adenine has been researched along with gsk2656157 in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 16 (76.19) | 24.3611 |
| 2020's | 5 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Alsaid, H; Atkins, C; Axten, JM; Choudhry, AE; Figueroa, DJ; Gaul, N; Goetz, A; Jucker, BM; Kumar, R; Liu, Q; Minthorn, E; Moss, K; Sanders, B; Stanley, TB; Zhang, SY | 1 |
| Kesoglidou, P; Koromilas, AE; Krishnamoorthy, J; Mirzajani, F; Papadakis, AI; Rajesh, K | 1 |
| Chang, HC; Chang, X; Chen, S; Chen, Y; Dang, Y; Deng, M; Dong, M; Dong, Z; Fu, C; Gao, L; Huang, Q; Jia, XE; Jin, Y; Jing, C; Li, L; Liu, K; Luo, L; Ma, K; Pan, W; Ren, C; Wang, Z; Wu, S; Xu, T; Zhang, W; Zhou, Y; Zhu, J; Zon, LI | 1 |
| Lv, S; Sun, EC; Wu, DL; Xu, QY; Zhang, JK | 1 |
| Ando, T; Koide, N; Komatsu, T; Naiki, Y; Takahashi, K; Watanabe, D; Yokochi, T | 1 |
| Chen, Y; Liu, B; Xia, J; Zhang, J | 1 |
| Banie, L; Lin, G; Lue, TF; Ning, H; Oh, BS; Reed-Maldonado, AB; Ruan, Y; Wang, B; Wang, HS; Zhou, J; Zhou, T | 1 |
| Cabral-Miranda, F; Duran-Aniotz, C; Hetz, C; Martínez, G; Vivar, JP | 1 |
| Augustyns, K; Bertrand, MJM; Delvaeye, T; Nerinckx, W; Roelandt, R; Rojas-Rivera, D; Vandenabeele, P | 1 |
| Che, X; Fan, P; He, Z; Jiang, D; Liang, Y; Liu, L; Sun, X; Tan, G; Xiang, X; Zhang, H; Zhao, J; Zhao, Q | 1 |
| Banie, L; Lin, G; Lu, Z; Lue, TF; Ning, H; Oh, BS; Qi, SL; Reed-Maldonado, AB; Ruan, Y; Wang, B; Wang, G; Wang, HS; Zhou, J; Zhou, T | 1 |
| Liu, KS; Wang, SQ; Wang, SX; Wang, X; Xie, CH; Zheng, K | 1 |
| Jang, JY; Jung, HS; Kim, MJ; Kim, MN; Kim, SW; Lee, H; Min, SH; Park, KS; Shin, SY | 1 |
| Huangpu, H; Sun, J; Yao, F; Yu, X | 1 |
| Ham, DS; Jung, HS; Kim, JW; Kim, MJ; Kim, MN; Min, SH; Park, KS; Yoon, KH | 1 |
| Backes, BJ; Ghosh, R; Gliedt, MJ; Hiniker, A; Kim, GE; Maly, DJ; Meza-Acevedo, R; Moore, PC; Oakes, SA; Papa, FR; Peng, J; Qi, JY; Thamsen, M; Warren, RE | 1 |
| Feng, Y; Gao, Y; Wang, Q; Zhang, C; Zhu, H | 1 |
| Hasebe, A; Koido, M; Okamoto, Y; Saito, T; Tani, Y; Toki, T; Tomida, A | 1 |
| Dolan, BP; Godil, J; Nagamine, BS | 1 |
| Li, Z; Liu, D; Lu, J; Mei, YA; Zhao, Q | 1 |
| Au-Yeung, RK; Cai, JP; Chan, JF; Chu, H; Hou, Y; Hu, B; Huang, X; Jin, DY; Kok, KH; Li, C; Perlman, S; Poon, VK; Shuai, H; Wang, Y; Wen, L; Wong, BH; Wong, KK; Yang, D; Yeung, ML; Yoon, C; Yuan, S; Yuen, KY; Zhang, X; Zhao, X; Zhou, J | 1 |
1 review(s) available for adenine and gsk2656157
| Article | Year |
|---|---|
Endoplasmic reticulum proteostasis impairment in aging.
Topics: Adenine; Aging; Animals; Brain; Caenorhabditis elegans; Drosophila melanogaster; Endoplasmic Reticulum Stress; Guanabenz; Humans; Indoles; Neurodegenerative Diseases; Neurons; Protective Agents; Proteome; Proteostasis; Proteostasis Deficiencies; Saccharomyces cerevisiae; Unfolded Protein Response | 2017 |
20 other study(ies) available for adenine and gsk2656157
| Article | Year |
|---|---|
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.
Topics: Adenine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; eIF-2 Kinase; Female; Gene Expression Profiling; Indoles; Mice; Protein Kinase Inhibitors | 2013 |
Evidence for eIF2α phosphorylation-independent effects of GSK2656157, a novel catalytic inhibitor of PERK with clinical implications.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Death; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Humans; Indoles; Mice; Phosphorylation; Protein Kinase Inhibitors | 2014 |
Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction.
Topics: Adenine; Animals; Autophagy; eIF-2 Kinase; Hematopoiesis; Hematopoietic Stem Cells; Indoles; Mutation; Organelle Biogenesis; Protein Kinase Inhibitors; Ribosomes; Zebrafish; Zebrafish Proteins | 2015 |
Endoplasmic reticulum stress-mediated autophagy contributes to bluetongue virus infection via the PERK-eIF2α pathway.
Topics: Adenine; Animals; Autophagy; Bluetongue virus; Capsid Proteins; Cells, Cultured; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Gene Knockdown Techniques; Heat-Shock Proteins; Indoles; Models, Biological; Signal Transduction; Unfolded Protein Response; Virus Replication | 2015 |
GSK2656157, a PERK inhibitor, reduced LPS-induced IL-1β production through inhibiting Caspase 1 activation in macrophage-like J774.1 cells.
Topics: Adenine; Animals; Caspase 1; Cell Line; eIF-2 Kinase; Enzyme Activation; Indoles; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice | 2016 |
Sevoflurane-Induced Endoplasmic Reticulum Stress Contributes to Neuroapoptosis and BACE-1 Expression in the Developing Brain: The Role of eIF2α.
Topics: Activating Transcription Factor 4; Adenine; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Aspartic Acid Endopeptidases; Caspase 3; Cerebral Cortex; Cinnamates; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Indoles; Methyl Ethers; Mice; Phosphorylation; Sevoflurane; Signal Transduction; Thiourea; Transcription Factor CHOP | 2017 |
Low-Intensity Extracorporeal Shock Wave Therapy Enhances Brain-Derived Neurotrophic Factor Expression through PERK/ATF4 Signaling Pathway.
Topics: Activating Transcription Factor 4; Adenine; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; eIF-2 Kinase; Gene Silencing; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Male; Penis; Peripheral Nerve Injuries; Phosphorylation; Rats; Schwann Cells; Signal Transduction; Ultrasonic Waves | 2017 |
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.
Topics: Adenine; Animals; Apoptosis; Cell Line; eIF-2 Kinase; Indoles; Mice; Receptor-Interacting Protein Serine-Threonine Kinases; Unfolded Protein Response | 2017 |
Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage.
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blood-Brain Barrier; Brain Edema; Carrier Proteins; Cell Cycle Proteins; Encephalitis; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Gene Expression Regulation; Indoles; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Resveratrol; RNA, Small Interfering; Signal Transduction; Stilbenes; Subarachnoid Hemorrhage; Sulfonamides; Thiophenes | 2017 |
Low-intensity extracorporeal shock wave therapy promotes myogenesis through PERK/ATF4 pathway.
Topics: Activating Transcription Factor 4; Adenine; Animals; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Extracorporeal Shockwave Therapy; Indoles; Muscle Development; Myoblasts; Phosphorylation; Rats; Rats, Zucker; Signal Transduction; Stem Cells | 2018 |
Simultaneous targeting PI3K and PERK pathways promotes cell death and improves the clinical prognosis in esophageal squamous carcinoma.
Topics: Adenine; Aged; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; China; eIF-2 Kinase; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Humans; Indoles; Male; Middle Aged; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prevalence; Prognosis; Signal Transduction; Survival Rate; Treatment Outcome | 2017 |
Attenuation of PERK enhances glucose-stimulated insulin secretion in islets.
Topics: Adenine; Animals; Calcium; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Female; Gene Expression; Glucose; Heat-Shock Proteins; Humans; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phosphorylation | 2018 |
Ginsenoside Rb3 protects cardiomyocytes against hypoxia/reoxygenation injury via activating the antioxidation signaling pathway of PERK/Nrf2/HMOX1.
Topics: Adenine; Animals; Antioxidants; Cardiotonic Agents; Cell Hypoxia; Cell Line; Dose-Response Relationship, Drug; eIF-2 Kinase; Ginsenosides; Heme Oxygenase (Decyclizing); Indoles; Male; Myocytes, Cardiac; NF-E2-Related Factor 2; Oxidative Stress; Panax; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction | 2019 |
Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes.
Topics: Adenine; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; eIF-2 Kinase; Glucose; Hyperglycemia; Indoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Palmitates; Sulfonylurea Compounds | 2019 |
Parallel Signaling through IRE1α and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Topics: Adenine; Animals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum Stress; Endoribonucleases; Female; Humans; Indoles; Mice; Mice, Transgenic; Neuroendocrine Tumors; Pancreatic Neoplasms; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Signal Transduction; Unfolded Protein Response; Xenograft Model Antitumor Assays | 2019 |
Inhibition of PERK Signaling Prevents Against Glucocorticoid-induced Endotheliocyte Apoptosis and Osteonecrosis of the Femoral Head.
Topics: Adenine; Animals; Apoptosis; Blotting, Western; Endoplasmic Reticulum Stress; Femur Head; Femur Head Necrosis; Glucocorticoids; Immunohistochemistry; Indoles; Rats; Rats, Sprague-Dawley; Signal Transduction | 2020 |
The kinase PERK represses translation of the G-protein-coupled receptor LGR5 and receptor tyrosine kinase ERBB3 during ER stress in cancer cells.
Topics: Adenine; Cell Line, Tumor; Deoxyglucose; Down-Regulation; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glycosylation; Half-Life; Heat-Shock Proteins; Humans; Indoles; Mucoproteins; Oncogene Proteins; Phosphorylation; Receptor, ErbB-3; Receptors, G-Protein-Coupled; RNA Interference; RNA, Small Interfering; Unfolded Protein Response | 2020 |
The Unfolded Protein Response Reveals eIF2α Phosphorylation as a Critical Factor for Direct MHC Class I Antigen Presentation.
Topics: Adenine; Animals; Antigen Presentation; Cell Line; Cinnamates; Endoribonucleases; Eukaryotic Initiation Factor-2; Humans; Hymecromone; Indoles; Mice; Phosphorylation; Protein Serine-Threonine Kinases; RNA, Messenger; Signal Transduction; Thiourea; Unfolded Protein Response; X-Box Binding Protein 1 | 2021 |
Neuritin improves the neurological functional recovery after experimental intracerebral hemorrhage in mice.
Topics: Adenine; Animals; Brain; Cerebral Hemorrhage; Dependovirus; Excitatory Postsynaptic Potentials; Furans; GPI-Linked Proteins; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Organ Culture Techniques; Pyridines; Pyrimidines; Recovery of Function | 2021 |
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity.
Topics: Adenine; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Apoptosis; Cell Line; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dipeptidyl Peptidase 4; eIF-2 Kinase; Epithelial Cells; Female; Humans; Indoles; Lung; Male; Mice, Transgenic | 2021 |