adenine and s-adenosylmethionine

adenine has been researched along with s-adenosylmethionine in 103 studies

Research

Studies (103)

TimeframeStudies, this research(%)All Research%
pre-199048 (46.60)18.7374
1990's15 (14.56)18.2507
2000's16 (15.53)29.6817
2010's16 (15.53)24.3611
2020's8 (7.77)2.80

Authors

AuthorsStudies
Lehotay, DC; LePage, J; Rockman-Greenberg, C; Thompson, JR1
Butt, VS; Poulton, JE1
Choih, SJ; Ferro, AJ; Shapiro, SK1
Johnston, JM; Kredich, NM1
Deeprose, RD; Duncan, GS; Harvey, RJ; Wolberg, G; Zimmerman, TP1
Mitsuda, H; Nadamoto, T; Nakajima, K1
Nishimura, S; Tanaka, Y; Taya, Y1
Morgan, SA; Shulman, RW; Warner, JR1
Balis, ME; Maschio, FA; Tscherne, JS; Wainfan, E1
Tuck, MT1
Balzarini, J; Cools, M; De Clercq, E1
Fraher, LJ; McFadden, RG1
Cools, M; De Clercq, E1
Borchardt, RT; Cools, M; De Clercq, E; Hasobe, M1
Borchardt, RT; Hasobe, M; Holý, A; Votruba, I1
Henney, HR; Zhu, CM1
Cumaraswamy, A; Henney, HR2
Cohen, SS1
Barber, JR; Brunauer, LS; Clarke, S; Morimoto, BH1
Ono, A; Pogolotti, AL; Santi, DV; Subramaniam, R1
De Clercq, E; Durbin, RK; Stollar, V1
Arteca, RN; Bachman, JM; Phillips, AT; Tsai, DS1
Samet, MK1
Refsum, H; Svardal, A; Ueland, PM1
Tarr, HL1
Krüger, FW; Rücker, U; Wiessler, M1
Granieri, A; Scarano, E; Tosi, L1
Baxter, CS; Byvoet, P1
Follmann, H; Gremels, G1
Meedel, TH; Pizer, LI1
Anderson, WM; Love, SH; Remy, CN; Sipe, JE1
Hutson, NK; Shapiro, SK; Spence, KD1
Degnen, ST; Morris, NR1
Dainko, JL; Schlenk, F; Zydek-Cwick, CR1
Pegg, AE1
Borek, E; Ryan, AM1
Borek, E; Scarborough, GA; Wong, RS1
Curri, SB1
Estes, LW; Farber, E; Shinozuka, H1
Spence, KD1
Chiang, PK; Morita, Y; Siraganian, RP1
Morita, Y; Siraganian, RP1
Ahl, R1
Benyon, RC; Church, MK; Holgate, ST1
Aksamit, RR; Backlund, PS1
Debov, SS; Földes, I; Nikolskaya, II; Somogyi, PA1
Chun, BG; Kim, S; Paik, WK1
Hjelmgren, T; Jacobsson, A; Lindahl, T; Olsson, M; Rydberg, B1
Barrows, LR; Magee, PN1
Eloranta, TO; Kajander, EO; Raina, AM1
Kredich, NM; Pike, MC; Snyderman, R1
Cartenì-Farina, M; Della Ragione, F; Galletti, P; Giordano, F; Manna, C; Oliva, A1
Ihara, M; Nishimura, S; Taya, Y1
Cheng, X1
Dryden, DT; Murray, NE; Willcock, DF1
Mashhoon, N; Reich, NO1
Guschlbauer, W1
Fojtová, M; Holý, A; Kovarík, A; Votruba, I1
Kumazawa, A; Saeki, S; Sugiyama, K; Zhou, H1
Mita, M; Nagahama, Y; Saneyoshi, M; Yoshikuni, M1
Babaie, E; Gebhardt, K; Lindqvist, BH; Shokraei, A1
Gowher, H; Jeltsch, A1
Churchill, ME; Gumport, RI; Joachimiak, A; Scavetta, RD; Szegedi, S; Thomas, CB; Walsh, MA1
Gumport, RI; Reich, NO; Szegedi, SS1
Blumenthal, RM; Cheng, X1
Goedecke, K; Goody, RS; Pignot, M; Scheidig, AJ; Weinhold, E1
Mita, M1
Smolenski, RT1
REMY, CN1
SHAPIRO, SK1
YALL, I1
Hanna, GM1
Buckle, M; Evdokimov, AA; Hattman, S; Malygin, EG; Sclavi, B; Zinoviev, VV1
Fukada, S; Kawagishi, H; Morita, T; Sekiya, A; Sugiyama, K1
Fukada, S; Morita, T; Setoue, M; Sugiyama, K1
Basu, I; Belbin, TJ; Cordovano, G; Evans, GB; Furneaux, RH; Guha, C; Gutierrez, JA; Schramm, VL; Tyler, PC1
Bale, S; Brooks, WH; Ealick, SE; Guida, WC; McCloskey, DE; Moss, TH; Pegg, AE; Secrist, JA; Tiwari, A; Valiyaveettil, J1
Hunter, CN; McLean, S1
Barbey, C; Golinelli-Pimpaneau, B; Guelorget, A; Guérineau, V; Li, X; Roovers, M1
Babic, F; Bujnicki, JM; Husain, N; Koscinski, L; Maravic-Vlahovicek, G; Obranic, S; Seetharaman, J; Sivaraman, J1
Basu, I; Belbin, TJ; Cassera, MB; Dong, X; Evans, GB; Guha, C; Hemeon, I; Locker, J; Merino, EF; Schramm, VL1
Cornell, KA; Parveen, N1
Stubbe, J1
Brzezinski, K; Dauter, Z; Jaskolski, M1
Anderson, PS; Hong-Geller, E; Martí-Arbona, R; Nowak-Lovato, KL; Teshima, M; Unkefer, CJ; Unkefer, PJ1
Entian, KD; Kötter, P; Lamberth, S; Peifer, C; Sharma, S; Watzinger, P1
Hell, R; Moffatt, B; Saechao, MC; Sauter, M; Wirtz, M1
Forster, AC; Liljeruhm, J; Punekar, AS; Selmer, M; Shepherd, TR1
Golinelli-Pimpaneau, B; Guelorget, A; Guérineau, V; Hamdane, D1
Bridwell-Rabb, J; Drennan, CL; Liu, HW; Sun, HG; Zhong, A1
Lilla, EA; Yokoyama, K1
Wang, SC1
Amaral, MS; Arni, RK; Coronado, MA; de Moraes, FR; Eberle, RJ; Olivier, DS; Peinado, RDS1
Burley, GA; Cuetos, A; Frese, A; Grogan, G; Hoskisson, PA; Humphreys, LD; McKean, IJW; Sadler, JC1
Kazimierczuk, K; Nawrocka, EK; Perlinska, AP; Setny, P; Stasiulewicz, A; Sulkowska, JI1
Ahmed-Belkacem, R; Canard, B; Debart, F; Decroly, E; Guiraud, M; Sutto-Ortiz, P; Vasseur, JJ1
Fukumoto, K; Fustin, JM; Hayes, A; Ito, K; Okamura, H; Saer, B; Taylor, G; Toriba, Y; Yamano, M; Ye, S1
Czekster, CM; da Silva, RG; Fisher, G; Galliford, A; Gloster, TM; Krishna, NB; Kumar, A; Kumar, P; Lalitha, R; Leo, CJ; Muthuraj, L; Oehler, V; Raju, D; Shirran, SL; Sigamani, G; Sutherland, E; Sweeney, P; Synowsky, S1
Chen, H; Chen, J; Chen, Y; Hu, R; Lin, X; Liu, L; Xiang, W; Yao, C1
Blumenthal, RM; Cheng, X; Ciogli, A; Fiorentino, F; Hajian, T; Horton, JR; Hüben, M; Mai, A; Mazzoccanti, G; Menna, M; Ren, R; Rotili, D; Vedadi, M; Weinhold, E; Yu, D; Zhang, X; Zhou, J1
Blumenthal, RM; Cheng, X; Deng, Y; Hajian, T; Horton, JR; Huang, R; Iyamu, ID; Mai, A; Rotili, D; Vedadi, M; Yu, D; Zhang, X; Zhou, J1
Barelier, S; Canard, B; Colmant, A; Coutard, B; Debart, F; Decroly, E; Delpal, A; Hausdorff, M; Nicollet, L; Touret, F; Vasseur, JJ1

Reviews

10 review(s) available for adenine and s-adenosylmethionine

ArticleYear
The formation of internal 6-methyladenine residues in eucaryotic messenger RNA.
    The International journal of biochemistry, 1992, Volume: 24, Issue:3

    Topics: Adenine; Animals; Eukaryotic Cells; Humans; Methylation; RNA, Messenger; S-Adenosylmethionine

1992
Inhibitors of adenosine deaminase and the development of antiviral agents.
    Annals of the New York Academy of Sciences, 1985, Volume: 451

    Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Cytarabine; Deoxyadenosines; Drug Synergism; Herpes Simplex; Humans; Interferons; Mice; Nucleoside Deaminases; S-Adenosylhomocysteine; S-Adenosylmethionine

1985
Chemotaxis and methylation in a macrophage cell line.
    Survey of immunologic research, 1983, Volume: 2, Issue:2

    Topics: Adenine; Adenosine; Animals; Blood Proteins; Cell Line; Chemotaxis, Leukocyte; Guinea Pigs; Humans; Macrophages; Methylation; Mice; Phosphatidylethanolamines; Rabbits; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin

1983
Structure and function of DNA methyltransferases.
    Annual review of biophysics and biomolecular structure, 1995, Volume: 24

    Topics: Adenine; Amino Acid Sequence; Binding Sites; Catechol O-Methyltransferase; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Methylation; Methyltransferases; Molecular Sequence Data; Protein Conformation; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific)

1995
"Small is beautiful": major modifications in DNA structure or dynamics by small substituents or ligands.
    Acta biochimica Polonica, 1996, Volume: 43, Issue:1

    Topics: Adenine; Base Sequence; Deoxyribose; DNA; Guanine Nucleotides; Guanosine; Ligands; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Polydeoxyribonucleotides; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific)

1996
1-Methyladenine: a starfish oocyte maturation-inducing substance.
    Zygote (Cambridge, England), 2000, Volume: 8 Suppl 1

    Topics: Adenine; Adenosine Triphosphate; Animals; Cell-Free System; DNA, Complementary; Evolution, Molecular; Female; GTP-Binding Proteins; Hormones; Invertebrate Hormones; Meiosis; Methylation; Neuropeptides; Oocytes; Oogenesis; Ovarian Follicle; Phylogeny; Receptors, Neuropeptide; S-Adenosylmethionine; Signal Transduction; Starfish

2000
Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism.
    Molecular microbiology, 2011, Volume: 79, Issue:1

    Topics: 4-Butyrolactone; Adenine; Bacteria; Biofilms; Homoserine; Lactones; Metabolic Networks and Pathways; Methionine; Models, Biological; N-Glycosyl Hydrolases; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine; Vitamins

2011
Methionine salvage and S-adenosylmethionine: essential links between sulfur, ethylene and polyamine biosynthesis.
    The Biochemical journal, 2013, Apr-15, Volume: 451, Issue:2

    Topics: Adenine; Arabidopsis; Carbon; Cytosol; Ethylenes; Gene Expression Regulation, Plant; Iron; Methionine; Oryza; Polyamines; S-Adenosylmethionine; Sulfur

2013
C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products.
    Natural product reports, 2018, 07-18, Volume: 35, Issue:7

    Topics: Adenine; Bacterial Proteins; Bacteriochlorophylls; Biological Products; Carbon; Coenzymes; Endopeptidases; Enzymes; Hydrolases; Molybdenum; S-Adenosylmethionine; Tunicamycin; Vitamin K 2

2018
Cobalamin-dependent radical S-adenosyl-l-methionine enzymes in natural product biosynthesis.
    Natural product reports, 2018, 08-15, Volume: 35, Issue:8

    Topics: Adenine; Aminobutyrates; Biological Products; Enzymes; Fosfomycin; Gentamicins; Methylation; S-Adenosylmethionine; Shewanella; Thiostrepton; Vitamin B 12

2018

Other Studies

93 other study(ies) available for adenine and s-adenosylmethionine

ArticleYear
Blood acylcarnitine levels in normal newborns and heterozygotes for medium-chain acyl-CoA dehydrogenase deficiency: a relationship between genotype and biochemical phenotype?
    Journal of inherited metabolic disease, 2004, Volume: 27, Issue:1

    Topics: Acyl-CoA Dehydrogenase; Adenine; Carnitine; Diagnosis, Differential; Gene Frequency; Genotype; Guanine; Heterozygote; Humans; Infant, Low Birth Weight; Infant, Newborn; Metabolism, Inborn Errors; Osmolar Concentration; Phenotype

2004
Purification and properties of S-adenosyl-L-homocysteine hydrolase from leaves of spinach beet.
    Archives of biochemistry and biophysics, 1976, Volume: 172, Issue:1

    Topics: Adenine; Cysteine; Deoxyadenosines; Homocysteine; Hydrogen-Ion Concentration; Hydrolases; Kinetics; Methionine; Plants; S-Adenosylhomocysteine; S-Adenosylmethionine

1976
Function of S-adenosylmethionine in germinating yeast ascospores.
    Journal of bacteriology, 1977, Volume: 131, Issue:1

    Topics: Adenine; Adenosylmethionine Decarboxylase; Fungal Proteins; Leucine; Methionine; Methionine Adenosyltransferase; Methyltransferases; S-Adenosylmethionine; Saccharomyces cerevisiae; Species Specificity; Spores, Fungal; tRNA Methyltransferases

1977
Inhibition of methylation by adenosine in adenosine deaminase-inhibited, phytohemagglutinin-stimulated human lymphocytes.
    Journal of immunology (Baltimore, Md. : 1950), 1979, Volume: 123, Issue:1

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; DNA; Homocysteine; Humans; Lymphocyte Activation; Methylation; Nucleoside Deaminases; Phytohemagglutinins; S-Adenosylhomocysteine; S-Adenosylmethionine

1979
Inhibition of immune cell function by adenosine: biochemical studies.
    Advances in experimental medicine and biology, 1979, Volume: 122B

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Animals; Cytotoxicity, Immunologic; Homocysteine; Imidazoles; Lymphocytes; Methionine; Mice; S-Adenosylmethionine; Theophylline; Uridine

1979
The relation between purine metabolism and flavinogenesis in Eremothecium ashbyii. The identification of S-adenosylmethionine and S-adenosylhomocysteine accumulated in non-growing cells of E. ashbyii.
    Journal of nutritional science and vitaminology, 1977, Volume: 23, Issue:2

    Topics: Adenine; Ascomycota; Culture Media; Dose-Response Relationship, Drug; Homocysteine; Riboflavin; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomycetales

1977
Cell-free biosynthesis of discadenine, a spore germination inhibitor of Dictyostelium discoideum.
    FEBS letters, 1978, May-15, Volume: 89, Issue:2

    Topics: Adenine; Cell Differentiation; Cell-Free System; Dictyostelium; Myxomycetes; S-Adenosylhomocysteine; S-Adenosylmethionine; Spores, Fungal; Transferases

1978
Kinetics of labeling of the S-adenosylmethionine pool of Saccharomyces cerevisiae.
    Journal of bacteriology, 1976, Volume: 125, Issue:3

    Topics: Adenine; Carbon Radioisotopes; Fungal Proteins; Kinetics; RNA, Ribosomal; S-Adenosylmethionine; Saccharomyces cerevisiae; Spheroplasts; Tritium

1976
Time dependence of ethionine-induced changes in rat liver transfer RNA methylation.
    Cancer research, 1977, Volume: 37, Issue:3

    Topics: Adenine; Animals; Cytosine; Drug Interactions; Ethionine; Female; Guanine; Liver; Methylation; Rats; RNA, Transfer; S-Adenosylmethionine; tRNA Methyltransferases; Uracil

1977
Mechanism of antiviral and cytotoxic action of (+/-)-6' beta-fluoroaristeromycin, a potent inhibitor of S-adenosylhomocysteine hydrolase.
    Molecular pharmacology, 1991, Volume: 39, Issue:6

    Topics: Adenine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Division; Homocysteine; Hydrolases; Mice; Nucleic Acids; Phosphorylation; Protein Biosynthesis; S-Adenosylhomocysteine; S-Adenosylmethionine

1991
Inhibitors of membrane transmethylation reactions prevent the lymphocyte chemokinetic response.
    Immunology letters, 1990, Volume: 26, Issue:3

    Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Bradykinin; Chemotaxis, Leukocyte; Colchicine; Homocysteine; Humans; Interleukin-16; Leukocytes, Mononuclear; Lymphocytes; Lymphokines; Male; Membrane Lipids; Methylation; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Second Messenger Systems

1990
Influence of S-adenosylhomocysteine hydrolase inhibitors on S-adenosylhomocysteine and S-adenosylmethionine pool levels in L929 cells.
    Biochemical pharmacology, 1990, Nov-15, Volume: 40, Issue:10

    Topics: Adenine; Adenosylhomocysteinase; Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Hydrolases; L Cells; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Vaccinia virus

1990
Mechanism of the synergistic antiviral and cytostatic activity of (RS)-3-(adenin-9-yl)-2-hydroxypropanoic acid isobutyl ester and D,L-homocysteine.
    Biochemical pharmacology, 1990, Jan-01, Volume: 39, Issue:1

    Topics: Adenine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Drug Synergism; Homocysteine; Hydrolases; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Vaccinia virus

1990
2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells.
    Biochemical pharmacology, 1990, May-15, Volume: 39, Issue:10

    Topics: Adenine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Line; Chromatography, High Pressure Liquid; Hydrolases; L Cells; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Vaccinia; Vaccinia virus; Virus Replication

1990
Intracellular polyamine patterns during encystment of Physarum flavicomum.
    Canadian journal of microbiology, 1990, Volume: 36, Issue:5

    Topics: Adenine; Physarum; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine

1990
Acid-soluble purine and pyrimidine derivatives of growing, encysting and encystment-inhibited amoebae.
    Cell biochemistry and function, 1990, Volume: 8, Issue:3

    Topics: Adenine; Carbon Radioisotopes; Cell Division; Chromatography, High Pressure Liquid; Physarum; Purine Nucleotides; Pyrimidine Nucleotides; S-Adenosylmethionine

1990
Adenine salvage enzymes and intracellular nucleotide triphosphate content in Physarum flavicomum amoebae during growth and development.
    Canadian journal of microbiology, 1989, Volume: 35, Issue:5

    Topics: Adenine; Adenine Phosphoribosyltransferase; Nucleotides; Physarum; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine

1989
Metabolism of S-adenosyl-L-methionine in intact human erythrocytes.
    Biochimica et biophysica acta, 1986, May-29, Volume: 886, Issue:3

    Topics: Adenine; Cells, Cultured; Culture Media; Cyclic AMP; Erythrocytes; Humans; Magnesium; S-Adenosylmethionine

1986
On the mechanism of DNA-adenine methylase.
    The Journal of biological chemistry, 1988, Jun-05, Volume: 263, Issue:16

    Topics: Adenine; Base Sequence; Chromatography, High Pressure Liquid; Deoxyadenosines; Isomerism; Magnetic Resonance Spectroscopy; Methyltransferases; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific)

1988
SVLM21, a mutant of Sindbis virus able to grow in Aedes albopictus cells in the absence of methionine, shows increased sensitivity to S-adenosylhomocysteine hydrolase inhibitors such as neplanocin A.
    Virology, 1988, Volume: 163, Issue:1

    Topics: Adenine; Adenosine; Adenosylhomocysteinase; Aedes; Animals; Antiviral Agents; Cell Line; Genes, Viral; Hydrolases; Methionine; Methyltransferases; Mutation; S-Adenosylmethionine; Sindbis Virus; Tubercidin; Viral Plaque Assay

1988
Purification and characterization of 1-aminocyclopropane-1-carboxylate synthase from etiolated mung bean hypocotyls.
    Archives of biochemistry and biophysics, 1988, Aug-01, Volume: 264, Issue:2

    Topics: Adenine; Aminooxyacetic Acid; Benzyl Compounds; Chromatography; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Fabaceae; Hydrogen-Ion Concentration; Indoleacetic Acids; Kinetin; Lyases; Molecular Weight; Plants, Medicinal; Purines; S-Adenosylmethionine; Seeds; Thermodynamics

1988
Inhibition of antibody production by 2-chloroadenosine.
    Life sciences, 1985, Jul-22, Volume: 37, Issue:3

    Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; DNA Replication; Homocysteine; Immunosuppressive Agents; Lymphocyte Activation; Male; Methylation; Mice; S-Adenosylmethionine

1985
Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat.
    The Journal of biological chemistry, 1986, Mar-05, Volume: 261, Issue:7

    Topics: Adenine; Animals; Dithioerythritol; Half-Life; Homocysteine; Liver; Methionine; Methods; Proteins; Rats; S-Adenosylmethionine; Sulfur; Time Factors; Tissue Distribution

1986
Biosynthesis of 1-methyladenine by isolated segments of starfish ovaries.
    General and comparative endocrinology, 1985, Volume: 60, Issue:2

    Topics: Adenine; Animals; Carbon Radioisotopes; Female; In Vitro Techniques; Kinetics; Methionine; Ovary; Ribonucleoproteins; S-Adenosylmethionine; Sexual Maturation; Starfish

1985
[Influence of S-adenosylmethionine on the methylation of the RNA by dimethylnitrosamine in vivo].
    Zeitschrift fur Krebsforschung, 1970, Volume: 74, Issue:2

    Topics: Adenine; Animals; Body Weight; Carbon Isotopes; Chromatography, Ion Exchange; Female; Guanine; Hydrochloric Acid; Hydrolysis; Injections, Intravenous; Liver; Male; Methionine; Methylation; Mice; Nitrosamines; Nucleosides; Rats; RNA; S-Adenosylmethionine; Spectrophotometry; Tritium

1970
Enzymatic DNA modifications in isolated nuclei from developing sea urchin embryos.
    Experimental cell research, 1972, Volume: 72, Issue:1

    Topics: Adenine; Aminohydrolases; Animals; Carbon Isotopes; Cell Fractionation; Cell Nucleus; Chromatography, Paper; Cytosine; Cytosine Nucleotides; DNA; Electron Transport Complex IV; Formates; Guanine; Hot Temperature; Methionine; Methylation; Methyltransferases; Proteins; S-Adenosylmethionine; Sea Urchins; Thymidine; Thymine; Tritium

1972
Effects of carcinogens and other agents on histone methylation by a histone arginine methyltransferase purified from rat liver cytoplasm.
    Cancer research, 1974, Volume: 34, Issue:6

    Topics: Acridines; Adenine; Adenosine; Animals; Arginine; Azo Compounds; Carbon Radioisotopes; Carcinogens; Cytoplasm; Dimethylformamide; Ethidium; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Male; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine

1974
Adenine nucleosides in solution: stabilisation of the anti-conformation by C-5' substituents.
    European journal of biochemistry, 1974, Aug-15, Volume: 47, Issue:1

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Monophosphate; Aminohydrolases; Binding Sites; Circular Dichroism; Deuterium; Dimethyl Sulfoxide; Magnetic Resonance Spectroscopy; Molecular Conformation; Muscles; Optical Rotatory Dispersion; S-Adenosylmethionine; Solvents; Spectrophotometry, Ultraviolet

1974
Regulation of one-carbon biosynthesis and utilization in Escherichia coli.
    Journal of bacteriology, 1974, Volume: 118, Issue:3

    Topics: Adenine; Alcohol Oxidoreductases; Carbon Radioisotopes; Cell-Free System; Culture Media; Enzyme Repression; Escherichia coli; Formaldehyde; Glycine; Ligases; Methionine; Mutation; Nucleosides; Oxidoreductases; S-Adenosylmethionine; Serine; Spermidine; Tetrahydrofolates; Transferases

1974
Characterization of S-adenosylmethionine: ribosomal ribonucleic acid-adenine (N 6 -) methyltransferase of Escherichia coli strain B.
    Journal of bacteriology, 1972, Volume: 110, Issue:1

    Topics: Adenine; Adenine Nucleotides; Bacillus subtilis; Binding Sites; Calcium Phosphates; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Enzyme Induction; Escherichia coli; Gels; Magnesium; Methyltransferases; Micrococcus; Potassium; Ribosomes; RNA, Ribosomal; RNA, Transfer; S-Adenosylmethionine; Sodium; Spermine; Tritium

1972
Sai-1 mutation: saccharomyces cerevisiae: characteristics of inhibition by S-adenosylmethonine and S-adenosylhomocysteine and protection by methionine.
    Journal of bacteriology, 1972, Volume: 110, Issue:3

    Topics: Adenine; Carbon Isotopes; Cell Fractionation; Enterococcus faecalis; Genetics, Microbial; Homocysteine; Methionine; Mutation; Protein Biosynthesis; RNA; S-Adenosylmethionine; Saccharomyces; Saccharomyces cerevisiae; Uracil

1972
Deoxyribonucleic acid methylation and development in Caulobacter bacteroides.
    Journal of bacteriology, 1973, Volume: 116, Issue:1

    Topics: Adenine; Bacteria; Carbon Radioisotopes; Cell-Free System; Chromatography, Thin Layer; Cytosine; DNA, Bacterial; Hydrolysis; Methylation; Methyltransferases; S-Adenosylmethionine

1973
5'-Methylthioadenosine and related compounds as precursors of S-adenosylmethionine in yeast.
    Biochimica et biophysica acta, 1973, Sep-14, Volume: 320, Issue:2

    Topics: Adenine; Adenosine; Aerobiosis; Candida; Carbon Radioisotopes; Deoxyadenosines; Methionine; Optical Rotation; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Sulfides; Sulfur Radioisotopes; Thionucleosides; Time Factors

1973
The effects of diamines and polyamines on enzymic methylation of nucleic acid.
    Biochimica et biophysica acta, 1971, Apr-08, Volume: 232, Issue:4

    Topics: Acridines; Adenine; Amines; Animals; Biphenyl Compounds; Carbon Isotopes; Chromatography, Paper; Cytosine; Depression, Chemical; Dialysis; Escherichia coli; Guanine; Kidney; Liver; Magnesium; Male; Metabolism; Methionine; Methyltransferases; Osmolar Concentration; Phenanthridines; Polyamines; Rats; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine; Spermine; Spleen; Stimulation, Chemical; Streptomycin; Thymine; Transferases

1971
Methylation of DNA in ultraviolet-irradiated bacteria.
    Biochimica et biophysica acta, 1971, Jun-30, Volume: 240, Issue:2

    Topics: Adenine; Carbon Isotopes; Chromatography, Paper; Cytosine; Deoxyribonucleases; DNA; DNA, Bacterial; Escherichia coli; Methionine; Methylation; Methyltransferases; Nucleic Acid Denaturation; Pancreas; Radiation Effects; Ribonucleases; S-Adenosylmethionine; Time Factors; Tritium; Ultraviolet Rays; Uracil

1971
Transfer ribonucleic acid methylases during the germination of Neurospora crassa.
    Journal of bacteriology, 1971, Volume: 108, Issue:1

    Topics: Adenine; Carbon Isotopes; Cell-Free System; Chromatography, Thin Layer; Culture Media; Guanine; Hydrolysis; Methylation; Methyltransferases; Neurospora; Phenols; RNA, Transfer; S-Adenosylmethionine; Spores; Spores, Fungal

1971
[Transmethylation processes in senile involution: a working hypothesis].
    Giornale di gerontologia, 1971, Volume: 19, Issue:9

    Topics: Adenine; Aging; Arteriosclerosis; Catecholamines; DNA; Humans; Lipoproteins; Methionine; Methylation; Methyltransferases; Phosphatidylcholines; Phospholipids; RNA; S-Adenosylmethionine; Vitamin B 12

1971
Studies on acute methionine toxicity. I. Nucleolar disaggregation in guinea pig hepatic cells with methionine or ethionine and its reversal with adenine.
    The American journal of pathology, 1971, Volume: 64, Issue:2

    Topics: Adenine; Adenosine Triphosphate; Animals; Cell Nucleolus; Chromatin; Ethionine; Female; Guinea Pigs; Humans; Liver; Male; Methionine; Microscopy, Electron; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Time Factors

1971
Mutation of Saccharomyces cerevisiae preventing uptake of S-adenosylmethionine.
    Journal of bacteriology, 1971, Volume: 106, Issue:2

    Topics: Adenine; Carbon Isotopes; Colorimetry; Crosses, Genetic; Culture Media; Cysteine; Genetics, Microbial; Homocysteine; Methionine; Mutation; Nucleosides; S-Adenosylmethionine; Saccharomyces; Serine; Threonine

1971
Effect of inhibitors of transmethylation on histamine release from human basophils.
    Biochemical pharmacology, 1981, Apr-01, Volume: 30, Issue:7

    Topics: Adenine; Adenosine; Basophils; Calcimycin; Histamine Release; Homocysteine; Humans; Immunoglobulin E; In Vitro Techniques; Methylation; Ribonucleosides; S-Adenosylmethionine; Tubercidin

1981
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
    Journal of immunology (Baltimore, Md. : 1950), 1981, Volume: 127, Issue:4

    Topics: Adenine; Adenosine; Animals; Basophils; Female; Histamine Release; Homocysteine; Immunoglobulin E; Leukemia; Mast Cells; Methylation; Mice; Rabbits; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin

1981
Effect of inhibitors of methylation on early and late interferon synthesis in bovine kidney cell cultures.
    Journal of interferon research, 1981, Volume: 1, Issue:2

    Topics: Adenine; Adenosine; Animals; Cattle; Cells, Cultured; Cycloheximide; Cycloleucine; Homocysteine; Interferons; Methylation; Newcastle disease virus; Poly I-C; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine

1981
The effect of methyltransferase inhibitors on histamine release from human dispersed lung mast cells activated with anti-human IgE and calcium ionophore A23187.
    Biochemical pharmacology, 1984, Sep-15, Volume: 33, Issue:18

    Topics: Adenine; Adenosine; Antibodies, Anti-Idiotypic; Calcimycin; Histamine Release; Humans; Immunoglobulin E; Mast Cells; Membrane Lipids; Methylation; Methyltransferases; Phospholipids; Ribonucleosides; S-Adenosylmethionine; Tubercidin

1984
DNA-methylating activity of mycobacteria.
    Acta microbiologica Hungarica, 1983, Volume: 30, Issue:1

    Topics: 5-Methylcytosine; Adenine; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA, Bacterial; DNA, Viral; Kinetics; Methylation; Methyltransferases; Mycobacterium; S-Adenosylmethionine; Thymus Gland

1983
Simple separation of adenine and adenosyl-sulfur compounds by high-performance liquid chromatography.
    Journal of chromatography, 1983, Jul-15, Volume: 264, Issue:2

    Topics: Adenine; Adenosine; Animals; Chromatography, High Pressure Liquid; Deoxyadenosines; Male; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides

1983
Cellular defense mechanisms against alkylation of DNA.
    Basic life sciences, 1982, Volume: 20

    Topics: Adenine; Alkylation; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Methyltransferases; Mutation; N-Glycosyl Hydrolases; S-Adenosylmethionine

1982
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro.
    Carcinogenesis, 1982, Volume: 3, Issue:3

    Topics: Adenine; Animals; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Repair; Guanine; In Vitro Techniques; Methylation; S-Adenosylmethionine; Scintillation Counting; Spectrophotometry, Ultraviolet

1982
Effect of 9-beta-D-arabinofuranosyladenine and erythro-9-(2-hydroxy-3-nonyl) adenine on the metabolism of S-adenosylhomocysteine, S-adenosylmethionine, and adenosine in rat liver.
    Medical biology, 1982, Volume: 60, Issue:5

    Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Female; Homocysteine; Hydrolases; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Vidarabine

1982
Role of transmethylation reactions in cellular motility and phagocytosis.
    Molecular immunology, 1980, Volume: 17, Issue:2

    Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adult; Animals; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Guinea Pigs; Humans; In Vitro Techniques; Lactones; Macrophages; Methylation; Models, Biological; Monocytes; Peptides; Phagocytosis; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine

1980
[Possible regulatory role of 5'-methylthioadenosine on enzymatic methyl esterification of membrane protein].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Jun-15, Volume: 57, Issue:11

    Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein O-Methyltransferase; S-Adenosylmethionine; Thionucleosides

1981
Developmental regulation of cytokinin, spore germination inhibitor discadenine and related enzymes in Dictyostelium discoideum.
    Experimental cell research, 1980, Volume: 126, Issue:2

    Topics: Adenine; Alkyl and Aryl Transferases; Dictyostelium; Isopentenyladenosine; S-Adenosylmethionine; Transferases

1980
A mutational analysis of the two motifs common to adenine methyltransferases.
    The EMBO journal, 1994, Aug-15, Volume: 13, Issue:16

    Topics: Adenine; Amino Acid Sequence; Base Sequence; DNA; DNA Mutational Analysis; Escherichia coli; Molecular Sequence Data; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Structure-Activity Relationship

1994
Presteady state kinetics of an S-adenosylmethionine-dependent enzyme. Evidence for a unique binding orientation requirement for EcoRI DNA methyltransferase.
    The Journal of biological chemistry, 1993, May-05, Volume: 268, Issue:13

    Topics: Adenine; Base Sequence; Binding Sites; DNA; Escherichia coli; Kinetics; Methylation; Models, Molecular; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Conformation; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific)

1993
Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of the tobacco genome.
    European journal of biochemistry, 1998, Mar-15, Volume: 252, Issue:3

    Topics: Adenine; Cell Line; DNA Methylation; DNA, Plant; DNA, Ribosomal; Genome, Plant; Nicotiana; Plants, Toxic; RNA, Ribosomal, 5S; S-Adenosylhomocysteine; S-Adenosylmethionine

1998
Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats.
    Lipids, 1998, Volume: 33, Issue:3

    Topics: Adenine; Animals; Body Weight; Cholesterol; Dietary Proteins; Fatty Acids; Linoleic Acid; Lipids; Liver; Male; Methionine; Methylation; Organ Size; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Wistar; S-Adenosylmethionine

1998
Methyl donor for 1-methyladenine biosynthesis in starfish ovarian follicle cells.
    Molecular reproduction and development, 1999, Volume: 54, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Carbon Radioisotopes; Chromatography, Thin Layer; Cyclic AMP; Gonads; Kinetics; Methionine; Phosphodiesterase Inhibitors; S-Adenosylmethionine; Second Messenger Systems; Starfish

1999
RNA aptamers to S-adenosylhomocysteine: kinetic properties, divalent cation dependency, and comparison with anti-S-adenosylhomocysteine antibody.
    Biochemistry, 2000, Jun-20, Volume: 39, Issue:24

    Topics: Adenine; Antibodies, Monoclonal; Base Sequence; Binding Sites; Binding, Competitive; Biosensing Techniques; Cations, Divalent; Chromatography, Affinity; Cystathionine; Gene Library; Kinetics; Models, Molecular; Molecular Sequence Data; Molecular Structure; Nucleic Acid Conformation; Oligonucleotides; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine

2000
Molecular enzymology of the EcoRV DNA-(Adenine-N (6))-methyltransferase: kinetics of DNA binding and bending, kinetic mechanism and linear diffusion of the enzyme on DNA.
    Journal of molecular biology, 2000, Oct-13, Volume: 303, Issue:1

    Topics: 2-Aminopurine; Adenine; Base Sequence; Binding, Competitive; Catalysis; Coenzymes; Diffusion; DNA; DNA Methylation; DNA-Binding Proteins; Escherichia coli; Fluorescence; Kinetics; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thermodynamics

2000
Structure of RsrI methyltransferase, a member of the N6-adenine beta class of DNA methyltransferases.
    Nucleic acids research, 2000, Oct-15, Volume: 28, Issue:20

    Topics: Adenine; Amino Acid Sequence; Base Sequence; Binding Sites; Catalysis; Catalytic Domain; Crystallography, X-Ray; DNA; DNA Methylation; DNA-Binding Proteins; DNA-Cytosine Methylases; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Nucleotides; Protein Binding; Protein Structure, Secondary; Rhodobacter sphaeroides; S-Adenosylmethionine; Sequence Alignment; Site-Specific DNA-Methyltransferase (Adenine-Specific); Static Electricity; Structure-Activity Relationship; Substrate Specificity

2000
Substrate binding in vitro and kinetics of RsrI [N6-adenine] DNA methyltransferase.
    Nucleic acids research, 2000, Oct-15, Volume: 28, Issue:20

    Topics: Adenine; Adenosine; Binding Sites; Buffers; Carbon Radioisotopes; Catalysis; Chromatography, High Pressure Liquid; Coenzymes; DNA; DNA Methylation; DNA-Binding Proteins; Fluorescence; Kinetics; Nucleic Acid Conformation; Protein Binding; Rhodobacter sphaeroides; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Substrate Specificity; Thermodynamics

2000
A Taq attack displaces bases.
    Nature structural biology, 2001, Volume: 8, Issue:2

    Topics: Adenine; Crystallography, X-Ray; DNA; DNA Methylation; DNA-Binding Proteins; Models, Molecular; Nucleic Acid Conformation; Protein Conformation; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Thermus

2001
Structure of the N6-adenine DNA methyltransferase M.TaqI in complex with DNA and a cofactor analog.
    Nature structural biology, 2001, Volume: 8, Issue:2

    Topics: Adenine; Amino Acid Sequence; Base Pairing; Binding Sites; Catalysis; Coenzymes; Crystallography, X-Ray; DNA; DNA Methylation; Enzyme Stability; Hydrogen Bonding; Models, Molecular; Protein Conformation; Rotation; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Thermus

2001
Elevation of the adenylate pool in rat cardiomyocytes by S-adenosyl-L-methionine.
    Acta biochimica Polonica, 2000, Volume: 47, Issue:4

    Topics: Adenine; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Guanosine Triphosphate; Myocardium; NAD; NADP; Rats; Rats, Wistar; S-Adenosylmethionine; Time Factors

2000
Metabolism of 2,6-diaminopurine: S-adenosylmethionine as methyl donor for 2-methylamino-6-aminopurine synthesis.
    The Journal of biological chemistry, 1959, Volume: 234, Issue:6

    Topics: 2-Aminopurine; Adenine; Adenosine; Metabolic Networks and Pathways; Methionine; Purines; S-Adenosylmethionine

1959
Utilization of S-adenosylmethionine by micro-organisms.
    Journal of bacteriology, 1962, Volume: 83

    Topics: Adenine; Bacteria; Methionine; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfur

1962
Biosynthesis of S-adenosylmethionine by Saccharomyces cerevisiae. I. Adenine and methionine requirments.
    Journal of bacteriology, 1962, Volume: 83

    Topics: Adenine; Adenosine; Guanine; Methionine; Naphthalenes; S-Adenosylmethionine; Saccharomyces cerevisiae; Sulfonamides; Yeasts

1962
NMR regulatory analysis: determination and characterization of S-adenosyl-L-methionine in dietary supplements.
    Die Pharmazie, 2004, Volume: 59, Issue:4

    Topics: Adenine; Adenosine; Deuterium Oxide; Dietary Supplements; Magnetic Resonance Spectroscopy; Methionine; Reference Standards; S-Adenosylmethionine; Stereoisomerism; United States

2004
Bacteriophage T4Dam DNA-(adenine-N(6))-methyltransferase. Comparison of pre-steady state and single turnover methylation of 40-mer duplexes containing two (un)modified target sites.
    The Journal of biological chemistry, 2004, Nov-26, Volume: 279, Issue:48

    Topics: Adenine; Bacteriophage T4; DNA; DNA Methylation; Kinetics; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Time Factors; Tritium

2004
Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats.
    Bioscience, biotechnology, and biochemistry, 2006, Volume: 70, Issue:8

    Topics: Adenine; Animals; Cystathionine beta-Synthase; Diet; Dose-Response Relationship, Drug; Enzyme Activation; Homocysteine; Hyperhomocysteinemia; Liver; Male; Methionine; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors

2006
Dietary eritadenine suppresses guanidinoacetic Acid-induced hyperhomocysteinemia in rats.
    The Journal of nutrition, 2006, Volume: 136, Issue:11

    Topics: Adenine; Animals; Diet; Glycine; Hyperhomocysteinemia; Male; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine

2006
Transition state analogues in quorum sensing and SAM recycling.
    Nucleic acids symposium series (2004), 2008, Issue:52

    Topics: Adenine; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Head and Neck Neoplasms; Humans; Male; Mice; N-Glycosyl Hydrolases; Purine-Nucleoside Phosphorylase; Pyrrolidines; Quorum Sensing; S-Adenosylmethionine; Xenograft Model Antitumor Assays

2008
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine.
    Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5

    Topics: Adenine; Adenosylmethionine Decarboxylase; Catalytic Domain; Crystallography, X-Ray; Drug Design; Humans; Models, Molecular; Mutation; Protein Binding; Protein Conformation; S-Adenosylmethionine; Structure-Activity Relationship

2009
An enzyme-coupled continuous spectrophotometric assay for magnesium protoporphyrin IX methyltransferases.
    Analytical biochemistry, 2009, Nov-15, Volume: 394, Issue:2

    Topics: Adenine; Aminohydrolases; Biological Assay; Cyanobacteria; Escherichia coli; Hypoxanthine; Kinetics; Methyltransferases; Molecular Structure; Protoporphyrins; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry; Substrate Specificity; Synechocystis; Transformation, Bacterial

2009
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase.
    Nucleic acids research, 2010, Volume: 38, Issue:18

    Topics: Adenine; Archaeal Proteins; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Dimerization; Disulfides; Enzyme Stability; Histidine; Models, Molecular; Mutation; Pyrococcus abyssi; RNA, Transfer, Asp; S-Adenosylmethionine; tRNA Methyltransferases

2010
Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.
    Nucleic acids research, 2011, Volume: 39, Issue:5

    Topics: Adenine; Base Sequence; Escherichia coli; Escherichia coli Proteins; Humans; Kanamycin Resistance; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Footprinting; Ribosome Subunits, Small, Bacterial; RNA, Ribosomal, 16S; S-Adenosylhomocysteine; S-Adenosylmethionine

2011
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.
    The Journal of biological chemistry, 2011, Feb-11, Volume: 286, Issue:6

    Topics: Adenine; Adenosine; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyadenosines; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Purine-Nucleoside Phosphorylase; Pyrrolidines; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2011
Biochemistry. The two faces of SAM.
    Science (New York, N.Y.), 2011, Apr-29, Volume: 332, Issue:6029

    Topics: Adenine; Adenosine; Bacterial Proteins; Biocatalysis; Catalytic Domain; Chemical Phenomena; Cysteine; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; RNA, Bacterial; RNA, Ribosomal, 23S; S-Adenosylmethionine; Staphylococcus aureus

2011
High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
    Acta crystallographica. Section D, Biological crystallography, 2012, Volume: 68, Issue:Pt 3

    Topics: Adenine; Adenosine; Adenosylhomocysteinase; Crystallography, X-Ray; Deoxyadenosines; Hydrolases; Lupinus; Methylation; Models, Molecular; Molecular Conformation; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine

2012
Identification of new ligands for the methionine biosynthesis transcriptional regulator (MetJ) by FAC-MS.
    Journal of molecular microbiology and biotechnology, 2012, Volume: 22, Issue:4

    Topics: Adenine; Bacterial Proteins; Binding Sites; Chromatography, Affinity; Cloning, Molecular; Deoxyadenosines; DNA, Bacterial; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Vectors; High-Throughput Screening Assays; Ligands; Methionine; Protein Binding; Repressor Proteins; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Thionucleosides; Time Factors; Transcription, Genetic

2012
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA.
    Nucleic acids research, 2013, Volume: 41, Issue:2

    Topics: Adenine; Methylation; Methyltransferases; Mutation; Nuclear Proteins; Protein O-Methyltransferase; Ribonucleoproteins, Small Nucleolar; Ribosome Subunits, Large, Eukaryotic; RNA, Ribosomal; S-Adenosylmethionine; Saccharomyces cerevisiae Proteins; Sequence Deletion

2013
Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ.
    Nucleic acids research, 2013, Volume: 41, Issue:20

    Topics: Adenine; Adenosine Monophosphate; Amino Acid Sequence; Binding Sites; Catalytic Domain; Coenzymes; Escherichia coli; Escherichia coli Proteins; Methyltransferases; Models, Molecular; Molecular Sequence Data; RNA, Ribosomal, 23S; S-Adenosylhomocysteine; S-Adenosylmethionine; Sequence Alignment

2013
Dynamics of RNA modification by a multi-site-specific tRNA methyltransferase.
    Nucleic acids research, 2014, Volume: 42, Issue:18

    Topics: 2-Aminopurine; Adenine; Archaeal Proteins; Base Sequence; Models, Molecular; Pyrococcus abyssi; RNA, Transfer, Asp; S-Adenosylmethionine; Substrate Specificity; tRNA Methyltransferases

2014
A B
    Nature, 2017, 04-20, Volume: 544, Issue:7650

    Topics: Adenine; Adenosine Monophosphate; Bacillus megaterium; Bacterial Proteins; Biocatalysis; Coenzymes; Crystallography, X-Ray; Deoxyadenine Nucleotides; Genes, Bacterial; Models, Molecular; Multigene Family; Protein Conformation; S-Adenosylmethionine; Vitamin B 12

2017
Binding studies of a putative C. pseudotuberculosis target protein from Vitamin B
    Scientific reports, 2019, 04-23, Volume: 9, Issue:1

    Topics: Adenine; Amino Acid Sequence; Bacterial Proteins; Binding Sites; Corynebacterium pseudotuberculosis; Kinetics; Ligands; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Secondary; S-Adenosylmethionine; Spectrometry, Fluorescence; Structural Homology, Protein; Suramin; Vitamin B 12

2019
S-Adenosyl Methionine Cofactor Modifications Enhance the Biocatalytic Repertoire of Small Molecule C-Alkylation.
    Angewandte Chemie (International ed. in English), 2019, 12-02, Volume: 58, Issue:49

    Topics: Adenine; Alkylation; Amino Acid Sequence; Biocatalysis; Coenzymes; Methyltransferases; Models, Molecular; Molecular Structure; Protein Binding; S-Adenosylmethionine; Structure-Activity Relationship

2019
Restriction of S-adenosylmethionine conformational freedom by knotted protein binding sites.
    PLoS computational biology, 2020, Volume: 16, Issue:5

    Topics: Adenine; Amino Acid Motifs; Binding Sites; Computational Biology; Computer Simulation; Databases, Protein; Glycine; Magnetic Resonance Spectroscopy; Methionine Adenosyltransferase; Molecular Dynamics Simulation; Principal Component Analysis; Protein Binding; Protein Domains; Protein Folding; S-Adenosylmethionine; Solvents; Temperature; tRNA Methyltransferases; Water

2020
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase.
    European journal of medicinal chemistry, 2020, Sep-01, Volume: 201

    Topics: Adenine; Betacoronavirus; Coronavirus Infections; COVID-19; Exoribonucleases; Humans; Methylation; Methyltransferases; Molecular Docking Simulation; Nucleosides; Pandemics; Pneumonia, Viral; RNA Caps; RNA, Viral; S-Adenosylmethionine; SARS-CoV-2; Viral Nonstructural Proteins

2020
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine.
    Communications biology, 2022, 04-05, Volume: 5, Issue:1

    Topics: Adenine; Dietary Supplements; Liver; Methylation; S-Adenosylmethionine

2022
Structure, dynamics, and molecular inhibition of the Staphylococcus aureus m
    The Journal of biological chemistry, 2022, Volume: 298, Issue:6

    Topics: Adenine; Bacterial Proteins; Crystallography, X-Ray; Protein Conformation; RNA, Transfer; S-Adenosylmethionine; Staphylococcus aureus; tRNA Methyltransferases

2022
Structural basis for MTA1c-mediated DNA N6-adenine methylation.
    Nature communications, 2022, 06-07, Volume: 13, Issue:1

    Topics: Adenine; DNA; DNA Methylation; Epigenesis, Genetic; S-Adenosylmethionine; Tetrahymena thermophila

2022
Systematic Design of Adenosine Analogs as Inhibitors of a
    Journal of medicinal chemistry, 2023, 01-12, Volume: 66, Issue:1

    Topics: Adenine; Adenosine; Animals; Clostridioides difficile; DNA; Humans; Mammals; Methyltransferases; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine

2023
Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a
    ACS chemical biology, 2023, 04-21, Volume: 18, Issue:4

    Topics: Adenine; Adenosine; Clostridioides difficile; Clostridium Infections; DNA; Methyltransferases; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific)

2023
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases.
    European journal of medicinal chemistry, 2023, Aug-05, Volume: 256

    Topics: Adenine; Adenosine; Antiviral Agents; COVID-19; Humans; Methyltransferases; Pandemics; RNA, Viral; S-Adenosylmethionine; SARS-CoV-2; Viral Nonstructural Proteins

2023