | 1 |
| Chen, JT; Chen, RM; Cheng, BC; Chio, CC; Liu, SH; Yang, ST | 1 |
| Chen, L; Fan, T; Geng, Q; Hu, H; Huang, Z; Mao, Z; Wang, W; Xu, Y; Zhang, B | 1 |
| Bai, Y; Cao, Z; Dong, S; Dou, C; Fei, J; Liu, C; Liu, X; Wang, Y | 1 |
| Chen, S; Chen, Y; Lai, B; Liang, H; Liu, J; Song, L; Tang, H; Xu, L; Yang, H; Yun, L; Zhou, K | 1 |
| Li, J; Mu, Y; Yan, WJ; Yang, J; Yin, TL; Zhang, Y | 1 |
| Ding, N; Gao, F; He, W; Lan, Y; Li, Z; Lu, H; Lv, X; Su, J; Zhao, K | 1 |
| Ji, C; Jia, H; Qian, H; Wang, B; Wang, J; Xu, W; Yan, Y; Yin, L; Yu, J; Zhang, B; Zhu, X | 1 |
| Gao, LP; Jing, YH; Lv, DD; Qi, CC; Song, YF; Wang, DG; Yin, J; Zhang, L | 1 |
| Bissoyi, A; Kashyap, MP; Patra, PK; Rizvi, SI; Singh, AK | 1 |
| Bence-Bruckler, I; Caballero, D; Chiou, CF; Cho, SG; Diels, J; Dreyling, M; Enny, C; Goldberg, JD; Hess, G; Jerkeman, M; Joao, C; Jurczak, W; Rule, S; Rusconi, C; Santucci Silva, R; Traina, S; Trambitas, C; Vermeulen, J; Witzens-Harig, M; Zhou, W | 1 |
| Qiu, W; Sun, Y; Wang, P; Zhang, D; Zhang, F; Zhang, P | 1 |
| Huang, S; Huang, W; Huang, Z; Jia, Z; Lin, L; Zhu, Z | 1 |
| Guan, H; Han, X; Jin, F; Li, X; Qin, J; Shan, M; Wang, Y; Zhang, H; Zhang, J | 1 |
| Bai, Y; Jiang, L; Liu, N; Liu, X; Sun, X; Wang, S; Wu, X; Yang, G; Yao, X; Zhai, X | 1 |
| Casini, G; Clemente, N; De Cillà, S; Farruggio, S; Filippini, D; Gatti, V; Grossini, E; Mary, D; Raina, G; Rossetti, L; Vezzola, D; Vujosevic, S | 1 |
| Ding, L; Hu, T; Jiang, W; Jin, Z; Qiu, C; Sun, Z; Wang, Y; Yang, J; Yang, M; Zhang, N; Zhang, S; Zhang, Z | 1 |
| Chai, R; Ding, X; Fang, Q; Gao, X; Guo, L; He, Z; Kong, W; Li, H; Liu, D; Liu, Y; Lu, L; Sha, S; Shu, Y; Tang, M; Zhang, X; Zhou, H | 1 |
| Deng, JB; Deng, JX; Fu, S; Li, YQ; Liu, B; Shi, ZY; Wang, L; Wang, Q | 1 |
| Hu, LK; Sun, YL; Wang, HJ; Zhao, T; Zhao, WW | 1 |
| Hou, Q; Jia, MM; Jiang, Y; Lu, YQ; Qiu, T; Wang, BH; Wang, XH; Zhang, ZX | 1 |
| Ding, DF; Dong, CL; Lu, YB; Ma, JH; Pan, ML; Xu, XH; Ye, XL; Yong, HJ; You, N; You, Q | 1 |
| Cao, T; Chen, C; Fang, W; Gu, Y; Li, X; Shan, Y; Shi, X; Xin, Y; Zhou, Y | 1 |
| Deng, Y; Liu, C; Liu, W; Ma, Z; Tan, X; Wang, C; Xu, B; Xu, ZF; Yan, DY; Yang, TY | 1 |
| Boido, M; De Amicis, E; Garcera, A; Guglielmotto, M; Piras, A; Puyal, J; Schiaffino, L; Soler, RM; Tamagno, E; Valsecchi, V; Vercelli, A | 1 |
| Dai, P; Li, C; Li, Y; Li, Z; Zhou, X | 1 |
| Beckelman, BC; Galli, LD; Kasica, NP; Ma, T; Ryazanov, AG; Yang, W; Zhou, X; Zimmermann, HR | 1 |
| Liang, Q; Liu, Y; Zhang, S | 1 |
| Chen, SH; Huang, KJ; Kuo, CH; Lee, YR; Lin, CY | 1 |
| Gong, J; He, Q; Jin, J; Shen, W; Ye, M; Zhang, H; Zhao, L; Zou, W | 1 |
| Chu, BX; Fan, RF; Lin, SQ; Wang, L; Wang, ZY; Yang, DB | 1 |
| Bence-Bruckler, I; Caballero, D; Cho, SG; Dreyling, M; Goldberg, J; Henninger, T; Hess, G; Jerkeman, M; Joao, C; Jurczak, W; Offner, F; Rule, S; Rusconi, C; Thieblemont, C; Trneny, M; Vermeulen, J; Witzens-Harig, M; Zhou, W | 1 |
| Hsu, TI; Jou, IM; Ko, PY; Kuo, YL; Su, FC; Tu, YK; Yang, CC | 1 |
| Fang, M; Fei, X; Gong, F; Hua, S; Li, L; Li, Q; Qi, C; Zhang, Y | 1 |
| Cheng, W; Duan, SB; Lei, R; Li, XW; Luo, M; Tang, CY; Yang, SK; Zhao, F | 1 |
| Niu, G; Wang, J; Wang, X; Zhang, X; Zhao, Y; Zhu, D | 1 |
| An, W; Cao, S; Lai, H; Li, X; Lin, X; Liu, M; Zhang, D; Zhao, G | 1 |
| Barr, PM; Burger, JA; Chang, S; Coutre, S; Cramer, P; Dilhuydy, MS; Fraser, G; Graef, T; Hess, G; Hillmen, P; Howes, A; James, DF; Liu, E; Moreno, C; O'Brien, S; Patel, K; Styles, L; Tedeschi, A; Valentino, R; Vermeulen, J | 1 |
| Campos, CBL; Góes, CG; Morais, FV; Onorio, DS; Ribeiro, GF | 1 |
| Chen, D; Chen, Z; Dai, C; Han, Z; He, F; Li, Y; Tan, R; Tian, H; Wang, G; Wang, M; Wei, L; Yang, B; Yang, H; Zhang, B | 1 |
| Chen, J; Min, S; Wang, X; Xie, F; Yang, J | 1 |
| Chen, FP; Feng, G; Fu, YF; Liu, X; Mu, GF; Wang, X; Xiong, D | 1 |
| Huang, X; Jiang, B; Li, Y; Liang, P; Liu, Z; Xiao, X; Zhang, M; Zhang, P | 1 |
| Liu, T; Yang, JW; Zhang, QH | 1 |
| Chen, D; Chen, Y; Duan, Z; Ji, J; Ren, F; Shi, H; Xu, P; Yue, X; Zhang, Y | 1 |
| Chen, X; Gan, F; Huang, K; Liu, D; Pan, C; Qian, G; Sun, Y; Xu, J; Xu, S | 1 |
| Cheng, E; Cheng, Y; Olden, BR; Pun, SH | 1 |
| Diao, C; Du, Y; Liu, H; Liu, X; Wang, L | 1 |
| Chen, SB; Ling, X; Liu, S; Liu, WC; Tang, J; Xu, QR; Yu, BT | 1 |
| Abuzeid, AMI; Hu, J; Li, G; Li, J; Liao, S; Lin, X; Lv, M; Qi, N; Sun, M; Wu, C; Xiao, W; Yu, L | 1 |
| An, J; Jiang, P; Li, Y; Shen, Y; Wang, M; Zhang, J; Zhou, N | 1 |
| Dong, A; Duan, Q; Tao, K; Yang, W; Zhu, X | 1 |
| Li, B; Li, Y; Lin, L; Luo, Y; Niu, L; Yao, X | 1 |
| Hisatsune, A; Katsuki, H; Kurauchi, Y; Oshima, M; Seki, T | 1 |
| Fan, H; Guo, X; Kong, Y; Liu, L; Zhang, H; Zhang, Q; Zhou, Y | 1 |
| Alizadeh, S; Meshkani, R; Sadeghi, A; Shabani, M | 1 |
| Chen, F; Chen, Y; Dai, B; Hu, W; Qian, X; Song, S; Wang, K; Wu, X; Zhou, R; Zhu, C; Zhu, F | 1 |
| Chen, Y; Luo, C; Zhou, Q; Zhu, C | 1 |
| Funahashi, H; Kohata-Ono, C; Wakai, T | 1 |
| Abhyankar, S; Kabadi, SM; Signorovitch, J; Song, J; Telford, C; Yao, Z; Zhao, J | 1 |
| Cao, H; Chen, C; Jia, Q; Shen, D; Xing, S; Yan, L | 1 |
| Hou, JM; Li, N; Wu, HJ; Xue, Y; Zhang, Y; Zhang, ZN; Zhao, LJ | 1 |
| Feng, Z; Kang, Y; Li, Y; Wen, H; Zheng, J; Zhu, J | 1 |
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3 review(s) available for adenine and sirolimus
| Article | Year |
|---|---|
Biology, prognosis, and therapy of Waldenström Macroglobulinemia.
Topics: Adenine; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Boronic Acids; Bortezomib; Everolimus; Humans; Piperidines; Prognosis; Proteasome Inhibitors; Pyrazines; Pyrazoles; Pyrimidines; Salvage Therapy; Sirolimus; Stem Cell Transplantation; Waldenstrom Macroglobulinemia | 2015 |
Matching-adjusted Indirect Comparisons of the Efficacy and Safety of Acalabrutinib Versus Other Targeted Therapies in Relapsed/Refractory Mantle Cell Lymphoma.
Topics: Adenine; Antineoplastic Agents; Benzamides; Bortezomib; Humans; Lenalidomide; Lymphoma, Mantle-Cell; Neoplasm Recurrence, Local; Piperidines; Pyrazines; Pyrazoles; Pyrimidines; Rituximab; Sirolimus; Treatment Outcome | 2019 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
6 trial(s) available for adenine and sirolimus
| Article | Year |
|---|---|
Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study.
Topics: Adenine; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Kaplan-Meier Estimate; Lymphoma, Mantle-Cell; Male; Middle Aged; Neoplasm Staging; Piperidines; Pyrazoles; Pyrimidines; Recurrence; Sirolimus; Treatment Outcome | 2016 |
Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance, Neoplasm; Female; Humans; Lymphoma, Mantle-Cell; Male; Middle Aged; Neoplasm Staging; Piperidines; Pyrazoles; Pyrimidines; Quality of Life; Retreatment; Sirolimus; Treatment Outcome | 2017 |
Ibrutinib versus temsirolimus: 3-year follow-up of patients with previously treated mantle cell lymphoma from the phase 3, international, randomized, open-label RAY study.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Follow-Up Studies; Humans; International Agencies; Lymphoma, Mantle-Cell; Piperidines; Prognosis; Pyrazoles; Pyrimidines; Salvage Therapy; Sirolimus; Survival Rate | 2018 |
Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Female; Follow-Up Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Male; Middle Aged; Patient Safety; Piperidines; Prognosis; Pyrazoles; Pyrimidines; Rituximab; Sirolimus; Survival Rate | 2018 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; 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Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Molecular determinants of outcomes in relapsed or refractory mantle cell lymphoma treated with ibrutinib or temsirolimus in the MCL3001 (RAY) trial.
Topics: 3' Untranslated Regions; Adenine; Adult; Biological Factors; Humans; Lymphoma, Mantle-Cell; Neoplasm Recurrence, Local; Piperidines; Pyrazoles; Pyrimidines; Sirolimus | 2022 |
213 other study(ies) available for adenine and sirolimus
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes.
Topics: Adenine; Animals; Autophagy; Male; Phosphorylation; Polyenes; Proteins; Rats; Rats, Wistar; Ribosomal Protein S6; Ribosomal Proteins; Ribosomes; Sirolimus | 1995 |
Induction of apoptosis and inhibition of signalling pathways by alkylated purines.
Topics: Adenine; Alkylation; Androstadienes; Animals; Antibiotics, Antineoplastic; Apoptosis; Cell Line; Cricetinae; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Inhibitors; Fibroblasts; G1 Phase; Genes, p53; Guanine; MAP Kinase Signaling System; Mutation; Phosphorylation; Purines; Resting Phase, Cell Cycle; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Inhibition of autophagy in mitotic animal cells.
Topics: Adenine; Anaphase; Androstadienes; Animals; Autophagy; Blotting, Western; Cell Line; Chromones; Endoplasmic Reticulum; Enzyme Inhibitors; Golgi Apparatus; HeLa Cells; Humans; Immunohistochemistry; Metaphase; Microscopy, Immunoelectron; Microscopy, Phase-Contrast; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Telophase; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2002 |
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.
Topics: Adenine; Amino Acids; Animals; Anisomycin; Blotting, Western; Carrier Proteins; CHO Cells; Cricetinae; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation; Immunosuppressive Agents; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2003 |
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Caspase 12; Cell Death; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Leucine; Lysosomes; Mice; Microtubule-Associated Proteins; Models, Biological; Pepstatins; Peptides; Phosphorylation; Protein Structure, Quaternary; RNA, Messenger; Sirolimus | 2007 |
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Induction of autophagy does not affect human rhinovirus type 2 production.
Topics: Adenine; Autophagy; Cells, Cultured; Humans; Microtubule-Associated Proteins; Phagosomes; Rhinovirus; Sirolimus; Tamoxifen; Virus Replication | 2007 |
Apoptosis and autophagy as mechanisms of dinoflagellate symbiont release during cnidarian bleaching: every which way you lose.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Autophagy; Dinoflagellida; Dose-Response Relationship, Drug; Hot Temperature; RNA Interference; Sea Anemones; Sirolimus; Symbiosis; Wortmannin | 2007 |
The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; HeLa Cells; Humans; Membrane Proteins; Mice; Microtubule-Associated Proteins; Neoplasms; Neurodegenerative Diseases; NIH 3T3 Cells; Pancreatitis, Acute Necrotizing; Phagosomes; Protein Binding; Proteins; RNA, Small Interfering; Sirolimus | 2007 |
Subversion of cellular autophagy by Anaplasma phagocytophilum.
Topics: Adenine; Anaplasma phagocytophilum; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line; Haplorhini; Humans; Inclusion Bodies; Intracellular Membranes; Lipid Bilayers; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Sirolimus | 2008 |
Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carrier Proteins; Cell Differentiation; Cell Line, Tumor; Cell Size; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Mice; Morpholines; Neurites; Neuroblastoma; Neurons; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tretinoin | 2008 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia; Lysosomes; Macrolides; Neuropilin-1; Neuropilin-2; Sirolimus | 2008 |
Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Cell Shape; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Leupeptins; Male; Microtubule-Associated Proteins; Myocytes, Cardiac; Necrosis; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Sirolimus; Time Factors; Vacuoles | 2008 |
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury.
Topics: Adenine; Analysis of Variance; Androstadienes; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Count; Cerebral Cortex; Hippocampus; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Simvastatin; Sirolimus; Wortmannin | 2008 |
LC3-I conversion to LC3-II does not necessarily result in complete autophagy.
Topics: Adenine; Autophagy; Blotting, Western; Dopamine; Humans; Microscopy, Electron; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neuroblastoma; Phosphatidylinositol 3-Kinases; Protein Kinases; Serum; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2008 |
The autophagic induction in Helicobacter pylori-infected macrophage.
Topics: Adenine; Animals; Autophagy; Bacterial Proteins; Cell Line; Cell Proliferation; Helicobacter Infections; Helicobacter pylori; Humans; Macrophages; Mice; Microbial Viability; Microtubule-Associated Proteins; Monocytes; Mutation; Sirolimus; Vacuoles | 2009 |
Autophagy in coxsackievirus-infected neurons.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autophagy; Calpain; Caspases; Coxsackievirus Infections; Cysteine Proteinase Inhibitors; Models, Biological; Neurons; Rats; Sirolimus; Virus Replication | 2009 |
Effect of autophagy on multiple myeloma cell viability.
Topics: Adenine; Antifungal Agents; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Cell Proliferation; Chloroquine; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Immunoblotting; Membrane Proteins; Microscopy, Fluorescence; Multiple Myeloma; Pyrazines; RNA, Small Interfering; Sirolimus; Thapsigargin; Tumor Cells, Cultured | 2009 |
Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; Gene Knockdown Techniques; GTPase-Activating Proteins; Humans; Hydrolyzable Tannins; Male; Membrane Proteins; Mice; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Protein Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sirolimus; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay | 2009 |
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Doxorubicin; GATA4 Transcription Factor; Gene Expression Regulation; Gene Knockdown Techniques; Microtubule-Associated Proteins; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sirolimus | 2010 |
Autophagy is involved in starvation response and cell death in Blastocystis.
Topics: Adenine; Androstadienes; Autophagy; Blastocystis; Microscopy, Confocal; Microscopy, Electron, Transmission; Sirolimus; Vacuoles; Wortmannin | 2010 |
Autophagy impairment inhibits differentiation of glioma stem/progenitor cells.
Topics: Adenine; Autophagy; Blotting, Western; Cadaverine; Cell Differentiation; Cells, Cultured; Central Nervous System Agents; Glioma; Humans; Immunohistochemistry; Macrolides; Microscopy, Electron, Transmission; Neurons; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus; Stem Cells; Transduction, Genetic | 2010 |
Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells.
Topics: Adenine; Antibiotics, Antineoplastic; Apoptosis; Arsenic Trioxide; Arsenicals; Autophagy; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Leukemia, Promyelocytic, Acute; Oxides; Sirolimus | 2011 |
Regulation of the autophagic machinery in human neutrophils.
Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hydrogen-Ion Concentration; Inflammation; Microscopy, Confocal; Morpholines; Neutrophils; Phagosomes; Poly I-C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sirolimus; Small Ubiquitin-Related Modifier Proteins; Tetradecanoylphorbol Acetate; Toll-Like Receptors; Transcription, Genetic; Vacuoles | 2010 |
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models, Animal; Down-Regulation; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Ischemic Preconditioning; Male; Microtubule-Associated Proteins; Neostriatum; Neurogenesis; Neurons; Neuroprotective Agents; Phagosomes; Rats; Rats, Sprague-Dawley; Sequestosome-1 Protein; Sirolimus; Up-Regulation | 2010 |
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Differentiation; Cell Polarity; Drug Resistance; Gene Knockdown Techniques; Graft vs Host Disease; Humans; Immunologic Memory; Interferon-alpha; Interleukin-12; Lipopolysaccharides; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Transgenic; Phenotype; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Sirolimus; STAT Transcription Factors; T-Lymphocytes, Cytotoxic; Th1 Cells; Tumor Necrosis Factor-alpha | 2010 |
Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines.
Topics: Adenine; Amitrole; Apoptosis; Autophagy; Capsaicin; Catalase; Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Humans; Lung; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA, Small Interfering; Sirolimus | 2010 |
Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; MAP Kinase Kinase 1; NF-kappa B; Nitroprusside; Oncogene Protein p21(ras); PC12 Cells; Phosphatidylinositol 3-Kinases; raf Kinases; Rats; Reactive Oxygen Species; Silybin; Silymarin; Sirolimus | 2011 |
Modulation of autophagy influences development and apoptosis in mouse embryos developing in vitro.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blastocyst; Cell Nucleus; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Histocytochemistry; Male; Mice; Mice, Inbred ICR; Microscopy, Confocal; Mitochondria; Morula; Octamer Transcription Factor-3; Sirolimus | 2011 |
Chikungunya triggers an autophagic process which promotes viral replication.
Topics: Adenine; Alphavirus Infections; Antimetabolites; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Chikungunya Fever; Chikungunya virus; Disease Outbreaks; Europe; Gene Silencing; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunosuppressive Agents; Indian Ocean; Membrane Proteins; Microscopy, Electron; Microscopy, Fluorescence; Phagosomes; Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Sirolimus; Virus Replication | 2011 |
Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Female; Glial Fibrillary Acidic Protein; Glioma; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplastic Stem Cells; RNA, Messenger; Sirolimus; Xenograft Model Antitumor Assays | 2011 |
Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Green Fluorescent Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Transgenic; Microscopy, Fluorescence; Sirolimus; Up-Regulation | 2012 |
Inhibition of rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation.
Topics: Adenine; Animals; Autophagy; bcl-2-Associated X Protein; Caspase 3; Cell Death; Mitochondria; Necrosis; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus | 2012 |
Autophagy is a cell death mechanism in Toxoplasma gondii.
Topics: Adenine; Amino Acids; Animals; Autophagy; Cell Survival; Chlorocebus aethiops; Culture Media; Energy Metabolism; Host-Parasite Interactions; Humans; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Prokaryotic Initiation Factor-2; Protein Biosynthesis; Signal Transduction; Sirolimus; Stress, Physiological; Toxoplasma; Vero Cells | 2012 |
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 12; Caspase 3; Cells, Cultured; Cerebral Cortex; Cinnamates; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucose; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Ischemic Preconditioning; Male; Mice; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Sirolimus; Thiourea; Transcription Factor CHOP | 2012 |
Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures.
Topics: Adenine; Adjuvants, Immunologic; Aldehydes; Analysis of Variance; Animals; Asparagine; Autophagy; Brain; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; L-Lactate Dehydrogenase; Lithium Chloride; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphorylation; Serine; Sirolimus; Tetrazolium Salts; Thiazoles; Trimethyltin Compounds; Vacuoles | 2012 |
Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury.
Topics: Adenine; Animals; Animals, Newborn; Autophagy; Autophagy-Related Protein 7; Cardiotonic Agents; Cell Death; Cell Survival; Cytoprotection; Ether-A-Go-Go Potassium Channels; Gene Knockdown Techniques; Glucose; Humans; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Myocytes, Cardiac; Phagosomes; Phosphorylation; Proteins; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin-Activating Enzymes | 2012 |
Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Disease Models, Animal; In Situ Nick-End Labeling; Male; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitochondria; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sirolimus; Subarachnoid Hemorrhage | 2012 |
Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Survival; Endocytosis; Gene Knockdown Techniques; Lysosomes; Membrane Fusion; Microtubule-Associated Proteins; Phagosomes; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; RNA Interference; Sirolimus; Swine; Viral Nonstructural Proteins; Virus Replication | 2012 |
The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.
Topics: Adenine; Adenosine; Animals; Autophagy; Cell Differentiation; Coxsackievirus Infections; Enterovirus B, Human; Fibroblast Growth Factors; Green Fluorescent Proteins; HeLa Cells; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sirolimus; Transduction, Genetic; Viral Load; Viral Proteins; Virus Replication | 2012 |
Autophagy influences maternal mRNA degradation and apoptosis in porcine parthenotes developing in vitro.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blastocyst; Cell Cycle Proteins; Ectogenesis; Female; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Meiosis; Microtubule-Associated Proteins; Oocytes; Parthenogenesis; RNA Stability; RNA, Messenger, Stored; Sirolimus; Sus scrofa; Transcription Factors | 2012 |
Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspases; Enzyme Activation; Gene Knockdown Techniques; Hippocampus; Hydrogen Peroxide; Mice; Models, Biological; Neurons; Oxidative Stress; Prions; Protective Agents; Sirolimus; Time Factors; Trehalose | 2012 |
Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis.
Topics: Adenine; Apoptosis; Autophagy; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Epithelial Cells; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Male; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sirolimus; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2012 |
In vivo and in vitro Leishmania amazonensis infection induces autophagy in macrophages.
Topics: Adenine; Amines; Animals; Autophagy; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microtubule-Associated Proteins; Sirolimus; Staining and Labeling | 2012 |
Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Brain Ischemia; Immunosuppressive Agents; Ischemic Postconditioning; Male; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sirolimus; Up-Regulation | 2012 |
Allorecognition triggers autophagy and subsequent necrosis in the cnidarian Hydractinia symbiolongicarpus.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cnidaria; In Situ Nick-End Labeling; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Biological; Necrosis; Sirolimus | 2012 |
Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Cycle; Cell Proliferation; Cells, Cultured; Rats; Sirolimus | 2012 |
Rapamycin induces apoptosis when autophagy is inhibited in T-47D mammary cells and both processes are regulated by Phlda1.
Topics: Adenine; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Humans; Oligonucleotide Array Sequence Analysis; Sirolimus; Transcription Factors; Up-Regulation | 2013 |
Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival; Chlorpyrifos; Humans; Insecticides; Microtubule-Associated Proteins; Neurotoxicity Syndromes; Proto-Oncogene Proteins c-bcl-2; Sequestosome-1 Protein; Sirolimus; Up-Regulation | 2013 |
[The influence of induced autophagy in vitro on proliferation of multiple myeloma cells].
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Multiple Myeloma; Sirolimus | 2012 |
High glucose induces autophagy in podocytes.
Topics: Acetylcysteine; Adenine; Animals; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blood Glucose; Catalase; Culture Media; Diabetes Mellitus, Experimental; Glucose; Male; Microscopy, Electron; Microtubule-Associated Proteins; Podocytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Streptozocin; Superoxide Dismutase; Tumor Cells, Cultured | 2013 |
Increased expression of Beclin-1-dependent autophagy protects against beta-amyloid-induced cell injury in PC12 cells [corrected].
Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Neurons; PC12 Cells; Peptide Fragments; Phosphopyruvate Hydratase; Rats; Sirolimus; Up-Regulation | 2013 |
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.
Topics: Adenine; Animals; Autophagy; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cells, Cultured; Hypoxia; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neuroprotective Agents; Prosencephalon; Proteins; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2013 |
Decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma.
Topics: Adenine; Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Humans; Male; Membrane Proteins; Microtubule-Associated Proteins; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Phagosomes; Sirolimus; Tongue Neoplasms | 2013 |
Harnessing autophagy for cell fate control gene therapy.
Topics: Adenine; Animals; Antigens, CD19; Apoptosis; Autophagy; CD4-Positive T-Lymphocytes; Cell Lineage; Cell Proliferation; Cell Survival; Genetic Therapy; Humans; Lentivirus; Mice; Nucleoside-Phosphate Kinase; Phenotype; Sirolimus; Transduction, Genetic; Transgenes; Zidovudine | 2013 |
[Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane].
Topics: Adenine; Autophagy; Caco-2 Cells; Glucuronosyltransferase; Humans; Isothiocyanates; Sirolimus; Sulfoxides | 2013 |
Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Calcium-Binding Proteins; Calponins; Cell Proliferation; Cells, Cultured; Coronary Vessels; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lysosomes; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microtubule-Associated Proteins; Muscle Cells; Phenotype; rac1 GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Simvastatin; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Differentiation; Cell Survival; Cell Transplantation; Embryonic Stem Cells; Female; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Interneurons; Male; Mice; Mice, Transgenic; Neocortex; Neural Stem Cells; Pregnancy; Recombinant Fusion Proteins; Sirolimus | 2014 |
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agents; In Situ Nick-End Labeling; Ischemic Preconditioning; Male; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2013 |
Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats.
Topics: Adenine; Administration, Inhalation; Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Autophagy; Autophagy-Related Protein 7; Bronchoalveolar Lavage Fluid; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Gene Knockdown Techniques; Humans; Lung; Macrolides; Male; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; RNA Interference; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transfection; Ubiquitin-Activating Enzymes | 2013 |
Pharmacological targeting of the PI3K/mTOR pathway alters the release of angioregulatory mediators both from primary human acute myeloid leukemia cells and their neighboring stromal cells.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Bone Marrow Cells; Cytogenetics; Cytokines; Female; Humans; Indazoles; Leukemia, Myeloid, Acute; Male; Middle Aged; Molecular Targeted Therapy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Sirolimus; Stromal Cells; Sulfonamides; TOR Serine-Threonine Kinases; Young Adult | 2013 |
Dengue virus infection induces autophagy: an in vivo study.
Topics: Adenine; Animals; Animals, Newborn; Antimetabolites; Autophagy; Blotting, Western; Dengue; Dengue Virus; Fluorescent Antibody Technique; Immunochemistry; Immunosuppressive Agents; Mice; Mice, Inbred ICR; Microscopy, Electron, Transmission; Sirolimus; Viral Load; Virus Replication | 2013 |
Schwann cell autophagy counteracts the onset and chronification of neuropathic pain.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; CD11b Antigen; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immunosuppressive Agents; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Pain Measurement; Schwann Cells; Sciatic Nerve; Sciatica; Sirolimus; Time Factors | 2014 |
Autophagy as a neuroprotective mechanism against 3-nitropropionic acid-induced murine astrocyte cell death.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; bcl-2-Associated X Protein; Beclin-1; Disease Models, Animal; Huntington Disease; Mice; Nitro Compounds; Propionates; Sirolimus | 2013 |
The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.
Topics: Adenine; Aged; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cartilage, Articular; Cell Cycle; Cell Hypoxia; Cell Survival; Cells, Cultured; Chondrocytes; Female; Green Fluorescent Proteins; Humans; Male; Membrane Proteins; Microtubule-Associated Proteins; Middle Aged; Osteoarthritis; Sirolimus; Young Adult | 2013 |
Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.
Topics: Adenine; Animals; Autophagy; Axons; Cell Line; Green Fluorescent Proteins; Heat-Shock Proteins; Intraocular Pressure; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neuroprotective Agents; Nicotinamide-Nucleotide Adenylyltransferase; Optic Nerve; Protein Transport; Rats; Rats, Wistar; Retinal Ganglion Cells; Sequestosome-1 Protein; Sirolimus; Subcellular Fractions; Transfection; Tumor Necrosis Factor-alpha | 2013 |
Single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection.
Topics: Adenine; Autophagy; Cell Line, Tumor; Dengue; Dengue Virus; Host-Pathogen Interactions; Humans; Molecular Imaging; Phagosomes; Sirolimus; Virion | 2014 |
Autophagy enhances the replication of classical swine fever virus in vitro.
Topics: Adenine; Animals; Autophagy; Biomarkers; Cell Line; Cell Survival; Classical Swine Fever; Classical Swine Fever Virus; Intracellular Membranes; Membrane Proteins; Microtubule-Associated Proteins; Phagosomes; RNA, Small Interfering; RNA, Viral; Sirolimus; Swine; Viral Proteins; Virus Replication | 2014 |
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.
Topics: Adenine; Arachidonic Acid; Autophagy; Autophagy-Related Protein 7; Buthionine Sulfoximine; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Hep G2 Cells; Humans; MAP Kinase Signaling System; Mitochondria; Oxidative Stress; Sirolimus; Ubiquitin-Activating Enzymes | 2013 |
Therapeutic potential of sepantronium bromide YM155 in gemcitabine-resistant human urothelial carcinoma cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Deoxycytidine; DNA Fragmentation; Drug Resistance, Neoplasm; Everolimus; Gemcitabine; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Ki-67 Antigen; Microtubule-Associated Proteins; Naphthoquinones; Proto-Oncogene Proteins c-bcl-2; Securin; Sirolimus; Survivin; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms; Urothelium | 2014 |
Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cysts; Endometriosis; Endometrium; Female; Gene Expression Regulation; Humans; Menstrual Cycle; Primary Cell Culture; Sirolimus; Stromal Cells; TOR Serine-Threonine Kinases | 2014 |
Axin expression delays herpes simplex virus-induced autophagy and enhances viral replication in L929 cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Axin Protein; Beclin-1; Cell Line; Gene Expression; Gene Knockdown Techniques; Humans; Membrane Proteins; Simplexvirus; Sirolimus; Virus Replication | 2014 |
Protective effect of autophagy inhibition on ischemia-reperfusion-induced injury of N2a cells.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Survival; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria; Multiprotein Complexes; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reperfusion Injury; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 7; Carcinoma, Transitional Cell; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Macrolides; MAP Kinase Kinase 4; Phosphoproteins; Pyrazoles; RNA, Small Interfering; Signal Transduction; Sirolimus; Sulfonamides; Ubiquitin-Activating Enzymes; Urinary Bladder Neoplasms | 2013 |
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Butadienes; Cell Line, Tumor; Chloroquine; Cyclin D1; Drug Synergism; Everolimus; Flavonoids; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nitriles; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
HSF-1 is involved in attenuating the release of inflammatory cytokines induced by LPS through regulating autophagy.
Topics: Adenine; Animals; Autophagy; Cytokines; DNA-Binding Proteins; Heat Shock Transcription Factors; Immunohistochemistry; Lipopolysaccharides; Mice; Mice, Knockout; Sirolimus; Transcription Factors | 2014 |
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; Benzofurans; Brain Ischemia; Cell Survival; Mice; Neuroblastoma; Sirolimus; Stroke; Tumor Cells, Cultured | 2014 |
High autophagy in the naked mole rat may play a significant role in maintaining good health.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Hepatic Stellate Cells; Immunosuppressive Agents; Longevity; Mice; Microtubule-Associated Proteins; Mole Rats; Sirolimus | 2014 |
Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling.
Topics: Adenine; Animals; Autophagy; Blood Platelets; Cell Adhesion; Cell Membrane; Cytochalasin B; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Male; Rats; Rats, Sprague-Dawley; Sirolimus; Thrombosis | 2014 |
Beclin-1-mediated autophagy protects spinal cord neurons against mechanical injury-induced apoptosis.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Cells, Cultured; Female; Male; Neurons; Rats; Rats, Wistar; Sirolimus; Spinal Cord; Spinal Cord Injuries; TOR Serine-Threonine Kinases | 2014 |
Autophagic inhibitor attenuates rapamycin-induced inhibition of proliferation in cultured A549 lung cancer cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Membrane Proteins; Microtubule-Associated Proteins; Sirolimus | 2014 |
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cell Line, Tumor; Cell Survival; Epithelial Cells; Humans; Lung; Oxidative Stress; Particulate Matter; Reactive Oxygen Species; Signal Transduction; Sirolimus | 2014 |
Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling.
Topics: Adenine; Animals; Autophagy; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Foscarnet; Humans; Hyperphosphatemia; Male; Microtubule-Associated Proteins; Phosphates; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Renal Insufficiency, Chronic; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transfection | 2015 |
Role of autophagy and mTOR signaling in neural differentiation of bone marrow mesenchymal stem cells.
Topics: Adenine; Animals; Autophagy; Bone Marrow Cells; Cell Differentiation; Down-Regulation; Mercaptoethanol; Mesenchymal Stem Cells; Neurogenesis; Rats; Rats, Wistar; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
High-spin ferric ions in Saccharomyces cerevisiae vacuoles are reduced to the ferrous state during adenine-precursor detoxification.
Topics: Adenine; Benzamides; Benzodioxoles; Culture Media; Electron Spin Resonance Spectroscopy; Ferric Compounds; Ferrous Compounds; Hydrogen-Ion Concentration; Iron; Models, Biological; Nonheme Iron Proteins; Saccharomyces cerevisiae; Sirolimus; Spectroscopy, Mossbauer; Vacuoles | 2014 |
Bioenergetic adaptation in response to autophagy regulators during rotenone exposure.
Topics: Adenine; Animals; Autophagy; Cell Survival; Cells, Cultured; Cerebral Cortex; DNA Damage; DNA, Mitochondrial; Dose-Response Relationship, Drug; Embryo, Mammalian; Energy Metabolism; Enzyme Inhibitors; Insecticides; Lactosylceramides; Neurons; Oligomycins; Oxygen Consumption; Rats; Rotenone; Sirolimus | 2014 |
Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cerebral Infarction; Ischemic Postconditioning; Ischemic Preconditioning; Male; Models, Animal; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2014 |
Autophagy modulates endoplasmic reticulum stress-induced cell death in podocytes: a protective role.
Topics: Adenine; Animals; Anti-Bacterial Agents; Apoptosis; Autophagy; Cell Line; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Mice; Models, Animal; Phagosomes; Podocytes; Sirolimus; Thapsigargin; Tunicamycin | 2015 |
Autophagy functions on EMT in gastrulation of avian embryo.
Topics: Adenine; Animals; Autophagy; Cadherins; Cell Adhesion Molecules; Chick Embryo; Epithelial-Mesenchymal Transition; Gastrula; Gastrulation; Gene Expression Regulation, Developmental; Germ Layers; HCT116 Cells; Humans; Microtubule-Associated Proteins; Models, Biological; Sirolimus | 2014 |
Ubenimex inhibits cell proliferation, migration and invasion in renal cell carcinoma: the effect is autophagy-associated.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aminopeptidases; Antibiotics, Antineoplastic; Autophagy; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Leucine; Middle Aged; Neoplasm Invasiveness; Sirolimus; Wound Healing; Young Adult | 2015 |
Modulating polyplex-mediated gene transfection by small-molecule regulators of autophagy.
Topics: Active Transport, Cell Nucleus; Adenine; Animals; Autophagy; Biopharmaceutics; DNA; Gene Expression; Gene Transfer Techniques; Mice; Microscopy, Electron, Transmission; NIH 3T3 Cells; Phagosomes; Polymers; Reactive Oxygen Species; Sirolimus; Transfection | 2015 |
Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model.
Topics: Adenine; Animals; Autophagy; Brain; Cell Hypoxia; Cerebral Arteries; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Microglia; Sirolimus; Stroke; Tumor Necrosis Factor-alpha | 2015 |
Lycium barbarum polysaccharide improves bipolar pulse current-induced microglia cell injury through modulating autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Caspase 7; Cell Line; Drugs, Chinese Herbal; Electric Stimulation; Extracellular Signal-Regulated MAP Kinases; Inflammation; Lycium; Mice; Microglia; Microscopy, Fluorescence; Microtubule-Associated Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Sirolimus; Time-Lapse Imaging | 2015 |
Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cell Shape; Cell Survival; Fluorescent Antibody Technique; Malondialdehyde; Microtubule-Associated Proteins; PC12 Cells; Rats; Reactive Oxygen Species; Sirolimus; Superoxide Dismutase; Triazines | 2016 |
Autophagy activation attenuates renal ischemia-reperfusion injury in rats.
Topics: Acute Kidney Injury; Adenine; Animals; Apoptosis; Autophagy; Blood Urea Nitrogen; Caspase 3; Creatinine; Disease Models, Animal; In Situ Nick-End Labeling; Male; Rats; Rats, Wistar; Reperfusion Injury; Sirolimus | 2015 |
17AAG improves histological and functional outcomes in a rat CCI model through autophagy activation and apoptosis attenuation.
Topics: Adenine; Animals; Apoptosis; Autophagy; Benzoquinones; Brain Edema; Brain Injuries; Cell Survival; Cerebral Cortex; Female; Lactams, Macrocyclic; Motor Skills; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Sirolimus | 2015 |
Autophagy protects renal tubular cells against ischemia / reperfusion injury in a time-dependent manner.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Gene Expression Regulation; Kidney Tubules; Male; Mice; Reperfusion Injury; Sirolimus; Time Factors | 2015 |
How I treat Waldenström macroglobulinemia.
Topics: Adenine; Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Cladribine; Cyclophosphamide; Everolimus; Gene Expression; Genetic Predisposition to Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunoglobulin M; Male; Middle Aged; Molecular Targeted Therapy; Myeloid Differentiation Factor 88; Nitrogen Mustard Compounds; Oligopeptides; Piperidines; Plasmapheresis; Pyrazines; Pyrazoles; Pyrimidines; Receptors, CXCR4; Rituximab; Sirolimus; Transplantation, Autologous; Vidarabine; Waldenstrom Macroglobulinemia | 2015 |
Autophagy protects meniscal cells from glucocorticoids-induced apoptosis via inositol trisphosphate receptor signaling.
Topics: Adenine; Apoptosis; Autophagy; Cells, Cultured; Dexamethasone; Endopeptidases; Extracellular Matrix; Female; Humans; Inositol 1,4,5-Trisphosphate Receptors; Menisci, Tibial; Osteosarcoma; Phosphorylation; RNA, Messenger; Signal Transduction; Sirolimus | 2015 |
Temsirolimus inhibits cell growth in combination with inhibitors of the B-cell receptor pathway.
Topics: Adenine; Antineoplastic Agents; Bortezomib; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Humans; Lymphoma, Large B-Cell, Diffuse; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Purines; Pyrazoles; Pyrimidines; Quinazolinones; Receptors, Antigen, B-Cell; Signal Transduction; Sirolimus | 2015 |
Decreased autophagy: a major factor for cardiomyocyte death induced by β1-adrenoceptor autoantibodies.
Topics: Adenine; Adrenergic beta-1 Receptor Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autoantibodies; Autophagy; Beclin-1; Cardiomyopathies; Cell Line; Gene Expression Regulation; Humans; Immunization, Passive; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Dysfunction, Left; Ventricular Pressure | 2015 |
N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cadaverine; Cell Line; Cytoprotection; Dose-Response Relationship, Drug; Haloperidol; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Microtubule-Associated Proteins; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Rats; RNA Interference; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection | 2015 |
Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells.
Topics: Adenine; Animals; Autophagy; Cell Line; Gerstmann-Straussler-Scheinker Disease; Humans; MAP Kinase Signaling System; Mice; Protein Folding; Proteolysis; PrPSc Proteins; Sirolimus | 2015 |
The Effect of Autophagy on Inflammation Cytokines in Renal Ischemia/Reperfusion Injury.
Topics: Acute Kidney Injury; Adenine; Animals; Anti-Inflammatory Agents; Autophagy; Beclin-1; Enzyme Activation; HMGB1 Protein; Inflammation; Interleukin-10; Interleukin-6; Kidney; Lysosomal-Associated Membrane Protein 2; Male; Microtubule-Associated Proteins; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Tumor Necrosis Factor-alpha | 2016 |
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity.
Topics: Adenine; Animals; Autophagy; Cytochrome P-450 CYP2E1; Ethanol; Liver; Liver Diseases, Alcoholic; Male; Mice; Sirolimus | 2015 |
FoxO3α-mediated autophagy contributes to apoptosis in cardiac microvascular endothelial cells under hypoxia.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Silencing; Male; Microvessels; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sirolimus | 2016 |
Ibrutinib--a new standard treatment for relapsed mantle cell lymphoma?
Topics: Adenine; Antineoplastic Agents; Female; Humans; Lymphoma, Mantle-Cell; Male; Piperidines; Pyrazoles; Pyrimidines; Sirolimus | 2016 |
[Keratin 18 phosphorylation increases autophagy of colorectal cancer HCT116 cells and enhanced its sensitivity to oxaliplatin].
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Colorectal Neoplasms; Flow Cytometry; HCT116 Cells; Humans; Keratin-18; Microscopy, Fluorescence; Mutation; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Serine; Sirolimus; Transfection | 2016 |
Targeting non-canonical autophagy overcomes erlotinib resistance in tongue cancer.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Autophagy-Related Protein 5; Beclin-1; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Hydroxychloroquine; RNA, Small Interfering; Sirolimus; Tongue Neoplasms; Up-Regulation | 2016 |
Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling.
Topics: Adenine; Alcohol Dehydrogenase; Animals; Autophagy; Calcium; Endoplasmic Reticulum Stress; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; Mice, Transgenic; Myocardial Contraction; Myocardium; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Recombinant Fusion Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transgenes; Tunicamycin; Ultrasonography; Ventricular Dysfunction, Left | 2016 |
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.
Topics: Adenine; Androstadienes; Animals; Autophagy; CD59 Antigens; Cell Line; Cricetinae; Graphite; Humans; Hybrid Cells; Mutagens; Oxides; Polychlorinated Biphenyls; Sirolimus; Trehalose; Wortmannin | 2016 |
Autophagy promotes DNA-protein crosslink clearance.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; DNA Damage; Formaldehyde; Gene Silencing; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus; Ubiquitin-Activating Enzymes; Ultraviolet Rays | 2016 |
Moderate activation of autophagy regulates the intracellular calcium ion concentration and mitochondrial membrane potential in beta-amyloid-treated PC12 cells.
Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Calcium; Cell Survival; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; PC12 Cells; Peptide Fragments; Phagosomes; Rats; Sirolimus | 2016 |
Induction of Autophagy interferes the tachyzoite to bradyzoite transformation of Toxoplasma gondii.
Topics: Adenine; Autophagy; Cell Line; Down-Regulation; Fibroblasts; Foreskin; Humans; Male; Organisms, Genetically Modified; Protein Kinase Inhibitors; Sirolimus; Toxoplasma | 2016 |
Autophagy Plays a Protective Role in Tumor Necrosis Factor-α-Induced Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells.
Topics: Adenine; Adult; Apoptosis; Autophagy; Beclin-1; Bone Marrow Cells; Cell Differentiation; Cycloheximide; Female; Humans; Male; Mesenchymal Stem Cells; Multipotent Stem Cells; Phenotype; RNA, Small Interfering; Sirolimus; Tumor Necrosis Factor-alpha | 2016 |
Autophagy inhibition in endogenous and nutrient-deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro.
Topics: Adenine; Animals; Autophagy; Cell Survival; Culture Media; Ganglia, Spinal; Macrolides; Male; Nerve Regeneration; Neurites; Neurons; Phagosomes; Rats; Rats, Sprague-Dawley; Sirolimus | 2016 |
Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats.
Topics: Adenine; Animals; Apoptosis; Autophagy; Central Nervous System Agents; Disease Models, Animal; Male; Motor Activity; Neuroimmunomodulation; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Spinal Cord; Spinal Cord Ischemia | 2016 |
Proper autophagy is indispensable for angiogenesis during chick embryo development.
Topics: Adenine; Angiodysplasia; Animals; Autophagy; Autophagy-Related Proteins; Cell Movement; Chick Embryo; Chorioallantoic Membrane; Embryonic Development; Endothelium, Vascular; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Microtubule-Associated Proteins; Neovascularization, Physiologic; Sirolimus | 2016 |
Chemotherapy of mantle cell lymphoma relapsed or refractory chronic lymphocytic leukaemia.
Topics: Adenine; Antineoplastic Agents; Bendamustine Hydrochloride; Bortezomib; Chromosomes, Human, Pair 17; Cytarabine; Humans; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Mutation; Neoplasm Recurrence, Local; Piperidines; Pyrazoles; Pyrimidines; Rituximab; Sirolimus; Thalidomide; Tumor Suppressor Protein p53; Vidarabine | 2016 |
Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.
Topics: Adenine; Animals; Apoptosis; Ascorbic Acid; Autophagy; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Glioma; Lignans; Mice; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2016 |
The autophagy pathway participates in resistance to tomato yellow leaf curl virus infection in whiteflies.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Begomovirus; DNA Primers; Female; Genomics; Gossypium; Hemiptera; Insect Vectors; Male; Plant Diseases; Sirolimus | 2016 |
Nano-TiO
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Cytoprotection; Enzyme Activation; Mice; Nanoparticles; Oxidative Stress; Podocytes; Signal Transduction; Sirolimus; Titanium; TOR Serine-Threonine Kinases | 2016 |
Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance.
Topics: Adenine; Autophagy; Cells, Cultured; Culture Media; Glucose; Humans; Insulin Resistance; Membrane Proteins; Osmolar Concentration; Phosphorylation; Podocytes; Receptor, Insulin; Sirolimus | 2016 |
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Bacterial Proteins; Beclin-1; Cell Membrane; Cell Proliferation; Class III Phosphatidylinositol 3-Kinases; Dogs; Ehrlichia chaffeensis; Ehrlichiosis; Enzyme Activation; Glutamic Acid; Glutamine; Guanosine Triphosphate; HEK293 Cells; Host-Pathogen Interactions; Humans; Huntingtin Protein; Inclusion Bodies; Mutant Proteins; Protein Binding; rab5 GTP-Binding Proteins; Signal Transduction; Sirolimus; Ubiquitination | 2016 |
Associations between autophagy, the ubiquitin-proteasome system and endoplasmic reticulum stress in hypoxia-deoxygenation or ischemia-reperfusion.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Line; Cell Survival; Doxorubicin; Endoplasmic Reticulum Stress; Histone Deacetylase 6; Histone Deacetylases; Leupeptins; Lung; Male; NF-kappa B; Oxygen; Proteasome Endopeptidase Complex; Rats; Reperfusion Injury; Sirolimus; Ubiquitin | 2016 |
Role of autophagy in cellular response to infection with Orf virus Jilin isolate.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Chloroquine; Ecthyma, Contagious; Host-Pathogen Interactions; Microscopy, Electron, Transmission; Orf virus; Sheep; Sirolimus; Virus Replication | 2016 |
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Beclin-1; Cardiotoxins; Cell Survival; Doxorubicin; L-Lactate Dehydrogenase; Macrolides; Microtubule-Associated Proteins; Myocytes, Cardiac; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Autophagy is induced by anti-neutrophil cytoplasmic Abs and promotes neutrophil extracellular traps formation.
Topics: Adenine; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Autophagy; Cells, Cultured; Extracellular Traps; Healthy Volunteers; Humans; Microtubule-Associated Proteins; Neutrophils; Sirolimus | 2016 |
AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes.
Topics: Adenine; Animals; Autophagosomes; Autophagy; CD11c Antigen; Cytokines; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Interferon Regulatory Factors; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Microscopy, Electron; Microscopy, Fluorescence; RAW 264.7 Cells; RNA Interference; RNA, Small Interfering; Sirolimus; Skin; Wound Healing | 2016 |
Simulated ischemia/reperfusion-induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells.
Topics: Adenine; Autophagy; Beclin-1; Cell Death; Human Umbilical Vein Endothelial Cells; Humans; Myocardial Reperfusion Injury; Sirolimus; Transcription Factor RelA | 2016 |
Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cell Hypoxia; Cells, Cultured; Endoplasmic Reticulum Stress; Macrophages, Alveolar; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Superoxide Dismutase | 2016 |
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Caspase 3; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Microtubule-Associated Proteins; Multiple Sclerosis; Neurons; Sirolimus; Spinal Cord | 2017 |
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway.
Topics: Adenine; Antimutagenic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Cobalt; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirolimus; Tumor Suppressor Protein p53 | 2017 |
Autophagy Activation by Rapamycin Before Hypoxia-Reoxygenation Reduces Endoplasmic Reticulum Stress in Alveolar Epithelial Cells.
Topics: Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Beclin-1; Cell Hypoxia; Cell Line; Endoplasmic Reticulum Stress; Immunohistochemistry; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microtubule-Associated Proteins; Oxygen; Rats; Sirolimus; Transcription Factor CHOP; X-Box Binding Protein 1 | 2017 |
Staphylococcal lipoteichoic acid promotes osteogenic differentiation of mouse mesenchymal stem cells by increasing autophagic activity.
Topics: Actins; Adenine; Alkaline Phosphatase; Animals; Autophagy; Blotting, Western; Cell Differentiation; Cell Line; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Gene Expression; Immunosuppressive Agents; Lipopolysaccharides; Mesenchymal Stem Cells; Mice, Inbred C3H; Microtubule-Associated Proteins; Osteogenesis; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus; Staphylococcus aureus; Teichoic Acids | 2017 |
Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Hydroquinones; Microtubule-Associated Proteins; Poly (ADP-Ribose) Polymerase-1; Sirolimus; Sirtuin 1 | 2017 |
Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Diet, High-Fat; Humans; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Obesity; Palmitic Acid; Semen Analysis; Sirolimus; Spermatogenesis; Spermatozoa; Testis | 2017 |
Induction of Atypical Autophagy by Porcine Hemagglutinating Encephalomyelitis Virus Contributes to Viral Replication.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Betacoronavirus 1; Cell Line; Cell Survival; Chloroquine; Coronavirus Infections; Lysosomes; Membrane Proteins; Mice; Sirolimus; Vacuoles; Virus Replication | 2017 |
Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Biomarkers; Cell Differentiation; Cell Line; Cisplatin; Epithelial Cells; Exosomes; Female; Fetus; Fibroblasts; Gene Expression; Humans; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Nephritis; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sirolimus; Umbilical Cord | 2017 |
Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro.
Topics: Adenine; Animals; Arcuate Nucleus of Hypothalamus; Autophagy; Blotting, Western; Brain Diseases; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Glucose Tolerance Test; Hypothalamus; Immunosuppressive Agents; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Metabolism; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neurons; Oleic Acid; PC12 Cells; Rats; Receptor, Insulin; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation; Ventromedial Hypothalamic Nucleus | 2017 |
Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.
Topics: Adenine; Amyloid beta-Peptides; Apoptosis; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-Binding Protein; Humans; Membrane Potential, Mitochondrial; Neural Cell Adhesion Molecules; Neurons; Neuroprotection; Oxidative Stress; Peptide Fragments; Real-Time Polymerase Chain Reaction; Sirolimus | 2017 |
Autophagy can alleviate severe burn-induced damage to the intestinal tract in mice.
Topics: Adenine; Animals; Autophagy; Burns; Disease Models, Animal; Female; Interleukin-6; Intestinal Mucosa; Intestines; Male; Mice; Sirolimus; Tumor Necrosis Factor-alpha | 2017 |
Inhibition of autophagy by berberine enhances the survival of H9C2 myocytes following hypoxia.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Berberine; Caspase 3; Cell Hypoxia; Cell Line; Cell Survival; Microtubule-Associated Proteins; Myocytes, Cardiac; Pinellia; Rats; Sirolimus | 2017 |
Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Cell Line, Tumor; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoproterenol; Lung Neoplasms; Mammary Neoplasms, Experimental; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; RAW 264.7 Cells; Reactive Oxygen Species; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Tumor Microenvironment | 2017 |
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
Topics: Acetylcysteine; Adenine; Autophagy; Cell Line; Cell Survival; Diethylhexyl Phthalate; Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Sirolimus | 2017 |
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy.
Topics: Adenine; Angiogenesis Inhibitors; Animals; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ranibizumab; Reactive Oxygen Species; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Retinal Pigment Epithelium; Sirolimus; Swine | 2017 |
Autophagy inhibits high glucose induced cardiac microvascular endothelial cells apoptosis by mTOR signal pathway.
Topics: Adenine; Animals; Apoptosis; Caspases; Cells, Cultured; Endothelial Cells; Glucose; Heart; Male; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Autophagy protects auditory hair cells against neomycin-induced damage.
Topics: Acetylcysteine; Adenine; Animals; Anti-Bacterial Agents; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Line; Hair Cells, Auditory; Mice; Mitochondria; Neomycin; Reactive Oxygen Species; Sirolimus | 2017 |
Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway.
Topics: Adenine; Animals; Autophagy; beta Catenin; Hypoxia-Ischemia, Brain; Models, Biological; Morpholines; PC12 Cells; Rats; Sirolimus; Triazines; Wnt Signaling Pathway | 2017 |
Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway.
Topics: A549 Cells; Adenine; Antineoplastic Agents, Phytogenic; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cisplatin; Drug Combinations; Drug Synergism; Garcinia; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Plant Extracts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xanthones | 2017 |
Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cytochromes c; Diet, Ketogenic; Epilepsy; Hippocampus; Male; Mitochondria; Neurons; Neuroprotective Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Sirolimus | 2018 |
Resveratrol transcriptionally regulates miRNA-18a-5p expression ameliorating diabetic nephropathy via increasing autophagy.
Topics: Adenine; Animals; Ataxia Telangiectasia Mutated Proteins; Autophagy; Caspase 3; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Down-Regulation; Male; Mice; Mice, Obese; MicroRNAs; Microtubule-Associated Proteins; Resveratrol; RNA Interference; RNA, Small Interfering; Sirolimus; Stilbenes; Up-Regulation | 2017 |
Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 5; Cell Line; Epithelial Cells; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Host-Pathogen Interactions; Kidney; Microtubule-Associated Proteins; RNA, Small Interfering; Signal Transduction; Sirolimus; Swine; Teschovirus; Virus Replication; Wortmannin | 2018 |
Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization.
Topics: Adenine; alpha-Synuclein; Animals; Apoptosis; Autophagy; Brain; Butylamines; Chlorides; Endoplasmic Reticulum Stress; Environmental Pollutants; Manganese; Manganese Compounds; Mice, Inbred C57BL; Neurons; Phenylbutyrates; Polymerization; Signal Transduction; Sirolimus | 2018 |
Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Disease Models, Animal; Genotype; In Situ Nick-End Labeling; Mice; Motor Neurons; Muscular Atrophy, Spinal; Sirolimus | 2017 |
Autophagy involved in the activation of the Nrf2-antioxidant system in testes of heat-exposed mice.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Heat-Shock Response; Hot Temperature; Male; Mice; NF-E2-Related Factor 2; Seminiferous Tubules; Sequestosome-1 Protein; Signal Transduction; Sirolimus | 2018 |
Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity.
Topics: Adenine; Animals; Anisomycin; Biophysics; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; Indoles; Long-Term Potentiation; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Phosphorylation; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Sirolimus | 2018 |
Low-dose dexamethasone affects osteoblast viability by inducing autophagy via intracellular ROS.
Topics: Adenine; Apoptosis; Autophagy; Beclin-1; Biomarkers; Catalase; Cell Line; Cell Survival; Dexamethasone; Fetus; Gene Expression; Glucocorticoids; Hormesis; Humans; Microtubule-Associated Proteins; Osteoblasts; Reactive Oxygen Species; Sirolimus | 2018 |
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lignans; Macrolides; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
The novel involvement of podocyte autophagic activity in the pathogenesis of lupus nephritis.
Topics: Adenine; Adolescent; Adult; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Disease Progression; Female; Humans; Lupus Nephritis; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Podocytes; Sirolimus; Young Adult | 2018 |
Interplay between autophagy and apoptosis in lead(II)-induced cytotoxicity of primary rat proximal tubular cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cells, Cultured; Kidney Tubules, Proximal; Lead; Microtubule-Associated Proteins; Rats; Sirolimus | 2018 |
Schwann-Cell Autophagy, Functional Recovery, and Scar Reduction After Peripheral Nerve Repair.
Topics: Adenine; Animals; Autophagy; Cicatrix; Male; Nerve Regeneration; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Sirolimus | 2018 |
Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis.
Topics: Adenine; Animals; Autophagy; Carrier Proteins; Endotoxemia; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Sepsis; Shock, Septic; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha | 2018 |
Mitophagy Plays a Protective Role in Iodinated Contrast-Induced Acute Renal Tubular Epithelial Cells Injury.
Topics: Acute Kidney Injury; Adenine; Apoptosis; Autophagy; Cell Line; Contrast Media; Epithelial Cells; Humans; Iodine; Iohexol; Kidney Tubules; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondria; Mitophagy; Reactive Oxygen Species; Sirolimus; Triiodobenzoic Acids | 2018 |
Role of Hypoxia-Inducible Factors 1α (HIF1α) in SH-SY5Y Cell Autophagy Induced by Oxygen-Glucose Deprivation.
Topics: Adenine; Apoptosis; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Gene Knockdown Techniques; Glucose; Green Fluorescent Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Models, Biological; Oxygen; RNA, Small Interfering; Sirolimus | 2018 |
Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Macrolides; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Syzygium; TOR Serine-Threonine Kinases | 2018 |
Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.
Topics: Adenine; Autophagy; Gene Expression Regulation, Fungal; Mycelium; Nutrients; Oxidative Stress; Paracoccidioides; Paracoccidioidomycosis; Saccharomyces cerevisiae; Sirolimus | 2018 |
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chromones; Cobalt; Disease Models, Animal; Erythropoietin; Humans; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Morpholines; Peptide Fragments; Proto-Oncogene Proteins c-akt; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Enhancing Autophagy Protects Against Sepsis-Induced Neuromuscular Dysfunction Associated with Qualitative Changes to Acetylcholine Receptors.
Topics: Adenine; Animals; Autophagy; Cecum; Ligation; Male; Punctures; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Sepsis; Sirolimus; Sphingosine-1-Phosphate Receptors | 2019 |
ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway.
Topics: Acetylcysteine; Adenine; Autophagy; Beclin-1; Blood Platelets; Cell Adhesion; Humans; Lipoproteins, LDL; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells.
Topics: Adenine; AMP-Activated Protein Kinase Kinases; Animals; Autophagy; Cell Proliferation; Hot Temperature; Human Umbilical Vein Endothelial Cells; Humans; Macrolides; Neovascularization, Physiologic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; HCT116 Cells; Humans; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus | 2018 |
Deficiency of apoptosis-stimulating protein two of p53 promotes liver regeneration in mice by activating mammalian target of rapamycin.
Topics: Adenine; Animals; Autophagy; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation; Haploinsufficiency; Hepatocytes; Liver Regeneration; Mechanistic Target of Rapamycin Complex 1; Mice; Sirolimus; Tumor Suppressor Proteins | 2018 |
The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy.
Topics: Adenine; Animals; Autophagy; Beclin-1; Caspase 3; Cell Survival; Microtubule-Associated Proteins; Myocytes, Cardiac; Rats; Rats, Wistar; Selenium; Sirolimus; T-2 Toxin | 2019 |
Identifying key barriers in cationic polymer gene delivery to human T cells.
Topics: Adenine; Autophagy; Carbocyanines; Cations; Cell Survival; HeLa Cells; Humans; Hydrogen-Ion Concentration; Jurkat Cells; Microscopy, Confocal; Plasmids; Polymers; Sirolimus; T-Lymphocytes; Transfection | 2019 |
Aged kidneys are refractory to autophagy activation in a rat model of renal ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Adenine; Age Factors; Animals; Apoptosis; Autophagosomes; Autophagy; Beclin-1; Blood Urea Nitrogen; Caspase 3; Creatinine; Disease Models, Animal; Kidney; Male; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2019 |
Inhibition of mitochondrial autophagy protects donor lungs for lung transplantation against ischaemia-reperfusion injury in rats via the mTOR pathway.
Topics: Adenine; Animals; Autophagy; Endothelial Cells; Humans; Lung; Lung Transplantation; Mitochondria; Rats; Reperfusion Injury; Signal Transduction; Sirolimus; Tissue Donors; TOR Serine-Threonine Kinases | 2019 |
The effect of autophagy on the survival and invasive activity of Eimeria tenella sporozoites.
Topics: Adenine; Adenosine Triphosphate; Autophagosomes; Autophagy; Eimeria tenella; Sirolimus; Sporozoites | 2019 |
Haemophilus parasuis infection in 3D4/21 cells induces autophagy through the AMPK pathway.
Topics: Adenine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Haemophilus parasuis; Host-Pathogen Interactions; Luminescent Proteins; Macrophages, Alveolar; Microtubule-Associated Proteins; Oxazines; Protein Isoforms; Red Fluorescent Protein; Ribonucleotides; Signal Transduction; Sirolimus; Swine; Virulence | 2019 |
Follistatin-Like 1 Attenuates Ischemia/Reperfusion Injury in Cardiomyocytes via Regulation of Autophagy.
Topics: Adenine; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Cell Survival; Follistatin-Related Proteins; Models, Biological; Myocardial Reperfusion Injury; Myocytes, Cardiac; Sirolimus | 2019 |
Inhibition of Autophagy Attenuated Intestinal Injury After Intestinal I/R via mTOR Signaling.
Topics: Adenine; Animals; Autophagy; Drug Evaluation, Preclinical; Intestinal Diseases; Intestinal Mucosa; Male; Malondialdehyde; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Superoxide Dismutase; TOR Serine-Threonine Kinases | 2019 |
Reciprocal Regulation of Chaperone-Mediated Autophagy/Microautophagy and Exosome Release.
Topics: Adenine; Ammonium Chloride; Cell Line; Chaperone-Mediated Autophagy; Exosomes; Humans; Lysosomal-Associated Membrane Protein 2; Macrolides; Microautophagy; Mycophenolic Acid; RNA, Small Interfering; Sirolimus | 2019 |
Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway.
Topics: Actins; Adenine; Animals; Autophagy; Beclin-1; Hepatic Stellate Cells; Insulin-Like Growth Factor Binding Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinase; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Transfection; Transforming Growth Factor beta1 | 2020 |
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scavengers; Inflammation; Interleukin-6; Mice; Microtubule-Associated Proteins; Muscle, Skeletal; Oxidative Stress; Palmitates; Reactive Oxygen Species; Sequestosome-1 Protein; Sirolimus; Tumor Necrosis Factor-alpha | 2020 |
Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats.
Topics: Adenine; Animals; Apoptosis; Arthritis, Experimental; Autophagy; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease Models, Animal; Male; Rats, Sprague-Dawley; Sirolimus | 2019 |
Dexmedetomidine Protects Against Oxygen-Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway.
Topics: Adenine; Animals; Astrocytes; Autophagy; Cell Hypoxia; Cells, Cultured; Dexmedetomidine; Drug Evaluation, Preclinical; Glucose; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein | 2020 |
The autophagic inducer and inhibitor display different activities on the meiotic and developmental competencies of porcine oocytes derived from small and medium follicles.
Topics: Adenine; Animals; Autophagy; Cell Size; Cells, Cultured; Cumulus Cells; Embryonic Development; Female; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Oogenesis; Ovarian Follicle; Parthenogenesis; Sirolimus; Swine | 2019 |
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.
Topics: Adenine; Animals; Atherosclerosis; Autophagy; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Progression; Foam Cells; Hepatocyte Growth Factor; Lipid Metabolism; Lipoproteins, LDL; Mice; Proto-Oncogene Proteins; Quercetin; RAW 264.7 Cells; Sirolimus; Up-Regulation | 2019 |
Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Chloroquine; Intracellular Signaling Peptides and Proteins; Lactoferrin; Mice; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Sirolimus | 2020 |
Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation.
Topics: Adenine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Beclin-1; Caspase 3; Cell Proliferation; Disease Models, Animal; Ischemia; Kidney; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2020 |
Impairment of Autophagy Causes Superoxide Formation and Caspase Activation in 661 W Cells, a Cell Line for Cone Photoreceptors, under Hyperglycemic Conditions.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Survival; Diabetic Retinopathy; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Mice; Microtubule-Associated Proteins; Models, Biological; Oxidative Stress; Retinal Cone Photoreceptor Cells; Sequestosome-1 Protein; Sirolimus; Superoxides | 2020 |
Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Cell Survival; Chloroquine; Fish Proteins; Gene Expression Regulation; Gills; Microtubule-Associated Proteins; Nutrients; Oncorhynchus mykiss; Pharmaceutical Preparations; Serum; Sirolimus; Time Factors; Trichothecenes | 2020 |
Role of autophagy in nerve cell apoptosis in mice infected with street rabies virus.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain; Disease Models, Animal; Fluorescent Antibody Technique, Direct; Mice; Neurons; Rabies; Rabies virus; Sirolimus; Viral Proteins; Virus Replication | 2020 |
The Role of Autophagy-Mediated Dengue Virus Antibody-Dependent Enhancement Infection of THP-1 Cells.
Topics: Adenine; Antibodies, Viral; Antibody-Dependent Enhancement; Autophagosomes; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Proteins; Dengue; Dengue Virus; Humans; Sirolimus; THP-1 Cells; Transcriptome | 2020 |
Autophagy alleviates mitochondrial DAMP-induced acute lung injury by inhibiting NLRP3 inflammasome.
Topics: Acute Lung Injury; Adenine; Alarmins; Animals; Autophagy; Cytokines; Disease Models, Animal; Inflammasomes; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Pneumonia; Sirolimus | 2021 |
Arsenic-induced autophagy regulates apoptosis in AML-12 cells.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Autophagy; Cell Line; Cell Survival; Mice; Microtubule-Associated Proteins; Sirolimus | 2021 |
Rapamycin and 3-Methyladenine Influence the Apoptosis, Senescence, and Adipogenesis of Human Adipose-Derived Stem Cells by Promoting and Inhibiting Autophagy: An In Vitro and In Vivo Study.
Topics: Adenine; Adipogenesis; Adipose Tissue; Apoptosis; Autophagy; Humans; Sirolimus; Stem Cells | 2021 |
Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis.
Topics: Adenine; Animals; Atherosclerosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Gene Knockdown Techniques; Humans; Inflammasomes; Lipid Metabolism; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; NLR Family, Pyrin Domain-Containing 3 Protein; Plaque, Atherosclerotic; Polysaccharides; Sequestosome-1 Protein; Sirolimus | 2020 |
Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy.
Topics: Adenine; Aging; Animals; Antioxidants; Apoptosis; Drugs, Chinese Herbal; Fallopia multiflora; Male; Membrane Potential, Mitochondrial; Mitophagy; Rats; Sirolimus; Skin; Skin Aging | 2021 |
Autophagy contributes to angiotensin II induced dysfunction of HUVECs.
Topics: Acetophenones; Adenine; Angiotensin II; Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Benzimidazoles; Biphenyl Compounds; Decanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxy Acids; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Signal Transduction; Sirolimus; Tetrazoles; Time Factors | 2021 |
Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms.
Topics: Adenine; Anthracenes; Autophagy; Berberine; Cell Proliferation; Cell Survival; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; MAP Kinase Signaling System; Protective Agents; Sirolimus | 2021 |
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cerebral Cortex; Class III Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Female; Male; Methylmercury Compounds; Neurons; Rats, Wistar; Sirolimus; TOR Serine-Threonine Kinases | 2021 |
Letter on Rapamycin and 3-Methyladenine Influence the Apoptosis, Senescence, and Adipogenesis of Human Adipose-Derived Stem Cells by Promoting and Inhibiting Autophagy: An In Vitro and In Vivo Study.
Topics: Adenine; Adipogenesis; Apoptosis; Autophagy; Cells, Cultured; Humans; Sirolimus; Stem Cells | 2022 |
Applicability of different cell line-derived dendritic cell-like cells in autophagy research.
Topics: Adenine; Autophagy; Autophagy-Related Proteins; Cell Differentiation; Cytokines; Dendritic Cells; Flow Cytometry; Genotype; HL-60 Cells; Humans; Macrolides; Microscopy, Fluorescence; Monocytes; Phenotype; Polymorphism, Single Nucleotide; Sirolimus; THP-1 Cells; U937 Cells | 2021 |
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Autophagy; Behavior, Animal; Dihydroxyphenylalanine; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Male; Motor Activity; Nerve Degeneration; NF-E2-Related Factor 2; Oleanolic Acid; Parkinsonian Disorders; Phenotype; Rats, Sprague-Dawley; Repressor Proteins; Rotenone; Signal Transduction; Sirolimus | 2021 |
Restoration of Parkinson's Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson's Disease in Mice.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; MTOR Inhibitors; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Parkinson Disease, Secondary; Signal Transduction; Sirolimus; Substantia Nigra; TOR Serine-Threonine Kinases; Trehalose | 2021 |
Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL-33 signaling in a mouse model of skin wound healing.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Disease Models, Animal; Inflammation; Interleukin-33; Male; Mice; Mice, Inbred ICR; Signal Transduction; Sirolimus; Skin; Wound Healing; YAP-Signaling Proteins | 2021 |
Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells.
Topics: Adenine; Aedes; Animals; Autophagy; Cell Line; Dengue; Dengue Virus; Mosquito Vectors; Sirolimus; Virus Replication | 2021 |
Octreotide activates autophagy to alleviate lipopolysaccharide-induced human pulmonary epithelial cell injury by inhibiting the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.
Topics: Acetates; Adenine; Autophagy; Benzopyrans; Cell Line; Cell Survival; Humans; Lipopolysaccharides; Lung Injury; Models, Biological; Octreotide; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
The Effect of Rapamycin and Ibrutinib on Antibody Responses to Adeno-Associated Virus Vector-Mediated Gene Transfer.
Topics: Adenine; Antibody Formation; Capsid Proteins; Dependovirus; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Piperidines; Sirolimus | 2022 |