adenine and indomethacin

adenine has been researched along with indomethacin in 30 studies

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19908 (26.67)18.7374
1990's7 (23.33)18.2507
2000's9 (30.00)29.6817
2010's6 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duffy, EM; Jorgensen, WL1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Dozi-Vassiliades, J; Kokolis, N; Tsiamitas, C1
Davenport, K; Day, HJ; Mürer, EH; Rausch, MA1
Cornish, J; Gray, DH; Lowe, C; Reid, IR; Skinner, SJ1
Caswell, AM; Leong, WS; Russell, RG1
Authi, KS; Crawford, N; Evenden, BJ1
Lamprecht, SA; Lindner, HR; Tsafriri, A; Zor, U1
Cash, WD; Czernik, AJ; Fain, JN; Frost, S; Psychoyos, S1
Freis, ED; Limas, CJ; Ragan, D1
Bartlett, GR1
Macfarlane, DE1
Bowyer, DE; Davis, JB; McMurray, HF; Parrott, DP; Proudfoot, D1
Franková, D; Holý, A; Zídek, Z1
Annaert, P; Augustijns, P; De Clercq, E; Kinget, R; Naesens, L; Van den Mooter, G; Van Gelder, J1
Balzarini, J; De Clercq, E; Hatse, S1
Balcells, E; Ceballos, G; Rubio, R1
Burgaud, JL; Ea-Kim, L; Ghanam, K; Javellaud, J; Lavagna, C; Oudart, N1
Aragona, F; Malendowicz, LK; Nussdorfer, GG; Rebuffat, P; Tortorella, C1
Ardans, JA; Birkedal-Hansen, H; Caterina, N; Lai, WC; Mangan, PR; Netzel-Arnett, S; Shankavaram, UT; Stetler-Stevenson, WG; Wahl, LM1
Fahim, M; Mustafa, SJ1
Alfieri, A; Cicala, C; Mascolo, N; Morello, S; Vellecco, V1
Majewski, H; Zhao, J1
Hrabálek, A; Janůsová, B; Kovaríková, P; Novotný, J; Novotný, M; Vávrová, K1
De Koning, HP; Dogruel, M; Rodgers, J; Sanderson, L; Thomas, SA1
Borda, E; Busch, L; Miozza, V; S-Borda, L1
Arimizu, K; Chuang, VT; Hirata, S; Irie, T; Ishitsuka, Y; Kadowaki, D; Kitamura, K; Maruyama, T; Narita, Y; Otagiri, M; Sumikawa, S; Taguchi, K1
Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Suzawa, H1
Hahm, KB; Han, YM; Jeong, M; Kim, MY; Lee, HJ; Ock, CY; Park, JM1

Other Studies

30 other study(ies) available for adenine and indomethacin

ArticleYear
Prediction of drug solubility from Monte Carlo simulations.
    Bioorganic & medicinal chemistry letters, 2000, Jun-05, Volume: 10, Issue:11

    Topics: Monte Carlo Method; Pharmaceutical Preparations; Solubility

2000
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Studies in vitro on the effect of adenosine, adenine and NAD on guinea pig myometrium in the presence of exogenously applied PGE2.
    Archives internationales de physiologie et de biochimie, 1979, Volume: 87, Issue:1

    Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Female; Guinea Pigs; Indomethacin; Muscle Contraction; Myometrium; NAD; Prostaglandins E; Uterus

1979
Metabolic aspects of the secretion of stored compounds from blood platelets. V. Effect of ionophore A23187 on washed platelets.
    Biochimica et biophysica acta, 1976, Nov-18, Volume: 451, Issue:1

    Topics: Adenine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anti-Bacterial Agents; Blood Platelets; Calcimycin; Humans; Indomethacin; Inosine; Inosine Nucleotides; Kinetics; Serotonin

1976
Adenylate cyclase blockers dissociate PTH-stimulated bone resorption from cAMP production.
    The American journal of physiology, 1990, Volume: 258, Issue:4 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenylyl Cyclase Inhibitors; Animals; Bone and Bones; Bone Resorption; Calcium; Cyclic AMP; Dideoxyadenosine; DNA Replication; In Vitro Techniques; Indomethacin; Isomerism; Kinetics; Mice; Parathyroid Hormone; Phenylalanine; Protein Biosynthesis; Theophylline

1990
Evidence for the presence of P2-purinoceptors at the surface of human articular chondrocytes in monolayer culture.
    Biochimica et biophysica acta, 1991, May-24, Volume: 1074, Issue:1

    Topics: Adenine; Adenosine; Adenosine Triphosphate; Cartilage, Articular; Cells, Cultured; Humans; Indomethacin; Nucleotides; Pertussis Toxin; Prostaglandins E; Receptors, Purinergic; Theophylline; Virulence Factors, Bordetella

1991
Metabolic and functional consequences of introducing inositol 1,4,5-trisphosphate into saponin-permeabilized human platelets.
    The Biochemical journal, 1986, Feb-01, Volume: 233, Issue:3

    Topics: Adenine; Blood Platelets; Cell Membrane Permeability; Humans; Indomethacin; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Microscopy, Electron; Models, Biological; Platelet Aggregation; Receptors, Prostaglandin; Receptors, Thromboxane; Saponins; Serotonin; Sugar Phosphates

1986
Action of prostaglandin E 2 and of luteinizing hormone on ovarian adenylate cyclase, protein kinase and ornithine decarboxylase activity during postnatal development and maturity in the rat.
    The Journal of endocrinology, 1973, Volume: 57, Issue:2

    Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclases; Animals; Corpus Luteum; Cyclic AMP; Female; Indomethacin; Luteinizing Hormone; Ornithine; Ovarian Follicle; Ovary; Phosphotransferases; Prostaglandins; Protein Binding; Protein Kinases; Rats; Tritium

1973
Indomethacin, lipolysis, and cyclic AMP accumulation in white fat cells.
    Endocrinology, 1973, Volume: 93, Issue:3

    Topics: Adenine; Adipose Tissue; Animals; Cyclic AMP; Fatty Acids, Nonesterified; Feedback; Female; Glycerol; Hydrogen-Ion Concentration; Indomethacin; Male; Norepinephrine; Prostaglandin Antagonists; Prostaglandins; Rats; Theophylline; Tritium

1973
Effect of acute cardiac overload on intramyocardial cyclic 3',5'-AMP: relation to prostaglandin synthesis.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1974, Volume: 147, Issue:1

    Topics: Adenine; Animals; Aorta, Thoracic; Carbon Radioisotopes; Cardiomegaly; Constriction; Cyclic AMP; Depression, Chemical; Enzyme Activation; Indomethacin; Male; Mixed Function Oxygenases; Myocardium; Prostaglandins; Rats; Time Factors

1974
Effects of adenine on stored human red cells.
    Advances in experimental medicine and biology, 1972, Volume: 28

    Topics: Acids; Adenine; Adenosine Diphosphate; Adenosine Triphosphate; Blood Preservation; Blood Transfusion; Carbon Isotopes; Chromatography; Citrates; Erythrocytes; Glucose; Glycerophosphates; Humans; Indomethacin

1972
The effects of methyl mercury on platelets: induction of aggregation and release via activation of the prostaglandin synthesis pathway.
    Molecular pharmacology, 1981, Volume: 19, Issue:3

    Topics: Adenine; Arachidonic Acids; Blood Platelets; Humans; In Vitro Techniques; Indomethacin; Malondialdehyde; Methylmercury Compounds; Platelet Aggregation; Prostaglandin Endoperoxides; Prostaglandins; Thromboxanes

1981
A small molecular mass inhibitor of growth of 3T3 cells and porcine aortic smooth muscle cells released from the macrophage cell line P388D1.
    Journal of cell science, 1993, Volume: 106 ( Pt 4)

    Topics: 3T3 Cells; Adenine; Animals; Cell Division; Cells, Cultured; Culture Media, Conditioned; Cycloheximide; Dialysis; Dose-Response Relationship, Drug; Fibroblasts; Growth Inhibitors; Humans; Indomethacin; Macrophages, Peritoneal; Mice; Mitogens; Muscle, Smooth; Time Factors; Tissue Distribution

1993
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.
    European journal of pharmacology, 1997, Jul-23, Volume: 331, Issue:2-3

    Topics: Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Culture Media; Cytokines; Female; Immunohistochemistry; Indomethacin; Interferon-gamma; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Stimulation, Chemical; Tenofovir; Theophylline; Tumor Necrosis Factor-alpha

1997
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.
    Pharmaceutical research, 1998, Volume: 15, Issue:8

    Topics: Adenine; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Epithelium; Humans; Indomethacin; Verapamil

1998
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
    Molecular pharmacology, 1998, Volume: 54, Issue:5

    Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine

1998
Intravascular adenosine: the endothelial mediators of its negative dromotropic effects.
    European journal of pharmacology, 1999, Apr-01, Volume: 370, Issue:1

    Topics: Adenine; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Endothelium, Vascular; Enzyme Inhibitors; Guinea Pigs; Indomethacin; Male; Muscle, Smooth, Vascular; Neural Conduction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Vasodilator Agents

1999
Involvement of cyclooxygenase 2 in the protective effect of 17beta-estradiol on hypercholesterolemic rabbit aorta.
    Biochemical and biophysical research communications, 2000, Aug-28, Volume: 275, Issue:2

    Topics: Acetylcholine; Adenine; Animals; Aorta; Aspirin; Cholesterol; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Estradiol; Hypercholesterolemia; In Vitro Techniques; Indomethacin; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Triglycerides

2000
Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.
    International journal of molecular medicine, 2001, Volume: 7, Issue:3

    Topics: Adenine; Androstadienes; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Hydrocortisone; Indomethacin; Naphthalenes; Nifedipine; Oligopeptides; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Protein Kinase C; Pyrazoles; Pyrrolidinones; Receptors, Endothelin; Signal Transduction; Type C Phospholipases; Tyrphostins; Wortmannin; Zona Fasciculata; Zona Reticularis

2001
Monocyte membrane type 1-matrix metalloproteinase. Prostaglandin-dependent regulation and role in metalloproteinase-2 activation.
    The Journal of biological chemistry, 2001, Jun-01, Volume: 276, Issue:22

    Topics: Adenine; Adenylyl Cyclases; Blotting, Western; Bucladesine; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Humans; Indomethacin; Lipopolysaccharides; Matrix Metalloproteinase 2; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Monocytes; Prostaglandins; RNA; Tissue Inhibitor of Metalloproteinase-2

2001
Evidence for the presence of A(1) adenosine receptors in the aorta of spontaneously hypertensive rats.
    British journal of pharmacology, 2001, Volume: 134, Issue:8

    Topics: Adenine; Adenosine; Animals; Aorta; Culture Techniques; Dose-Response Relationship, Drug; Endothelium, Vascular; Free Radical Scavengers; Hypertension; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norbornanes; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Theobromine; Vasodilation

2001
Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta.
    Life sciences, 2006, Jan-18, Volume: 78, Issue:8

    Topics: Adenine; Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Drug Combinations; Flavonoids; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Potassium Chloride; Propolis; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2006
Endothelial nitric oxide attenuates Na+/Ca2+ exchanger-mediated vasoconstriction in rat aorta.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta, Thoracic; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Potassium; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Thiourea; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2008
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.
    Pharmaceutical research, 2009, Volume: 26, Issue:4

    Topics: Adenine; Administration, Cutaneous; Alanine; Animals; Caproates; Chemistry, Pharmaceutical; Dimethylamines; Dodecanol; Drug Carriers; Drug Compounding; Drug Stability; Electric Impedance; Esterases; Halogenation; Hydrocortisone; Hydrolysis; Indomethacin; Isomerism; Methylamines; Molecular Structure; Organophosphonates; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline; Time Factors

2009
Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 329, Issue:3

    Topics: Adenine; Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Blood-Brain Barrier; Brain; Cerebrospinal Fluid; Disease Models, Animal; Drug Interactions; Eflornithine; Indomethacin; Male; Melarsoprol; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Nifurtimox; Pentamidine; Perfusion; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African

2009
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
    Oral diseases, 2010, Volume: 16, Issue:8

    Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Guanidines; Indazoles; Indomethacin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Size; Ornithine; Parotid Gland; Periodontitis; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salivary Proteins and Peptides; Thiazoles

2010
Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats.
    Life sciences, 2012, Dec-17, Volume: 91, Issue:25-26

    Topics: Acetaminophen; Adenine; Administration, Oral; Analgesics, Non-Narcotic; Animals; Antioxidants; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Glutathione; Indomethacin; Kidney Failure, Chronic; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Survival Rate

2012
Vasodilator Effects of Elcatonin, a Synthetic Eel Calcitonin, on Retinal Blood Vessels in Rats.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:10

    Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Calcitonin; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats, Wistar; Retinal Vessels; Vasodilator Agents

2015
Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages.
    Journal of molecular medicine (Berlin, Germany), 2017, Volume: 95, Issue:4

    Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cell Line; Chloroquine; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gastric Mucosa; Humans; Indomethacin; Male; Microtubule-Associated Proteins; Protective Agents; Rats, Inbred WKY; RNA Interference; RNAi Therapeutics; Stomach; Stomach Ulcer

2017