adenine and alanosine

adenine has been researched along with alanosine in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19909 (75.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Graff, JC; Plagemann, PG1
Dye, FJ; Kollar, EJ1
Bingham, H; Chan, VL; Du, RP; Juranka, P; Pang, JC1
Allan, PW; Bennett, LL; Brockman, RW; Rose, LM; Shaddix, SC1
Martin, GM; Turker, MS1
Assandri, A; Barone, D; Galliani, G; Grandi, M; Lancini, GC; Mistrello, G1
El Sayed, YM; Nguyen, BT; Sadée, W1
Cadman, E; Goldberg, D; Heimer, R1
Gupta, RS1
Batova, A; Carrera, CJ; Cottam, H; Diccianni, MB; Yu, AL; Yu, J1
Burris, HA; Kindler, HL; Oliff, IA; Sandler, AB1

Trials

1 trial(s) available for adenine and alanosine

ArticleYear
A phase II multicenter study of L-alanosine, a potent inhibitor of adenine biosynthesis, in patients with MTAP-deficient cancer.
    Investigational new drugs, 2009, Volume: 27, Issue:1

    Topics: Adenine; Adolescent; Adult; Aged; Alanine; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Humans; Male; Neoplasms; Purine-Nucleoside Phosphorylase

2009

Other Studies

11 other study(ies) available for adenine and alanosine

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Alanosine toxicity in Novikoff rat hepatoma cells due to inhibition of the conversion of inosine monophosphate to adenosine monophosphate.
    Cancer research, 1976, Volume: 36, Issue:4

    Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Alanine; Aspartic Acid; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cells, Cultured; Depression, Chemical; DNA, Neoplasm; Glucose; Hypoxanthines; Inosine Nucleotides; Liver Neoplasms; Mengovirus; Neoplasm Proteins; Neoplasms, Experimental; Nitroso Compounds; Purine Nucleotides; Pyrimidine Nucleotides; RNA, Neoplasm; Succinates; Uracil Nucleotides; Uridine

1976
Inhibition of mouse molar tooth germ morphogenesis in organ culture by alanosine.
    Experimental cell biology, 1978, Volume: 46, Issue:3

    Topics: Adenine; Alanine; Animals; Mice; Mice, Inbred BALB C; Mitosis; Molar; Morphogenesis; Nitrosamines; Odontogenesis; Organ Culture Techniques; Tooth Germ

1978
Imbalance of purine nucleotides in alanosine-resistant baby hamster kidney cells.
    Somatic cell and molecular genetics, 1989, Volume: 15, Issue:2

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Adenylosuccinate Lyase; Adenylosuccinate Synthase; Alanine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Culture Media; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphotransferases; Purines; Selection, Genetic; Transformation, Genetic; Uridine

1989
Alterations in nucleotide pools induced by 3-deazaadenosine and related compounds. Role of adenylate deaminase.
    Biochemical pharmacology, 1988, Apr-01, Volume: 37, Issue:7

    Topics: Adenine; Adenosine Kinase; Alanine; Aminoglycosides; AMP Deaminase; Animals; Anti-Bacterial Agents; Cell Survival; Coformycin; Hypoxanthine; Hypoxanthines; Mice; Nucleotide Deaminases; Nucleotides; Time Factors; Tubercidin

1988
Induction of adenine salvage in mouse cell lines deficient in adenine phosphoribosyltransferase.
    Molecular and cellular biology, 1985, Volume: 5, Issue:10

    Topics: 2-Aminopurine; Adenine; Adenine Phosphoribosyltransferase; Alanine; Animals; Azaserine; Cell Line; Cross Reactions; Drug Resistance; Gene Expression Regulation; Karyotyping; Mice; Mycoplasma; Pentosyltransferases

1985
Contragestational profile of the tumor-inhibiting agent, L-alanosine, in the rat and the hamster.
    Cancer chemotherapy and pharmacology, 1985, Volume: 14, Issue:1

    Topics: Adenine; Alanine; Animals; Antibiotics, Antineoplastic; Aspartic Acid; Cell Division; Cricetinae; Dose-Response Relationship, Drug; Female; Fertility; Mesocricetus; Pregnancy; Rats; Rats, Inbred Strains; Time Factors

1985
Interaction among the distinct effects of adenine and guanine depletion in mouse lymphoma cells.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Adenine; Adenosine; Alanine; Animals; Antimetabolites, Antineoplastic; Cell Division; DNA Replication; Guanine; Kinetics; Lymphoma; Methylthioinosine; Mice; Mycophenolic Acid

1984
Modulation of fluoropyrimidine metabolism in L1210 cells by L-alanosine.
    Biochemical pharmacology, 1983, Jan-15, Volume: 32, Issue:2

    Topics: Adenine; Alanine; Animals; Aspartic Acid; Cells, Cultured; Clone Cells; Deoxyuridine; Leukemia L1210; Mice; Nucleotides; Pyrimidines; Time Factors

1983
A novel synergistic effect of alanosine and guanine on adenine nucleotide synthesis in mammalian cells. Alanosine as a useful probe for investigating purine nucleotide metabolism.
    Journal of cellular physiology, 1980, Volume: 104, Issue:2

    Topics: Adenine; Adenine Nucleotides; Adenylosuccinate Synthase; Alanine; Animals; Cell Division; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Drug Synergism; Female; Guanine; Humans; Nitrosamines; Ovary; Purine Nucleotides

1980
EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine.
    Blood, 2006, Feb-01, Volume: 107, Issue:3

    Topics: Adenine; Alanine; Antibiotics, Antineoplastic; Cell Line, Tumor; Deoxyadenosines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Erythroid Precursor Cells; Furans; Granulocyte Precursor Cells; Humans; Leukemia-Lymphoma, Adult T-Cell; Purine-Nucleoside Phosphorylase; Salvage Therapy; Thionucleosides

2006