adenine has been researched along with purvalanol b in 16 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (12.50) | 18.2507 |
2000's | 10 (62.50) | 29.6817 |
2010's | 4 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Barnes, G; Espinoza, FH; Gray, NS; Kim, SH; Kwon, S; LeClerc, S; Lockhart, DJ; Meijer, L; Morgan, DO; Norman, TC; Schultz, PG; Thunnissen, AM; Wodicka, L | 1 |
Chang, YT; Gray, NS; Kwon, S; Leost, M; Meijer, L; Norman, TC; Rosania, GR; Sarohia, R; Schultz, PG; Sutherlin, DP | 1 |
Doerig, C; Gray, N; Harmse, L; Havlik, I; Leclerc, S; Meijer, L; Schultz, P; van Zyl, R | 1 |
Adachi, S; Han, Z; Obaya, AJ; Ramos-Desimone, N; Sedivy, JM; Wyche, JH | 1 |
Bouget, FY; Brownlee, C; Corellou, F; Kloareg, B | 1 |
Bantly, A; Gray, NS; Knockaert, M; Malim, MH; Meijer, L; Schaffer, PA; Schang, LM; Shaheen, F | 1 |
Gray, N; Knockaert, M; Lenormand, P; Meijer, L; Pouysségur, J; Schultz, P | 1 |
Baumann, S; Becker, F; Bockovich, N; Come, J; Costa-Roldán, N; Dedier, S; Degenhart, C; Dill, S; Hanke, U; Hediger, M; Huber, A; Kaufmann, C; Kinsman, D; Kley, N; Kluge, AF; Meier-Ewert, S; Murthi, K; Smith, C; Wallner, W | 1 |
Donald, RG; Liberator, PA; Meijer, L; Zhong, T | 1 |
Adams, S; Andrade, L; Bohacek, R; Dalgarno, D; Grossman, T; Jin, L; Keats, J; Keenan, T; MacNeil, I; Metcalf, C; Narula, S; Ram, M; Sawyer, T; Schelling, P; Shakespeare, W; Stehle, T; Sundaramoorthi, R; van Schravendijk, MR; Wang, Y; Weigele, M | 1 |
Aleem, E; Kaldis, P; Megyesi, J; Nowak, G; Price, PM; Safirstein, RL; Yu, F | 1 |
Sera, T | 1 |
Becker, F; Brock, R; Chung, YD; Glauner, H; Hannus, S; Hansen, K; Ruttekolk, IR; Steemers, B | 1 |
Albanese, C; Das, S; Fricke, ST; Karam, S; Lee, YC; Lisanti, MP; Moasser, B; Ozcan, A; Petricoin, E; Pishvaian, M; Ringer, L; Rodriguez, OC; Rood, B; Salinas, P; Schlegel, R; Sirajuddin, P; Sivakumar, A; Üren, A; Wang, SS; Wang, Y; Yenugonda, V | 1 |
Broccardo, C; Bullard, KM; Keenan, SM | 1 |
Arisan, ED; Coker-Gurkan, A; Obakan-Yerlikaya, P; Ozfiliz-Kilbas, P; Palavan-Unsal, N; Sarikaya, B; Temizci, B | 1 |
1 review(s) available for adenine and purvalanol b
Article | Year |
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[Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors].
Topics: Adenine; Cell Division; Cyclin-Dependent Kinases; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Genomics; Humans; Kinetin; Ligands; Microarray Analysis; Small Molecule Libraries; Tumor Cells, Cultured | 2007 |
15 other study(ies) available for adenine and purvalanol b
Article | Year |
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Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.
Topics: Adenine; Binding Sites; CDC2-CDC28 Kinases; CDC28 Protein Kinase, S cerevisiae; Cell Division; Crystallography, X-Ray; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Flavonoids; Gene Expression Regulation, Fungal; Genes, Fungal; Humans; Hydrogen Bonding; Oligonucleotide Probes; Phosphates; Piperidines; Protein Serine-Threonine Kinases; Purines; RNA, Messenger; Saccharomyces cerevisiae; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors.
Topics: Adenine; Binding Sites; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cyclin A; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Humans; Ligands; Models, Molecular; Protein Conformation; Purines; Structure-Activity Relationship; Tumor Cells, Cultured | 1999 |
Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.
Topics: Adenine; Animals; Antimalarials; Cell Cycle; Dose-Response Relationship, Drug; Isopentenyladenosine; Kinetin; Parasitic Sensitivity Tests; Phosphotransferases; Plasmodium falciparum; Purines; Roscovitine; Structure-Activity Relationship | 2001 |
c-Myc is necessary for DNA damage-induced apoptosis in the G(2) phase of the cell cycle.
Topics: Adenine; Animals; Apoptosis; CDC2-CDC28 Kinases; Cell Line; Cisplatin; Cross-Linking Reagents; Cyclin A; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Etoposide; Flow Cytometry; G1 Phase; G2 Phase; Immunoblotting; Kinetics; Mutagenesis, Site-Directed; Nucleic Acid Synthesis Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-myc; Rats; Recombination, Genetic; Time Factors; Transgenes | 2001 |
Cell cycle-dependent control of polarised development by a cyclin-dependent kinase-like protein in the Fucus zygote.
Topics: Adenine; Algal Proteins; Aphidicolin; Cell Cycle; Cell Polarity; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Kinetin; Microinjections; Phaeophyceae; Purines; Zygote | 2001 |
Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins.
Topics: Adenine; Animals; Antiviral Agents; Cell Cycle; Cell Line; Chlorocebus aethiops; Cyclin-Dependent Kinases; Drug Resistance, Viral; Enzyme Inhibitors; HIV-1; Humans; Purines; Roscovitine; Simplexvirus; Vero Cells; Viral Proteins; Virus Replication | 2002 |
p42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol.
Topics: Adenine; Animals; Blotting, Western; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Cricetinae; Cyclin-Dependent Kinases; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molecular Structure; Nucleolin; Phosphoproteins; Phosphorylation; RNA-Binding Proteins; Transfection | 2002 |
A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors.
Topics: Adenine; Animals; Binding Sites; CDC2 Protein Kinase; Cyclin-Dependent Kinases; Enzyme Inhibitors; Ligands; Protein Array Analysis; Proteome; Saccharomyces; Two-Hybrid System Techniques | 2004 |
Characterization of two T. gondii CK1 isoforms.
Topics: Adenine; Amino Acid Sequence; Animals; Antiprotozoal Agents; Blotting, Western; Casein Kinase I; Casein Kinase Ialpha; Cell Membrane; Cloning, Molecular; Cytoplasm; Enzyme Inhibitors; Immunoprecipitation; Isoenzymes; Molecular Sequence Data; Sequence Alignment; Toxoplasma | 2005 |
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Topics: Adenine; Adenosine Triphosphate; Bone and Bones; Carbon; Catalytic Domain; Cyclin-Dependent Kinase 2; Drug Design; Enzyme Inhibitors; Humans; Ligands; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Molecular; Neoplasms; Nitrogen; Organophosphonates; Protein Conformation; Purines; Pyrimidines; src-Family Kinases; Structure-Activity Relationship; Substrate Specificity | 2006 |
Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2.
Topics: Adenine; Animals; Apoptosis; Cells, Cultured; Cisplatin; Creatinine; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Kidney Tubules, Proximal; Mice; Up-Regulation | 2006 |
Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations.
Topics: Absorption; Adenine; Antineoplastic Agents; Cell Line; Drug Screening Assays, Antitumor; Female; Fluorescent Dyes; Folic Acid Antagonists; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Laser Scanning Cytometry; Methotrexate; Microscopy, Fluorescence, Multiphoton; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyridones; Pyrimidines; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase | 2010 |
Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI.
Topics: Adenine; Animals; Antineoplastic Agents; Biological Availability; Cell Cycle; Cerebellar Neoplasms; Chromatography, Liquid; Cyclin-Dependent Kinases; Dansyl Compounds; Humans; Magnetic Resonance Imaging; Medulloblastoma; Mice; Protein Kinase Inhibitors; Tandem Mass Spectrometry | 2012 |
Effects of cyclin-dependent kinase inhibitor Purvalanol B application on protein expression and developmental progression in intra-erythrocytic Plasmodium falciparum parasites.
Topics: Adenine; Cyclin-Dependent Kinases; Erythrocytes; Humans; Plasmodium falciparum; Proteome; Proteomics; Protozoan Proteins | 2015 |
Cyclin-dependent kinase inhibitors, roscovitine and purvalanol, induce apoptosis and autophagy related to unfolded protein response in HeLa cervical cancer cells.
Topics: Adenine; Autophagy; Cell Proliferation; Cell Survival; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Protein Kinase Inhibitors; Purines; Reactive Oxygen Species; Roscovitine; Time Factors; Unfolded Protein Response; Uterine Cervical Neoplasms | 2018 |