adenine and galidesivir

adenine has been researched along with galidesivir in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (11.43)	29.6817
2010's	23 (65.71)	24.3611
2020's	8 (22.86)	2.80

Authors

Authors	Studies
Almo, SC; Deng, H; Evans, GB; Furneaux, RH; Ghanem, M; Gupta, A; Rinaldo-Matthis, A; Schramm, VL; Tyler, PC; Wang, CC; Wing, C; Wu, P	1
Delso, I; Merino, P; Tejero, T	1
Clinch, K; Evans, GB; Fröhlich, RF; Furneaux, RH; Kelly, PM; Legentil, L; Li, L; Murkin, AS; Schramm, VL; Tyler, PC; Woolhouse, AD	1
Lewis, AW; Neuendorff, DA; Randel, RD; Weems, CW; Weems, YS	1
Furneaux, RH; Gainsford, GJ; Sauve, A; Shramm, VL; Tyler, PC	1
Basu, I; Belbin, TJ; Cassera, MB; Dong, X; Evans, GB; Guha, C; Hemeon, I; Locker, J; Merino, EF; Schramm, VL	1
Motley, MW; Schramm, VL; Schwartz, SD	1
Burgos, ES; Kamat, SS; Raushel, FM	1
Babu, YS; Bantia, S; Bavari, S; Chen, X; Dong, L; Eaton, BP; Garza, NL; Honnold, S; Kotian, P; Minning, DM; Panchal, RG; Pegoraro, G; Retterer, CJ; Sheridan, WP; Stuthman, KS; Taubenheim, BR; Van Tongeren, SA; Warren, TK; Welch, LS; Wells, J	1
Harrington, M	1
Babu, YS; Bantia, S; Julander, JG; Kotian, P; Minning, DM; Morrey, JD; Sheridan, WP; Smee, DF; Taubenheim, BR	1
Bavari, S; Cardile, AP; Mayers, DL	1
Bekerman, E; Einav, S	1
Clinch, K; Evans, GB; Freitas, EO; Guan, R; Meyer-Fernandes, JR; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC	1
Evans, GB; Schramm, VL; Tyler, PC	1
De Clercq, E	1
Alves-Silva, MV; Clinch, K; Evans, GB; Freitas, EO; Morrot, A; Nico, D; Palatnik-de-Sousa, CB; Schramm, VL; Tyler, PC	1
de Lamballerie, X; Guedj, J; Madelain, V; Mentré, F; Nguyen, TH; Olivo, A; Taburet, AM	1
Naik, SY; Setlur, AS; Skariyachan, S	1
Apuli, C; Babu, YS; Collins, P; Evans, J; Gebre, M; Julander, JG; Lee, YM; Morrey, JD; Neilson, S; Sheridan, WP; Siddharthan, V; Stewart, J; Taylor, R; Tolbert, K; Van Wettere, A	1
Bavari, S; Cardile, AP; Martins, KA; Reisler, RB; Warren, TK	1
de Clercq, E; Eyer, L; Fojtíková, M; Haviernik, J; Nencka, R; Růžek, D; Širmarová, J; Štefánik, M; Zouharová, D	1
Khan, A; Khan, H; Khan, S; Mahasneh, AM; Mubarak, MS; Patel, S; Rauf, A; Rizwan, M	1
Amorim, CF; Carvalho, NB; Corte, TWF; da Silva, RC; de Carvalho, EM; de Oliveira Prates, FV; Dourado, MEF; Machado, P; Machado, PRL; Pacheco, FG; Santos, DS	1
Jochmans, D; Neyts, J	1
Bailey, KW; Gowen, BB; Hickerson, BT; Jung, KH; Mathis, A; Sefing, EJ; Sheridan, WP; Taylor, R; Wandersee, L; Westover, JB	1
De Clercq, E; de Lamballerie, X; Driouich, JS; Eyer, L; Gould, EA; Haviernik, J; Nougairède, A; Ruzek, D; Uhlířová, M; Valdés, JJ; Zouharová, D	1
Lin, SX; Stephen, P; Thériault, JF; Wang, R; Zhang, WF	1
Carvalho Junior, RN; J C Neto, AM; Martins, AY; Reis, AF; S Costa, JF; Silva Arouche, TD	1
Celik, I; Duzgun, Z; Erol, M	1
D'Alonzo, D; De Fenza, M; Esposito, A; Guaragna, A	1
Babu, YS; Demarest, JF; Gowen, BB; Julander, JG; Mathis, A; Taylor, R; Walling, DM	1
Assis, LC; da Cunha, EFF; de Almeida La Porta, F; de Castro Ramalho, T; de Castro, AA; de Jesus, JPA; Kuca, K; Nepovimova, E	1
Babu, YS; Bielefeldt-Ohmann, H; Bowen, R; Demarest, JF; DeSpirito, M; Hartwig, A; Mathis, A; Taylor, R; Walling, DM	1
Collins, D; Dobo, S; Mathis, A; Sheridan, WP; Taylor, R; Walling, DM	1

Reviews

9 review(s) available for adenine and galidesivir

Article	Year
Current developments in the synthesis and biological activity of aza-C-nucleosides: immucillins and related compounds. Current medicinal chemistry, 2008, Volume: 15, Issue:10 Topics: Adenine; Adenosine; Aza Compounds; Glycoside Hydrolases; N-Glycosyl Hydrolases; Nucleosides; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Pyrroles; Pyrrolidines	2008
Current status of chemically synthesized inhibitors of Ebola virus. Recent patents on anti-infective drug discovery, 2014, Volume: 9, Issue:2 Topics: Adenine; Adenosine; Amides; Antiviral Agents; Cytosine; Drug Discovery; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Organophosphonates; Patents as Topic; Purine Nucleosides; Pyrazines; Pyrrolidines	2014
The Immucillins: Design, Synthesis and Application of Transition- State Analogues. Current medicinal chemistry, 2015, Volume: 22, Issue:34 Topics: Adenine; Adenosine; Animals; Enzyme Inhibitors; Humans; N-Glycosyl Hydrolases; Protein Binding; Purine-Nucleoside Phosphorylase; Pyrrolidines; Substrate Specificity; Thermodynamics	2015
C-Nucleosides To Be Revisited. Journal of medicinal chemistry, 2016, Mar-24, Volume: 59, Issue:6 Topics: Adenine; Adenosine; Alanine; Animals; Antineoplastic Agents; Antiviral Agents; Humans; Nucleosides; Nucleotides; Pseudouridine; Purine Nucleosides; Pyrrolidines; Triazines	2016
Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials. Clinical pharmacokinetics, 2016, Volume: 55, Issue:8 Topics: Adenine; Adenosine; Amides; Animals; Antiviral Agents; Disease Outbreaks; Ebolavirus; Healthy Volunteers; Hemorrhagic Fever, Ebola; Humans; Models, Animal; Purine Nucleosides; Pyrazines; Pyrrolidines	2016
Will There Be a Cure for Ebola? Annual review of pharmacology and toxicology, 2017, 01-06, Volume: 57 Topics: Adenine; Adenosine; Adenosine Monophosphate; Africa, Western; Alanine; Animals; Antiviral Agents; Disease Outbreaks; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Purine Nucleosides; Pyrrolidines; Ribonucleotides	2017
Comprehensive Review on Ebola (EBOV) Virus: Future Prospects. Infectious disorders drug targets, 2018, Volume: 18, Issue:2 Topics: Adenine; Adenosine; Africa, Western; Animals; Antiviral Agents; Disease Outbreaks; Drug Discovery; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Immune System; Purine Nucleosides; Pyrrolidines; Virus Replication	2018
The path towards effective antivirals against rabies. Vaccine, 2019, 08-02, Volume: 37, Issue:33 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Drug Repositioning; Humans; Post-Exposure Prophylaxis; Pyrazines; Pyrrolidines; Rabies; Rabies virus	2019
An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral. Antiviral research, 2021, Volume: 195 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Clinical Trials, Phase I as Topic; Drug Evaluation, Preclinical; Marburgvirus; Nucleosides; Pyrrolidines; SARS-CoV-2	2021

Trials

1 trial(s) available for adenine and galidesivir

Article	Year
Pharmacokinetics and Safety of the Nucleoside Analog Antiviral Drug Galidesivir Administered to Healthy Adult Subjects. Clinical pharmacology in drug development, 2022, Volume: 11, Issue:4 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Healthy Volunteers; Humans; Nucleosides; Pyrrolidines; Zika Virus; Zika Virus Infection	2022

Other Studies

25 other study(ies) available for adenine and galidesivir

Article	Year
Inhibition and structure of Trichomonas vaginalis purine nucleoside phosphorylase with picomolar transition state analogues. Biochemistry, 2007, Jan-23, Volume: 46, Issue:3 Topics: Adenine; Adenosine; Animals; Catalytic Domain; Crystallization; Crystallography, X-Ray; Models, Molecular; Purine-Nucleoside Phosphorylase; Pyrrolidines; Substrate Specificity; Trichomonas vaginalis	2007
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. Journal of medicinal chemistry, 2009, Feb-26, Volume: 52, Issue:4 Topics: Adenine; Adenosine; Catalytic Domain; Drug Design; Humans; Molecular Conformation; Pliability; Protein Binding; Purine-Nucleoside Phosphorylase; Pyrrolidines; Structure-Activity Relationship	2009
Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro. Prostaglandins & other lipid mediators, 2009, Volume: 90, Issue:3-4 Topics: Adenine; Adenosine; Animals; Arachidonic Acids; Cattle; Corpus Luteum; Dinoprost; Dinoprostone; Female; In Vitro Techniques; Indoles; Organophosphonates; Piperidines; Pregnancy; Progesterone; Pyrazoles; Pyrrolidines; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2	2009
A synchrotron radiation study of the one-dimensional complex of sodium with (1S)-N-carboxylato-1-(9-deazaadenin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol, a member of the 'immucillin' family. Acta crystallographica. Section C, Crystal structure communications, 2010, Volume: 66, Issue:Pt 3 Topics: Adenine; Adenosine; Crystallography, X-Ray; Hydrogen Bonding; Molecular Conformation; Polymers; Pyrrolidines; Radiation; Ribitol; Sodium; Stereoisomerism; Synchrotrons	2010
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase. The Journal of biological chemistry, 2011, Feb-11, Volume: 286, Issue:6 Topics: Adenine; Adenosine; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Deoxyadenosines; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Purine-Nucleoside Phosphorylase; Pyrrolidines; S-Adenosylmethionine; Thionucleosides; Transplantation, Heterologous; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays	2011
Conformational freedom in tight binding enzymatic transition-state analogues. The journal of physical chemistry. B, 2013, Aug-22, Volume: 117, Issue:33 Topics: Adenine; Adenosine; Bacteria; Bacterial Proteins; Binding Sites; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Molecular Dynamics Simulation; N-Glycosyl Hydrolases; Protein Binding; Pyrrolidines; Vibrio cholerae	2013
Potent inhibition of the C-P lyase nucleosidase PhnI by Immucillin-A triphosphate. Biochemistry, 2013, Oct-22, Volume: 52, Issue:42 Topics: Adenine; Adenosine; Adenosine Triphosphate; Catalysis; Escherichia coli; Escherichia coli Proteins; Lyases; Magnesium; Models, Chemical; Organophosphonates; Pentosephosphates; Polyphosphates; Pyrrolidines	2013
Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430. Nature, 2014, Apr-17, Volume: 508, Issue:7496 Topics: Adenine; Adenosine; Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; DNA-Directed RNA Polymerases; Ebolavirus; Filoviridae; Filoviridae Infections; Hemorrhagic Fever, Ebola; Humans; Injections, Intramuscular; Macaca fascicularis; Marburg Virus Disease; Marburgvirus; Purine Nucleosides; Pyrrolidines; RNA; Time Factors	2014
Small molecule, big advance against Marburg virus. Lab animal, 2014, Apr-21, Volume: 43, Issue:5 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Bunyaviridae; Disease Models, Animal; Filoviridae; Guinea Pigs; Humans; Macaca fascicularis; Marburg Virus Disease; Marburgvirus; Mice; Purine Nucleosides; Pyrrolidines	2014
BCX4430, a novel nucleoside analog, effectively treats yellow fever in a Hamster model. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:11 Topics: Adenine; Adenosine; Alanine Transaminase; Animals; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; Cells, Cultured; Cricetinae; Disease Models, Animal; Female; Mesocricetus; Purine Nucleosides; Pyrrolidines; Treatment Outcome; Viral Plaque Assay; Viremia; Yellow Fever; Yellow fever virus	2014
Infectious disease. Combating emerging viral threats. Science (New York, N.Y.), 2015, Apr-17, Volume: 348, Issue:6232 Topics: Adenine; Adenosine; Antiviral Agents; Benzamides; Chloroquine; Communicable Diseases, Emerging; Cyclosporins; Cytosine; Dengue; Drug Approval; Drug Design; Erlotinib Hydrochloride; Hemorrhagic Fever, Ebola; Humans; Imatinib Mesylate; Indoles; Organophosphonates; Piperazines; Purine Nucleosides; Pyrimidines; Pyrroles; Pyrrolidines; Quinazolines; Sunitinib; Viruses	2015
Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro. PloS one, 2015, Volume: 10, Issue:4 Topics: Adenine; Adenosine; Animals; Antiprotozoal Agents; Cell Proliferation; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Leishmania infantum; Leishmania mexicana; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; N-Glycosyl Hydrolases; Purine Nucleosides; Pyrimidinones; Pyrroles; Pyrrolidines	2015
Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis. PLoS neglected tropical diseases, 2015, Volume: 9, Issue:12 Topics: Adenine; Adenosine; Animals; Antibodies, Protozoan; Antiprotozoal Agents; Blood Chemical Analysis; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Female; Gene Expression; Immunophenotyping; Interferon-gamma; Interleukin-10; Leishmania; Leishmaniasis, Visceral; Leukocytes, Mononuclear; Mesocricetus; Mice, Inbred BALB C; Parasite Load; Purine Nucleosides; Pyrimidinones; Pyrrolidines; Spleen; T-Lymphocyte Subsets; Treatment Outcome; Tumor Necrosis Factor-alpha	2015
Herbal Lead as Ideal Bioactive Compounds Against Probable Drug Targets of Ebola Virus in Comparison with Known Chemical Analogue: A Computational Drug Discovery Perspective. Interdisciplinary sciences, computational life sciences, 2017, Volume: 9, Issue:2 Topics: Adenine; Adenosine; Antiviral Agents; Drug Discovery; Ebolavirus; Humans; Molecular Docking Simulation; Purine Nucleosides; Pyrrolidines; Transcription Factors; Viral Matrix Proteins; Viral Proteins; Viral Regulatory and Accessory Proteins	2017
Efficacy of the broad-spectrum antiviral compound BCX4430 against Zika virus in cell culture and in a mouse model. Antiviral research, 2017, Volume: 137 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Brain; Cell Line; Disease Models, Animal; Humans; Male; Mice; Purine Nucleosides; Pyrrolidines; RNA, Viral; Testis; Viral Load; Viremia; Virus Replication; Zika Virus; Zika Virus Infection	2017
Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses. Antiviral research, 2017, Volume: 142 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Culicidae; Dose-Response Relationship, Drug; Encephalitis Viruses, Tick-Borne; Encephalitis, Tick-Borne; Flavivirus; Purine Nucleosides; Pyrrolidines; Swine; Tick-Borne Diseases; Ticks; Vero Cells; Virus Replication; West Nile virus	2017
Journal of immunology research, 2017, Volume: 2017 Topics: Adenine; Adenosine; Brazil; Cell Proliferation; Cells, Cultured; Cytokines; Humans; Immunomodulation; Killer Cells, Natural; Leishmania braziliensis; Leishmaniasis, Cutaneous; Leukocytes, Mononuclear; Lymphocyte Activation; Purine-Nucleoside Phosphorylase; Pyrrolidines; Th1 Cells	2017
Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters. Antiviral research, 2018, Volume: 156 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Disease Models, Animal; Injections, Intramuscular; Injections, Intraperitoneal; Liver; Mesocricetus; Purine Nucleosides; Pyrrolidines; Rift Valley Fever; Rift Valley fever virus; Spleen; Survival Analysis; Treatment Outcome	2018
An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. Journal of virology, 2019, 08-15, Volume: 93, Issue:16 Topics: Adenine; Adenosine; Alleles; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Resistance, Microbial; Drug Resistance, Viral; Encephalitis Viruses, Tick-Borne; Encephalitis, Tick-Borne; Genotype; Mice; Mutation; Pyrrolidines; Viral Nonstructural Proteins	2019
Novel Coronavirus Polymerase and Nucleotidyl-Transferase Structures: Potential to Target New Outbreaks. The journal of physical chemistry letters, 2020, Jun-04, Volume: 11, Issue:11 Topics: Adenine; Adenosine; Amides; Antiviral Agents; Betacoronavirus; Binding Sites; Coronavirus Infections; COVID-19; Humans; Molecular Docking Simulation; Nucleotidyltransferases; Pandemics; Pneumonia, Viral; Protein Structure, Tertiary; Pyrazines; Pyrrolidines; RNA-Dependent RNA Polymerase; SARS-CoV-2	2020
Interactions Between Remdesivir, Ribavirin, Favipiravir, Galidesivir, Hydroxychloroquine and Chloroquine with Fragment Molecular of the COVID-19 Main Protease with Inhibitor N3 Complex (PDB ID:6LU7) Using Molecular Docking. Journal of nanoscience and nanotechnology, 2020, 12-01, Volume: 20, Issue:12 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Betacoronavirus; Binding Sites; Chloroquine; Coronavirus 3C Proteases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cysteine Endopeptidases; Drug Interactions; Humans; Hydrogen Bonding; Hydroxychloroquine; Ligands; Molecular Docking Simulation; Nanotechnology; Pandemics; Pneumonia, Viral; Protease Inhibitors; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Static Electricity; Viral Nonstructural Proteins	2020
In silico evaluation of potential inhibitory activity of remdesivir, favipiravir, ribavirin and galidesivir active forms on SARS-CoV-2 RNA polymerase. Molecular diversity, 2022, Volume: 26, Issue:1 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; COVID-19 Drug Treatment; Drug Repositioning; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Pyrazines; Pyrrolidines; Ribavirin; RNA, Viral; SARS-CoV-2	2022
Synthesis of Piperidine Nucleosides as Conformationally Restricted Immucillin Mimics. Molecules (Basel, Switzerland), 2021, Mar-16, Volume: 26, Issue:6 Topics: Adenine; Adenosine; Magnetic Resonance Spectroscopy; Molecular Conformation; Nucleosides; Piperidines; Purine Nucleosides; Pyrimidinones; Pyrrolidines; Structure-Activity Relationship	2021
Effect of drug metabolism in the treatment of SARS-CoV-2 from an entirely computational perspective. Scientific reports, 2021, 10-07, Volume: 11, Issue:1 Topics: Adenine; Adenosine; Adenosine Monophosphate; Alanine; Amides; Antiviral Agents; Chloroquine; COVID-19; COVID-19 Drug Treatment; Drug Design; Drug Discovery; Humans; Metabolic Networks and Pathways; Molecular Docking Simulation; Nitro Compounds; Pyrazines; Pyrrolidines; Ribavirin; SARS-CoV-2; Thiazoles	2021
Activity of Galidesivir in a Hamster Model of SARS-CoV-2. Viruses, 2021, 12-21, Volume: 14, Issue:1 Topics: Adenine; Adenosine; Animals; Antiviral Agents; Cell Line; COVID-19; COVID-19 Drug Treatment; Cricetinae; Disease Models, Animal; Humans; Lung; Mesocricetus; Pyrrolidines; SARS-CoV-2; Viral Load	2021