adenine has been researched along with 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.13) | 18.7374 |
| 1990's | 22 (56.41) | 18.2507 |
| 2000's | 9 (23.08) | 29.6817 |
| 2010's | 6 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Naesens, L | 1 |
| De Clercq, E | 1 |
| De Clercq, E; Konno, K; Mochizuki, S; Mori, S; Shigeta, S; Yokota, T | 1 |
| Balzarini, J; De Clercq, E; Holý, A; Naesens, L; Rosenberg, I | 1 |
| De Clercq, E; Holý, A; Rosenberg, I | 1 |
| Balestra, E; Balzarini, J; Caliò, R; De Clercq, E; Del Gobbo, V; Holy, A; Perno, CF; Sesa, F; Villani, N | 1 |
| De Clercq, E; Kaminsky, R; Zweygarth, E | 1 |
| De Clercq, E; Neyts, J | 1 |
| Holý, A; Merta, A; Stĕtina, R; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Holy, A; Naesens, L; Neyts, J; Rosenberg, I | 1 |
| Bruggeman, C; De Clercq, E; Neyts, J; Stals, F | 1 |
| Balzarini, J; De Clercq, E; Dvoráková, H; Holý, A; Naesens, L; Reymen, D | 1 |
| Konno, K; Shigeta, S; Sudo, K; Yokota, T | 1 |
| Andrei, G; De Clercq, E; Snoeck, R | 1 |
| Blazek, K; Holý, A; Kohoutová, M; Otová, B; Panczak, A; Schramlová, J; Sladká, M | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 1 |
| Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I | 1 |
| Havel, J; Holý, A; Revilla, A; Vargas, G | 1 |
| Eckschlager, T; Franek, F; Holy, A; Votruba, I | 1 |
| Compton, ML; Paborsky, LR; Toole, JJ | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L; Segers, C; Verbeken, E; Waer, M | 1 |
| Downey, KM; Kramata, P | 1 |
| Holy, A; Mandys, V; Mráz, M; Otová, B; Panczak, A; Schramlová, J; Votruba, I | 1 |
| Holý, A; Horská, K; Krejcová, R; Votruba, I | 1 |
| De Clercq, E; Frison, E; Helliot, B; Lepoivre, P; Neyts, J; Panis, B; Swennen, R | 1 |
| Canová, NK; Farghali, H; Holý, A; Kmonícková, E; Zídek, Z | 1 |
| Andrei, G; De Clercq, E; Holý, A; Horejsí, K; Pohl, R; Snoeck, R | 1 |
| Croubels, S; De Backer, P; Garré, B; Nauwynck, H; Neyts, J; Nugent, J; van der Meulen, K | 1 |
| Hanzalová, J; Holý, A; Otová, B; Starková, J; Votruba, I; Zápotocký, M | 1 |
| Andrei, G; De Clercq, E; Fiten, P; Froeyen, M; Opdenakker, G; Snoeck, R | 1 |
| Holý, A; Otová, B; Votruba, I | 1 |
| Holy, A; Hrdy, J; Otová, B; Votruba, I | 1 |
| Balzarini, J; Herman, BD; Holy, A; Sluis-Cremer, N; Votruba, I | 1 |
| Cvilink, V; Hájek, M; Holý, A; Mertlíková-Kaiserová, H; Votruba, I | 1 |
| Holý, A; Mertlíková-Kaiserová, H; Procházková, E; Rumlová, M; Tloušťová, E; Votruba, I | 1 |
| Holy, A; Mertlíková-Kaiserová, H; Nejedlá, M; Votruba, I | 1 |
| Blindauer, CA; Gómez-Coca, RB; Holý, A; Operschall, BP; Sigel, A; Sigel, H | 1 |
| Andrei, G; Cannizzaro, C; Cihlar, T; Fiten, P; Frey, CR; Fung, W; Geleziunas, R; Han, B; Hung, M; Liu, X; Opdenakker, G; Snoeck, R; Votruba, I | 1 |
2 review(s) available for adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
| Article | Year |
|---|---|
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Retroviridae Infections; Virus Diseases | 1990 |
[Acyclic nucleoside phosphonates as potential antineoplastic agents].
Topics: Adenine; Alanine; Animals; Antineoplastic Agents; Cell Line, Tumor; Guanine; Humans; Lymphoma, Non-Hodgkin; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines | 2008 |
37 other study(ies) available for adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine
| Article | Year |
|---|---|
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin | 1990 |
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Cell Transformation, Viral; Drug Administration Schedule; Injections, Intraperitoneal; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental | 1991 |
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis.
Topics: Adenine; Antiviral Agents; DNA Replication; DNA, Viral; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1990 |
9-(2-Phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP): a novel agent with anti-human immunodeficiency virus activity in vitro and potent anti-Moloney murine sarcoma virus activity in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Drug Evaluation, Preclinical; Embryo, Mammalian; HIV; Humans; Mice; Moloney murine sarcoma virus; Sarcoma Viruses, Murine; T-Lymphocytes; Virus Replication | 1989 |
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.
Topics: Adenine; Animals; Antiviral Agents; Brain Diseases; Herpes Simplex; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Hairless; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Vaccinia | 1989 |
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.
Topics: Adenine; Animals; Antiviral Agents; Interferons; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Time Factors | 1994 |
Antitrypanosomal activity of phosphonylmethoxyalkylpurines.
Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African | 1994 |
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; DNA, Viral; Ganciclovir; Herpesviridae Infections; Humans; Immunologic Deficiency Syndromes; Mice; Mice, SCID; Muromegalovirus; Organophosphonates; Organophosphorus Compounds; Virus Replication | 1994 |
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine | 1993 |
Efficacy of oral 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the treatment of retrovirus and cytomegalovirus infections in mice.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cytomegalovirus Infections; Friend murine leukemia virus; Injections, Intraperitoneal; Leukemia, Experimental; Mice; Moloney murine sarcoma virus; Sarcoma, Experimental; Survival Rate; Treatment Outcome | 1993 |
Activity of the anti-HIV agent 9-(2-phosphonyl-methoxyethyl)-2,6-diaminopurine against cytomegalovirus in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; DNA Replication; DNA, Viral; Fibroblasts; Humans; Immunocompromised Host; Mice; Mice, SCID; Rats | 1993 |
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytopathogenic Effect, Viral; Cytosine; Flow Cytometry; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds | 1995 |
Colorimetric assay system for screening antiviral compounds against hepatitis B virus.
Topics: Adenine; Antiviral Agents; Base Sequence; Colorimetry; DNA Primers; DNA, Viral; Drug Evaluation, Preclinical; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Molecular Sequence Data; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1996 |
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Drug Resistance, Microbial; Fibroblasts; Foscarnet; Humans; Lung; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid | 1996 |
Inhibition of acute graft-versus-host disease in (LEW.1W x LEW.1A)F1 rats using 9-(2-phosphonomethoxyethyl)-2,6-diaminopurine.
Topics: Adenine; Animals; Graft vs Host Disease; Histocompatibility Antigens; Immunosuppressive Agents; Inbreeding; Lymph Nodes; Lymphocyte Transfusion; Rats; Rats, Inbred Lew; Time Factors; Transplantation, Homologous | 1997 |
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Genotoxicity of purine acyclic nucleotide analogs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine | 1997 |
Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides.
Topics: Adenine; Anti-HIV Agents; Electrophoresis, Capillary; Organophosphonates; Ribonucleotides | 1998 |
Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Deamination; Dideoxynucleosides; Guanine; Humans; Organophosphorus Compounds; Prodrugs; Rats; Tumor Cells, Cultured | 1999 |
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antineoplastic Agents; Choriocarcinoma; Female; Guanine; Male; Organophosphonates; Organophosphorus Compounds; Pregnancy; Prodrugs; Rats; Tumor Cells, Cultured; Uterine Neoplasms | 1999 |
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
Therapeutic effect of heat shock on T-cell lymphoma in inbred Sprague-Dawley rat.
Topics: Adenine; Animals; Antimetabolites, Antineoplastic; Apoptosis; Body Weight; Combined Modality Therapy; Cryotherapy; Female; Heat-Shock Proteins; HSP72 Heat-Shock Proteins; Hyperthermia, Induced; Immersion; Lymphoma, T-Cell; Male; Neoplasm Proteins; Neoplasm Transplantation; Neoplastic Syndromes, Hereditary; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Stress, Physiological; Tumor Suppressor Protein p53 | 1999 |
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Topics: Adenine; Animals; Antineoplastic Agents; Guanine; Guanosine Monophosphate; Guanylate Kinases; Isoenzymes; Kinetics; Nucleoside-Phosphate Kinase; Organophosphorus Compounds; Phosphorylation; Substrate Specificity; Swine | 2000 |
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
Topics: Adenine; Antiviral Agents; Badnavirus; Musa; Organophosphonates; Organophosphorus Compounds; Plant Diseases; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2003 |
Modulator of intracellular Ca(2+), thapsigargin, interferes with in vitro secretion of cytokines and nitric oxide.
Topics: Adenine; Animals; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Cytokines; Endoplasmic Reticulum; Enzyme Inhibitors; Female; Glutathione; Immunosuppressive Agents; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Thapsigargin; Tumor Necrosis Factor-alpha | 2005 |
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
Topics: Adenine; Antiviral Agents; Cell Proliferation; Cytomegalovirus; Guanine; Herpesvirus 3, Human; Humans; Organophosphorus Compounds; Structure-Activity Relationship | 2006 |
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Epithelial Cells; Foscarnet; Ganciclovir; Herpesvirus 1, Equid; Horses; Lung; Organophosphonates | 2007 |
Experimental therapy with 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP): origin of resistance.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lymphoma; Male; Multidrug Resistance-Associated Proteins; Neoplasm Transplantation; Organ Size; Rats; Rats, Sprague-Dawley; Transcriptional Activation | 2007 |
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Disease Models, Animal; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Exodeoxyribonucleases; Foscarnet; Genotype; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Models, Molecular; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Phenotype; Protein Binding; Protein Conformation; Vero Cells; Viral Proteins; Virulence | 2007 |
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
Topics: Adenine; Animals; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Guanine; Lymphoma, T-Cell; Male; Neovascularization, Pathologic; Organophosphorus Compounds; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2009 |
The acyclic 2,4-diaminopyrimidine nucleoside phosphonate acts as a purine mimetic in HIV-1 reverse transcriptase DNA polymerization.
Topics: Adenine; Base Sequence; Catalytic Domain; DNA Primers; DNA Replication; HIV Reverse Transcriptase; HIV-1; Hydrocarbons, Acyclic; Kinetics; Models, Molecular; Molecular Mimicry; Molecular Structure; Mutagenesis, Site-Directed; Pyrimidine Nucleosides; Pyrimidines; Recombinant Proteins | 2010 |
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
Topics: Adenine; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; In Situ Hybridization, Fluorescence; Organophosphorus Compounds; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA; Telomerase; Telomere; Time Factors | 2010 |
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Topics: Adenine; Adenylate Kinase; Amino Acid Sequence; Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Guanine; Guanylate Kinases; Humans; Molecular Sequence Data; Organophosphorus Compounds; Phosphorylation; Point Mutation | 2011 |
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
Topics: Adenine; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Guanine; HL-60 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Organophosphorus Compounds; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2012 |
Extent of intramolecular π-stacks in aqueous solution in mixed-ligand copper(II) complexes formed by heteroaromatic amines and several 2-aminopurine derivatives of the antivirally active nucleotide analog 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Topics: 2-Aminopurine; Adenine; Amines; Antiviral Agents; Coordination Complexes; Copper; Drug Stability; Molecular Structure; Solutions; Water | 2012 |
Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.
Topics: Adenine; Alanine; Amino Acid Sequence; Antineoplastic Agents; Blotting, Western; Drug Resistance, Neoplasm; Female; Humans; Molecular Sequence Data; Mutation; Nucleoside Deaminases; Prodrugs; Protein Conformation; Purines; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2013 |