adenine and methotrexate

adenine has been researched along with methotrexate in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	25 (53.19)	18.7374
1990's	4 (8.51)	18.2507
2000's	7 (14.89)	29.6817
2010's	9 (19.15)	24.3611
2020's	2 (4.26)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Henderson, GB; Huennekens, FM; Suresh, MR	1
Irvin, AD; Stagg, DA	1
Wyss, C	1
Brox, LW; Henderson, JF; Hryniuk, WM; Tamaoki, T	1
Cronstein, BN; Eberle, MA; Gruber, HE; Levin, RI	1
Plagemann, PG; Wohlhueter, RM	1
Kummer, D	1
Grindey, GB; Moran, RG; Nichol, CA; Werkheiser, WC	1
Sprecher-Goldberger, S	2
Kadyrov, CS; Lloyd, RF; Shive, W; Skinner, CS	1
de Waard, H	1
Lipkin, M; Troncale, FJ	1
Doctor, VM	1
Sims, L	1
Oriuchi, T	1
Brockman, RW; Dixon, GJ; Dulmadge, EA; Shaddix, SC	1
Burchenal, JH; Butterbaugh, J; Dollinger, M; Giner-Sorolla, A; Stoll, D	1
Goren, HJ; Hollenberg, MD; Lederis, K; Okabe, T	1
Leyva, A; Pinedo, HM; Schornagel, JH; Uitendaal, MP	1
Henderson, GB; Huennekens, FM; Suresh, MR; Vitols, KS	1
Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Vandeputte, M; Waer, M	1
Chow, M; Koo, J; Ng, P; Rubin, H	1
Balzarini, J; De Clercq, E; Hatse, S; Naesens, L	1
Barnes, MJ; Newell, DR; Taylor, GA	1
Grosse-Wilde, H; Jacob, JR; Kreuzfelder, E; Maschke, J; Menne, S; Roggendorf, M; Tennant, BC	1
HUTCHISON, DJ; JOHNSON, AH	1
ALBRECHT, AM; HUTCHISON, DJ	1
BRINDLE, SD; HIRSCHBERG, E; SEMENTE, G	1
GREENBERG, NH; MEAD, JA; SCHRECKER, AW; SEEGER, DR; TOMCUFCIK, AS	1
LOEBECK, ME	1
Ambudkar, SV; Nandigama, K; Sauna, ZE	1
Brett, CM; Brown, C; Burchard, EG; Carlson, EJ; Castro, R; Chen, CW; de la Cruz, M; Ferrin, TE; Fujita, K; Fujita, T; Giacomini, KM; Huang, CC; Johns, SJ; Kawamoto, M; Leabman, MK; Lin, ET; Stryke, D; Taylor, T	1
Bian, JS; Boelsterli, UA; Chan, E; Chan, SY; Duan, W; Ho, PC; Huang, M; Li, X; Tan, TM; Tian, Q; Xiong, W; Yang, H; Zhang, J; Zhou, S; Zhu, YZ	1
Baggott, JE; Morgan, SL	1
Di Martino, V; Herbein, G; Prati, C; Toussirot, E; Wendling, D	1
Becker, F; Brock, R; Chung, YD; Glauner, H; Hannus, S; Hansen, K; Ruttekolk, IR; Steemers, B	1
Chen, HM; Chin, LT; Chiu, CD; Chu, CH; Hour, AL; Hu, KY; Huang, NK; Huang, PR; Shui, HA	1
Ambudkar, SV; Cheepala, SB; Ekins, S; Fukuda, Y; Schuetz, JD; Sparreboom, A; Takenaka, K; Wu, CP	1
Batey, RT; Trausch, JJ	1
Chen, K; Duan, WM; Gong, FR; Gui, Q; Li, DM; Li, W; Lian, L; Liu, L; Shen, M; Tao, M; Wang, WJ; Wu, MY; Xu, MD; Zhu, J	1
Almarzouqi, SJ; Chevez-Barrios, P; Khan, K; Lee, AG; Malik, AI; Morgan, ML; Yalamanchili, S	1
Berger, MF; Campos, C; Codega, P; Daras, M; DeAngelis, LM; Grommes, C; Hatzoglou, V; Kaley, TJ; Lin, A; Manne, M; Mellinghoff, IK; Nolan, CP; Panageas, KS; Pentsova, EI; Piotrowski, AF; Reiner, AS; Stone, J; Tang, SS; Thomas, AA; Viale, A; Wolfe, J	1
Chen, F; Guo, H; Huang, L; Jiang, X; Li, W; Liang, Z; Liu, S; Ou, Q; Pang, D; Wei, X; Wu, X; Zhou, D	1
Badillo, M; Fayad, L; Feng, L; Flowers, CR; Fowler, N; Hagemeister, FB; Hill, HA; Iyer, SP; Jain, P; Jorgensen, J; Kanagal-Shamanna, R; Lee, HJ; Li, S; Lin, P; Medeiros, LJ; Nair, R; Nastoupil, L; Navsaria, L; Nogueras Gonzalez, GM; Ok, CY; Patel, KP; Samaniego, F; Santos, D; Steiner, R; Tang, G; Thirumurthi, S; Vega, F; Wagner-Bartak, N; Wang, L; Wang, ML; Wang, SA; Westin, JR; Xu, G; Xuelin, H; Yao, Y; Yin, CC; Zhao, S	1

Reviews

1 review(s) available for adenine and methotrexate

Article	Year
The cell cycle and the development of pathology in the gastrointestinal tract. Pathobiology annual, 1972, Volume: 2 Topics: Adenine; Animals; Autoradiography; Cell Count; Cell Division; Colon; Digestive System; DNA; Flucytosine; Fluorouracil; Humans; Intestine, Small; Methotrexate; Pentosyltransferases; RNA; Stomach; Thymidine; Thymidine Kinase; Tritium	1972

Trials

2 trial(s) available for adenine and methotrexate

Article	Year
Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma. Blood, 2019, 01-31, Volume: 133, Issue:5 Topics: Adenine; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Circulating Tumor DNA; Female; Humans; Lymphoma; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rituximab; Treatment Outcome; Young Adult	2019
Ibrutinib-rituximab followed by R-HCVAD as frontline treatment for young patients (≤65 years) with mantle cell lymphoma (WINDOW-1): a single-arm, phase 2 trial. The Lancet. Oncology, 2022, Volume: 23, Issue:3 Topics: Adenine; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Humans; Lymphoma, Mantle-Cell; Lymphopenia; Methotrexate; Middle Aged; Piperidines; Rituximab; Thrombocytopenia; Treatment Outcome; Vincristine	2022

Article

Year

Phase 1b trial of an ibrutinib-based combination therapy in recurrent/refractory CNS lymphoma.

Blood, 2019, 01-31, Volume: 133, Issue:5

Topics: Adenine; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Circulating Tumor DNA; Female; Humans; Lymphoma; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Rituximab; Treatment Outcome; Young Adult

2019

Ibrutinib-rituximab followed by R-HCVAD as frontline treatment for young patients (≤65 years) with mantle cell lymphoma (WINDOW-1): a single-arm, phase 2 trial.

The Lancet. Oncology, 2022, Volume: 23, Issue:3

Topics: Adenine; Adult; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Cytarabine; Doxorubicin; Humans; Lymphoma, Mantle-Cell; Lymphopenia; Methotrexate; Middle Aged; Piperidines; Rituximab; Thrombocytopenia; Treatment Outcome; Vincristine

2022

Other Studies

44 other study(ies) available for adenine and methotrexate

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Folate uptake in L1210 cells: mediation by an adenine transport system. Biochemical and biophysical research communications, 1979, Mar-15, Volume: 87, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Biological Transport, Active; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice	1979
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells. Experimental parasitology, 1977, Volume: 41, Issue:1 Topics: Adenine; Aminopterin; Animals; Azaguanine; Cattle; Cells, Cultured; Culture Media; Eukaryota; Floxuridine; Folic Acid Antagonists; Guanine; Hypoxanthines; Lymphocytes; Methotrexate; Purines; Pyrimidine Nucleosides; Theileriasis; Thymidine; Uridine	1977
TAM selection of Drosophila somatic cell hybrids. Somatic cell genetics, 1979, Volume: 5, Issue:1 Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Cell Line; Drosophila; Drug Resistance; Hybrid Cells; Isocitrate Dehydrogenase; Methotrexate; Mutation; Pentosyltransferases; Phenotype; Thymidine	1979
Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells. Cancer research, 1975, Volume: 35, Issue:6 Topics: Adenine; Adenosine Triphosphate; Animals; Cell Line; Cytosine Nucleotides; Depression, Chemical; DNA; Guanine; Guanosine Triphosphate; Hypoxanthines; Leucine; Leukemia, Lymphoid; Methotrexate; Mice; Purines; RNA; Thymidine; Time Factors; Uracil Nucleotides; Uridine	1975
Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proceedings of the National Academy of Sciences of the United States of America, 1991, Mar-15, Volume: 88, Issue:6 Topics: Adenine; Adenosine; Analysis of Variance; Cell Line; Cells, Cultured; Connective Tissue; Endothelium, Vascular; Fibroblasts; Humans; In Vitro Techniques; Kinetics; Methotrexate; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Umbilical Veins	1991
S49 mouse lymphoma cells are deficient in hypoxanthine transport. Biochimica et biophysica acta, 1986, Feb-13, Volume: 855, Issue:1 Topics: Adenine; Animals; Biological Transport; Cell Line; Cricetinae; Cricetulus; Dipyridamole; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Lymphoma; Methotrexate; Mice; Permeability; Thymidine; Uridine; Uridine Kinase	1986
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro]. Zeitschrift fur Krebsforschung, 1970, Volume: 74, Issue:1 Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine	1970
Combinations of drugs which interact as inhibitors of DNA biosynthesis. Advances in enzyme regulation, 1972, Volume: 10 Topics: Adenine; Animals; Antineoplastic Agents; Arabinose; Cytosine; DNA, Neoplasm; Drug Interactions; Floxuridine; Methotrexate; Mice	1972
The existence of two different metabolic patterns for the synthesis of RNA viruses. Archiv fur die gesamte Virusforschung, 1966, Volume: 18, Issue:2 Topics: Adenine; Animals; Antimetabolites; Chick Embryo; Culture Media; Dactinomycin; Enterovirus; Fibroblasts; Formates; Histones; Influenza A virus; Methotrexate; Nucleosides; Orotic Acid; Phenylalanine; Puromycin; Radiation Effects; RNA Viruses; RNA, Viral; Thymidine; Ultraviolet Rays; Uridine	1966
Isosteric relationship of biologically active N 6 -( -phenylalkyl) adenines and N 6 -( -1',4'-xyxlohwzadien-1'-y-alkyl)adenines. Archives of biochemistry and biophysics, 1971, Volume: 143, Issue:1 Topics: Adenine; Amines; Aminopterin; Ammonia; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Cyclohexanes; Electron Spin Resonance Spectroscopy; Gibberellins; Lactobacillus; Lithium; Methotrexate; Oxidation-Reduction; Plant Growth Regulators; Purines; Seeds	1971
[Effect of thymine and adenine in nutrition on folic-acid deficient rats]. Zeitschrift fur Ernahrungswissenschaft, 1974, Volume: 13, Issue:3 Topics: Adenine; Animals; Female; Folic Acid Deficiency; Male; Methotrexate; Rats; Thymine	1974
Inhibition of methotrexate resistant mutant of Streptococcus faecalis by analogs of purine and pyrimidine. Chemotherapy, 1970, Volume: 15, Issue:1 Topics: Adenine; Adenine Nucleotides; Azaguanine; Drug Resistance, Microbial; Enterococcus faecalis; Guanine; Kinetics; Mercaptopurine; Methotrexate; Mutation; Nucleosides; Purines; Pyrimidines; Thioguanine; Thymine	1970
Drugs used in radiotherapy. Radiography, 1972, Volume: 38, Issue:448 Topics: Adenine; Alkylating Agents; Analgesics; Anemia; Anti-Bacterial Agents; Antiemetics; Antimetabolites; Antineoplastic Agents; Drug Therapy; Expectorants; Folic Acid; Humans; Mercaptopurine; Methotrexate; Neoplasms; Pharmaceutical Preparations; Radiotherapy; Steroids; Tranquilizing Agents; Vitamins	1972
[On uptake of 5-FU, 6-MP and methotrexate by ehrlich ascites tumor cells in vitro]. Sapporo igaku zasshi. The Sapporo medical journal, 1970, Volume: 37, Issue:6 Topics: Adenine; Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Fluorouracil; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Mice; Sulfur Isotopes; Time Factors; Tritium; Uracil	1970
Feedback inhibition of purine biosynthesis in adenocarcinoma 755 and sarcoma 180 cells in culture. Journal of the National Cancer Institute, 1970, Volume: 45, Issue:4 Topics: Adenine; Adenocarcinoma; Animals; Azaserine; Carbon Isotopes; Cell Line; Feedback; Hypoxanthines; Mercaptopurine; Methotrexate; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Purines; Sarcoma 180; Thioguanine	1970
Studies of 6-N-hydroxylamino-9-beta-D-ribofuranosylpurine in mouse leukemia. Biochemical pharmacology, 1967, Volume: 16, Issue:3 Topics: Adenine; Animals; Body Weight; Cytarabine; Drug Antagonism; Drug Synergism; Fluorouracil; Guanine; Leukemia; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Nucleosides; Phosphotransferases; Purines; Vincristine	1967
Oxytocin stimulates glucose oxidation in rat thymocytes. Proceedings of the Western Pharmacology Society, 1984, Volume: 27 Topics: Adenine; Animals; Cycloheximide; Glucose; In Vitro Techniques; Inosine; Kinetics; Male; Methotrexate; Oxidation-Reduction; Oxytocin; Rats; Rats, Inbred Strains; Thymus Gland	1984
Synergism between purines and thymidine (TDR) in reversal of methotrexate (MTX) toxicity in mice using continuous infusions. Advances in experimental medicine and biology, 1984, Volume: 165 Pt B Topics: Adenine; Animals; Drug Synergism; Female; Infusions, Parenteral; Inosine; Kinetics; Methotrexate; Mice; Mice, Inbred DBA; Thymidine	1984
Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells. Advances in enzyme regulation, 1982, Volume: 20 Topics: Adenine; Animals; Biological Transport; Energy Metabolism; Folic Acid; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms; Pterins; Tetrahydrofolate Dehydrogenase	1982
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma. Advances in experimental medicine and biology, 1998, Volume: 431 Topics: Adenine; Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Choriocarcinoma; Methotrexate; Organophosphonates; Progesterone; Rats; Rats, Inbred Strains; Stereoisomerism	1998
Random population-wide genetic damage induced in replicating cells treated with methotrexate. Mutation research, 1998, Mar-30, Volume: 413, Issue:3 Topics: 3T3 Cells; Adenine; Animals; Antimetabolites, Antineoplastic; Cell Cycle; Culture Media; DNA Damage; Folic Acid Antagonists; Hypoxanthine; Methotrexate; Mice; Mutagenicity Tests; Thymidine	1998
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model. Biochemical pharmacology, 1998, Oct-01, Volume: 56, Issue:7 Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Neoplasm; Antigens, Surface; Antiviral Agents; Cell Differentiation; Cell Survival; Choriocarcinoma; Drug Therapy, Combination; Enzyme Induction; Growth Inhibitors; Kidney Neoplasms; Methotrexate; Organophosphonates; Organophosphorus Compounds; Progesterone; Rats; Rats, Inbred Strains; Rats, Wistar; Retroviridae; Tenofovir; Trophoblasts; Tumor Cells, Cultured	1998
Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells. Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4 Topics: Adenine; Antimetabolites, Antineoplastic; Child; Guanine; Humans; Inosine; Leukemia; Methotrexate; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured	2000
Thymidine utilization abnormality in proliferating lymphocytes and hepatocytes of the woodchuck. Veterinary immunology and immunopathology, 2001, Feb-10, Volume: 78, Issue:3-4 Topics: 3T3 Cells; Adenine; Animals; Blotting, Northern; Blotting, Southern; Cell Division; Humans; Liver; Lymphocytes; Marmota; Methotrexate; Mice; Models, Biological; Serine; Thymidine; Thymidine Kinase; Thymidine Monophosphate	2001
A DIFFERENTIAL EFFECT OF ETHIDIUM CHLORIDE ON THE GROWTH OF ARBO A VIRUSES AND THEIR SMALL PLAQUE MUTANTS. Acta virologica, 1964, Volume: 8 Topics: Adenine; Animals; Antineoplastic Agents; Encephalitis Viruses; Encephalomyelitis; Encephalomyelitis, Equine; Ethidium; Folic Acid Antagonists; Horses; Methotrexate; Newcastle disease virus; Pharmacology; Research; Virus Cultivation	1964
FOLIC ACID METABOLISM IN ANTIFOLIC-RESISTANT MUTANTS OF STREPTOCOCCUS FAECALIS. Journal of bacteriology, 1964, Volume: 87 Topics: Adenine; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Guanine; Metabolism; Methotrexate; Mutation; Purines; Research; Serine; Thymine; Xanthines	1964
REPRESSION BY ADENINE OF THE FORMYLTETRAHYDROFOLATE SYNTHETASE IN AN ANTIFOLIC-RESISTANT MUTANT OF STREPTOCOCCUS FAECALIS. Journal of bacteriology, 1964, Volume: 87 Topics: Adenine; Bacteriological Techniques; Drug Resistance, Microbial; Enterococcus faecalis; Folic Acid; Formate-Tetrahydrofolate Ligase; Guanine; Ligases; Methotrexate; Mutation; Purines; Research; Tetrahydrofolate Dehydrogenase; Thymine	1964
DEVELOPMENT AND PROPERTIES OF MOUSE LEUKEMIA L1210 RESISTANT TO MIRACIL D. Cancer research, 1964, Volume: 24 Topics: Adenine; Animals; Azaguanine; Cyclophosphamide; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Leucovorin; Leukemia L1210; Lucanthone; Mercaptopurine; Methotrexate; Mice; Pharmacology; Proadifen; Pyridoxine; Research; Thioguanine	1964
THE PHARMACOLOGICAL AND BIOCHEMICAL ACTIVITY OF 4-AMINO-4-DEOXY-10-METHYLPTEROYLASPARTIC ACID. Biochemical pharmacology, 1965, Volume: 14 Topics: Adenine; Amino Acids; Animals; Aspartic Acid; Enzyme Inhibitors; Folic Acid; Formates; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Research	1965
Prevention of amethopterin inhibition by 2-methyladenine. Journal of bacteriology, 1960, Volume: 79 Topics: Adenine; Folic Acid Antagonists; Methotrexate	1960
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state. The Journal of biological chemistry, 2004, Nov-19, Volume: 279, Issue:47 Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; Biological Transport; Catalysis; Cations; Cell Line; Cell Membrane; Chelating Agents; Cobalt; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Fluorides; Humans; Hydrolysis; Insecta; Kinetics; Magnesium; Manganese; Methotrexate; Models, Biological; Multidrug Resistance-Associated Proteins; Nucleotides; Organophosphonates; Protein Binding; Substrate Specificity; Vanadates; Zidovudine	2004
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1). Pharmacogenetics and genomics, 2005, Volume: 15, Issue:4 Topics: Adenine; Adult; Animals; Anions; Antineoplastic Agents; DNA, Complementary; Genetic Variation; Genotype; Haplotypes; Heterozygote; Humans; Kidney; Kinetics; Male; Methotrexate; Models, Chemical; Models, Genetic; Mycotoxins; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters; Organophosphonates; p-Aminohippuric Acid; Pedigree; Pharmacogenetics; Polymorphism, Genetic; Protein Structure, Secondary; RNA, Complementary; Xenobiotics; Xenopus laevis	2005
Human multidrug resistance associated protein 4 confers resistance to camptothecins. Pharmaceutical research, 2005, Volume: 22, Issue:11 Topics: Adenine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Drug Resistance, Neoplasm; Glutathione; Humans; Irinotecan; Methotrexate; Multidrug Resistance-Associated Proteins; Organophosphonates; Paclitaxel	2005
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 31, Issue:2 Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Rats; Ribonucleosides	2007
Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy. Joint bone spine, 2009, Volume: 76, Issue:3 Topics: Adenine; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Antiviral Agents; Drug Therapy, Combination; Etanercept; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Immunoglobulin G; Infliximab; Lamivudine; Male; Methotrexate; Organophosphonates; Receptors, Tumor Necrosis Factor; Spondylarthropathies; Treatment Outcome; Tumor Necrosis Factor-alpha; Viral Load; Virus Activation	2009
Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations. British journal of pharmacology, 2010, Volume: 160, Issue:4 Topics: Absorption; Adenine; Antineoplastic Agents; Cell Line; Drug Screening Assays, Antitumor; Female; Fluorescent Dyes; Folic Acid Antagonists; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Laser Scanning Cytometry; Methotrexate; Microscopy, Fluorescence, Multiphoton; Polyethylene Glycols; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyridones; Pyrimidines; Recombinant Fusion Proteins; Tetrahydrofolate Dehydrogenase	2010
A proteomics-based translational approach reveals an antifolate resistance inherent in human plasma derived from blood donation. Journal of proteome research, 2010, Jun-04, Volume: 9, Issue:6 Topics: Adenine; Aminopterin; Animals; Blood Preservation; Blood Proteins; Blood Transfusion; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Dose-Response Relationship, Drug; Drug Resistance; Drug Stability; Electrophoresis, Gel, Two-Dimensional; Folic Acid Antagonists; Humans; Kaplan-Meier Estimate; Methotrexate; Mice; Preservatives, Pharmaceutical; Proteomics; Retrospective Studies; Systems Biology; Up-Regulation	2010
Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity. Molecular pharmacology, 2013, Volume: 84, Issue:3 Topics: Adenine; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Hydrolysis; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Multidrug Resistance-Associated Proteins; Nelfinavir; Organophosphonates; Ritonavir	2013
A disconnect between high-affinity binding and efficient regulation by antifolates and purines in the tetrahydrofolate riboswitch. Chemistry & biology, 2014, Feb-20, Volume: 21, Issue:2 Topics: Adenine; Binding Sites; Folic Acid Antagonists; Leucovorin; Methotrexate; Molecular Docking Simulation; Nucleic Acid Conformation; Purines; Riboswitch; Tetrahydrofolates; Transcription Termination, Genetic	2014
Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin. Oncology reports, 2015, Volume: 34, Issue:1 Topics: Adenine; Antineoplastic Agents; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cisplatin; Cyclophosphamide; Docetaxel; Epirubicin; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Taxoids	2015
Optic Neuropathy Due to Chronic Lymphocytic Leukemia Proven With Optic Nerve Sheath Biopsy. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2016, Volume: 36, Issue:1 Topics: Adenine; Antimetabolites, Antineoplastic; Biopsy; Drug Therapy, Combination; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Magnetic Resonance Imaging; Male; Methotrexate; Middle Aged; Optic Nerve; Papilledema; Piperidines; Pyrazoles; Pyrimidines; Spinal Puncture	2016
Clinical outcomes of newly diagnosed primary CNS lymphoma treated with ibrutinib-based combination therapy: A real-world experience of off-label ibrutinib use. Cancer medicine, 2020, Volume: 9, Issue:22 Topics: Adenine; Adult; Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System Neoplasms; Disease Progression; Female; Humans; Lymphoma; Male; Methotrexate; Middle Aged; Off-Label Use; Piperidines; Progression-Free Survival; Protein Kinase Inhibitors; Retrospective Studies; Time Factors	2020