adenine has been researched along with simvastatin in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Blazejewski, S; Dhumeaux, D; Mallat, A; Mavier, P; Preaux, AM; Rosenbaum, J | 1 |
| Acton, SM; Barr, HA; Davidson, KG; Nicholas, TE | 1 |
| Balduini, W; Buonocore, G; Carloni, S | 1 |
| de Serres, M; Gould, E; Johnson, M; Kim, J; Lou, Y; Mayers, D; Pietropaolo, K; Piscitelli, S; White, S; Zhou, XJ | 1 |
| Abais, JM; Boini, KM; Chen, Y; Li, PL; Li, X; Riebling, CR; Wei, YM; Xu, M; Zhang, Y | 1 |
| Cha, BK; Hwang, KE; Jeong, ET; Jung, JW; Kim, HR; Kim, YS; Kwon, SJ; Oh, SH; Park, DS; Yoon, KH | 1 |
| Cui, R; Ding, T; Gu, W; Guo, X; Han, F; Li, X; Peng, J; Xu, W | 1 |
| Balduini, W; Carloni, S | 1 |
| Adorni, MP; Biancorosso, N; Bressan, A; Brilli, E; Chen, H; Dall'Acqua, S; Faggin, E; Ferri, N; Lupo, MG; Neutel, C; Rattazzi, M; Salvalaio, M; Sut, S; Tarantino, G; Vivian, G | 1 |
1 trial(s) available for adenine and simvastatin
| Article | Year |
|---|---|
Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
Topics: Adenine; Androstenes; Anti-HIV Agents; Atazanavir Sulfate; Atorvastatin; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Darunavir; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Interactions; Emtricitabine; Ethinyl Estradiol; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Least-Squares Analysis; Linear Models; Lopinavir; Male; Oligopeptides; Organophosphonates; Patient Safety; Phosphinic Acids; Pyridines; Pyrimidines; Pyrroles; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Risk Assessment; Ritonavir; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Tenofovir | 2012 |
10 other study(ies) available for adenine and simvastatin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Effect of simvastatin, an inhibitor of hydroxy-methylglutaryl coenzyme A reductase, on the growth of human Ito cells.
Topics: Actins; Adenine; Analysis of Variance; Autoradiography; Cell Division; Cells, Cultured; Cholesterol, LDL; Desmin; DNA; Farnesol; Fibroblasts; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isopentenyladenosine; Liver; Lovastatin; Mevalonic Acid; Simvastatin | 1994 |
Effect of lowering serum cholesterol on the composition of surfactant in adult rat lung.
Topics: Adenine; Animals; Anticholesteremic Agents; Cholesterol; In Vitro Techniques; Lipids; Lovastatin; Lung; Lung Compliance; Male; Organ Size; Phospholipids; Proteolipids; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Rats; Rats, Inbred Strains; Simvastatin; Surface Tension | 1997 |
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury.
Topics: Adenine; Analysis of Variance; Androstadienes; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Count; Cerebral Cortex; Hippocampus; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Simvastatin; Sirolimus; Wortmannin | 2008 |
Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Calcium-Binding Proteins; Calponins; Cell Proliferation; Cells, Cultured; Coronary Vessels; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lysosomes; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microtubule-Associated Proteins; Muscle Cells; Phenotype; rac1 GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Simvastatin; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Mesothelioma; Mesothelioma, Malignant; Mice, Nude; Microtubule-Associated Proteins; Pemetrexed; Pepstatins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Simvastatin; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma.
Topics: Adenine; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cytokines; Disease Models, Animal; Extracellular Matrix; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon-gamma; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Myocytes, Smooth Muscle; Ovalbumin; Simvastatin; Up-Regulation | 2017 |
Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation.
Topics: Adenine; Animals; Animals, Newborn; Autophagy; Brain Damage, Chronic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin; Sirtuin 1 | 2020 |
Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.
Topics: Acyl Coenzyme A; Adenine; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cholesterol; Cysteine; Dietary Supplements; Humans; Hypercholesterolemia; Iron; Magnesium; Male; Rats, Sprague-Dawley; Receptors, LDL; Renal Insufficiency, Chronic; Simvastatin; Uremia; Vascular Calcification | 2020 |