adenine has been researched along with adefovir in 944 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (0.74) | 18.7374 |
| 1990's | 127 (13.45) | 18.2507 |
| 2000's | 360 (38.14) | 29.6817 |
| 2010's | 434 (45.97) | 24.3611 |
| 2020's | 16 (1.69) | 2.80 |
| Authors | Studies |
|---|---|
| Balzarini, J; Bergamini, A; Calio, R; De Clercq, E; Milanese, G; Pauwels, R; Perno, CF; Rocchi, G; Yarchoan, R | 1 |
| Cerny, J; Cheng, YC; Foster, SA | 2 |
| Hitchcock, MJ; Mansuri, MM; Martin, JC; Starrett, JE; Tortolani, DR | 1 |
| Ebner, JP; Hoover, EA; Philpott, MS | 1 |
| Beer, B; Donath, A; Egberink, HF; Hartmann, K; Hoffmann-Fezer, G; Horzinek, MC; Lutz, H; Thefeld, S; Thum, I | 1 |
| Cronn, RC; North, TW; Preston, BD; Remington, KM | 1 |
| Cihlár, T; Herve, TY; Holý, A; Jindrich, J; Merta, A; Otmar, M; Rosenberg, I; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Naesens, L | 4 |
| De Clercq, E; Maudgal, PC | 2 |
| De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE | 1 |
| Ebner, JP; Hoover, EA; Mullins, JI; Zeidner, NS | 1 |
| Egberink, HF; Hartman, K; Horzinek, MC | 1 |
| Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Hao, Z; Herdewijn, P; Johns, DG | 1 |
| Broder, S; Kageyama, S; Mitsuya, H; Yarchoan, R | 1 |
| Balestra, E; Balzarini, J; Calio, R; De Clercq, E; Del Gobbo, V; Foli, A; Marini, S; Perno, CF; Villani, N | 1 |
| Balzarini, J; De Clercq, E; Palú, G; Parolin, C; Rassu, M; Stefanelli, S | 1 |
| Klunk, LJ; Marrero, D; Russell, JW; Starrett, JE; Whiterock, VJ | 1 |
| De Clercq, E | 7 |
| Balzarini, J; De Clercq, E | 1 |
| Balzarini, J; Bronson, R; De Clercq, E; Jaenisch, R; Lee, JS; Mullaney, S; Ruprecht, RM; Sharpe, AH | 1 |
| Balzarini, J; De Clercq, E; Holý, A; Naesens, L; Niphuis, H; Rosenberg, I; Schellekens, H; Slachmuylders, J | 1 |
| Bronson, JJ; De Boeck, H; Ghazzouli, I; Hitchcock, MJ; Ho, HT; Martin, JC; Woods, K | 1 |
| De Clercq, E; Konno, K; Mochizuki, S; Mori, S; Shigeta, S; Yokota, T | 1 |
| Balzarini, J; De Clercq, E; Gangemi, JD; Ghaffar, A; Mayer, E; Mayer, R; Midoux, P; Monsigny, M; Negre, E; Roche, AC | 1 |
| Balzarini, J; Borst, M; De Clercq, E; Egberink, H; Horzinek, M; Koolen, M; Neu, H; Niphuis, H; Schellekens, H | 1 |
| Holý, A; Merta, A; Rosenberg, I; Veselý, J; Votruba, I | 2 |
| Awan, AR; Field, HJ | 1 |
| Bernaerts, R; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Votruba, I | 1 |
| Cerný, J; Holý, A; Otmar, M; Rosenberg, I; Vonka, V; Votruba, I | 1 |
| Anisimová, E; Cerný, J; Holý, A; Rosenberg, I; Vonka, V; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Naesens, L; Sobis, H; Vandeputte, M | 1 |
| Brian, EL; De Clercq, E; Pagano, JS; Smith, MS | 1 |
| Balzarini, J; Cozens, RM; De Clercq, E; Gangemi, JD; Hochkeppel, HK | 1 |
| De Clercq, E; Holý, A; Rosenberg, I | 1 |
| DeClercq, E; Lin, JC; Pagano, JS | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Holy, A; Johns, DG; Naesens, L; Pauwels, R; Rosenberg, I | 1 |
| De Clercq, E; Gil-Fernández, C | 1 |
| Chen, MS; Cherrington, JM; Foli, A; Gu, Z; Mulato, AS; Salomon, H; Sogocio, KM; Wainberg, MA; Yarchoan, R | 1 |
| Balestra, E; Balzarini, J; Caliò, R; De Clercq, E; Del Gobbo, V; Holy, A; Perno, CF; Sesa, F; Villani, N | 1 |
| Gelbic, I; Marec, F | 1 |
| Bischofberger, N; Follis, KE; Grant, R; Sabo, A; Tsai, CC | 1 |
| Balzarini, J | 1 |
| Cihlár, T; Holý, A; Rosenberg, I; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Goebels, J; Hatse, S; Sobis, H; Vandeputte, M; Verstuyf, A | 1 |
| Aduma, P; Connelly, MC; Fridland, A; Srinivas, RV | 1 |
| Balzarini, J; De Clercq, E; Georgsson, G; Naesens, L; Pálsson, PA; Thormar, H; Torsteinsdóttir, S | 1 |
| Ashton, RJ; Bailey, S; Harnden, MR; Jackson, SM; Serafinowska, HT; Sutton, D | 1 |
| De Clercq, E; Kaminsky, R; Zweygarth, E | 1 |
| Balestra, E; Balzarini, J; Caliò, R; De Clercq, E; Del Gobbo, V; Fabrizi, E; Perno, CF; Villani, N | 1 |
| Franková, D; Holý, A; Otová, B; Votruba, I; Zídek, Z | 1 |
| Connelly, MC; Fridland, A; Marshall, DR; Robbins, BL; Srinivas, RV | 1 |
| Holý, A; Kren, V; Krenová, D; Otová, B; Votruba, I; Zídek, Z | 1 |
| Cundy, KC; Fishback, JA; Lee, ML; Lee, WA; Shaw, JP; Soike, KF; Visor, GC | 1 |
| Fridland, A; Gong, YF; Marshall, DR; Srinivas, RV | 1 |
| Hitchcock, MJ; Mansuri, MM; Martin, JC; Russell, J; Starrett, JE; Tortolani, DR; Whiterock, V | 1 |
| Bartz, C; Benveniste, RE; Bischofberger, N; Follis, KE; Grant, RF; Nolte, RE; Sabo, A; Tsai, CC | 1 |
| Holý, A; Kren, V; Otová, B; Sladká, M; Votruba, I | 1 |
| Blazek, K; Holý, A; Otová, B; Schramlová, J; Sladká, M; Votruba, I | 1 |
| Bílá, V; Holý, A; Jelínek, R; Kren, V; Mejsnarová, B; Otová, B; Sladká, M | 1 |
| Cundy, KC; Lee, WA; Shaw, JP | 1 |
| Elleder, D; Elleder, M; Kren, V; Otová, B; Panczak, A; Sladká, M | 1 |
| Bischofberger, N; Connelly, MC; Fridland, A; Gong, YF; Robbins, BL; Srinivas, RV | 1 |
| Elleder, D; Elleder, M; Holý, A; Kren, V; Otová, B; Panczak, A | 1 |
| Aubertin, AM; Gosselin, G; Imbach, JL; Kirn, A; Lefebvre, I; Pompon, A; Puech, F | 1 |
| Holý, A; Merta, A; Stĕtina, R; Votruba, I | 1 |
| De Clercq, E; Neyts, J | 1 |
| Balzarini, J; Berk, L; De Clercq, E; De Wilde, GA; Heijtink, RA; Holy, A; Kruining, J; Schalm, SW | 1 |
| Barditch-Crovo, P; Collier, AC; Cundy, KC; Ebeling, D; Jaffe, HS; Toole, J; Walker, RE | 1 |
| Aquaro, S; Balzarini, J; De Clercq, E; Holý, A; Perno, CF; Witvrouw, M | 1 |
| Franková, D; Holý, A; Otová, B; Zídek, A | 1 |
| Connelly, MC; Fridland, A; Greenhaw, J; Robbins, BL | 1 |
| Aquaro, S; Balestra, E; Balzarini, J; Calio, R; Cenci, A; Di Pierro, D; Lazzarino, G; Panti, S; Perno, CF; Tavazzi, B | 1 |
| Ahmed, PS; Brennan, TM; Bridges, CG; Casara, P; Hornsperger, JM; Navé, JF; Taylor, DL; Tyms, AS | 1 |
| Allen, SJ; Chen, MS; Cherrington, JM; Fuller, MD; Kunder, SC; Lesnikowski, Z; Mulato, AS; Schinazi, RF; Sommadossi, JP; Ussery, MA | 1 |
| Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L | 1 |
| Arends, S; Kamp, W; Schokker, J; van Halteren, E | 1 |
| Konno, K; Shigeta, S; Sudo, K; Yokota, T | 1 |
| Chen, MS; Cherrington, JM; Fuller, MD; Mulato, AS | 1 |
| Anderson, B; Cherrington, JM; Foli, A; Gu, Z; Kavlick, M; Mitsuya, H; Saville, MW; Sogocio, KM; Wainberg, MA; Yarchoan, R | 1 |
| Balzarini, J; De Clercq, E; Hatse, S | 3 |
| Aubertin, AM; Benzaria, S; Gosselin, G; Imbach, JL; Johnson, R; Maury, G; Obert, G; Pélicano, H | 1 |
| Aquaro, S; Balestra, E; Balzarini, J; Caliò, R; Cenci, A; Di Pierro, D; Garaci, E; Grimaldi, S; Lazzarino, G; Perno, CF; Santoro, N; Tavazzi, B | 1 |
| Balzarini, J; Casara, P; De Clercq, E; Egberink, H; Hartmann, K; Navé, JF; Pannecouque, C; Vahlenkamp, T; Witvrouw, M | 1 |
| Casara, P; Foresman, L; Joag, SV; Li, Z; Narayan, O; Navé, JF; Pinson, DM; Raghavan, R; Stephens, EB | 1 |
| Annaert, P; Augustijns, P; de Clercq, E; Kinget, R; Naesens, L | 1 |
| Arimilli, MN; Bidgood, AM; Cundy, KC; Jones, RJ; Krishnamurthy, VV; Lee, WA; Louie, MS; Shaw, JP | 1 |
| Connelly, MC; Fridland, A; Lee, SH; Pisarev, VM | 1 |
| Connely, M; Fridland, A; Srinivas, RV | 1 |
| Bischofberger, N; Fauci, AS; Hirsch, VM; Kinter, A; Lifson, JD; Lloyd, AL; Nowak, MA; Vasquez, GM; Wahl, LM; Williams, J; Wiltrout, TA | 1 |
| Cherrington, JM; Mulato, AS | 1 |
| Chen, MS; Cherrington, JM; Flores, C; Fuller, MD; Mendel, DB; Moon, K; Mulato, AS; Xiong, X | 1 |
| Balzarini, J; Erfle, V; Goebel, F; Goldberg, M; Hartmann, K; Kuffer, M; Rolinski, B | 1 |
| Balzarini, J; Bischofberger, N; De Clercq, E; Erfle, V; Goebel, FD; Goldberg, M; Hartmann, K; Holy, A; Jindrich, J; Kraft, W; Kuffer, M; Naesens, L | 1 |
| Annaert, P; Augustijns, P; Benzaria, S; de Clercq, E; Gosselin, G; Hatse, S; Imbach, JL; Kinget, R; Naesens, L; Pompon, A; Valette, G; Van den Mooter, G | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 2 |
| Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Segers, C; Vandeputte, M; Waer, M | 1 |
| Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Vandeputte, M; Waer, M | 1 |
| Baba, M; De Clercq, E; Makino, M; Okada, Y; Suruga, Y; Tanaka, H | 1 |
| Flores, C; Gibbs, CS; Toole, JJ; Xiong, X; Yang, H | 1 |
| Angus, PW; Colledge, DL; Locarnini, SA; Nicoll, AJ; Smallwood, RA; Toole, JJ | 1 |
| Havel, J; Holý, A; Revilla, A; Vargas, G | 1 |
| Balzarini, J; De Clercq, E; Georgsson, G; Gunnarsson, E; Naesens, L; Thormar, H; Torsteinsdóttir, S | 1 |
| Cundy, KC | 1 |
| Cheng, YC; Fu, L; Liu, SH | 1 |
| Carrilho, FJ; Kato, N; Lan, KH; Omata, M; Ono-Nita, SK; Shiratori, Y; Yoshida, H | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Schols, D | 1 |
| Birkus, G; Holý, A; Otová, B; Votruba, I | 1 |
| Merigan, TC; Palmer, S; Shafer, RW | 1 |
| Franková, D; Holý, A; Zídek, Z | 1 |
| Cihlar, T; Fuller, MD; Lin, DC; Mendel, DB; Pritchard, JB; Sweet, DH | 1 |
| Biessen, EA; Bijsterbosch, MK; de Vrueh, RL; Rump, ET; Sliedregt, LA; van Berkel, TJ | 1 |
| Connelly, MC; Flynn, PM; Fridland, A; Kumar, A; Paibir, SG; Schuetz, JD; Srinivas, RV; Sun, D | 1 |
| Collier, AC; Schwartz, MA | 1 |
| Downey, KM; Kramata, P | 1 |
| Gosselin, G; Johnson, RA; Laux, WH; Périgaud, C; Shoshani, I | 1 |
| Beijnen, JH; Hoetelmans, RM; Sparidans, RW; Veldkamp, A | 1 |
| Balzarini, J; Biessen, EA; Bijsterbosch, MK; de Vrueh, RL; Rump, ET; van Berkel, TJ; van De Bilt, E; van Veghel, R | 1 |
| Civitico, G; Colledge, D; Locarnini, S; Shaw, T | 1 |
| Boucher, CA; Cambridge, E; De Groot, T; De Jong, S; Kamp, W; Schokker, J; Schuurman, R | 1 |
| Erhardt, A; Häussinger, D; Heintges, T; Petry, W | 1 |
| Cihlar, T; Ho, ES; Lin, DC; Mendel, DB | 1 |
| De Clercq, E; Neyts, J; Ying, C | 1 |
| De Clercq, E; Furman, P; Neyts, J; Nicholson, W; Ying, C | 1 |
| Freiman, JS; McCaughan, GW | 1 |
| Bischofberger, N; Crabbs, C; Greenhouse, J; Jiang, JB; Lewis, MG; Racz, K; Racz, P; Silvera, P; Yalley-Ogunro, J | 1 |
| Burda, MR; Dandri, M; Petersen, J; Will, H | 1 |
| Warner, D | 1 |
| Abrahams, PJ; Biessen, EA; Bijsterbosch, MK; De Vrueh, RL; Prince, P; Sliedregt, LA; Valentijn, AR; Van Berkel, TJ; Van Boom, JH; Van De Bilt, E; Van Der Marel, GA | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Acosta, E; Cheng, H; Fischl, M; Fiscus, SA; Fletcher, CV; Freimuth, W; Gulick, RM; Haubrich, R; Hu, XJ; Katzenstein, D; Lagakos, SW; Mills, C; Pettinelli, C; Snyder, S; Swanstrom, R | 1 |
| Folkers, G; Pautsch, A; Perozzo, R; Pilger, B; Prota, A; Scapozza, L; Schelling, P; Schulz, GE; Vogt, J | 1 |
| Beck, TW; Bischofberger, N; Emau, P; Follis, KE; Morton, WR; Sun, JC; Tran, CA; Tsai, CC | 1 |
| Acosta, EP; Cheng, H; Fischl, M; Fletcher, CV; Gulick, RM; Haubrich, R; Hu, XJ; Katzenstein, D; Mills, C; Raasch, R; Remmel, RP | 1 |
| Hatse, S | 1 |
| Regev, A; Schiff, ER | 1 |
| Aguesse-Germon, S; Jamard, C; Pichoud, C; Seignères, B; Trépo, C; Vuillermoz, I; Zoulim, F | 1 |
| Grande Santamaría, L; Romero Gómez, M; Suárez García, E | 1 |
| Arnold, E; Das, K; Gibbs, CS; Sarafianos, SG; Westland, CE; Xiong, X; Yang, H | 1 |
| Ballatore, C; Balzarini, J; De Clercq, E; McGuigan, C | 1 |
| Smart, T | 1 |
| Cheng, B | 1 |
| Balestra, E; Brandi, G; Cappellacci, L; Franchetti, P; Grifantini, M; Magnani, M; Perno, CF; Rossi, L; Schiavano, GF; Serafini, S | 1 |
| Holý, A; Kampf, G; Kapinos, LE; Lippert, B; Lüth, MS; Müller, J; Sigel, H | 1 |
| Delaney, WE; Locarnini, S; Shaw, T | 1 |
| Werle, B; Zoulim, F | 1 |
| Bell, A; D'agati, VD; Kambham, N; Markowitz, GS; Tanji, K; Tanji, N | 1 |
| Bock, T; Chin, R; Furman, P; Isom, H; Locarnini, S; Manns, M; Shaw, T; Sozzi, V; Torresi, J; Trautwein, C | 1 |
| Biessen, EA; Bijsterbosch, MK; de Clercq, E; de Vrueh, RL; Neyts, J; van Berkel, TJ; Ying, C | 1 |
| Anton, KE; Cherrington, JM; Fuller, MD; Lamy, PD; Margot, NA; Miller, MD; Mulato, AS | 1 |
| Buckheit, R; Gilbert, H; Margot, N; Miller, M; Palmer, S; Shaw, N | 1 |
| Alston, B; Brosgart, CL; Chaloner, K; Cohn, DL; El-Sadr, WM; Fisher, EJ; Grant, LB; Sampson, J; Schmetter, B | 1 |
| Carr, A; Chuah, J; Cooper, DA; Doong, N; French, M; Hoy, J; Hudson, J; Law, M; Mallal, S; Smith, D | 1 |
| Miller, DS | 1 |
| Murono, S; Pagano, JS; Raab-Traub, N | 1 |
| Cane, P; Feraz-Neto, BH; Harrison, R; Mutimer, D; O'Donnell, K; Pillay, D; Shaw, J | 1 |
| de Man, RA; Niesters, HG; Wolters, LM | 1 |
| Delmas, J; Gibbs, C; Hantz, O; Jamard, C; Schorr, O; Trépo, C; Zoulim, F | 1 |
| Bestman-Smith, J; Boivin, G | 1 |
| Boyer, N; Castelneau, C; Marcellin, P | 1 |
| Burda, JV; Dostál, L; Kopecký, V; Mojzes, P | 1 |
| Cappellacci, L; Casabianca, A; Celeste, AG; Cerasi, A; Chiarantini, L; Dominici, S; Franchetti, P; Grifantini, M; Magnani, M; Rossi, L; Serafini, S | 1 |
| Davis, GL | 1 |
| Bowden, S; Chen, RY; Colledge, D; Delaney, WE; Desmond, P; Edwards, R; Isom, H; Locarnini, SA; Shaw, T | 1 |
| Birkus, G; Cihlar, T; Gibbs, CS | 1 |
| Chevallier, M; Cova, L; Gibbs, CS; Guerret, S; Jamard, C; Le Guerhier, F; Thermet, A; Trépo, C; Zoulim, F | 1 |
| Fontana, RJ | 1 |
| Bakshi, KK; Chen, J; Condra, JH; Danovich, RM; DiNubile, MJ; Graham, DJ; Haas, DW; Holder, DJ; Rhodes, RR; Saah, AJ; Shivaprakash, M | 1 |
| Boyer, N; Castelnau, C; Marcellin, P | 1 |
| Iino, S | 2 |
| Belinsky, MG; Chen, ZS; Guo, Y; Hopper-Borge, E; Kotova, E; Kruh, GD; Lee, K | 1 |
| Chen, XY; Yang, HY; Zhang, Y; Zhao, LY; Zhong, DF | 1 |
| Hitchcock, MJ; Holý, A; Keith, KA; Kern, ER; Lee, WA | 1 |
| Bock, CT; Dienes, HP; Klein, C; Kubicka, S; Locarnini, S; Manns, MP; Trautwein, C; Wedemeyer, H; Wüstefeld, T | 1 |
| Jacobson, IM; Purow, DB | 1 |
| De Clercq, E; Frison, E; Helliot, B; Lepoivre, P; Neyts, J; Panis, B; Swennen, R | 1 |
| Maier, KP | 2 |
| Lagget, M; Rizzetto, M | 1 |
| Holý, A; Potmesil, P; Zídek, Z | 1 |
| Fan, ST; Lai, CL; Liu, CL; Lo, CM; Wei, WI; Wong, J; Yong, BH | 1 |
| Crippin, J; Drechsler, H; Lisker-Melman, M; Ristig, M; Tebas, P | 1 |
| Buster, EH; Schalm, SW; van der Eijk, AA | 1 |
| Brosgart, CL; Durantel, D; Durantel, S; Gibbs, CS; Parvaz, P; Trépo, C; Villeneuve, JP; Werle, B; Westland, C; Xiong, S; Zoulim, F | 1 |
| Baumert, TF; Blum, HE; Delaney, WE; Köck, J; von Weizsäcker, F | 1 |
| Delaney, WE; Westland, C; Xiong, S; Yang, H | 1 |
| Camino, N; Núñez, M; Puoti, M; Soriano, V | 1 |
| Bowden, S; Locarnini, S; Shaw, T | 1 |
| Taéron, C | 1 |
| Daftary, MN | 1 |
| Schalm, SW | 1 |
| Hadziyannis, SJ; Papatheodoridis, GV | 2 |
| Mao, YM; Zeng, MD | 1 |
| Bendayan, R; Dallas, S; Schlichter, L | 1 |
| Bergson, P; Gibbs, CS; Shen, Y; Soelaiman, S; Tang, WJ; Wang, CR; Zhukovskaya, NL; Zimmer, MI | 1 |
| Benhamou, Y | 2 |
| Chen, X; Xing, J; Zhong, D | 1 |
| Mauss, S | 2 |
| Sigel, H | 1 |
| Acosta, EP; Brundage, RC; Fletcher, CV; Gulick, RM; Haubrich, R; Jiang, H; Katzenstein, D | 1 |
| Garcia, L; Lin, CC; Liu, Y; Xu, C; Xu, G; Yeh, LT | 1 |
| Boyer, SH; Colby, TJ; Erion, MD; Gomez-Galeno, J; Lemus, RH; Matelich, MC; Reddy, KR; Schanzer, J; Ugarkar, BG; Van Poelje, PD | 1 |
| Andrei, G; De Clercq, E; Snoeck, R | 1 |
| Perelson, AS; Ribeiro, RM | 1 |
| Cooksley, WG | 1 |
| Benhamou, Y; Cahour, A; Katlama, C; Lada, O; Poynard, T; Thibault, V | 1 |
| Chu, CK; Yadav, V | 1 |
| Chen, XS; Ding, GS; Fu, H; Fu, ZR; Guo, WY; Shi, XM; Wang, ZX; Zhang, JJ | 1 |
| Bullough, DA; Colby, TJ; Erion, MD; Fujitaki, JM; Linemeyer, DL; Mackenna, DA; Montag, AC; van Poelje, PD | 1 |
| Sterling, RK; Sulkowski, MS | 1 |
| Ambudkar, SV; Nandigama, K; Sauna, ZE | 1 |
| Delaney, WE; Gibbs, CS; Miller, MD; Xiong, S; Yang, H | 1 |
| Fridland, A; Olson, L; Ray, AS; Vela, JE | 1 |
| Käser, L; Kolyvanos Naumann, U; Vetter, W | 1 |
| Zhou, YH; Zhuang, H | 1 |
| Zhang, DF | 1 |
| Berg, T; Bergk, A; Mauss, S; Reinke, P; Schürmann, D; van Bömmel, F; Wiedenmann, B; Wünsche, T | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Hocková, D; Holý, A; Naesens, L; Pannecouque, C; Snoeck, R | 1 |
| Däumer, M; Kaiser, R; Matz, B; Rockstroh, JK; Schewe, CK; Schildgen, O; Vogel, M; Weitner, L | 1 |
| Ferenci, P | 1 |
| Bain, V; Cooper, C; Lowe, C; Martin, S; Myers, RP; Sherman, M; Villeneuve, JP | 1 |
| Akay, S; Akyildiz, M; Karasu, Z; Tokat, Y | 1 |
| Joannidis, M | 1 |
| Jiang, Y; Xu, Z; Zhang, X | 1 |
| Benhamou, Y; Bonacini, M; Brook, G; Cargnel, A; Puoti, M; Rockstroh, J; Soriano, V; Thio, C | 1 |
| De Clercq, E; Havlas, Z; Hocková, D; Holy, A; Neyts, J; Ying, C | 1 |
| Brett, CM; Brown, C; Burchard, EG; Carlson, EJ; Castro, R; Chen, CW; de la Cruz, M; Ferrin, TE; Fujita, K; Fujita, T; Giacomini, KM; Huang, CC; Johns, SJ; Kawamoto, M; Leabman, MK; Lin, ET; Stryke, D; Taylor, T | 1 |
| Asselah, T; Marcellin, P; Ripault, MP | 1 |
| Dulai, GS; Farid, M; Gralnek, IM; Kanwal, F; Martin, P; Spiegel, BM | 1 |
| Black, M; Owens, DK | 1 |
| von Weizsäcker, F | 1 |
| Bleasby, K; Hall, LA; Mohrenweiser, HW; Perry, JL; Pritchard, JB | 1 |
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| Cane, P; Dudley, T; Freshwater, DA; Mutimer, DJ | 1 |
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| Amini-Bavil-Olyaee, S; Herbers, U; Luedde, T; Mohebbi, SR; Sabahi, F; Tacke, F; Trautwein, C; Zali, MR | 1 |
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| Cai, Q; Chen, J; Chen, K; Duan, H; Geng, Q; Hu, L; Huang, H; Jiang, W; Lin, T; Rao, H; Wu, S; Xia, Z; Yao, M | 1 |
| Cho, YK; Choi, KY; Jeon, WK; Jung, YS; Kim, BI; Kim, HJ; Park, DI; Park, JH; Park, SK; Sohn, CI; Yang, HJ | 1 |
| Arnold, R; Diaz, RS; Duro, RL; Ferreira, MC; Ferreira, PR; Hunter, JR; Komninakis, SV; Leal, É; Mantovani, NP; Santana, LC | 1 |
| Asano, M; Dohi, T; Enomoto, N; Gatanaga, H; Honda, M; Inoue, T; Kaneko, S; Kawamura, YI; Matsumoto, A; Mizokami, M; Murata, K; Nishida, N; Oka, S; Sakamoto, M; Shirasaki, T; Shuno, Y; Sugiyama, M; Tanaka, E; Yano, H | 1 |
| Hu, J; Ji, D; Li, X; Liao, H; Liu, Y; Wu, J; Xin, S; Xu, D; You, S; Zhang, XX; Zhao, J | 1 |
| Chang, KC; Hu, TH; Lin, MT; Tsai, MC; Tseng, PL; Wu, CK; Yen, YH | 1 |
| Li, Z; Liu, Z; Shen, C; Wang, W; Wang, Y; Zhao, C; Zhao, Q | 1 |
| Babudieri, S; Garrucciu, G; Madeddu, G; Maida, I; Melis, M; Mura, MS; Muredda, AA; Ortu, S | 1 |
| An, J; Du, C; Gao, JL; Jiang, Y; Li, M; Ma, H; Wang, X; Zhang, L | 1 |
| Adinolfi, LE; Andreana, L; Boemio, A; Guerrera, B; Marrone, A; Pasquale, G; Rainone, I; Rinaldi, L; Ruggiero, G; Zampino, R | 1 |
| Angarano, G; Fasano, M; Fiore, JR; Leone, A; Maggi, P; Santantonio, TA; Volpe, A | 1 |
| Lim, YS | 1 |
| Cho, EJ; Cho, Y; Chung, GE; Kim, HY; Kim, YJ; Lee, DH; Lee, JH; Lee, M; Yoo, JJ; Yoon, JH; Yu, SJ; Zoulim, F | 1 |
| Krecmerova, M | 1 |
| Chen, FY; Cheng, Z; Huang, HH; Shi, KQ; Van Poucke, S; Zhang, MY; Zheng, JN; Zheng, MH; Zhu, GQ | 1 |
| Capobianchi, MR; D'Offizi, G; Menzo, S; Piselli, P; Solmone, M; Vincenti, D | 1 |
| He, L; Jiang, Y; Liu, X; Wang, X; Yang, Z; Zhang, S; Zhao, Y | 1 |
| Chen, J; Chen, L; Cheng, L; Chi, W; Deng, H; Huo, Y; Lan, Z; Liu, X; Siegenthaler, JA; Song, W; Sun, K; Xu, L; Zhao, X | 1 |
| Liu, CJ; Su, TH | 1 |
| Hu, C; Huang, H; Li, Y; Liu, J; Yang, D; Yuan, G; Zhang, YY; Zhou, F; Zhou, Y | 1 |
| Beuers, U; de Niet, A; Jansen, L; Koot, M; Kuiken, SD; Molenkamp, R; Reesink, HW; Stelma, F; Takkenberg, RB; van Nieuwkerk, CMJ; Verheij, J; Weijer, S; Willemse, SB; Zaaijer, HL | 1 |
| Geng, S; Gong, GZ; Guo, LM; Hu, Z; Huang, L; Li, C; Mi, H; Pan, C; Ren, H; Wang, B; Wang, S; Wang, X; Wang, XY; Wen, YM; Xie, Q; Xu, DZ; Xu, J; Xu, M; Yu, W; Zhang, JM; Zhao, G; Zhou, C; Zhou, X | 1 |
| Kaltashov, IA; Xu, S | 1 |
| Luo, QY; Qiu, ZL; Shen, CT; Sun, ZK; Wei, WJ | 1 |
| Aggeletopoulou, I; Anastassiou, ED; Assimakopoulos, S; Gogos, C; Kalafateli, M; Labropoulou-Karatza, C; Mandellou, M; Taprantzi, D; Thomopoulos, K; Triantos, C; Tselekouni, P; Tsiaoussis, G; Vourli, G | 1 |
| de Jong, MD; Jansen, L; Kootstra, NA; Lopatin, U; Reesink, HW; Takkenberg, RB; van Dort, KA; Welkers, MRA; Zaaijer, HL | 1 |
| Lin, J; Zhang, D; Zhuo, Y | 1 |
| Cha, SK; Cho, DH; Kim, HS; Kim, JH; Kim, WI; Kim, YJ; Lee, EY; Lee, JH; Lee, SM; Park, KS; Park, S | 1 |
| Cui, X; Eichacker, PQ; Fitz, Y; Leppla, S; Li, Y; Moayeri, M; Suffredini, DA; Xu, W | 1 |
| Chen, EQ; Du, LY; Lei, BJ; Lei, XZ; Liao, J; Lu, JJ; Tang, H; Wang, ML; Yan, LB; Zhang, DM; Zhou, TY | 1 |
| Duan, W; Jia, J; Kong, Y; Ma, H; Ou, X; Wang, Q; Wang, X; Wang, Y; Wu, X; You, H; Zhang, W; Zhao, X | 1 |
| Cao, Y; Chen, J; Fu, W; Li, H; Pang, J; Wu, T; Zhou, P | 1 |
| Ahn, SH; Hur, SS; Kang, HS; Kim, DH; Kim, KH; Kwon, SY; Lee, AR; Lee, JH; Park, ES; Park, S; Park, YK; Sim, S | 1 |
| Chung, WJ; Heo, J; Hwang, JS; Jang, BK; Kim, BS; Kim, SJ; Kweon, YO; Lee, CH; Lee, HJ; Park, SY; Suh, JI; Tak, WY; Woo, HY | 1 |
| Buti-Ferret, M; Edwards, R; Gaggar, A; Gane, E; Jackson, K; Janssen, H; Kitrinos, K; Littlejohn, M; Locarnini, S; Marcellin, P; Revill, P; Subramanian, M; Thompson, A; Wong, D | 1 |
| Chien, RN; Chu, HC; Chuang, WL; Hsu, CW; Huang, YH; Kao, JH; Lee, CM; Liaw, YF; Peng, CY; Su, WW | 1 |
| Chiang, YJ; Chu, YD; Yeh, CS; Yeh, CT | 1 |
| Ayoub, MM; El-Nahas, HM; Elantouny, NG; Ghazy, FES | 1 |
| Cheung, PP; Cho, J | 1 |
| Chen, R; Cheng, Y; Li, Q; Li, X; Liao, H; Liu, L; Liu, Y; Shao, J; Su, H; Xu, D; Zhao, L; Zhao, Y; Zhou, Y | 1 |
| Friedman, A; Siewe, N | 1 |
| Lin, CL | 1 |
| Chien, HC; Fenner, KS; Giacomini, KM; Gupta, A; Prasad, B; Stahl, SH; Stecula, A; Unadkat, JD; Wang, L; Yee, SW; Zou, L | 1 |
| Darsazan, B; Mortazavi, SA; Shafaati, A; Zarghi, A | 1 |
| Česnek, M; Dračínský, M; Janeba, Z; Jansa, P; Mertlíková-Kaiserová, H; Skácel, J; Šmídková, M; Soto-Velasquez, MP; Watts, VJ | 1 |
| Caviglia, GP; Ngatchou, D; Olivero, A; Saracco, GM; Smedile, A | 1 |
| Feenstra, KA; Jansen, L; Kootstra, NA; Reesink, HW; van der Ree, MH; Welkers, MRA | 1 |
| Li, J; Liu, Y; Su, Q | 1 |
| Hashimoto, S; Koike, T; Maoka, T; Okamoto, N; Watanabe, K; Yamamoto, R | 1 |
| Kan, QC; Li, ZQ; Yan, JY; Yu, ZJ | 1 |
| Ahmed, A; Kim, D; Kim, WR; Udompap, P | 1 |
| Beadle, JR; He, R; Hostetler, KY; Khoury, H; Minden, MD; Schimmer, A | 1 |
| Dong, J; Huang, Y; Li, X; Wang, Y; Yu, F; Yu, Z | 1 |
| Naing, C; Poovorawan, Y; Tong, KS | 1 |
| Fan, YC; Qian, Y; Wang, JW; Wang, K; Wu, CS; Zhang, J; Zhao, Q | 1 |
| Fujii, T; Honda, H; Iwaki, T; Kawamura, N; Kira, JI; Takase, KI; Uchiumi, T; Urata, M; Yamasaki, R | 1 |
| Ma, Y; Wang, P; Wei, M; Wu, X; Yang, Y; Zhou, Y | 1 |
| Li, T; Lin, C; Qu, Y; Wang, L; Wang, Y; Yang, B | 1 |
| Hiraoka, A; Izumoto, H; Kitahata, S; Kondoh, K; Michitaka, K; Ninomiya, T; Tsubouchi, E; Ueki, H; Yamago, H | 1 |
| Chang, Y; Cho, EJ; Cho, H; Cho, YY; Kim, YJ; Lee, JH; Nam, JY; Yoon, JH; Yu, SJ | 1 |
| Chen, PD; Fan, QQ; Jia, W; Qi, X; Wang, T; Wen, X; Zhang, JM; Zhang, WH; Zhu, MQ | 1 |
| Li Wai Suen, CFD; Lokan, J; Mills, C; Sinclair, M; Sutherland, N | 1 |
| Lopatin, U | 1 |
| Dai, Z; Fu, X; Han, Y; Li, J; Li, T; Li, Y; Liu, T; Wang, Y; Wu, D; Xiao, T; Yang, Y; Zhao, Y | 1 |
| Fuhr, U; Kinzig, M; Scherf-Clavel, O; Sörgel, F; Stoffel, MS | 1 |
| Cloherty, G; Deerain, J; Gaggar, A; Hammond, R; Kitrinos, K; Leary, T; Locarnini, S; O'Donnell, T; Subramanian, M; Walsh, R; Wong, D; Yuen, L | 1 |
| Chen, H; Ding, Y; Jin, W; Li, C; Li, X; Liu, C; Liu, J; Niu, J; Wu, M; Zhang, D; Zhang, H; Zhu, X | 1 |
| Cai, S; Liao, W; Liu, L; Yin, S; Zheng, Z; Zhu, H | 1 |
| Babudieri, S; Bagella, P; Bandiera, F; Calvisi, DF; Fiore, V; Garrucciu, G; Madeddu, G; Mannu, F; Melis, M; Muredda, AA; Ortu, S; Zaru, S | 1 |
| Heller, T; Hercun, J; Koh, C | 1 |
| Ahn, SH; Bae, SH; Heo, J; Jang, JY; Kim, CW; Kim, DJ; Kim, IH; Park, JY; Tak, WY; Woo, HY | 1 |
| Chen, R; Cheng, F; Duan, C; Huang, B; Li, X; Liu, Y; Luo, D; Si, L; Wang, J; Xu, D | 1 |
| Jang, BK | 1 |
| Li, X; Qin, Y; Tong, S; Wang, T; Zhang, J; Zhao, W | 1 |
| Chen, X; Gan, W; Gao, Z; Li, J; Lin, C; Zhang, C | 1 |
| Enomoto, M; Kawada, N; Nishiguchi, S; Tamori, A; Yoshida, K | 1 |
| Chen, R; Li, J; Li, L; Li, X; Liu, LM; Liu, Y; Shao, J; Xu, D; Zhao, L; Zhou, Y | 1 |
| Chen, R; Li, L; Li, X; Li, Y; Liao, H; Liu, W; Liu, Y; Si, L; Wang, J; Xu, D; Yao, Z; Zhao, J | 1 |
| López Medina, JA; Simón Frapolli, VJ; Tinahones Madueño, FJ | 1 |
| Kudose, S; Lunenfeld, E; Markowitz, GS | 1 |
| Dieterich, D; Roediger, R; Smyth, EK | 1 |
145 review(s) available for adenine and adefovir
| Article | Year |
|---|---|
Chemotherapy of feline immunodeficiency virus infection.
Topics: Adenine; Animals; Antiviral Agents; Cats; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Organophosphonates; Zidovudine | 1991 |
Targeted therapy of human immunodeficiency virus-related disease.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine | 1991 |
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA, Viral; Humans; Organophosphonates; Organophosphorus Compounds | 1991 |
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Retroviridae Infections; Virus Diseases | 1990 |
Biochemical pharmacology of acyclic nucleotide analogues.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; HIV; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds | 1990 |
New acquisitions in the development of anti-HIV agents.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Dideoxynucleosides; Drug Design; HIV; Molecular Structure; Organophosphonates; Polysaccharides; Purines | 1989 |
Anti-retroviral and pharmacological properties of 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenylate Kinase; Animals; Antiviral Agents; Biotransformation; Herpesviridae; Humans; Muscle, Skeletal; Organophosphonates; Phosphorylation; Phosphotransferases; Rabbits; Retroviridae; Structure-Activity Relationship | 1994 |
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Stereoisomerism | 1995 |
Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Drug Interactions; Humans; Infusions, Intravenous; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Insufficiency | 1999 |
Strategies for second-line antiretroviral therapy in adults with HIV infection.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; HIV; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Virus Latency; Virus Replication | 1999 |
[New developments in therapy of chronic hepatitis B. When are nucleoside analogs indicated?].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Transplantation; Long-Term Care; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2000 |
Current limitations to nucleoside analogue therapy for chronic hepatitis B virus infection in the liver transplant and non-transplant settings.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; DNA, Viral; Famciclovir; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Treatment Outcome | 2000 |
Drug therapy for hepatitis B.
Topics: Adenine; Antiviral Agents; Disease Progression; Female; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Male; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors | 2001 |
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.
Topics: 2-Aminopurine; Adenine; Amino Acid Sequence; Animals; Anti-HIV Agents; Antimetabolites; Antiviral Agents; Biological Availability; Cell Line; Clinical Trials as Topic; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Famciclovir; Gene Products, pol; Hepatitis B; Hepatitis B virus; Hepatitis Viruses; Hepatitis, Animal; HIV; Humans; Lamivudine; Models, Animal; Molecular Sequence Data; Molecular Structure; Nucleosides; Organophosphonates; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Virus Replication | 2001 |
[Current knowledge on chronic hepatitis B therapy].
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2001 |
Nucleoside analogues for chronic hepatitis B.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Famciclovir; Ganciclovir; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2001 |
[New management strategies for hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B; Humans; Lamivudine; Organophosphonates | 2002 |
Update on the management of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2002 |
Management of patients with decompensated HBV cirrhosis.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance; Hepatitis B; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Risk Factors | 2003 |
[Treatment of hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Treatment Outcome | 2002 |
[Antiviral therapy for chronic viral hepatitis B and C].
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferon-beta; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Treatment Outcome | 2003 |
Slowing the progression of chronic hepatitis B. Early antiviral therapy can help minimize complications.
Topics: Adenine; Administration, Oral; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Child; Disease Progression; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Interferons; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2003 |
[Hepatitis: associated diseases. Risk groups -- prevention -- treatment].
Topics: Adenine; Adult; Antiviral Agents; Child; DNA, Viral; Female; Hepacivirus; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Humans; Infant; Infant, Newborn; Interferons; Lamivudine; Liver Cirrhosis; Male; Mutation; Organophosphonates; Recurrence; Ribavirin; Risk Factors; RNA, Viral; Time Factors | 2003 |
Current pharmacotherapy for the treatment of chronic hepatitis B.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Clinical Trials as Topic; Famciclovir; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Mutation; Nucleosides; Organophosphonates | 2003 |
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Cidofovir; Cytosine; DNA Virus Infections; DNA Viruses; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Infectious Disease Transmission, Professional-to-Patient; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Physicians; Risk Factors; Risk Management; Tenofovir; Viral Load | 2003 |
Rescue therapy for drug resistant hepatitis B: another argument for combination chemotherapy?
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy | 2004 |
Adefovir (Hepsera) for chronic hepatitis B infection.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates | 2003 |
Combination therapy for chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Vaccines | 2003 |
Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others).
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates | 2003 |
[Adefovir dipivoxil-A new drug for hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B; Humans; Organophosphonates | 2004 |
Metal ion complexes of antivirally active nucleotide analogues. Conclusions regarding their biological action.
Topics: Adenine; Adenine Nucleotides; Animals; Antiviral Agents; Drug Stability; Humans; Ions; Metals; Nucleotides; Organophosphonates; Structure-Activity Relationship; Substrate Specificity; Virus Replication | 2004 |
Hepatitis B virus kinetics and mathematical modeling.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; Hepatocytes; Lamivudine; Models, Biological; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Load; Virion | 2004 |
The role of interferon therapy in hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Patient Selection; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prognosis; Risk Assessment; Risk Factors; Treatment Outcome | 2004 |
Hepatitis C virus in the setting of HIV or hepatitis B virus coinfection.
Topics: Adenine; Antiviral Agents; Comorbidity; Hepacivirus; Hepatitis B virus; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; Risk Factors | 2004 |
[Hepatitis B (acute and chronic)].
Topics: Acute Disease; Adenine; Adolescent; Adult; Antiviral Agents; Child; Diagnosis, Differential; Drug Therapy, Combination; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Risk Factors; Time Factors | 2004 |
Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates | 2004 |
Treatment of chronic viral hepatitis.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
The management of chronic viral hepatitis: a Canadian consensus conference 2004.
Topics: Adenine; Adult; Antiviral Agents; Canada; Child; Child, Preschool; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Hepacivirus; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C Antibodies; Hepatitis C, Chronic; Humans; Infant, Newborn; Interferon-alpha; Lamivudine; Male; Organophosphonates; Polymerase Chain Reaction; Practice Guidelines as Topic; Pregnancy; RNA, Viral; Viral Hepatitis Vaccines | 2004 |
Drug-induced renal failure in the ICU.
Topics: Acute Kidney Injury; Adenine; Amphotericin B; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Calcineurin Inhibitors; Cidofovir; Cyclooxygenase Inhibitors; Cytosine; Foscarnet; Hemodynamics; Humans; Hydroxyethyl Starch Derivatives; Immunoglobulins, Intravenous; Intensive Care Units; Kidney; Organophosphonates; Tacrolimus | 2004 |
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel.
Topics: Adenine; Antiviral Agents; Comorbidity; Deoxycytidine; Disease Progression; Drug Monitoring; Emtricitabine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Tenofovir | 2005 |
[Chronic hepatitis B: which patients should be treated and how?].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Patient Care Planning; Patient Selection; Polyethylene Glycols; Prognosis; Recombinant Proteins | 2005 |
[Management of chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Mutation; Organophosphonates; Patient Selection; Polyethylene Glycols; Recombinant Proteins; Recurrence; Time Factors; Virus Replication | 2005 |
Adefovir-lamivudine combination therapy and hepatitis B viral kinetics.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Virulence | 2005 |
[Clinical and virologic characteristics and treatment for chronic hepatitis B: relation with HBV genotypes].
Topics: Adenine; Antiviral Agents; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Prognosis | 2005 |
[Drug therapy in chronic liver disease].
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Antiviral Agents; Azathioprine; Cholangitis, Sclerosing; Chronic Disease; Drug Therapy, Combination; Fatty Liver; Hemochromatosis; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis, Autoimmune; Hepatolenticular Degeneration; Humans; Immunosuppression Therapy; Interferons; Lamivudine; Liver Cirrhosis, Biliary; Liver Diseases; Organophosphonates; Prednisolone; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ribavirin; Time Factors | 2005 |
Understanding hepatitis B.
Topics: Acute Disease; Adenine; Algorithms; Antiviral Agents; Hepatitis B; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins | 2005 |
Therapeutic options for chronic hepatitis B: considerations and controversies.
Topics: Adenine; Antiviral Agents; Decision Making; DNA, Viral; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome | 2006 |
[Treatment of chronic hepatitis B].
Topics: Adenine; Administration, Oral; Antiviral Agents; Biopsy; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Drug Tolerance; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors; Time Factors; Virus Replication | 2006 |
[Liver transplantation for complications of hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Vaccination; Viral Load; Virus Replication | 2006 |
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.
Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Haplorhini; Hepatitis B; Humans; Liver; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphotransferases; Prodrugs; Randomized Controlled Trials as Topic; Rats | 2006 |
Hepatitis B virus genotypes and response to antiviral therapy.
Topics: Adenine; Antiviral Agents; Genotype; Hepatitis B; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2006 |
Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Nucleotides; Organophosphonates; Recurrence; Tenofovir | 2006 |
Antiviral treatment for chronic hepatitis B virus infection--immune modulation or viral suppression?
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Fibrosis; Genotype; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver Neoplasms; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors | 2006 |
New developments in the treatment of chronic hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Clinical Trials as Topic; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Patient Selection; Polyethylene Glycols; Recombinant Proteins | 2006 |
Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Guanine; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Preventive Medicine; Tenofovir | 2006 |
[Therapy of hepatitis B].
Topics: Adenine; Administration, Oral; Antiviral Agents; Diagnosis, Differential; Hepatitis B, Chronic; Humans; Immunologic Factors; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome | 2006 |
[Therapy of hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Drug Antagonism; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Forecasting; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Organophosphonates; Polyethylene Glycols; Prognosis; Recombinant Proteins; Reverse Transcriptase Inhibitors; Time Factors | 2006 |
[Managing resistance to analogue antiviral drugs in a decompensated cirrhosis patient].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Mutation; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome | 2006 |
[Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients].
Topics: Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2006 |
[Managing lamivudine resistance in liver transplantation for hepatitis B liver disease].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Secondary Prevention; Treatment Outcome | 2006 |
[Impact of resistance to analogue antivirals and therapeutic strategies in situations of dialysis, kidney transplantation, vasculitis, and preemptive treatments in immunosuppressed patients].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Vaccines; Humans; Immunocompromised Host; Kidney Failure, Chronic; Kidney Transplantation; Lamivudine; Organophosphonates; Renal Dialysis; Reverse Transcriptase Inhibitors; Treatment Outcome; Vasculitis | 2006 |
Why adefovir is not yet available in Canada.
Topics: Adenine; Antiviral Agents; Canada; Drug Utilization; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Organophosphonates | 2006 |
Cross-study analysis of the relative efficacies of oral antiviral therapies for chronic hepatitis B infection in nucleoside-naive patients.
Topics: Adenine; Administration, Oral; Algorithms; Antiviral Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome | 2007 |
[Drugs for hepatitis B and C infection].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Mutation; Oligopeptides; Organophosphonates; Proline; Ribavirin; Serine Proteinase Inhibitors | 2007 |
[Advances in research of hepatitis B virus resistance to adefovir].
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Humans; Organophosphonates | 2007 |
Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine | 2007 |
Treatment of chronic hepatitis B in HIV-infected patients in 2007.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2007 |
Chronic hepatitis B with advanced fibrosis or cirrhosis: impact of antiviral therapy.
Topics: Adenine; Antiviral Agents; Disease Progression; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Organophosphonates | 2007 |
Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: a systematic review of economic evidence.
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Databases, Factual; Hepatitis B, Chronic; Humans; Organophosphonates; United States | 2007 |
[Indications for antiviral therapy for chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Biomarkers; Carrier State; Consensus Development Conferences as Topic; DNA, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Japan; Lamivudine; Organophosphonates; Societies, Medical | 2007 |
[Therapy for chronic hepatitis B: relationship between HBV genotype and efficacy or resistance of anti-viral therapy].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2007 |
[Attention-getting sexually transmitted diseases: Hepatitis B].
Topics: Adenine; Adenosine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Genotype; Guanine; Guanosine; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Sexually Transmitted Diseases, Viral | 2007 |
Review article: Success and failure of nucleoside and nucleotide analogues in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Virus Replication | 2007 |
[Pharmacological agents for the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Time Factors; Treatment Outcome | 2008 |
Evaluating anti-viral drug selection and treatment duration in HBeAg-negative chronic hepatitis B: a cost-effectiveness analysis.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Epidemiologic Methods; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2008 |
Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2007 |
The discovery of antiviral agents: ten different compounds, ten different stories.
Topics: Acyclovir; Adenine; Antiviral Agents; Benzodiazepines; Benzylamines; Cidofovir; Cyclams; Cytosine; Heterocyclic Compounds; Humans; Imidazoles; Nucleosides; Organophosphonates; Tenofovir; Valacyclovir; Valine; Virus Diseases | 2008 |
[Treatment recommendations of chronic hepatitis B. Did the world escape us?].
Topics: Adenine; Antiviral Agents; Disease Management; Drug Therapy, Combination; Guanine; Health Planning Guidelines; Health Services Accessibility; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; National Health Programs; Organophosphonates; Poland; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Treatment Outcome | 2008 |
A review of telbivudine for the management of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine | 2008 |
LB80380: a promising new drug for the treatment of chronic hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunologic Factors; Organophosphonates; Practice Guidelines as Topic | 2008 |
[Interferon in hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Multicenter Studies as Topic; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Randomized Controlled Trials as Topic; Recombinant Proteins; Telbivudine; Thymidine; Treatment Outcome | 2008 |
[Resistance in hepatitis B virus].
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Gene Products, pol; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Models, Molecular; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Virus Replication | 2008 |
Role of combination therapy in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Salvage Therapy; Treatment Outcome | 2009 |
Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success.
Topics: Adenine; Adenine Nucleotides; Alanine Transaminase; Carcinoma, Hepatocellular; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Treatment Outcome; Virus Replication | 2008 |
Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Pyrimidinones; Randomized Controlled Trials as Topic; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2008 |
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2009 |
Hepatitis B therapy in children.
Topics: Adenine; Adolescent; Antiviral Agents; Child; Child, Preschool; Drug Therapy, Combination; Hepatitis B; Humans; Infant; Infant, Newborn; Interferon-alpha; Lamivudine; Organophosphonates; Treatment Outcome | 2009 |
Chronic hepatitis B: early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides.
Topics: Adenine; Administration, Oral; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Time Factors; Treatment Outcome | 2009 |
On-treatment outcome prediction and adjustment during chronic hepatitis B therapy: now and future.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Medication Adherence; Nucleosides; Organophosphonates; Polyethylene Glycols; Prognosis; Pyrimidinones; Recombinant Proteins; Telbivudine; Thymidine; Time Factors; Treatment Outcome | 2009 |
[Chronic hepatitis B: current therapy].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Immunotherapy, Active; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome | 2008 |
The option of liver transplantation for hepatitis B: where are we?
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Postoperative Complications; Practice Guidelines as Topic; Secondary Prevention; Viral Load | 2009 |
Liver transplantation for hepatitis B virus. Pre-emptive and peri-operative prophylaxis.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Perioperative Care; Postoperative Complications; Secondary Prevention; Treatment Outcome | 2009 |
Prevention of recurrent hepatitis B virus infection after liver transplantation: hepatitis B immunoglobulin, antiviral drugs, or both? Systematic review and meta-analysis.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome | 2010 |
Lenalidomide-induced acute liver failure.
Topics: Adenine; Aged, 80 and over; Antineoplastic Agents; Antiviral Agents; Hepatitis B, Chronic; Humans; Lenalidomide; Liver Failure, Acute; Male; Myelodysplastic Syndromes; Organophosphonates; Thalidomide | 2009 |
Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion.
Topics: Adenine; Adjuvants, Immunologic; Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Randomized Controlled Trials as Topic; Risk Assessment; Serologic Tests; Severity of Illness Index; Tenofovir; Treatment Outcome | 2010 |
Avoiding and managing lamivudine resistance in chronic hepatitis B: current approaches and potential strategies including pegylated interferon.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B infection.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Cost-Benefit Analysis; Disease Progression; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Models, Economic; Organophosphonates; Quality of Life; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; United Kingdom | 2010 |
Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2010 |
Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection.
Topics: Adenine; Animals; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Recombinant Proteins; Treatment Outcome | 2011 |
Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2011 |
Hepatitis B virus resistance to antiviral drugs: where are we going?
Topics: Adenine; Antiviral Agents; Capsid; Clinical Protocols; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Virus Internalization; Virus Replication | 2011 |
The impact of human immunodeficiency virus on viral hepatitis.
Topics: Adenine; Antiviral Agents; Deoxycytidine; Disease Progression; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B; Hepatitis C; Hepatitis Viruses; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
[Treatment of patients with lamivudine-resistant chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2011 |
Comparison of the 48-week efficacy between entecavir and adefovir in HBeAg-positive nucleos(t)ide-naïve Asian patients with chronic hepatitis B: a meta-analysis.
Topics: Adenine; Antiviral Agents; Asia; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic | 2011 |
Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review.
Topics: Adenine; Antiviral Agents; Controlled Clinical Trials as Topic; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
[Progress and perspectives in treatment of chronic hepatitis B].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2011 |
Lamivudine plus adefovir combination therapy versus entecavir monotherapy for lamivudine-resistant chronic hepatitis B: a systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Organophosphonates; Salvage Therapy; Time Factors; Treatment Outcome; Viral Load | 2011 |
Application of kinase bypass strategies to nucleoside antivirals.
Topics: Adenine; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytosine; History, 20th Century; History, 21st Century; Humans; Nucleosides; Nucleotides; Organophosphonates; Phosphotransferases; Tenofovir | 2011 |
Antiviral drugs for viruses other than human immunodeficiency virus.
Topics: Acyclovir; Adenine; Amantadine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Foscarnet; Ganciclovir; Guanine; Hepatitis; Hepatitis B, Chronic; Hepatitis C; Herpesviridae Infections; HIV Infections; Humans; Influenza, Human; Interferons; Lamivudine; Nucleosides; Oligopeptides; Organophosphonates; Oseltamivir; Proline; Protease Inhibitors; Pyrimidinones; Ribavirin; Telbivudine; Thymidine; Valacyclovir; Valganciclovir; Valine; Virus Replication; Zanamivir | 2011 |
[The past, present and future treatment for chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Practice Guidelines as Topic | 2011 |
[Prevention for the development of hepatitis B virus-related hepatocellular carcinoma by anti-viral treatment].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Organophosphonates | 2011 |
Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome; Viral Load | 2012 |
Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review.
Topics: Adenine; Bone and Bones; Dose-Response Relationship, Drug; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Radionuclide Imaging; Tomography, X-Ray Computed | 2013 |
[Comparison of peg-interferon monotherapy to peg-interferon and nucleoside analogue combination therapy for hepatitis B: a meta-analysis of randomized controlled trials].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Treatment Outcome | 2012 |
Considerations for the long-term treatment of chronic hepatitis B with nucleos(t)ide analogs.
Topics: Adenine; Age Factors; Antiviral Agents; Comorbidity; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Life Style; Organophosphonates; Severity of Illness Index; Telbivudine; Tenofovir; Thymidine; Time Factors | 2012 |
Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Mutation; Nucleosides; Nucleotides; Organophosphonates; Prognosis; Tenofovir; Viral Load | 2012 |
Treatment of delta hepatitis.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Farnesyl-Diphosphate Farnesyltransferase; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Protein Prenylation; Recombinant Proteins; Viral Proteins; Virus Replication | 2013 |
Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B.
Topics: Adenine; Administration, Oral; Age Factors; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Incidence; Liver Neoplasms; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2013 |
[Interdisciplinary aspects of and new drugs for chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Comorbidity; Drug Interactions; Drug Therapy, Combination; Female; Gastroenterology; Guanine; Hematology; Hepatitis B, Chronic; Humans; Hungary; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease Transmission, Vertical; Interdisciplinary Communication; Interferons; Lamivudine; Medical Oncology; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Rheumatology; Tenofovir | 2013 |
The Holý Trinity: the acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Humans; Nucleosides; Organophosphonates; Prodrugs; Tenofovir; Virus Diseases | 2013 |
Comparison of the efficacy of Lamivudine plus adefovir versus entecavir in the treatment of Lamivudine-resistant chronic hepatitis B: a systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Treatment Outcome | 2013 |
Review article: nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Renal Insufficiency, Chronic; Telbivudine; Tenofovir; Thymidine | 2014 |
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Organophosphonates; Pharmacovigilance; Pregnancy; Telbivudine; Tenofovir; Thymidine | 2014 |
HBeAg-positive chronic hepatitis B: why do i treat my patients with Nucleos(t)ide analogs?
Topics: Adenine; Age Factors; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Precision Medicine; Recombinant Proteins; Sex Factors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2014 |
Impact of HBV therapy on the incidence of hepatocellular carcinoma.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Tenofovir | 2014 |
New therapeutic perspectives in HBV: when to stop NAs.
Topics: Adenine; Algorithms; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine | 2014 |
Clinical utility of entecavir for chronic hepatitis B in Chinese patients.
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Liver Transplantation; Organophosphonates | 2013 |
Management of chronic hepatitis B in children: an unresolved issue.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Carrier State; Child; Databases, Bibliographic; Guanine; Hepatitis B, Chronic; Humans; Immune Tolerance; Incidence; Interferons; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Risk; Tenofovir | 2014 |
Entecavir plus adefovir combination therapy versus lamivudine add-on adefovir for lamivudine-resistant chronic hepatitis B: A meta-analysis.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2014 |
Monotherapy for hepatitis B infection: a review of treatment options.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Neoplasms; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2015 |
HBsAg seroclearance or seroconversion induced by peg-interferon alpha and lamivudine or adefovir combination therapy in chronic hepatitis B treatment: a meta-analysis and systematic review.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Seroconversion | 2016 |
Systematic review with network meta-analysis: Comparative efficacy of oral nucleos(t)ide analogues for the prevention of chemotherapy-induced hepatitis B virus reactivation.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Controlled Clinical Trials as Topic; Guanine; Hepatitis B; Hepatitis B virus; Host-Pathogen Interactions; Humans; Lamivudine; Organophosphonates; Telbivudine; Thymidine; Virus Activation | 2016 |
A Meta-Analysis of the Efficacy of Interferon Monotherapy or Combined with Different Nucleos(t)ide Analogues for Chronic Hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Odds Ratio; Organophosphonates; Treatment Outcome | 2016 |
Management of Antiviral Resistance in Chronic Hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Tenofovir | 2017 |
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; Humans; Nucleosides; Nucleotides; Organophosphonates; Prodrugs | 2017 |
Nucleos(t)ide analogues for preventing HBV reactivation in immunosuppressed patients with hematological malignancies: a network meta-analysis.
Topics: Adenine; Antiviral Agents; Controlled Clinical Trials as Topic; Guanine; Hematologic Neoplasms; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Lamivudine; Organophosphonates; Survival Analysis; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Activation | 2017 |
Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Retrospective Studies; Survival Analysis; Telbivudine; Tenofovir; Thymidine | 2017 |
Combination Therapy for Chronic Hepatitis B: Current Updates and Perspectives.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Viral Load | 2017 |
Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes.
Topics: Adenine; Animals; Antiviral Agents; Cell Membrane; Cetrimonium; Cetylpyridinium; Humans; Intestinal Mucosa; Ions; Organophosphonates; Prodrugs; Quaternary Ammonium Compounds | 2018 |
Comparative effectiveness of anti-viral drugs with dual activity for treating hepatitis B and HIV co-infected patients: a network meta-analysis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Coinfection; Emtricitabine; Female; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Network Meta-Analysis; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2018 |
Drugs in the Pipeline for HBV.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Forecasting; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Assessment; Tenofovir; Treatment Outcome; Virus Replication | 2019 |
Hepatitis Delta: Prevalence, Natural History, and Treatment Options.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Biomarkers; Carcinoma, Hepatocellular; Global Health; Hepatitis D; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Interferon alpha-2; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Organophosphonates; Prevalence; Risk; RNA, Viral; Serologic Tests | 2020 |
Combination of Entecavir or Tenofovir with Pegylated Interferon-α for Long-Term Reduction in Hepatitis B Surface Antigen Levels: Simultaneous, Sequential, or Add-on Combination Therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Reproducibility of Results; Tenofovir; Treatment Outcome; Viral Load | 2021 |
Adefovir for lamivudine-resistant hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B; Humans; Lamivudine; Organophosphonates | 2022 |
112 trial(s) available for adenine and adefovir
| Article | Year |
|---|---|
Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms.
Topics: Adenine; Animals; Antiviral Agents; Cats; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Feline Acquired Immunodeficiency Syndrome; Gene Products, gag; Hematocrit; Immunodeficiency Virus, Feline; Injections, Subcutaneous; Leukemia Virus, Feline; Leukemia, Feline; Organophosphonates; T-Lymphocytes, Regulatory; Zidovudine | 1992 |
Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Biological Availability; Female; Half-Life; HIV Infections; HIV-1; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Organophosphonates; Protein Binding | 1995 |
Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection: a pilot study.
Topics: Acquired Immunodeficiency Syndrome; Adenine; AIDS-Related Complex; Alanine Transaminase; Aspartate Aminotransferases; CD4-Positive T-Lymphocytes; HIV Infections; Humans; Immunosuppressive Agents; Injections, Intravenous; Leukocyte Count; Organophosphonates | 1996 |
[Comparative investigation of the efficacy of two nucleocapsid analogs in FIV infected cats].
Topics: Adenine; Animals; Antiviral Agents; Cats; Double-Blind Method; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Organophosphonates; Organophosphorus Compounds; Placebos; Treatment Outcome | 1997 |
Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus.
Topics: Adenine; Animals; Antiviral Agents; Cats; CD4 Lymphocyte Count; Double-Blind Method; Feline Acquired Immunodeficiency Syndrome; Female; Karnofsky Performance Status; Male; Organophosphonates; Placebos; Reference Standards; Stomatitis; Viral Load | 1998 |
Effect of weekly adefovir (PMEA) infusions on HIV-1 virus load: results of a phase I/II study.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Antiviral Agents; CD4 Lymphocyte Count; HIV-1; Humans; Male; Middle Aged; Organophosphonates; RNA, Viral | 1999 |
Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS Clinical Trials Group Study 359.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Nelfinavir; Organophosphonates; Prospective Studies; Ritonavir; RNA, Viral; Saquinavir | 2000 |
Competing drug-drug interactions among multidrug antiretroviral regimens used in the treatment of HIV- infected subjects: ACTG 884.
Topics: Adenine; Adult; Anti-HIV Agents; Delavirdine; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Nelfinavir; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir | 2000 |
And also, "adefovir dipovixil".
Topics: Adenine; Antiviral Agents; Biological Availability; CD4 Lymphocyte Count; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 1996 |
Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408.
Topics: Adenine; Anti-HIV Agents; Double-Blind Method; Genes, Viral; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir | 2001 |
The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Cytomegalovirus Infections; Double-Blind Method; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral | 2001 |
HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Composition; Carnitine; Dideoxynucleosides; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hydroxyurea; Insulin Resistance; Lipodystrophy; Male; Middle Aged; Nevirapine; Organophosphonates; Quality of Life; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome | 2001 |
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Nelfinavir; Organophosphonates; Oxazines; Treatment Failure | 2003 |
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359.
Topics: Adenine; Adult; Anti-HIV Agents; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Nelfinavir; Organophosphonates; Ritonavir; RNA, Viral; Saquinavir; Sex Factors | 2004 |
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection.
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Hepatitis B, Chronic; HIV Infections; Humans; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Organophosphonates; Reference Standards; Reproducibility of Results; Solutions; Spectrophotometry, Ultraviolet | 2005 |
Determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis B virus-related decompensated liver cirrhosis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatic Encephalopathy; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Mutation; Organophosphonates; Survival Analysis; Taiwan | 2005 |
Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Dietary Fats; Double-Blind Method; Food-Drug Interactions; Humans; Male; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2005 |
A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; China; DNA, Viral; Double-Blind Method; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2006 |
Overlap lamivudine treatment in patients with chronic hepatitis B receiving adefovir for lamivudine-resistant viral mutants.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load | 2006 |
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2006 |
Low risk of hepatitis B virus recurrence after withdrawal of long-term hepatitis B immunoglobulin in patients receiving maintenance nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Liver Transplantation; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Risk Factors; Secondary Prevention; Treatment Outcome | 2007 |
Hepatitis B virus resistance to adefovir in a nucleotide naive patient with chronic hepatitis B virus infection.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Mutation; Organophosphonates; Virus Replication | 2007 |
Absence of a pharmacokinetic interaction between entecavir and adefovir.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Area Under Curve; Cross-Over Studies; Drug Interactions; Female; Guanine; Humans; Male; Organophosphonates | 2007 |
Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viremia | 2007 |
Cost effectiveness of entecavir versus lamivudine with adefovir salvage in HBeAg-positive chronic hepatitis B.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Cohort Studies; Cost-Benefit Analysis; Disease Progression; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Organophosphonates; Quality of Life; Salvage Therapy | 2007 |
Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients.
Topics: Adenine; Adult; Aged; Antiviral Agents; Disease Progression; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Risk Factors; Survival Analysis; Treatment Outcome | 2007 |
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations.
Topics: Adenine; Adult; Aged; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Viral Load | 2008 |
Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Circular; DNA, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Immunohistochemistry; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Risk Assessment; Risk Factors; Secondary Prevention; Sequence Analysis, DNA; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2008 |
Dynamics of lamivudine-resistant hepatitis B virus during adefovir monotherapy versus lamivudine plus adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors | 2008 |
Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Tenofovir; Treatment Outcome; Viral Load | 2008 |
A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Patient Selection; Postoperative Complications; Viral Load | 2008 |
Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Viral Load | 2009 |
Failure of adefovir 20 mg to improve suboptimal response in lamivudine-resistant hepatitis B patients treated with adefovir 10 mg and lamivudine.
Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2008 |
Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Treatment Outcome | 2009 |
Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Treatment Outcome; Young Adult | 2009 |
Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Prospective Studies; Reverse Transcriptase Inhibitors; Virus Replication | 2010 |
Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2010 |
[Comparison of the efficacy of 48 week-Entecavir therapy with that of Adefovir therapy for chronic hepatitis B patients].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2010 |
Overlap/switch to adefovir monotherapy for lamivudine-resistant patients who responded to combination therapy: a pilot controlled study.
Topics: Adenine; Adult; Aged; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects | 2010 |
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.
Topics: Adenine; Administration, Oral; Antiviral Agents; Chromatography, Liquid; Drug Stability; Humans; Limit of Detection; Male; Organophosphonates; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Thiazolidines; Time Factors | 2010 |
Question of ALT flare during switch to adefovir from lamivudine: A single center open-label, randomized, safety study (June 17, 2005 to February 5, 2009).
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Drug Substitution; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2010 |
[Effect of adefovir and lamivudine combination therapy on lamivudine resistance chronic hepatitis B patients for 48 weeks].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2010 |
[Add on lamivudine to adefovir monotherapy for the treatment of lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2010 |
Efficacy of adefovir add-on lamivudine rescue therapy compared with switching to entecavir monotherapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2010 |
Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Aged, 80 and over; DNA, Viral; Drug Resistance, Viral; Epidemiologic Methods; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load; Young Adult | 2011 |
[Efficacy of adefovir treatment in the lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Treatment Failure; Young Adult | 2010 |
Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inflammation; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Pilot Projects; Prospective Studies; Reverse Transcriptase Inhibitors; Young Adult | 2011 |
Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study.
Topics: Adenine; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Failure; Male; Middle Aged; Organophosphonates; Survival Rate; Treatment Outcome | 2011 |
Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Biopsy; Chi-Square Distribution; DNA, Circular; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Interferon-alpha; Liver; Male; Middle Aged; Netherlands; Organophosphonates; Polyethylene Glycols; Polymerase Chain Reaction; Predictive Value of Tests; Recombinant Proteins; Time Factors; Treatment Outcome; Viral Load | 2011 |
[Safety and efficacy of Entecavir combined with Adefovir in patients with chronic hepatitis B who fail to respond to nucleoside analog treatment].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Treatment Failure | 2011 |
Randomised clinical trial: efficacy of peginterferon alfa-2a in HBeAg positive chronic hepatitis B patients with lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; China; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Time Factors; Treatment Outcome; Young Adult | 2011 |
Simple scoring system predicting genotypic resistance during rescue therapy for Lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Retrospective Studies; Survival Analysis; Treatment Outcome; Young Adult | 2012 |
Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; Cells, Cultured; Chi-Square Distribution; Cytokines; Drug Therapy, Combination; Europe; Female; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon-alpha; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2011 |
Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; Recurrence; Salvage Therapy; Treatment Outcome; Withholding Treatment | 2011 |
Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis.
Topics: Adenine; Aged; Antiviral Agents; Cohort Studies; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Proportional Hazards Models; Prospective Studies; Risk Factors; Severity of Illness Index; Survival Rate; Treatment Outcome | 2011 |
Long-term adefovir plus lamivudine therapy does not decrease creatinine clearance in HBeAg-negative chronic hepatitis B patients.
Topics: Adenine; Adult; Age Factors; Aged; Creatine; Drug Resistance, Viral; Drug Therapy, Combination; Female; Greece; Hepatitis B; Hepatitis B e Antigens; Humans; Kidney; Lamivudine; Linear Models; Male; Middle Aged; Organophosphonates | 2011 |
[Efficacy of two nucleoside analogs to treat resistant HBeAg-negative chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2011 |
The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment.
Topics: Adenine; Adult; Alanine Transaminase; Amino Acid Motifs; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Humans; Lamivudine; Liver Function Tests; Male; Mutation; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
[Clinical antiviral effects of Peg-IFNa-2a in patients with chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2011 |
Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir.
Topics: Adenine; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Therapy, Combination; Ethnicity; Follow-Up Studies; Genetic Variation; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Organophosphonates; Polyethylene Glycols; Polymorphism, Single Nucleotide; Prospective Studies; Recombinant Proteins; Treatment Outcome | 2012 |
Treatment response and evolution of HBV resistance during lamivudine plus adefovir or entecavir therapy in patients with adefovir-resistant mutants.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Cloning, Molecular; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2012 |
Randomized trial of entecavir plus adefovir in patients with lamivudine-resistant chronic hepatitis B who show suboptimal response to lamivudine plus adefovir.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
[Entecavir 1.0mg monotherapy or entecavir plus adefovir dipivoxil for patients with lamivudine-resistant chronic hepatitis B had suboptimal response to lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2011 |
Randomised clinical trial: the benefit of combination therapy with adefovir and lamivudine for chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2012 |
[Efficacy of lamivudine and adefovir de novo combination therapy or after mono-therapy in chronic hepatitis B patients].
Topics: Adenine; Adult; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Treatment Outcome | 2012 |
Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection.
Topics: Adenine; Adolescent; Adult; Aged; Aleutian Mink Disease Virus; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis D; Humans; Interferon-alpha; Kidney; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; Young Adult | 2012 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: adefovir monotherapy, adefovir plus lamivudine or entecavir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Time Factors | 2012 |
Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir.
Topics: Adenine; Adult; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Nucleosides; Organophosphonates; Prospective Studies; Pyrimidinones; Telbivudine; Thymidine; Treatment Outcome; Young Adult | 2012 |
Clonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genome, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2013 |
Randomized trial of lamivudine, adefovir, and the combination in HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors | 2012 |
Sustained efficacy of adefovir add-on therapy in chronic hepatitis B patient with a poor virological response to peginterferon alfa.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Treatment Outcome; Viral Load | 2013 |
Augmentation of hepatitis B virus-specific cellular immunity with programmed death receptor-1/programmed death receptor-L1 blockade in hepatitis B virus and HIV/hepatitis B virus coinfected patients treated with adefovir.
Topics: Adenine; Adult; Antiviral Agents; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Double-Blind Method; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Immunity, Cellular; Male; Middle Aged; Organophosphonates; Programmed Cell Death 1 Receptor; Prospective Studies; T-Lymphocytes, Regulatory; Viral Load; Viremia | 2013 |
Adding adefovir vs. switching to entecavir for lamivudine-resistant chronic hepatitis B (ACE study): a 2-year follow-up randomized controlled trial.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Immunoassay; Lamivudine; Male; Middle Aged; Oligonucleotides; Organophosphonates; Prospective Studies; Republic of Korea; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Treatment Outcome | 2013 |
Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic hepatitis B virus infected patients.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Killer Cells, Natural; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily C; Organophosphonates; Phosphorous Acids; Receptors, KIR2DL3 | 2012 |
Combination of lamivudine and adefovir without hepatitis B immune globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen-positive liver transplant candidates.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Disease-Free Survival; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Kaplan-Meier Estimate; Lamivudine; Liver Transplantation; Male; Middle Aged; New South Wales; New Zealand; Organophosphonates; Prospective Studies; Risk Factors; Secondary Prevention; Time Factors; Treatment Outcome; Victoria; Viral Load; Young Adult | 2013 |
Extended treatment with peginterferon α-2a in combination with lamivudine or adefovir for 96 weeks yields high rates of HBeAg and HBsAg seroconversion.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2013 |
Baseline hepatitis B surface antigen (HBsAg) as predictor of sustained HBsAg loss in chronic hepatitis B patients treated with pegylated interferon-α2a and adefovir.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biopsy; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Viral Load; Young Adult | 2013 |
Randomized trial of the virologic response during up to two years of entecavir-adefovir combination therapy in multiple-drug-refractory chronic hepatitis B virus patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2013 |
Similar evolution of hepatitis B virus quasispecies in patients with incomplete adefovir response receiving tenofovir/emtricitabine combination or tenofovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Evolution, Molecular; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phylogeny; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Treatment Failure; Young Adult | 2013 |
Telbivudine and adefovir combination therapy for patients with chronic lamivudine-resistant hepatitis B virus infections.
Topics: Adenine; Adult; Aged; Antibodies, Viral; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2014 |
[Efficacy and safety of peginterferon alfa-2a (40 kd) plus adefovir for 96 weeks in HBeAg-negative chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome | 2013 |
Antiviral treatment improves disrupted peripheral B lymphocyte homeostasis in chronic hepatitis B virus-infected patients.
Topics: Adenine; Adult; Antiviral Agents; B-Lymphocytes; Female; Flow Cytometry; Hepatitis B, Chronic; Homeostasis; Humans; Liver Diseases; Male; Organophosphonates; Tenofovir; Viral Load; Virus Replication | 2013 |
De novo combination therapy adefovir plus lamivudine as a treatment for women of child-bearing age with HBeAg-positive chronic hepatitis B before pregnancy.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Disease Transmission, Infectious; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2014 |
Add-on peg-interferon leads to loss of HBsAg in patients with HBeAg-negative chronic hepatitis and HBV DNA fully suppressed by long-term nucleotide analogs.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins | 2013 |
Experimental HBsAg/anti-HBs complex assay for prediction of HBeAg loss in chronic hepatitis B patients treated with pegylated interferon and adefovir.
Topics: Adenine; Adult; Antigen-Antibody Complex; Antiviral Agents; Area Under Curve; DNA, Viral; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Predictive Value of Tests; Protein Array Analysis; Protein Binding; Recombinant Proteins; Treatment Outcome | 2014 |
Long-term efficacy and safety of emtricitabine plus tenofovir DF vs. tenofovir DF monotherapy in adefovir-experienced chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome; Viral Load; Viremia | 2014 |
Maintaining remission in lamivudine-resistant patients with a virological response to adefovir add-on lamivudine after stopping lamivudine therapy.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Organophosphonates; Polymerase Chain Reaction; Treatment Outcome; Ultrasonography; Viral Load | 2014 |
The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; China; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Telbivudine; Thymidine; Time Factors; Treatment Outcome; Young Adult | 2014 |
Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Substitution; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Patient Selection; Prospective Studies; Republic of Korea; Telbivudine; Thymidine; Time Factors; Treatment Failure; Viral Load; Young Adult | 2013 |
Non-interventional study AI463-12 of real-world chronic HBV infection management--baseline characteristics and treatment patterns of Polish patients kohort.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Europe; Female; Guanine; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Poland; Practice Guidelines as Topic; Retrospective Studies; Socioeconomic Factors; Treatment Outcome | 2013 |
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.
Topics: Adenine; Adult; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; p-Aminohippuric Acid; Penicillin G; Probenecid; Young Adult | 2014 |
Antiviral therapy improves postoperative survival in patients with hepatocellular carcinoma: a randomized controlled trial.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Hepatitis B; Hepatitis B, Chronic; Humans; Liver Failure; Liver Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Organophosphonates; Prospective Studies; Survival Analysis; Virus Activation; Young Adult | 2015 |
Combination therapy with pegylated interferon alpha-2b and adefovir dipivoxil in HBeAg-positive chronic hepatitis B versus interferon alone: a prospective, randomized study.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins | 2014 |
Entecavir plus adefovir versus adefovir plus lamivudine in hepatitis B virus e antigen-positive, lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Young Adult | 2014 |
Tenofovir monotherapy versus tenofovir and entecavir combination therapy in adefovir-resistant chronic hepatitis B patients with multiple drug failure: results of a randomised trial.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Republic of Korea; Tenofovir; Treatment Outcome | 2016 |
Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2015 |
Association Between Level of Hepatitis D Virus RNA at Week 24 of Pegylated Interferon Therapy and Outcome.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; DNA, Viral; Female; Hepatitis B Surface Antigens; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Placebos; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Transaminases; Treatment Outcome; Viral Load | 2015 |
[Treatment options in HBeAg-positive chronic hepatitis B patients with a poor response to 24-week interferon monotherapy].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferons; Organophosphonates | 2015 |
Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues.
Topics: Adenine; Adult; Amantadine; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reproducibility of Results; RNA, Viral; Tenofovir; Virion | 2016 |
[A randomized controlled trial on 240-week monotherapy with entecavir or adefovir in patients with chronic hepatitis B and cirrhosis].
Topics: Adenine; Aged; Alanine Transaminase; alpha-Fetoproteins; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Organophosphonates; Time Factors | 2015 |
Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial.
Topics: Adenine; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2016 |
Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Intention to Treat Analysis; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Tenofovir; Viral Load; Young Adult | 2017 |
Evaluating the efficacy of switching from lamivudine plus adefovir to tenofovir disoproxil fumarate monotherapy in lamivudine-resistant stable hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Phosphorous Acids; Prospective Studies | 2018 |
ALT flares during nucleotide analogue therapy are associated with HBsAg loss in genotype A HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir; Young Adult | 2018 |
Phase IV randomized clinical study: Peginterferon alfa-2a with adefovir or entecavir pre-therapy for HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Taiwan | 2018 |
Combined effect of pegylated interferon α with adefovir on renal function in Chinese patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; China; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Interferon-alpha; Kidney; Male; Organophosphonates; Prospective Studies; Treatment Outcome | 2018 |
Predicting HBsAg clearance in genotype A chronic hepatitis B using HBsAg epitope profiling: A biomarker for functional cure.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Double-Blind Method; Epitope Mapping; Epitopes; Female; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Seroconversion; Tenofovir; Viral Load | 2019 |
Safety, efficacy, and pharmacokinetics of pradefovir for the treatment of chronic hepatitis B infection.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tenofovir; Treatment Outcome; Viral Load | 2020 |
Mitochondrial toxicity and body shape changes during nucleos(t)ide analogues administration in patients with chronic hepatitis B.
Topics: Adenine; Adiposity; Antiviral Agents; Cross-Sectional Studies; DNA, Mitochondrial; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Mitochondria; Organophosphonates; RNA, Mitochondrial; Tenofovir | 2020 |
Entecavir+tenofovir vs. lamivudine/telbivudine+adefovir in chronic hepatitis B patients with prior suboptimal response.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Sustained Virologic Response; Telbivudine; Tenofovir | 2020 |
Efficacy of 104-week Telbivudine-based optimization strategy in patients with HBeAg-negative chronic hepatitis B virus infections.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; China; Creatinine; DNA, Viral; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Sustained Virologic Response; Telbivudine | 2020 |
687 other study(ies) available for adenine and adefovir
| Article | Year |
|---|---|
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Benzodiazepines; CD4 Antigens; Cytokines; Didanosine; Doxorubicin; Drug Interactions; HIV; HIV Infections; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphocytes; Macrophages; Monocytes; Organ Specificity; Organophosphonates; Zalcitabine; Zidovudine | 1992 |
Cell-protecting effect against herpes simplex virus-1 and cellular metabolism of 9-(2-phosphonylmethoxyethyl)adenine in HeLa S3 cells.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Drug Stability; HeLa Cells; Humans; Hydrogen-Ion Concentration; Organophosphonates; Phosphorylation; Simplexvirus; Solubility; Subcellular Fractions; Time Factors; Tritium; Tumor Cells, Cultured | 1992 |
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Drug Evaluation, Preclinical; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 1992 |
Evaluation of 9-(2-phosphonylmethoxyethyl) adenine therapy for feline immunodeficiency virus using a quantitative polymerase chain reaction.
Topics: Adenine; Animals; Antibodies, Viral; Antigens, Viral; Antiviral Agents; Base Sequence; Cats; DNA, Viral; Drug Administration Schedule; Drug Evaluation; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Injections, Subcutaneous; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Virus Replication | 1992 |
Inhibition of reverse transcriptase from feline immunodeficiency virus by analogs of 2'-deoxyadenosine-5'-triphosphate.
Topics: Adenine; Antiviral Agents; Cell Line; Cells, Cultured; Dideoxyadenosine; Immunodeficiency Virus, Feline; Kinetics; Organophosphonates; Reverse Transcriptase Inhibitors; Templates, Genetic | 1992 |
Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells.
Topics: Adenine; Adenylate Kinase; Animals; Creatine Kinase; Isoelectric Point; Leukemia L1210; Mice; Molecular Weight; Organophosphonates; Organophosphorus Compounds; Substrate Specificity; Time Factors; Tumor Cells, Cultured | 1992 |
Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection.
Topics: Adenine; Animals; Antiviral Agents; Cats; Chromatography, High Pressure Liquid; Humans; Macaca mulatta; Organophosphonates; Organophosphorus Compounds | 1992 |
Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK- herpes simplex virus experimental keratitis.
Topics: Adenine; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Disease Models, Animal; Keratitis, Dendritic; Organophosphonates; Rabbits; Simplexvirus | 1991 |
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; Herpes Simplex; Immune Tolerance; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Opportunistic Infections; Organophosphonates; Organophosphorus Compounds | 1991 |
Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
Topics: Adenine; Animals; Antibodies, Viral; Antigens, Viral; Antiviral Agents; Cats; Cell Line; Feline Acquired Immunodeficiency Syndrome; Leukemia Virus, Feline; Neutralization Tests; Organophosphonates; T-Lymphocytes | 1991 |
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits.
Topics: Adenine; Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Hempa; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Thymidine Kinase | 1991 |
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin | 1990 |
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Cattle; Cell Line; DNA Polymerase II; HIV; Humans; Kinetics; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Ribose-Phosphate Pyrophosphokinase; Thymus Gland; Tritium | 1991 |
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models.
Topics: Adenine; Animals; Antiviral Agents; Cytotoxicity, Immunologic; Interferon-alpha; Interferon-beta; Interferons; Interleukin-1; Interleukin-2; Interleukins; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Organophosphonates; Spleen | 1991 |
Cellular uptake of phosphonylmethoxyalkylpurine derivatives.
Topics: Adenine; Antiviral Agents; Cell Line; Diffusion; Humans; Organophosphonates; Organophosphorus Compounds | 1991 |
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Cell Transformation, Viral; Drug Administration Schedule; Injections, Intraperitoneal; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental | 1991 |
Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection.
Topics: Adenine; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Male; Organophosphonates; Rats; Rats, Inbred Strains; Reproducibility of Results; Spectrometry, Fluorescence | 1991 |
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; HeLa Cells; Humans; Kinetics; Molecular Structure; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Simplexvirus; Structure-Activity Relationship; Vero Cells | 1991 |
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives.
Topics: Adenine; Antiviral Agents; In Vitro Techniques; Kinetics; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Ribose-Phosphate Pyrophosphokinase; Substrate Specificity | 1991 |
Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice.
Topics: Adenine; Animals; Antiviral Agents; Embryo, Mammalian; Female; Fetal Resorption; Litter Size; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Mice, Transgenic; Moloney murine leukemia virus; Organophosphonates; Pregnancy; Viremia; Zidovudine | 1991 |
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Blotting, Western; Cell Line; HIV Envelope Protein gp120; Humans; Macaca mulatta; Membrane Glycoproteins; Molecular Structure; Organophosphonates; Retroviridae; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tissue Distribution; Viral Envelope Proteins; Virus Replication | 1991 |
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis.
Topics: Adenine; Antiviral Agents; DNA Replication; DNA, Viral; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1990 |
Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Humans; Indicators and Reagents; Macrophages; Molecular Structure; Monocytes; Organophosphonates; Polymers; Simplexvirus | 1990 |
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportunistic Infections; Organophosphonates; Retroviridae; Retroviridae Infections; T-Lymphocytes; Virus Replication; Zidovudine | 1990 |
Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Topics: Adenine; Adenosine Triphosphate; Animals; Antiviral Agents; Guanylate Kinases; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Nucleoside-Phosphate Kinase; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Tissue Extracts | 1990 |
Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease.
Topics: Adenine; Animals; Antiviral Agents; Culture Techniques; Drug Resistance, Microbial; Herpesviridae Infections; Herpesvirus 1, Equid; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Viral Plaque Assay; Virus Replication | 1990 |
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Dideoxynucleotides; DNA Polymerase I; DNA Polymerase II; DNA Replication; HeLa Cells; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Thymine Nucleotides; Zidovudine | 1990 |
Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Ribonucleotide Reductases; Simplexvirus | 1990 |
Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.
Topics: Acyclovir; Adenine; Animals; Bromodeoxyuridine; Drug Resistance, Microbial; Mutation; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Vero Cells; Virus Replication | 1990 |
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus.
Topics: Adenine; Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental; Skull Neoplasms; Zidovudine | 1990 |
The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Antiviral Agents; Cell Division; DNA; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1990 |
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.
Topics: Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HIV-1; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Neoplasm Transplantation; Organophosphonates; Retroviridae; Sarcoma, Experimental; Time Factors; Zidovudine | 1990 |
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV-1; Organophosphonates; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine | 1989 |
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Concanavalin A; Herpes Simplex; Interferons; Mice; Mice, Inbred C57BL; Mitogens; Opportunistic Infections; Organophosphonates; Spleen; Zidovudine | 1989 |
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.
Topics: Adenine; Animals; Antiviral Agents; Brain Diseases; Herpes Simplex; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Hairless; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Vaccinia | 1989 |
Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication.
Topics: Adenine; Adenosine; Antimetabolites; Antiviral Agents; Cell Line; Cell Survival; DNA, Viral; Herpesvirus 4, Human; Organophosphonates; Organophosphorus Compounds; Virus Replication | 1987 |
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; HIV; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental | 1989 |
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro.
Topics: Adenine; African Swine Fever Virus; Amides; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Iridoviridae; Organophosphonates; Organophosphorus Compounds; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tubercidin; Vero Cells; Virus Replication; Zidovudine | 1987 |
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cell-Free System; Cloning, Molecular; Culture Techniques; Drug Resistance, Microbial; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; RNA-Directed DNA Polymerase | 1995 |
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.
Topics: Adenine; Animals; Antiviral Agents; Interferons; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Time Factors | 1994 |
High recombinagenic activities of three antiviral agents, adenine derivatives, in the Drosophila wing spot test.
Topics: Abnormalities, Drug-Induced; Adenine; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Larva; Male; Mitosis; Mutagenicity Tests; Mutagens; Organophosphonates; Recombination, Genetic; Wings, Animal | 1994 |
Efficacy of 9-(2-phosphonylmethoxyethyl)adenine treatment against chronic simian immunodeficiency virus infection in macaques.
Topics: Adenine; Animals; Antiviral Agents; Chronic Disease; DNA, Viral; Leukocytes, Mononuclear; Lymphocyte Subsets; Macaca fascicularis; Organophosphonates; Proviruses; RNA-Directed DNA Polymerase; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 1995 |
Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.
Topics: Adenine; Antiviral Agents; Biological Transport; Cell Membrane; Cells, Cultured; HeLa Cells; Humans; Organophosphonates; Structure-Activity Relationship | 1995 |
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
Topics: Adenine; Adenine Nucleotides; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation; Cell Division; Choriocarcinoma; HIV; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Organophosphonates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Foscarnet; Organophosphonates; Organophosphorus Compounds; Vero Cells | 1995 |
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Brain; Cytopathogenic Effect, Viral; Disease Models, Animal; Drug Evaluation, Preclinical; HIV Infections; Leukocytes, Mononuclear; Organophosphonates; Sheep; Visna; Visna-maedi virus | 1995 |
Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy)ethoxy]adenine.
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Female; Intestinal Absorption; Mice; Mice, Inbred BALB C; Organophosphonates; Prodrugs | 1995 |
Antitrypanosomal activity of phosphonylmethoxyalkylpurines.
Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African | 1994 |
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system.
Topics: Adenine; Animals; Cell Line; Cytopathogenic Effect, Viral; Dogs; Immunologic Factors; Influenza A virus; Kidney; Mice; Mice, Inbred C57BL; Organophosphonates; Orthomyxoviridae Infections | 1994 |
Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA).
Topics: Adenine; Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Cells, Cultured; Graft vs Host Reaction; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Organophosphonates | 1994 |
A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.
Topics: Adenine; Adenosine Kinase; Antiviral Agents; Biological Transport; Cell Line; Deoxycytidine Kinase; Drug Resistance; Humans; Organophosphonates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); T-Lymphocytes | 1995 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma; Female; Mice; Mice, Inbred C57BL; Organophosphonates; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sarcoma, Experimental; Tumor Cells, Cultured | 1993 |
Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adenine; Animals; Antiviral Agents; beta-Cyclodextrins; Biological Availability; Cyclodextrins; Macaca fascicularis; Male; Organophosphonates; Prodrugs; Propylene Glycols; Retroviridae; Suspensions | 1994 |
Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV-1; Humans; Molecular Structure; Organophosphonates; Organophosphorus Compounds; T-Lymphocytes; Zidovudine | 1994 |
Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Male; Organophosphonates; Prodrugs; Rats | 1994 |
Preexposure prophylaxis with 9-(2-phosphonylmethoxyethyl)adenine against simian immunodeficiency virus infection in macaques.
Topics: Adenine; Animals; Antibodies, Viral; Base Sequence; DNA Primers; DNA, Viral; Dose-Response Relationship, Drug; Leukocytes, Mononuclear; Macaca; Molecular Sequence Data; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets | 1994 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.
Topics: Adenine; Animals; Antineoplastic Agents; Leukemia, Experimental; Leukemia, Lymphoid; Male; Organophosphonates; Rats; Rats, Inbred Lew | 1993 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats.
Topics: Adenine; Animals; Antineoplastic Agents; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Leukemic Infiltration; Male; Organophosphonates; Rats; Rats, Sprague-Dawley | 1993 |
Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Chick Embryo; Cidofovir; Cytosine; Female; Fibroblasts; Humans; Lung; Male; Mitosis; Organophosphonates; Organophosphorus Compounds; Polydactyly; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1993 |
Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Body Fluid Compartments; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Macaca fascicularis; Male; Organophosphonates | 1994 |
Model of acute graft-vs-host-disease in adult (SHR x BN.lx)F1 rats and its inhibition by adenine analog.
Topics: Adenine; Animals; Bone Marrow Transplantation; Disease Models, Animal; Female; Graft vs Host Disease; Hybridization, Genetic; Immunosuppressive Agents; Male; Organophosphonates; Rats; Rats, Inbred BN; Rats, Inbred SHR; Transplantation, Homologous | 1993 |
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Extracellular Space; HIV-1; Humans; Kinetics; Lymphoid Tissue; Nucleosides; Organophosphonates; Prodrugs; Time Factors | 1993 |
Prevention of acute graft-versus-host disease in rats using 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Topics: Acute Disease; Adenine; Animals; Disease Models, Animal; Female; Graft vs Host Disease; Immunosuppressive Agents; Immunotherapy; Injections, Intraperitoneal; Organophosphonates; Rats; Rats, Inbred BN; Rats, Inbred SHR | 1993 |
Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process.
Topics: Adenine; Antiviral Agents; B-Lymphocytes; Cell Line; Dideoxynucleosides; Dideoxynucleotides; Esters; HIV-1; Humans; Organophosphonates; Oxidoreductases; Prodrugs; T-Lymphocytes; Thymine Nucleotides; Uridine Monophosphate; Zidovudine | 1993 |
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine | 1993 |
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Nucleus; Cidofovir; Cytosine; Herpesviridae; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Structure-Activity Relationship; Thymidine Kinase; Virus Replication | 1994 |
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; DNA, Viral; Ducks; Evaluation Studies as Topic; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Humans; Liver; Organophosphonates; Virus Replication | 1993 |
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
Topics: Adenine; Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Soman; Stereoisomerism; Structure-Activity Relationship; Virus Replication | 1996 |
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1995 |
Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells.
Topics: Adenine; Adenylate Kinase; Antiviral Agents; Biotransformation; Cell Line; Humans; Lymphocytes; Organophosphonates; Phosphorylation; Substrate Specificity; Sulfhydryl Reagents | 1995 |
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Deoxyadenine Nucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 1, Human; HIV; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Organophosphonates; Vero Cells | 1996 |
MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Didanosine; DNA, Viral; Guanine; HIV Infections; HIV-1; HIV-2; Humans; Male; Mice; Mice, SCID; Monocytes; Organophosphonates; Spleen; T-Lymphocytes; Zidovudine | 1996 |
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
Topics: Adenine; Antiviral Agents; HIV Reverse Transcriptase; HIV-1; Kinetics; Organophosphonates; Phosphates; Rauscher Virus; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zidovudine | 1996 |
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; In Vitro Techniques; Leukemia, Experimental; Mice; Mice, Inbred Strains; Mice, SCID; Moloney murine sarcoma virus; Organophosphonates; Prodrugs; Rats; Retroviridae; Retroviridae Infections; Sarcoma, Experimental; Tumor Virus Infections | 1996 |
Colorimetric assay system for screening antiviral compounds against hepatitis B virus.
Topics: Adenine; Antiviral Agents; Base Sequence; Colorimetry; DNA Primers; DNA, Viral; Drug Evaluation, Preclinical; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Molecular Sequence Data; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1996 |
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro.
Topics: Adenine; Antiviral Agents; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Oligonucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication | 1996 |
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Topics: Adenine; Amino Acid Sequence; Anti-HIV Agents; Cell Line; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Organophosphonates; Point Mutation; Serial Passage | 1996 |
Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.
Topics: Adenine; Antineoplastic Agents; Cell Differentiation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia, Erythroblastic, Acute; Nucleosides; Organophosphonates; Phenotype; Purines; Pyrimidines; Tritium; Tumor Cells, Cultured | 1996 |
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Topics: Adenine; Administration, Oral; Antiviral Agents; Biological Availability; Cell Line; Drug Stability; Herpesvirus 1, Human; Humans; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; Drug Carriers; Erythrocytes; Herpesvirus 1, Human; HIV-1; Humans; Macrophages; Organophosphonates; Vero Cells | 1997 |
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NM
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Fibroblasts; Guanine; Humans; Mice; Mice, Inbred C3H; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Sarcoma Viruses, Murine; Tenofovir | 1997 |
Early treatment with 9-(2-phosphonylmethoxyethyl)adenine reduces virus burdens for a prolonged period in SIV-infected rhesus macaques.
Topics: Adenine; Animals; Antiviral Agents; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Viral Load; Virus Replication | 1997 |
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Topics: Adenine; Animals; Antiviral Agents; Caco-2 Cells; Chromatography, High Pressure Liquid; Humans; Intestinal Absorption; Organophosphonates; Prodrugs; Swine | 1997 |
Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Organophosphonates; Prodrugs; Rats; Rats, Sprague-Dawley | 1997 |
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
Topics: Adenine; Antineoplastic Agents; Cell Line; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Simian virus 40; Tenofovir | 1997 |
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; CD4 Antigens; Cell Line; Cidofovir; Cytosine; Genetic Engineering; HeLa Cells; Herpesvirus 1, Human; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Phosphorylation; T-Lymphocytes; Virus Replication | 1997 |
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection.
Topics: Adenine; AIDS Vaccines; Animals; Antiviral Agents; Cells, Cultured; Humans; Kinetics; Lymphocytes; Macaca nemestrina; Models, Theoretical; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Time Factors; Viral Vaccines; Viremia; Virus Replication | 1997 |
Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses.
Topics: Adenine; Anti-HIV Agents; Drug Interactions; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Cells, Cultured | 1997 |
In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir).
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; HeLa Cells; Humans; Organophosphonates | 1997 |
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Topics: Adenine; Antiviral Agents; Caco-2 Cells; Chromatography, Ion Exchange; Esters; Humans; Organophosphonates; Prodrugs | 1998 |
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antiviral Agents; Choriocarcinoma; Drug Administration Schedule; Neoplasm Transplantation; Organophosphonates; Prodrugs; Rats; Rats, Inbred Strains; Tumor Cells, Cultured | 1998 |
Genotoxicity of purine acyclic nucleotide analogs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine | 1997 |
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.
Topics: Adenine; Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Choriocarcinoma; Methotrexate; Organophosphonates; Progesterone; Rats; Rats, Inbred Strains; Stereoisomerism | 1998 |
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Survival; Clone Cells; Female; Leukemia Virus, Murine; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Organophosphonates; Organophosphorus Compounds; Specific Pathogen-Free Organisms; Spleen; Tenofovir; Virus Replication; Zidovudine | 1998 |
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.
Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Neoplasm; Antigens, Surface; Antiviral Agents; Cell Differentiation; Cell Survival; Choriocarcinoma; Drug Therapy, Combination; Enzyme Induction; Growth Inhibitors; Kidney Neoplasms; Methotrexate; Organophosphonates; Organophosphorus Compounds; Progesterone; Rats; Rats, Inbred Strains; Rats, Wistar; Retroviridae; Tenofovir; Trophoblasts; Tumor Cells, Cultured | 1998 |
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine | 1998 |
Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.
Topics: Adenine; Amino Acid Sequence; Anti-HIV Agents; Baculoviridae; DNA-Directed DNA Polymerase; Drug Resistance; Hepatitis B virus; Humans; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; Recombinant Proteins | 1998 |
Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analogue.
Topics: Adenine; Animals; Antiviral Agents; Biomarkers; Depression, Chemical; DNA Probes; DNA, Viral; Ducks; Hepatitis B Virus, Duck; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Liver; Organophosphonates; Pancreas; RNA, Viral; Viral Proteins; Virus Replication | 1998 |
Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides.
Topics: Adenine; Anti-HIV Agents; Electrophoresis, Capillary; Organophosphonates; Ribonucleotides | 1998 |
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
Topics: Adenine; Animals; Antibodies; Antiviral Agents; Brain; Cell Count; Cells, Cultured; Central Nervous System; Leukocytes; Organophosphonates; RNA Virus Infections; Sheep; Visna-maedi virus | 1998 |
Impact of 9-(2-phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells.
Topics: Adenine; Animals; Antimetabolites, Antineoplastic; CDC2-CDC28 Kinases; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Deoxyribonucleotides; DNA, Neoplasm; Humans; Isotope Labeling; K562 Cells; Mice; Molecular Structure; Organophosphonates; Protein Biosynthesis; Protein Serine-Threonine Kinases; Ribonucleotides; RNA; RNA, Neoplasm; S Phase; Thymidine; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1999 |
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Drug Resistance, Multiple; Guanine; Hepatitis B virus; Lamivudine; Microbial Sensitivity Tests; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Zalcitabine | 1999 |
Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors.
Topics: Acyclovir; Adenine; Carcinoma, Hepatocellular; Drug Resistance, Microbial; Guanine; Hepatitis B virus; Humans; Lamivudine; Mutagenesis, Site-Directed; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Transfection; Tumor Cells, Cultured | 1999 |
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.
Topics: Adenine; Annexin A5; Apoptosis; Cell Cycle; Cell Differentiation; Cell Division; Cell Survival; Cyclin A; Cyclin B; Cyclin B1; Cyclin E; DNA Fragmentation; Flow Cytometry; Gene Expression; Growth Inhibitors; Humans; K562 Cells; Molecular Structure; Monocytes; Organophosphonates; Proto-Oncogene Proteins c-myc; RNA, Messenger; S Phase | 1999 |
9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*.
Topics: Adenine; Animals; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Replication; DNA-Directed DNA Polymerase; Organophosphonates; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1999 |
Hydroxyurea enhances the activities of didanosine, 9-[2-(phosphonylmethoxy)ethyl]adenine, and 9-[2-(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates.
Topics: Adenine; Anti-HIV Agents; Antineoplastic Agents; Didanosine; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Inhibitory Concentration 50; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 1999 |
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL5; Female; Fibrosis; Macrophages, Peritoneal; Nitric Oxide; Organ Size; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Inbred Lew; Spleen; Tenofovir | 1999 |
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
Topics: Adenine; Amino Acid Sequence; Animals; Anion Transport Proteins; Antiviral Agents; Base Sequence; Biological Transport; Carrier Proteins; Cidofovir; Cloning, Molecular; Cytosine; DNA, Complementary; Humans; Immunoblotting; Kidney; Molecular Sequence Data; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats | 1999 |
Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier.
Topics: Adenine; Animals; Antiviral Agents; Drug Carriers; Drug Delivery Systems; Humans; Lipoproteins, HDL; Lithocholic Acid; Liver; Organophosphonates; Prodrugs; Rats; Tritium | 1999 |
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Topics: Adenine; Anti-HIV Agents; Carrier Proteins; Cell Line; Drug Resistance, Microbial; Gene Amplification; Gene Dosage; Gene Expression; Genes, Dominant; HIV-1; Humans; Hybrid Cells; Inhibitory Concentration 50; Membrane Transport Proteins; Nucleosides; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; RNA, Messenger; T-Lymphocytes; Zidovudine | 1999 |
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Antiviral Agents; Brain; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Kinetics; Organophosphonates; Rats; Tenofovir | 1999 |
Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine; Antiviral Agents; Chemical Precipitation; Chromatography, Liquid; Drug Stability; Fluorescent Dyes; Humans; Indicators and Reagents; Mass Spectrometry; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Trichloroacetic Acid | 1999 |
Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Chromatography; Drug Carriers; Hepatitis B; Lipoproteins, HDL; Lithocholic Acid; Liver; Male; Organophosphonates; Prodrugs; Rats; Rats, Wistar; Tissue Distribution; Tritium | 2000 |
In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cells, Cultured; Drug Interactions; Drug Therapy, Combination; Ducks; Guanine; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Humans; Lamivudine; Liver; Organophosphonates; Virus Replication | 2000 |
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.
Topics: Adenine; Alanine; Animals; Anion Transport Proteins; Antiviral Agents; Biological Transport; Carrier Proteins; CHO Cells; Cidofovir; Cricetinae; Cytosine; Humans; Kidney; Organophosphate Poisoning; Organophosphonates; Organophosphorus Compounds; Probenecid | 2000 |
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture.
Topics: Acyclovir; Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Guanine; Hepatitis B virus; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Cells, Cultured | 2000 |
Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Dioxolanes; DNA-Directed DNA Polymerase; DNA, Viral; Guanine; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Purine Nucleosides; Tenofovir; Virus Replication | 2000 |
Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; Antiviral Agents; Lymph Nodes; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load | 2000 |
Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; DNA, Circular; DNA, Viral; Epidermal Growth Factor; Hepatitis B Virus, Woodchuck; Liver; Marmota; Organophosphonates; Virus Replication | 2000 |
Incidental treatment of hepatitis B virus infection in an AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2000 |
Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.
Topics: Adenine; Animals; Antiviral Agents; Herpesvirus 1, Human; Humans; Liver; Male; Organophosphonates; Prodrugs; Rats; Rats, Wistar; Tritium; Tumor Cells, Cultured | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Amino Acid Substitution; Antiviral Agents; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Herpesvirus 1, Human; Mutation; Nucleosides; Organophosphonates; Prodrugs; Protein Structure, Tertiary; Stereoisomerism; Substrate Specificity; Thymidine; Thymidine Kinase; Viral Proteins; Water | 2000 |
Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection.
Topics: Adenine; Animals; Disease Models, Animal; DNA, Viral; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2000 |
Mechanistic study on the cytostatic and tumor cell differentiation-inducing properties of 9-(2-phosphonylmethoxyethyl)adenine (PMEA, adefovir)-collected publications.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Hepatitis B; HIV Infections; Humans; Neoplasms; Organophosphonates; Rats; Tumor Cells, Cultured | 2000 |
Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA, Viral; Drug Resistance; Hepatitis B Virus, Duck; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Transcription, Genetic | 2001 |
[Current treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Anti-Inflammatory Agents; Antiviral Agents; DNA Replication; Famciclovir; Forecasting; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Prednisone; Prognosis; Reverse Transcriptase Inhibitors; Time Factors; Virus Replication | 2001 |
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC).
Topics: Acyclovir; Adenine; Amino Acid Sequence; Antiviral Agents; Cytidine Triphosphate; Deoxycytidine; Dideoxynucleotides; Drug Resistance, Microbial; Emtricitabine; Guanine; Hepatitis B virus; Humans; Lamivudine; Models, Molecular; Molecular Sequence Data; Organophosphonates; Protein Conformation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Homology, Amino Acid | 2001 |
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
Topics: Adenine; Alanine; Amides; Antiviral Agents; Drug Stability; Esterases; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphoric Acids; Prodrugs; Retroviridae; Structure-Activity Relationship; Tenofovir | 2001 |
CDC to revisit AZT, post-exposure guidelines. Centers for Disease Control and Prevention.
Topics: Adenine; Antiviral Agents; Blood-Borne Pathogens; Centers for Disease Control and Prevention, U.S.; Guidelines as Topic; Health Personnel; HIV Infections; Humans; Macaca; Needlestick Injuries; Occupational Exposure; Organophosphonates; Zidovudine | 1996 |
Update on other antivirals.
Topics: Adenine; Antiviral Agents; Didanosine; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Stavudine; Zalcitabine; Zidovudine | 1996 |
PMPA beats SIV again.
Topics: Adenine; Anemia; Animals; Antiviral Agents; Hemoglobins; Macaca; Organophosphonates; Phosphates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 1996 |
Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus.
Topics: Adenine; Antiviral Agents; Carbon Radioisotopes; Drug Delivery Systems; Erythrocytes; Herpesvirus 1, Human; HIV-1; Humans; Macrophages; Microbial Sensitivity Tests; Organophosphonates | 2001 |
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.
Topics: Adenine; Antiviral Agents; Binding Sites; Chelating Agents; Drug Stability; Hydrogen-Ion Concentration; Metals, Heavy; Organophosphonates; Organoplatinum Compounds; Polyamines | 2001 |
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion.
Topics: Acute Kidney Injury; Adenine; Adult; Antiviral Agents; Cytochrome-c Oxidase Deficiency; Dissection; DNA, Mitochondrial; Drug Therapy, Combination; Electron Transport Complex IV; HIV Infections; Humans; Immunoenzyme Techniques; Kidney Tubules, Proximal; Male; Micromanipulation; Mitochondria; Necrosis; Organophosphonates; Polymerase Chain Reaction; Succinate Dehydrogenase | 2001 |
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Dioxolanes; Drug Resistance, Microbial; Hepatitis B virus; Humans; Lamivudine; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Organophosphonates; Purine Nucleosides; Transfection; Tumor Cells, Cultured; Virus Replication | 2001 |
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus.
Topics: Adenine; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Delivery Systems; Hepatitis B virus; Humans; Lactose; Lipoproteins, HDL; Lithocholic Acid; Microbial Sensitivity Tests; Organophosphonates; Tumor Cells, Cultured; Virus Replication | 2001 |
Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2001 |
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Kidney Tubules, Proximal; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Agents; Xenobiotics | 2001 |
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Division; Cidofovir; Cytosine; Epithelial Cells; Growth Inhibitors; Herpesvirus 4, Human; Humans; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Xenograft Model Antitumor Assays | 2001 |
Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir.
Topics: Acute Disease; Adenine; Adult; Anti-HIV Agents; Drug Resistance, Viral; Graft Rejection; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Immunoglobulins, Intravenous; Immunohistochemistry; Lamivudine; Liver; Liver Transplantation; Male; Organophosphonates | 2001 |
Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro.
Topics: Adenine; Animals; Antiviral Agents; Disease Models, Animal; DNA, Circular; DNA, Viral; Ducks; Hepatitis B; Hepatitis B Virus, Duck; Hepatocytes; Organophosphonates | 2002 |
Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy.
Topics: Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Foscarnet; Herpes Genitalis; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Raman spectroscopy study of acid-base and structural properties of 9-[2-(phosphonomethoxy)ethyl]adenine in aqueous solutions.
Topics: Acids; Adenine; Crystallography, X-Ray; Hydrogen-Ion Concentration; Models, Chemical; Organophosphonates; Protein Conformation; Spectrum Analysis, Raman | 2002 |
Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Blood Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; DNA, Viral; Female; Humans; Injections, Intraperitoneal; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Organophosphonates; Polymerase Chain Reaction; Prodrugs; Retroviridae; Retroviridae Infections; Tumor Cells, Cultured | 2002 |
Adefovir (Hepsera) for chronic hepatitis B infection.
Topics: Adenine; Administration, Oral; Controlled Clinical Trials as Topic; Creatinine; Drug Resistance, Viral; Economics, Pharmaceutical; Fees, Pharmaceutical; Hepatitis B, Chronic; Humans; Kidney Diseases; Organophosphonates; Urine | 2002 |
Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro.
Topics: Adenine; Baculoviridae; Carcinoma, Hepatocellular; Drug Resistance, Viral; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; In Vitro Techniques; Lamivudine; Liver Neoplasms; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured; Virus Replication | 2003 |
Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.
Topics: Adenine; Antiviral Agents; DNA, Mitochondrial; Hepatitis B virus; Hepatitis B, Chronic; Hepatoblastoma; Humans; Mitochondria, Liver; Muscle, Skeletal; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Tumor Cells, Cultured | 2003 |
Antiviral effect of adefovir in combination with a DNA vaccine in the duck hepatitis B virus infection model.
Topics: Adenine; Animals; Antibody Formation; Antiviral Agents; Ducks; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Immunization; Liver; Organophosphonates; Vaccines, DNA; Viremia; Virus Replication | 2003 |
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antiviral Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Membrane; Colforsin; Coloring Agents; Cyclic AMP; Cyclic GMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Genetic Vectors; Growth Inhibitors; Immunoblotting; Inhibitory Concentration 50; Insecta; Models, Biological; Nitrosamines; Nucleotides; Organophosphonates; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Zalcitabine | 2003 |
Manufacturer end adefovir development.
Topics: Adenine; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2000 |
[Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry].
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, Liquid; Macaca mulatta; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2003 |
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Poxviridae Infections; Prodrugs; Skin; Tenofovir; Virus Replication | 2003 |
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.
Topics: Adenine; Animals; Capsid; Combined Modality Therapy; Disease Models, Animal; Gene Expression Regulation, Viral; Genetic Therapy; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Lamivudine; Liver; Male; Mice; Mice, Inbred Strains; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Small Interfering; Specific Pathogen-Free Organisms; Virus Replication | 2003 |
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
Topics: Adenine; Antiviral Agents; Badnavirus; Musa; Organophosphonates; Organophosphorus Compounds; Plant Diseases; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2003 |
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Inhibitory Concentration 50; Interleukin-10; Interleukin-2; Lymphocytes; Mice; Mice, Inbred C57BL; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Tenofovir | 2003 |
Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure.
Topics: Acute Disease; Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Graft Survival; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Hospital Mortality; Humans; Liver Failure; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Retrospective Studies; Survival Analysis | 2003 |
Management of chronic hepatitis B in an HIV-positive patient with 3TC-resistant hepatitis B virus.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient.
Topics: Adenine; Amino Acid Sequence; Combined Modality Therapy; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Inhibitors | 2003 |
Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes.
Topics: Adenine; Animals; Antiviral Agents; DNA, Circular; DNA, Viral; Drug Therapy, Combination; Hepatitis B Antibodies; Hepatitis B virus; Hepatocytes; Lamivudine; Organophosphonates; Tupaia; Virus Replication | 2003 |
In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector.
Topics: Adenine; Antiviral Agents; Cell Line; Cloning, Molecular; DNA, Viral; Drug Resistance, Viral; Genetic Vectors; Genome, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Virus Replication | 2004 |
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Forecasting; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
[Adefovir].
Topics: Adenine; Antiviral Agents; Drug Monitoring; Drug Prescriptions; Hepatitis B, Chronic; Humans; Organophosphonates; Patient Education as Topic; Patient Selection | 2003 |
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Humans; Microglia; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats; Rats, Wistar; RNA, Messenger; Tritium | 2004 |
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antigens, Bacterial; Antiviral Agents; Bacterial Toxins; Binding Sites; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Exotoxins; Hepatitis B, Chronic; Kinetics; Models, Molecular; Organophosphonates; Protein Conformation; Recombinant Proteins; Spodoptera; Transfection | 2004 |
Antiretroviral therapy and HIV/hepatitis B virus coinfection.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Rearrangement process occurring in the fragmentation of adefovir derivatives.
Topics: Adenine; Antiviral Agents; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2004 |
[Viral hepatitis B/C and HIV. Therapy of double infections].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis C; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Treatment Outcome | 2003 |
Ultra sensitive method for the determination of 9-(2-phosphonylmethoxyethyl)adenine in human serum by liquid chromatography-tandem mass spectrometry.
Topics: Adenine; Antiviral Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity | 2004 |
Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.
Topics: Adenine; Animals; Catalysis; Cytarabine; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Drug Design; Hepatocytes; Humans; Liver; Male; Organophosphonates; Phosphates; Phosphotransferases; Prodrugs; Rats; Stereoisomerism; Time Factors; Vidarabine | 2004 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins | 2004 |
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Cell Line; DNA-Directed DNA Polymerase; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Transfection; Virus Replication | 2004 |
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Models, Molecular; Organophosphonates | 2004 |
Prevention of hepatitis B virus reinfection after orthotopic liver transplantation.
Topics: Adenine; Adult; Combined Modality Therapy; Female; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Reverse Transcriptase Inhibitors; Secondary Prevention | 2004 |
Liver-targeted drug delivery using HepDirect prodrugs.
Topics: Acetaminophen; Adenine; Analgesics, Non-Narcotic; Animals; Biotransformation; Bone Marrow; Cell Separation; Cytarabine; Drug Delivery Systems; Glutathione; Hepatocytes; In Vitro Techniques; Inactivation, Metabolic; Liver; Male; Mice; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Tissue Distribution | 2005 |
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.
Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; Biological Transport; Catalysis; Cations; Cell Line; Cell Membrane; Chelating Agents; Cobalt; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Fluorides; Humans; Hydrolysis; Insecta; Kinetics; Magnesium; Manganese; Methotrexate; Models, Biological; Multidrug Resistance-Associated Proteins; Nucleotides; Organophosphonates; Protein Binding; Substrate Specificity; Vanadates; Zidovudine | 2004 |
Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro.
Topics: Adenine; Antiviral Agents; Blotting, Southern; Cell Line; Cell Survival; Drug Combinations; Drug Synergism; Hepatitis B virus; Humans; Nucleosides; Organophosphonates | 2004 |
Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells.
Topics: Adenine; Animals; Antiviral Agents; Biological Transport; Cells, Cultured; Deoxyadenine Nucleotides; Half-Life; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Phosphorylation | 2004 |
[Active prevention and treatment of superinfection with HBV, HCV and HIV].
Topics: Adenine; Antiretroviral Therapy, Highly Active; Hepatitis B, Chronic; Hepatitis C, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates | 2004 |
[An attempt to approach an optional therapeutic regimen for chronic hepatitis B].
Topics: Adenine; Animals; Antiviral Agents; Combined Modality Therapy; Genetic Therapy; Hepatitis B Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins | 2004 |
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antiviral Agents; Hepadnaviridae; Herpesviridae; Mice; Models, Chemical; Moloney murine sarcoma virus; Nucleosides; Organophosphonates; Poxviridae; Pyrimidine Nucleosides; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Chronic Disease; DNA-Directed DNA Polymerase; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2004 |
Adefovir treatment in posttransplant hepatitis B virus infection resistant to lamivudine plus hepatitis B virus immunoglobulin.
Topics: Adenine; Adult; Antibodies, Viral; Antiviral Agents; Drug Resistance; Female; Hepatitis B; Hepatitis B Antibodies; Humans; Lamivudine; Living Donors; Male; Middle Aged; Organophosphonates; Recurrence | 2004 |
[Determination of adefovir dipivoxil and its degradation products by reversed-phase high performance liquid chromatography].
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Indicators and Reagents; Organophosphonates | 2004 |
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Nucleosides; Organophosphonates; Structure-Activity Relationship | 2005 |
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
Topics: Adenine; Adult; Animals; Anions; Antineoplastic Agents; DNA, Complementary; Genetic Variation; Genotype; Haplotypes; Heterozygote; Humans; Kidney; Kinetics; Male; Methotrexate; Models, Chemical; Models, Genetic; Mycotoxins; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters; Organophosphonates; p-Aminohippuric Acid; Pedigree; Pharmacogenetics; Polymorphism, Genetic; Protein Structure, Secondary; RNA, Complementary; Xenobiotics; Xenopus laevis | 2005 |
Summaries for patients. Antiviral regimens for chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Decision Support Techniques; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver; Markov Chains; Organophosphonates; Recombinant Proteins; Salvage Therapy; Sensitivity and Specificity; Transaminases | 2005 |
Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Decision Support Techniques; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver; Markov Chains; Organophosphonates; Recombinant Proteins; Salvage Therapy; Sensitivity and Specificity; Transaminases | 2005 |
Assessing the benefits and costs of new therapies for hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B, Chronic; Humans; Organophosphonates | 2005 |
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA; Genetic Variation; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transport Protein 1; Organophosphonates; p-Aminohippuric Acid; Polymorphism, Single Nucleotide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Complementary; Tenofovir; Xenopus laevis | 2005 |
Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Viral; Genome, Viral; Hepatitis B virus; Humans; Lamivudine; Mutation; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Technology, Pharmaceutical; Virus Replication | 2005 |
Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Waiting Lists | 2005 |
Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Failure; Liver Neoplasms; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Retrospective Studies; Survival Analysis; Treatment Outcome | 2005 |
Reactivation of viral replication after replacement of tenofovir by adefovir.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure; Treatment Outcome; Virus Activation | 2005 |
Viral kinetics in patients with lamivudine-resistant hepatitis B during adefovir-lamivudine combination therapy.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Models, Theoretical; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Virus Replication | 2005 |
The risk of adefovir monotherapy in human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Organophosphonates; Treatment Outcome | 2005 |
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Ganciclovir; Guanine; Humans; Mice; Models, Molecular; Molecular Sequence Data; Muromegalovirus; Mutation; Organophosphonates; Protein Kinases; Sequence Alignment; Valacyclovir; Valine; Virus Replication | 2005 |
Chronic hepatitis B--treatment with nucleoside analogues.
Topics: Adenine; Drug Resistance; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors | 2005 |
Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.
Topics: Adenine; Administration, Oral; Adult; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Metabolic Clearance Rate; Organophosphonates; Pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Liver Failure; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2005 |
[Clinical outcomes after discontinuation of Lamivudine in chronic hepatitis B patients with Lamivudine resistant HBV mutant].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2005 |
Resistance to adefovir: a new challenge in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2005 |
Risk of selecting K65R in antiretroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir.
Topics: Adenine; Antiviral Agents; DNA, Viral; Genes, Viral; Genotype; Hepatitis B e Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral | 2005 |
Cost-effectiveness in hepatitis B.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins | 2005 |
Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatment.
Topics: Adenine; Adult; Alanine Transaminase; DNA, Viral; Drug Resistance, Viral; Female; Heart Diseases; Heart Transplantation; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Organophosphonates; Postoperative Period; Promoter Regions, Genetic; Reverse Transcriptase Inhibitors; Virus Activation | 2005 |
Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H.
Topics: Adenine; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Humans; Lamivudine; Leukemia, Lymphocytic, Chronic, B-Cell; Organophosphonates; Recurrence; Treatment Outcome | 2006 |
Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies | 2005 |
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.
Topics: Acetylcholinesterase; Adenine; Anti-HIV Agents; Benzyl Alcohols; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; HIV-1; HIV-2; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 2005 |
Virologic response and resistance to adefovir in patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies; Treatment Outcome | 2006 |
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes.
Topics: Adenine; Animals; Antiviral Agents; Catechols; Cytochrome P-450 Enzyme System; Female; Microsomes, Liver; Nitrophenols; Organophosphonates; Rats; Rats, Inbred Lew; RNA, Messenger | 2006 |
Adefovir therapy for lamivudine escape and hepatitis B virus reactivation after reduced intensity conditioning allogeneic stem cell transplantation.
Topics: Adenine; Adult; Antineoplastic Agents; Combined Modality Therapy; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Leukemia, Myeloid, Acute; Organophosphonates; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome; Viral Load; Virus Activation | 2006 |
Chronic hepatitis B: a critical appraisal of current approaches to therapy.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biopsy; Clinical Competence; Disease Progression; DNA, Viral; Drug Therapy, Combination; Endpoint Determination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver; Organophosphonates; Patient Selection; Polyethylene Glycols; Recombinant Proteins; Societies, Medical; Virus Replication | 2006 |
Combination therapy for chronic hepatitis B: a one-two knockout punch, or a swing and a miss?
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2006 |
Replacement of tenofovir with adefovir may result in reactivation of hepatitis B virus replication.
Topics: Adenine; Antiviral Agents; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2006 |
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance, Viral; Ducks; Filaggrin Proteins; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatocytes; Humans; Lamivudine; Liver Neoplasms; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication | 2006 |
Sensitive line probe assay that simultaneously detects mutations conveying resistance to lamivudine and adefovir.
Topics: Adenine; Antiviral Agents; Base Sequence; DNA Probes; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; In Vitro Techniques; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Virology | 2006 |
First report of genotypic resistance to adefovir in chronic HBV in the Republic of Ireland.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Ireland; Male; Mutation; Organophosphonates | 2006 |
Antiviral options for the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2006 |
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Female; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors | 2005 |
Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Bilirubin; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Serum Albumin; Statistics, Nonparametric | 2006 |
Prophylactic strategies for hepatitis B patients undergoing liver transplant: a cost-effectiveness analysis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Health Care Costs; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Markov Chains; Middle Aged; Organophosphonates; Recurrence | 2006 |
Variant of hepatitis B virus with primary resistance to adefovir.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Viremia | 2006 |
[Reactivation of hepatitis B treated with adefovir after infliximab administration].
Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Hepatitis B; Humans; Immunosuppressive Agents; Infliximab; Male; Middle Aged; Organophosphonates; Psoriasis; Recurrence | 2006 |
Tubular transporters and clearance of adefovir.
Topics: Adenine; Animals; ATP-Binding Cassette Transporters; Biological Transport; Chromatography, High Pressure Liquid; Coproporphyrins; Immunosuppressive Agents; Kidney Tubules; Male; Metabolic Clearance Rate; Models, Biological; Mutation; Organic Anion Transport Protein 1; Organophosphonates; Probenecid; Rats; Rats, Wistar; Time Factors; Uricosuric Agents | 2006 |
Development and validation of a sensitive LC-MS/MS method for the determination of adefovir in human serum and urine.
Topics: Adenine; Adult; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Male; Mass Spectrometry; Organophosphonates; Sensitivity and Specificity | 2006 |
Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus.
Topics: Adenine; Antiviral Agents; Cell Line; Cells, Cultured; Drug Resistance, Viral; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Phosphorylation; Tenofovir | 2006 |
Hepatitis B virus with primary resistance to adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Viral Load | 2006 |
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.
Topics: Adenine; Adult; Disease Progression; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Gene Products, pol; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Virus Replication | 2006 |
[Tubular transporters OAT1 and MRP2 and clearance of adefovir].
Topics: Adenine; Animals; Antiviral Agents; Kidney; Male; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Probenecid; Rats; Rats, Wistar; Uricosuric Agents | 2005 |
Favorable outcome of liver transplantation despite a high hepatitis B virus replication: beyond the limits?
Topics: Adenine; Antiviral Agents; Contraindications; Hepatitis B; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Treatment Outcome; Virus Replication | 2006 |
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.
Topics: Adenine; Animals; Antibodies, Monoclonal; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats | 2006 |
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; DNA, Circular; DNA, Viral; Drug Carriers; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Pilot Projects; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Treatment Outcome | 2006 |
Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
Topics: Adenine; Amino Acid Motifs; Animals; Antiviral Agents; Blotting, Southern; Cloning, Molecular; DNA, Viral; Drug Resistance, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Mice; Mutation; Organophosphonates; Plasmids; Polymorphism, Restriction Fragment Length; RNA, Viral; Transfection; Virus Replication | 2006 |
Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antigens, CD; Antiviral Agents; Cytokines; Dendritic Cells; DNA, Viral; Female; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Middle Aged; Myeloid Cells; Organophosphonates; Viral Load | 2006 |
Nonresponse to adefovir: host or virus dependent?
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B; Hepatitis B virus; Humans; Organophosphonates; RNA, Viral; Treatment Failure; Viremia | 2006 |
Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.
Topics: Adenine; Adult; Antiviral Agents; Biological Evolution; Cells, Cultured; Drug Resistance, Multiple; Drug Therapy, Combination; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Virus Replication | 2006 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses | 2007 |
Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity.
Topics: Adenine; Antiviral Agents; Half-Life; Hepatitis B virus; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Structure-Activity Relationship | 2007 |
A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient.
Topics: Adenine; Adult; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS.
Topics: Adenine; Cell Line, Tumor; Chromatography, Liquid; Deoxyadenine Nucleotides; Humans; Immunosuppressive Agents; Organophosphonates; Phosphorylation; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.
Topics: Adenine; Adenosine Triphosphate; Animals; Antiviral Agents; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Kidney; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Osmosis; Renal Insufficiency; Tenofovir; Tissue Distribution | 2007 |
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mice; Moloney murine sarcoma virus; Organophosphonates; Pyrimidines; Retroviridae Infections; Sarcoma, Experimental; Structure-Activity Relationship; Tenofovir; Tumor Virus Infections | 2007 |
Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations.
Topics: Adenine; Amino Acid Motifs; Aspartic Acid; Cryoglobulinemia; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Methionine; Middle Aged; Mutation; Organophosphonates; Recurrence; Tyrosine; Vasculitis | 2006 |
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Topics: Adenine; Bacteria; Cell Membrane; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Liver; Metabolic Detoxication, Phase I; Models, Biological; NADPH-Ferrihemoprotein Reductase; Organophosphonates; Oxygenases; Research Design; Tenofovir; Transformation, Bacterial | 2006 |
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Organophosphonates; Prodrugs; Tenofovir | 2006 |
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage.
Topics: Adenine; Animals; Bone Marrow; Brain; Drug Hypersensitivity; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multidrug Resistance-Associated Proteins; Organophosphonates; Spleen; Thymus Gland | 2007 |
COBAS AmpliPrep-COBAS TaqMan hepatitis B virus (HBV) test: a novel automated real-time PCR assay for quantification of HBV DNA in plasma.
Topics: Adenine; Antiviral Agents; Automation; Biopsy; DNA, Viral; Drug Resistance, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Nucleic Acid Amplification Techniques; Organophosphonates; Polymerase Chain Reaction; Sensitivity and Specificity; Taq Polymerase; Viremia | 2007 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: when and how?
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Salvage Therapy | 2007 |
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Epithelial Cells; Foscarnet; Ganciclovir; Herpesvirus 1, Equid; Horses; Lung; Organophosphonates | 2007 |
Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Hepatitis B virus; Humans; Lamivudine; Male; Mutation; Organophosphonates; Selection, Genetic | 2006 |
Hepatitis B virus reactivation in a case of Waldenstrom's macroglobulinemia treated with chemotherapy and rituximab despite adefovir prophylaxis.
Topics: Adenine; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Female; Hepatitis B virus; Humans; Immunotherapy; Organophosphonates; Rituximab; Waldenstrom Macroglobulinemia | 2007 |
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cowpox; Cytomegalovirus Infections; Cytosine; Herpes Simplex; HIV-1; Humans; In Vitro Techniques; Molecular Structure; Organophosphonates; Sensitivity and Specificity; Vaccinia | 2007 |
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Humans; Kidney; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Probenecid; Tenofovir; Transfection | 2007 |
Tailoring antiviral therapy in chronic hepatitis B patients with lamivudine resistance.
Topics: Adenine; Contraindications; Dose-Response Relationship, Drug; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2007 |
HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA).
Topics: Adenine; Administration, Cutaneous; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; In Vitro Techniques; Organophosphonates; Reproducibility of Results; Skin; Skin Absorption; Spectrophotometry, Ultraviolet; Swine | 2007 |
Combination therapy in liver transplant recipients with hepatitis B virus without hepatitis B immune globulin.
Topics: Adenine; Adult; Aged; Antibodies, Viral; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Immunization, Passive; Immunoglobulins; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Secondary Prevention; Treatment Outcome | 2007 |
Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma.
Topics: Adenine; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease Progression; Drug Resistance, Viral; Follow-Up Studies; Hepatectomy; Hepatitis B, Chronic; Humans; Immunohistochemistry; Lamivudine; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2007 |
Characteristics of patients with chronic hepatitis-B virus infection in an urban hospital.
Topics: Adenine; Adolescent; Adult; Black or African American; Contraindications; Female; Hepatitis B, Chronic; Hispanic or Latino; Hospitals, Urban; Humans; Insurance Coverage; Interferons; Lamivudine; Liver Cirrhosis; Male; Mass Screening; Middle Aged; New York City; Organophosphonates; Patient Compliance; Pilot Projects; Refusal to Treat; Risk Factors; Urban Health; Utilization Review | 2007 |
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Catalysis; Cell Line; Dose-Response Relationship, Drug; Endogenous Retroviruses; HIV-1; Humans; Kidney; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Stavudine; Swine; Swine, Miniature; Tenofovir; Virus Replication; Zidovudine | 2007 |
Optimal duration of therapy in HBV-related cirrhosis.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Health Planning Guidelines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2007 |
Recommendations for the treatment of chronic hepatitis B infection in children.
Topics: Adenine; Antiviral Agents; Child; Child, Preschool; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Male; Organophosphonates; Pakistan; Practice Guidelines as Topic | 2007 |
Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Gene Dosage; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Retrospective Studies; Reverse Transcriptase Inhibitors; Sex Factors; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2007 |
Does pre-treatment with lamivudine prime for adefovir resistance of hepatitis B virus infection?
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2007 |
Emergence of hepatitis B virus quasispecies with lower susceptibility to nucleos(t)ide analogues during lamivudine treatment.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Viremia | 2007 |
[An economic evaluation of different treatments for HBeAg-positive chronic hepatitis B in China].
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Quality-Adjusted Life Years; Treatment Outcome | 2007 |
Pre- and post-treatment predictors of the early achievement of HBeAg loss in lamivudine-resistant patients receiving adefovir therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Predictive Value of Tests; Reverse Transcriptase Inhibitors | 2007 |
In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.
Topics: Adenine; Adenosine Triphosphate; Boron Compounds; Catalysis; DNA-Directed RNA Polymerases; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Organophosphonates; Plasmids; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Delivery Systems; Hepatitis B, Chronic; Humans; Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Structure-Activity Relationship | 2007 |
[A case of chronic hepatitis B with primary adefovir resistance].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Organophosphonates | 2007 |
Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Female; Guideline Adherence; Health Care Surveys; Hepatitis B Vaccines; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tenofovir; United States | 2007 |
Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2007 |
Adefovir for lamivudine resistant HBV: more than meets the eye.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation; Organophosphonates | 2007 |
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Disease Models, Animal; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Exodeoxyribonucleases; Foscarnet; Genotype; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Models, Molecular; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Phenotype; Protein Binding; Protein Conformation; Vero Cells; Viral Proteins; Virulence | 2007 |
Redetection of HBV lamivudine-resistant mutations in a patient under entecavir therapy, who had been treated sequentially with nucleos(t)ide analogues.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2007 |
[New German and American guidelines for therapy of hepatitis B. Discrepancies and similarities].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biopsy; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Germany; Guanine; Hepatitis B; Humans; Lamivudine; Liver; Liver Cirrhosis; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Telbivudine; Thymidine; United States | 2007 |
[Effect of initial virologic response to adefovir on the development of resistance to adefovir in lamivudine-resistant chronic hepatitis B].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Retrospective Studies | 2007 |
[Recent therapies for hepatitis B (discussion)].
Topics: Adenine; Antiviral Agents; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2007 |
Successful treatment of an entecavir-resistant hepatitis B virus variant.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Viral Load | 2007 |
[Adefovir in reactivation of chemotherapy-induced hepatitis B in an anti-Hbc-positive patient].
Topics: Adenine; Aged; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bleomycin; Dacarbazine; Doxorubicin; Fatal Outcome; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphoma, Non-Hodgkin; Organophosphonates; Prion Diseases; Vinblastine; Virus Activation | 2007 |
Prophylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 years.
Topics: Adenine; Adult; Antiviral Agents; Dose-Response Relationship, Drug; Female; Hepatitis B; Hepatitis B e Antigens; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies; Secondary Prevention; Virginia | 2008 |
Hepatitis B: explosion of new knowledge.
Topics: Adenine; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Tolerance; Lamivudine; Organophosphonates | 2007 |
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.
Topics: Adenine; Administration, Oral; Animals; Biological Availability; Dogs; Hepatocytes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution | 2008 |
Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Viral Load; Virus Replication | 2008 |
Evaluation of initial virological response to adefovir and development of adefovir-resistant mutations in patients with chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Treatment Outcome; Viral Load | 2008 |
[Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length | 2008 |
Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers.
Topics: Adenine; Administration, Cutaneous; Antiviral Agents; Chromatography, High Pressure Liquid; Drug Delivery Systems; Excipients; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Organophosphonates; Permeability; Skin Absorption; Solvents | 2008 |
Anti-BK virus activity of nucleoside analogs.
Topics: Adenine; BK Virus; Esters; Fatty Acids; Humans; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Virus Replication | 2008 |
6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.
Topics: Adenine; Animals; Base Sequence; DNA Primers; Green Fluorescent Proteins; Humans; Mercaptopurine; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphonates; Recombinant Fusion Proteins; Xenopus laevis | 2008 |
Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2008 |
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure.
Topics: Adenine; Amino Acid Sequence; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Treatment Failure | 2008 |
Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding.
Topics: Adenine; Antiviral Agents; Aphidicolin; Binding Sites; Cell Division; DNA Polymerase I; Enzyme Inhibitors; Humans; Keratinocytes; Ligands; Models, Biological; Models, Molecular; Organophosphonates; Protein Conformation; Reverse Transcriptase Inhibitors | 2008 |
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
Topics: Adenine; Antiviral Agents; Base Sequence; California; Cell Line; Ethnicity; Haplotypes; Humans; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Sequence Alignment; Sequence Analysis, DNA; White People; Zidovudine | 2008 |
Antibody to hepatitis B surface antigen trough levels and half-lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Injections, Intramuscular; Injections, Intravenous; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence | 2008 |
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.
Topics: Adenine; Anti-HIV Agents; Binding Sites; Cidofovir; Cytosine; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Organophosphonates; Protein Conformation; Tenofovir | 2008 |
Economic evaluation of chronic hepatitis B treatments in Taiwan.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Taiwan; Time Factors | 2008 |
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
Topics: Adenine; Adenosine Triphosphate; Adenylate Kinase; Binding Sites; Boranes; Catalytic Domain; Cloning, Molecular; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Models, Molecular; Nucleotides; Organophosphonates; Phosphorylation; Recombinant Proteins; Tenofovir | 2008 |
Viral persistence after liver transplantation for hepatitis B virus: a cross-sectional study.
Topics: Adenine; Adult; Aged; Cross-Sectional Studies; DNA, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2008 |
Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Mutation; Organophosphonates; Risk Factors; Treatment Outcome; Virus Replication | 2008 |
Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy.
Topics: Adenine; Antiviral Agents; Automation; DNA, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Polymerase Chain Reaction; Taq Polymerase | 2008 |
Hepatitis B virus genotype A2 harbours an L217R polymorphism which may account for a lower response to adefovir.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Mutation, Missense; Organophosphonates | 2008 |
[Acute hepatitis B: is antiviral therapy indicated? Two case reports].
Topics: Acute Disease; Adenine; Adult; Algorithms; Antiviral Agents; Bilirubin; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Liver; Middle Aged; Organophosphonates; Prothrombin Time; Transaminases; Treatment Failure; Treatment Outcome | 2008 |
Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.
Topics: Adenine; Antiviral Agents; Biological Transport; Cell Membrane; Down-Regulation; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Immunosuppressive Agents; Kidney; Mercaptopurine; Multidrug Resistance-Associated Proteins; Organophosphonates; Phosphoproteins; Protein Transport; Recombinant Fusion Proteins; RNA, Small Interfering; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection | 2008 |
Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Viral; Genetic Vectors; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleic Acid Amplification Techniques; Organophosphonates; Plasmids; Replicon; Transfection; Virus Replication | 2008 |
Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant.
Topics: Adenine; Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Drug Resistance, Multiple, Viral; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Gene Products, pol; Guanine; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunodominant Epitopes; Lamivudine; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Transfection | 2008 |
[Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients].
Topics: Adenine; Antiviral Agents; Drug Approval; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Continuous single motor unit electromyographic activity in adefovir associated myopathy.
Topics: Adenine; Antiviral Agents; Chronic Disease; Creatine Kinase; Electromyography; Hepatitis B; Humans; Male; Middle Aged; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Diseases; Neuromuscular Junction; Organophosphonates; Withholding Treatment | 2008 |
What is the optimum dose of adefovir in the treatment of chronic hepatitis B infection?
Topics: Adenine; Adult; Antiviral Agents; Dose-Response Relationship, Drug; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Treatment Outcome | 2008 |
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species.
Topics: Adenine; Administration, Cutaneous; Animals; Antiviral Agents; Caproates; Chemistry, Pharmaceutical; Diffusion Chambers, Culture; Dimethylamines; Dodecanol; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Methylamines; Organophosphonates; Permeability; Pharmaceutical Vehicles; Skin; Skin Absorption; Species Specificity; Swine | 2008 |
Entecavir therapy for adefovir-resistant hepatitis B virus infection in kidney and liver allograft recipients.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Kidney Transplantation; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Organophosphonates; Pilot Projects; Prothrombin Time | 2008 |
Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy?
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Genetic Variation; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2008 |
[YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy].
Topics: Adenine; Amino Acid Motifs; Anti-HIV Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2008 |
Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases.
Topics: Acid Phosphatase; Adenine; Aluminum Compounds; Aniline Compounds; Beryllium; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fluorides; Hydrogen Bonding; Multigene Family; Organophosphonates; Organophosphorus Compounds; Protein Structure, Secondary; Substrate Specificity | 2008 |
Serum HBsAg changes in HBeAg positive chronic hepatitis B patients with continuous viral load reductions during treatment with adefovir or peg-interferon-alpha-2a.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Viral Load | 2009 |
Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers.
Topics: Adenine; Adult; Antiviral Agents; Carrier State; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Male; Organophosphonates; Virus Activation | 2008 |
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient.
Topics: Adenine; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; Tenofovir | 2008 |
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.
Topics: Adenine; Administration, Cutaneous; Alanine; Animals; Caproates; Chemistry, Pharmaceutical; Dimethylamines; Dodecanol; Drug Carriers; Drug Compounding; Drug Stability; Electric Impedance; Esterases; Halogenation; Hydrocortisone; Hydrolysis; Indomethacin; Isomerism; Methylamines; Molecular Structure; Organophosphonates; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline; Time Factors | 2009 |
Sensitivity and accuracy of an updated line probe assay (HBV DR v.3) in detecting mutations associated with hepatitis B antiviral resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA Probes; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Sensitivity and Specificity | 2009 |
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2009 |
Assessment of selective real-time PCR for quantitation of lamivudine and adefovir hepatitis B virus-resistant strains and comparison with direct sequencing and line probe assays.
Topics: Adenine; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Plasmids; Polymerase Chain Reaction; Sensitivity and Specificity | 2009 |
[Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B].
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2008 |
Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study.
Topics: Adenine; Adult; Carcinoma, Hepatocellular; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2009 |
Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Viral Load | 2009 |
Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Serum; Viral Load | 2009 |
On-treatment monitoring of adefovir therapy in chronic hepatitis B: virologic response can be assessed at 24 weeks.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Treatment Outcome; Viral Load | 2009 |
Early development of clevudine resistance during clevudine therapy in a patient with chronic hepatitis B who received prior lamivudine therapy.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA | 2009 |
Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response.
Topics: Adenine; Antiviral Agents; Biomarkers; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Models, Molecular; Organophosphonates; Predictive Value of Tests; Retrospective Studies; RNA-Directed DNA Polymerase | 2008 |
Emergence of adefovir-resistant mutants after reversion to YMDD wild-type in lamivudine-resistant patients receiving adefovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymorphism, Restriction Fragment Length; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Treatment Outcome; Viral Load | 2009 |
Gene induction for the treatment of methylmalonic aciduria.
Topics: Adenine; Cisplatin; Drug Evaluation, Preclinical; Gene Expression Regulation; Green Fluorescent Proteins; HeLa Cells; Humans; Metabolism, Inborn Errors; Methylmalonyl-CoA Mutase; Organophosphonates; RNA, Messenger; Zidovudine | 2009 |
Renal side effects of adefovir in hepatitis B virus-(HBV) positive kidney allograft recipients.
Topics: Acid-Base Equilibrium; Adenine; Aged; Antiviral Agents; Cohort Studies; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2009 |
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Genetic Variation; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Proteins | 2009 |
Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; RNA, Viral; Treatment Outcome; Viral Load; Young Adult | 2009 |
Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2009 |
[Atazanavir-induced nephrolithiasis].
Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Lopinavir; Male; Nephrolithiasis; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Tenofovir | 2009 |
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.
Topics: Adenine; Antiviral Agents; Base Sequence; DNA Primers; DNA, Viral; Drug Resistance, Viral; Genetic Variation; Genotype; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2009 |
Decision analysis model for hepatitis B prophylaxis one year after liver transplantation.
Topics: Adenine; Administration, Oral; Antiviral Agents; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Health Care Costs; Hepatitis B, Chronic; Humans; Immunoglobulins; Injections, Intramuscular; Lamivudine; Liver Transplantation; Markov Chains; Models, Economic; Organophosphonates; Retrospective Studies; Salvage Therapy; Secondary Prevention; Tenofovir; Time Factors; Treatment Failure; Treatment Outcome | 2009 |
Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy.
Topics: Adenine; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Antiviral Agents; Drug Therapy, Combination; Etanercept; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Immunoglobulin G; Infliximab; Lamivudine; Male; Methotrexate; Organophosphonates; Receptors, Tumor Necrosis Factor; Spondylarthropathies; Treatment Outcome; Tumor Necrosis Factor-alpha; Viral Load; Virus Activation | 2009 |
[Analysis of the cost-effectiveness of antiviral therapies in chronic hepatitis B patients in Korea].
Topics: Adenine; Antiviral Agents; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Korea; Lamivudine; Models, Statistical; Organophosphonates; Quality of Life; Severity of Illness Index | 2009 |
Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues.
Topics: Adenine; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2009 |
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Drug Resistance, Viral; Esters; Female; Hepatitis B virus; Humans; Lamivudine; Male; Mice; Mice, Transgenic; Organophosphonates; Virus Replication | 2009 |
Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C, Chronic; Hispanic or Latino; Humans; Interferon alpha-2; Interferon-alpha; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Viral Load; White People | 2009 |
Stop codon read-through of a methylmalonic aciduria mutation.
Topics: Adenine; Chromosomes, Artificial, Bacterial; Cisplatin; Codon, Terminator; Genes, Reporter; Gentamicins; HeLa Cells; Humans; Metabolism, Inborn Errors; Methylmalonyl-CoA Mutase; Mutation, Missense; Organophosphonates; RNA, Messenger; Zidovudine | 2009 |
Can antiviral therapy for chronic hepatitis B enhance the progression to hepatocellular carcinoma?
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates | 2009 |
Clinical usefulness of sequential hepatitis B virus DNA measurement (the roadmap concept) during adefovir treatment in lamivudine-resistant patients.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Treatment Outcome | 2009 |
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.
Topics: Acids, Acyclic; Adenine; Antiviral Agents; Aza Compounds; Cidofovir; Cytosine; DNA Viruses; HeLa Cells; Humans; Molecular Structure; Nucleosides; Organophosphonates; RNA Viruses; Tenofovir | 2009 |
[Antiviral efficacy of lamivudine/adefovir combination therapy in chronic hepatitis b patients with resistance to lamivudine and adefovir consecutively].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors | 2009 |
[Treatment of hepatitis B virus resistant to lamivudine and adefovir].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2009 |
[Failure to treat hepatitis B virus infection with adefovir due to early selection of rtA181T mutation].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B Antigens; Hepatitis B virus; Humans; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Tenofovir; Time Factors; Treatment Failure | 2010 |
Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Base Composition; China; Computational Biology; Databases, Genetic; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Phylogeny; RNA-Directed DNA Polymerase; Treatment Failure; Virus Replication; Young Adult | 2009 |
Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antiviral Agents; Base Sequence; Child; Cohort Studies; DNA Primers; Drug Resistance, Viral; Female; Gene Products, pol; Genome, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Iran; Lamivudine; Male; Middle Aged; Organophosphonates; Point Mutation; Virus Replication; Young Adult | 2009 |
Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Viremia | 2009 |
Different models of HBeAg seroconversion predicated by on-treatment ALT and HBV DNA profiles.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Prognosis; Pyrimidinones; Retrospective Studies; Telbivudine; Thymidine; Young Adult | 2009 |
Combination of Lamivudine and adefovir therapy in HBeAg-positive chronic hepatitis B patients with poor response to adefovir monotherapy.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Enzymes; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2010 |
Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B.
Topics: Adenine; Adolescent; Antiviral Agents; Child; Drug Administration Schedule; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Young Adult | 2010 |
Low efficacy of entecavir therapy in adefovir-refractory hepatitis B patients with prior lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2010 |
Clinical outcome of lamivudine-resistant chronic hepatitis B patients with compensated cirrhosis under adefovir salvage treatment. Importance of HCC surveillance.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2009 |
[Factors associated with response to lamivudine: retrospective study of 233 patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Young Adult | 2009 |
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis, Biliary; Liver Transplantation; Middle Aged; Organophosphonates; Treatment Outcome | 2009 |
Hepatitis B in HIV patients: what is the current treatment and what are the challenges?
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Transaminases | 2009 |
The significance of enzyme immunoassay for the assessment of hepatitis B virus core-related antigen following liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoenzyme Techniques; Lamivudine; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Time Factors; Virus Replication | 2009 |
[Telbivudine in the management of HIV/HBV coinfection. Treating hepatitis B without HIV trouble].
Topics: Adenine; AIDS-Related Opportunistic Infections; Algorithms; Anti-HIV Agents; Antiviral Agents; Comorbidity; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Function Tests; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine | 2009 |
Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Organophosphonates | 2009 |
Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Design; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2009 |
Evolution of hepatitis B virus mutation during entecavir rescue therapy in patients with antiviral resistance to lamivudine and adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Evolution, Molecular; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome | 2009 |
Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Adolescent; Adult; Cohort Studies; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2010 |
Decrease in viral load at weeks 12 and 24 in patients with chronic hepatitis B treated with lamivudine or adefovir predicts virological response at week 48.
Topics: Adenine; Adult; Antiviral Agents; Female; Forecasting; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; Retrospective Studies; Reverse Transcriptase Inhibitors; Time Factors; Viral Load | 2009 |
Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy.
Topics: Adenine; Adult; Amino Acid Sequence; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Selection, Genetic; Sequence Alignment; Tenofovir; Treatment Failure; Viremia; Young Adult | 2010 |
[Protocol for the antiviral therapy of hepatitis B and D].
Topics: Adenine; Antiviral Agents; Biopsy; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis D; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver Cirrhosis; Nucleotides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
[The antiviral treatment impacts on clinical outcomes of renal transplantation recipients with hepatitis B virus infection].
Topics: Adenine; Adult; Aged; Antiviral Agents; Case-Control Studies; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2009 |
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
Topics: Adenine; Adult; Aged; Amino Acid Sequence; Amino Acid Substitution; Antiviral Agents; Codon, Initiator; Demography; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Point Mutation; Viral Proteins | 2010 |
Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Sensitivity and Specificity; Sequence Analysis, DNA; Young Adult | 2010 |
Hepatitis B genotypes and response to adefovir treatment in patients with HBV chronic infection.
Topics: Adenine; Antiviral Agents; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Treatment Outcome | 2010 |
Liver transplantation in bearers of hepatitis B associated or not with delta hepatitis in the age of the new antiviral drugs: is hyperimmune globulin still necessary?
Topics: Adenine; Adult; Aged; Antiviral Agents; Aspartate Aminotransferases; Female; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis D; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Recurrence; Retrospective Studies; Young Adult | 2010 |
Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Treatment Outcome; Viral Load | 2010 |
Naturally occurring hepatitis B virus (HBV) variants with primary resistance to antiviral therapy and S-mutants with potential primary resistance to adefovir in Argentina.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Argentina; Child; Child, Preschool; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Retrospective Studies | 2010 |
Viral resistance in hepatitis B: prevalence and management.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genetic Testing; Genotype; Guanine; Hepatitis B; Humans; Lamivudine; Nucleosides; Organophosphonates; Phenotype; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2010 |
[Serological and sociodemographic differences in HBV-patients with and without migration background].
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Comorbidity; Cross-Sectional Studies; Educational Status; Emigrants and Immigrants; Female; Germany; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Hepatitis C, Chronic; HIV Seropositivity; Humans; Incidence; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Outpatient Clinics, Hospital; Socioeconomic Factors; Unemployment; Viral Load; Young Adult | 2010 |
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cells, Cultured; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Microbial Sensitivity Tests; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2010 |
Metal ion-binding properties of 9-[(2-phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antiviral nucleotide analogue 9-[(2-phosphonomethoxy)ethyl]adenine (PMEA). Steric guiding of metal ion-coordination by the purine-amino group.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Coordination Complexes; Isomerism; Metals; Organophosphonates; Oxygen | 2010 |
[Genotype distribution of chronic hepatitis B and hepatitis C patients and investigation of the resistance patterns in hepatitis B cases].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA Mutational Analysis; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Young Adult | 2010 |
Cost-effectiveness of nucleoside analog therapy for hepatitis B in China: a Markov analysis.
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Models, Economic; Models, Statistical; Monte Carlo Method; Nucleosides; Organophosphonates; Pyrimidinones; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Serologic Tests; Telbivudine; Thymidine | 2010 |
Long-term outcome of renal transplant recipients with chronic hepatitis B infection-impact of antiviral treatments.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Diseases; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Viral Load | 2010 |
Peptide nucleic acid array for detection of point mutations in hepatitis B virus associated with antiviral resistance.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation, Missense; Oligonucleotide Array Sequence Analysis; Organophosphonates; Peptide Nucleic Acids; Point Mutation; Sensitivity and Specificity | 2010 |
Acute hepatitis B infection associated with drug-resistant hepatitis B virus.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Viral Proteins | 2010 |
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Asian People; DNA, Circular; DNA, Viral; Drug Resistance; Female; Gene Products, pol; Genetic Variation; Genome, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver; Liver Transplantation; Male; Middle Aged; Organophosphonates; Phylogeny; Tenofovir; Trans-Activators; Viral Envelope Proteins; Viral Regulatory and Accessory Proteins; Virus Replication | 2011 |
Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case.
Topics: Adenine; Amino Acid Motifs; Amino Acid Sequence; Antiviral Agents; Child; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Sequence Alignment | 2010 |
Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genes, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2010 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: comparison between entecavir 1.0 mg monotherapy, adefovir monotherapy and adefovir add-on lamivudine combination therapy.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2010 |
The curative efficiency of tenofovir for patients with chronic hepatitis B after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Remission Induction; Tenofovir; Treatment Failure | 2010 |
[Treatment of chronic hepatitis B. High response rate in general practice].
Topics: Adenine; Antiviral Agents; Cross-Sectional Studies; Germany; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Long-Term Care; Organophosphonates; Patient Care Team; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2010 |
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.
Topics: Adenine; Base Sequence; Databases, Genetic; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Genetic Association Studies; Genetic Variation; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Molecular Sequence Data; Multilocus Sequence Typing; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2010 |
Hepatitis B virus (HBV) subgenotypes C2 and B2 differ in lamivudine- and adefovir-resistance-associated mutational patterns in HBV-infected Chinese patients.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Asian People; China; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Prevalence; Young Adult | 2010 |
Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Young Adult | 2011 |
High rate of adefovir-lamivudine combination therapy in nucleoside-naïve patients with chronic hepatitis B in France: results of a national survey in 1730 patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Cross-Sectional Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Drug Utilization; Female; France; Health Care Surveys; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Practice Patterns, Physicians'; Registries; Retrospective Studies; Treatment Outcome; Viral Load; Young Adult | 2010 |
[Long-term therapy for chronic hepatitis B in HIV co-infected patients].
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine | 2010 |
[Treatment has a positive impact on the long-term evolution of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Clinical Trials as Topic; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Characteristics of adefovir resistance in patients with or without lamivudine-resistant hepatitis B virus treated with adefovir: a 4-year experience.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Cloning, Molecular; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Sequence Analysis, DNA; Time Factors | 2011 |
Pharmacokinetics and efficacy of intravenous or intramuscular hepatitis B immunoglobulins in prophylaxis of hepatitis B after liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Injections, Intramuscular; Injections, Intravenous; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prohibitins; Prospective Studies; Reverse Transcriptase Inhibitors; Secondary Prevention | 2010 |
Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome | 2011 |
Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.
Topics: Adenine; Adrenergic beta-1 Receptor Agonists; Animals; Antigens, Bacterial; Bacterial Toxins; Cyclic AMP; Dobutamine; Heart; Heart Rate; Male; Myocardium; Organophosphonates; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2011 |
The level of HBV DNA at month 12 is an important predictor of virological breakthrough during adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Treatment Outcome | 2011 |
Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).
Topics: Adenine; Antiviral Agents; Cell Line; Chromatography, High Pressure Liquid; Flavonoids; Humans; Kinetics; Organic Anion Transport Protein 1; Organophosphonates | 2011 |
Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load | 2011 |
[Efficacy of entecavir and adefovir combination therapy in patients with chronic hepatitis B refractory to lamivudine and adefovir combination therapy].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2011 |
Defining virologic relapse in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Treatment Outcome; Viral Load | 2011 |
Does the antiviral therapy of patients with chronic hepatitis exert nephrotoxic effects?
Topics: Adenine; Adult; Albuminuria; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Time Factors | 2011 |
Management of chronic hepatitis B patients: efficacy & limitation of nucleos(t)ide analogues.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Pilot Projects; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Virus Replication | 2011 |
[Design, synthesis and anti-hBV evaluation of adefovir mono-L-amino acid ester, mono non-steroidal anti-inflammatory drugs carboxylic ester prodrugs].
Topics: Adenine; Amino Acids; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Carboxylic Acids; Cell Survival; Drug Design; Hep G2 Cells; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Molecular Structure; Organophosphonates; Prodrugs | 2010 |
Adefovir-induced Stevens-Johnson syndrome and toxic epidermal necrolysis overlap syndrome.
Topics: Adenine; Antiviral Agents; Biopsy; Epidermis; Follow-Up Studies; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Male; Middle Aged; Organophosphonates; Photomicrography; Stevens-Johnson Syndrome | 2011 |
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Telbivudine; Thymidine; Viral Proteins | 2011 |
Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs.
Topics: Adenine; Adult; Elasticity Imaging Techniques; Female; Hepatitis B; Humans; Lamivudine; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2011 |
Hypophosphatemic osteomalacia as a long-term complication after liver transplantation.
Topics: Adenine; Aged; Fanconi Syndrome; Female; Humans; Hypophosphatemia; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Organophosphonates; Osteomalacia; Pain; Phosphates; Quality of Life; Treatment Outcome; Vitamin D | 2011 |
On-treatment monitoring of liver fibrosis with transient elastography in chronic hepatitis B patients.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biopsy; Disease Progression; Elasticity Imaging Techniques; Female; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Child; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Humans; Lamivudine; Luminescent Measurements; Male; Middle Aged; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Polymerase Chain Reaction; Protein Array Analysis; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2011 |
Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B.
Topics: Adenine; Adoptive Transfer; Antiviral Agents; DNA, Viral; Drug Combinations; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Leukemia, Myeloid, Acute; Lymphocyte Transfusion; Middle Aged; Organophosphonates; Peripheral Blood Stem Cell Transplantation; Taiwan; Treatment Outcome; Unrelated Donors | 2011 |
Two patterns of alanine aminotransferase increase to predict long-term viral response in chronic hepatitis B patients: virus- or host-induced?
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepacivirus; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-gamma; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Predictive Value of Tests; Pyrimidinones; T-Lymphocytes; Telbivudine; Thymidine; Treatment Outcome; Up-Regulation; Young Adult | 2011 |
New prodrugs of Adefovir and Cidofovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 2011 |
Effect of antiviral therapy on the immunohistochemical expression of bcl-xL and bax protein in patients with HBeAg-negative chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Biopsy; Female; Fibrosis; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Inflammation; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Retrospective Studies; Severity of Illness Index | 2011 |
Adefovir induced hypophosphatemic osteomalacia.
Topics: Adenine; Aged; Humans; Hypophosphatemia; Male; Organophosphonates; Osteomalacia; Radionuclide Imaging; Whole Body Imaging | 2011 |
Hepatitis: PEG-IFN for the treatment of hepatitis D.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Hepatitis D; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome | 2011 |
Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Recurrence; Time Factors | 2011 |
Changes of serum levels of keratin-18 fragments in hepatitis B e antigen-negative chronic hepatitis B patients under oral antiviral therapy.
Topics: Adenine; Administration, Oral; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Keratin-18; Lamivudine; Organophosphonates | 2011 |
Adefovir serum levels do not differ between responders and nonresponders.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Chromatography, High Pressure Liquid; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Failure | 2011 |
Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2011 |
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Middle Aged; Mutation; Organophosphonates; Tenofovir; Treatment Failure | 2011 |
[Improvement of health-related quality of life in chronic hepatitis B patients treated with entecavir or adefovir].
Topics: Adenine; Adult; Aged; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Quality of Life; Young Adult | 2011 |
The efficacy of entecavir therapy in chronic hepatitis B patients with suboptimal response to adevofir.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Regression Analysis; Time Factors; Treatment Outcome; Viral Load | 2011 |
A biomimetic chitosan derivates: preparation, characterization and transdermal enhancement studies of N-arginine chitosan.
Topics: Adenine; Administration, Cutaneous; Animals; Antiviral Agents; Arginine; Biomimetics; Cell-Penetrating Peptides; Chitosan; Diffusion Chambers, Culture; Drug Delivery Systems; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred Strains; Organophosphonates; Permeability; Skin; Skin Diseases; Spectroscopy, Fourier Transform Infrared | 2011 |
[Effect of shugan jianpi bushen recipe on splenic T lymphocytes and virus load in hepatitis B virus transgenic mice].
Topics: Adenine; Animals; Drugs, Chinese Herbal; Hepatitis B virus; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Organophosphonates; Spleen; T-Lymphocyte Subsets; Viral Load; Virus Replication | 2011 |
Management options for lamivudine-resistant chronic hepatitis B patients with suboptimal virological suppression by adefovir.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2011 |
Long-term efficacy of entecavir therapy in chronic hepatitis B patients with antiviral resistance to lamivudine and adefovir.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome; Viral Load | 2011 |
Long-term efficacy of entecavir in adefovir-refractory chronic hepatitis B patients with prior lamivudine resistance.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Salvage Therapy; Treatment Outcome | 2011 |
Virological response to adefovir monotherapy and the risk of adefovir resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies | 2011 |
Rapid high-performance liquid chromatographic method for determination of adefovir in plasma using UV detection: application to pharmacokinetic studies.
Topics: Adenine; Adult; Antiviral Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Indicators and Reagents; Male; Organophosphonates; Reference Standards; Reproducibility of Results; Solutions; Spectrophotometry, Ultraviolet | 2011 |
Adefovir-based combination therapy with entecavir or lamivudine for patients with entecavir-refractory chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
A prospective clinical study in hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessation criteria for adefovir.
Topics: Adenine; Adult; Antiviral Agents; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Treatment Outcome; Withholding Treatment; Young Adult | 2012 |
Potent hepatitis B surface antigen response to treatment of hepatitis-B-e-antigen-positive chronic hepatitis B with α-interferon plus a nucleos(t)ide analog.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; Time Factors; Young Adult | 2012 |
Efficacy of entecavir and adefovir combination therapy for patients with lamivudine- and entecavir-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Monitoring; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load; Virus Replication | 2012 |
Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Asian People; Child; Child, Preschool; China; Female; Genotype; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Mutation Rate; Organophosphonates; RNA-Directed DNA Polymerase; Virus Replication; Young Adult | 2012 |
Viral response at 6 months is associated with treatment outcome of adefovir add-on therapy for lamivudine-resistance.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Predictive Value of Tests; Proportional Hazards Models; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load | 2012 |
Antiviral efficacy of combination therapy with entecavir and adefovir for entecavir/lamivudine-resistant hepatitis B virus with or without adefovir resistance.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
Entecavir plus adefovir combination treatment for chronic hepatitis B patients after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Combinations; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Failure; Viral Load | 2012 |
Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Female; gamma-Glutamyltransferase; Hepatitis Antibodies; Hepatitis D; Hepatitis Delta Virus; Humans; Immunoglobulin M; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Young Adult | 2012 |
HBV DNA level at 24 weeks is the best predictor of virological response to adefovir add-on therapy in patients with lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
High-resolution melting and real-time PCR for quantification and detection of drug-resistant HBV mutants in a single amplicon.
Topics: Adenine; Antiviral Agents; DNA, Complementary; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Molecular Diagnostic Techniques; Nucleic Acid Denaturation; Organophosphonates; Pilot Projects; Polymerase Chain Reaction; Viral Load | 2012 |
Synthesis, anti-HBV activity and renal cell toxicity evaluation of mixed phosphonate prodrugs of adefovir.
Topics: Adenine; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Cell Line; Cell Survival; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Prodrugs | 2012 |
Virologic response is not durable after adefovir discontinuation in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Risk Factors | 2011 |
Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy.
Topics: Adenine; Adult; Amino Acid Substitution; Hepatitis B virus; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir | 2012 |
[Hungarian consensus guideline for the diagnosis and treatment of B, C, and D viral hepatitis].
Topics: Adenine; Antiviral Agents; Comorbidity; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Guanine; Hepacivirus; Hepatitis B; Hepatitis C; Hepatitis D; Humans; Hungary; Interferon-alpha; Interferons; Lamivudine; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.
Topics: Adenine; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cells, Cultured; Drug Interactions; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organophosphonates; Permeability; Verapamil; Vitamin D | 2012 |
Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Treatment Failure | 2012 |
[Prognosis analysis of hepatitis B virus recurrence after liver transplantation: a single-center study of 38 cases].
Topics: Adenine; Adult; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prognosis; Recurrence; Retrospective Studies | 2012 |
[Evaluation of the safety of pregnancy initiated by chronic hepatitis B fathers while taking adefovir].
Topics: Adenine; Adult; Female; Hepatitis B, Chronic; Humans; Infant, Newborn; Male; Organophosphonates; Paternal Exposure; Pregnancy | 2012 |
Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Tubules; Male; Middle Aged; Organophosphonates; Phosphates; Renal Insufficiency; Tenofovir; Time Factors; Uric Acid | 2012 |
High efficacy of adefovir and entecavir combination therapy in patients with nucleoside-refractory hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates | 2012 |
Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phylogeny; RNA-Directed DNA Polymerase; Treatment Failure | 2012 |
Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Nucleotides; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome; Young Adult | 2012 |
Acute liver failure resulting from discontinuation of nucleoside analogues in chronic hepatitis B patients: a report of two cases.
Topics: Adenine; Adult; Antiviral Agents; Guanine; Hepatitis B, Chronic; Histocytochemistry; Humans; Lamivudine; Liver Failure, Acute; Liver Transplantation; Male; Medication Adherence; Necrosis; Organophosphonates; Telbivudine; Thymidine | 2013 |
Prolonged adefovir therapy associated Fanconi syndrome and interstitial nephritis in hepatitis B.
Topics: Adenine; Drug Administration Schedule; Fanconi Syndrome; Hepatitis B; Humans; Male; Middle Aged; Nephritis, Interstitial; Organophosphonates; Time Factors | 2012 |
A case of adefovir-induced membranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease.
Topics: Adenine; Adolescent; Adult; Child, Preschool; Cholestasis, Intrahepatic; Drug Resistance, Viral; Female; Glomerulonephritis, Membranous; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Organophosphonates | 2012 |
Does genotype predict response to treatment in children infected with hepatitis B perinatally?
Topics: Adenine; Adolescent; Anti-Inflammatory Agents; Antiviral Agents; Child; Child, Preschool; Clinical Trials as Topic; DNA, Viral; Genotype; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Humans; Interferons; Lamivudine; Organophosphonates; Prednisolone; Treatment Outcome | 2012 |
Safety and efficacy of adefovir therapy for lamivudine-resistant hepatitis B virus infection in renal transplant recipients.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome | 2012 |
Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Statistics, Nonparametric; Time Factors; Treatment Outcome; Viremia; Young Adult | 2012 |
Evaluation of anti-HBV drug resistant mutations among patients with acute symptomatic hepatitis B in the United States.
Topics: Acute Disease; Adenine; Adult; Antiviral Agents; Cohort Studies; Cross-Sectional Studies; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B; Humans; Lamivudine; Male; Mutation; Organophosphonates; Retrospective Studies; Sequence Analysis, DNA; United States | 2013 |
The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Drug Approval; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Milk, Human; Netherlands; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pregnancy; Pregnancy Complications, Infectious; Renal Insufficiency; Telbivudine; Tenofovir; Thymidine | 2012 |
Multidrug-resistant hepatitis B virus resulting from sequential monotherapy with lamivudine, adefovir, and entecavir: clonal evolution during lamivudine plus adefovir therapy.
Topics: Adenine; Adult; Antiviral Agents; Clonal Evolution; DNA, Viral; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; RNA-Directed DNA Polymerase | 2013 |
Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice.
Topics: Adenine; Adult; Animals; Antiviral Agents; Disease Models, Animal; DNA, Viral; Female; Flow Cytometry; Hepatitis B Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Histocompatibility Antigens Class I; Humans; Immunohistochemistry; Immunosuppressive Agents; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily C; Organophosphonates; Viral Load | 2013 |
The efficacy of adefovir plus entecavir combination therapy in patients with chronic hepatitis B refractory to both lamivudine and adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Failure | 2013 |
The short-term efficacy of entecavir in lamivudine-resistant chronic hepatitis B: influence of sequential adefovir-refractoriness.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2013 |
Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.
Topics: Adenine; Adult; Antiviral Agents; Clonal Evolution; Drug Combinations; Drug Resistance, Viral; Drug Substitution; Gene Products, pol; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphates; Organophosphonates; Phenotype; Time Factors; Treatment Outcome | 2012 |
Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling, docking and dynamics simulation studies.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA-Directed DNA Polymerase; Genotype; Hepatitis B; Hepatitis B virus; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Organophosphonates; Sequence Alignment; Thermodynamics | 2013 |
Long-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: finite treatment duration unlikely.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Longitudinal Studies; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2013 |
Early viral suppression predicts good postoperative survivals in patients with hepatocellular carcinoma with a high baseline HBV-DNA load.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Disease-Free Survival; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Organophosphonates; Portal Vein; Proportional Hazards Models; Retrospective Studies; Risk Factors; Viral Load | 2013 |
Experience of anti-viral therapy in hepatitis B-associated membranous nephropathy, including Lamivudine-resistant strains.
Topics: Adenine; Adult; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Female; Glomerulonephritis, Membranous; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs.
Topics: Adenine; Adult; Alleles; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; HLA-DQ beta-Chains; Humans; Lamivudine; Male; Organophosphonates; RNA, Viral | 2013 |
[Antiviral therapy for patients with chronic hepatitis B with multi-drug resistance to nucleoside analogues].
Topics: Adenine; Aged; Aged, 80 and over; Antiviral Agents; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates | 2013 |
Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D.
Topics: Adenine; Aged; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2013 |
Use of ALLGIO probe assays for detection of HBV resistance to adefovir in patients with chronic hepatitis B, Kerman, Iran.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biological Assay; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleic Acid Probes; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies | 2012 |
Outcome of various treatments for posttransplant hepatitis B virus recurrence.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Treatment Outcome; Young Adult | 2013 |
[Effects of adefovir dipivoxil on liver pathology in patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Female; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
Telbivudine plus adefovir therapy for chronic hepatitis B patients with virological breakthrough or genotypic resistance to telbivudine.
Topics: Adenine; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Phenotype; Telbivudine; Thymidine; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2013 |
High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.
Topics: Adenine; Antiviral Agents; Codon, Nonsense; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation, Missense; Organophosphonates; RNA-Directed DNA Polymerase | 2013 |
Hepatitis B therapy, hepatocellular carcinoma and HBsAg mutants.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Surface Antigens; Humans; Immunohistochemistry; Lamivudine; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Real-Time Polymerase Chain Reaction; Tomography, X-Ray Computed | 2013 |
Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Creatinine; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates | 2013 |
Resolution of chronic hepatitis delta infection after five years of peginterferon-adefovir: lessons from a case report.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis D, Chronic; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral | 2013 |
A different look at the management of chronic hepatitis B in a resource-constrained country.
Topics: Adenine; Antiviral Agents; China; Drug Therapy, Combination; Health Resources; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Telbivudine; Thymidine | 2013 |
Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons.
Topics: Adenine; Bone and Bones; Humans; Hypophosphatemia; Lower Extremity; Male; Middle Aged; Organophosphonates; Osteomalacia; Radionuclide Imaging | 2013 |
[Cost-effectiveness of nucleoside/nucleotide analogues in chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Markov Chains; Models, Theoretical; Organophosphonates; Quality-Adjusted Life Years; Tenofovir | 2012 |
Prevention of de novo hepatitis B with adefovir plus vaccination in recipients of liver transplants from core antibody-positive donors.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Deoxycytidine; DNA, Viral; Drug Substitution; Emtricitabine; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Liver Transplantation; Middle Aged; Organophosphonates; Tenofovir; Time Factors; Tissue Donors; Treatment Outcome | 2013 |
Prevention of de novo hepatitis B in recipients of core antibody-positive livers with lamivudine and other nucleos(t)ides: a 12-year experience.
Topics: Adenine; Adult; Aged; Analysis of Variance; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Donor Selection; Female; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Logistic Models; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Tenofovir; Time Factors; Tissue Donors; Treatment Outcome; Viral Load | 2013 |
Reversible increase in FGF23 in a hypophosphatemic renal and bone disease linked to antiviral therapy by adefovir.
Topics: Adenine; Aged; Antiviral Agents; Bone Diseases; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Diseases; Organophosphonates | 2013 |
B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model.
Topics: Adenine; Animals; Antigens, Bacterial; Aorta; Bacterial Toxins; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Organophosphonates; Phenylephrine; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2013 |
Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Recurrence; Telbivudine; Thymidine; Treatment Outcome | 2013 |
Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Care; Proportional Hazards Models; Secondary Prevention; Survival Rate; Viral Load; Young Adult | 2013 |
Partial virological response to adefovir add-on lamivudine rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Area Under Curve; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; ROC Curve; Treatment Outcome | 2013 |
Comparison of re-treatment outcomes of lamivudine plus adefovir or entecavir in chronic hepatitis B patients with viral relapse after cessation of adefovir.
Topics: Adenine; Adult; Antiviral Agents; Case-Control Studies; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Organophosphonates; Prospective Studies; Recurrence; Treatment Outcome | 2013 |
Entecavir plus adefovir rescue therapy for chronic hepatitis B patients after multiple treatment failures in real-life practice.
Topics: Adenine; Adult; Antiviral Agents; Creatine Kinase; Creatinine; DNA, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Salvage Therapy; Treatment Outcome; Viral Load | 2013 |
Prophylaxis in HBV-infected liver transplant patients: end of the HBIG era?
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Organophosphonates | 2013 |
Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Hydrolysis; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Multidrug Resistance-Associated Proteins; Nelfinavir; Organophosphonates; Ritonavir | 2013 |
Living related liver transplantation for hepatitis B-related liver disease without hepatitis B immune globulin prophylaxis.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Immunosuppression Therapy; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir; Treatment Outcome | 2013 |
Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment.
Topics: Adenine; Adult; Aged; Antiviral Agents; Asian People; DNA, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hong Kong; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Young Adult | 2013 |
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Topics: Adenine; Adult; Cell Line; Codon, Nonsense; Drug Resistance, Viral; Female; Gene Expression; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocytes; Humans; Male; Middle Aged; Mutation; Organophosphonates; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Selection, Genetic; Treatment Failure | 2013 |
Chemokine receptor 5 (CCR5) polymorphism in chronic hepatitis B patients treated with three different nucleos(t)ide analogues.
Topics: Adenine; Alanine Transaminase; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Homozygote; Humans; India; Lamivudine; Liver Function Tests; Mutation; Nucleosides; Nucleotides; Organophosphonates; Pilot Projects; Polymorphism, Genetic; Receptors, CCR5; Telbivudine; Thymidine | 2013 |
Long-term efficacy and emergence of multidrug resistance in patients with lamivudine-refractory chronic hepatitis B treated by combination therapy with adefovir plus lamivudine.
Topics: Adenine; Adult; Aged; Asian People; DNA, Viral; Drug Resistance, Multiple; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Treatment Outcome | 2014 |
[Detection of resistance mutations in chronic hepatitis B patients receiving antiviral therapy for over one year].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Young Adult | 2013 |
Long-term efficacy of entecavir plus adefovir combination therapy versus entecavir monotherapy in adefovir refractory chronic hepatitis B patients with prior lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2014 |
In vivo antiviral activity of telbivudine against HIV-1: a case report.
Topics: Acute Disease; Adenine; Adult; Antiviral Agents; Coinfection; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Immunocompromised Host; Male; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2013 |
Combination lamivudine and adefovir versus entecavir for the treatment of naïve chronic hepatitis B patients: a pilot study.
Topics: Adenine; Adult; Alanine Transaminase; Analysis of Variance; Aspartate Aminotransferases; Bilirubin; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects | 2013 |
Real-world application of the roadmap model in chronic hepatitis B patients with telbivudine therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2013 |
Analysis and simulation of an Adefovir anti-hepatitis B virus infection therapy immune model with alanine aminotransferase.
Topics: Adenine; Alanine Transaminase; Algorithms; Antiviral Agents; Computer Simulation; DNA, Viral; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Immune System; Liver; Organophosphonates; T-Lymphocytes, Cytotoxic | 2013 |
BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue.
Topics: Adenine; Adipocytes; DNA Fragmentation; DNA, Mitochondrial; Epithelial Cells; Humans; Kidney Tubules, Proximal; Mitochondria; Muscle Fibers, Skeletal; Organophosphonates; Primary Cell Culture; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Tenofovir; Thymidine | 2013 |
[Outcome of chronic hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive drugs and anti-TNF agents].
Topics: Adalimumab; Adenine; Adult; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azathioprine; Crohn Disease; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Organophosphonates; Tumor Necrosis Factor-alpha; Viral Load; Viremia; Virus Activation | 2014 |
Efficacy of adefovir-based combination therapy for patients with Lamivudine- and entecavir-resistant chronic hepatitis B virus infection.
Topics: Adenine; Adult; Aged; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome | 2013 |
HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D.
Topics: Adenine; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2014 |
Lamivudine plus adefovir combination therapy for lamivudine resistance in hepatitis-B-related hepatocellular carcinoma patients.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2013 |
Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population.
Topics: Adenine; Adult; Aged; Amino Acid Motifs; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Case-Control Studies; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Methionine; Middle Aged; Mutation; Organophosphonates; Prognosis; Retrospective Studies; Turkey; Tyrosine | 2013 |
Two rescue therapies in lamivudine-resistant patients with chronic hepatitis B in the central China: adefovir monotherapy and adefovir plus lamivudine.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; China; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Salvage Therapy; Treatment Outcome | 2014 |
Incorporated antivirals for chronic hepatitis B in Brazil: a cost-effectiveness analysis.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; Brazil; Cost-Benefit Analysis; Disease Progression; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Organophosphonates; Tenofovir; Treatment Outcome | 2013 |
Telbivudine protects renal function in patients with chronic hepatitis B infection in conjunction with adefovir-based combination therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2014 |
Na⁺/H⁺ exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Carrier Proteins; HEK293 Cells; Humans; Kidney; Membrane Proteins; Mice; Multidrug Resistance-Associated Proteins; Organophosphonates; Up-Regulation | 2014 |
Efficacy of 2years of entecavir plus adefovir therapy in patients with chronic hepatitis B who had failed on prior nucleos(t)ide analog treatment.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Retrospective Studies; Salvage Therapy; Treatment Outcome | 2014 |
Rapid detection of hepatitis B virus variants associated with lamivudine and adefovir resistance by multiplex ligation-dependent probe amplification combined with real-time PCR.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Molecular Diagnostic Techniques; Multiplex Polymerase Chain Reaction; Mutation; Organophosphonates; Real-Time Polymerase Chain Reaction; Sensitivity and Specificity; Time | 2014 |
Efficacy of tenofovir in adefovir-experienced patients compared with treatment-naive patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2014 |
Dynamic comparison between Daan real-time PCR and Cobas TaqMan for quantification of HBV DNA levels in patients with CHB.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Prospective Studies; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Viral Load; Young Adult | 2014 |
Long-term observation of osteomalacia caused by adefovir-induced Fanconi's syndrome.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia | 2014 |
[Patient with HBsAg negativization during treatment. Could it be considered a cure for hepatitis B?].
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B; Hepatitis B Surface Antigens; Humans; Male; Organophosphonates; Remission Induction | 2014 |
Generation of a human hepatoma cell line supporting efficient replication of a lamivudine resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hep G2 Cells; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Organophosphonates; Tenofovir; Virus Replication | 2014 |
Lamivudine and Adefovir Motif Variants Detected in chronic Hepatıtıs B patients.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Protein Domains | 2014 |
[Detection and analysis of HBV in polymorphonuclear neutrophils of patients with hepatitis B].
Topics: Adenine; Adult; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Neutrophils; Organophosphonates | 2014 |
Successful withdrawal of antiviral treatment in kidney transplant recipients with chronic hepatitis B viral infection.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Time Factors; Virus Activation; Withholding Treatment | 2014 |
[Diagnosis and treatment of chronic hepatitis B and D. Hungarian national consensus guideline].
Topics: Adenine; Antiviral Agents; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Hungary; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2014 |
Corrective osteotomy in femoral non-union in drug-induced hypophosphataemic osteomalacia.
Topics: Adenine; Antiviral Agents; Femoral Neck Fractures; Fracture Fixation, Intramedullary; Fractures, Ununited; Humans; Male; Middle Aged; Organophosphonates; Osteotomy; Rickets, Hypophosphatemic | 2014 |
[A case of the patient with HBeAg-negative chronic hepatitis B recurrence after retreatment with adefovir occurred HBsAg seroconversion].
Topics: Adenine; Adult; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Recurrence; Treatment Outcome | 2013 |
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Papillomavirus Infections; Prodrugs; Structure-Activity Relationship; Tenofovir; Tumor Cells, Cultured | 2014 |
Effects of entecavir on peripheral blood lymphocyte profiles in chronic hepatitis B patients with suboptimal responses to adefovir.
Topics: Adenine; Antiviral Agents; B-Lymphocytes; Case-Control Studies; CD4-Positive T-Lymphocytes; DNA, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tumor Necrosis Factor Receptor Superfamily, Member 7; Viral Load | 2014 |
Analysis of reverse transcriptase gene mutations in the hepatitis B virus at a university hospital in Korea.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hospitals, University; Humans; Lamivudine; Mutation; Organophosphonates; Phenotype; Republic of Korea; Retrospective Studies; RNA-Directed DNA Polymerase | 2014 |
HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.
Topics: Adenine; Adult; Antiviral Agents; Carnitine; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Monocarboxylic Acid Transporters; Organophosphonates; Polyethylene Glycols; Polymorphism, Single Nucleotide; Prognosis; Recombinant Proteins; Treatment Outcome; Vitamin B Complex | 2014 |
Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Recombinant Proteins; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load | 2014 |
Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection.
Topics: Adenine; Adult; Antiviral Agents; China; Clone Cells; Drug Resistance, Viral; Female; Gene Expression; Genotype; Guanine; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Phenotype; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Viral Proteins | 2015 |
Adefovir and lamivudine combination therapy in patients with entecavir-resistant chronic hepatitis B: antiviral responses and evolution of mutations.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prospective Studies; Serum; Treatment Outcome; Viral Load | 2014 |
HBsAg clearance by Peg-interferon addition to a long-term nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Time Factors; Treatment Outcome; Viral Load | 2014 |
Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Child; China; Cohort Studies; DNA Replication; Drug Resistance, Viral; Female; Genes, Viral; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Virus Replication; Young Adult | 2014 |
Rescue therapy with adefovir in decompensated liver cirrhosis patients with lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Odds Ratio; Organophosphonates; Retrospective Studies; Severity of Illness Index; Survival Rate | 2014 |
Antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2014 |
Mechanisms of hepatitis B virus resistance development.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Deoxycytidine; Drug Resistance, Multiple, Viral; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2014 |
Hepatitis B virus drug resistance tools: one sequence, two predictions.
Topics: Adenine; Antiviral Agents; Base Sequence; Drug Resistance, Multiple, Viral; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Evasion; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Telbivudine; Tenofovir; Thymidine | 2014 |
[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia].
Topics: Adenine; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Osteomalacia | 2014 |
Treatment cessation in noncirrhotic, e-antigen negative chronic hepatitis B is safe and effective following prolonged anti-viral suppression with nucleosides/nucleotides.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Recurrence; Tenofovir; Withholding Treatment; Young Adult | 2014 |
Safety and efficacy of entecavir in adefovir-experienced patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Drug Substitution; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2015 |
Adefovir as a possible teratogen: evidence from paternal exposure.
Topics: Adenine; Adult; Antiviral Agents; Female; Heart Defects, Congenital; Humans; Male; Organophosphonates; Paternal Exposure; Pregnancy; Teratogens; Ultrasonography, Prenatal | 2014 |
Differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virus.
Topics: Adenine; Adenosine Triphosphate; Binding Sites; Cluster Analysis; Crystallography, X-Ray; Deoxyguanine Nucleotides; Drug Resistance, Viral; Hepatitis B virus; Ligands; Models, Molecular; Mutation; Nucleotides; Open Reading Frames; Organophosphonates; Protein Binding; RNA-Directed DNA Polymerase; Tenofovir; Thermodynamics | 2014 |
[Retrospective analysis of the efficacy and safety of anti-hepatitis B virus drugs taken during pregnancy in women from the Guangdong Province].
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Male; Mothers; Organophosphonates; Pregnancy; Retrospective Studies; Telbivudine; Thymidine; Time Factors | 2014 |
The feasibility of discontinuing lamivudine in lamivudine-resistant chronic hepatitis B patients on lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Feasibility Studies; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Treatment Outcome; Young Adult | 2014 |
Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2015 |
Different mechanism of selection of adefovir-resistant mutant viruses during adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation Rate; Mutation, Missense; Organophosphonates; Point Mutation; Retrospective Studies; RNA-Directed DNA Polymerase; Selection, Genetic; Young Adult | 2014 |
The incidence of hepatocellular carcinoma is reduced in patients with chronic hepatitis B on long-term nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Antiviral Agents; Canada; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Nucleosides; Organophosphonates; Retrospective Studies; Risk Factors; Telbivudine; Tenofovir; Thymidine | 2014 |
Long-term outcomes of two rescue therapies in lamivudine-refractory patients with chronic hepatitis B: combined lamivudine and adefovir, and 1-mg entecavir.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2014 |
Effect of Peg-interferon α-2a combined with Adefovir in HBV postpartum women with normal levels of ALT and high levels of HBV DNA.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Postpartum Period; Pregnancy; Prospective Studies; Recombinant Proteins; Telbivudine; Thymidine; Treatment Outcome | 2015 |
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Organic Anion Transport Protein 1; Organophosphonates; Tenofovir; Toxicity Tests | 2015 |
[Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Treatment Outcome | 2014 |
Bone and kidney toxicity induced by nucleotide analogues in patients affected by HBV-related chronic hepatitis: a longitudinal study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Bone Diseases; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration Rate; Hematuria; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Diseases; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Proteinuria; Vitamin D Deficiency | 2015 |
[Promotion of HBeAg seroconversion/loss in patients with chronic hepatitis B following the switch from nucleoside drugs to telbivudine and adefovir].
Topics: Adenine; Drug Combinations; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Nucleic Acid Synthesis Inhibitors; Nucleosides; Organophosphonates; Telbivudine; Thymidine | 2014 |
[Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by adefovir in a patient with chronic hepatitis B].
Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia | 2014 |
Response-guided treatment of cirrhotic chronic hepatitis B patients: multicenter prospective study.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; China; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Mutation; Organophosphonates; Prospective Studies; Time Factors; Treatment Outcome; Viral Load | 2015 |
HBV carrying drug-resistance mutations in chronically infected treatment-naive patients.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Brazil; DNA, Viral; Drug Resistance, Viral; Gene Products, pol; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation; Organophosphonates; Retrospective Studies; Sequence Analysis, DNA; Tenofovir; Virus Replication | 2015 |
[Case report; A case of Fanconi's syndrome with pathological ulnar fractures improved by dose reduction of adefovir and supplementation of oral phosphate].
Topics: Adenine; Administration, Oral; Aged; Antiviral Agents; Fanconi Syndrome; Female; Fractures, Spontaneous; Hepatitis B; Humans; Organophosphonates; Phosphates; Ulna | 2014 |
Low-dose short-term hepatitis B immunoglobulin with high genetic barrier antivirals: the ideal post-transplant hepatitis B virus prophylaxis?
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir | 2015 |
Comparison of the efficacies of entecavir 0.5 and 1.0 mg combined with adefovir in patients with chronic hepatitis B who had failed on prior nucleos(t)ide analogue treatments.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Time Factors; Treatment Failure; Treatment Outcome; Viral Load; Young Adult | 2015 |
Analysis of HBV genotype, drug resistant mutations, and pre-core/basal core promoter mutations in Korean patients with acute hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; Prospective Studies; Republic of Korea; Viral Core Proteins; Virus Replication | 2015 |
Tenofovir rescue regimen following prior suboptimal response to entecavir and adefovir combination therapy in chronic hepatitis B patients exposed to multiple treatment failures.
Topics: Adenine; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; ROC Curve; Tenofovir; Treatment Failure; Treatment Outcome | 2015 |
Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load; Viral Matrix Proteins; Young Adult | 2015 |
[Clinical emergence features and implications of hepatitis B virus rtA181T mutation].
Topics: Adenine; Antiviral Agents; China; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates | 2015 |
Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery.
Topics: Adenine; Antiviral Agents; Drug Delivery Systems; Humans; Nucleotides; Organophosphonates; Phosphorus Compounds; Prodrugs; Stavudine | 2015 |
Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Substitution; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Medical Records; Middle Aged; Organophosphonates; Phosphorous Acids; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2015 |
Water-compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine.
Topics: Adenine; Humans; Hydrogen-Ion Concentration; Molecular Imprinting; Organophosphonates; Polymers; Reverse Transcriptase Inhibitors; Spectrophotometry, Infrared; Thermodynamics; Water | 2015 |
Natural Killer Cell Characteristics in Patients With Chronic Hepatitis B Virus (HBV) Infection Are Associated With HBV Surface Antigen Clearance After Combination Treatment With Pegylated Interferon Alfa-2a and Adefovir.
Topics: Adenine; Adult; Aged; Antigens, Surface; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Killer Cells, Natural; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2015 |
Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy.
Topics: Adenine; Adult; Antiviral Agents; Clonal Evolution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2015 |
Impact of nucleos(t)ide analogue combination therapy on the estimated glomerular filtration rate in patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine | 2015 |
Entecavir Combined With Adefovir Ameliorates Patients With Chronic Hepatitis B Who Fail to Respond to Nucleotide (Acid) Analog Monotherapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome | 2017 |
Nucleoside-Nucleotide Analog Combination Therapy Is Effective in Preventing Recurrent Hepatitis B After Liver Transplantation.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir | 2015 |
Tenofovir-based rescue therapy in chronic hepatitis B patients with suboptimal responses to adefovir with prior lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Tenofovir; Time Factors; Young Adult | 2015 |
Efficacy of Tenofovir-based Rescue Therapy in Lamivudine-resistant Chronic Hepatitis B Patients With Failure of Lamivudine and Adefovir Combination.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retreatment; Tenofovir; Time Factors; Treatment Outcome | 2015 |
Tenofovir-based rescue therapy for chronic hepatitis B patients who had failed treatment with lamivudine, adefovir, and entecavir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir; Treatment Failure | 2015 |
Prevalence and types of drug-resistant variants in Chinese patients with acute hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Genetic Variation; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Prevalence; RNA-Directed DNA Polymerase; Telbivudine; Thymidine; Time Factors; Young Adult | 2015 |
Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Child; Codon; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Virus Replication; Young Adult | 2016 |
The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Follow-Up Studies; Forecasting; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Italy; Lamivudine; Liver; Liver Cirrhosis; Male; Middle Aged; Nucleosides; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Survival Rate; Tenofovir | 2015 |
[Efficacy and safety of telbivudine alone and combined with adefovir for the treatment of nucleos(t)ide-naive chronic hepatitis B in patients with high-level hepatitis B virus load].
Topics: Adenine; Alanine Transaminase; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2015 |
Comparison of entecavir monotherapy and de novo lamivudine and adefovir combination therapy in HBeAg-positive chronic hepatitis B with high viral load: 48-week result.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Blood; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Treatment Outcome; Viral Load; Young Adult | 2016 |
Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.
Topics: Adenine; Antiviral Agents; Drug Design; Guanine; Hep G2 Cells; Hepatitis B virus; Humans; In Vitro Techniques; Organophosphonates | 2015 |
Outcome of adefovir add-on lamivudine rescue therapy of up to 5 years in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; ROC Curve; Time Factors; Treatment Outcome | 2016 |
Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Models, Molecular; Organophosphonates; Tenofovir; Virus Replication | 2015 |
Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance.
Topics: Adenine; Adenosine; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Databases, Protein; Drug Resistance, Viral; Gene Products, pol; Guanine; Hepatitis B; Hepatitis B virus; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Organophosphonates; Sequence Alignment; Tenofovir | 2015 |
Adefovir- or Lamivudine-Induced Renal Tubular Dysfunction after Liver Transplantation.
Topics: Adenine; Female; Hepatitis B; Humans; Incidence; Kidney Diseases; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Recurrence; Republic of Korea; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors | 2015 |
Long-term follow-up of HBsAg-positive patients in Germany.
Topics: Adenine; Adult; Age Factors; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Germany; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Mass Screening; Middle Aged; Organophosphonates; Prognosis; Prospective Studies; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Time Factors; Turkey | 2016 |
Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viral Load; Young Adult | 2015 |
Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.
Topics: Adenine; Administration, Oral; Animals; Area Under Curve; Biological Availability; Calcitriol; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Entecavir plus tenofovir versus entecavir plus adefovir in chronic hepatitis B patients with a suboptimal response to lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Odds Ratio; Organophosphonates; Real-Time Polymerase Chain Reaction; Retrospective Studies; Tenofovir; Viral Load | 2015 |
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Ethnicity; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Epidemiology; Mutation; Organophosphonates; Prevalence | 2015 |
Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Hospitals; Humans; Incidence; Kidney Diseases; Lamivudine; Male; Middle Aged; Nephrons; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Telbivudine; Tenofovir; Thailand; Thymidine; Tropical Medicine | 2015 |
Development and Validation of a Sensitive LC-MS-MS Method for the Determination of Adefovir in Human Serum and Urine: Application to a Clinical Pharmacokinetic Study.
Topics: Adenine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Organophosphonates; Reproducibility of Results; Reverse Transcriptase Inhibitors; Tandem Mass Spectrometry | 2016 |
Rhabdomyolysis due to lamivudine re-administration in a patient with HBV-related hepatic failure caused by interruption of lamivudine and adefovir.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Failure; Male; Medication Adherence; Middle Aged; Organophosphonates; Rhabdomyolysis | 2015 |
[Efficacy of combination antiviral therapy following childbirth in pregnant HBV carriers receiving telbivudine for prevention of mother-to-child transmission].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Carrier State; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Vertical; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Recombinant Proteins; Telbivudine; Thymidine | 2015 |
A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.
Topics: 3T3 Cells; Adenine; Animals; Antiviral Agents; Cell Line; Cell Line, Transformed; Cell Survival; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Forecasting; Gene Expression Regulation; HEK293 Cells; Humans; Kidney Tubules, Proximal; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates | 2016 |
Off-treatment efficacy of 3-year nucleos(t)ide analogues in chronic hepatitis B patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2016 |
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection.
Topics: Adenine; Case-Control Studies; DNA Probes; DNA, Viral; Hep G2 Cells; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; In Situ Hybridization; Liver; Organophosphonates; RNA, Viral; Sensitivity and Specificity; Virus Replication | 2016 |
[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; Telbivudine; Tenofovir; Thymidine | 2016 |
Profile of HBV polymerase gene mutations during entecavir treatment in patients with chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load; Young Adult | 2016 |
Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Amino Acid Sequence; Antiviral Agents; Biopsy; Carcinoma, Hepatocellular; DNA, Circular; Drug Resistance, Viral; Fatty Liver; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Lamivudine; Liver; Liver Neoplasms; Male; Middle Aged; Necrosis; Organophosphonates; Protein Precursors; Sequence Deletion; Viral Load; Young Adult | 2016 |
Cost-effectiveness comparison of lamivudine plus adefovir combination treatment and nucleos(t)ide analog monotherapies in Chinese chronic hepatitis B patients.
Topics: Adenine; Adult; Cost-Benefit Analysis; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2016 |
Compartmental approach to assess bioequivalence compared to the noncompartmental approach.
Topics: Adenine; Finasteride; Humans; Monte Carlo Method; Organophosphonates; Therapeutic Equivalency; Tyrosine | 2016 |
Hepatitis B virus related cryoglobulinemic vasculitis: A multicentre open label study from the Gruppo Italiano di Studio delle Crioglobulinemie - GISC.
Topics: Adenine; Aged; Antiviral Agents; Cryoglobulinemia; Female; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Italy; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Vasculitis | 2016 |
Intrahepatic IP-10 mRNA and plasma IP-10 levels as response marker for HBeAg-positive chronic hepatitis B patients treated with peginterferon and adefovir.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Biopsy; Chemokine CXCL10; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; RNA, Messenger; Treatment Outcome | 2016 |
Cost-Effectiveness of Peg-Interferon, Interferon and Oral Nucleoside Analogues in the Treatment of Chronic Hepatitis B and D Infections in China.
Topics: Adenine; Adult; Age Factors; Aged; Antiviral Agents; China; Cohort Studies; Cost of Illness; Cost-Benefit Analysis; Drug Costs; Female; Hepatitis B, Chronic; Hepatitis D, Chronic; Humans; Interferons; Male; Markov Chains; Middle Aged; Nucleosides; Organophosphonates; Palliative Care; Quality-Adjusted Life Years | 2016 |
First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome.
Topics: Absorptiometry, Photon; Adenine; Alanine; Coinfection; Dose-Response Relationship, Drug; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2016 |
Cost-effectiveness analysis of tenofovir disoproxil fumarate for treatment of chronic hepatitis B in China.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Markov Chains; Organophosphonates; Quality-Adjusted Life Years; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2016 |
The efficacy of tenofovir-based therapy in patients showing suboptimal response to entecavir-adefovir combination therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Republic of Korea; Retrospective Studies; Tenofovir; Treatment Outcome | 2016 |
Durability of the virological response after lamivudine discontinuation in lamivudine-resistant patients with a complete virological response after lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Sustained Virologic Response; Time Factors; Withholding Treatment | 2017 |
A five years study of antiviral effect of entecavir in Chinese chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; Asian People; China; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2016 |
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
Topics: Adenine; Animals; Choline; Diet; Glomerular Filtration Rate; Kidney; Male; Methionine; Non-alcoholic Fatty Liver Disease; Organophosphonates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors | 2016 |
Nucleos(t)ide analog(s) prophylaxis after hepatitis B immunoglobulin withdrawal against hepatitis B and D recurrence after liver transplantation.
Topics: Adenine; Adult; Antiviral Agents; Coinfection; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome; Withholding Treatment; Young Adult | 2016 |
[HBsAg clearance rate in patients with HBeAg-positive chronic hepatitis B: a comparative effect analysis based on the real world].
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; Cohort Studies; Disease Management; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viral Load | 2017 |
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2016 |
Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Biopsy; DNA, Circular; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Male; Middle Aged; Nucleosides; Organophosphonates; Outcome Assessment, Health Care; Telbivudine; Thymidine; Time; Virus Replication | 2017 |
Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients.
Topics: Adenine; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Mutation; Organophosphonates; Polymorphism, Single Nucleotide | 2016 |
The Effect of Prophylactic Lamivudine plus Adefovir Therapy Compared with Lamivudine Alone in Preventing Hepatitis B Reactivation in Lymphoma Patients with High Baseline HBV DNA during Chemotherapy.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; DNA, Viral; Drug Interactions; Female; Hepatitis B virus; Humans; Lamivudine; Lymphoma; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk; Virus Activation; Young Adult | 2016 |
Comparison of the clinical outcomes between antiviral-naïve patients treated with entecavir and lamivudine-resistant patients receiving adefovir add-on lamivudine combination treatment.
Topics: Adenine; Adult; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Disease Progression; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2016 |
Identification of a new hepatitis B virus recombinant D2/D3 in the city of São Paulo, Brazil.
Topics: Adenine; Adult; Aged; Antiviral Agents; Brazil; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Lamivudine; Male; Middle Aged; Molecular Epidemiology; Mutation; Organophosphonates; Phylogeny; Reassortant Viruses; Recombination, Genetic; Retrospective Studies | 2017 |
Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asymptomatic Infections; Carcinoma, Hepatocellular; Culture Media, Conditioned; DNA, Viral; Female; Gene Expression; Genotype; Guanine; Hep G2 Cells; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HT29 Cells; Humans; Interferons; Interleukins; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Polymorphism, Genetic; Recombinant Proteins; Tenofovir; Up-Regulation; Young Adult | 2018 |
Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China.
Topics: Adenine; Adult; Antiviral Agents; China; Cohort Studies; Drug Resistance, Multiple, Viral; Female; Gene Expression; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Middle Aged; Mutation Rate; Organophosphonates; Phylogeny; Viral Proteins | 2017 |
Comparison of the Efficacies and Safety of Combined Therapy between Telbivudine Plus Adefovir and Lamivudine Plus Adefovir in Patients with Hepatitis B Virus Infection in Real-World Practice.
Topics: Adenine; Adult; Biomarkers; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Circulating kidney injury molecule-1 is a novel diagnostic biomarker for renal dysfunction during long-term adefovir therapy in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Cohort Studies; Female; Hepatitis A Virus Cellular Receptor 1; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Renal Insufficiency, Chronic; Retrospective Studies | 2016 |
DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long-term nucleo(t)side analogs therapy.
Topics: Adenine; Aged; Antiviral Agents; Cross-Sectional Studies; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA, Mitochondrial; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Nucleosides; Organophosphonates; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine | 2017 |
A novel pretreatment method combining sealing technique with direct injection technique applied for improving biosafety.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Humans; Limit of Detection; Organophosphonates; Tenofovir; Ultrafiltration; Virus Diseases | 2017 |
Tenofovir disoproxil fumarate monotherapy maintains HBV suppression achieved by a "de novo" combination of lamivudine-adefovir: a pilot study.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Italy; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Tenofovir; Treatment Outcome; Viral Load | 2016 |
Long-term efficacy and safety of switching from lamivudine+adefovir to tenofovir disoproxil fumarate in virologically suppressed patients.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Italy; Kaplan-Meier Estimate; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2017 |
Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naïve patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Nucleotides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Tenofovir; Treatment Outcome | 2017 |
Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment.
Topics: Adenine; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Evolution, Molecular; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymorphism, Genetic; RNA-Directed DNA Polymerase; Sequence Analysis; Tenofovir; Treatment Failure | 2017 |
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Cell Proliferation; Cell Survival; Glucose; Glycolysis; HSP90 Heat-Shock Proteins; Humans; Kidney Diseases; Mice; Mitochondria; Models, Biological; Organophosphonates; Proteome; Proteomics; Succinate Dehydrogenase; Tenofovir | 2017 |
A different inhibitor is required for overcoming entecavir resistance: a comparison of four rescue therapies in a retrospective study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Practice Guidelines as Topic; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load | 2017 |
Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients.
Topics: Adenine; Adjuvants, Immunologic; Adult; Antigen-Antibody Complex; Combined Modality Therapy; Female; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interleukin-10; Interleukin-17; Interleukin-2; Male; Organophosphonates; Th1 Cells; Th2 Cells; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein.
Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir | 2017 |
Adefovir-Induced Hypophosphatemic Osteomalacia Mimicking Bone Metastases From Primary Hepatocarcinoma.
Topics: Adenine; Bone Neoplasms; Humans; Hypophosphatemia; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Osteomalacia; Single Photon Emission Computed Tomography Computed Tomography | 2017 |
Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis.
Topics: Acidosis, Lactic; Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lactic Acid; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Risk Factors; Sex Factors; Tenofovir; Time Factors; Treatment Outcome; Up-Regulation; Young Adult | 2017 |
Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Interferon-alpha; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Promoter Regions, Genetic; Prospective Studies; Recombinant Proteins; Viral Load | 2017 |
Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B; Humans; Male; Middle Aged; Nephrolithiasis; Organophosphonates; Osteomalacia | 2017 |
Adefovir-induced Fanconi syndrome associated with osteomalacia.
Topics: Adenine; Adult; Bone and Bones; Fanconi Syndrome; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Hepatitis B; Humans; Hypophosphatemia; Kidney Tubules, Proximal; Mitochondria; Organophosphonates; Osteomalacia | 2018 |
Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.
Topics: Adenine; Animals; Antigens, Bacterial; Aorta; Arterial Pressure; Arteries; Bacterial Toxins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Organophosphonates; Phenylephrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Shock; Vasoconstrictor Agents | 2017 |
Efficacy and safety of three adefovir-based combination therapies in HBeAg-positive chronic hepatitis B patients with suboptimal response to adefovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Liver; Liver Function Tests; Male; Organophosphonates; Treatment Outcome; Viral Load | 2017 |
Effective viral suppression is necessary to reduce hepatocellular carcinoma development in cirrhotic patients with chronic hepatitis B: Results of a 10-year follow up.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Kaplan-Meier Estimate; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Prospective Studies; Risk Factors; Sustained Virologic Response; Time Factors; Treatment Outcome; Viral Load | 2017 |
Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1).
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Apigenin; Cell Survival; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Herb-Drug Interactions; Inhibitory Concentration 50; Kidney Diseases; Madin Darby Canine Kidney Cells; Male; Organic Anion Transport Protein 1; Organophosphonates; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Time Factors | 2017 |
Direct Detection of Drug-Resistant Hepatitis B Virus in Serum Using a Dendron-Modified Microarray.
Topics: Adenine; Dendrimers; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microarray Analysis; Mutation; Nucleic Acid Amplification Techniques; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Seroclearance of hepatitis B surface antigen following hepatitis E exacerbation on chronic hepatitis E and B dual infection in a renal transplant recipient: a case report.
Topics: Adenine; Coinfection; Disease Progression; DNA, Viral; Female; Graft Rejection; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis E; Hepatitis E virus; Humans; Immunosuppressive Agents; Kidney Transplantation; Lamivudine; Medication Adherence; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Tacrolimus | 2018 |
Injectable PLGA Adefovir microspheres; the way for long term therapy of chronic hepatitis-B.
Topics: Adenine; Animals; Antiviral Agents; Drug Delivery Systems; Drug Liberation; Hepatitis B, Chronic; Lactic Acid; Male; Microspheres; Organophosphonates; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats | 2018 |
Osteomalacia Due to Drug-Induced Fanconi Syndrome.
Topics: Adenine; Aged; Antiviral Agents; Fanconi Syndrome; Hepatitis B; Humans; Male; Organophosphonates; Osteomalacia | 2018 |
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase | 2018 |
Chronic hepatitis B virus and liver fibrosis: A mathematical model.
Topics: Adenine; Computer Simulation; Diffusion; Drug Delivery Systems; Hepatic Stellate Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inflammation; Interferon-alpha; Liver Cirrhosis; Macrophages; Models, Theoretical; Organophosphonates; Th2 Cells | 2018 |
Combination therapy for chronic hepatitis B: The future and beyond.
Topics: Adenine; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2018 |
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Topics: Adenine; Amino Acids; Animals; Antiviral Agents; Cell Line; Cercopithecidae; Dogs; Drug-Related Side Effects and Adverse Reactions; HEK293 Cells; Humans; Kidney; Kinetics; Macaca fascicularis; Mice; Organic Anion Transport Protein 1; Organophosphonates; Rats; Species Specificity; Uric Acid | 2018 |
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
Topics: Adenine; Adenylyl Cyclases; Bacillus anthracis; Bordetella pertussis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Molecular Structure; Organophosphonates; Structure-Activity Relationship | 2018 |
Long-term results of chronic hepatitis B antiviral treatment with nucleos(t)ide analogues: a single center experience.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Young Adult | 2019 |
Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Interferon-alpha; Linear Models; Male; Middle Aged; Models, Molecular; Organophosphonates; Polyethylene Glycols; Protein Conformation; Recombinant Proteins; Sequence Alignment; Sequence Analysis, Protein; Sequence Homology; Viral Core Proteins | 2018 |
[A Case of Fanconi's Syndrome Induced by Adefovir in Hepatitis Type B Patient].
Topics: Adenine; Aged; Antiviral Agents; Fanconi Syndrome; Female; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates | 2016 |
Management of individuals with chronic hepatitis B virus infection and persistent normal or mildly elevated aminotransferase levels.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biopsy; Disease Management; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Organophosphonates; Retrospective Studies | 2019 |
Longitudinal trends in renal function in chronic hepatitis B patients receiving oral antiviral treatment.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Longitudinal Studies; Male; Middle Aged; Nutrition Surveys; Organophosphonates; Retrospective Studies; Tenofovir | 2018 |
Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia.
Topics: Adenine; Animals; Apoptosis; Caspases; Cell Cycle Checkpoints; Cytarabine; DNA Damage; Drug Compounding; Drug Resistance, Neoplasm; Drug Synergism; Female; Histones; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Organophosphonates; Poly(ADP-ribose) Polymerases; Transplantation, Heterologous; Tumor Cells, Cultured | 2018 |
Very late onset post-transplant diffuse large B cell lymphoma in a liver transplant recipient with hepatitis B: A case report.
Topics: Adenine; Antiviral Agents; Biopsy, Fine-Needle; Chemoradiotherapy; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Liver Transplantation; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Organophosphonates; Tomography, X-Ray Computed; Treatment Outcome; Virus Replication | 2018 |
Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Leukocytes, Mononuclear; Male; Methylation; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Sustained Virologic Response | 2018 |
Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study.
Topics: Adenine; Administration, Oral; Aged; Antiviral Agents; DNA, Mitochondrial; Female; Gene Deletion; Hepatitis B, Chronic; Humans; Lamivudine; Mitochondrial Myopathies; Muscle, Skeletal; Organophosphonates | 2019 |
Adefovir accumulation and nephrotoxicity in renal interstitium: Role of organic anion transporters of kidney.
Topics: Adenine; Animals; Antiviral Agents; Kidney Diseases; Kidney Tubules; Organic Anion Transporters; Organophosphonates; Rats; Rats, Wistar; Tissue Distribution | 2019 |
Entecavir and Low Genetic Barrier Antiviral Agents for Hepatocellular Carcinoma in Hepatitis B Viral Cirrhosis: Propensity Score Matching.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; China; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Telbivudine | 2019 |
[Marked improvement in renal tubular markers after switching from adefovir to tenofovir alafenamide in a case of Fanconi syndrome diagnosed through high ALP levels].
Topics: Adenine; Alanine; Alkaline Phosphatase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Fanconi Syndrome; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Tenofovir; Tomography, X-Ray Computed; Treatment Outcome | 2019 |
Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Chemical and Drug Induced Liver Injury; Female; Glomerular Filtration Rate; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Male; Middle Aged; Nucleotides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome | 2020 |
Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa-2a.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; ROC Curve; Seroconversion; Young Adult | 2019 |
Fibrosing Cholestatic Hepatitis-Like Syndrome in an Immunocompetent Patient With an Acute Flare of Chronic Hepatitis B.
Topics: Adenine; Biopsy, Needle; Cholestasis; Disease Progression; Follow-Up Studies; Hepatitis B, Chronic; Humans; Immunocompetence; Immunohistochemistry; Liver Cirrhosis; Liver Failure, Acute; Liver Function Tests; Male; Middle Aged; Organophosphonates; Severity of Illness Index; Syndrome; Telbivudine | 2019 |
Synthesis, pharmacological evaluation, and mechanistic study of adefovir mixed phosphonate derivatives bearing cholic acid and l-amino acid moieties for the treatment of HBV.
Topics: Adenine; Antiviral Agents; Cholic Acid; Hepatitis B virus; Humans; Organophosphonates | 2019 |
Quantification of adefovir and pitavastatin in human plasma and urine by LC-MS/MS: A useful tool for drug-drug interaction studies.
Topics: Adenine; Chromatography, High Pressure Liquid; Humans; Organophosphonates; Plasma; Quinolines; Tandem Mass Spectrometry | 2019 |
Effect of nucleos(t)ide analogue on serum HBsAg level in chronic hepatitis B patients: A 3-years study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Nucleotidases; Organophosphonates; Viral Load | 2020 |
Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Beijing; Cohort Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Mutation; Organophosphonates; Prevalence | 2020 |
Is tenofovir and entecavir combination therapy still the optimal treatment for chronic hepatitis B patients with prior suboptimal response?
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Telbivudine; Tenofovir | 2020 |
An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Mutation; Organophosphonates | 2020 |
Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir; Viral Load; Virus Replication | 2021 |
Investigation of multidrug-resistance mutations of hepatitis B virus (HBV) in a large cohort of chronic HBV-infected patients with treatment of nucleoside/nucleotide analogs.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Longitudinal Studies; Male; Middle Aged; Mutation; Nucleosides; Nucleotides; Organophosphonates; Phylogeny; Telbivudine; Viral Load; Virus Replication | 2021 |
[Adefovir-induced osteomalacia and hypophosphatemia].
Topics: Adenine; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia | 2022 |
CKD in a Patient Treated with Adefovir for Chronic Hepatitis B Virus Infection.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates; Renal Insufficiency, Chronic | 2021 |