Compounds > adenine

adenine and purvalanol b

adenine has been researched along with purvalanol b in 16 studies

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's10 (62.50)29.6817
2010's4 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, G; Espinoza, FH; Gray, NS; Kim, SH; Kwon, S; LeClerc, S; Lockhart, DJ; Meijer, L; Morgan, DO; Norman, TC; Schultz, PG; Thunnissen, AM; Wodicka, L1
Chang, YT; Gray, NS; Kwon, S; Leost, M; Meijer, L; Norman, TC; Rosania, GR; Sarohia, R; Schultz, PG; Sutherlin, DP1
Doerig, C; Gray, N; Harmse, L; Havlik, I; Leclerc, S; Meijer, L; Schultz, P; van Zyl, R1
Adachi, S; Han, Z; Obaya, AJ; Ramos-Desimone, N; Sedivy, JM; Wyche, JH1
Bouget, FY; Brownlee, C; Corellou, F; Kloareg, B1
Bantly, A; Gray, NS; Knockaert, M; Malim, MH; Meijer, L; Schaffer, PA; Schang, LM; Shaheen, F1
Gray, N; Knockaert, M; Lenormand, P; Meijer, L; Pouysségur, J; Schultz, P1
Baumann, S; Becker, F; Bockovich, N; Come, J; Costa-Roldán, N; Dedier, S; Degenhart, C; Dill, S; Hanke, U; Hediger, M; Huber, A; Kaufmann, C; Kinsman, D; Kley, N; Kluge, AF; Meier-Ewert, S; Murthi, K; Smith, C; Wallner, W1
Donald, RG; Liberator, PA; Meijer, L; Zhong, T1
Adams, S; Andrade, L; Bohacek, R; Dalgarno, D; Grossman, T; Jin, L; Keats, J; Keenan, T; MacNeil, I; Metcalf, C; Narula, S; Ram, M; Sawyer, T; Schelling, P; Shakespeare, W; Stehle, T; Sundaramoorthi, R; van Schravendijk, MR; Wang, Y; Weigele, M1
Aleem, E; Kaldis, P; Megyesi, J; Nowak, G; Price, PM; Safirstein, RL; Yu, F1
Sera, T1
Becker, F; Brock, R; Chung, YD; Glauner, H; Hannus, S; Hansen, K; Ruttekolk, IR; Steemers, B1
Albanese, C; Das, S; Fricke, ST; Karam, S; Lee, YC; Lisanti, MP; Moasser, B; Ozcan, A; Petricoin, E; Pishvaian, M; Ringer, L; Rodriguez, OC; Rood, B; Salinas, P; Schlegel, R; Sirajuddin, P; Sivakumar, A; Üren, A; Wang, SS; Wang, Y; Yenugonda, V1
Broccardo, C; Bullard, KM; Keenan, SM1
Arisan, ED; Coker-Gurkan, A; Obakan-Yerlikaya, P; Ozfiliz-Kilbas, P; Palavan-Unsal, N; Sarikaya, B; Temizci, B1

Reviews

1 review(s) available for adenine and purvalanol b

ArticleYear
[Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].
    Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2007, Volume: 52, Issue:13 Suppl

    Topics: Adenine; Cell Division; Cyclin-Dependent Kinases; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Genomics; Humans; Kinetin; Ligands; Microarray Analysis; Small Molecule Libraries; Tumor Cells, Cultured

2007

Other Studies

15 other study(ies) available for adenine and purvalanol b

ArticleYear
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
    Science (New York, N.Y.), 1998, Jul-24, Volume: 281, Issue:5376

    Topics: Adenine; Binding Sites; CDC2-CDC28 Kinases; CDC28 Protein Kinase, S cerevisiae; Cell Division; Crystallography, X-Ray; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation, Fungal; Genes, Fungal; Humans; Hydrogen Bonding; Oligonucleotide Probes; Phosphates; Piperidines; Protein Serine-Threonine Kinases; Purines; RNA, Messenger; Saccharomyces cerevisiae; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured

1998
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
    Chemistry & biology, 1999, Volume: 6, Issue:6

    Topics: Adenine; Binding Sites; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cyclin A; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Protein Conformation; Purines; Structure-Activity Relationship; Tumor Cells, Cultured

1999
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.
    Biochemical pharmacology, 2001, Aug-01, Volume: 62, Issue:3

    Topics: Adenine; Animals; Antimalarials; Cell Cycle; Dose-Response Relationship, Drug; Isopentenyladenosine; Kinetin; Parasitic Sensitivity Tests; Phosphotransferases; Plasmodium falciparum; Purines; Roscovitine; Structure-Activity Relationship

2001
c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle.
    Molecular and cellular biology, 2001, Volume: 21, Issue:15

    Topics: Adenine; Animals; Apoptosis; CDC2-CDC28 Kinases; Cell Line; Cisplatin; Cross-Linking Reagents; Cyclin A; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Etoposide; Flow Cytometry; G1 Phase; G2 Phase; Immunoblotting; Kinetics; Mutagenesis, Site-Directed; Nucleic Acid Synthesis Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Rats; Recombination, Genetic; Time Factors; Transgenes

2001
Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote.
    Development (Cambridge, England), 2001, Volume: 128, Issue:21

    Topics: Adenine; Algal Proteins; Aphidicolin; Cell Cycle; Cell Polarity; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Kinetin; Microinjections; Phaeophyceae; Purines; Zygote

2001
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins.
    Journal of virology, 2002, Volume: 76, Issue:15

    Topics: Adenine; Animals; Antiviral Agents; Cell Cycle; Cell Line; Chlorocebus aethiops; Cyclin-Dependent Kinases; Drug Resistance, Viral; Enzyme Inhibitors; HIV-1; Humans; Purines; Roscovitine; Simplexvirus; Vero Cells; Viral Proteins; Virus Replication

2002
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
    Oncogene, 2002, Sep-19, Volume: 21, Issue:42

    Topics: Adenine; Animals; Blotting, Western; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Cricetinae; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Structure; Nucleolin; Phosphoproteins; Phosphorylation; RNA-Binding Proteins; Transfection

2002
A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors.
    Chemistry & biology, 2004, Volume: 11, Issue:2

    Topics: Adenine; Animals; Binding Sites; CDC2 Protein Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Ligands; Protein Array Analysis; Proteome; Saccharomyces; Two-Hybrid System Techniques

2004
Characterization of two T. gondii CK1 isoforms.
    Molecular and biochemical parasitology, 2005, Volume: 141, Issue:1

    Topics: Adenine; Amino Acid Sequence; Animals; Antiprotozoal Agents; Blotting, Western; Casein Kinase I; Casein Kinase Ialpha; Cell Membrane; Cloning, Molecular; Cytoplasm; Enzyme Inhibitors; Immunoprecipitation; Isoenzymes; Molecular Sequence Data; Sequence Alignment; Toxoplasma

2005
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
    Chemical biology & drug design, 2006, Volume: 67, Issue:1

    Topics: Adenine; Adenosine Triphosphate; Bone and Bones; Carbon; Catalytic Domain; Cyclin-Dependent Kinase 2; Drug Design; Enzyme Inhibitors; Humans; Ligands; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Molecular; Neoplasms; Nitrogen; Organophosphonates; Protein Conformation; Purines; Pyrimidines; src-Family Kinases; Structure-Activity Relationship; Substrate Specificity

2006
Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2.
    Journal of the American Society of Nephrology : JASN, 2006, Volume: 17, Issue:9

    Topics: Adenine; Animals; Apoptosis; Cells, Cultured; Cisplatin; Creatinine; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Kidney Tubules, Proximal; Mice; Up-Regulation

2006
Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations.
    British journal of pharmacology, 2010, Volume: 160, Issue:4

    Topics: Absorption; Adenine; Antineoplastic Agents; Cell Line; Drug Screening Assays, Antitumor; Female; Fluorescent Dyes; Folic Acid Antagonists; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Laser Scanning Cytometry; Methotrexate; Microscopy, Fluorescence, Multiphoton; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyridones; Pyrimidines; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase

2010
Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.
    Cell cycle (Georgetown, Tex.), 2012, Oct-15, Volume: 11, Issue:20

    Topics: Adenine; Animals; Antineoplastic Agents; Biological Availability; Cell Cycle; Cerebellar Neoplasms; Chromatography, Liquid; Cyclin-Dependent Kinases; Dansyl Compounds; Humans; Magnetic Resonance Imaging; Medulloblastoma; Mice; Protein Kinase Inhibitors; Tandem Mass Spectrometry

2012
Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites.
    Malaria journal, 2015, Apr-08, Volume: 14

    Topics: Adenine; Cyclin-Dependent Kinases; Erythrocytes; Humans; Plasmodium falciparum; Proteome; Proteomics; Protozoan Proteins

2015
Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells.
    Molecular biology reports, 2018, Volume: 45, Issue:5

    Topics: Adenine; Autophagy; Cell Proliferation; Cell Survival; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Protein Kinase Inhibitors; Purines; Reactive Oxygen Species; Roscovitine; Time Factors; Unfolded Protein Response; Uterine Cervical Neoplasms

2018