Compounds > adenine

adenine and methyl 4-(adenin-9-yl)-2-hydroxybutanoate

adenine has been researched along with methyl 4-(adenin-9-yl)-2-hydroxybutanoate in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (36.36)29.6817
2010's6 (54.55)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Fu, YF; He, PL; Lawson, BR; Li, C; Li, XY; Ni, J; Tang, W; Wang, JX; Yang, Y; Yang, YF; Zhao, Y; Zhou, R; Zhu, YN; Zuo, JP1
Fu, YF; Lawson, BR; Nan, FJ; Ni, J; Re, YD; Shi, LP; Tang, W; Wan, J; Yang, YF; Yuan, C; Zhong, XG; Zhu, YN; Zuo, JP1
Ahamed, J; Baccala, R; Chen, X; Lawson, BR; Manenkova, Y; Theofilopoulos, AN; Yuan, C; Zou, JP1
Ding, Y; Gu, M; Lu, W; Luo, W; Nan, FJ; Tang, J; Tang, W; Zhang, YM; Zuo, JP1
Bowers, BE; Campbell, EL; Colgan, SP; Collins, CB; Glover, LE; Keely, S; Kominsky, DJ; MacManus, CF; Scully, M1
Berger, M; Hoebe, K; Kono, DH; Lawson, BR; Manenkova, Y; Tardif, V; Theofilopoulos, AN; Yuan, C; Zuo, JP1
Bai, BX; He, PL; He, SJ; Lin, ZM; Tang, W; Wu, YW; Yang, XQ; Zhu, FH; Zuo, JP1
He, SJ; Li, H; Lin, ZM; Liu, YT; Ma, M; Qi, Q; Shen, YF; Tang, W; Yan, YX; Yang, XQ; Zhu, FH; Zuo, JP1
Gu, L; He, S; Lin, Z; Liu, X; Liu, Y; Tang, W; Zhou, H; Zuo, J1
Fan, C; Feng, C; Li, H; Lu, H; Niu, L; Qi, Q; Tang, W; Wu, B; Wu, Y; Zhang, Z; Zuo, J1
Cao, S; Chen, L; He, S; Huang, Y; Lin, Z; Liu, Y; Tang, W; Yang, X; Zhu, F; Zuo, J1

Other Studies

11 other study(ies) available for adenine and methyl 4-(adenin-9-yl)-2-hydroxybutanoate

ArticleYear
S-adenosyl-L-homocysteine hydrolase inactivation curtails ovalbumin-induced immune responses.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:3

    Topics: Adenine; Adenosylhomocysteinase; Animals; Antibody Formation; Butyrates; Cytokines; Enzyme Inhibitors; Immunoglobulin G; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Ovalbumin; S-Adenosylhomocysteine

2006
A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:2

    Topics: Adenine; Adenosylhomocysteinase; Amino Acid Sequence; Animals; Antigen Presentation; Butyrates; CD3 Complex; Cell Cycle; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Glycoproteins; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; T-Lymphocytes

2006
Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.
    Journal of immunology (Baltimore, Md. : 1950), 2007, Apr-15, Volume: 178, Issue:8

    Topics: Adenine; Adenosylhomocysteinase; Animals; Autoimmune Diseases; Butyrates; Calcium; CD4-Positive T-Lymphocytes; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Jurkat Cells; Lymphocyte Activation; Methylation; Mice; Proto-Oncogene Proteins c-vav; Receptors, Antigen, T-Cell; Signal Transduction

2007
Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers.
    Bioorganic & medicinal chemistry, 2008, Oct-15, Volume: 16, Issue:20

    Topics: Adenine; Adenosylhomocysteinase; Animals; Butyrates; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Immunosuppressive Agents; Mice; Models, Molecular; Molecular Structure; Rabbits; Stereoisomerism

2008
An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Jun-01, Volume: 186, Issue:11

    Topics: Adenine; Adenosylhomocysteinase; Animals; Blotting, Western; Butyrates; Cell Line, Tumor; Colitis; Colon; Dextran Sulfate; DNA Methylation; Epithelial Cells; Gene Expression Profiling; HeLa Cells; Humans; Inflammation; Interferon-gamma; Intestinal Mucosa; Magnetic Resonance Spectroscopy; Metabolomics; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred C57BL; Mucositis; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction

2011
Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.
    Clinical immunology (Orlando, Fla.), 2013, Volume: 147, Issue:2

    Topics: Adenine; Animals; Antigen-Presenting Cells; Autoantibodies; B-Lymphocytes; Butyrates; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Female; Immunoglobulin G; Immunosuppressive Agents; Kidney; Lupus Erythematosus, Systemic; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Protein Processing, Post-Translational; Signal Transduction; Toll-Like Receptors

2013
Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response.
    Acta pharmacologica Sinica, 2014, Volume: 35, Issue:2

    Topics: Adenine; Animals; Antigen-Presenting Cells; Butyrates; Dendritic Cells; Female; Glomerulonephritis; Humans; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NZB; Toll-Like Receptors

2014
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17.
    Pharmacological research, 2018, Volume: 129

    Topics: Adenine; Adenosylhomocysteinase; Administration, Topical; Animals; Anti-Inflammatory Agents; Butyrates; Cells, Cultured; Cytokines; Female; Humans; Imiquimod; Keratinocytes; Mice, Inbred BALB C; Psoriasis; T-Lymphocytes

2018
Reversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage.
    Arthritis research & therapy, 2019, 01-29, Volume: 21, Issue:1

    Topics: Actinin; Adenine; Adenosylhomocysteinase; Animals; Butyrates; Cytoskeleton; Down-Regulation; Humans; Integrins; Kidney; Lupus Nephritis; Mice, Inbred C57BL; Mice, Inbred NZB; Protective Agents; Protein Binding; Protein Interaction Maps; Proteomics

2019
DZ2002 ameliorates fibrosis, inflammation, and vasculopathy in experimental systemic sclerosis models.
    Arthritis research & therapy, 2019, 12-16, Volume: 21, Issue:1

    Topics: Adenine; Animals; Bleomycin; Butyrates; Cell Line; Cells, Cultured; Dermis; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Gene Expression; Humans; Inflammation; Macrophages; Mice, Inbred C57BL; Scleroderma, Systemic; THP-1 Cells; Transforming Growth Factor beta; Vascular Diseases; Vascular Endothelial Growth Factor A

2019
DZ2002 alleviates psoriasis-like skin lesions via differentially regulating methylation of GATA3 and LCN2 promoters.
    International immunopharmacology, 2021, Volume: 91

    Topics: Adenine; Animals; Anti-Inflammatory Agents; Butyrates; Cell Differentiation; Cell Proliferation; Chemokines; Disease Models, Animal; DNA Methylation; Female; GATA3 Transcription Factor; HaCaT Cells; HL-60 Cells; Humans; Keratinocytes; Lipocalin-2; Mice, Inbred BALB C; Neutrophil Infiltration; Promoter Regions, Genetic; Psoriasis; Skin

2021