adenine has been researched along with adefovir dipivoxil in 603 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 34 (5.64) | 18.2507 |
| 2000's | 304 (50.41) | 29.6817 |
| 2010's | 253 (41.96) | 24.3611 |
| 2020's | 12 (1.99) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Cundy, KC; Fishback, JA; Lee, ML; Lee, WA; Shaw, JP; Soike, KF; Visor, GC | 1 |
| Franková, D; Holý, A; Otová, B; Zídek, A | 1 |
| Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L | 1 |
| Andrei, G; De Clercq, E; Snoeck, R | 1 |
| Annaert, P; Augustijns, P; de Clercq, E; Kinget, R; Naesens, L | 1 |
| Barditch-Crovo, P; Cundy, KC; Ebeling, D; Hendrix, CW; Jaffe, HS; Lietman, PS; Toole, J | 1 |
| Boubelík, M; Dráber, P; Franková, D; Holý, A; Zídek, Z | 1 |
| Cherrington, JM; Collier, A; Deeks, SG; Drew, WL; Hellmann, N; Jaffe, HS; Kahn, J; Lalezari, J; Lamy, PD; Li, W; Mulato, AS; Pavia, A; Rodrigue, D; Toole, J | 1 |
| Hino, O; Kajino, K; Kamiya, N; Sakurai, J; Takahara, T; Yamamura, Ki; Yuasa, S | 1 |
| De Clercq, E; Neyts, J | 1 |
| Cundy, KC; Lee, WA; Marshburn, J; Nakamura, C; Shaw, JP; Sue, IL; Visor, GC | 1 |
| Annaert, P; Augustijns, P; Benzaria, S; de Clercq, E; Gosselin, G; Hatse, S; Imbach, JL; Kinget, R; Naesens, L; Pompon, A; Valette, G; Van den Mooter, G | 1 |
| Anton, KE; Cherrington, JM; Hellmann, NS; Lamy, PD; Li, WX; Miller, MD; Mulato, AS | 1 |
| De Clercq, E | 4 |
| Cherrington, JM; Cihlar, T; Fuller, MD; Lamy, PD; Margot, NA; Miller, MD; Mulato, AS | 1 |
| Annaert, P; Augustijns, P; De Clercq, E; Kinget, R; Naesens, L; Van den Mooter, G; Van Gelder, J | 1 |
| Balzarini, J; De Clercq, E; Hatse, S | 1 |
| Anton, KE; Cherrington, JM; Lamy, PD; Miller, MD; Mulato, AS | 1 |
| Gibbs, CS; Rooney, JF; Toole, JJ; Tsiang, M | 1 |
| Baggett, TH; Gracia Jones, S | 1 |
| Franková, D; Holý, A; Zídek, Z | 1 |
| Goa, KL; Noble, S | 1 |
| Crowe, S | 1 |
| Chopra, KB; Gilson, RJ; Jaffe, HS; Murray-Lyon, IM; Nelson, MR; Newell, AM; Rice, SJ; Tedder, RS; Toole, J; Weller, IV | 1 |
| Angarano, G | 1 |
| Gibbs, CS; Howard, T; Jacobsmeyer, S; Lamy, P; Murray, A; Peters, MG; Singer, G; Xiong, X | 1 |
| Blanchard, S; Burchett, S; Coakley, DF; Culnane, M; Cundy, KC; Fridland, A; Hughes, WT; Purdue, L; Read, JS; Rodman, JH; Shenep, JL; Willoughby, R; Zimmer, B | 1 |
| Brosgart, CL; Israelski, DM; Katzenstein, DA; Miller, MD; Murlidharan, U; Passaro, DJ; Shafer, RW; Shulman, NS; Van Doren, S; Zolopa, AR | 1 |
| Gutfreund, K; Hirsch, K; Lamy, P; Murray, A; Perrillo, R; Schiff, E; Statler, A; Wright, T; Yoshida, E | 1 |
| Annaert, P; Augustijns, P; de Clercq, E; Kinget, R; Naesens, L; Tukker, JJ; van Den Mooter, G; van Gelder, J | 1 |
| Leung, N | 1 |
| Hoffman, VF; Skiest, DJ | 1 |
| Boyle, BA | 1 |
| Dahl, TC; Oliyai, R; Yuan, LC | 1 |
| Lagakos, SW; Weinberg, JM | 1 |
| Grande Santamaría, L; Romero Gómez, M; Suárez García, E | 1 |
| Cadman, J | 1 |
| Lau, GK | 1 |
| Alexander, GJ; Bloor, S; Lamy, P; Walsh, KM; Wight, DG; Woodall, T | 1 |
| Benhamou, Y; Bochet, M; Brosgart, C; Calvez, V; Fievet, MH; Fry, J; Gibbs, CS; Katlama, C; Namini, H; Poynard, T; Thibault, V; Vig, P | 1 |
| Brown, C; Cullen, JM; Cundy, KC; Eisenberg, EJ; Gibbs, C; Li, DH; Toole, J; Wolfe, J | 1 |
| Ramrakhiani, S; Sponseller, CA | 1 |
| Perrillo, RP | 2 |
| Benhamou, Y; Bochet, MV; Bombled, T; Calvez, V; Delaugerre, C; Katlama, C; Marcelin, AG; Peytavin, G; Thibault, V | 1 |
| Julander, JG; Morrey, JD; Sidwell, RW | 1 |
| Bendele, RA; Richardson, FC | 1 |
| Aberg, JA; Bennett, KK; Bessen, LJ; Brosgart, C; DeGruttola, V; Eron, JJ; Gulick, RM; Hammer, SM; Holohan, MK; Karol, CN; Lewis, RH; Mellors, JW; Mitsuyasu, RT; Rogers, MD; Saah, AJ; Sheiner, L; Vaida, F; Valentine, FT; Wheat, LJ | 1 |
| Brosgart, C; Delaney, WE; Fry, J; Gibbs, CS; Heathcote, EJ; Ho, V; Miller, MD; Westland, CE; Xiong, S; Yang, H | 1 |
| Dusak, BA; Goodwin, SD; Kuritzkes, DR; Rooney, JF; Skowron, G; Squires, KE; Stevens, M; Thompson, MA; Tolson, JM; Yuen, GJ | 1 |
| Lok, AS | 2 |
| Terrault, NA | 1 |
| McClellan, MB | 1 |
| Zoulim, F | 3 |
| Marcellin, P | 1 |
| Fisher, DA; Huffam, SE | 1 |
| Boarino, V; Gelmini, R; Grottola, A; Lama, NG; Villa, E | 1 |
| Barg-Hock, H; Becker, T; Bleck, JS; Bock, CT; Böker, KH; Flemming, P; Klempnauer, J; Manns, MP; Rosenau, J; Tillmann, HL; Trautwein, C | 1 |
| Brosgart, CL; Chang, TT; Fry, J; Goodman, Z; Hadziyannis, SJ; Heathcote, EJ; Kitis, G; Lim, SG; Marcellin, P; Rizzetto, M; Tassopoulos, NC; Wulfsohn, MS; Xiong, S | 1 |
| Brosgart, CL; Chang, TT; Fry, J; Goodman, Z; Jeffers, L; Lim, SG; Marcellin, P; Shiffman, ML; Sievert, W; Tong, MJ; Wulfsohn, MS; Xiong, S | 1 |
| Gollan, JL; Mailliard, ME | 1 |
| Burroughs, AK; Papatheodoridis, GV; Sevastianos, V | 1 |
| Kern, ER | 1 |
| Hadziyannis, SJ; Papatheodoridis, GV; Vassilopoulos, D | 1 |
| Benhamou, Y; Bernard-Chabert, B; Poynard, T; Ratziu, V; Thabut, D; Thibault, V | 1 |
| Buti, M; Esteban, R | 1 |
| Abbott, B; Bendele, R; Biesecker, G; Desjardins, J; Karimi, S; Meyer, D; Richardson, F | 1 |
| Chen, XY; Yang, HY; Zhang, Y; Zhao, LY; Zhong, DF | 1 |
| Mukherjee, S | 1 |
| Brosgart, CL; Delaney, WE; Fry, J; Gibbs, CS; Miller, MD; Westland, CE; Wulfsohn, M; Xiong, S; Yang, H | 1 |
| Brosgart, C; Chen, SS; Delaney, W; Fry, J; Gibbs, C; Gish, R; Hadziyannis, S; Marcellin, P; Miller, M; Westland, C; Xiong, S; Yang, H | 1 |
| Vere Hodge, A | 1 |
| Angus, P; Ayres, A; Bartholomeusz, A; Brosgart, C; Colledge, D; Delaney, W; Edwards, R; Gibbs, C; Locarnini, S; Vaughan, R; Xiong, S; Yang, H | 1 |
| Ortleb, J | 1 |
| Barcena Marugan, R; Cid Gomez, L; Lopez Serrano, P | 1 |
| Rosenthal, P | 1 |
| Dando, T; Plosker, G | 1 |
| Keeffe, EB; Yu, AS | 1 |
| Sablon, E; Shapiro, F; Zoulim, F | 1 |
| Balistreri, WF; Hochman, JA | 1 |
| Cho, YK; Kim, BI | 1 |
| Brosgart, CL; Choy, GS; Colombo, M; Fry, J; Hadziyannis, S; James, C; Lai, CL; Lama, N; Lilly, L; Namini, H; Neuhaus, P; Rendina, M; Samuel, D; Schiff, ER; Terrault, N; Tillmann, HL; Van Doren, S; Villeneuve, JP; Westland, C; Wulfsohn, MS; Xiong, S; Zeuzem, S | 1 |
| Aloman, C; Wands, JR | 1 |
| Dixon, JS; Humphries, JC | 1 |
| Lai, CL; Poynard, T; Ratziu, V; Yuen, MF | 1 |
| Bourne, E; Brosgart, CL; Gardner, S; Hann, HW; Lee, WM; Leung, N; Moorat, A; Mutimer, D; Perrillo, R; Schiff, E; Willems, B; Woessner, M | 1 |
| Bourliere, M; Brosgart, CL; Buggisch, P; Ebrahimi, R; Gray Df, Df; Hann Hw, Hw; Heathcote, EJ; Kleber, K; Kowdley, K; Martin, P; Peters, MG; Rubin, R; Sullivan, M; Trepo, C; Xiong, S | 1 |
| Dusheiko, G | 1 |
| Benhamou, Y; Poynard, T | 1 |
| Buti, M | 2 |
| Bagnis, CI; Beaufils, H; Benhamou, Y; Brosgart, C; Deray, G; Hannon, H; Izzedine, H; Poynard, T; Sullivan, M | 1 |
| Cinquin, K; Marcellin, P; Maynard, M; Pol, S; Trépo, C; Werle, B; Zoulim, F | 1 |
| Mattes, KA; Qaqish, RB; Ritchie, DJ | 1 |
| Beckebaum, S; Broelsch, CE; Cicinnati, VR; Dirsch, O; Gerken, G; Lama, N; Lampertico, P; Malagó, M; Treichel, U; Trippler, M | 1 |
| Bassett, R; Currier, JS; DeGruttola, V; Demeter, LM; Eron, JJ; Fischl, MA; Hammer, SM; Mellors, JW; Morse, GD; Santana, JL; Squires, KE | 1 |
| Bendayan, R; Dallas, S; Schlichter, L | 1 |
| Apollonio, L; Caldato, M; Fumo, E; Perin, A; Pirisi, M; Toniutto, P | 1 |
| Bergson, P; Gibbs, CS; Shen, Y; Soelaiman, S; Tang, WJ; Wang, CR; Zhukovskaya, NL; Zimmer, MI | 1 |
| Rivkin, AM | 1 |
| Flemming, P; Klempnauer, J; Manns, MP; Nashan, B; Niemann, P; Rohde, P; Tillmann, HL; Tischendorf, JJ; Trautwein, C; Wiegand, J | 1 |
| Cheung, ST; Fan, ST; Lai, CL; Liu, CL; Lo, CM; Ng, IO | 1 |
| Thio, CL | 2 |
| Hino, T; Ide, T; Inoue, H; Koga, Y; Kumashiro, R; Kuwahara, R; Sata, M; Tanabe, R; Tanaka, E | 1 |
| Husa, P | 1 |
| Stránský, J | 1 |
| Iyer, RP; Jin, Y; Korba, B; Morrey, JD; Mounir, S; Roland, A | 1 |
| Avci, A; Erhardt, A; Häussinger, D; Heintges, T; Lörke, J; Sagir, A | 1 |
| Kanemasa, K; Maekawa, K; Minami, M; Mori, K; Okanoue, T; Sumida, Y; Tachibana, S | 1 |
| Bowden, S; Brosgart, CL; Chen, SS; Delaney, WE; Gibbs, CS; Goodman, Z; Lau, G; Locarnini, S; Marcellin, P; Petersen, J; Trepo, C; Werle-Lapostolle, B; Wursthorn, K; Xiong, S; Zoulim, F | 1 |
| Locarnini, S | 1 |
| Perelson, AS; Ribeiro, RM | 1 |
| Tong, MJ; Tu, SS | 1 |
| Cooksley, WG | 1 |
| Samuel, D | 1 |
| Tsai, NC | 1 |
| Avci, IY; Bozdayi, AM; Eyigun, CP; Pahsa, A; Turkyilmaz, AR; Yurdaydin, C | 1 |
| Cote, PJ; Delaney, WE; Gerin, JL; Jacob, JR; Korba, BE; Tennant, BC; Toshkov, I | 1 |
| Enomoto, M; Hino, M; Nishiguchi, S; Seki, S; Yamane, T | 1 |
| Lim, YS; Suh, DJ | 1 |
| Lau, DT; Membreno, FE | 1 |
| Benhamou, Y; Bonyhay, L | 1 |
| Lai, CJ; Terrault, NA | 1 |
| Arterbrun, S; Brosgart, CL; Currie, G; Deray, G; Hadziyannis, SJ; Hulot, JS; Izzedine, H; Launay-Vacher, V; Marcellini, P; Westland, C | 1 |
| Carreño, N; Moreno, D; Sangro, B | 1 |
| Minami, M; Okanoue, T | 1 |
| de Gottardi, A; Negro, F | 1 |
| Fung, SK; Lok, AS | 1 |
| Karayiannis, P | 1 |
| De Medina, M; Madariaga, J; Montalbano, M; Neff, GW; Nery, C; Nery, J; O'brien, CB; Ruiz, P; Safdar, K; Schiff, ER; Shire, N; Tzakis, AG | 1 |
| Lai, CL; Yuen, MF | 2 |
| Danta, M; Dusheiko, G | 1 |
| Da Costa, M; Dan, YY; Isaac, J; Lee, HL; Lee, KH; Lee, YM; Lim, SG; Mak, K; Prabhakaran, K; Sutedja, DS; Wai, CT; Wee, A | 1 |
| Akuta, N; Arase, Y; Hosaka, T; Ikeda, K; Kobayashi, M; Kumada, H; Saitoh, S; Sezaki, H; Someya, T; Suzuki, F; Suzuki, Y; Tsubota, A | 1 |
| Hadziyannis, SJ; Papatheodoridis, GV | 1 |
| Vilde, JL | 1 |
| Blum, HE; Burda, MR; Dandri, M; Gocht, A; Köck, J; Matschl, U; Petersen, J; Pollok, JM; Rogiers, X; von Weizsäcker, F; Wursthorn, K; Zuckerman, DM | 1 |
| Erion, MD; Hong, Z; Lin, CC; Vitarella, D; Yeh, LT | 1 |
| Brosgart, CL; Delaney, WE; Fry, J; Gibbs, CS; Lama, N; Miller, MD; Schiff, ER; Westland, CE; Wulfsohn, M; Xiong, S; Yang, H | 1 |
| González-Carro, P; Pérez-Roldán, F; Villafáñez-García, MC | 1 |
| Chevallier, M; Chevallier, P; Durantel, S; Lot, M; Maynard, M; Parvaz, P; Trepo, C; Zoulim, F | 1 |
| Jiang, Y; Xu, Z; Zhang, X | 1 |
| Eugenidis, N; Giouleme, O; Gkisakis, D; Grammatikos, N; Katsinelos, P; Nikolaidis, N; Orfanou-Koumerkeridou, E; Patsiaoura, K; Theodoropoulos, K; Tziomalos, K; Vassiliadis, T; Zezos, P | 1 |
| Ahn, CS; Ha, TY; Hwang, S; Kim, KH; Kim, KK; Lee, SG; Moon, DB | 1 |
| Chen, Z | 1 |
| Carenzi, S; Colombo, M; Franchello, A; Lampertico, P; Marzano, A; Mazzaferro, V; Pulvirenti, A; Rizzetto, M; Romito, R; Salizzoni, M; Vigano, M | 1 |
| Ceballos, M; Diaz, F; Garcia, A; Garcia, T; González, P; Mazuecos, A; Rivero, M | 1 |
| Barrios Peinado, C; Cuervas-Mons Martínez, V; Herreros de Tejada Echanojáuregui, A; López Monclús, J; Lucena de la Poza, JL; Moreno Planas, JM; Portero Azorin, F; Revilla Negro, J; Rubio González, E; Sánchez Turrión, V | 1 |
| Chan, SC; Fan, ST; Lau, GK; Liu, CL; Lo, CM; Ng, IO | 1 |
| Baker, DE | 1 |
| Choi, MS; Koh, KC; Lee, JH; Moon, W; Moon, YM; Paik, SW; Rhee, JC; Shim, SG; Yoo, BC | 1 |
| Arterburn, S; Brosgart, CL; Chang, TT; Currie, G; Goodman, Z; Hadziyannis, SJ; Heathcote, EJ; Kitis, G; Lim, SG; Ma, J; Marcellin, P; Rizzetto, M; Tassopoulos, NC; Xiong, S | 1 |
| Cheng, AK; Ebrahimi, R; Kearney, BP; Ramanathan, S; Shah, J | 1 |
| Hou, JL; Sun, J | 1 |
| Bian, JS; Boelsterli, UA; Chan, E; Chan, SY; Duan, W; Ho, PC; Huang, M; Li, X; Tan, TM; Tian, Q; Xiong, W; Yang, H; Zhang, J; Zhou, S; Zhu, YZ | 1 |
| Su, GG; Ying, MF; Zhao, NF; Zhou, Y | 1 |
| Choi, WB; Chung, YH; Kim, KM; Lee, HC; Lee, YS; Lim, YS; Suh, DJ | 1 |
| Angarano, G; Fazio, V; Palumbo, E; Saracino, A; Scotto, G; Tartaglia, A | 1 |
| Benhamou, Y; Biao, L; Brosgart, C; Calvez, V; Chang, CG; Currie, G; Fievet, MH; Marcelin, AG; Poynard, T; Thibault, V; Vig, P; Xiong, S | 1 |
| Brosgart, C; Chaix, ML; Currie, G; Fontaine, H; Morales, E; Nalpas, B; Pol, S; Serpaggi, J; Vallet-Pichard, A; Varaut, A; Verkarre, V | 1 |
| Baliellas, C; Cañas, C; Casanovas, A; Casanovas, T; Chahri, N; Figueras, J; Gil-Vernet, S; Gornals, JB; Sabidó, M; Serrano, T; Verdura, B | 1 |
| Avilés, JF; Bárcena, R; Barrios, C; Buti, M; Casanovas, T; Cuervas, V; De la Mata, M; Del Campo, S; Delgado, M; Dieguez, ML; Fraga, E; Gonzalez, A; Herrero, JI; Loinaz, C; Mas, A; Moraleda, G; Moreno, JM; Muñoz, R; Otero, A; Prieto, M; Rueda, M; Sousa, JM | 1 |
| Fan, XP; Guo, RC; Sun, DQ; Wang, BJ; Wang, HS; Wang, K | 1 |
| Aguilar, J; Buti, M; Calleja, JL; Casado, MA; Esteban, R; Rueda, M; Salmerón, J | 1 |
| Mateos, ML; Moreira, V; Tato, M | 1 |
| Byun, KS; Chang, YJ; Chung, HJ; Hong, SP; Kim, JH; Kim, SO; Lee, CH; Moon, MS; Seo, YS; Yeon, JE; Yoo, W; Yu, SK | 1 |
| Amato, A; Gaeta, GB; Stornaiuolo, G | 1 |
| Lai, V; Mirza, D; Mutimer, D; Zhang, WX | 1 |
| Asselah, T; Boyer, N; Marcellin, P | 1 |
| Sherman, M | 1 |
| Holý, A; Kmonícková, E; Zídek, Z | 1 |
| Montazeri, G | 1 |
| Mohamadnejad, M | 1 |
| Kakizaki, S; Mori, M; Sato, K; Sohara, N; Takagi, H | 1 |
| Chung, YH; Jung, SW; Kim, KM; Kim, SO; Lee, HC; Lee, YS; Lim, YS; Suh, DJ; Yoo, W | 1 |
| Chen, W; Li, G; Li, L; Lu, JX; Xie, DY; Xu, QH; Zhu, MF | 1 |
| Feng, B; Wei, L | 1 |
| Hou, JL; Zeng, GB | 1 |
| Kondo, S; Kondo, Y | 1 |
| Borlang, J; Giles, E; Heathcote, EJ; Osiowy, C; Villeneuve, JP | 1 |
| Kumada, H; Nakamura, H; Suzuki, F | 1 |
| Zhuang, H | 1 |
| Brown, NA; Chao, GC; Fielman, BA; Lloyd, DM; Zhou, XJ | 1 |
| Eun, JR | 1 |
| Lee, WA; Martin, JC | 1 |
| Guo, RC; Ni, MY; Sun, DQ; Wang, BJ; Wang, HS | 1 |
| Hollinger, FB; Lau, DT | 1 |
| Grattagliano, I; Palasciano, G; Palmieri, VO; Portincasa, P | 1 |
| Davidson, P; Jones, J; Price, A; Shepherd, J; Takeda, A | 2 |
| Müller, C | 1 |
| Buggisch, P; Lutgehetmann, M; Petersen, J; Wursthorn, K; Zollner, B | 1 |
| Alston-Smith, B; Andersen, J; Brosgart, CL; Jacobson, JM; Johnson, VA; Liu, T; Lynch, P; Peters, MG; Pollard, RB; Polsky, B; Rooney, JF; Sherman, KE; Swindells, S | 1 |
| Baik, du S; Kim, BH; Kim, HJ; Kim, SB; Seo, PJ; Shin, JE; Song, IH; Yun, SY | 1 |
| Arterburn, S; Borroto-Esoda, K; Brosgart, CL; Chang, TT; Chuck, SL; Goodman, Z; Hadziyannis, SJ; Heathcote, EJ; Kitis, G; Lim, SG; Ma, J; Marcellin, P; Rizzetto, M; Tassopoulos, NC | 1 |
| Dassanayake, AS; de Silva, AP; de Silva, HJ; Manamperi, A | 1 |
| Chen, YK; Lei, BJ; Lu, ZM; Wang, YM; Yin, YK; Yu, YS; Zhang, DZ | 1 |
| Anzenbacher, P; Anzenbacherová, E; Holý, A; Matal, J; Nekvindová, J; Orság, J; Veinlichová, A; Zídek, Z | 1 |
| Anzenbacher, P; Anzenbacherová, E; Holý, A; Masek, V; Nekvindová, J; Veinlichová, A; Zídek, Z | 1 |
| Janssen, HL; Kuipers, EJ; Kusters, JG; Stoop, JN; van der Molen, RG | 1 |
| Chen, XY; Kang, XP; Li, J; Lin, XH; Liu, P; Ren, XM; Si, CW; Yu, YY; Zhang, SL | 1 |
| Chung, YH; Ryu, SH | 1 |
| Cho, YS; Kim, DH; Kim, DY; Kim, HJ; Lee, CK; Park, BK; Park, IS; Suh, JH; Won, SY | 1 |
| Huang, YX; Mao, RC; Qin, YL; Weng, XH; Wu, XH; Yin, YK; Zhang, JM; Zhang, QB; Zhang, WQ | 1 |
| Dimou, E; Hadziyannis, SJ; Mitsoula, P; Rapti, I | 1 |
| Aubourg, A; Bacq, Y; d'Alteroche, L; Gaudy, C; Senecal, D | 1 |
| Locarnini, SL; Macdonald, G; Sasadeusz, JJ | 1 |
| Changchien, CS; Chen, CH; Hu, TH; Hung, CH; Lee, CM; Lu, SN; Wang, JC; Wang, JH | 1 |
| Lok, AS; Tan, J | 1 |
| Bouvier-Alias, M; Brillet, R; Chevaliez, S; Dhumeaux, D; Hézode, C; Pawlotsky, JM; Roudot-Thoraval, F; Zafrani, ES | 1 |
| Arterburn, S; Borroto-Esoda, K; Brosgart, C; Chuck, S; Colombo, M; Hadziyannis, S; Lai, CL; Neuhaus, P; Samuel, D; Schiff, E; Terrault, N; Tillmann, H; Villeneuve, JP; Zeuzem, S | 1 |
| Delaney, WE | 1 |
| Gish, RG | 1 |
| Berger, A; Faust, D; Stuermer, M; Teuber, G; Trojan, J | 1 |
| Chang, WY; Chen, SC; Chuang, WL; Dai, CY; Hou, NJ; Hsieh, MY; Huang, JF; Lee, LP; Lin, ZY; Tsai, JF; Wang, LY; Yu, ML | 1 |
| Chan, HL; Chan, HY; Chim, AM; Sung, JJ; Tse, CH; Wong, GL; Wong, VW | 1 |
| Akarca, U; Akyildiz, M; Batur, Y; Ersoz, G; Gunsar, F; Ilter, T; Karasu, Z | 1 |
| Koike, K; Yotsuyanagi, H | 2 |
| Fung, J; Lai, CL; Mizokami, M; Tanaka, Y; Wong, DK; Yuen, JC; Yuen, MF | 1 |
| Bae, SH; Chang, UI; Choi, JY; Jang, JW; Lee, YC; Sun, HS; Wie, SH; Yang, JM; Yoon, SK | 1 |
| Ling, N; Ren, H; Zhang, DZ; Zhou, Z | 1 |
| Akuta, N; Arase, Y; Hosaka, T; Ikeda, K; Kobayashi, M; Kumada, H; Saitoh, S; Sezaki, H; Someya, T; Suzuki, F; Suzuki, Y | 1 |
| Palumbo, E | 1 |
| Delaney, WE; Miller, M; Qi, X; Xiong, S; Yang, H | 1 |
| Chen, XY; Si, CW; Tang, XP; Wang, L; Zhang, YX; Zhao, H | 1 |
| Arterburn, S; Borroto-Esoda, K; Miller, MD | 1 |
| Bak, YT; Byun, KS; Kim, JH; Kim, JS; Lee, CH; Park, JJ; Seo, YS; Yeon, JE | 1 |
| Anderson, J; Bowden, S; Cooksley, H; Hui, CK; Lau, GK; Lewin, S; Locornini, S; Mondou, E; Naoumov, NV; Perelson, AS; Powers, KA; Ribeiro, RM; Rousseau, F; Shudo, E; Sorbel, J | 1 |
| Bozdayi, AM; Karaaslan, H; Karatayli, E; Karayalçin, S; Kayhan, H; Sahin, F; Türkyilmaz, AR; Yurdaydin, C | 1 |
| Jiang, Y; Liu, FH | 1 |
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| Huang, L; Li, T; Wang, C; Xu, D; Zhao, P | 1 |
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| Cheng, D; Gong, GZ; He, B; Jiang, YF; Li, NP; Ma, J | 1 |
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| Ding, SX; Hu, AR; Hu, YR; Jiang, SW; Li, L; Liang, XY | 1 |
| Ahn, SH; Hong, SP; Hwang, SG; Kim, BH; Kim, HS; Kim, IH; Kim, JH; Lee, JI; Lee, JM; Lee, JW; Lee, SH; Lee, SJ; Park, SJ; Park, YM; Seo, YS; Yim, HJ; Yoon, EL | 1 |
| Feng, XM; Huang, SM; Li, AY; Wang, BJ; Wang, JZ; Yang, DL; Zhu, B; Zhu, ZN | 1 |
| Miao, QL; Zhao, KK; Zhao, Y | 1 |
| Hirayama, K; Kobayashi, M; Ogawa, Y; Sakai, S; Shimohata, H | 1 |
| Chan, JC; Chen, S; Chu, TT; Fok, BS; Gardner, S; Piscitelli, S; Tomlinson, B | 1 |
| Wang, H; Yang, J; Zhu, X | 1 |
| Berg, T; Borroto-Esoda, K; Curtis, M; Kitrinos, KM; Lavocat, F; Miller, MD; Svarovskaia, ES; Zhu, Y; Zoulim, F | 1 |
| Amini-Bavil-Olyaee, S; Herbers, U; Luedde, T; Mueller, A; Tacke, F; Trautwein, C | 1 |
| An, H; Chun, HJ; Jeen, YT; Jung, JY; Keum, B; Kim, CD; Kim, CH; Kim, JD; Kim, YS; Lee, HS; Ryu, HS; Seo, YS; Um, SH; Yim, HJ; Yun, TJ | 1 |
| Dinh, P; Flaherty, JF; Gordon, SC; Horban, A; Kitrinos, KM; Krastev, Z; Marcellin, P; Martins, EB; Petersen, J; Rustgi, VK; Sperl, J; Yee, LJ | 1 |
| Chen, JJ; Chen, ZT; Gan, JH; Li, Y; Luo, EP; Wu, JC; Zhao, WF | 1 |
| Chen, EQ; Liu, K; Lu, JJ; Ma, YJ; Tang, H; Wang, J | 1 |
| Bai, XF; Li, Y; Lian, JQ; Wang, JP; Zhang, Y | 1 |
| Özenirler, S; Sucak, GT; Suyanı, E; Yaşar, DG | 1 |
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| Chen, CW; Gu, EL; Ji, YY; Li, J; Ma, XY; Pang, HY; Wang, H; Wu, SM; Xie, Q; Xu, XW; Yao, GB | 1 |
| Lou, GQ; Lu, L; Qian, JC; Shi, JP; Yan, FL; Zhu, MF | 1 |
| Dai, Z; Gu, X; Qian, Y; Wang, L; Wu, C; Zhang, H | 1 |
| Ahn, SH; Baartarkhuu, O; Chon, CY; Han, KH; Kim, BK; Kim, DY; Kim, JK; Kim, KS; Kim, SU; Park, JY; Park, MS | 1 |
| Huang, XX; Lou, GQ; Shi, JP; Wang, J; Wu, J; Zhu, MF | 1 |
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| Chen, Y; Li, LJ; Lv, GC; Sheng, JF; Yang, YD; Yao, JM; Zheng, L | 1 |
| Chen, L; Deng, YD; Mao, XR; Yuan, H; Yue, W | 1 |
| Cai, HD; He, YQ; Li, RH; Ma, XY; Tian, JH; Wan, G; Zhang, SF | 1 |
| Chen, Y; Liu, Z | 1 |
| Hu, H; Hu, P; Liu, J; Peng, H; Ren, H; Tang, H; Tong, S; Yang, M; Yin, W | 1 |
| Chen, JY; Hu, JH; Jia, HY; Li, LJ; Lian, JS; Lu, YF; Xiang, DR; Yang, YD; Yu, L; Zeng, LY; Zhang, YM; Zheng, L | 1 |
| Česnek, M; Dvoráková, A; Janeba, Z; Mertlíková-Kaiserová, H; Šmídková, M; Tloust'ová, E | 1 |
| He, Y; Huang, J; Huang, X; Li, L; Li, Y; Lv, Y; Wang, K; Yang, J; Zhang, Y; Zheng, Q | 1 |
| Chen, J; Fan, SY; Li, CK; Li, JL; Liao, S; Liu, Q; Xie, JW; Zhang, ZQ; Zhang, ZW; Zhong, BH | 1 |
| Chen, Z; Li, M; Liu, Z; Wu, J; Xu, G; Zhang, Q | 1 |
| Calvaruso, V; Craxì, A | 1 |
| Deng, Z; Li, B; Li, Z; Liu, S; Wang, C | 1 |
| Eguchi, H; Hiromatsu, Y; Kuwahara, R; Tani, J; Tsuruta, M | 1 |
| Cheng, L; Gao, J; Gao, Y; Kan, H; Luo, L; Ma, K; Su, Q; Zhang, J; Zhang, Y | 1 |
| Falsafi, M; Shahabadi, N | 1 |
| Chen, W; Sun, Q; Xie, FY | 1 |
| Chen, H; Chen, J; Jiang, L; Li, D; Lin, J; Ou, Q; Su, M; Wang, W; Yang, B; Zeng, Y | 1 |
| Anzenbacher, P; Anzenbacherova, E; Contreras, JA; Fon Tacer, K; Juvan, P; Kopecna Zapletalova, M; Nekvindova, J; Rozman, D; Zidek, Z | 1 |
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| Chen, JX; Hu, Y; Mou, LJ; Zhu, LN | 1 |
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| He, CP; Huang, LW; Ling, K; Liu, L; Wang, XM; Wen, QM; Yan, Y; Zhou, HC; Zhou, J | 1 |
| Hu, H; Hu, P; Liu, F; Ren, H; Wang, X; Wei, F; Zhang, D | 1 |
| Chen, L; Li, C; Li, X; Liu, W; Liu, Y; Wang, X; Xin, S; Xu, D; Xu, Z | 1 |
| Chokshi, S; Cooksley, H; Gaggar, A; Naoumov, NV; Phillips, S; Riva, A; Williams, R | 1 |
| Chang, L; Du, Y; Jia, T; Li, H; Li, W; Liu, L; Liu, Y; Peng, D | 1 |
| Chen, J; Chen, LH; Dong, J; Gao, LY; Jiang, JJ; Liu, YR; You, J; Zeng, DW; Zheng, Q; Zhu, YY | 1 |
| Hou, F; Huo, N; Li, F; Li, M; Wang, Q; Xi, H; Xu, X; Zhang, X | 1 |
| Hou, FQ; Huo, N; Li, F; Li, MR; Wang, QH; Xi, HL; Xu, XY; Zhang, XX | 1 |
| Chen, EQ; Shi, Y; Tang, H; Wu, DB | 1 |
| Chan, HL; Chen, R; Li, X; Liu, L; Liu, Y; Wong, VW; Xin, S; Xu, D; Xu, Z; Yang, D; Yang, J | 1 |
| Hasegawa, E; Hiramatsu, R; Hirose, K; Ikeda, K; Kumada, H; Murakami, M; Sawa, N; Takaichi, K; Ubara, Y | 1 |
| Chen, CW; Chen, SJ; Cheng, J; Dong, J; Gao, ZL; Hou, JL; Ji, Y; Jia, JD; Li, J; Mao, Q; Mao, YM; Ning, Q; Niu, JQ; Pan, C; Ren, H; Sheng, JF; Tan, DM; Tang, H; Wang, H; Wu, SM; Xie, Q; Xu, M; Zhang, JM; Zhang, XX; Zhao, W | 1 |
| Li, H; Qiu, L; Xiao, P; Yuan, X; Zhou, Q | 1 |
| Chen, C; Chen, S; Chen, X; Cheng, J; Dou, X; Hou, J; Jia, J; Jiang, J; Li, T; Liang, X; Long, H; Ma, H; Ning, Q; Niu, J; Ren, H; Sheng, J; Shi, G; Shi, J; Sun, J; Sun, Y; Tan, D; Tang, H; Wan, M; Wang, H; Xie, Q; Yu, Y; Zhuang, H | 1 |
| Jiao, Z; Yan, L; Zhang, D | 1 |
| Enomoto, M; Hayakawa, M; Iwadate, M; Kawada, N; Murakami, Y; Tamori, A; Tanahashi, T; Umeyama, H; Yano, Y | 1 |
| Chowdhury, MS; Khan, MR; Mahmuduzzaman, M; Miah, AR; Rahman, KM; Raihan, MA; Roknuzzaman, SM; Roy, PK; Saha, M | 1 |
| Fan, J; Guo, X; Wang, Y; Xiong, H; Zhang, Y | 1 |
| Chen, SX; Ding, SX; Gao, GS; Hu, AR; Hu, YR; Jiang, SW; Liang, XY; Weng, PJ; Xiong, T; Yao, LP | 1 |
| Fan, H; Fan, Y; Ge, Y; Li, D; Liu, X; Liu, Z; Lyu, W; Yang, H; Zhou, B | 1 |
| Bart Takkenberg, R; de Niet, A; Dill, MT; Heim, MH; Jansen, L; Janssen, HL; Kootstra, NA; Makowska, Z; Reesink, HW; Terpstra, V; van Dort, KA | 1 |
| Aschauer, L; Bellwon, P; Bois, F; Crean, D; Dekant, W; Herrgen, K; Hewitt, P; Jennings, P; Leonard, MO; Limonciel, A; Lukas, A; Moenks, K; Schmidt, T; Wilmes, A | 1 |
| Arora, KK; Bhardwaj, SP; Mistry, P; Suryanarayanan, R | 1 |
| Feng, L; Huang, F; Jin, J; Luo, G; Ma, H; Sun, F; Wang, G; Wang, Y; Yang, J; Zhang, J; Zhao, W; Zhao, Z; Zhu, J | 1 |
| Furusyo, N; Harada, Y; Hayashi, J; Hayashi, T; Ihara, T; Ikezaki, H; Murata, M; Ogawa, E; Shimizu, M; Toyoda, K | 1 |
| Chen, YS; Sun, FR; Wang, BF; Wang, BY; Wang, Y; Zhang, D | 1 |
| Ouyang, R; Ye, X | 1 |
| Heathcote, EJ; Ho, EY; Lau, GK; Rousseau, F; Yau, T | 1 |
| Dong, H; Guan, GJ; Jiang, W; Liu, LQ; Liu, T; Liu, XC; Xu, Y | 1 |
| Chi, Y; Jiang, Y; Li, M; Liao, RX; Liu, XQ; Liu, ZY; Mao, JF; Wang, O; Xia, WB; Xing, XP; Xu, LJ; Yu, W; Zhang, HB | 1 |
| Chan, HL; Chan, HY; Lo, AO; Tse, YK; Wong, GL; Wong, VW | 1 |
| Cai, H; Chen, JY; Ding, F; Hu, JH; Jia, HY; Li, LJ; Lian, JS; Lu, YF; Xiang, DR; Yang, YD; Yu, GD; Yu, L; Zeng, LY; Zhang, YM; Zheng, L | 1 |
| Feng, JY; Ji, HF; Jiang, YF; Liu, MY; Ma, L; Wang, J; Yu, L; Zhao, PW | 1 |
| Abreu, RM; Baldassare, RM; Carrilho, FJ; Kim, V; Nakagawa, DM; Ono, SK | 1 |
| Chen, J; Deng, H; Guo, JJ; Huang, A; Huang, WX; Huang, Y; Shan, X; Shan, YL; Tang, N; Wang, YW; Zhang, DZ | 1 |
| Liu, Y; Qiu, P; Wang, G; Wen, J; Wen, P; Xiao, X; Xu, L; Zhou, SF | 1 |
| Chen, G; Chen, X; Jiang, D; Yang, G; Yang, J; Zhang, H | 1 |
| Chen, J; Gong, X; Huang, A; Huang, W; Liang, Z; Shan, X; Shan, Y; Wang, Y; Xu, G; Zen, A; Zhang, D; Zhang, X; Zhao, Y; Zhou, X | 1 |
| Dang, B; Kang, W; Liu, Q; Sun, Y; Wang, C; Yao, N; Yu, Z; Zhao, K | 1 |
| Kim, KT; Lee, JI; Oh, HM; Oh, J | 1 |
| Brust, TF; Česnek, M; Dračínský, M; Janeba, Z; Jansa, P; Mertlíková-Kaiserová, H; Pávek, P; Šmídková, M; Trejtnar, F; Watts, VJ | 1 |
| Cheepala, S; Fatima, S; Fukuda, Y; Jackson, S; Kawauchi, D; Morfouace, M; Patel, YT; Roussel, MF; Schuetz, JD; Shelat, AA; Sorrentino, BP; Stewart, CF | 1 |
| Cai, D; Hu, P; Huang, W; Ren, F; Tang, L; Yuan, X; Zhu, H | 1 |
| Gu, J; Shen, S; Sun, R; Yu, Z | 1 |
| Ding, G; Kang, Y; Li, K; Li, W; Mao, Z; Ning, H; Shang, J; Xiao, E | 1 |
| Chen, JM; Lin, RZ; Lu, TB; Sun, PJ; Tao, Q; Yao, J | 1 |
| Choi, MK; Kim, SB; Maeng, HJ; Son, JH; Yoon, IS | 1 |
| Furusyo, N; Hayashi, J; Murata, M; Ogawa, E; Shimizu, M | 1 |
| Ao, Y; Chen, S; Chong, Y; Gao, Z; Huang, M; Jie, Y; Li, X; Lin, G; Shi, H; Wu, Y; Yang, F; Zhang, M | 1 |
| Dandri, M; Lütgehetmann, M; Murray, JM; Petersen, J; Stancevic, O; Wursthorn, K | 1 |
| An, JH; Jin, F; Jung, K; Kim, HM; Kim, HS; Kim, JS; Kim, KH; Kiyonga, AN; Min, DS; Ryu, HC; Youn, W | 1 |
| Liu, Y; Qiu, P; Wang, GL; Wen, JB; Wen, P; Xiao, XZ; Xu, LF; Zhou, SF | 1 |
| Fei, R; Wang, JH; Wang, XY; Wei, L; Zhang, HY | 1 |
| Cheng, J; Liu, S; Wang, Q; Wang, X; Xing, H; Yang, S | 1 |
| Dan, J; Kim, BK; Lee, HJ; Lee, YS | 1 |
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| Hiraoka, A; Kumada, T; Tada, T; Tanaka, J; Toyoda, H; Tsuji, K | 1 |
| Hirase, S; Ito, K; Ito, T; Morishima, T; Morita, H; Ohashi, T; Otake, K; Takagi, J; Yoneda, M | 1 |
| Bao, ZY; Duan, SH; Liu, MS; Wang, L; Yuan, XD | 1 |
| Akyildiz, M; Balci, D; Cinar, K; Dayangac, M; Gungor, G; Hazinedaroglu, S; Idilman, R; Kalkan, C; Keskin, O; Tokat, Y; Yilmaz, TU | 1 |
| Cao, H; Li, G; Liang, J; Shu, X; Sun, H; Xu, Q; Zhang, K | 1 |
| Buti, M; Cathcart, AL; Corsa, AC; Flaherty, JF; Gane, EJ; Kitrinos, KM; Liu, Y; Marcellin, P; Miller, MD | 1 |
| Fu, WZ; He, JW; Wei, Z; Zhang, ZL | 1 |
| Fan, YC; Han, FZ; Wang, K; Wang, LP; Yan, XB | 1 |
| Cheng, F; Deng, Y; Kang, J; Luo, Q; Zeng, W; Zhang, D; Zhong, S | 1 |
| Dixit, VK; Jain, AK; Nath, G; Singh, N; Srivastava, M | 1 |
| Hong, LJ; Wei, L; Ying, H; Zhang, J | 1 |
| Dolberg, AM; Reichl, S | 1 |
| Hwang, KM; Kim, DW; Lee, SH; Park, ES; Seo, JW | 1 |
| Jansen, L; Janssen, HLA; Peters, MW; Reesink, HW; Stelma, F; Takkenberg, RB; van der Ree, MH; Zaaijer, HL | 1 |
| Chayama, K; Enomoto, H; Enomoto, M; Hino, K; Hiramatsu, N; Ikeda, F; Kagawa, T; Kanda, T; Kang, JH; Kurosaki, M; Matsumoto, A; Mine, T; Miyase, S; Morihara, D; Murata, K; Nagaoka, S; Nishiguchi, S; Okuse, C; Saito, S; Sakisaka, S; Shinkai, N; Suzuki, Y; Takaguchi, K; Tanaka, E; Tanaka, Y; Tsuge, M; Yatsuhashi, H; Yokosuka, O | 1 |
| Abdelbary, GA; Amin, MM; El Awdan, SA; Zakaria, MY | 1 |
| Guo, H; Jiao, J; Liu, Z; Qi, W; Wang, J; Wang, X; Xu, Y; Yu, F; Zhao, P; Zhou, C | 1 |
| Chang, S; Chen, B; Qiu, L; Shen, F; Sun, Y; Wu, K; Yu, L | 1 |
| Han, Z; Huang, M; Liu, J; Shi, H; Xia, J; Xue, J; Zhang, S; Zhu, Z | 1 |
| Blanco, MÁ; Bonet, ML; Calleja, JL; Casado, MÁ; Fraga, E; Fuentes, J; García-Buey, ML; González, JM; Jorquera, F; Molina, E; Pascasio, JM; Pons, JA; Prieto, M; Rodríguez, M; Salmerón, J; Sánchez-Antolín, G | 1 |
| Feng, L; Gao, RW; Li, R; Yang, YH; Zhang, B; Zhu, S; Zou, YZ | 1 |
| Chen, D; Guo, X; Li, Q; Liu, K; Ouyang, Y; Wang, Y; Wei, F; Wu, J; Zhang, Y | 1 |
| Chen, N; Li, LY; Liu, LW; Peng, T; Tang, KX; Yu, F; Yu, X; Zhang, JB; Zhang, Q; Zhao, YP | 1 |
| Huang, AL; Huang, C; Shi, XF; Yang, XH; Yang, YL | 1 |
| Chen, YM; Deng, H; Gao, ZL; Lin, CS; Mei, YY; Peng, L; Xie, C; Xie, DY; Xu, WX; Zhang, Q; Zhao, ZX; Zhu, X | 1 |
| Bao, L; Li, WT; Li, Y; Wang, Y; Xu, J; Yang, L; Zhao, ZH | 1 |
| Iino, N; Koda, R; Narita, I; Tsuchida, M | 1 |
| Chen, EQ; Deng, R; Liao, J; Tang, H; Tao, CM; Wang, J; Wang, ML; Zhou, TY | 1 |
| Nie, ZW; Xu, Y | 1 |
| Li, X; Liang, D; Liang, S; Lv, Y; Xu, F; Zeng, C; Zhu, X | 1 |
| He, L; Li, C; Peng, W; Shen, J; Wen, T; Xia, Z; Zhang, X | 1 |
| He, QY; Hong, P; Hu, HF; Huang, XH; Li, B; Xu, WW; Yan, X; Yang, J; Ye, F; Zhang, QH | 1 |
| Ikeda, A; Ikeda, F; Kanzaki, H; Kitamura, Y; Makita, T; Murakawa, K; Nishihara, S; Okada, H; Onishi, H; Sendo, T; Shiraha, H; Takaki, A; Takeuchi, Y; Tanaka, Y; Wada, N; Yasunaka, T | 1 |
| Aso, Y; Iijima, T; Jojima, T; Kase, M; Kogai, T; Kunii, T; Sakurai, S; Shimizu, M; Usui, I | 1 |
| Bai, X; Cheng, Z; Feng, X; He, F; Liu, H; Qing, Y; Takeda, S; Wu, X; Wu, Y; Xiang, C; Zhao, Z | 1 |
| Akita, T; Kumada, T; Kurisu, A; Miyake, N; Ohisa, M; Tada, T; Tanaka, J; Toyoda, H; Yasuda, S | 1 |
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107 review(s) available for adenine and adefovir dipivoxil
| Article | Year |
|---|---|
Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cidofovir; Cytosine; DNA Virus Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections | 1997 |
Clinical update: new drugs for HIV/AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Chemistry, Pharmaceutical; Cyclopropanes; Dideoxynucleosides; Drug Approval; Furans; HIV Protease Inhibitors; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Sulfonamides | 1999 |
Adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; In Vitro Techniques; Organophosphonates; Placebos; Prodrugs; Reverse Transcriptase Inhibitors | 1999 |
New reverse transcriptase inhibitors.
Topics: Adenine; Alkynes; Benzoxazines; Cyclopropanes; Delavirdine; Dideoxynucleosides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Organophosphonates; Oxazines; Prodrugs; Reverse Transcriptase Inhibitors; Soman; Uracil | 1999 |
Coming therapies: adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple; HIV Infections; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 1999 |
Nucleoside analogues in the treatment of chronic hepatitis B.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Deoxycytidine; Emtricitabine; Famciclovir; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2000 |
Therapeutic developments in cytomegalovirus retinitis.
Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Drugs, Investigational; Foscarnet; Ganciclovir; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valganciclovir | 2000 |
Hepatitis B infection in China.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; China; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Drugs, Chinese Herbal; Emtricitabine; Famciclovir; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Thymosin | 2001 |
Treatment of hepatitis B and C following liver transplantation.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Disease Progression; Drug Resistance; Drug Therapy, Combination; Hepatitis B; Hepatitis C; Humans; Immunoglobulins; Interferon-alpha; Lamivudine; Liver Transplantation; Organophosphonates; Prognosis; Ribavirin; Secondary Prevention; Survival Rate | 2002 |
How will we use the new antiviral agents for hepatitis B?
Topics: 2-Aminopurine; Adenine; Alanine Transaminase; Antiviral Agents; Drug Resistance; Drug Therapy, Combination; Famciclovir; Ganciclovir; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Mutation; Organophosphonates; Practice Guidelines as Topic | 2002 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Clinical Trials as Topic; Drug Industry; Hepatitis B, Chronic; HIV Infections; Humans; Organophosphonates | 2002 |
Prevention of recurrent hepatitis B post-liver transplantation.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Postoperative Complications; Reverse Transcriptase Inhibitors; Secondary Prevention; Viral Hepatitis Vaccines | 2002 |
Assessing hepatitis B virus resistance in vitro and molecular mechanisms of nucleoside resistance.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Humans; In Vitro Techniques; Lamivudine; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Advances in therapy for chronic hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Management of chronic hepatitis B virus infection in remote-dwelling Aboriginals and Torres Strait Islanders: an update for primary healthcare providers.
Topics: Adenine; Adolescent; Adult; Algorithms; Antiviral Agents; Australia; Carcinoma, Hepatocellular; Child; Child, Preschool; Clinical Protocols; Endemic Diseases; Female; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Interferon-alpha; Lamivudine; Liver Neoplasms; Liver Transplantation; Male; Mass Screening; Middle Aged; Native Hawaiian or Other Pacific Islander; Organophosphonates; Primary Health Care; Rural Health Services | 2003 |
Prevention of and treatment for hepatitis B virus infection after liver transplantation in the nucleoside analogues era.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Postoperative Complications; Recurrence; Time Factors; Transplantation Immunology | 2003 |
In vitro activity of potential anti-poxvirus agents.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Mice; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Virus Replication | 2003 |
Treatment of HBeAg-negative chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Endpoint Determination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Inflammation; Interferon-alpha; Lamivudine; Liver Cirrhosis; Organophosphonates; Patient Care Planning; Prognosis; Reverse Transcriptase Inhibitors; Virus Replication | 2003 |
Adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Interactions; Hepatitis B, Chronic; Humans; Organophosphonates; Treatment Outcome | 2003 |
Adefovir dipivoxil: a review of its use in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Organophosphonates | 2003 |
Nucleoside analogues and other antivirals for treatment of hepatitis B in the peritransplant period.
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Preoperative Care; Recurrence; Virus Replication | 2003 |
Early detection of hepatitis B drug resistance: implications for patient management.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2003 |
Chronic viral hepatitis: always be current!
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Child; Female; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Humans; Immunization Schedule; Infant, Newborn; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prevalence; Risk Factors; Serologic Tests; Treatment Outcome; United States; Viral Hepatitis Vaccines | 2003 |
[Application and efficacy of adefovir dipivoxil in hepatitis B virus-associated chronic liver diseases].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Liver Diseases; Organophosphonates | 2003 |
Viral hepatitis B.
Topics: Adenine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Genotype; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Load | 2003 |
Adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B: a review of the major clinical studies.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic | 2003 |
Management of the patient with hepatitis B virus-related cirrhosis.
Topics: Adenine; Antiviral Agents; Hepatitis B; Humans; Interferons; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors | 2003 |
Treatment of chronic hepatitis B virus infection in patients co-infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Adefovir dipivoxil: a new antiviral agent for the treatment of hepatitis B virus infection.
Topics: Adenine; Animals; Antiviral Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2003 |
Adefovir dipivoxil in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Interactions; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; HIV Infections; Humans; Liver Transplantation; Organophosphonates; Randomized Controlled Trials as Topic | 2004 |
Management of chronic hepatitis B in the HIV-infected patient.
Topics: Adenine; Algorithms; Antiviral Agents; Clinical Trials as Topic; Decision Trees; Drug Therapy, Combination; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
[Adefovir dipivoxil is a new drug for treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates | 2004 |
[New approaches in the treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Contraindications; Deoxycytidine; Emtricitabine; Famciclovir; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Organophosphorus Compounds; Polyethylene Glycols; Prodrugs; Prognosis; Recombinant Proteins; Tenofovir; Zalcitabine | 2004 |
Molecular virology of hepatitis B virus.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Transcription, Genetic; Viral Proteins; Virus Replication | 2004 |
Hepatitis B virus kinetics and mathematical modeling.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; Hepatocytes; Lamivudine; Models, Biological; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Load; Virion | 2004 |
Treatment of patients with chronic hepatitis B with adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
Treatment with interferons (including pegylated interferons) in patients with hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2004 |
Management of hepatitis B in liver transplantation patients.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Organophosphonates; Reoperation; Secondary Prevention; Virus Replication | 2004 |
Current antiviral therapy for chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Antiviral therapy for treatment-naïve hepatitis B virus patients.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Treatment of hepatitis B virus infection in patients coinfected with HIV.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Antiviral therapy in patients with chronic hepatitis B and cirrhosis.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Organophosphonates | 2004 |
[Treatment of chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
[Antiviral treatment of chronic hepatitis B with adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
[Management of hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Child; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Infant, Newborn; Interferon-alpha; Lamivudine; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Time Factors | 2004 |
Treatment of chronic hepatitis B: who to treat, what to use, and for how long?
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; DNA Virus Infections; Drug Resistance, Viral; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Tenofovir | 2003 |
Current therapies for chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Drug Resistance; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
Adefovir dipivoxil in chronic hepatitis B infection.
Topics: Adenine; Animals; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2004 |
Adefovir dipivoxil: review of a novel acyclic nucleoside analogue.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Drug Resistance, Viral; Hepatitis B, Chronic; HIV Infections; Humans; Organophosphonates; Treatment Outcome | 2004 |
Emerging treatments in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Combinations; Drug Resistance, Viral; Drug Therapy; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins; Vaccines | 2004 |
[Subjective literature review: adefovir-dipivoxil].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B, Chronic; Humans; Organophosphonates | 2004 |
Adefovir dipivoxil: focus on its use in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2005 |
[New virologic tests and their application in management of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genetic Variation; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Phenotype; Research; Reverse Transcriptase Inhibitors; Viral Load; Virology; Virus Replication | 2006 |
Medical therapy of patients affected by HBeAg-negative chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2006 |
Personal view: the management of chronic hepatitis B infection.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Tenofovir | 2006 |
Current treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Forecasting; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunologic Factors; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleocapsid; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors | 2006 |
Perspectives on the development of acyclic nucleotide analogs as antiviral drugs.
Topics: Adenine; Animals; Antiviral Agents; Dogs; Drug Design; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Nucleotides; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir | 2006 |
Hepatitis B: the pathway to recovery through treatment.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis C, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2006 |
Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Drug Carriers; Drug Therapy, Combination; Health Services; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Patient Selection; Polyethylene Glycols; Quality of Life; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Recombinant Proteins | 2006 |
Chronic Hepatitis B and C--current treatment and future therapeutic prospects.
Topics: Adenine; Antiviral Agents; DNA-Directed RNA Polymerases; Hepatitis B e Antigens; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2006 |
[Resistance to adefovir in patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Treatment Outcome | 2006 |
A systematic review and economic evaluation of adefovir dipivoxil and pegylated interferon-alpha-2a for the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; England; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Wales | 2007 |
Improving outcomes for patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2007 |
[Mechanisms of drug resistance in hepatitis viruses B and C].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Guanine; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Interferons; Lamivudine; Mutation; Organophosphonates; Ribavirin; Viral Nonstructural Proteins | 2007 |
Drug resistance in antiviral treatment for infections with hepatitis B and C viruses.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Organophosphonates | 2007 |
Review article: current antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2008 |
[The ABC of viral hepatitis].
Topics: Adenine; Antiviral Agents; Hepatitis A; Hepatitis B; Hepatitis C; Hepatitis, Viral, Human; Humans; Interferon-alpha; Organophosphonates; Vaccination | 2008 |
[Management of chronic hepatitis B in treatment-naive patients].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Korea; Lamivudine; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Recombinant Proteins | 2008 |
[Management of antiviral-resistant chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Telbivudine; Thymidine; Treatment Outcome | 2008 |
[Combination therapy in chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2008 |
[Is it possible to stop nucleos(t)ide analogue based therapy in chronic hepatitis B?].
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Recurrence | 2008 |
Hepatitis B and liver transplantation: 2008 update.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B Vaccines; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2009 |
[Nucleoside and nucleotide analogs in the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Multicenter Studies as Topic; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2008 |
[Entecavir].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load; Virus Replication | 2008 |
[Clinical management of patients with chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Biopsy; Combined Modality Therapy; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Genotype; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver; Liver Transplantation; Male; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2008 |
[Hepatitis B in patients with HIV infection].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Comorbidity; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B; Hepatitis B Vaccines; Hepatitis B virus; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2008 |
Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues.
Topics: Adenine; Administration, Oral; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Graft Survival; Guanine; Hepatitis B; Humans; Immunoglobulins; Injections, Intramuscular; Lamivudine; Liver Transplantation; Nucleosides; Nucleotides; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome | 2009 |
Adefovir dipivoxil and pegylated interferon alpha for the treatment of chronic hepatitis B: an updated systematic review and economic evaluation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates | 2009 |
Meta-analysis: adefovir dipivoxil in combination with lamivudine in patients with lamivudine-resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2009 |
Current therapeutic strategies for recurrent hepatitis B virus infection after liver transplantation.
Topics: Adenine; Antiviral Agents; Asia; Guanine; Hepatitis B; Hepatitis B virus; Humans; Interferons; Lamivudine; Liver Transplantation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
On-treatment monitoring of chronic hepatitis B virus infection: an Asian-Pacific perspective.
Topics: Adenine; Antiviral Agents; Asia; Biomarkers; DNA, Viral; Drug Monitoring; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2010 |
Lamivudine or adefovir dipivoxil alone or combined with immunoglobulin for preventing hepatitis B recurrence after liver transplantation.
Topics: Adenine; Antiviral Agents; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Randomized Controlled Trials as Topic; Secondary Prevention | 2010 |
Inflammatory bowel disease and hepatitis B and C in Western Balkans: a referral centre study and review of the literature.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Female; Greece; Hepatitis B; Hepatitis C; Humans; Inflammatory Bowel Diseases; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Prevalence; Retrospective Studies; Ribavirin; Tenofovir; Treatment Outcome | 2010 |
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Guanosine; Hepatitis B; HIV Infections; Humans; Organophosphonates; Prodrugs; Structure-Activity Relationship; Tenofovir | 2011 |
[Interferon-based versus direct antiviral therapy in patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2011 |
Hepatitis B immunoglobulin and/or nucleos(t)ide analogues for prophylaxis against hepatitis b virus recurrence after liver transplantation: a systematic review.
Topics: Adenine; Antiviral Agents; Chi-Square Distribution; Drug Therapy, Combination; Evidence-Based Medicine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Risk Assessment; Risk Factors; Secondary Prevention; Time Factors; Treatment Outcome | 2011 |
Drug safety evaluation of adefovir in HBV infection.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic | 2011 |
Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding.
Topics: Adenine; Antiviral Agents; Breast Feeding; Female; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
[Lamivudine, adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2011 |
Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Postoperative Care | 2011 |
[A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review].
Topics: Adenine; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia | 2011 |
Comparative meta-analysis of adefovir dipivoxil monotherapy and combination therapy of adefovir dipivoxil and lamivudine for lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic | 2012 |
Adefovir dipivoxil in chronic hepatitis B: history and current uses.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates | 2012 |
[Research on molecular mechanism of drug resistance of adefovir dipivoxil].
Topics: Adenine; Animals; Antiviral Agents; Drug Resistance; Hepatitis B virus; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2012 |
Efficacy of lamivudine combined with adefovir dipivoxil versus entecavir monotherapy in patients with hepatitis B-associated decompensated cirrhosis: A meta-analysis.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Creatinine; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Regression of fibrosis after HBV antiviral therapy. Is cirrhosis reversible?
Topics: Adenine; Administration, Oral; Antiviral Agents; Carcinoma, Hepatocellular; Fibrosis; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Telbivudine; Tenofovir; Thymidine | 2014 |
Peginterferon alpha versus other antiviral regimes for Chinese HBeAg-positive chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; China; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols | 2013 |
Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B.
Topics: Adenine; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia | 2014 |
Efficacy and resistance in de novo combination lamivudine and adefovir dipivoxil therapy versus entecavir monotherapy for the treatment-naive patients with chronic hepatitis B: a meta-analysis.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Organophosphonates; Treatment Outcome | 2014 |
Liquid oral suspension adefovir dipivoxil (GS-02-526): an update on treatments for hepatitis B infection.
Topics: Adenine; Administration, Oral; Antiviral Agents; Clinical Trials as Topic; DNA, Viral; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Hepatitis B; Humans; Organophosphonates; Suspensions; Treatment Outcome | 2014 |
Pegylated interferon alfa for chronic hepatitis B: systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome; Viral Load | 2016 |
[Hepatitis B Virus Infection: Current Trends and Issues].
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Organophosphonates | 2015 |
Chronic hepatitis B in children: Therapeutic challenges and perspectives.
Topics: Adenine; Alanine Transaminase; Antigens, Viral; Antiviral Agents; Child; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Tolerance; Interferon-alpha; Lamivudine; Molecular Targeted Therapy; Organophosphonates; Practice Guidelines as Topic; Seroconversion; Telbivudine; Tenofovir; Thymidine; Viral Envelope Proteins | 2017 |
Relationship between nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B: A meta-analysis.
Topics: Adenine; Creatinine; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Kidney Diseases; Organophosphonates; Risk Factors | 2016 |
Bayesian Network Meta-Analysis for Assessing Adverse Effects of Anti-hepatitis B Drugs.
Topics: Adenine; Antiviral Agents; Bayes Theorem; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Network Meta-Analysis; Organophosphonates; Prospective Studies; Telbivudine; Tenofovir | 2019 |
Fanconi syndrome induced by adefovir dipivoxil: a case report and clinical review.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Quality of Life | 2020 |
139 trial(s) available for adenine and adefovir dipivoxil
| Article | Year |
|---|---|
Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Carnitine; Digestive System; Double-Blind Method; Female; HIV Core Protein p24; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; RNA, Viral | 1997 |
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carnitine; CD4 Lymphocyte Count; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Lymphocyte Count; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Semen; Sequence Analysis, RNA; T-Lymphocyte Subsets | 1997 |
Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from AIDS patients after prolonged adefovir dipivoxil therapy.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Drug Resistance, Microbial; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Phenotype; Recombination, Genetic; Viral Load; Zidovudine | 1998 |
Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro.
Topics: Adenine; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; In Vitro Techniques; Lamivudine; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine | 1999 |
Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Half-Life; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Models, Biological; Organophosphonates; Time Factors; Viral Load | 1999 |
A placebo-controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Organophosphonates; Treatment Outcome; Viral Load; Viremia | 1999 |
Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group.
Topics: Adenine; Adolescent; Antiviral Agents; Area Under Curve; Child; Child, Preschool; Female; Half-Life; HIV Infections; HIV-1; Humans; Infant; Male; Organophosphonates | 2000 |
Hepatitis B and adefovir depivoxil.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Controlled Clinical Trials as Topic; Hepatitis B; Hepatitis B virus; Humans; Organophosphonates; Treatment Outcome | 1997 |
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Cyclopropanes; Dideoxynucleosides; Disease Progression; Double-Blind Method; Drug Resistance, Viral; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Nelfinavir; Organophosphonates; Oxazines; Proportional Hazards Models; Reverse Transcriptase Inhibitors; Saquinavir; Sulfonamides; Treatment Failure; Viral Load | 2002 |
Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks.
Topics: Adenine; Adult; Antiviral Agents; Base Sequence; Carcinoma, Hepatocellular; Conserved Sequence; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Mutagenesis; Organophosphonates; Phenotype; Sequence Analysis, DNA; Tumor Cells, Cultured; Viral Load; Virus Replication | 2002 |
Once-daily quadruple-drug therapy with adefovir dipivoxil, Lamivudine, Didanosine, and efavirenz in treatment-naive human immunodeficiency virus type 1-infected patients.
Topics: Adenine; Adult; Alkynes; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kidney Diseases; Lamivudine; Male; Organophosphonates; Oxazines; Pulse Therapy, Drug; Reverse Transcriptase Inhibitors; RNA, Viral; Time Factors; Treatment Outcome | 2002 |
A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiviral Agents; Body Weight; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Fanconi Syndrome; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Male; Organophosphonates; RNA, Viral; Treatment Outcome | 2002 |
Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biopsy; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates | 2003 |
Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates | 2003 |
Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Base Sequence; Conserved Sequence; DNA, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phenotype; Prospective Studies | 2003 |
Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil1.
Topics: Adenine; Adult; Antiviral Agents; Asia; DNA, Viral; Europe; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; North America; Organophosphonates; Pacific Islands; Phylogeny; Prevalence; Racial Groups; Retrospective Studies | 2003 |
Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Amino Acid Motifs; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Proteins | 2004 |
Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy.
Topics: Adenine; Alanine Transaminase; Amino Acid Sequence; Antigens, Viral; Antiviral Agents; Biopsy; DNA-Directed DNA Polymerase; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Evolution, Molecular; Genes, Viral; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Liver; Molecular Sequence Data; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Viral Load | 2004 |
A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Alkynes; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; HIV-1; Humans; Indinavir; Male; Nelfinavir; Organophosphonates; Oxazines; Phenotype; Reverse Transcriptase Inhibitors; Treatment Failure | 2003 |
Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Double-Blind Method; Female; Glycosuria; Hematuria; Hepatitis B, Chronic; Humans; Kidney; Male; Middle Aged; Organophosphonates; Phosphorus; Proteinuria | 2004 |
Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil plus lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Failure; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Treatment Outcome | 2005 |
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Animals; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Time Factors | 2005 |
Systemic and renal pharmacokinetics of adefovir and tenofovir upon coadministration.
Topics: Adenine; Adolescent; Adult; Area Under Curve; Drug Interactions; Female; Half-Life; Humans; Kidney; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Adefovir dipivoxil alone or in combination with ongoing lamivudine in patients with decompensated liver disease and lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiviral Agents; Drug Combinations; Drug Resistance, Viral; Female; Hepatitis B; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2005 |
Clinical and virological response to adefovir dipovixil for lamivudine-resistant HBeAg-negative hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viremia | 2005 |
Efficacy and safety of adefovir dipivoxil in kidney recipients, hemodialysis patients, and patients with renal insufficiency.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Male; Middle Aged; Organophosphonates; Renal Dialysis; Renal Insufficiency; Viremia | 2005 |
[Safety and tolerance study of single oral dose of adefovir dipivoxil tablets in healthy volunteers].
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Diarrhea; Dose-Response Relationship, Drug; Female; Humans; Male; Nausea; Organophosphonates; Tablets; Young Adult | 2005 |
Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Evolution, Molecular; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Hepatitis B; Hepatitis B virus; Humans; Interferons; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Viral Load | 2006 |
Pharmacokinetics of telbivudine in healthy subjects and absence of drug interaction with lamivudine or adefovir dipivoxil.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine | 2006 |
Pharmacokinetics, safety and tolerance of single- and multiple-dose adefovir dipivoxil in healthy Chinese subjects.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Dose-Response Relationship, Drug; Female; Humans; Male; Organophosphonates | 2007 |
Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2006 |
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates | 2006 |
[A double-blind, randomized, lamivudine-controlled clinical trial of DAIDING (adefovir dipivoxil) for lamivudine-resistant patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2006 |
[A clinical study of adefovir dipivoxil, made in China, for treatment of hepatitis B e antigen-positive patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Middle Aged; Mutation; Organophosphonates; Young Adult | 2006 |
Efficacy of adefovir dipivoxil in the treatment of lamivudine-resistant hepatitis B virus genotype C infection.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2007 |
Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Salvage Therapy; Treatment Outcome; Virus Replication | 2007 |
Virological response and incidence of adefovir resistance in lamivudine-resistant patients treated with adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2006 |
Efficacy and safety of adefovir dipivoxil 20 mg daily in HBeAg-positive patients with lamivudine-resistant hepatitis B virus and a suboptimal virological response to adefovir dipivoxil 10 mg daily.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2007 |
Adefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: final long-term results.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney Diseases; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Secondary Prevention; Waiting Lists | 2007 |
Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Bilirubin; Creatinine; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2007 |
Adefovir dipivoxil alone or in combination with lamivudine for three months in patients with lamivudine resistant compensated chronic hepatitis B.
Topics: Adenine; Adult; Aged; Alanine Transaminase; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome | 2007 |
[Three year adefovir dipivoxil treatment for hepatitis B e antigen-positive chronic hepatitis B patients].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Young Adult | 2007 |
[A clinical study of adefovir dipivoxil in treating lamivudine refractory HBeAg-positive chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2007 |
Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Immunity, Cellular; Kinetics; Male; Middle Aged; Models, Immunological; Organophosphonates; T-Lymphocytes; Treatment Outcome; Viral Load; Viremia; Virus Replication | 2007 |
Second tenofovir phase III study for the chronic HBV reaches primary endpoint.
Topics: Adenine; Anti-HIV Agents; Double-Blind Method; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2007 |
Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine; Viral Load | 2007 |
[Diammonium glycyrrhizinate does not affect efficacy of adefovir dipivoxil therapy in patients with HBeAg-positive chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Double-Blind Method; Glycyrrhizic Acid; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Treatment Outcome | 2007 |
[Efficacy of adefovir dipivoxil was not related to genotypes B and C of hepatitis B virus: a randomized, double-blind, multicenter clinical study].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2007 |
Clinical trial: effects of adefovir dipivoxil therapy in Asian and Caucasian patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Double-Blind Method; Drug Administration Schedule; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Placebos; Regression Analysis; Treatment Outcome; White People | 2007 |
Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4+ T-cell reactivity.
Topics: Adenine; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphocyte Activation; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Virus Replication | 2008 |
[Adefovir dipivoxil compassionate use program in Spain: efficacy and resistance analysis].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Spain | 2007 |
[A clinical study of adefovir dipivoxil treatment for chronic hepatitis patients with cirrhosis in their decompensation period].
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2007 |
96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates | 2008 |
The pharmacokinetics and safety of adefovir dipivoxil in children and adolescents with chronic hepatitis B virus infection.
Topics: Adenine; Adolescent; Antiviral Agents; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2008 |
Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2008 |
Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2008 |
Sequential combination therapy leads to biochemical and histological improvement despite low ongoing intrahepatic hepatitis B virus replication.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon alpha-2; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Virus Replication | 2008 |
Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B.
Topics: Adenine; Adolescent; Age Factors; Alanine Transaminase; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Male; Organophosphonates; Treatment Outcome | 2008 |
[Adefovir dipivoxil treatment of hepatic cirrhosis complicated with hepatitis B virus associated glomerulonephritis].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Female; Glomerulonephritis; Hepatitis B; Hepatitis B virus; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Young Adult | 2008 |
Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants.
Topics: Adenine; Adolescent; Adult; Cell Line, Tumor; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Europe; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Patient Compliance; Phenotype; Reverse Transcriptase Inhibitors; Time Factors; Treatment Failure; United States; Viral Load; Virus Replication | 2008 |
[Lamivudine and adefovir dipivoxil combination treatment for liver cirrhosis patients with CHB].
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2008 |
Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2008 |
Efficacy and safety of adefovir dipivoxil plus pegylated interferon-alpha2a for the treatment of lamivudine-resistant hepatitis B virus infection in HIV-infected patients.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors; Treatment Outcome | 2008 |
Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load | 2008 |
Complex dynamics of hepatitis B virus resistance to adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; Virus Replication | 2009 |
Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Biopsy; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reagent Kits, Diagnostic; Treatment Outcome | 2009 |
Mutations associated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Treatment Outcome | 2009 |
[A study on the treatment of chronic hepatitis B with YMDD mutation].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Young Adult | 2009 |
Pharmacokinetics of tacrolimus co-administered with adefovir dipivoxil to liver transplant recipients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Hepatitis B; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Organophosphonates; Tacrolimus; Young Adult | 2009 |
Adefovir dipivoxil resistance patterns in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Cell Line; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; RNA-Directed DNA Polymerase | 2009 |
Adefovir plus lamivudine are more effective than adefovir alone in lamivudine-resistant HBeAg- chronic hepatitis B patients: a 4-year study.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2010 |
[A clinical study of adefovir dipivoxil treatment for chronic hepatitis patients with cirrhosis in their decompensation period].
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Collagen; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome | 2009 |
Full-length hepatitis B virus sequences from naïve patients with fluctuation of viral load during ADV monotherapy.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; China; DNA, Viral; Female; Genome, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Sequence Deletion; Treatment Failure; Viral Load; Viral Proteins; Young Adult | 2010 |
A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2009 |
[The analyse of effectiveness in HBeAg-positive chronic viral hepatitis B treated by adefovir dipivoxil combined with bicyclol].
Topics: Adenine; Adolescent; Adult; Aged; Biphenyl Compounds; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2009 |
[Comparison of efficacy between adefovir dipivoxil and entecavir in patients with chronic hepatitis B].
Topics: Adenine; Administration, Oral; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Polymerase Chain Reaction; Prospective Studies; Treatment Outcome; Virus Replication | 2010 |
Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Korea; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Young Adult | 2010 |
Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2011 |
Tenofovir is effective alone or with emtricitabine in adefovir-treated patients with chronic-hepatitis B virus infection.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Medication Adherence; Middle Aged; Mutation; Organophosphonates; Tenofovir | 2010 |
[Efficacy and durability of generic adefovir dipivoxil in patients with HBeAg positive chronic hepatitis].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Treatment Outcome; Young Adult | 2009 |
[Short-term efficacy of adefovir dipivoxil as an add-on therapy in the pegylated IFNalpha-2a treatment for HBeAg positive chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2010 |
[Efficacy of the 96-week adefovir dipivoxil therapy in patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Young Adult | 2010 |
[Observation on effect of peg interferon lphaa-2a treating lamivudine resistant chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Watchful Waiting | 2010 |
Peginterferon plus adefovir versus either drug alone for hepatitis delta.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Analysis of Variance; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B Surface Antigens; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Viral Load; Young Adult | 2011 |
[Influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; T-Lymphocytes, Cytotoxic; Young Adult | 2010 |
Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents.
Topics: Adenine; Adult; Antiviral Agents; Blood; DNA, Circular; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Histocytochemistry; Humans; Liver; Male; Middle Aged; Organophosphonates; Placebos; Treatment Outcome; Viral Load | 2011 |
No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus.
Topics: Adenine; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Gene Products, pol; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir | 2011 |
[One-year combination therapy de novo of adefovir dipivoxil and lamivudine for decompensated cirrhosis related to HBV].
Topics: Adenine; Adult; Antiviral Agents; China; Drug Therapy, Combination; Female; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2011 |
[The levels of HBsAg can predict the efficacy of peglated interferon-alpha 2a combined with adefovir dipivoxil, in HBeAg-positive chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Recombinant Proteins; Treatment Outcome | 2011 |
[Relationship between HBeAg seroconversion with genotypes and HBV specific CTL in patients with chronic hepatitis B treated with Adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunity, Cellular; Male; Organophosphonates; T-Lymphocytes, Cytotoxic | 2011 |
Five years of treatment with adefovir dipivoxil in Chinese patients with HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Asian People; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Function Tests; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load; Viremia; Young Adult | 2012 |
[A clinical study on the efficacy of HBeAg-positive chronic hepatitis B patients treated with adefovir dipivoxil for 4 years].
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Virus Replication | 2011 |
[Polish multicenter study on safety and efficacy of adefovir dipivoxil in the treatment of lamivudine resistant chronic hepatitis B in adults (HEP 2008)].
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Poland; Treatment Outcome; Viral Load | 2011 |
Prevention of de novo hepatitis B with adefovir dipivoxil in recipients of liver grafts from hepatitis B core antibody-positive donors.
Topics: Adenine; Adult; Aged; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Humans; Liver; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Tissue Donors | 2012 |
Improved efficacy by individualized combination therapy with Peg IFN-a 2a and ADV in HBeAg positive chronic hepatitis B patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Chi-Square Distribution; China; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Precision Medicine; Prospective Studies; Recombinant Proteins; Time Factors; Treatment Outcome | 2012 |
Efficacy and safety of long-term adefovir dipivoxil therapy in children with chronic hepatitis B infection.
Topics: Adenine; Adolescent; Child; Child, Preschool; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Placebos; Treatment Outcome | 2012 |
[Clinical study on Baihua Xianglian detoxification recipe combined with adefovir dipivoxil in treating HBeAg positive chronic hepatitis].
Topics: Adenine; Adult; Antiviral Agents; Drugs, Chinese Herbal; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phytotherapy; Treatment Outcome; Young Adult | 2012 |
Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Prospective Studies; Recurrence; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2012 |
Virologic responses to add-on adefovir dipivoxil treatment versus entecavir monotherapy in children with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adolescent; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
[Experimental study on effect of dahuang zhechong wan combined with adefovir dipivoxil in preventing hepatic fibrosis in patients with chronic hepatitis B].
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
[The clinical efficacy and safety of adefovir dipivoxil in combination with bicyclol for the treatment of senior patients with chronic hepatitis B].
Topics: Adenine; Aged; Aged, 80 and over; Antiviral Agents; Biphenyl Compounds; DNA, Viral; Female; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates | 2011 |
[The therapeutic effect of Anluohuaxian capsule combined with adefovir dipivoxil on patients with chronic hepatitis B and influence on hepatic histology].
Topics: Adenine; Adult; Antiviral Agents; Drugs, Chinese Herbal; Female; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates; Phytotherapy; Treatment Outcome | 2012 |
Comparison of the antiviral effects of entecavir and adefovir dipivoxil in chronic HBV infection: a randomized control trial.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Bilirubin; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Virus Replication; Young Adult | 2012 |
Pharmacokinetic properties of single-dose lamivudine/adefovir dipivoxil fixed-dose combination in healthy Chinese male volunteers.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Area Under Curve; Asian People; Biological Availability; Capsules; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Half-Life; Hong Kong; Humans; Lamivudine; Male; Metabolic Clearance Rate; Organophosphonates; Tablets; Therapeutic Equivalency; Young Adult | 2013 |
[Efficacy of combination therapy of lamivudine and adefovir dipivoxyl for patients with hepatitis B-induced decompensated liver cirrhosis].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; End Stage Liver Disease; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2012 |
Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Phosphorous Acids; Treatment Outcome; Viral Load | 2013 |
[Efficacy and safety of telbivudine and adefovir dipivoxil for the treatment of chronic hepatitis B patients with high level hepatitis B virus load and hepatitis B e antigen-positivity].
Topics: Adenine; Adult; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2012 |
Efficacy and safety of telbivudine plus adefovir dipivoxil combination therapy and entecavir monotherapy for HBeAg-positive chronic hepatitis B patients with resistance to adefovir dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2013 |
Efficacy of telbivudine treatment for hepatitis B e antigen-positive chronic hepatitis B patients with poor response to adefovir dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome; Viral Load; Virus Replication | 2013 |
Two years efficiency of lamivudine and adefovir dipivoxil combined therapy in chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies | 2013 |
Antiviral efficacies of currently available rescue therapies for multidrug-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2013 |
Efficacy of combined therapy in patients with hepatitis B virus-related decompensated cirrhosis.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Chi-Square Distribution; China; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2013 |
[Clinical efficacy of various antiviral-based strategies to treat chronic hepatitis patients with positivity for hepatitis B e antigen and rtN236T mutation].
Topics: Adenine; Adult; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Young Adult | 2013 |
De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.
Topics: Adenine; Adult; Alanine Transaminase; Analysis of Variance; Antiviral Agents; Biomarkers; Chi-Square Distribution; China; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Time Factors; Treatment Outcome | 2013 |
Population pharmacokinetics of adefovir dipivoxil tablets in healthy Chinese volunteers.
Topics: Adenine; Adult; Antiviral Agents; Female; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Models, Biological; Organophosphonates; Tablets | 2014 |
[Therapeutic effect of antiviral regimens for chronic hepatitis B refractory to lamivudine plus adefovir].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Mutation; Organophosphonates; Real-Time Polymerase Chain Reaction; Recombinant Proteins | 2013 |
Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice.
Topics: Adenine; Adult; Animals; Antibody Formation; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Middle Aged; Organophosphonates; T-Lymphocytes; Vaccines, DNA; Young Adult | 2015 |
Entecavir 1mg versus combined lamivudine/adefovir dipivoxil in chronic HBV Egyptian patients resistant to LAM monotherapy, non-randomised controlled study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Egypt; Female; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2014 |
Curative effect of combined lamivudine, adefovir dipivoxil, and stem cell transplantation on decompensated hepatitis B cirrhosis.
Topics: Adenine; alpha-Fetoproteins; Cholinesterases; Combined Modality Therapy; Female; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Organophosphonates; Prothrombin Time; Stem Cell Transplantation | 2014 |
Identification of serum cytokine profiles associated with HBeAg seroconversion following antiviral treatment interruption.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Cytokines; Female; Hepatitis B e Antigens; Hepatitis C, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Placebos; Serum; T-Lymphocytes; Withholding Treatment; Young Adult | 2014 |
[Long-term efficacy and safety of telbivudine as monotherapy and as combination therapy with adefovir dipivoxil in HBeAg-positive chronic hepatitis B patients].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Young Adult | 2014 |
Kinetics and prediction of HBsAg loss during long-term therapy with nucleos(t)ide analogues of different potency in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates | 2014 |
Tenofovir disoproxil fumarate vs adefovir dipivoxil in Chinese patients with chronic hepatitis B after 48 weeks: a randomized controlled trial.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Asian People; China; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2015 |
Randomized, three-arm study to optimize lamivudine efficacy in hepatitis B e antigen-positive chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Young Adult | 2015 |
An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; Chi-Square Distribution; Drug Therapy, Combination; Female; Gene Expression Profiling; Genetic Markers; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver; Logistic Models; Male; Middle Aged; Multivariate Analysis; Oligonucleotide Array Sequence Analysis; Organophosphonates; Patient Selection; Polyethylene Glycols; Precision Medicine; Predictive Value of Tests; Recombinant Proteins; Reproducibility of Results; Time Factors; Treatment Outcome | 2015 |
Preemptive adefovir versus lamivudine for prevention of hepatitis B reactivation in chronic hepatitis B patients undergoing chemotherapy.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Neoplasms; Organophosphonates; Virus Activation; Young Adult | 2015 |
Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Telbivudine; Thymidine | 2015 |
The curative effect of adefovir dipivoxil treating HBeAg negative chronic hepatitis B and treating HBeAg positive chronic hepatitis B combining interferon α-2b.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Combinations; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Recombinant Proteins | 2015 |
Cost-effectiveness of Lamivudine, Telbivudine, Adefovir Dipivoxil and Entecavir on decompensated hepatitis B virus-related cirrhosis.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2016 |
[Efficacy Observation of Yiguanjian Decoction Combined Adefovir Dipivoxil Tablet in Treating HBeAg Negative Chronic Viral Hepatitis B Active Compensated Liver Cirrhosis Patients].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Bilirubin; DNA, Viral; Drugs, Chinese Herbal; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Organophosphonates; Tablets | 2016 |
CONSORT: Effects of adding adefovirdipivoxil to peginterferon alfa-2a at different time points on HBeAg-positivepatients: A prospective, randomized study.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Seroconversion | 2016 |
Effect of nucleoside analogues in the treatment of hepatitis B cirrhosis and its effect on Th17 cell.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Th17 Cells; Treatment Outcome | 2017 |
Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins | 2018 |
Addition of nucleoside analogues to peg-IFNα-2a enhances virological response in chronic hepatitis B patients without early response to peg-IFNα-2a: a randomized controlled trial.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Sustained Virologic Response | 2017 |
Effects of the combined administration of entecavir and adefovir dipivoxil to improve hepatic fibrosis in hepatitis B patients with interferon resistance.
Topics: Adenine; Aged; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Bilirubin; Creatinine; Drug Resistance, Viral; Drug Therapy, Combination; End Stage Liver Disease; Female; Gene Products, pol; Guanine; Hepatitis B, Chronic; Humans; Interferons; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Severity of Illness Index | 2017 |
Tenofovir
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hospital Costs; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Failure; Viral Load | 2017 |
Ten-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B virus infection.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Internationality; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2019 |
Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients: A Randomized Controlled 48-Week Trial.
Topics: Adenine; Adult; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Medicine, Chinese Traditional; Organophosphonates; Young Adult | 2020 |
357 other study(ies) available for adenine and adefovir dipivoxil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adenine; Animals; Antiviral Agents; beta-Cyclodextrins; Biological Availability; Cyclodextrins; Macaca fascicularis; Male; Organophosphonates; Prodrugs; Propylene Glycols; Retroviridae; Suspensions | 1994 |
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1995 |
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; In Vitro Techniques; Leukemia, Experimental; Mice; Mice, Inbred Strains; Mice, SCID; Moloney murine sarcoma virus; Organophosphonates; Prodrugs; Rats; Retroviridae; Retroviridae Infections; Sarcoma, Experimental; Tumor Virus Infections | 1996 |
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Drug Resistance, Microbial; Fibroblasts; Foscarnet; Humans; Lung; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid | 1996 |
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Topics: Adenine; Animals; Antiviral Agents; Caco-2 Cells; Chromatography, High Pressure Liquid; Humans; Intestinal Absorption; Organophosphonates; Prodrugs; Swine | 1997 |
Inhibition of murine macrophage nitric oxide synthase expression by a pivoxil prodrug of antiviral acyclic nucleotide analogue 9-(2-phosphonomethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Prodrugs; RNA, Messenger | 1997 |
Evaluation of anti-hepatitis B virus (HBV) drugs using the HBV transgenic mouse: application of the semiquantitative polymerase chain reaction (PCR) for serum HBV DNA to monitor the drug efficacy.
Topics: Adenine; Animals; Antiviral Agents; DNA Replication; DNA, Viral; Drug Monitoring; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Lamivudine; Liver; Mice; Mice, Transgenic; Polymerase Chain Reaction; Virion; Virus Replication | 1997 |
Antiviral drug susceptibility of human herpesvirus 8.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA Replication; DNA, Viral; Herpesvirus 8, Human; Humans; Organophosphonates; Organophosphorus Compounds | 1997 |
Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Dogs; Fasting; Food-Drug Interactions; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Organophosphonates; Pentagastrin; Solubility; Tablets | 1997 |
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Topics: Adenine; Antiviral Agents; Caco-2 Cells; Chromatography, Ion Exchange; Esters; Humans; Organophosphonates; Prodrugs | 1998 |
Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity.
Topics: Adenine; Anti-HIV Agents; Cloning, Molecular; Escherichia coli; HIV Reverse Transcriptase; Mutation; Organophosphonates; Poly A; Recombinant Proteins; RNA; Substrate Specificity; Templates, Genetic | 1998 |
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.
Topics: Adenine; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Epithelium; Humans; Indomethacin; Verapamil | 1998 |
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine | 1998 |
Three new drugs for HIV infection.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Central Nervous System Diseases; Cyclopropanes; Dideoxynucleosides; Dizziness; Drug Therapy, Combination; Headache; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors | 1998 |
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL5; Female; Fibrosis; Macrophages, Peritoneal; Nitric Oxide; Organ Size; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Inbred Lew; Spleen; Tenofovir | 1999 |
Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.
Topics: Adenine; Adult; Antiviral Agents; Carrier State; DNA-Directed DNA Polymerase; Drug Resistance; Female; Hepatitis B; Hepatitis B virus; Humans; Immunization, Passive; Kidney Transplantation; Lamivudine; Liver Failure; Liver Transplantation; Mutation; Organophosphonates | 1999 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Cytomegalovirus; Cytomegalovirus Infections; Double-Blind Method; Drugs, Investigational; HIV Infections; Humans; Macaca fascicularis; Male; Organophosphonates; Protein Binding; Randomized Controlled Trials as Topic; Semen | 1999 |
NDA submitted for adefovir.
Topics: Adenine; Carnitine; Drug Approval; Drug Packaging; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; United States; United States Food and Drug Administration | 1999 |
Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Codon; Cohort Studies; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; HIV Infections; Humans; Logistic Models; Male; Middle Aged; Mutation; Organophosphonates; Oxazines; Protease Inhibitors; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Treatment Outcome; Viral Load | 2000 |
Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2000 |
In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.
Topics: Adenine; Animals; Antiviral Agents; Intestinal Absorption; Male; Organophosphonates; Prodrugs; Rats; Rats, Wistar; Verapamil | 2000 |
The treatment pipeline: new therapies are on the way.
Topics: Adenine; AIDS Vaccines; Anti-HIV Agents; Enfuvirtide; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; Humans; Interleukin-2; Organophosphonates; Peptide Fragments; Ritonavir | 1999 |
Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil.
Topics: Acids; Adenine; Antiviral Agents; Carbonates; Chemistry, Pharmaceutical; Dimerization; Organophosphonates | 2000 |
Efficiency comparisons of rank and permutation tests based on summary statistics computed from repeated measures data.
Topics: Acquired Immunodeficiency Syndrome; Adenine; HIV-1; Humans; Nevirapine; Organophosphonates; Protease Inhibitors; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Statistics as Topic; Viral Load | 2001 |
[Current treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Anti-Inflammatory Agents; Antiviral Agents; DNA Replication; Famciclovir; Forecasting; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Prednisone; Prognosis; Reverse Transcriptase Inhibitors; Time Factors; Virus Replication | 2001 |
A rocky road for nucleotide analogs.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytomegalovirus Retinitis; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds | 1998 |
Expanded access.
Topics: Adenine; Anti-HIV Agents; Carbamates; Drug Approval; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Sulfonamides; Treatment Failure; United States; United States Food and Drug Administration | 1999 |
CRIA clinical trials.
Topics: Adenine; Alkynes; Anabolic Agents; Anti-HIV Agents; Benzoxazines; Blood Glucose; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Organophosphonates; Oxandrolone; Oxazines; Patient Selection; Reverse Transcriptase Inhibitors; Weight Loss | 1998 |
Successful treatment with adefovir dipivoxil in a patient with fibrosing cholestatic hepatitis and lamivudine resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis, Biliary; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Occupational Diseases; Organophosphonates; Treatment Outcome | 2001 |
Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Microbial; Female; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects; Viral Load | 2001 |
Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.
Topics: Adenine; Administration, Oral; Animals; Chemistry, Clinical; Chronic Disease; Disease Models, Animal; DNA, Viral; Hepatitis B; Hepatitis B Virus, Woodchuck; Liver; Marmota; Organophosphonates; Treatment Outcome | 2001 |
Human immunodeficiency virus (HIV) Type 1 reverse transcriptase resistance mutations in hepatitis B virus (HBV)-HIV-coinfected patients treated for HBV chronic infection once daily with 10 milligrams of adefovir dipivoxil combined with lamivudine.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; DNA, Viral; Dose-Response Relationship, Drug; Hepatitis B; Hepatitis B virus; Lamivudine; Liver; Mice; Mice, Transgenic; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA, Viral; Time Factors; Viral Load | 2002 |
Adefovir nephrotoxicity and mitochondrial DNA depletion.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; DNA, Mitochondrial; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Kidney Tubules; Mitochondria; Organophosphonates; Renal Insufficiency; Stavudine | 2002 |
Treatment of recurrent hepatitis B infection in liver transplant recipients.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Famciclovir; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Liver Transplantation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2002 |
FDA notifications. New treatment approved for chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Approval; Hepatitis B, Chronic; Humans; Kidney; Organophosphonates; United States; United States Food and Drug Administration | 2002 |
From the Food and Drug Administration.
Topics: Adenine; Anastrozole; Antineoplastic Agents, Hormonal; Antiviral Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Hepatitis B, Chronic; Humans; Nitriles; Organophosphonates; Triazoles; United States; United States Food and Drug Administration | 2002 |
FDA recommends hepatitis B drug.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Approval; Hepatitis B; Humans; Kidney Diseases; Organophosphonates; United States; United States Food and Drug Administration | 2002 |
Predominance of pre-S1 mutated hepatitis B virus in a patient following treatment with adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Gene Deletion; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Mutation; Organophosphonates; Protein Precursors; Reverse Transcriptase Inhibitors; Salvage Therapy | 2003 |
Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency.
Topics: Adenine; Adult; Antiviral Agents; Bacterial Infections; Cholestasis; Drug Resistance, Microbial; Fibrosis; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver; Liver Cirrhosis; Male; Organophosphonates; Peritonitis; Recurrence; Renal Insufficiency; Reverse Transcriptase Inhibitors | 2003 |
Suppressing hepatitis B without resistance--so far, so good.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Organophosphonates | 2003 |
Unsuccessful rescue therapy with adefovir dipivoxil for lamivudine resistant HBV in a patient with liver failure.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Fatal Outcome; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Failure, Acute; Middle Aged; Organophosphonates; Salvage Therapy | 2003 |
Evaluation of mitochondrial DNA content and enzyme levels in tenofovir DF-treated rats, rhesus monkeys and woodchucks.
Topics: Adenine; Animals; Citrate (si)-Synthase; DNA, Mitochondrial; Electron Transport Complex IV; Macaca mulatta; Marmota; Mitochondria; Organ Specificity; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Species Specificity; Tenofovir | 2003 |
[Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry].
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, Liquid; Macaca mulatta; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2003 |
Adefovir dipivoxil for hepatitis B e antigen-positive chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Placebos; Research Design | 2003 |
Antiviral Research--16th Annual International Conference. Satellite symposium: clinical update on antiviral drugs. 27 April-1 May 2003, Savannah, GA, USA.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Enfuvirtide; Ganciclovir; Hepatitis B; HIV Envelope Protein gp41; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Peptide Fragments; Tenofovir; Valganciclovir | 2003 |
[The first nucleotide analog permitted. New hepatitis B therapy helps the problem patients, too].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Drug Resistance; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Placebos; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors | 2003 |
Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Viral Proteins | 2003 |
[New option for successful therapy of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Germany; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2003 |
Use of adefovir in the treatment of the chronic hepatitis B virus infection with resistance to lamivudine.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Patient Selection; Recurrence; Treatment Failure; Viremia | 2003 |
Recent studies of adefovir dipivoxil for hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Child; Controlled Clinical Trials as Topic; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Organophosphonates; Treatment Outcome | 2003 |
Treatment of pre- and post-liver transplantation HBV infection: Should we aim at combination therapy?
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Organophosphonates | 2003 |
Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Child; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2003 |
Resistance of HBV to adefovir dipivoxil: a case for combination antiviral therapy?
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Lamivudine; Mutation; Organophosphonates | 2003 |
Antivirals for the treatment of chronic hepatitis B: current and future options.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Survival Analysis; Viral Load | 2003 |
[Update in the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Evaluation; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2004 |
The renal tolerance of low-dose adefovir dipivoxil by lamivudine-resistant individuals co-infected with hepatitis B and HIV.
Topics: Adenine; Administration, Oral; Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; HIV Infections; Humans; Kidney; Kidney Function Tests; Lamivudine; Male; Maximum Tolerated Dose; Middle Aged; Organophosphonates; Prospective Studies; Risk Assessment; Treatment Outcome | 2004 |
Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2003 |
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Humans; Microglia; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats; Rats, Wistar; RNA, Messenger; Tritium | 2004 |
Favourable outcome of adefovir-dipivoxil treatment in acute de novo hepatitis B after liver transplantation.
Topics: Acute Disease; Adenine; Antiviral Agents; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2004 |
[New antiviral agent. Hepatitis B therapy with slight resistance risk].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors | 2003 |
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antigens, Bacterial; Antiviral Agents; Bacterial Toxins; Binding Sites; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Exotoxins; Hepatitis B, Chronic; Kinetics; Models, Molecular; Organophosphonates; Protein Conformation; Recombinant Proteins; Spodoptera; Transfection | 2004 |
Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Failure; Liver Transplantation; Living Donors; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin.
Topics: Adenine; Adult; Antiviral Agents; Cholestasis, Intrahepatic; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Core Antigens; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Organophosphonates; Promoter Regions, Genetic; Reoperation; Treatment Outcome | 2004 |
Adefovir dipivoxil as a treatment for hepatic failure caused by lamivudine-resistant HBV strains.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Failure; Male; Middle Aged; Organophosphonates; Retreatment; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
[Adefovir dipivoxil--a further step in the control of chronic viral hepatitis B. There is still a long way to go].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B virus; Lamivudine; Mutation; Nucleic Acid Synthesis Inhibitors; Oligodeoxyribonucleotides; Organophosphonates; Organothiophosphorus Compounds; Reverse Transcriptase Inhibitors; Viral Proteins; Virus Replication | 2004 |
[A case of liver cirrhosis B resistant to lamivudine showing the clinical effect of adefovir dipivoxil].
Topics: Adenine; Amino Acid Motifs; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.
Topics: Adenine; Antiviral Agents; Biopsy; DNA, Circular; DNA, Viral; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Organophosphonates; Polymerase Chain Reaction | 2004 |
Practical management of chronic hepatitis B infection.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Patient Selection; Treatment Outcome | 2004 |
A novel pattern (sW195a) in surface gene of HBV DNA due to YSDD (L180M plus M204S) mutation selected during lamivudine therapy and successful treatment with adefovir dipivoxil.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation, Missense; Organophosphonates | 2004 |
Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model.
Topics: Adenine; Administration, Oral; Amino Acid Motifs; Amino Acid Substitution; Animals; Antiviral Agents; Disease Models, Animal; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Virus, Woodchuck; Lamivudine; Marmota; Mutation, Missense; Organophosphonates; Protein Structure, Tertiary; Viremia; Virus Replication | 2004 |
Adefovir dipivoxil to prevent exacerbation of lamivudine-resistant hepatitis B infection during chemotherapy for non-Hodgkin's lymphoma.
Topics: Adenine; Adult; Antiviral Agents; Carrier State; Drug Resistance; Female; Hepatitis B; Humans; Lamivudine; Lymphoma, Non-Hodgkin; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Outcomes in liver transplant recipients with hepatitis B virus: resistance and recurrence patterns from a large transplant center over the last decade.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Graft Survival; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Failure; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Survival Analysis; Treatment Outcome | 2004 |
Adefovir dipivoxil as the rescue therapy for lamivudine-resistant hepatitis B post liver transplant.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Child; Drug Resistance; Follow-Up Studies; Hepatitis B; Humans; Lamivudine; Liver Transplantation; Middle Aged; Organophosphonates; Postoperative Complications; Recurrence; Retrospective Studies | 2004 |
Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.
Topics: Adenine; Adult; Alanine Transaminase; Drug Resistance, Microbial; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Safety; Treatment Outcome | 2004 |
Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes.
Topics: Adenine; Animals; Antiviral Agents; Disease Models, Animal; DNA, Circular; DNA, Viral; Hepatitis B, Chronic; Hepatocytes; Mice; Organophosphonates; Transplantation, Heterologous; Tupaia; Urokinase-Type Plasminogen Activator | 2005 |
Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys.
Topics: Adenine; Animals; Antiviral Agents; Autoradiography; Carbon Radioisotopes; Dose-Response Relationship, Drug; Drug Delivery Systems; Haplorhini; Hepatitis B, Chronic; Kidney; Liver; Mesylates; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Species Specificity; Tissue Distribution | 2004 |
Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Drug Resistance, Viral; Female; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prothrombin Time; Serum Albumin; Viral Load | 2005 |
Adefovir dipivoxil for chemotherapy-induced activation of hepatitis B virus infection.
Topics: Acute Disease; Adenine; Aged; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Hepatitis B; Hepatitis B virus; Humans; Male; Organophosphonates; Prostatic Neoplasms; Virus Activation | 2005 |
Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure.
Topics: Adenine; Adult; DNA, Viral; Drug Therapy, Combination; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Polymerase Chain Reaction; Treatment Failure | 2005 |
[Determination of adefovir dipivoxil and its degradation products by reversed-phase high performance liquid chromatography].
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Indicators and Reagents; Organophosphonates | 2004 |
Adefovir dipivoxil added to ongoing lamivudine therapy in patients with lamivudine-resistant hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Combinations; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2005 |
[Therapeutic effect of adefovir dipivoxil on recurrent or de novo infection of hepatitis B virus after liver transplantation: a preliminary report].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2005 |
[Advances in treatment of chronic hepatitis B].
Topics: Adenine; Animals; Antiviral Agents; Drug Therapy, Combination; Genetic Therapy; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Phytotherapy | 2005 |
Prophylaxis of hepatitis B virus recurrence after liver transplantation in carriers of lamivudine-resistant mutants.
Topics: Adenine; Adult; Antibodies, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors; Secondary Prevention | 2005 |
Treatment with adefovir dipivoxil in a renal transplant patient with renal insufficiency and lamivudine-resistant hepatitis B infection.
Topics: Adenine; Antiviral Agents; Creatinine; Drug Resistance, Viral; Follow-Up Studies; Hepatitis B; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2005 |
Adefovir dipivoxil therapy in liver transplant recipients with lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Immunosuppression Therapy; Lamivudine; Liver Transplantation; Middle Aged; Organophosphonates; Retrospective Studies; Viral Load | 2005 |
[Efficacy and safety of adefovir dipivoxil in patients with decompensated liver cirrhosis with Lamivudine resistance compared to patients with compensated liver disease].
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2005 |
The maze of treatments for hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2005 |
[Influence of nucleoside analogues resistance on anti-HBV treatment].
Topics: Adenine; Antiviral Agents; Dideoxynucleosides; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2005 |
Human multidrug resistance associated protein 4 confers resistance to camptothecins.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Drug Resistance, Neoplasm; Glutathione; Humans; Irinotecan; Methotrexate; Multidrug Resistance-Associated Proteins; Organophosphonates; Paclitaxel | 2005 |
[Adefovir dipivoxil in treatment of decompensated liver cirrhosis patients with YMDD mutation].
Topics: Adenine; Adult; Aged; Amino Acid Motifs; Antiviral Agents; DNA-Directed DNA Polymerase; Female; Hepatic Encephalopathy; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Mutation; Organophosphonates; Protein Structure, Tertiary; Recurrence; Reverse Transcription | 2005 |
Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects; Polymerase Chain Reaction; Prospective Studies; RNA, Viral; Treatment Outcome | 2006 |
Treatment of lamivudine-resistant hepatitis B in HIV-infected persons: is adefovir dipivoxil the answer?
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Antibodies; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2006 |
Clinical and virological effects during two years of ongoing adefovir dipivoxil in the treatment of lamivudine-resistant chronic hepatitis B infection.
Topics: Adenine; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Renal Dialysis; Treatment Failure; Virus Replication | 2005 |
Study on the efficacy and safety of adefovir dipivoxil treatment in post-liver transplant patients with hepatitis B virus infection and lamivudine-resistant hepatitis B virus.
Topics: Adenine; Alanine Transaminase; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Liver Transplantation; Male; Organophosphonates; Recurrence; Retrospective Studies; Safety | 2005 |
Cost-effectiveness analysis of lamivudine and adefovir dipivoxil in the treatment of patients with HBeAg-negative chronic hepatitis B.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Spain | 2006 |
[Lamivudine and adefovir resistance in a patient with HBeAg negative chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2006 |
Resistance to adefovir dipivoxil in lamivudine resistant chronic hepatitis B patients treated with adefovir dipivoxil.
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Genotype; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors | 2006 |
Adefovir dipivoxil-associated thrombocytopenia in a patient with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Thrombocytopenia | 2006 |
Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis, Autoimmune; Humans; Lamivudine; Liver Transplantation; Male; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2006 |
[Chronic hepatitis B: from old braids and new brooms].
Topics: Adenine; Antiviral Agents; Germany; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Medicine in the Arts; Models, Anatomic; Mutation; Organophosphonates; Prognosis; Sculpture; Viral Load | 2005 |
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Female; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors | 2005 |
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors | 2006 |
Adefovir dipivoxil monotherapy is a sufficiently effective treatment modality for Japanese patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome | 2006 |
Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Case-Control Studies; DNA, Viral; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Pharmacogenetics; Probability; Reverse Transcriptase Polymerase Chain Reaction; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome; Viral Load | 2006 |
[The change of HBV nucleotide sequence during Adefovir dipivoxil treatment].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Point Mutation; Sequence Analysis, DNA | 2006 |
[The use of nucleotide analogues in treating patients with chronic hepatitis B].
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2006 |
[Problems of and strategies in nucleotide analogues therapy for chronic hepatitis B].
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2006 |
American Association for Cancer Research--97th annual meeting.
Topics: Adenine; Animals; Antineoplastic Agents; Benzoquinones; Glioblastoma; HSP90 Heat-Shock Proteins; Humans; Indoles; Janus Kinase 2; Lactams, Macrocyclic; Neoplasms, Experimental; Organophosphonates; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Topotecan; Tyrphostins | 2006 |
Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2).
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Microbial Sensitivity Tests; Mutation; Nucleic Acid Hybridization; Oligonucleotide Probes; Organophosphonates; Reagent Kits, Diagnostic; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Sequence Analysis, DNA | 2006 |
[To evaluate treatments of chronic hepatitis B].
Topics: Adenine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates | 2006 |
[Comparison of clinical outcome between patients continuing and discontinuing lamivudine therapy in acute exacerbation after viral breakthrough during lamivudine therapy in chronic hepatitis B].
Topics: Acute Disease; Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2006 |
Adefovir dipivoxyl for the treatment of delta-related liver cirrhosis.
Topics: Adenine; Female; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Liver Cirrhosis; Middle Aged; Organophosphonates | 2006 |
Temporary HBV resolution in an HIV-coinfected patient during HBV-directed combination therapy followed by relapse of HBV.
Topics: Adenine; Adult; Antiviral Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; HIV Infections; HIV-1; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Secondary Prevention; Viral Load | 2006 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses | 2007 |
[A case of severe skin eruption caused by lamivudine in a patient with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Eruptions; Female; Hepatitis B, Chronic; Humans; Ichthyosis; Lamivudine; Middle Aged; Organophosphonates | 2006 |
Treatment of lamivudine-resistant hepatitis B infection in post-renal transplant patients with adefovir dipivoxil: preliminary results.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Follow-Up Studies; Hepatitis B; Hepatitis B Core Antigens; Humans; Kidney; Kidney Transplantation; Lamivudine; Middle Aged; Organophosphonates; Postoperative Complications | 2006 |
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Topics: Adenine; Bacteria; Cell Membrane; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Liver; Metabolic Detoxication, Phase I; Models, Biological; NADPH-Ferrihemoprotein Reductase; Organophosphonates; Oxygenases; Research Design; Tenofovir; Transformation, Bacterial | 2006 |
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Organophosphonates; Prodrugs; Tenofovir | 2006 |
Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; CD4 Lymphocyte Count; Cell Division; Cells, Cultured; Female; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-gamma; Interleukin-10; Male; Middle Aged; Organophosphonates; T-Cell Antigen Receptor Specificity; T-Lymphocytes; T-Lymphocytes, Regulatory; Viral Load | 2007 |
[The rate of hepatitis B virus resistance to adefovir dipivoxil (ADV) and the evolution of hepatitis B virus in lamivudine-resistant chronic hepatitis B patients with ADV monotherapy].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2007 |
[Autoimmune thrombopenia associated with hepatitis B reactivation (reverse seroconversion) after autologous hematopoietic stem cell transplantation].
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Hematopoietic Stem Cell Transplantation; Hepatitis B; Humans; Immunocompromised Host; Immunoglobulin G; Immunologic Factors; Lymphoma; Male; Middle Aged; Organophosphonates; Purpura, Thrombocytopenic, Idiopathic; Recurrence; Transplantation, Autologous; Treatment Outcome | 2007 |
Why do we not yet have combination chemotherapy for chronic hepatitis B?
Topics: Adenine; Antibodies, Viral; Antiviral Agents; DNA, Viral; Drug Combinations; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Drug Synergism; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2007 |
Antiviral therapy for pre- and post-liver transplantation patients with hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Humans; Kidney Diseases; Lamivudine; Liver Transplantation; Organophosphonates; Secondary Prevention; Tenofovir | 2007 |
Progress in the treatment of chronic hepatitis B: long-term experience with adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Phenotype | 2007 |
Treatment of patients with lamivudine-resistant and adefovir dipivoxil-resistant chronic hepatitis B virus infection: is tenofovir the answer?
Topics: Adenine; Adult; Drug Resistance, Multiple, Viral; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Hong Kong; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2007 |
Adefovir dipivoxil monotherapy and combination therapy with lamivudine for the treatment of chronic hepatitis B in an Asian population.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Asian People; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Hong Kong; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2007 |
Evolution of viral load and changes of polymerase and precore/core promoter sequences in lamivudine-resistant hepatitis B virus during adefovir therapy.
Topics: Adenine; Adult; Antiviral Agents; Base Sequence; DNA Mutational Analysis; DNA Primers; DNA, Viral; Drug Resistance, Viral; Evolution, Molecular; Female; Gene Products, pol; Genes, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Promoter Regions, Genetic; Viral Core Proteins; Viremia | 2007 |
Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors | 2007 |
[Recent advances in the treatment of the hepatitis HBV-related. Effectiveness and tolerability of adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Treatment Outcome | 2007 |
In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Transfection; Viral Proteins | 2007 |
Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Clinical Trials as Topic; DNA Mutational Analysis; Drug Resistance, Viral; Female; Gene Products, pol; Hepatitis B; Hepatitis B virus; Humans; Male; Mutation; Organophosphonates; Polymorphism, Genetic | 2007 |
Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2007 |
A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
Topics: Adenine; Adult; Arabinofuranosyluracil; Base Sequence; Cell Line, Tumor; Cloning, Molecular; Deoxycytidine; DNA Mutational Analysis; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Viral; Emtricitabine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Transfection; Treatment Outcome; Viral Load; Virus Replication | 2007 |
Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
Topics: Adenine; Analytic Sample Preparation Methods; Borates; Chromatography, Gas; Drug Contamination; Imidazoles; Ionic Liquids; Organophosphonates; Pharmaceutical Preparations; Reproducibility of Results; Sensitivity and Specificity; Solvents; Temperature; Ultrasonics; Volatilization | 2007 |
Prophylaxis of hepatitis B recurrence in post-liver transplantation patients with lamivudine-resistant YMDD mutant.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Hepatitis B; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Recurrence | 2007 |
Summaries for patients. Antiviral therapy for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine; Viral Load | 2007 |
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
Topics: Adenine; Amino Acid Substitution; Drug Resistance, Viral; Evolution, Molecular; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation, Missense; Nucleic Acid Hybridization; Organophosphonates; Sequence Analysis, DNA; Time Factors | 2007 |
The cost-effectiveness of long-term antiviral therapy in the management of HBeAg-positive and HBeAg-negative chronic hepatitis B in Singapore.
Topics: Adenine; Antiviral Agents; Asian People; Cost-Benefit Analysis; Drug Costs; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Markov Chains; Models, Economic; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Singapore | 2007 |
Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Statistics, Nonparametric | 2008 |
Hepatitis B virus containing the I233V mutation in the polymerase reverse-transcriptase domain remains sensitive to inhibition by adefovir.
Topics: Adenine; Adult; Aged; Antiviral Agents; Clinical Trials, Phase III as Topic; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Randomized Controlled Trials as Topic; RNA-Directed DNA Polymerase | 2007 |
Adefovir dipivoxil therapy in liver transplant recipients for recurrence of hepatitis B virus infection despite lamivudine plus hepatitis B immunoglobulin prophylaxis.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Serologic Tests | 2007 |
[Protocol for the treatment of chronic viral hepatitis].
Topics: Adenine; Algorithms; Antiviral Agents; Clinical Protocols; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin | 2008 |
Lamivudine-resistant chronic hepatitis B: an observational study on adefovir in monotherapy or in combination with lamivudine.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Prospective Studies; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2008 |
Adefovir and lamivudine in combination compared with adefovir monotherapy in HBeAg-negative adults with chronic hepatitis B virus infection and clinical or virologic resistance to lamivudine: a retrospective, multicenter, nonrandomized, open-label study.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multicenter Studies as Topic; Organophosphonates; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load | 2008 |
[Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymorphism, Restriction Fragment Length | 2008 |
Severe acute pancreatitis related to the use of adefovir in a liver transplant recipient.
Topics: Acute Disease; Adenine; Aged; Antiviral Agents; Hepatitis B; Humans; Liver Transplantation; Male; Organophosphonates; Pancreatitis; Postoperative Complications; Recurrence | 2008 |
[The predictive value of ALT, HBeAg and HBV DNA levels at baseline and the degree of HBV suppression at week 12 adefovir dipivoxil treatment to the efficacy of it at week 52 in patients with HBeAg-positive chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Predictive Value of Tests; Treatment Outcome; Young Adult | 2008 |
Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy.
Topics: Adenine; Amines; Antiviral Agents; Cell Line; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glycerides; Hepatitis B virus; Humans; Nanoparticles; Nanotechnology; Organophosphonates | 2008 |
[Comparison of antiviral responses to adefovir dipivoxil therapy of genotype B and genotype C HBV infected patients].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2008 |
Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV.
Topics: Adenine; Adult; Antiviral Agents; Bilirubin; Disease Progression; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Failure; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Patient Selection; Predictive Value of Tests; Prognosis; Prothrombin Time; Retrospective Studies; Treatment Outcome | 2008 |
Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after lamivudine retreatment.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Male; Middle Aged; Mutation; Organophosphonates; Time Factors | 2008 |
Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infection.
Topics: Adenine; Animals; Antigens, Viral; Antiviral Agents; Deoxycytidine; Disease Models, Animal; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Marmota; Organophosphonates; RNA, Viral; Rodent Diseases; Tenofovir; Virus Replication | 2008 |
Adefovir dipivoxil is effective for the treatment of cirrhotic patients with lamivudine failure.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Cohort Studies; Drug Resistance; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2009 |
[A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus].
Topics: Absorptiometry, Photon; Adenine; Adult; Antiviral Agents; Bone Density; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Tomography, X-Ray Computed | 2008 |
[Construction of full-length genome HBV plasmid with adefovir dipivoxil drug-resistance gene in RT domain of polymerase].
Topics: Adenine; Drug Resistance, Viral; Genome, Viral; Hepatitis B virus; Organophosphonates; Plasmids; Viral Proteins | 2008 |
Are hepatitis B e antigen (HBeAg)-positive chronic hepatitis B and HBeAg-negative chronic hepatitis B distinct diseases?
Topics: Adenine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates | 2008 |
Sustained hepatitis B e antigen seroconversion in patients with chronic hepatitis B after adefovir dipivoxil treatment: analysis of precore and basal core promoter mutants.
Topics: Adenine; Adult; Alanine Transaminase; Asian People; DNA Mutational Analysis; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; White People | 2008 |
Hepatitis B virus genotype-associated variability in antiviral response to adefovir dipivoxil therapy in Chinese Han population.
Topics: Adenine; Adult; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Asian People; DNA, Viral; Ethnicity; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2008 |
[Protocol for the antiviral therapy of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2008 |
Chronic hepatitis B--new goals, new treatment.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Viral Load | 2008 |
[The efficacy of adefovir dipivoxil monotherapy and the incidence of genotypic resistance to adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B infection].
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA | 2008 |
Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient.
Topics: Acute Kidney Injury; Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Kidney Transplantation; Male; Middle Aged; Organophosphonates | 2009 |
A short course of add-on adefovir dipivoxil treatment in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Salvage Therapy; Sequence Analysis, DNA; Treatment Outcome; Viral Load | 2009 |
Virological response and hepatocarcinogenesis in lamivudine-resistant hepatitis B virus genotype C patients treated with lamivudine plus adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Lamivudine; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2008 |
Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.
Topics: Acyclovir; Adenine; Amides; Animals; Antihypertensive Agents; Antiviral Agents; Area Under Curve; Bimatoprost; Biological Transport; Cell Line; Cloprostenol; Cornea; Dogs; Dose-Response Relationship, Drug; Epithelium, Corneal; Humans; Latanoprost; Male; Multidrug Resistance-Associated Proteins; Permeability; Propionates; Prostaglandins F, Synthetic; Quinolines; Rabbits; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Gene Products, pol; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Recovery of Function; Viral Load; Young Adult | 2009 |
[Virologic response to adefovir dipivoxil monotherapy is not durable in HBeAg-positive, lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Risk Factors | 2009 |
Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Viral Load | 2009 |
Current trends in chronic hepatitis B management: results of a questionnaire.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; Clinical Competence; Drug Administration Schedule; Family Health; Guanine; Hepatitis B e Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver; Male; Middle Aged; Organophosphonates; Practice Patterns, Physicians'; Spain; Surveys and Questionnaires | 2009 |
Rapid HBV DNA decrease (week 12) is an important prognostic factor for first-line treatment with adefovir dipivoxil for chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Viral Load | 2009 |
[The clinical study of adding on adefovir dipivoxil to treat for lamivudine resistant patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2009 |
Renal dysfunction in chronic hepatitis B patients treated with adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2009 |
Monitoring of therapy in patients with chronic hepatitis B virus.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Monitoring; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Point Mutation; Sequence Analysis, DNA | 2010 |
Dynamic changes of HBV quasispecies and deletion patterns in a chronic hepatitis B patient.
Topics: Adenine; Antiviral Agents; Cluster Analysis; DNA, Viral; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Phylogeny; Sequence Analysis, DNA; Sequence Deletion; Sequence Homology; Viral Proteins | 2009 |
Detection of the rtA181V/T and rtN236T mutations associated with resistance to adefovir dipivoxil using a ligase detection reaction assay.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Ligases; Mutation; Organophosphonates; Plasmids; RNA-Directed DNA Polymerase | 2009 |
Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Creatinine; DNA, Viral; Drug Resistance, Viral; Fanconi Syndrome; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney; Lamivudine; Male; Middle Aged; Organophosphonates; Phosphates; Renal Insufficiency; Serum; Treatment Outcome; Viral Load | 2010 |
Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil.
Topics: Adenine; Animals; Antiviral Agents; Biological Transport; Caco-2 Cells; Cell Line; Dogs; Humans; Intestinal Absorption; Kidney; Multidrug Resistance-Associated Proteins; Organophosphonates | 2010 |
[Non-standard discontinuation of adefovir dipivoxil causing acute exacerbation of hepatitis].
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Critical Illness; Cytokines; DNA, Viral; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphocyte Count; Male; Organophosphonates; Recurrence; T-Lymphocytes; Time Factors; Treatment Outcome | 2009 |
[The efficacy of nucleoside/nucleotide analogue on chronic hepatitis B].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2009 |
[Dissection of mechanism for the adefovir dipivoxil resistance in chronic hepatitis B patients].
Topics: Adenine; Adult; Alanine Transaminase; Amino Acid Sequence; Antiviral Agents; Base Sequence; DNA Primers; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Molecular Sequence Data; Organophosphonates; Polymorphism, Genetic; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Sequence Analysis, DNA | 2009 |
Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Design; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2009 |
Serum levels of surface large envelope proteins: prognostic markers for hepatitis B e antigen-negative patients with adefovir dipivoxil treatment.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Membrane Proteins; Middle Aged; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; ROC Curve; Treatment Outcome | 2009 |
Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Hypophosphatemia; Magnetic Resonance Imaging; Male; Organophosphonates; Osteomalacia | 2010 |
Evolution of full-length HBV sequences in chronic hepatitis B patients with sequential lamivudine and adefovir dipivoxil resistance.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Evolution, Molecular; Female; Gene Products, pol; Genome, Viral; Genotype; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Phylogeny; Reverse Transcriptase Inhibitors; Young Adult | 2010 |
Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern.
Topics: Adenine; Adolescent; Adult; Aged; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Point Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Young Adult | 2011 |
Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Emulsions; Enzyme Inhibitors; Esterases; Inhibitory Concentration 50; Intestinal Absorption; Intestinal Mucosa; Male; Oleic Acids; Organophosphonates; Rats; Rats, Sprague-Dawley; Triglycerides | 2010 |
rtE218G, a novel hepatitis B virus mutation with resistance to adefovir dipivoxil in patients with chronic hepatitis B.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Cell Line; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Mutation, Missense; Organophosphonates; RNA-Directed DNA Polymerase; Sequence Analysis, DNA | 2010 |
Lamivudine-resistance mutations can be selected even at very low levels of hepatitis B viraemia.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load; Viremia | 2010 |
[Resistance mutation patterns of hepatitis B virus in patients with suboptimal response to adefovir dipivoxil therapy after lamivudine resistance].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2010 |
[A case of osteomalacia related to adefovir in a patient with chronic hepatitis B].
Topics: Adenine; Aged; Alkaline Phosphatase; Antiviral Agents; Dietary Supplements; DNA, Viral; Hepatitis B, Chronic; Humans; Hypophosphatemia; Liver Cirrhosis; Male; Organophosphonates; Osteomalacia; Phosphates; Whole Body Imaging | 2010 |
Cost-utility analysis of tenofovir disoproxil fumarate in the treatment of chronic hepatitis B.
Topics: Adenine; Cost-Benefit Analysis; Guanine; Hepatitis B, Chronic; Humans; Markov Chains; Organophosphonates; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; State Medicine; Tenofovir; United Kingdom | 2010 |
HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Catheter Ablation; Disease-Free Survival; Female; Guanine; Hepatectomy; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Kaplan-Meier Estimate; Lamivudine; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Organophosphonates; Proportional Hazards Models; Risk Assessment; Risk Factors; RNA, Viral; Survival Rate; Time Factors; Treatment Outcome | 2010 |
Treatment of children with chronic hepatitis B virus infection in the United States: patient selection and therapeutic options.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Drug Resistance, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Patient Selection; Recombinant Proteins | 2010 |
Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Case-Control Studies; Cytokines; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunomodulation; Lamivudine; Male; Middle Aged; Organophosphonates; T-Lymphocytes, Regulatory; Th1-Th2 Balance | 2011 |
Initial virological response and viral mutation with adefovir dipivoxil added to ongoing Lamivudine therapy in Lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome | 2011 |
Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Biopsy; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome; Virus Replication; Young Adult | 2011 |
Efficacy and pharmacokinetics of adefovir dipivoxil liquid suspension in patients with chronic hepatitis B and renal impairment.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Pharmaceutical Solutions; Renal Insufficiency; Treatment Outcome | 2011 |
[Analogs combination therapy in chronic hepatitis B: when and how?].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2010 |
Th1 and Th2 immune response in chronic hepatitis B patients during a long-term treatment with adefovir dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; Clinical Trials as Topic; Cytokines; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Th1 Cells; Th2 Cells | 2010 |
Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; China; Cross-Sectional Studies; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Typing; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Young Adult | 2010 |
Evolution and suppression of HBV strains with multidrug resistance to lamivudine, adefovir dipivoxil and entecavir in a patient with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Evolution, Molecular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Organophosphonates; Phylogeny; Recombinant Proteins; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome | 2010 |
HBV core region variability: effect of antiviral treatments on main epitopic regions.
Topics: Adenine; Adult; Amino Acid Sequence; Antigenic Variation; Antiviral Agents; B-Lymphocytes; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunodominant Epitopes; Interferons; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Polymorphism, Genetic; T-Lymphocytes | 2011 |
Comparison of multiplex restriction fragment mass polymorphism and sequencing analyses for detecting entecavir resistance in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mass Spectrometry; Mutation; Organophosphonates; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Viral Load | 2011 |
Medication nonadherence with long-term management of patients with hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Cohort Studies; Community Health Services; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2011 |
[Virological response to adefovir dipivoxil predicts the long-term development of resistance in previously untreated patients with HBeAg-negative chronic hepatitis B].
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Time Factors; Young Adult | 2011 |
Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation.
Topics: Adenine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Organophosphonates; Saccharin; Solubility | 2011 |
Modeling of autocatalytic hydrolysis of adefovir dipivoxil in solid formulations.
Topics: Adenine; Catalysis; Chemistry, Pharmaceutical; Dosage Forms; Drug Stability; Hydrolysis; Neural Networks, Computer; Organophosphonates; Prodrugs | 2011 |
[The replication capacity and drug sensitivity of Adefovir dipivoxil-resistant HBV mutants in vivo].
Topics: Adenine; Animals; Antiviral Agents; Base Sequence; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Organophosphonates | 2011 |
Long-term add-on therapy with adefovir in lamivudine-resistant kidney graft recipients with chronic hepatitis B.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Survival Rate; Time Factors; Treatment Outcome | 2011 |
Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Aged; Amino Acid Substitution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Gene Products, pol; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load; Young Adult | 2011 |
Parallel decline of CD8+CD38+ lymphocytes and viremia in treated hepatitis B patients.
Topics: Adenine; ADP-ribosyl Cyclase 1; Adult; CD3 Complex; Female; Hepatitis B, Chronic; Humans; Male; Membrane Glycoproteins; Middle Aged; Organophosphonates; T-Lymphocyte Subsets; Viremia | 2011 |
Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose?
Topics: Adenine; Aged; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Organophosphonates | 2012 |
High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B.
Topics: Adaptive Immunity; Adenine; Adult; Alanine Transaminase; Animals; Antiviral Agents; Aspartate Aminotransferases; CD4 Antigens; Cytokines; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Organophosphonates; Receptors, CXCR5; T-Lymphocytes, Helper-Inducer; Young Adult | 2011 |
Frequency and risk factors of renal impairment during long-term adefovir dipivoxil treatment in chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Incidence; Kaplan-Meier Estimate; Kidney; Kidney Diseases; Lamivudine; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Organophosphonates; Proportional Hazards Models; Republic of Korea; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2012 |
rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy.
Topics: Adenine; Biomarkers; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Multivariate Analysis; Mutation; Organophosphonates; Phenotype; Proportional Hazards Models; Republic of Korea; Reverse Transcriptase Inhibitors; Risk Assessment; Risk Factors; RNA-Directed DNA Polymerase; Time Factors; Viral Load | 2012 |
High dose lamivudine in HBV-related cirrhotic patients with unsatisfactory response after adefovir add-on.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Failure; Viral Load; Virus Replication | 2012 |
Optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment HBV DNA: a 5-year prospective study.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; China; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Treatment Outcome | 2011 |
[A case with poly-bone pain, decrease of bone density and in crease of serum creatinine related to adefovir dipivoxil treatment in a chronic hepatitis B patient].
Topics: Adenine; Adult; Bone Density; Creatinine; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Pain; Phosphorus | 2011 |
Adefovir dipivoxil modulates cytokine expression in Th1/Th2 cells in patients with chronic hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Cytokines; DNA, Viral; Female; Gene Expression Regulation; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Th1 Cells; Th2 Cells; Time Factors | 2012 |
Novel polymorphic form of adefovir dipivoxil derived from polymer-directed crystallization.
Topics: Adenine; Antiviral Agents; Calorimetry, Differential Scanning; Crystallization; Microscopy, Electron, Scanning; Models, Molecular; Organophosphonates; Particle Size; Polymers; Powders; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2011 |
[Lamivudine-resistant analysis and management for chronic hepatitis B patients with initial lamivudine therapy].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2011 |
[HBV resistance mutants before and after adefovir dipivoxil treatment and the relationship with HBV genotypes].
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Genes, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates | 2011 |
Molecular characterization of a novel entecavir mutation pattern isolated from a multi-drug refractory patient with chronic hepatitis B infection.
Topics: Adenine; Adult; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Fatal Outcome; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Mutation; Organophosphonates; Virus Replication | 2012 |
Polymorphic and kinetic investigation of adefovir dipivoxil during phase transformation.
Topics: Adenine; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Kinetics; Models, Chemical; Organophosphonates; Phase Transition; Powder Diffraction; Reverse Transcriptase Inhibitors; Solubility; Technology, Pharmaceutical; Thermogravimetry; Transition Temperature | 2012 |
[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Muscle Weakness; Organophosphonates; Osteomalacia; Young Adult | 2011 |
De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2011 |
Transarterial chemoembolization for hepatitis B virus-associated hepatocellular carcinoma: improved survival after concomitant treatment with nucleoside analogues.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Chi-Square Distribution; Disease-Free Survival; Female; Guanine; Hepatitis B, Chronic; Humans; Japan; Kaplan-Meier Estimate; Lamivudine; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Nucleosides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Time Factors; Treatment Outcome | 2012 |
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Nucleic Acid Hybridization; Organophosphonates; Sequence Analysis, DNA | 2012 |
Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B.
Topics: Adenine; Adult; Enzyme-Linked Immunosorbent Assay; Female; Hep G2 Cells; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interleukin-33; Interleukins; Liver; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.
Topics: Adenine; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cells, Cultured; Drug Interactions; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organophosphonates; Permeability; Verapamil; Vitamin D | 2012 |
Commentary: combination therapy with two nucleos(t)ide analogues in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations.
Topics: Adenine; Antiviral Agents; Capsid Proteins; DNA, Viral; Drug Resistance, Viral; Hep G2 Cells; Hepatitis B virus; Humans; Inhibitory Concentration 50; Mutation; Organophosphonates; Pyrimidines; Thiazoles; Viral Core Proteins; Virus Assembly; Virus Replication | 2012 |
Solid lipid nanoparticles and nanosuspension of adefovir dipivoxil for bioavailability improvement: formulation, characterization, pharmacokinetic and biodistribution studies.
Topics: Adenine; Animals; Biological Availability; Calorimetry, Differential Scanning; Drug Carriers; Female; Lipids; Male; Mice; Microscopy, Electron, Transmission; Nanoparticles; Organophosphonates; Particle Size; Reverse Transcriptase Inhibitors; Solubility; X-Ray Diffraction | 2013 |
[Influence of adefovir dipivoxil or telbivudine monotherapy on renal function of patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Young Adult | 2012 |
Current practice of chronic hepatitis B treatment in Southern Italy.
Topics: Adenine; Adult; Age Factors; Aged; Aged, 80 and over; Antiviral Agents; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Italy; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Polyethylene Glycols; Practice Patterns, Physicians'; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Young Adult | 2012 |
Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Cells, Cultured; DNA, Viral; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-gamma; Interleukin-1; Lamivudine; Organophosphonates; T-Lymphocytes; Tenofovir; Tumor Necrosis Factor-alpha | 2012 |
Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cloning, Molecular; DNA, Viral; Drug Resistance, Viral; Drug Substitution; Escherichia coli; Evolution, Molecular; Female; Follow-Up Studies; Gene Products, pol; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Viremia | 2012 |
Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report.
Topics: Adenine; Antiviral Agents; Arthroplasty, Replacement, Hip; Fanconi Syndrome; Femoral Neck Fractures; Hepatitis B, Chronic; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Osteomalacia; Predictive Value of Tests; Radiography; Radiopharmaceuticals; Treatment Outcome; Whole Body Imaging | 2012 |
Hepatitis B e antigen predicts delayed reduction of HBV DNA without viral breakthrough with adefovir dipivoxil and lamivudine: a 5-year study of patients with hepatitis B with lamivudine resistance.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2012 |
Comparison of rescue strategies in lamivudine-resistant patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; China; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Salvage Therapy; Treatment Outcome | 2012 |
Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals.
Topics: Adenine; Antiviral Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Crystallization; Drug Stability; Niacinamide; Organophosphonates; Powder Diffraction; Prodrugs; Saccharin; Solubility; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction | 2012 |
2D solid-state NMR analysis of inclusion in drug-cyclodextrin complexes.
Topics: Adenine; Carbon Radioisotopes; Cyclodextrins; Diflunisal; Fluorine Radioisotopes; Hydrogen; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Phosphorus; Pyrimidines; Triazoles; Voriconazole | 2012 |
Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy.
Topics: Adenine; Administration, Oral; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Genes, pol; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Mutation Rate; Organophosphonates; Prevalence; Virus Replication | 2012 |
Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients: a propensity score analysis.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; alpha-Fetoproteins; Antiviral Agents; Child; Child, Preschool; Female; Follow-Up Studies; Guanine; Hepatitis B Core Antigens; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Proportional Hazards Models | 2013 |
[Clinical analysis of hepatitis B virus mutations related to adefovir dipivoxil among patients with chronic hepatitis B virus infection in eastern Zhejiang province].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Young Adult | 2012 |
Treatment of lamivudine-resistant chronic hepatitis B infection: a multicenter retrospective study.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Treatment Outcome; Viral Load | 2013 |
[Assessment of mitochondrial toxicity induced by zidovudine and adefovir dipivoxil in rats].
Topics: Adenine; Animals; DNA, Mitochondrial; Electron Transport Complex IV; Female; Kidney; Liver; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Mitochondria, Muscle; Muscle, Skeletal; Myocardium; Organophosphonates; Rats; Rats, Sprague-Dawley; Zidovudine | 2012 |
[Outcomes of unexpected pregnancy during anti-hepatitis B virus therapy with adefovir dipivoxil: a report on safety and full-term infants].
Topics: Adenine; Adult; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Male; Organophosphonates; Pregnancy; Pregnancy Trimesters | 2012 |
Osteomalacia due to Fanconi's syndrome and renal failure caused by long-term low-dose adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia; Renal Insufficiency | 2013 |
Hepatitis B virus wild-type and rtN236T populations show similar early HBV DNA decline in adefovir refractory patients on a tenofovir-based regimen.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Gene Products, pol; Genetic Association Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Male; Middle Aged; Molecular Typing; Organophosphonates; Polymerase Chain Reaction; Randomized Controlled Trials as Topic; Sequence Analysis, DNA; Tenofovir; Treatment Outcome; Viral Load; Virus Replication | 2013 |
Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Gene Products, pol; Hepatitis B e Antigens; Hepatitis B virus; Humans; Mutation; Organophosphonates; Promoter Regions, Genetic; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2013 |
Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Mutation; Organophosphonates; Probability; Retrospective Studies; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome | 2012 |
Adefovir is effective to promote development of immunity to donor origin hepatitis B virus in an allogeneic transplant recipient: a case report.
Topics: Adenine; Adult; Alanine Transaminase; Anemia, Aplastic; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; DNA, Viral; Donor Selection; Drug Resistance, Viral; Drug Therapy, Combination; Hematopoietic Stem Cell Transplantation; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Lamivudine; Living Donors; Male; Organophosphonates; Time Factors; Transplantation, Homologous; Treatment Outcome | 2013 |
Characterization of the dynamics of hepatitis B virus resistance to adefovir by ultra-deep pyrosequencing.
Topics: Adenine; Adolescent; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult | 2013 |
Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Hypophosphatemia; Incidence; Kidney Diseases; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Risk Factors; Time Factors | 2014 |
[Three-year efficacy and side effect of adefovir dipivoxil for the treatment of the old patients with chronic hepatitis B virus infection].
Topics: Adenine; Aged; Aged, 80 and over; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Time Factors | 2012 |
Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition.
Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia | 2013 |
[Genotypes and evolution characteristics of three patients with poor response to initial treatment of Lamivudine and Adefovir dipivoxil for hepatitis].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Genetic Drift; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2012 |
[Treatment of one advanced schistosomiasis patient with hepatitis B cirrhosis by lamivudine and adefovir dipivoxil].
Topics: Adenine; Adult; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Schistosomiasis | 2013 |
[The observation of blood serum creatinine and phosphorus during long-term adefovir dipivoxil treatment in chronic hepatitis].
Topics: Adenine; Adolescent; Adult; Aged; Creatinine; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phosphorus; Retrospective Studies; Young Adult | 2013 |
[Hypophosphatemia and chest pain related to adefovir dipivoxil treatment for chronic hepatitis B: report of two cases].
Topics: Adenine; Chest Pain; Female; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Young Adult | 2013 |
Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Anti-Bacterial Agents; Bordetella pertussis; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Macrophages; Mice; Microbial Sensitivity Tests; Organophosphonates; Prodrugs | 2014 |
In vitro evaluation of 9-(2-phosphonylmethoxyethyl)adenine ester analogues, a series of anti-HBV structures with improved plasma stability and liver release.
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Drug Liberation; Drug Stability; Esters; Hepatitis B virus; In Vitro Techniques; Liver; Molecular Structure; Organophosphonates; Rats; Spectrometry, Mass, Electrospray Ionization | 2014 |
Thermodynamic and kinetic investigation on the crucial factors affecting adefovir dipivoxil-saccharin cocrystallization.
Topics: Adenine; Antiviral Agents; Crystallization; Kinetics; Organophosphonates; Phase Transition; Powder Diffraction; Saccharin; Solubility; Thermodynamics; X-Ray Diffraction | 2014 |
Experimental and molecular docking studies on DNA binding interaction of adefovir dipivoxil: advances toward treatment of hepatitis B virus infections.
Topics: Absorption; Adenine; Animals; Cattle; Circular Dichroism; DNA; Electrons; Hepatitis B; Hepatitis B virus; Kinetics; Ligands; Molecular Docking Simulation; Organophosphonates; Spectrometry, Fluorescence; Viscosity | 2014 |
[The clinical significance of hepatitis B virus large surface protein in the diagnosis and treatment of patients with hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Young Adult | 2013 |
Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
Topics: Adenine; Adult; Alleles; Antiviral Agents; DNA Primers; DNA, Viral; Drug Resistance, Viral; Early Diagnosis; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Isoleucine; Lamivudine; Limit of Detection; Male; Middle Aged; Molecular Sequence Data; Mutation; Nucleotide Motifs; Oligonucleotides; Organophosphonates; Real-Time Polymerase Chain Reaction | 2014 |
Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression.
Topics: Adenine; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Organophosphonates; Real-Time Polymerase Chain Reaction; Tenofovir | 2014 |
Fanconi syndrome caused by low-dose adefovir dipivoxil.
Topics: Adenine; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors | 2014 |
Screening and identification of a novel adefovir dipivoxil resistance associated mutation, rtN236V, of HBV from a large cohort of HBV-infected patients.
Topics: Adenine; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Codon; DNA, Viral; Drug Resistance, Viral; Female; Genes, Viral; Genotype; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Time Factors; Viral Load; Virus Replication | 2014 |
Decline in intrahepatic cccDNA and increase in immune cell reactivity after 12 weeks of antiviral treatment were associated with HBeAg loss.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Enzyme-Linked Immunospot Assay; Female; Hepatitis B Antigens; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunohistochemistry; Interferon-gamma; Killer Cells, Natural; Liver; Male; Organophosphonates; Real-Time Polymerase Chain Reaction; T-Lymphocytes; Viral Load; Young Adult | 2014 |
Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2014 |
The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Genes, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication; Young Adult | 2015 |
[Case report; Fanconi's syndrome and hypophosphatemic osteomalacia associated with adefovir dipivoxil: a case report].
Topics: Adenine; Aged; Antiviral Agents; Fanconi Anemia; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia; Treatment Outcome | 2014 |
Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Glomerulonephritis; Glucocorticoids; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nephrotic Syndrome; Organophosphonates; Treatment Outcome; Young Adult | 2014 |
[Clinical pathology of recurrent hepatitis B after liver transplantation].
Topics: Adenine; Antiviral Agents; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Recurrence | 2014 |
Discovering novel direct acting antiviral agents for HBV using in silico screening.
Topics: Adenine; Albumins; Animals; Antiviral Agents; Binding Sites; Cells, Cultured; Chimera; Databases, Protein; Drug Design; Drug Discovery; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Ligands; Liver; Mice; Middle Aged; Molecular Docking Simulation; Organophosphonates; Protein Binding; Real-Time Polymerase Chain Reaction; Tenofovir | 2015 |
Efficacy of adefovir dipivoxil therapy in patients with chronic hepatitis B viral infection.
Topics: Adenine; Adult; Antiviral Agents; Bangladesh; Drug Monitoring; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Function Tests; Male; Middle Aged; Monitoring, Immunologic; Organophosphonates; Prospective Studies; Treatment Outcome | 2014 |
Nucleotide analogue-resistant mutations in hepatitis B viral genomes found in hepatitis B patients.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Genome, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates | 2015 |
Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates.
Topics: Adenine; Adult; Antiviral Agents; Chi-Square Distribution; Cross-Sectional Studies; Diagnostic Imaging; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Mutation; Organophosphonates; Predictive Value of Tests; Risk Factors; Time Factors; Treatment Outcome | 2014 |
[Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Treatment Outcome | 2014 |
Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing.
Topics: Adenine; Cell Line; Epithelium; Gene Expression Regulation; Humans; Hypoxia; Kidney Diseases; Kidney Tubules, Proximal; Organophosphonates; Oxygen; Protein Array Analysis; Reverse Transcriptase Inhibitors; Toxicity Tests; Xenobiotics | 2015 |
Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.
Topics: Adenine; Administration, Oral; Antiviral Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Desiccation; Drug Stability; Organophosphonates; Powder Diffraction; Technology, Pharmaceutical; Transition Temperature; Volatilization; Water | 2015 |
[The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis].
Topics: Adenine; Adult; Antirheumatic Agents; Biomarkers; C-Reactive Protein; Fanconi Syndrome; Female; Humans; Hyperparathyroidism; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Platelet Count; Prognosis; Sjogren's Syndrome; Spondylarthritis; Young Adult | 2014 |
Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B.
Topics: Adenine; Adult; Age Factors; Aged; Aged, 80 and over; Antiviral Agents; Chi-Square Distribution; Female; Genetic Predisposition to Disease; Hepatitis B, Chronic; Humans; Japan; Kidney Diseases; Kidney Tubules, Proximal; Logistic Models; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Odds Ratio; Organic Anion Transport Protein 1; Organophosphonates; Osteomalacia; Polymorphism, Single Nucleotide; Prevalence; Retrospective Studies; Risk Factors; Time Factors | 2015 |
Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Calcium; Dose-Response Relationship, Drug; Drug Monitoring; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Musculoskeletal Pain; Organophosphonates; Osteomalacia; Phosphates; Time Factors | 2015 |
[Pharmacoeconomic evaluation of treatments based on antiretrovirals for HBeAg-negative chronic hepatitis B].
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Economics, Pharmaceutical; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Quality-Adjusted Life Years; Recombinant Proteins | 2015 |
Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA Replication; DNA, Viral; Drug Therapy, Combination; Female; Glomerulonephritis; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Proteinuria; Young Adult | 2015 |
Low-dose adefovir dipivoxil may induce Fanconi syndrome: clinical characteristics and long-term follow-up for Chinese patients.
Topics: Adenine; Adult; Alkaline Phosphatase; Antiviral Agents; Asian People; Bone Density; Creatinine; Drug Administration Schedule; Fanconi Syndrome; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Phosphates; Retrospective Studies | 2015 |
Efficacy of tenofovir switch therapy for nucleos(t)ide-experienced patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2015 |
Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B.
Topics: Acute Kidney Injury; Adenine; Adult; Antiviral Agents; beta 2-Microglobulin; Biomarkers; Case-Control Studies; Creatinine; Drug Substitution; Female; Glomerular Filtration Rate; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Prospective Studies; Retinol-Binding Proteins; Risk Factors; Time Factors; Treatment Outcome | 2015 |
The expression of TLR-9, CD86, and CD95 phenotypes in circulating B cells of patients with chronic viral hepatitis B or C before and after antiviral therapy.
Topics: Adenine; Adult; Aged; Antibodies, Monoclonal; Antiviral Agents; B-Lymphocytes; B7-2 Antigen; DNA, Viral; fas Receptor; Female; Flow Cytometry; Genotype; Hepatitis B, Chronic; Hepatitis C, Chronic; Homeostasis; Humans; Immunoglobulin D; Leukocytes, Mononuclear; Male; Middle Aged; Oligodeoxyribonucleotides; Organophosphonates; Phenotype; Prevalence; Toll-Like Receptor 9; Viral Load; Young Adult | 2015 |
A novel baseline hepatitis B virus sequencing-based strategy for predicting adefovir antiviral response.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Organophosphonates; Reproducibility of Results; ROC Curve; Sequence Analysis, DNA; Treatment Outcome; Viral Load; Young Adult | 2015 |
Initial combination anti-viral therapy with lamivudine and adefovir dipivoxil decreases short-term fatality rate of hepatitis-B-virus-related acute-on-chronic liver failure.
Topics: Acute-On-Chronic Liver Failure; Adenine; Adolescent; Adult; Aged; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Survival Analysis; Treatment Outcome; Young Adult | 2015 |
Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Organophosphonates; Sequence Analysis, DNA; Young Adult | 2015 |
[Efficacy and safety of telbivudine alone and combined with adefovir for the treatment of nucleos(t)ide-naive chronic hepatitis B in patients with high-level hepatitis B virus load].
Topics: Adenine; Alanine Transaminase; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2015 |
Osteomalacia as a Cause of Chronic Low Back and Buttock Pain.
Topics: Adenine; Adult; Antiviral Agents; Buttocks; Fractures, Spontaneous; Gait; Humans; Hypophosphatemia; Low Back Pain; Magnetic Resonance Imaging; Male; Organophosphonates; Osteomalacia; Ribs; Sacrum | 2015 |
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Binding Sites; Bordetella pertussis; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Half-Life; Humans; Male; Mice; Molecular Docking Simulation; Organophosphonates; Prodrugs; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Rats; Rats, Wistar | 2015 |
ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport, Active; Cell Division; Cell Line, Tumor; Cell Membrane; Cerebellar Neoplasms; Drug Resistance, Neoplasm; High-Throughput Screening Assays; Humans; Medulloblastoma; Mice; Mice, Knockout; Neoplasm Proteins; Propionates; Protoporphyrins; Quinolines; Topoisomerase I Inhibitors; Topotecan | 2015 |
[Clinical analysis of Fanconi syndrome induced by adefovir dipivoxil].
Topics: Adenine; Fanconi Syndrome; Humans; Organophosphonates | 2015 |
[Adefovir dipivoxil effects on and related factors of blood phosphorus metabolism in patients with chronic hepatitis B].
Topics: Adenine; Aged; Antiviral Agents; Creatinine; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Male; Organophosphonates; Phosphorus | 2015 |
Mechanism study on stability enhancement of adefovir dipivoxil by cocrystallization: Degradation kinetics and structure-stability correlation.
Topics: Adenine; Crystallization; Crystallography, X-Ray; Drug Stability; Hydrogen Bonding; Hydrolysis; Kinetics; Maleates; Organophosphonates; Powder Diffraction; Prodrugs; Salicylates; Water; X-Ray Diffraction | 2016 |
Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.
Topics: Adenine; Administration, Oral; Animals; Area Under Curve; Biological Availability; Calcitriol; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Comprehensive analysis of hospital-based prospective cohort reveals the unique effectiveness and safety for nucleos(t)ide analogues in HBV patients.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Hospitalization; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Variability in long-term hepatitis B virus dynamics under antiviral therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Humans; Interferon-alpha; Liver; Male; Models, Biological; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Viremia | 2016 |
Application of ionic liquid to polymorphic transformation of anti-viral/HIV drug adefovir dipivoxil.
Topics: Adenine; Anti-HIV Agents; Crystallization; Drug Stability; Ionic Liquids; Models, Theoretical; Organophosphonates; Phase Transition; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Transition Temperature | 2016 |
[Tetracycline-inducible replications of wild-type and an adefovir-dipivoxil-resistant hepatitis B virus in human liver cells].
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Plasmids; Tetracyclines; Transfection; Virus Replication | 2016 |
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Viral Proteins | 2016 |
Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Fanconi Syndrome; Femoral Neck Fractures; Fractures, Spontaneous; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Osteomalacia | 2016 |
Impact of FIB-4 index on hepatocellular carcinoma incidence during nucleos(t)ide analogue therapy in patients with chronic hepatitis B: An analysis using time-dependent receiver operating characteristic.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; Carcinoma, Hepatocellular; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Phosphorous Acids; Platelet Count; Proportional Hazards Models; Risk Factors; ROC Curve; Time Factors | 2017 |
Urinary β-2 Microglobulin Levels Sensitively Altered in an Osteomalacia Patient Receiving Add-on Adefovir Dipivoxil Therapy for Hepatitis B Virus Infection.
Topics: Adenine; Aged; Antiviral Agents; beta 2-Microglobulin; Female; Hepatitis B, Chronic; Humans; Japan; Organophosphonates; Osteomalacia | 2016 |
The long-term efficacy of combining nucleos(t)ide analog and low-dose hepatitis B immunoglobulin on post-transplant hepatitis B virus recurrence.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Immunoglobulins; Immunologic Factors; Kaplan-Meier Estimate; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Proportional Hazards Models; Recurrence; Retrospective Studies; Tenofovir; Treatment Outcome | 2016 |
No detectable resistance to tenofovir disoproxil fumarate in HBeAg+ and HBeAg- patients with chronic hepatitis B after 8 years of treatment.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2017 |
Osteomalacia induced by long-term low-dose adefovir dipivoxil: Clinical characteristics and genetic predictors.
Topics: Adenine; Amino Acid Sequence; Case-Control Studies; DNA Mutational Analysis; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Osteomalacia; Polymorphism, Single Nucleotide; Risk Factors; Sequence Homology, Amino Acid | 2016 |
Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Young Adult | 2016 |
Comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis B: A pilot study.
Topics: Adenine; Adult; Drug Combinations; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Pilot Projects; Tenofovir | 2016 |
Activity of Multidrug Resistance-Associated Proteins 1-5 (MRP1-5) in the RPMI 2650 Cell Line and Explants of Human Nasal Turbinate.
Topics: Adenine; Blotting, Western; Caco-2 Cells; Cell Line; Erythromycin; Humans; Immunohistochemistry; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nasal Mucosa; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; Turbinates | 2017 |
Preparation and characterization of adefovir dipivoxil-stearic acid cocrystal with enhanced physicochemical properties.
Topics: Adenine; Chemical Phenomena; Chemistry, Pharmaceutical; Microscopy, Electron, Scanning; Organophosphonates; Spectroscopy, Fourier Transform Infrared; Stearic Acids; X-Ray Diffraction | 2018 |
HBsAg loss after peginterferon-nucleotide combination treatment in chronic hepatitis B patients: 5 years of follow-up.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Sustained Virologic Response; Treatment Outcome; Young Adult | 2017 |
Adefovir dipivoxil loaded proliposomal powders with improved hepatoprotective activity: formulation, optimization, pharmacokinetic, and biodistribution studies.
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Drug Carriers; Hepatitis B; Liposomes; Male; Organophosphonates; Powders; Rats, Wistar; Tissue Distribution | 2018 |
Comparing Efficacy of Lamivudine, Adefovir Dipivoxil, Telbivudine, and Entecavir in Treating Nucleoside Analogues Naïve for HBeAg-Negative Hepatitis B with Medium Hepatitis B Virus (HBV) DNA Levels.
Topics: Adenine; Adult; Alanine Transaminase; DNA, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B e Antigens; Humans; Lamivudine; Male; Multivariate Analysis; Nucleosides; Organophosphonates; Proportional Hazards Models; Telbivudine; Thymidine | 2017 |
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Biomarkers; China; Cross-Sectional Studies; Drug Monitoring; Early Diagnosis; Female; Glomerular Filtration Rate; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Phosphorus; Predictive Value of Tests; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Time Factors | 2018 |
Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; Child, Preschool; China; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Virus Activation; Virus Replication | 2018 |
Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asian People; Female; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Young Adult | 2018 |
Clinical-features analysis on 926 patients with virological breakthrough in chronic hepatitis B receiving nucleos(t)ide analogues.
Topics: Adenine; Adult; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Medication Adherence; Organophosphonates; Reverse Transcriptase Inhibitors; Sustained Virologic Response; Telbivudine; Thymidine | 2018 |
48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse.
Topics: Adenine; Adult; Antiviral Agents; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Nucleosides; Organophosphonates; Outpatients; Prognosis; Prospective Studies; Recurrence; Risk Factors; RNA, Viral; Telbivudine; Time Factors; Treatment Outcome; Withholding Treatment | 2018 |
[Compare the effect of combined therapy between telbivudine plus adefovir dipivoxil and lamivudine plus adefovir dipivoxil corresponding to renal function in patients with hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Creatinine; DNA, Viral; Drug Therapy, Combination; Glomerular Filtration Rate; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Lamivudine; Organophosphonates; Telbivudine; Treatment Outcome | 2018 |
Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency.
Topics: Adenine; Aged; Antiviral Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diagnostic Errors; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Organophosphonates; Osteomalacia; Vitamin D Deficiency | 2019 |
Performance of serum HBcrAg in chronic hepatitis B patients with 8-year nucleos(t)ide analogs therapy.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Retrospective Studies; Seroconversion | 2019 |
Telbivudine and adefovir dipivoxil combination therapy improves renal function in patients with chronic hepatitis B: A STROBE-compliant article.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Young Adult | 2018 |
The clinical and pathological features of adefovir dipivoxil-related renal impairment
.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Female; Glycosuria; Hematuria; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Tubules, Proximal; Male; Middle Aged; Mitochondria; Organophosphonates; Phosphorus; Proteinuria; Renal Insufficiency; Uric Acid | 2019 |
The different effects of adefovir dipivoxil and telbivudine on the prognosis of hepatitis b virus-related hepatocellular carcinoma patients after curative resection.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Function Tests; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Nucleosides; Nucleotides; Organophosphonates; Prognosis; Retrospective Studies; Telbivudine | 2019 |
Adefovir dipivoxil sensitizes colon cancer cells to vemurafenib by disrupting the KCTD12-CDK1 interaction.
Topics: Adenine; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Colonic Neoplasms; Humans; Organophosphonates; Protein Binding; Proteins; Reverse Transcriptase Inhibitors; Vemurafenib | 2019 |
[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B].
Topics: Adenine; Aged; Carcinoma, Hepatocellular; Fanconi Syndrome; Fractures, Bone; Hepatitis B, Chronic; Humans; Hypophosphatemia; Liver Neoplasms; Male; Organophosphonates; Osteomalacia; Time Factors | 2019 |
Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report.
Topics: Adenine; Adult; Antiviral Agents; Bone Density Conservation Agents; Denosumab; Fanconi Syndrome; Hepatitis B; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Tomography, Emission-Computed; Treatment Outcome | 2019 |
Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage.
Topics: Adenine; Antiviral Agents; BRCA1 Protein; Cell Line; Chromosome Aberrations; DNA Damage; Gene Deletion; Hepatitis B, Chronic; Humans; Organophosphonates | 2019 |
Long-term prognosis of liver disease in patients with chronic hepatitis B virus infection receiving nucleos(t)ide analogue therapy: an analysis using a Markov chain model.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Markov Chains; Middle Aged; Nucleosides; Organophosphonates; Prognosis | 2019 |
Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible?
Topics: Adenine; Aged; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Diseases; Male; Middle Aged; Organophosphonates; Osteomalacia | 2019 |
Identification of novel adefovir dipivoxil-saccharin cocrystal polymorphs and their thermodynamic polymorphic transformations.
Topics: Adenine; Crystallization; Organophosphonates; Saccharin; Thermodynamics | 2019 |
Voltammetric determination of adefovir dipivoxil by using a nanocomposite prepared from molecularly imprinted poly(o-phenylenediamine), multi-walled carbon nanotubes and carbon nitride.
Topics: Adenine; Electrochemical Techniques; Electrodes; Humans; Limit of Detection; Molecular Imprinting; Nanocomposites; Nanotubes, Carbon; Nitriles; Organophosphonates; Phenylenediamines; Reproducibility of Results | 2019 |
In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue.
Topics: Activating Transcription Factor 4; Adenine; Antiviral Agents; Apoptosis; Caspase 12; Cell Line; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Epithelial Cells; Female; Glomerular Filtration Rate; Heat-Shock Proteins; Hepatitis A Virus Cellular Receptor 1; Hepatitis B, Chronic; Humans; In Vitro Techniques; Interleukin-18; Kidney Tubules; Lamivudine; Lipocalin-2; Male; Middle Aged; Organophosphonates; Prospective Studies; Protective Agents; Renal Insufficiency, Chronic; Severity of Illness Index; Telbivudine; Tenofovir | 2019 |
Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunomodulation; Interferon-alpha; Interleukin-10; Interleukin-12; Lamivudine; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Nucleosides; Organophosphonates; Proto-Oncogene Proteins c-akt; Tenofovir | 2020 |
[Analysis of resistance mutations in patients with persistent low viral load during antiviral therapy with tebivudine alone or in combination with adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Telbivudine; Viral Load | 2019 |
Pregnancy outcomes for pregnant women with chronic hepatitis B exposing to entecavir or adefovir dipivoxil therapy before or in early pregnancy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Pregnancy Outcome; Pregnant Women; Retrospective Studies; Treatment Outcome; Viral Load | 2022 |
Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor-related cytotoxicity.
Topics: Adenine; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; DNA Replication; Humans; Organophosphonates; Protein Kinase Inhibitors; Signal Transduction | 2020 |
Hypophosphatemic Osteomalacia Due to Adefovir-Induced Fanconi Syndrome.
Topics: Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Female; Hepatitis C, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia; Tenofovir | 2020 |
Retrospective analysis of the clinical characteristics of adefovir dipivoxil-induced Fanconi's syndrome in the Chinese population.
Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Asian People; Bone Density; Fanconi Syndrome; Female; Glycosuria; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteoporosis; Retrospective Studies; Young Adult | 2020 |
Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia; Renal Insufficiency | 2020 |
Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator.
Topics: Adenine; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Drug Stability; Injections, Intravenous; Iodine Radioisotopes; Lipids; Liver; Liver Function Tests; Mice; Nanoparticles; Organophosphonates; Particle Size; Rose Bengal; Thioacetamide | 2020 |
Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Drug Discovery; Herpesvirus 1, Suid; High-Throughput Screening Assays; Mice; Mice, Inbred BALB C; Organophosphonates; Pseudorabies; Small Molecule Libraries; Swine; Virus Replication | 2021 |
Severe hypophosphataemic osteomalacia related to low-dose adefovir dipivoxil therapy in a hepatitis B virus patient.
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia | 2021 |
Effect of Coformer Selection on In Vitro and In Vivo Performance of Adefovir Dipivoxil Cocrystals.
Topics: Acetaminophen; Adenine; Animals; Area Under Curve; Caco-2 Cells; Cell Membrane Permeability; Chemistry, Pharmaceutical; Crystallization; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Models, Biological; Molecular Conformation; Niacinamide; Organophosphonates; Rats; Saccharin; Solubility; Water | 2021 |