adenine has been researched along with pyrroles in 64 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (20.31) | 18.7374 |
| 1990's | 6 (9.38) | 18.2507 |
| 2000's | 23 (35.94) | 29.6817 |
| 2010's | 20 (31.25) | 24.3611 |
| 2020's | 2 (3.13) | 2.80 |
| Authors | Studies |
|---|---|
| Gottikh, BP; Grokhovsky, SL; Gursky, GV; Krylov, AS; Zasedatelev, AS; Zhuze, AL | 1 |
| Grokhovskiĭ, SL; Gurskiĭ, GV; Krylov, AS; Zasedatelev, AS; Zhuze, AL | 1 |
| Grokhovskiĭ, SL; Tsimmer, K; Tumanian, VG; Zasedatelev, AS; Zhuze, AL | 1 |
| Chenon, MT; Grant, DM; Panzica, RP; Pugmire, RJ; Townsend, LB | 1 |
| Chen, RY; Ma, JL; Yang, SL; Yao, ZX; Yu, JG; Zhai, YF | 1 |
| Berger, NA; Eichhorn, GL | 1 |
| Baxter, CS; Byvoet, P | 1 |
| Fontenelle, LJ; Henderson, JF; Smith, CM; Snyder, FF | 1 |
| Hori, M; Saeki, T; Umezawa, H | 2 |
| Flosdorf, J; Marutzky, R; Peterssen-Borstel, H | 1 |
| Grunberger, D; Reich, E; Ward, DC | 1 |
| Hecht, SM | 1 |
| Suhadolnik, RJ; Uematsu, T | 1 |
| Amosova, O; Fresco, JR; George, J | 1 |
| Babenko, A; Vassort, G | 1 |
| Allen, LF; Fatima, S; Kan, H; Malik, KU; Parmentier, JH; Ruan, Y | 1 |
| de Koster, BM; Elferink, JG | 1 |
| Bergstrom, DE; Glass, GA; Hua, P; Kinsey, BM; Klysik, J; Orson, FM; Ward, B | 1 |
| Baird, EE; Bremer, RE; Dervan, PB; Kielkopf, CL; Rees, DC; Szewczyk, JW; Turner, JM; White, S | 1 |
| Dick, JM; Lefebvre, RA | 1 |
| Fukao, M; Horowitz, B; Keef, KD; Kenyon, JL; Mason, HS | 1 |
| Dervan, PB; Herman, DM; Melander, C | 1 |
| Birke, R; Lombardi, J; Vivoni, A | 1 |
| Boger, DL; Hedrick, MP; Stauffer, F | 1 |
| Bando, T; Sugiyama, H; Takahashi, R | 1 |
| De Godoy, M; Li, F; Rattan, S | 1 |
| Evans, GB; Furneaux, RH; Schramm, VL; Singh, V; Tyler, PC | 1 |
| Bando, T; Narita, A; Sasaki, S; Sugiyama, H | 1 |
| Carloni, P; Rothlisberger, U; Spiegel, K | 1 |
| Bando, T; Minoshima, M; Sakakibara, Y; Sasaki, S; Shinohara, K; Sugiyama, H | 1 |
| Bruice, TC; Canzio, D; Correa, BJ; Kahane, AL; Reddy, PM | 1 |
| Bertone, C; Petricca, S; Rossi, F; Santiemma, V | 1 |
| Boger, DL; Hwang, I; Kastrinsky, DB; Shiga, F; Tichenor, MS; Trzupek, JD | 1 |
| Engels, JW; Mu, Y; Piton, N; Prisner, TF; Schiemann, O; Stock, G | 1 |
| Earm, YE; Han, J; Jung, ID; Kang, SH; Kim, N; Ko, JH; Park, WS; Park, YM; Son, YK; Warda, M | 1 |
| Galasso, V; Pichierri, F | 1 |
| Asao, T; Hartley, JA; Kiakos, K; Lee, M; McHugh, PJ; Sato, A | 1 |
| Lu, CC; Tsai, SC | 1 |
| Delso, I; Merino, P; Tejero, T | 1 |
| Ahn, Y; Holz, O; Kamio, K; Kawasaki, S; Kobayashi, T; Liu, X; Magnussen, H; Mao, L; Rennard, SI; Sato, T; Sugiura, H; Togo, S; Wang, X | 1 |
| Bertone, C; Bianco, MJ; Brama, M; Castelli, A; Rossi, F; Santiemma, V | 1 |
| Harbord, N | 1 |
| Al-Hashimi, HM; Brooks, CL; Eichhorn, CD; Feng, J; Suddala, KC; Walter, NG | 1 |
| de Serres, M; Gould, E; Johnson, M; Kim, J; Lou, Y; Mayers, D; Pietropaolo, K; Piscitelli, S; White, S; Zhou, XJ | 1 |
| Atkins, C; Axten, JM; Feng, Y; Gampe, RT; Goetz, A; Grant, SW; Hassell, AM; Heerding, DA; Hong, X; Kahler, KM; Kumar, R; Li, WH; Liu, Q; Medina, JR; Mencken, T; Minthorn, E; Rabindran, S; Romeril, SP; Shewchuk, LM; Shu, A; Sigethy, SD; Stanley, T; Taylor, JD; Tomberlin, GH | 1 |
| Lamoureux, F; Zoubeidi, A | 1 |
| Bhang, HE; Chan, FC; Cooke, VG; Derti, A; Dietze, K; Dörken, B; Farsidjani, A; Frick, M; Fritsch, C; Gascoyne, RD; Hummel, M; Kauffmann, A; Kim, S; Korn, JM; Kovats, S; Kridel, R; Lenz, G; Meissner, B; Monahan, J; Morrissey, MP; Naylor, T; Pfister, E; Rahal, R; Rakiec, D; Romero, R; Ruddy, D; Sellers, WR; Stegmeier, F; Steidl, C; Tzankov, A | 1 |
| Gao, YS; Lu, LM; Nie, T; Wu, LP; Wu, Y; Xu, JK; Zhang, KX; Zhu, XF | 1 |
| Cheng, S; Coleman, M; Guo, A; Lu, P; Ma, J; Wang, YL | 1 |
| Bekerman, E; Einav, S | 1 |
| Clinch, K; Evans, GB; Freitas, EO; Guan, R; Meyer-Fernandes, JR; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC | 1 |
| Ott, G; Rauert-Wunderlich, H; Rosenwald, A; Rudelius, M | 1 |
| Andrews, DW; Brauer, PM; Hariharan, S; Leber, B; Oakes, CC; Oppermann, S; Shi, Y; Spaner, DE; Ylanko, J; Zúñiga-Pflücker, JC | 1 |
| Bartolotti, LJ; Bourdelais, AJ; Buchanan, MK; Chauvigne-Hines, LM; Frampton, AR; Goodwin, TJ; Kelly, CB; Mastro-Kishton, K; McIver, AL; Needham, CN; Neill, NE; Varadarajan, S; White, MC | 1 |
| Diao, Y; Gao, N; Jiang, W; Jin, G; Jin, Z; Li, W; Liu, Y; Wang, X; Wang, Z; Zhong, J | 1 |
| Li, W; Lin, Y; Liu, R; Ma, J; Shao, N; Shi, Y; Wang, S; Wu, W | 1 |
| Barry, ST; Berdel, WE; Cruzalegui, F; Dai, B; Davies, BR; Erdmann, K; Erdmann, T; Grau, M; Grondine, M; Hudson, K; Klener, P; Lenz, G; Lenz, P; Lynch, JT; Mayo, M; Molinsky, J; Ott, G; Pfeifer, M; Polanska, UM; Schwammbach, D; Staiger, AM; Trneny, M; Tuskova, D; Vočková, P; Zapukhlyak, M | 1 |
| Bae, H; Bang, H; Choi, J; Kim, JH; Kim, T; Kim, YW; Ko, JH; Lee, D; Lim, I | 1 |
| Bae, J; Jo, K; Kawamoto, Y; Kim-Ha, J; Lee, S; Park, J; Sugiyama, H; Vaijayanthi, T | 1 |
| Cheng, F; Li, J; Li, XM; Tan, GS; Xu, KP; Xu, PS; Yao, CP; Zhang, Y; Zhou, G; Zou, ZX | 1 |
| Furukawa, S; Ishikawa, T; Kikuchi, H; Ooka, A; Saito, SY; Yamaguchi, M | 1 |
| Bandyopadhyay, T; Ganguly, B; Ghosh, S; Jana, K; Wakchaure, PD | 1 |
| Ashelford, K; Corcoran, DB; Fegan, CD; Giles, PJ; Lewis, T; Miraz Rahman, K; Pepper, AGS; Pepper, C; Thurston, DE; Walsby, EJ | 1 |
2 review(s) available for adenine and pyrroles
| Article | Year |
|---|---|
Current developments in the synthesis and biological activity of aza-C-nucleosides: immucillins and related compounds.
Topics: Adenine; Adenosine; Aza Compounds; Glycoside Hydrolases; N-Glycosyl Hydrolases; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines | 2008 |
Novel nephrotoxins.
Topics: Adenine; Alcohols; Angiogenesis Inhibitors; Anticonvulsants; Antipsychotic Agents; Dasatinib; Diphosphonates; Glutamates; Guanine; HIV Protease Inhibitors; Humans; Indoles; Kidney Diseases; Organophosphonates; Oxalates; Pamidronate; Pemetrexed; Phenindione; Plants, Toxic; Proton Pump Inhibitors; Pyrimidines; Pyrroles; Selective Serotonin Reuptake Inhibitors; Sunitinib; Tenofovir; Thiazoles; Triazines | 2011 |
1 trial(s) available for adenine and pyrroles
| Article | Year |
|---|---|
Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
Topics: Adenine; Androstenes; Anti-HIV Agents; Atazanavir Sulfate; Atorvastatin; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Darunavir; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Interactions; Emtricitabine; Ethinyl Estradiol; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Least-Squares Analysis; Linear Models; Lopinavir; Male; Oligopeptides; Organophosphonates; Patient Safety; Phosphinic Acids; Pyridines; Pyrimidines; Pyrroles; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Risk Assessment; Ritonavir; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Tenofovir | 2012 |
61 other study(ies) available for adenine and pyrroles
| Article | Year |
|---|---|
Quantitative estimation of the contribution of pyrrolcarboxamide groups of the antibiotic distamycin A into specificity of its binding to DNA AT pairs.
Topics: Adenine; Chemical Phenomena; Chemistry; Circular Dichroism; Dansyl Compounds; Distamycins; DNA; Ligands; Nucleic Acid Conformation; Polydeoxyribonucleotides; Proline; Pyrroles; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics; Thymine | 1979 |
[Quantitative assessment of the contribution of the pyrrolcarboxamide groups in distamycin A antibiotic in achieving its binding specificity with DNA AT-pairs].
Topics: Adenine; Adsorption; Dansyl Compounds; Distamycins; DNA; Proline; Protein Binding; Pyrroles; Spectrometry, Fluorescence; Structure-Activity Relationship; Thymine | 1978 |
[Stereochemical model of the molecular mechanism of the "recognition" of AT-pairs during the binding with DNA of the antibiotics distamycin A and netropsin].
Topics: Adenine; Anti-Bacterial Agents; Base Sequence; Distamycins; DNA; Guanidines; Models, Chemical; Netropsin; Pyrroles; Thymine | 1976 |
Carbon-13 magnetic resonance. XXV. A basic set of parameters for the investigation of tautomerism im purines. Established from carbon-13 magnetic resonance studies using certain purines and pyrrolo[2,3-d]pyrimidines.
Topics: Adenine; Hypoxanthines; Magnetic Resonance Spectroscopy; Mercaptopurine; Purines; Pyrimidines; Pyrroles | 1975 |
[Studies on constituents of ganoderma capense IV. The chemical structures of ganoine, ganodine and ganoderpurine].
Topics: Adenine; Alkaloids; Drugs, Chinese Herbal; Polyporaceae; Pyrroles | 1990 |
Interaction of metal ions with polynucleotides and related compounds. XIV. Nuclear magnetic resonance studies of the binding of copper(II) to adenine nucleotides.
Topics: Adenine; Adenine Nucleotides; Binding Sites; Chelating Agents; Chemical Phenomena; Chemistry; Copper; Cyclic AMP; Deuterium; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Structural; Nucleosides; Phosphoric Acids; Polynucleotides; Protons; Pyrimidines; Pyrroles; Ribonucleosides; Ribose | 1971 |
Effects of carcinogens and other agents on histone methylation by a histone arginine methyltransferase purified from rat liver cytoplasm.
Topics: Acridines; Adenine; Adenosine; Animals; Arginine; Azo Compounds; Carbon Radioisotopes; Carcinogens; Cytoplasm; Dimethylformamide; Ethidium; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Male; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Improved methods for the study of drug effects on purine metabolism and their application to nebularine and 7-deazanebularine.
Topics: Adenine; Animals; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, DEAE-Cellulose; Diphosphates; Fibroblasts; Guanine; Hypoxanthines; Inosine; Kinetics; Nucleotides; Oxidoreductases; Purine Nucleosides; Purines; Pyrimidines; Pyrroles; Ribonucleosides; Stimulation, Chemical; Structure-Activity Relationship | 1974 |
Kinetic studies on the inhibition of nucleoside diphosphate kinase by desdanine.
Topics: Acrylamides; Adenine; Adenosine Triphosphate; Anti-Bacterial Agents; Carbon Radioisotopes; Chromatography, Gel; DNA, Bacterial; Escherichia coli; Isoelectric Focusing; Kinetics; Molecular Weight; Phosphotransferases; Pyrroles; Ribonucleotides; RNA, Bacterial; Sonication; Temperature; Thymine Nucleotides; Time Factors | 1974 |
Large scale enzymatic synthesis of nucleoside-5'-monophosphates using a phosphotransferase from carrots.
Topics: Adenine; Aza Compounds; Chromatography, DEAE-Cellulose; Chromatography, Gel; Deoxyadenosines; Mercaptopurine; Nitrophenols; Nucleosides; Nucleotides; Oxidative Phosphorylation; Phosphates; Phosphoric Monoester Hydrolases; Phosphotransferases; Plants, Edible; Purine Nucleosides; Pyrimidines; Pyrroles; Ribonucleosides; Vegetables | 1974 |
7-Deazanebularin. Coding properties of triplets and polynucleotides.
Topics: Adenine; Adenine Nucleotides; Amino Acids; Arginine; Carbon Isotopes; Centrifugation, Density Gradient; Escherichia coli; Genetic Code; Lysine; Nucleosides; Peptide Biosynthesis; Polynucleotides; Pyrimidines; Pyrroles; Ribonucleotides; Ribosomes; RNA, Transfer; Tritium | 1972 |
Cyclamidomycin (desdanine), an inhibitor of nucleoside diphosphokinase of Escherichia coli.
Topics: Acrylamides; Adenine; Anti-Bacterial Agents; Carbon Isotopes; Depression, Chemical; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Glucosamine; Isoleucine; Nucleosides; Phosphotransferases; Pyrroles; RNA, Bacterial | 1972 |
Mass spectra of some heterocycles related to N 6 -( 2 -isopentenyl)adenosine.
Topics: Adenine; Adenosine; Alkenes; Mass Spectrometry; Methylation; Nucleosides; Pyrazoles; Pyrimidines; Pyrroles; Sulfides | 1971 |
Nucleoside antibiotics. VI. Biosynthesis of the pyrrolopyrimidine nucleoside antibiotic toyocamycin by Streptomyces rimosus.
Topics: Adenine; Anti-Bacterial Agents; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Formates; Guanine; Nucleosides; Pyrimidines; Pyrroles; Streptomyces | 1970 |
Effect of the 1-(2'-deoxy-beta-D-ribofuranosyl)-3-nitropyrrole residue on the stability of DNA duplexes and triplexes.
Topics: Adenine; Base Composition; Base Sequence; Calorimetry; Cytosine; Deoxyribonucleosides; DNA; Guanine; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Pyrroles; Structure-Activity Relationship; Thermodynamics; Thymine | 1997 |
Enhancement of the ATP-sensitive K+ current by extracellular ATP in rat ventricular myocytes. Involvement of adenylyl cyclase-induced subsarcolemmal ATP depletion.
Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Animals; Benzopyrans; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Colforsin; Cromakalim; Deoxyadenine Nucleotides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; GTP-Binding Proteins; Guanidines; Guanosine Triphosphate; Heart Ventricles; Male; Patch-Clamp Techniques; Peptide Fragments; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Wistar; Uncoupling Agents | 1997 |
Alpha-1A adrenergic receptor stimulation with phenylephrine promotes arachidonic acid release by activation of phospholipase D in rat-1 fibroblasts: inhibition by protein kinase A.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Arachidonic Acid; Calcimycin; Carbazoles; Cell Line; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Enzyme Activation; Enzyme Inhibitors; Glycerides; GTP-Binding Proteins; Indoles; Lipase; Phenylephrine; Phospholipase D; Phospholipases A; Phospholipases A2; Prazosin; Pyrroles; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Transfection; Virulence Factors, Bordetella | 1998 |
The role of cyclic AMP and protein kinase A in stimulation of neutrophil migration by endothelins.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Carbazoles; Cell Movement; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; Enzyme Inhibitors; Humans; Imines; Indoles; Neutrophils; Pyrroles; Thionucleotides | 1998 |
Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interruptions in a polypurine target.
Topics: Acridines; Adenine; Gene Expression Regulation; Genetic Techniques; Guanine; Intercalating Agents; Kinetics; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Purines; Pyrimidines; Pyrroles | 1999 |
Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove.
Topics: Adenine; Base Sequence; Dimerization; DNA; Hydrogen Bonding; Models, Molecular; Nucleic Acid Conformation; Nylons; Pyrroles; Thymine | 2000 |
Interplay between nitric oxide and vasoactive intestinal polypeptide in the pig gastric fundus smooth muscle.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Isoquinolines; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Sulfonamides; Swine; Thionucleotides; Vasoactive Intestinal Peptide | 2000 |
Regulation of BK(Ca) channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid.
Topics: 8,11,14-Eicosatrienoic Acid; Adenine; ADP Ribose Transferases; Antibodies; Carbazoles; Cells, Cultured; Drug Interactions; Electrophysiology; Enzyme Inhibitors; Gene Expression Regulation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Humans; Indoles; Kidney; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Large-Conductance Calcium-Activated Potassium Channel beta Subunits; Large-Conductance Calcium-Activated Potassium Channels; Potassium Channels; Potassium Channels, Calcium-Activated; Pyrroles | 2001 |
Discrimination of A/T sequences in the minor groove of DNA within a cyclic polyamide motif.
Topics: Adenine; Base Sequence; DNA; DNA, Circular; Molecular Sequence Data; Nucleic Acid Conformation; Nylons; Pyrroles; Sequence Analysis, DNA; Substrate Specificity; Thymine | 2000 |
Optimization of force constants with an Urey-Bradley force field avoiding normal mode crossings.
Topics: Adenine; Aniline Compounds; Benzene; Chemical Phenomena; Chemistry, Physical; Heterocyclic Compounds; Imidazoles; Models, Chemical; Molecular Structure; Organic Chemicals; Pyridines; Pyrimidines; Pyrroles; Software | 2001 |
Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.
Topics: Adenine; Alkylation; Antibiotics, Antineoplastic; Binding Sites; DNA; DNA Adducts; Duocarmycins; Humans; Indoles; Inhibitory Concentration 50; Leucomycins; Nucleic Acid Conformation; Pyrroles; Pyrrolidinones; Tumor Cells, Cultured | 2001 |
Specific alkylation of human telomere repeats by hairpin pyrrole-imidazole polyamide.
Topics: Adenine; Alkylation; Antineoplastic Agents, Alkylating; Cell Division; Cell Line, Tumor; DNA; Humans; Imidazoles; Inhibitory Concentration 50; Nucleic Acid Conformation; Nylons; Oligonucleotides; Pyrroles; Repetitive Sequences, Nucleic Acid; Telomere | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase.
Topics: Adenine; Humans; Polyamines; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines; Stereoisomerism; Structure-Activity Relationship | 2004 |
Specific adenine alkylation by pyrrole-imidazole CBI conjugates.
Topics: Adenine; Alkylation; Crystallography, X-Ray; Cyclopropanes; Imidazoles; Indoles; Models, Molecular; Molecular Structure; Nylons; Pyrroles | 2005 |
Duocarmycins binding to DNA investigated by molecular simulation.
Topics: Adenine; Algorithms; Alkylation; Antineoplastic Agents, Alkylating; Base Sequence; Binding Sites; Catalysis; Computer Simulation; DNA; Duocarmycins; Hydrogen Bonding; Indoles; Molecular Conformation; Oligonucleotides; Pyrroles | 2006 |
Antitumor activity of sequence-specific alkylating agents: pyrolle-imidazole CBI conjugates with indole linker.
Topics: Adenine; Alkylation; Animals; Antineoplastic Agents, Alkylating; Base Sequence; Cell Line, Tumor; Cyclopropanes; Humans; Imidazoles; Indoles; Models, Molecular; Molecular Sequence Data; Molecular Structure; Neoplasms; Nucleic Acid Conformation; Nylons; Polymerase Chain Reaction; Pyrroles; Thymine | 2006 |
DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides.
Topics: Adenine; Base Pairing; Base Sequence; Bisbenzimidazole; Cytosine; DNA; Guanine; Imidazoles; Molecular Sequence Data; Nylons; Peptides; Pyrroles; Temperature; Thymine | 2006 |
Ghrelin inhibits angiotensin II-induced migration of human aortic endothelial cells.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Angiotensin II; Aorta; Carbazoles; Cell Movement; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Ghrelin; Humans; Indoles; Oligopeptides; Peptide Hormones; Proto-Oncogene Proteins c-akt; Pyrroles | 2007 |
Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.
Topics: Adenine; Alkylating Agents; Alkylation; Antibiotics, Antineoplastic; Base Pairing; Base Sequence; DNA; Duocarmycins; Hydrogen-Ion Concentration; Indoles; Kinetics; Models, Chemical; Pyrroles; Stereoisomerism; Streptomyces; Temperature | 2006 |
Base-specific spin-labeling of RNA for structure determination.
Topics: Adenine; Computer Simulation; Cyclic N-Oxides; Cytosine; Electron Spin Resonance Spectroscopy; Oligoribonucleotides; Organophosphorus Compounds; Pyrroles; RNA; Spin Labels | 2007 |
Acute hypoxia induces vasodilation and increases coronary blood flow by activating inward rectifier K(+) channels.
Topics: Acute Disease; Adenine; Animals; Blood Pressure; Carbazoles; Coronary Circulation; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Glyburide; Hypoxia; In Vitro Techniques; Indoles; Male; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyrroles; Rabbits; Signal Transduction; Thionucleotides; Vasodilation | 2007 |
DFT study of conformational and spectroscopic properties of yatakemycin.
Topics: Adenine; Duocarmycins; Electrons; Indoles; Models, Molecular; Molecular Conformation; Oxygen; Protons; Pyrroles; Solutions; Spectrum Analysis; Vibration; Water | 2007 |
DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
Topics: Adenine; Alkylating Agents; Alkylation; Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cricetulus; DNA Adducts; DNA Damage; DNA Repair; Drug Evaluation, Preclinical; Duocarmycins; Humans; Indoles; Mice; Molecular Structure; Pyrroles; Saccharomyces cerevisiae; Structure-Activity Relationship; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
The cyclic AMP-dependent protein kinase A pathway is involved in progesterone effects on calcitonin secretion from TT cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Blotting, Western; Calcitonin; Carbazoles; Cell Line, Tumor; Cell Nucleus; CREB-Binding Protein; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique; Gene Expression; Humans; Indoles; Mifepristone; Progesterone; Progestins; Pyrroles; Receptors, Progesterone; RNA, Messenger; Signal Transduction; Time Factors | 2007 |
Prostacyclin analogs stimulate VEGF production from human lung fibroblasts in culture.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adult; Carbazoles; Cell Culture Techniques; Cells, Cultured; Epoprostenol; Fibroblasts; Humans; Iloprost; Lung; Prostaglandins I; Pyrroles; RNA, Messenger; Stimulation, Chemical; Vascular Endothelial Growth Factor A | 2008 |
Ghrelin induces proliferation in human aortic endothelial cells via ERK1/2 and PI3K/Akt activation.
Topics: Adenine; Androstadienes; Aorta; Carbazoles; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Flavonoids; Ghrelin; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrroles; Wortmannin | 2008 |
Unraveling the structural complexity in a single-stranded RNA tail: implications for efficient ligand binding in the prequeuosine riboswitch.
Topics: Adenine; Ligands; Molecular Dynamics Simulation; Mutation; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch; RNA; RNA Stability | 2012 |
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
Topics: Adenine; Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Crystallography, X-Ray; Dogs; Drug Screening Assays, Antitumor; eIF-2 Kinase; Female; Humans; Indoles; Male; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Phosphorylation; Protein Conformation; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Transplantation, Heterologous | 2012 |
Dual inhibition of autophagy and the AKT pathway in prostate cancer.
Topics: Adenine; Autophagy; Cell Line, Tumor; Chloroquine; Clinical Trials, Phase I as Topic; Humans; Macrolides; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
Pharmacological and genomic profiling identifies NF-κB-targeted treatment strategies for mantle cell lymphoma.
Topics: Adenine; Baculoviral IAP Repeat-Containing 3 Protein; Base Sequence; Blotting, Western; CARD Signaling Adaptor Proteins; Cell Line; Cell Survival; DNA Primers; Guanylate Cyclase; Humans; Inhibitor of Apoptosis Proteins; Luminescent Measurements; Lymphoma, Mantle-Cell; Microarray Analysis; Molecular Sequence Data; NF-kappa B; NF-kappaB-Inducing Kinase; Piperidines; Protein Serine-Threonine Kinases; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Real-Time Polymerase Chain Reaction; Receptors, Antigen, B-Cell; RNA Interference; Sequence Analysis, RNA; Signal Transduction; TNF Receptor-Associated Factor 2; TNF Receptor-Associated Factor 3; Trypan Blue; Ubiquitin-Protein Ligases | 2014 |
Overoxidized polypyrrole/graphene nanocomposite with good electrochemical performance as novel electrode material for the detection of adenine and guanine.
Topics: Adenine; Animals; Biosensing Techniques; Cattle; DNA; Electrochemical Techniques; Electrodes; Graphite; Guanine; Hydrogen-Ion Concentration; Limit of Detection; Microscopy, Electron, Scanning; Nanocomposites; Oxidation-Reduction; Polymers; Pyrroles; Reproducibility of Results; Spectroscopy, Fourier Transform Infrared | 2014 |
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclohexylamines; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; Thiazoles | 2015 |
Infectious disease. Combating emerging viral threats.
Topics: Adenine; Adenosine; Antiviral Agents; Benzamides; Chloroquine; Communicable Diseases, Emerging; Cyclosporins; Cytosine; Dengue; Drug Approval; Drug Design; Erlotinib Hydrochloride; Hemorrhagic Fever, Ebola; Humans; Imatinib Mesylate; Indoles; Organophosphonates; Piperazines; Purine Nucleosides; Pyrimidines; Pyrroles; Pyrrolidines; Quinazolines; Sunitinib; Viruses | 2015 |
Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro.
Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Cell Proliferation; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Pyrrolidines | 2015 |
Targeting protein kinase C in mantle cell lymphoma.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; Cell Death; Drug Resistance, Neoplasm; Humans; Lymphoma, Mantle-Cell; MAP Kinase Signaling System; Molecular Targeted Therapy; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; Quinazolines; Tumor Cells, Cultured | 2016 |
High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.
Topics: Adenine; bcl-X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cellular Microenvironment; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Imaging, Three-Dimensional; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mutation; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyrimidines; Pyrroles; Quinazolinones; Reproducibility of Results; Signal Transduction; Stromal Cells; Sulfonamides; Sunitinib; Up-Regulation | 2016 |
Glycoconjugated Site-Selective DNA-Methylating Agent Targeting Glucose Transporters on Glioma Cells.
Topics: Adenine; Alkanesulfonates; Antineoplastic Agents, Alkylating; Biological Transport; Cell Line, Tumor; Cell Survival; DNA Adducts; DNA Damage; DNA Methylation; DNA, Neoplasm; Gene Expression; Glucosamine; Glucose Transport Proteins, Facilitative; Glycoconjugates; Humans; Molecular Dynamics Simulation; Molecular Targeted Therapy; Neuroglia; Nucleic Acid Conformation; Pyrroles; Streptozocin | 2017 |
Immunomodulatory and Antitumor Effects of a Novel TLR7 Agonist Combined with Lapatinib.
Topics: Adenine; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line; Dendritic Cells; Female; Immunotherapy; Indoles; Lapatinib; Lymphocytes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrroles; Quinazolines; Spleen; Succinates; Sunitinib; Toll-Like Receptor 7 | 2016 |
Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase Cell Cycle Checkpoints; Humans; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; Triple Negative Breast Neoplasms | 2017 |
Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Animals; Antineoplastic Agents; Apoptosis; Drug Combinations; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Large B-Cell, Diffuse; Mice; NF-kappa B; Organ Specificity; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; PTEN Phosphohydrolase; Pyrazoles; Pyrimidines; Pyrroles; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Effects of Nitric Oxide on Voltage-Gated K⁺ Currents in Human Cardiac Fibroblasts through the Protein Kinase G and Protein Kinase A Pathways but Not through S-Nitrosylation.
Topics: Action Potentials; Adenine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Myofibroblasts; Nitric Oxide; Oxadiazoles; Potassium Channels, Voltage-Gated; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2018 |
TAMRA-polypyrrole for A/T sequence visualization on DNA molecules.
Topics: Adenine; Base Pairing; Base Sequence; Benzoxazoles; DNA; Escherichia coli; Fluorescent Dyes; Intercalating Agents; Polymers; Pyrroles; Quinolinium Compounds; Rhodamines; Single Molecule Imaging; Staining and Labeling; Thymine | 2018 |
New adenine analogues and a pyrrole alkaloid from
Topics: Adenine; Alkaloids; Antigens, Viral; Antiviral Agents; Circular Dichroism; DNA, Viral; Hepatitis B virus; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Pyrroles; Selaginellaceae | 2019 |
Differentiation-inducing factor-1 prevents hepatic stellate cell activation through inhibiting GSK3β inactivation.
Topics: Active Transport, Cell Nucleus; Adenine; Animals; Antineoplastic Agents; beta Catenin; Cell Differentiation; Cell Transdifferentiation; Dictyostelium; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Hepatic Stellate Cells; Hexanones; Liver Cirrhosis; Mice; Oxadiazoles; Phosphorylation; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction | 2019 |
Quantum chemical and well-tempered metadynamics study to design adenine analogs for orthogonal Preq
Topics: Adenine; Nucleic Acid Conformation; Pyrimidinones; Pyrroles; Riboswitch | 2020 |
Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers.
Topics: Adenine; Animals; Apoptosis; Benzodiazepines; Bortezomib; Hematologic Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Inbred NOD; Mice, SCID; NF-kappa B; Piperidines; Pyrroles; Tumor Microenvironment | 2021 |