adenine and cidofovir anhydrous

adenine has been researched along with cidofovir anhydrous in 77 studies

Research

Studies (77)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.30)	18.7374
1990's	33 (42.86)	18.2507
2000's	32 (41.56)	29.6817
2010's	11 (14.29)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Andrei, G; Cloes, JM; De Clercq, E; Piette, J; Rentier, B; Sadzot-Delvaux, C; Schols, D; Snoeck, R	1
Andrei, G; De Clercq, E; Desmyter, J; Goubau, P; Snoeck, R	1
Andrei, G; De Clercq, E; Neyts, J; Schols, D; Snoeck, R	1
De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE	1
De Clercq, E; Maudgal, PC	1
Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I	1
Araullo-Cruz, T; De Clercq, E; Erzurum, S; Gordon, YJ; Romanowski, E; Seaberg, L; Tolman, R	1
De Clercq, E	11
Baba, M; De Clercq, E; Konno, K; Shigeta, S; Yokota, T	1
Bronson, JJ; De Boeck, H; Ghazzouli, I; Hitchcock, MJ; Ho, HT; Martin, JC; Woods, K	1
Kim, CU; Luh, BY; Martin, JC	1
Balzarini, J; Bron, D; De Clercq, E; Delforge, A; Lagneaux, L; Snoeck, R; Stryckmans, P; Van der Auwera, P	1
Aduma, P; Connelly, MC; Fridland, A; Srinivas, RV	1
De Clercq, E; Kaminsky, R; Zweygarth, E	1
De Clercq, E; Neyts, J	3
Bílá, V; Holý, A; Jelínek, R; Kren, V; Mejsnarová, B; Otová, B; Sladká, M	1
Awan, AR; Field, HJ	1
Franková, D; Holý, A; Otová, B; Zídek, A	1
Balzarini, J; De Clercq, E; Dvoráková, H; Holý, A; Naesens, L; Reymen, D	1
Balzarini, J; De Clercq, E; Naesens, L	1
De Clercq, E; Kodama, E; Shigeta, S; Suzuki, T	1
Andrei, G; De Clercq, E; Snoeck, R	2
de Clercq, E; De Hauwere, B; Lutz, A; Maudgal, PC; Neyts, J	1
Connely, M; Fridland, A; Srinivas, RV	1
Cundy, KC	1
Balzarini, J; de Clercq, E; de Vries, E; Franssen, FF; Holý, A; Naesens, L; Overdulve, JP; Smeijsters, LJ	1
Cihlar, T; Fuller, MD; Lin, DC; Mendel, DB; Pritchard, JB; Sweet, DH	1
Cihlar, T; Ho, ES; Lin, DC; Mendel, DB	1
Hoffman, VF; Skiest, DJ	1
Cadman, J	1
Miller, DS	1
Murono, S; Pagano, JS; Raab-Traub, N	1
Kern, ER	1
Hitchcock, MJ; Holý, A; Keith, KA; Kern, ER; Lee, WA	1
Beadle, JR; Ciesla, SL; Gustin, KM; Hartline, CB; Hostetler, KY; Kern, ER; Wan, WB	1
Joannidis, M	1
Bleasby, K; Hall, LA; Mohrenweiser, HW; Perry, JL; Pritchard, JB	1
Morton, CJ; Ng, HL; Parker, MW; Rawlinson, WD; Scott, GM	1
Andrei, G; Dal Pozzo, F; De Clercq, E; Holy, A; Scagliarini, A; Snoeck, R; Van Den Oord, J	1
Andrei, G; Beadle, JR; Dal Pozzo, F; De Clercq, E; Hostetler, KY; Lebeau, I; Snoeck, R; van den Oord, J	1
Liu, K; Xie, L	1
Andrei, G; Beadle, JR; Dal Pozzo, F; De Clercq, E; Hostetler, KY; Lebeau, I; Snoeck, R	1
Croubels, S; De Backer, P; Garré, B; Nauwynck, H; Neyts, J; Nugent, J; van der Meulen, K	1
Aldern, KA; Beadle, JR; Hartline, CB; Hostetler, KY; Keith, KA; Kern, ER; Ruiz, JC	1
Ida, H; Inui, K; Katsura, T; Tsuji, Y; Uwai, Y	1
Andrei, G; De Clercq, E; Fiten, P; Froeyen, M; Opdenakker, G; Snoeck, R	1
Andrei, G; Crance, JM; De Clercq, E; De Vos, R; Duraffour, S; Garin, D; Holy, A; Krecmerová, M; Snoeck, R; van Den Oord, J	1
Aldern, KA; Evans, DH; Hostetler, KY; Magee, WC	1
Beadle, JR; Collins, DJ; Hartline, CB; Hostetler, KY; Kern, ER; Pettway, LR; Quenelle, DC; Wan, WB	1
Alvarez, K; Barral, K; Bussetta, C; Canard, B; Deval, J; Frangeul, A	1
Beadle, JR	1
Carey, AC; Cihlar, T; Fisher, R; Laflamme, G; Mackman, R; Ray, AS; Vela, JE	1
Smee, DF	1
Balzarini, J; De Clercq, E; Koszytkowska-Stawińska, M	1
Holý, A; Kasicka, V; Sázelová, P; Solínová, V	1
Beadle, JR; Buller, RM; Hostetler, KY; Keith, KA; Lewis, KC; Prichard, MN; Ruiz, J; Schreiwer, J	1
Andrei, G; Balzarini, J; Dračínský, M; Holý, A; Krečmerová, M; Snoeck, R; Tichý, T	1
Borysko, KZ; Breitenbach, JM; Collins, M; Drach, JC; Hilfinger, JM; Kashemirov, BA; Krylov, IS; McKenna, CE; Peterson, LW; Serpi, M; Zakharova, VM	1
Hostetler, KY; Ray, AS	1
Leach, KL; Piotrowski, M; Wang, R; Zhang, H; Zhang, X	1
Hilgendorf, C; Jansen, K; Masereeuw, R; Nieskens, TT; Peters, JG; Röring, M; Schreurs, MJ; Smits, N; van der Made, TK; Wilmer, MJ; Woestenenk, R	1
Krecmerova, M	1
Kaltashov, IA; Xu, S	1

Reviews

19 review(s) available for adenine and cidofovir anhydrous

Article	Year
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues. International journal of immunopharmacology, 1991, Volume: 13 Suppl 1 Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA, Viral; Humans; Organophosphonates; Organophosphorus Compounds	1991
Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines. Biochemical pharmacology, 1991, Aug-08, Volume: 42, Issue:5 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; DNA, Viral; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Virus Replication	1991
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents. Drugs under experimental and clinical research, 1990, Volume: 16, Issue:7 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Retroviridae Infections; Virus Diseases	1990
Biochemical pharmacology of acyclic nucleotide analogues. Annals of the New York Academy of Sciences, 1990, Volume: 616 Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; HIV; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds	1990
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents. Postepy biochemii, 1995, Volume: 41, Issue:5 Suppl Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Stereoisomerism	1995
Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections. Intervirology, 1997, Volume: 40, Issue:5-6 Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cidofovir; Cytosine; DNA Virus Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections	1997
Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clinical pharmacokinetics, 1999, Volume: 36, Issue:2 Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Drug Interactions; Humans; Infusions, Intravenous; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Insufficiency	1999
Therapeutic developments in cytomegalovirus retinitis. Expert opinion on investigational drugs, 2000, Volume: 9, Issue:2 Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Drugs, Investigational; Foscarnet; Ganciclovir; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valganciclovir	2000
In vitro activity of potential anti-poxvirus agents. Antiviral research, 2003, Volume: 57, Issue:1-2 Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Mice; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Virus Replication	2003
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clinical microbiology reviews, 2003, Volume: 16, Issue:4 Topics: Adenine; Animals; Cidofovir; Cytosine; DNA Virus Infections; DNA Viruses; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Reverse Transcriptase Inhibitors; Tenofovir	2003
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections. Expert review of anti-infective therapy, 2003, Volume: 1, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; DNA Virus Infections; Drug Resistance, Viral; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Tenofovir	2003
Drug-induced renal failure in the ICU. The International journal of artificial organs, 2004, Volume: 27, Issue:12 Topics: Acute Kidney Injury; Adenine; Amphotericin B; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Calcineurin Inhibitors; Cidofovir; Cyclooxygenase Inhibitors; Cytosine; Foscarnet; Hemodynamics; Humans; Hydroxyethyl Starch Derivatives; Immunoglobulins, Intravenous; Intensive Care Units; Kidney; Organophosphonates; Tacrolimus	2004
[Advances in the study of nucleoside antiviral drugs]. Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:8 Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cidofovir; Cytosine; Dioxolanes; Humans; Molecular Structure; Nucleosides; Organophosphonates; Purine Nucleosides; Tenofovir	2006
The discovery of antiviral agents: ten different compounds, ten different stories. Medicinal research reviews, 2008, Volume: 28, Issue:6 Topics: Acyclovir; Adenine; Antiviral Agents; Benzodiazepines; Benzylamines; Cidofovir; Cyclams; Cytosine; Heterocyclic Compounds; Humans; Imidazoles; Nucleosides; Organophosphonates; Tenofovir; Valacyclovir; Valine; Virus Diseases	2008
Progress in the discovery of compounds inhibiting orthopoxviruses in animal models. Antiviral chemistry & chemotherapy, 2008, Volume: 19, Issue:3 Topics: Adenine; Animals; Antiviral Agents; Benzamides; Cidofovir; Cytosine; Disease Models, Animal; Drug Discovery; Humans; Isoindoles; Organophosphonates; Orthopoxvirus; Prodrugs	2008
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond. Biochemical pharmacology, 2011, Jul-15, Volume: 82, Issue:2 Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Guanosine; Hepatitis B; HIV Infections; Humans; Organophosphonates; Prodrugs; Structure-Activity Relationship; Tenofovir	2011
Application of kinase bypass strategies to nucleoside antivirals. Antiviral research, 2011, Volume: 92, Issue:2 Topics: Adenine; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytosine; History, 20th Century; History, 21st Century; Humans; Nucleosides; Nucleotides; Organophosphonates; Phosphotransferases; Tenofovir	2011
The Holý Trinity: the acyclic nucleoside phosphonates. Advances in pharmacology (San Diego, Calif.), 2013, Volume: 67 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Humans; Nucleosides; Organophosphonates; Prodrugs; Tenofovir; Virus Diseases	2013
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals. Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:10 Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; Humans; Nucleosides; Nucleotides; Organophosphonates; Prodrugs	2017

Other Studies

58 other study(ies) available for adenine and cidofovir anhydrous

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents. Journal of virological methods, 1992, Volume: 38, Issue:2 Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Deoxyuracil Nucleotides; Drug Evaluation; Flow Cytometry; Herpesvirus 3, Human; Humans; Organophosphonates; Organophosphorus Compounds; Thymidine Kinase; Viral Envelope Proteins; Virus Replication	1992
Comparative activity of various compounds against clinical strains of herpes simplex virus. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1992, Volume: 11, Issue:2 Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytopathogenic Effect, Viral; Cytosine; Dextran Sulfate; Guanine; HeLa Cells; Heparin; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Virus Replication	1992
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytomegalovirus; Cytosine; Flow Cytometry; Ganciclovir; Humans; Microbial Sensitivity Tests; Nucleic Acid Hybridization; Organophosphonates; Organophosphorus Compounds; Viral Plaque Assay	1991
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; Herpes Simplex; Immune Tolerance; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Opportunistic Infections; Organophosphonates; Organophosphorus Compounds	1991
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Hempa; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Thymidine Kinase	1991
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. Antiviral research, 1990, Volume: 13, Issue:6 Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin	1990
Inhibitory effect of (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP on clinical ocular adenoviral isolates is serotype-dependent in vitro. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Adenovirus Infections, Human; Adenoviruses, Human; Antiviral Agents; Cidofovir; Conjunctivitis, Viral; Cytosine; DNA; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Serotyping; Tumor Cells, Cultured; Viral Plaque Assay	1991
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro. The Journal of infectious diseases, 1991, Volume: 163, Issue:2 Topics: Adenine; Adenosine; Antiviral Agents; Cell Line; Cidofovir; Cytidine; Cytomegalovirus; Cytosine; Ganciclovir; Guanosine; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds; Thymidine	1991
Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine. Journal of medicinal chemistry, 1990, Volume: 33, Issue:6 Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Guanine; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Viral Plaque Assay	1990
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1990, Volume: 9, Issue:8 Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Foscarnet; Ganciclovir; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Zidovudine	1990
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates. Molecular pharmacology, 1995, Volume: 47, Issue:4 Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Foscarnet; Organophosphonates; Organophosphorus Compounds; Vero Cells	1995
Antitrypanosomal activity of phosphonylmethoxyalkylpurines. The Journal of parasitology, 1994, Volume: 80, Issue:6 Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African	1994
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1994, Volume: 56, Issue:6 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; DNA, Viral; Ganciclovir; Herpesviridae Infections; Humans; Immunologic Deficiency Syndromes; Mice; Mice, SCID; Muromegalovirus; Organophosphonates; Organophosphorus Compounds; Virus Replication	1994
Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA). Folia biologica, 1993, Volume: 39, Issue:3 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Chick Embryo; Cidofovir; Cytosine; Female; Fibroblasts; Humans; Lung; Male; Mitosis; Organophosphonates; Organophosphorus Compounds; Polydactyly; Rats; Rats, Inbred BN; Rats, Inbred Lew	1993
Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1. Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11 Topics: Abortion, Spontaneous; Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Female; Herpesviridae Infections; Herpesvirus 1, Equid; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Pregnancy; Virus Replication	1993
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochemical pharmacology, 1994, Jan-13, Volume: 47, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Nucleus; Cidofovir; Cytosine; Herpesviridae; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Structure-Activity Relationship; Thymidine Kinase; Virus Replication	1994
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs. European journal of pharmacology, 1995, Nov-24, Volume: 286, Issue:3 Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred BN; Rats, Inbred Lew	1995
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6. Antiviral research, 1995, Volume: 28, Issue:4 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytopathogenic Effect, Viral; Cytosine; Flow Cytometry; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds	1995
Application of a gastric cancer cell line (MKN-28) for anti-adenovirus screening using the MTT method. Antiviral research, 1996, Volume: 31, Issue:3 Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cidofovir; Cytosine; Drug Evaluation, Preclinical; Formazans; Ganciclovir; Humans; Idoxuridine; Organophosphonates; Organophosphorus Compounds; Purines; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	1996
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:7 Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Drug Resistance, Microbial; Fibroblasts; Foscarnet; Humans; Lung; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid	1996
An ocular model of Adenovirus type 5 infection in the rabbit. Bulletin de la Societe belge d'ophtalmologie, 1995, Volume: 259 Topics: Adenine; Adenoviridae; Adenoviridae Infections; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; Eye Diseases; Organophosphonates; Organophosphorus Compounds; Rabbits; Virus Replication	1995
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes. Antiviral research, 1997, Volume: 35, Issue:1 Topics: Adenine; Anti-HIV Agents; Antiviral Agents; CD4 Antigens; Cell Line; Cidofovir; Cytosine; Genetic Engineering; HeLa Cells; Herpesvirus 1, Human; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Phosphorylation; T-Lymphocytes; Virus Replication	1997
Antiviral drug susceptibility of human herpesvirus 8. Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:12 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA Replication; DNA, Viral; Herpesvirus 8, Human; Humans; Organophosphonates; Organophosphorus Compounds	1997
Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates. International journal of antimicrobial agents, 1999, Volume: 12, Issue:1 Topics: Adenine; Animals; Antimalarials; Cidofovir; Cytosine; Erythrocytes; Ganciclovir; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Plasmodium falciparum; Structure-Activity Relationship	1999
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Molecular pharmacology, 1999, Volume: 56, Issue:3 Topics: Adenine; Amino Acid Sequence; Animals; Anion Transport Proteins; Antiviral Agents; Base Sequence; Biological Transport; Carrier Proteins; Cidofovir; Cloning, Molecular; Cytosine; DNA, Complementary; Humans; Immunoblotting; Kidney; Molecular Sequence Data; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats	1999
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:3 Topics: Adenine; Alanine; Animals; Anion Transport Proteins; Antiviral Agents; Biological Transport; Carrier Proteins; CHO Cells; Cidofovir; Cricetinae; Cytosine; Humans; Kidney; Organophosphate Poisoning; Organophosphonates; Organophosphorus Compounds; Probenecid	2000
A rocky road for nucleotide analogs. GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies, 1998, Volume: 12, Issue:9 Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytomegalovirus Retinitis; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds	1998
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Kidney Tubules, Proximal; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Agents; Xenobiotics	2001
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs. Cancer research, 2001, Nov-01, Volume: 61, Issue:21 Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Division; Cidofovir; Cytosine; Epithelial Cells; Growth Inhibitors; Herpesvirus 4, Human; Humans; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Xenograft Model Antitumor Assays	2001
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:7 Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Poxviridae Infections; Prodrugs; Skin; Tenofovir; Virus Replication	2003
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? Antiviral research, 2004, Volume: 61, Issue:3 Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins	2004
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro. The Journal of infectious diseases, 2005, Feb-01, Volume: 191, Issue:3 Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Esters; Ether; Humans; Lipids; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Prodrugs; Virus Replication	2005
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2 Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA; Genetic Variation; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transport Protein 1; Organophosphonates; p-Aminohippuric Acid; Polymorphism, Single Nucleotide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Complementary; Tenofovir; Xenopus laevis	2005
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. The Journal of general virology, 2005, Volume: 86, Issue:Pt 8 Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Ganciclovir; Guanine; Humans; Mice; Models, Molecular; Molecular Sequence Data; Muromegalovirus; Mutation; Organophosphonates; Protein Kinases; Sequence Alignment; Valacyclovir; Valine; Virus Replication	2005
Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:12 Topics: Adenine; Animals; Cell Line; Cell Line, Transformed; Cidofovir; Cytosine; Humans; Keratinocytes; Nucleosides; Orf virus; Organophosphonates; Organophosphorus Compounds; Sheep	2005
Inhibition of the replication of DNA viruses by phosphonylmethoxyalkyl-purines and -pyrimidines. Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA Viruses; Organophosphonates; Simplexvirus; Virus Replication	1989
Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:7 Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cyclization; Cytopathogenic Effect, Viral; Cytosine; Esters; Fibroblasts; Humans; Keratinocytes; Organophosphonates; Orthopoxvirus	2006
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. Biochemical pharmacology, 2007, Apr-01, Volume: 73, Issue:7 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses	2007
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA. Antiviral research, 2007, Volume: 75, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Ecthyma, Contagious; Fibroblasts; Humans; In Vitro Techniques; Keratinocytes; Lung; Nucleosides; Orf virus; Organophosphonates; Prodrugs; Sensitivity and Specificity; Sheep	2007
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. Veterinary microbiology, 2007, May-16, Volume: 122, Issue:1-2 Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Epithelial Cells; Foscarnet; Ganciclovir; Herpesvirus 1, Equid; Horses; Lung; Organophosphonates	2007
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. Antiviral research, 2007, Volume: 75, Issue:1 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cowpox; Cytomegalovirus Infections; Cytosine; Herpes Simplex; HIV-1; Humans; In Vitro Techniques; Molecular Structure; Organophosphonates; Sensitivity and Specificity; Vaccinia	2007
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharmaceutical research, 2007, Volume: 24, Issue:4 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Humans; Kidney; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Probenecid; Tenofovir; Transfection	2007
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. Antiviral therapy, 2007, Volume: 12, Issue:5 Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Disease Models, Animal; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Exodeoxyribonucleases; Foscarnet; Genotype; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Models, Molecular; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Phenotype; Protein Binding; Protein Conformation; Vero Cells; Viral Proteins; Virulence	2007
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Male; Mice; Microscopy, Electron, Transmission; Nucleosides; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Swiss 3T3 Cells; Virus Replication	2007
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA Primers; DNA-Directed DNA Polymerase; DNA, Viral; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Templates, Genetic; Vaccinia virus; Virus Replication	2008
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models. Antiviral research, 2008, Volume: 79, Issue:2 Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Herpesviridae Infections; Liver; Mice; Mice, Inbred BALB C; Mice, SCID; Muromegalovirus; Organophosphonates; Survival Analysis	2008
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues. Antiviral therapy, 2008, Volume: 13, Issue:1 Topics: Adenine; Anti-HIV Agents; Binding Sites; Cidofovir; Cytosine; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Organophosphonates; Protein Conformation; Tenofovir	2008
Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs. Current protocols in nucleic acid chemistry, 2007, Volume: Chapter 15 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Magnetic Resonance Spectroscopy; Organophosphonates; Spectrometry, Mass, Electrospray Ionization	2007
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir	2009
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain. Bioorganic & medicinal chemistry, 2009, Jun-01, Volume: 17, Issue:11 Topics: Acids, Acyclic; Adenine; Antiviral Agents; Aza Compounds; Cidofovir; Cytosine; DNA Viruses; HeLa Cells; Humans; Molecular Structure; Nucleosides; Organophosphonates; RNA Viruses; Tenofovir	2009
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector. Electrophoresis, 2009, Volume: 30, Issue:12 Topics: Adenine; Anti-HIV Agents; beta-Cyclodextrins; Cidofovir; Cytosine; Electrolytes; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Linear Models; Organophosphonates; Purines; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tenofovir	2009
Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine. Bioorganic & medicinal chemistry, 2011, May-01, Volume: 19, Issue:9 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cowpox virus; Cytosine; Ectromelia virus; Esters; Guinea Pigs; Haplorhini; Humans; Liver; Organophosphonates; Rats; Vaccinia virus	2011
New prodrugs of Adefovir and Cidofovir. Bioorganic & medicinal chemistry, 2011, Jun-01, Volume: 19, Issue:11 Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus	2011
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies. Journal of medicinal chemistry, 2011, Aug-25, Volume: 54, Issue:16 Topics: Adenine; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cidofovir; Cowpox virus; Cytomegalovirus; Cytosine; Fibroblasts; Herpesvirus 1, Human; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Structure; Organophosphonates; Prodrugs; Rats; Tyrosine; Vaccinia virus	2011
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:1 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Organic Anion Transport Protein 1; Organophosphonates; Tenofovir; Toxicity Tests	2015
A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. The AAPS journal, 2016, Volume: 18, Issue:2 Topics: 3T3 Cells; Adenine; Animals; Antiviral Agents; Cell Line; Cell Line, Transformed; Cell Survival; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Forecasting; Gene Expression Regulation; HEK293 Cells; Humans; Kidney Tubules, Proximal; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates	2016
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein. Molecular pharmaceutics, 2017, 08-07, Volume: 14, Issue:8 Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir	2017