adenine and probenecid

adenine has been researched along with probenecid in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's2 (13.33)18.2507
2000's7 (46.67)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Spector, R1
Cramer, H; Lindl, T1
Dorrestein, GM; Franssen, FF; Hermsen, RC; Nieuwenhuijs, H; Overdulve, JP; Smeijsters, LJ1
Cundy, KC1
Cihlar, T; Ho, ES; Lin, DC; Mendel, DB1
Miller, DS1
Aymard, G; Deray, G; Isnard Bagnis, C; Jaudon, MC; Lechat, P; Servais, A; Urien, S; Zahr, N2
Ida, H; Inui, K; Katsura, T; Tsuji, Y; Uwai, Y1
E, L; Liu, H; Wang, D; Wu, X; Yu, L1
Benhamou, Y; Izzedine, H; Peytavin, G; Schneider, L; Thibault, V; Valantin, MA1
Fujita, T; Horita, S; Ikeda, Y; Kondo, T; Kumagai, Y; Kusuhara, H; Maeda, K; Nakayama, H; Sugiyama, Y; Tanabe, K; Tian, Y1

Reviews

1 review(s) available for adenine and probenecid

ArticleYear
Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir.
    Clinical pharmacokinetics, 1999, Volume: 36, Issue:2

    Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Drug Interactions; Humans; Infusions, Intravenous; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Insufficiency

1999

Trials

1 trial(s) available for adenine and probenecid

ArticleYear
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Aug-01, Volume: 59

    Topics: Adenine; Adult; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; p-Aminohippuric Acid; Penicillin G; Probenecid; Young Adult

2014

Other Studies

13 other study(ies) available for adenine and probenecid

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Hypoxanthine transport through the blood-brain barrier.
    Neurochemical research, 1987, Volume: 12, Issue:9

    Topics: Adenine; Animals; Blood-Brain Barrier; Hypoxanthine; Hypoxanthines; Inosine; Leucine; Probenecid; Rats; Rats, Inbred Strains; Theophylline; Thiamine; Uracil

1987
Formation, accumulation and release of adenosine 3',5'-monophosphate induced by histamine in the superior cervical ganglion of the rat in vitro.
    Biochimica et biophysica acta, 1974, Mar-20, Volume: 343, Issue:1

    Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Carbon Radioisotopes; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cyclic AMP; Diphenhydramine; Dose-Response Relationship, Drug; Epinephrine; Ganglia, Spinal; Histamine; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase; Male; Phosphoric Diester Hydrolases; Practolol; Probenecid; Rats; Time Factors; Tritium

1974
Antimalarial and toxic effects of the acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine in Plasmodium berghei-infected mice.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:7

    Topics: Adenine; Animals; Antimalarials; Delayed-Action Preparations; Malaria; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Plasmodium berghei; Probenecid

1996
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.
    Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:3

    Topics: Adenine; Alanine; Animals; Anion Transport Proteins; Antiviral Agents; Biological Transport; Carrier Proteins; CHO Cells; Cidofovir; Cricetinae; Cytosine; Humans; Kidney; Organophosphate Poisoning; Organophosphonates; Organophosphorus Compounds; Probenecid

2000
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Kidney Tubules, Proximal; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Agents; Xenobiotics

2001
Tubular transporters and clearance of adefovir.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Adenine; Animals; ATP-Binding Cassette Transporters; Biological Transport; Chromatography, High Pressure Liquid; Coproporphyrins; Immunosuppressive Agents; Kidney Tubules; Male; Metabolic Clearance Rate; Models, Biological; Mutation; Organic Anion Transport Protein 1; Organophosphonates; Probenecid; Rats; Rats, Wistar; Time Factors; Uricosuric Agents

2006
[Tubular transporters OAT1 and MRP2 and clearance of adefovir].
    Nephrologie & therapeutique, 2005, Volume: 1, Issue:5

    Topics: Adenine; Animals; Antiviral Agents; Kidney; Male; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Probenecid; Rats; Rats, Wistar; Uricosuric Agents

2005
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).
    Pharmaceutical research, 2007, Volume: 24, Issue:4

    Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Humans; Kidney; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Probenecid; Tenofovir; Transfection

2007
Uptake of metronidazole by human gingival fibroblasts.
    Journal of periodontology, 2009, Volume: 80, Issue:6

    Topics: Adenine; Adjuvants, Pharmaceutic; Adolescent; Anti-Infective Agents; Cation Transport Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Diffusion; Extracellular Fluid; Fibroblasts; Gingiva; Humans; Hydrogen-Ion Concentration; Intracellular Fluid; Male; Membrane Transport Modulators; Metronidazole; Microbial Sensitivity Tests; Probenecid; Temperature; Time Factors

2009
Tenofovir/probenecid combination in HIV/HBV-coinfected patients: how to escape Fanconi syndrome recurrence?
    AIDS (London, England), 2010, Apr-24, Volume: 24, Issue:7

    Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Probenecid; Secondary Prevention; Tenofovir

2010