adenine has been researched along with 9-(2-hydroxy-3-nonyl)adenine in 416 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 156 (37.50) | 18.7374 |
| 1990's | 133 (31.97) | 18.2507 |
| 2000's | 86 (20.67) | 29.6817 |
| 2010's | 38 (9.13) | 24.3611 |
| 2020's | 3 (0.72) | 2.80 |
| Authors | Studies |
|---|---|
| Edwards, NL; Fox, IH; Mitchell, BS; Wortmann, RL | 1 |
| Diamond, HS; Meisel, AD; Natarajan, C; Sterba, G | 1 |
| Lukey, T; Snyder, FF | 1 |
| Kelley, WN; Mitchell, BS; Wilson, JM | 1 |
| Deeprose, RD; Duncan, GS; Harvey, RJ; Wolberg, G; Zimmerman, TP | 1 |
| Chiba, P; Kraupp, M; Müller, MM | 1 |
| Cohen, SS; Plunkett, W | 1 |
| Altiok, N; Balmforth, AJ; Fredholm, BB | 1 |
| Abushanab, E; Harriman, GC; Midgett, RM; Poirot, AF; Stoeckler, JD | 1 |
| Berne, RM; Coleman, SD; Ely, SW; Matherne, GP | 1 |
| Cristalli, G; Falasca, M; Grifantini, M; Lupidi, G; Marmocchi, F; Riva, F; Venardi, G; Whitehead, E | 1 |
| Belt, JA; Cass, CE; Dagnino, L; Gati, WP; Paterson, AR; Vijayalakshmi, D | 1 |
| Abushanab, E; Porter, DJ | 1 |
| O'Regan, MH; Perkins, LM; Phillis, JW | 1 |
| Geiger, JD; Gu, JG | 1 |
| Gingell, RL; Lasley, RD; Mentzer, RM; Schmit, TJ; Van Wylen, DG | 1 |
| Ayers, CR; Feldman, MD; Iflah, S; Linden, J; Patel, A; Ripley, ML; Taylor, HE; Woodward, EB | 1 |
| Campbell, G; Edwards, JG; Grierson, AW; Kinn, SR | 1 |
| Cunha, RA; Sebastião, AM | 1 |
| Averett, DR; Biron, KK; Burnette, TC; de Miranda, P; Krenitsky, TA; Miller, RL | 1 |
| Delaney, SM; Geiger, JD; Nagy, JI; Padua, RA | 1 |
| Marlewski, M; Rutkowski, B; Smolenski, RT; Swierczynski, J; Zydowo, MM | 1 |
| Capuozzo, E; Crifò, C; Salerno, C; Siems, W | 1 |
| Lieberman, M; Wagenknecht, B | 1 |
| Chen, S; Chen, X; Hao, J; Ju, H; Lai, Z; Zhang, H; Zhang, W; Zhao, S; Zhu, Q; Zou, C | 1 |
| Burrier, AC; Jeng, AY; Oei, HH | 1 |
| Dorheim, TA; Hoffman, A; Mentzer, RM; Van Wylen, DG | 1 |
| Carney, DF; Papadimitriou, JC; Shin, ML | 1 |
| Van Belle, H | 2 |
| Cristalli, G; Eleuteri, A; Franchetti, P; Grifantini, M; Lupidi, G; Vittori, S | 1 |
| Howell, ML; Mathews, CK; Slabaugh, MB; Wang, Y | 1 |
| Fraher, LJ; McFadden, RG | 1 |
| Marlewski, M; Smoleński, RT | 1 |
| Carabaza, A; Ciudad, CJ; Guinovart, JJ; Mor, A; Ricart, MD | 1 |
| Caiolfa, VR; Gill, D; Parola, AH | 2 |
| Cory, JG; Matsumoto, M; Tihan, T | 1 |
| Belardinelli, L; Froldi, G | 1 |
| Zhu, Q | 1 |
| Abd-Elfattah, AS; Hanan, SA; Jessen, ME; Tuchy, G; Wechsler, AS | 1 |
| Corvese, D; Weitberg, AB | 1 |
| Belardinelli, L; Boykin, MT; Hill, JA; Shryock, JC | 1 |
| Cory, JG; Matsumoto, M; Weckbecker, G | 1 |
| Katsuramaki, T; Muraoka, T; Shiraishi, H; Yokoyama, MM | 1 |
| de Jong, JW; Opie, LH; Owen, P; van der Meer, P; van Loon, H | 1 |
| Chen, SG; Zhu, QY; Zou, CM | 1 |
| Jackson, EK; Kuan, CJ; Wells, JN | 1 |
| Dhillon, GS; Honnor, RC; Londos, C | 1 |
| Cohen, SS | 1 |
| Church, MK; Hughes, PJ; Vardey, CJ | 1 |
| Butcher, RW; Clark, RB; Proll, MA | 1 |
| Kristensson, K; Lycke, E; Röyttä, M; Svennerholm, B; Vahlne, A | 1 |
| Dalaker, K; Prydz, H | 1 |
| Belloni, FL; Gerritsen, ME; Liang, BC | 1 |
| Roemer, EJ; Zieve, GW | 1 |
| Arora, PK; Inoue, M; Sei, Y; Tsuboi, I; Yokoyama, MM | 1 |
| Cespuglio, R; Gharib, A; Reynaud, D; Sarda, N | 1 |
| Penningroth, SM; Rose, PM; Rothacker, DQ | 1 |
| Bingham, H; Chan, VL; Du, RP; Juranka, P; Pang, JC | 1 |
| Deussen, A; Möser, GH; Schrader, J | 1 |
| Ammann, AJ; Cowan, MJ; Smith, W | 1 |
| Bürrig, KF; Kelm, MK; Kroll, K; Schrader, J | 1 |
| Bittar, N; Fu, LM; Koke, JR; Sun, D; Vaughan, DM | 1 |
| Deussen, A; Lloyd, HG; Schrader, J | 1 |
| Monteiro, EC; Ribeiro, JA | 1 |
| Bar, I; Caiolfa, VR; Parola, AH; Rosenwaks, S | 1 |
| DeMeester, CA; Pike, MC | 1 |
| Meghji, P; Middleton, KM; Newby, AC | 1 |
| Jacobs, AE; Oosterhof, A; Veerkamp, JH | 1 |
| Carter, GL; Cory, JG | 1 |
| Penningroth, SM | 1 |
| Henson, PM; Riches, DW; Stanworth, DR; Watkins, JL | 1 |
| Bonnafous, JC; Clofent, G; Dornand, J; Favero, J; Mani, JC | 1 |
| Fredholm, BB; Jonzon, B; Nilsson, J | 1 |
| Dorflinger, LJ; Schonbrunn, A | 1 |
| Feigl, EO; Kroll, K | 1 |
| Aultman, M; Gerrard, TL; Kaplan, AM; Squire, C; Strawson, J | 1 |
| Gudenzi, M; Mustafa, SJ; Nakagawa, Y | 1 |
| Cartner, LA; Holliss, DG; Humphrey, SM | 1 |
| Carabaza, A; Ciudad, CJ; Guinovart, JJ | 1 |
| Abd-Elfattah, AS; Brunsting, LA; Doherty, NE; Jessen, ME; Lekven, J; Wechsler, AS | 1 |
| Frederiksen, S; Overgaard-Hansen, K; Svendsen, KR | 1 |
| Feeney, RJ; Roemer, EJ; Zieve, GW | 1 |
| Dhalla, NS; Ganguly, PK; Gupta, MP; Panagia, V | 1 |
| Bordoni, T; Cristalli, G; Franchetti, P; Geroni, C; Grifantini, M; Lupidi, G; Riva, F; Verini, MA; Vittori, S | 1 |
| Mohrman, DE | 1 |
| Abarzua, M; Davis, JA; Lawton, A; Weinberg, JM | 1 |
| Adams, R; Drachman, DB; Kuncl, RW | 1 |
| Campochiaro, PA; Hackett, SF | 1 |
| Jennings, SR; Lum, CT; Tevethia, SS; Wanner, FJ | 1 |
| Coleman, MS; Danton, MJ | 1 |
| Kontinen, VP; Pispa, JP | 1 |
| Gerber, G; Rapoport, I; Rapoport, SM | 1 |
| Menzel, D; Schliwa, M | 1 |
| Brown, P; Gewirtz, H; Most, AS | 1 |
| DeWitt, DF; Heller, LJ; Sparks, HV | 1 |
| Tellam, RL; Walsh, TP | 1 |
| Koonce, MP; Schliwa, M | 1 |
| Silverstein, SC; Sung, SJ | 1 |
| Rutledge, CO; Samet, MK | 2 |
| DeLong, RE; Phillis, JW; Towner, JK | 1 |
| Samet, MK | 1 |
| Dóra, E | 1 |
| Wolberg, G; Zimmerman, TP | 1 |
| Castaneda, M; Codd, JE; Garvin, PJ; Jellinek, M; Niehoff, M | 1 |
| Archer, S; Chan, VL; Ho, JH; Juranka, PF | 1 |
| Hsiao, N; Lum, CT; Najarian, JS; Sutherland, DE | 1 |
| Plunkett, W | 1 |
| Elford, HL; Lin, AL | 2 |
| Cristalli, G; Grifantini, M; Lupidi, G; Marmocchi, F; Riva, F | 1 |
| Goday, A; Morris, GS; Simmonds, HA; Webster, DR | 1 |
| Seegmiller, JE | 1 |
| Achterberg, PW; de Jong, JW | 1 |
| Hirayama, T; Kato, I; Matsuda, F; Noda, M | 1 |
| Achterberg, PW; de Jong, JW; Harmsen, E | 1 |
| Corcoran, T; Huffaker, T; Wagner, JA | 1 |
| Lappin, D; Whaley, K | 1 |
| Cronstein, BN; Hirschhorn, R; Kramer, SB; Weissmann, G | 2 |
| Coffey, RG; Hadden, JW; Hartley, L; Krzanowski, JJ; Polson, JB | 1 |
| Burnstock, G; Meldrum, LA; Sneddon, P | 1 |
| Chiang, PK; Morita, Y; Siraganian, RP | 1 |
| Morita, Y; Siraganian, RP | 1 |
| Balboni, PG; Barbanti-Brodano, G; Busi, C; Fiume, L; Mattioli, A | 1 |
| Oosterhof, A; Peters, GJ; Veerkamp, JH | 1 |
| Ahl, R | 1 |
| Fahey, D; Fox, RM; Kefford, RF; McCairns, E; Muscat, GE; Rowe, PB | 1 |
| Brown, KJ; Forman, DS; Promersberger, ME | 1 |
| Benyon, RC; Church, MK; Holgate, ST | 1 |
| Ekström, P; Kanje, M | 1 |
| Bardin, CW; Gagnon, C | 1 |
| Clark, TG; Rosenbaum, JL | 1 |
| Tamm, SL; Yamin, MA | 1 |
| Stearns, ME | 1 |
| Blum, JJ; Hayes, A | 1 |
| Green, RD | 2 |
| Arnett, G; Cohen, SS; North, TW; Schabel, FM; Shannon, WM | 1 |
| Davis, JI; Fishbein, WN; Strong, DM; Winkert, JW | 1 |
| Deeprose, RD; Duncan, GS; Schmitges, CJ; Wolberg, G; Zimmerman, TP | 1 |
| Debons, AF; Libbin, RM; Norstrand, IF; Slade, WR | 1 |
| Cohen, T; Manor, D; Margalith, M | 1 |
| Abushanab, E; North, TW; O'Connor, L; Panzica, RP | 1 |
| North, TW | 1 |
| Aksamit, RR; Backlund, PS | 1 |
| Lum, CT; Robertson, CA; Tilberg, AF; Wanner, FJ | 1 |
| Euteneuer, U; Ezzell, RM; Schliwa, M | 1 |
| Bacon, PE; Carter, GL; Cory, JG; Sato, A | 2 |
| Goehl, K; Kuruvilla, A; Mendelson, WB; Paul, SM; Skolnick, P; Watlington, T | 1 |
| Balis, ME; Dunzendorfer, U; Fogh, J; Releyea, N; Whitmore, WF | 1 |
| Fairbanks, LD; Goday, A; Morris, GS; Simmonds, HA | 1 |
| Pasque, MK; Wechsler, AS | 1 |
| Myles, DG; Primakoff, P | 1 |
| Bardin, CW; Bouchard, P; Cheung, A; Gagnon, C; Penningroth, SM | 2 |
| Cande, WZ | 1 |
| Beckerle, MC; Porter, KR | 1 |
| Belardinelli, L; Berne, RM; Clemo, HF; DiMarco, JP; Shryock, J; West, GA | 1 |
| Fox, RM; Kefford, RF | 1 |
| Sandberg, G | 1 |
| Collet, H; De Bruyn, CH; Delespesse, G; van Laarhoven, JP | 1 |
| Fredholm, BB; Sollevi, A | 3 |
| Betz, M; Hänsch, GM; Shin, ML | 1 |
| Kille, JM; Klabunde, RE | 1 |
| Antonini, I; Cristalli, G; Franchetti, P; Grifantini, M; Lupidi, G; Martelli, S; Riva, F | 1 |
| Pike, MC; Snyderman, R | 1 |
| Pinkhas, J; Sidi, Y; Sperling, O; Trainin, N; Umiel, T | 1 |
| Feinberg, H; Kohler, J; Levitsky, S; Silverman, NA | 1 |
| Eloranta, TO; Raina, AM; Tuomi, K | 1 |
| Hermes, HH; Nabakowski, G; Osswald, H | 1 |
| Daddona, PE; Kelley, WN | 1 |
| Dosch, HM; Gelfand, EW; Shore, A | 1 |
| Coleman, MS; Deibel, MR; Hutton, JJ | 1 |
| Aye, MT; Dunne, JV | 1 |
| Ballow, M; Pantschenko, AG | 1 |
| Hirschhorn, R; Ratech, H | 1 |
| Hirschhorn, R; Kuritsky, L; Ratech, H; Thorbecke, GJ | 1 |
| Fox, IH; Palella, TD; Schatz, RA; Wilens, TE | 1 |
| Kajander, EO | 1 |
| Fredholm, BB; Lerner, U | 1 |
| Lambe, CU; Nelson, DJ | 1 |
| Abushanab, E; Bastian, G; Berman, SF; Bessodes, M; Chen, SF; Marcaccio, EJ; Panzica, RP; Parks, RE; Stoeckler, JD | 1 |
| Humphrey, SM; Seelye, RN | 1 |
| Gavin, JB; Humphrey, SM; Seelye, RN | 1 |
| Eloranta, TO; Kajander, EO; Raina, AM | 1 |
| Abushanab, E; Berman, SF; Burgess, FW; Chen, SF; Choi, HS; Marcaccio, EJ; Panzica, RP; Parks, RE; Steen, PA; Stoeckler, JD | 1 |
| Kredich, NM; Pike, MC; Snyderman, R | 1 |
| Baker, DC; Hanvey, JC; Hawkins, LD; Murphy, J | 1 |
| Abushanab, E; Bastian, G; Bessodes, M; Chen, SF; Panzica, RP; Parks, RE; Stoeckler, JD | 1 |
| Spector, T | 1 |
| Einzig, S; Foker, JE; Wang, T | 1 |
| Shimizu, T | 1 |
| Corsi, C; Fratti, S; Pazzagli, M; Pedata, F; Pepeu, G | 1 |
| Fischmeister, R; Méry, PF; Pavoine, C; Pecker, F | 1 |
| Kulkarni, JS; Palmer, KC; Przywara, DA; Wakade, AR; Wakade, TD | 1 |
| Fredholm, BB; Lloyd, HG | 1 |
| Abd-Elfattah, AS; Ding, M; Wechsler, AS | 1 |
| Gallagher, KP; Ignasiak, DP; Martin, BJ; McClanahan, TB; Mertz, TE; Saganek, LJ; Van Wylen, DG; Vinten-Johansen, J | 1 |
| Hiramoto, Y; Ishijima, S | 1 |
| Krnjević, K; Zhu, PJ | 1 |
| Abushanab, E; Li, SY; Pragnacharyulu, PV; Sarma, MS; Stoeckler, JD; Vargeese, C | 1 |
| Abd-Elfattah, AS; Jessen, ME; Wechsler, AS | 1 |
| Abd-Elfattah, AS; Wechsler, AS | 1 |
| Lautt, WW; Zhang, YL | 1 |
| Doyle, MP; Duling, BR; Linden, J | 1 |
| Abd-Elfattah, AS; Bolli, R; Jeroudi, MO; Sekili, S; Sun, JZ; Tang, XL; Zughaib, ME | 1 |
| Abd-Elfattah, AS; Ding, M; Dyke, CM; Wechsler, AS | 1 |
| Burrier, AC; Janero, DR; Sandhu, GS | 1 |
| Claydon, MA; Hicks, GL; Wang, T; Yang, X; Zhu, Q | 1 |
| Kessel, D; Zemlicka, J | 1 |
| Dunwiddie, TV; Lupica, CR; Mitchell, JB | 1 |
| Sciotti, VM; Van Wylen, DG | 1 |
| Meno, JR; Ngai, AC; Winn, HR | 1 |
| Lasley, RD; Mentzer, RM | 1 |
| Pazzagli, M; Pedata, F; Pepeu, G | 1 |
| Geiger, JD; Gu, JG; Kala, G | 1 |
| Abd-Elfattah, AS; Aly, HM; Crescenzo, DG; Domkowski, PW; Hopkins, RA; Jones, JL; Messier, RH; Wallace, RB | 1 |
| Müller, A; Nennstiel, P; Podzuweit, T | 1 |
| Cristalli, G; Franchetti, P; Grifantini, M; La Colla, P; Marongiu, ME; Pani, A; Tinti, E | 1 |
| Dubey, RK; Gillespie, DG; Jackson, EK; Mi, Z; Suzuki, F | 1 |
| Khatchikian, G; Xia, Y; Zweier, JL | 1 |
| Haynes, J; Killilea, DW; Peterson, PD; Thompson, WJ | 1 |
| Bengtsson, T; Grenegård, M; Stendahl, O; Zalavary, S | 1 |
| Barber, B; Marples, D; Taylor, A | 1 |
| Hernandez, ML; Martinez, MJ; Ochoa, B | 1 |
| Harnett, MM; Houslay, MD; Lobban, M; Michie, AM; Müller, T | 1 |
| Geiger, JD; Gu, JG; Nath, A | 1 |
| Correia-de-Sá, P; Ribeiro, JA | 1 |
| Delhumeau, G; Trejo, R; Valadéz-Salazar, A | 1 |
| Downey, HF; Lee, SC; Mallet, RT | 1 |
| Chen, W; Guéron, M | 1 |
| Larsen, AK; Osborne, NN | 1 |
| Alekseev, AE; Gomez, LA; Parkinson, SJ; Terzic, A; Wagner, F; Waldman, SA | 1 |
| Monteiro, EC; Monteiro, TC; Silva e Sousa, MA; Vera-Cruz, P | 1 |
| Dickinson, NT; Haslam, RJ; Jang, EK | 1 |
| Bénardeau, A; Fischmeister, R; Hatem, S; Mercadier, JJ; Rivet-Bastide, M; Vandecasteele, G; Verde, I | 1 |
| Huang, CR; Nikolic, D; van Breemen, RB; Venton, DL; Woodbury, CP; Zhao, YZ | 1 |
| Bourguignon, JJ; Désaubry, L; Lugnier, C; Raboisson, P; Wermuth, CG | 1 |
| Breadon, EL; Lindsay, KE; Prior, C | 1 |
| Ishikawa, S; Okada, Y; Saijoh, K | 1 |
| Barth, A; Janigro, D; Meno, JR; Newell, DW; Nguyen, LB; Wender, R; Winn, HR | 1 |
| Brause, M; Delabar, U; Eckardt, KU; Gleiter, CH; Zebski, H | 1 |
| Oliveira, CR; Rego, AC; Santos, MS | 1 |
| Dubey, RK; Gillespie, DG; Jackson, EK; Mi, Z | 2 |
| Abushanab, E; Barankiewicz, J; Danks, AM; Fox, A; Makings, L; Marangos, PJ; Pragnacharyulu, PV; Wallis, RA; Wiemann, T | 1 |
| Huang, CR; Nikolic, D; Schilling, A; van Breemen, RB; Venton, DL; Woodbury, CP; Zhao, YZ | 1 |
| Dubey, RK; Gillespie, DG; Jackson, EK | 2 |
| Kalsi, KK; Kochan, Z; Smolenski, RT; Yacoub, MH; Zych, M | 1 |
| Eisenbrand, G; Fürstenberger, G; Marko, D; Romanakis, K; Steinbauer, B; Zankl, H | 1 |
| Kobayashi, T; Okada, Y; Yamada, T | 1 |
| Manthei, SA; Reiling, CM; Van Wylen, DG | 1 |
| Abd-Elfattah, AS; Jessen, ME; Maddox, RP; Rebeyka, IM; Wechsler, AS | 1 |
| Abd-Elfattah, AS; Jessen, ME; Lekven, J; Wechsler, AS | 1 |
| Kalsi, KK; Smolenski, RT; Yacoub, MH | 2 |
| Anderson, BD; Ho, NF; Singhal, D | 1 |
| Anderson, BD; Singhal, D | 1 |
| Maurice, DH; Palmer, D; Tsoi, K | 1 |
| Job, RF; Minor, TR; Woodson, JC | 1 |
| Clauss, W; Rehn, M; Weber, WM | 1 |
| Kalsi, K; Kochan, Z; Smolenski, RT; Yacoub, MH; Zych, M | 1 |
| Barankiewicz, J; Danks, AM; Marangos, PJ | 1 |
| Jackson, EK; Kusaka, H; Li, P; Tofovic, SP | 1 |
| Hirohashi, N; Lennarz, WJ | 1 |
| Ashraf, M; Hirai, K | 1 |
| Fukamachi, M; Morita, T; Motoyashiki, T; Shiomi, H; Ueki, H | 1 |
| Li, KM; Lloyd, HG; Ludowyke, RI; Ross, L | 1 |
| Brundege, JM; Dunwiddie, TV | 1 |
| Cristalli, G; Lupidi, G; Marmocchi, F | 1 |
| IJzerman, AP; Pavan, B | 1 |
| Addicks, K; Andressen, C; Bloch, W; Feelisch, M; Fleischmann, BK; Hescheler, J; Ji, GJ | 1 |
| Amerini, S; Filippi, S; Ledda, F; Maggi, M; Natali, A | 1 |
| Richardt, G; Schreieck, J | 1 |
| Benelli, C; Clot, JP; Desbuquois, B; Fouque, F; Geoffroy, V; Lugnier, C; Nivet, V | 1 |
| Aoki, M; Narimatsu, E | 1 |
| Deussen, A; Kelm, M; Schäfer, S; Stappert, M | 1 |
| Flavin, MP; Ho, LT | 1 |
| Côté, M; Gallo-Payet, N; Guillon, G; Payet, MD; Rousseau, E | 1 |
| O'Regan, MH; Phillis, JW; Song, D | 1 |
| Dale, TJ; Dupere, JR; Starkey, SJ; Xie, X | 1 |
| Callaghan, F; Hourani, SM; Tennant, JP; Turner, C | 1 |
| Dubey, RK; Gillespie, DG; Jackson, EK; Shue, H | 1 |
| Headrick, JP; Hinschen, AK; Rose'Meyer, RB | 1 |
| Curry, FE; He, P; Zeng, M | 1 |
| Barry, CP; Lind, SE | 1 |
| Eng, KH; Min, HW; Moochhala, S | 1 |
| Schäfer, T; Schilling, MK; Sckell, A; Tian, YH | 1 |
| Aden, U; Berman, RF; Fredholm, BB; O'Connor, WT | 1 |
| Dhalla, AK; Dodam, JR; Johnson, LR; Jones, AW; Laughlin, MH; Magliola, L; Rubin, LJ | 1 |
| Abushanab, E; Chang, IF; Curtis, MA; Pragnacharyulu, PV; Varkhedkar, V | 1 |
| Keeling, IM; Obermayr, RP; Schneider, B; Spieckermann, PG | 1 |
| Abe, Y; Fujisawa, Y; Fukui, T; He, H; Kimura, S; Miura, K; Nishiyama, A; Rahman, M | 1 |
| Garvin, JL; Ortiz, PA | 1 |
| Antonyan, A; Armenyan, A; Cristalli, G; Lupidi, G; Mardanyan, S; Sharoyan, S | 1 |
| Alloatti, G; Bedendi, I; Biasin, C; Gallo, MP; Levi, RC; Malan, D | 1 |
| Lee, JJ; Parsons, ME; Talubmook, C | 1 |
| Dittrich, M; Fischmeister, R; Fleischmann, B; Georget, M; Hescheler, J; Jurevicius, J; Rochais, F | 1 |
| Carcillo, JA; Jackson, EK; Tofovic, SP; Zacharia, L | 1 |
| Cerniway, RJ; Headrick, JP; Matherne, GP; Peart, J | 1 |
| Abunasra, H; Jayakumar, J; Kalsi, KK; Raisky, O; Slominska, EM; Smolenski, RT; Suzuki, K; Yacoub, MH | 1 |
| Crum, AV; Meno, JR; Winn, HR | 1 |
| Anderson, BD; DeGraw, RT | 1 |
| Herring, N; Paterson, DJ; Rigg, L; Terrar, DA | 1 |
| Andrew, CM; Ciccarelli, R; Crocker, CE; Di Iorio, P; Kleywegt, S; Rathbone, MP; Traversa, U; Werstiuk, ES | 1 |
| Biagi, G; Costa, B; Giorgi, I; Giusti, L; Livi, O; Mazzoni, MR; Pacchini, F; Rum, P; Scartoni, V | 1 |
| Asaka, Y; Hara, A; Ito, Z; Kusakari, J; Tabuchi, K; Tsuji, S | 1 |
| Bell, EL; Doyle, DD; Palfrey, HC; Upshaw-Earley, J | 1 |
| Brading, AF; Jones, OM; McC Mortensen, NJ | 1 |
| Brenna, KJ; Colman, RW; Manns, JM; Sheth, SB | 1 |
| O'Donnell, JM; Suvarna, NU | 1 |
| Brackenborough, KT; Duffy, C; Hagan, RM; Jones, SA; Morgan, PF; Pratt, GD; Sargent, RS; Southam, E; Stratton, SC | 1 |
| Alfinito, PD; Alli, R; Townes-Anderson, E | 1 |
| Benton, HP; Kollias-Baker, C; MacDonald, MH; Tesch, AM | 1 |
| Eikyu, Y; Kinoshita, T; Kuno, M; Nakamura, K; Nakanishi, I; Nishio, N; Sakane, K; Sato, A; Seki, N; Terasaka, T | 1 |
| Deussen, A; Lauer, T; Loncar, R | 1 |
| Delbecque, JP; Gautron, F; Manière, G; Vanhems, E | 1 |
| Bernard, EA; de Souza, LF; Gelain, DP | 1 |
| Hentschel, S; Lewerenz, A; Nieber, K | 1 |
| Hernández, J; Juan-Fita, MJ; Vargas, ML | 2 |
| Boons, GJ; Hasko, G; Leibovich, SJ; Pinhal-Enfield, G; Ramanathan, M; Salzman, AL; Vogel, SN | 1 |
| Favot, L; Holl, V; Keravis, T; Le Bec, A; Lugnier, C | 1 |
| Knowles, AF; Wen, LT | 1 |
| Lundholt, BK; Pagliaro, L; Scudder, KM | 1 |
| Lobo, MG; Ribeiro, JA; Sebastião, AM | 1 |
| Andersson, TP; Sköld, HN; Svensson, SP | 1 |
| Ito, H; Kimura, Y; Sudo, T | 1 |
| Lazar, MJ; Punjabi, K; Scholz, PM; Tse, J; Weiss, HR | 1 |
| Bachteeva, VT; Chernigovskaya, EV; Fock, EM; Lavrova, EA; Parnova, RG | 1 |
| Gerth, A; Hauschildt, S; Kronstein, R; Nieber, K; Thiele, A; Wetzel, A | 1 |
| Cho, KW; Cui, X; Jin, JY; Kim, SH; Kim, SM; Kim, SZ; Lee, HS; Wen, JF | 1 |
| Iwaki-Egawa, S; Namiki, C; Watanabe, Y | 1 |
| Bernard, EA; De Souza, LF; Gelain, DP; Jardim, FR; Moreira, JC; Ribeiro, GR; Zim, M | 1 |
| Cseppento, A; Gesztelyi, R; Hajdú, P; Szabó, JZ; Szentmiklósi, AJ; Zsuga, J | 1 |
| Nagai, K; Nakagawa, K; Nishizaki, T; Saitoh, M; Yamamoto, S; Yamamura, T | 1 |
| Conlon, BA; Law, WR | 1 |
| Bischoff, E; Stasch, JP | 1 |
| Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N | 1 |
| Choi, JW; Ko, KH; Yoo, BK; Yoon, SY | 1 |
| Scholz, PM; Su, J; Weiss, HR | 1 |
| Handy, DE; Loscalzo, J; Zhang, Y | 1 |
| Cao, Q; Ding, YH; Ellenberger, T; Iffland, A; Kamath, AV; Kohls, D; Kothe, M; Low, S; Luan, J; Zhang, Y | 1 |
| Acevedo-Arozena, A; Berger, Z; Brown, SD; Imarisio, S; O'Kane, CJ; Ravikumar, B; Rubinsztein, DC; Vacher, C | 1 |
| Kaneda, T; Nakajyo, S; Shimizu, K; Urakawa, N; Watanabe, A | 1 |
| Cherubini, E; Giniatullin, R; Kasyanov, AM; Safiulina, VF | 1 |
| Davidov, T; Lazar, M; Molino, B; Rodriguez, R; Scholz, PM; Su, J; Tse, J; Weiss, HR; Zhang, Q | 1 |
| Ghavami, S; Hashemi, M; Karami-Tehrani, F; Los, M; Maddika, S | 1 |
| Abrams, K; Chambers, RJ; Garceau, NY; Kamath, AV; Lam, KT; Lilley, SC; Manley, CM; Otte, DA; Scott, DO; Sheils, AL; Tess, DA; Vellekoop, AS; Zhang, Y | 1 |
| Bernard, EA; de Souza, LF; Gelain, DP; Jardim, FR; Ribeiro, GR; Zim, M | 1 |
| Roberts, EL | 1 |
| Cheung, YF; Dostmann, WR; Houslay, MD; Kass, DA; Lissandron, V; Mongillo, M; Paolocci, N; Pozzan, T; Terrin, A; Tocchetti, CG; Zaccolo, M | 1 |
| Chambers, MG; Mason, RM; Mistry, D | 1 |
| Agarwal, A; Giles, GI; Hock, T; Johnson, KK; Kelley, EE; Khoo, NK; Lancaster, JR; Powell, PC; Richardson, GR; Tarpey, MM | 1 |
| Adães, S; Correia-de-Sá, P; Duarte-Araújo, M; Magalhães-Cardoso, T; Nascimento, C; Timóteo, MA; Vieira, C | 1 |
| Brennan, JD; Li, Y; Nutiu, R; Rupcich, N | 1 |
| Castro, LR; Cooper, DM; Fischmeister, R; Verde, I | 1 |
| Ashton, KJ; Blackburn, MR; Headrick, JP; Matherne, GP; Peart, JN; Reichelt, ME; Willems, L | 1 |
| Hirsch, S; Llanos, M; Ronco, AM; Tamayo, D | 1 |
| Baggott, JE; Morgan, SL | 1 |
| Antonioli, L; Blandizzi, C; Breschi, MC; Colucci, R; Da Settimo, F; Del Taca, M; Duranti, E; Fornai, M; Ghisu, N; Kastsiuchenka, O; La Motta, C; Mugnaini, L; Natale, G; Vassalle, C; Virdis, A | 1 |
| Kinoshita, T; Nakanishi, I; Tada, T | 1 |
| Bogo, MR; Bonan, CD; Dias, RD; Rico, EP; Rosemberg, DB; Senger, MR; Souza, DO | 1 |
| Sheppy, E; Wong, T; Wu, C; Wu, X; Zhang, L | 1 |
| Bardenheuer, H; Conzelmann, LO; Funke, B; Hofer, S; Kayhan, N; Schmidt, H; Steppan, J; Vahl, CF; Weigand, MA; Winkler, H | 1 |
| Dehghani Zadeh, A; Eldstrom, J; Fedida, D; Khurana, A; Loewen, ME; Steele, DF; Wang, Z | 1 |
| Tsai, NP; Tsui, YC; Wei, LN | 1 |
| Himeno, M; Suzuki, SO; Yamamoto, M | 1 |
| Campello-Costa, P; Maia, FB; Marques Ventura, AL; Oliveira-Silva, P; Paes-De-Carvalho, R; Serfaty, CA; Tavares Gomes, AL | 1 |
| Boison, D; Li, T; Shen, HY | 1 |
| Nishizaki, T; Saito, M; Yaguchi, T; Yasuda, Y | 1 |
| Matsumoto, K; Pham, NT; Tezuka, Y; Tohda, M | 1 |
| Li, G; Wang, J; Xu, L; Zhang, K; Zhu, X | 1 |
| Deng, P; Gong, X; Jiang, Y; Ming, X | 1 |
| Venton, BJ; Xu, Y | 1 |
| Antonioli, L; Awwad, O; Blandizzi, C; Colucci, R; Da Settimo, F; Duranti, E; Fornai, M; Ghisu, N; La Motta, C; Natale, G; Tuccori, M; Virdis, A | 1 |
| Abraham, A; Adams, DR; Allcock, RW; Baillie, GS; Baker, AH; Burton, P; Gilmour, J; Houslay, MD; Jiang, Z; Kane, NM; Kaupisch, A; McAbney, J; McCahill, A; Milligan, G; Mountford, JC | 1 |
| Adderley, SP; Bowles, EA; Ellsworth, ML; Sprague, RS; Sridharan, M; Stephenson, AH | 1 |
| Allen-Gipson, DS; Blackburn, MR; Bluitt, DL; Jarrell, JC; Schneider, DJ; Sisson, JH; Wyatt, TA; Yanov, D; Zhang, H | 1 |
| Biragyn, A; Ferrucci, L; Goetzl, EJ; Hesdorffer, CS; Kennedy, RT; Longo, DL; Mabrouk, OS; Madara, K; Malchinkhuu, E; Schwartz, JB; Taub, DD | 1 |
| Buyukdeligoz, M; Hocaoglu, N; Kalkan, S; Oransay, K; Tuncok, Y | 1 |
| Kimura, N; Okabayashi, S; Ono, F | 1 |
| Abd-Elfattah, AS; Ding, M; Jessen, ME; Wechsler, AS | 1 |
| Dobson, JG; Fenton, RA | 1 |
| Ivanov, A; Matsumura, I | 1 |
| Bartels, MJ; Geter, DR; Gollapudi, B; Jeong, YC; Schisler, MR; Wood, AJ; Zhang, F | 1 |
| Martins, DF; Mazzardo-Martins, L; Piovezan, AP; Santos, AR; Soldi, F; Stramosk, J | 1 |
| Inui, M; Morita, H; Murata, T; Okumura, K; Shimizu, K; Tagawa, T | 1 |
| Abd-Elfattah, AS; Brunsting, LA; Goldstein, JP; Jessen, ME; Salter, DR; Tuchy, GE; Wechsler, AS | 1 |
| Gulbins, E; Li, PL; Li, XX; Xia, M; Xiong, J; Xu, M; Zhang, Y | 1 |
| Antonioli, L; Awwad, O; Blandizzi, C; Brun, P; Caputi, V; Castagliuolo, I; Colucci, R; Fornai, M; Giron, MC; Giustarini, G; Pellegrini, C; Qesari, M; Scarpignato, C; Tuccori, M | 1 |
| Arai, N; Hiramoto, K; Inui, M; Manganiello, VC; Morita, H; Murata, T; Shimizu, K; Tagawa, T | 1 |
| Fathollahi, Y; Sadegh, M | 1 |
| Bernard, JJ; Li, T; Lou, YR; Lu, YP; Peng, QY | 1 |
| Fernández-Belda, F; Fuente, T; Handschin, C; Hernandez-Cascales, J; Pérez-Schindler, J; Soler, F | 1 |
| Bonan, CD; Bortolotto, JW; Cognato, Gde P; Melo, GM; Vianna, MR | 1 |
| Gotoh, A; Kanno, T; Kuribayashi, K; Nagaya, T; Nakajima, Y; Nakano, T; Nishizaki, T | 1 |
| Murzina, GB; Pivovarov, AS; Vasil'yeva, NA | 1 |
| Moretto, MB; Oliveira, MC; Pimentel, VC; Schetinger, MR; Sebastião, AM; Zanini, D | 1 |
| Ito, S; Kon, Y; Otsuguro, K; Otsuka, S; Tomonari, Y; Yamaguchi, S | 1 |
| Cheepala, SB; Frase, S; Fukuda, Y; Gartner, TK; Jackson, C; Pestina, T; Pitre, A; Schuetz, JD; Takenaka, K; Wang, Y; Zhang, Y | 1 |
| Faingold, CL; Kommajosyula, SP; Randall, ME | 1 |
| Carey, HV; Otis, JP; Pike, AC; Torrealba, JR | 1 |
| Ansari, S; Barawkar, DA; De, S; Deshpande, AM; Joshi, M; Kandalkar, SR; Mookhtiar, KA; Palle, VP; Raje, AA; Ramaiah, PA; Tambe, A; Waman, Y; Wavhal, A | 1 |
| Arya, A; Gupta, S; Singh, L | 1 |
| Aguirre, J; Blázquez-Bermejo, C; Cabrera-Pérez, R; Cámara, Y; Carreño-Gago, L; de la Cruz, X; Domínguez-González, C; García-Arumí, E; Lombès, A; Martí, R; Martín, MÁ; Molina-Granada, D; Ramón, J; Torres-Torronteras, J | 1 |
| Cerón, JJ; Contreras-Aguilar, MD; Escribano, D; Franco-Martínez, L; González-Arostegui, LG; Martín-Cuervo, M; Monkeviciene, I; Tecles, F; Tvarijonaviciute, A | 1 |
| Da Silva, RS; Lutte, AH; Majolo, JH | 1 |
| Gergs, U; Laufs, U; Neumann, J; Voss, R; Werner, C | 1 |
8 review(s) available for adenine and 9-(2-hydroxy-3-nonyl)adenine
| Article | Year |
|---|---|
Inhibitors of adenosine deaminase and the development of antiviral agents.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Cytarabine; Deoxyadenosines; Drug Synergism; Herpes Simplex; Humans; Interferons; Mice; Nucleoside Deaminases; S-Adenosylhomocysteine; S-Adenosylmethionine | 1985 |
Overview of possible relation of defects in purine metabolism to immune deficiency.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Cells, Cultured; Coformycin; Humans; Immunologic Deficiency Syndromes; Immunosuppressive Agents; Pentostatin; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors | 1985 |
The possible role of protein-carboxyl methylation in sperm motility and capacitation.
Topics: Adenine; Adenosine; Animals; Dyneins; Homocysteine; Humans; Infertility, Male; Male; Methylation; Mitochondria; Protein Methyltransferases; Protein O-Methyltransferase; Sperm Capacitation; Sperm Motility; Spermatogenesis; Spermatozoa; Testis | 1982 |
Cytomatrix in chromatophores.
Topics: Actins; Adenine; Adenosine Triphosphate; Animals; Biological Transport; Calcium; Cell Aggregation; Cell Movement; Chromatophores; Cytoplasm; Cytoskeleton; Dyneins; Fluorescent Antibody Technique; Intracellular Fluid; Microscopy, Electron; Microtubule-Associated Proteins; Microtubules; Models, Biological; Molecular Weight; Pigments, Biological; Proteins; Vanadium | 1984 |
Chemotaxis and methylation in a macrophage cell line.
Topics: Adenine; Adenosine; Animals; Blood Proteins; Cell Line; Chemotaxis, Leukocyte; Guinea Pigs; Humans; Macrophages; Methylation; Mice; Phosphatidylethanolamines; Rabbits; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1983 |
Metabolic intervention to affect myocardial recovery following ischemia.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Citric Acid Cycle; Coronary Circulation; Coronary Disease; Fructosediphosphates; Glucose; Glycogen; Heart; Humans; Inosine; Myocardium; Oxidative Phosphorylation; Ribonucleosides; Ribose | 1984 |
Does adenosine deaminase inhibition protect ischemic myocardium?
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Enzyme Inhibitors; Humans; In Vitro Techniques; Myocardial Ischemia; Pentostatin; Rabbits | 1994 |
Can adenosine deaminase inhibitors be cytoprotective agents?
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Astrocytoma; Enzyme Inhibitors; Humans; Kinetics; Spleen | 1998 |
1 trial(s) available for adenine and 9-(2-hydroxy-3-nonyl)adenine
| Article | Year |
|---|---|
Inhibition of adenosine deaminase to increase the antitumor activity of adenine nucleoside analogues.
Topics: Adenine; Adenosine Deaminase Inhibitors; Adult; Animals; Carcinoma, Ehrlich Tumor; Clinical Trials as Topic; Coformycin; DNA; Drug Evaluation; Drug Synergism; Humans; Leukemia P388; Leukemia, Experimental; Leukemia, Lymphoid; Male; Mice; Nucleoside Deaminases; Pentostatin; Thymidine; Vidarabine | 1985 |
407 other study(ies) available for adenine and 9-(2-hydroxy-3-nonyl)adenine
| Article | Year |
|---|---|
Possible role for 5'-nucleotidase in deoxyadenosine selective toxicity to cultured human lymphoblasts.
Topics: Adenine; B-Lymphocytes; Cell Line; Deoxyadenosines; Humans; Kinetics; Lymphocytes; Nucleotidases; T-Lymphocytes | 1979 |
Cyclic nucleotide levels and mechanism of inhibition of leucocyte function by adenosine deaminase inhibition.
Topics: Adenine; Adenosine Deaminase; Chemotaxis; Cyclic AMP; Deoxyadenosines; Homocysteine; Humans; Kinetics; Neutrophils; Nucleoside Deaminases; Phagocytosis | 1979 |
Purine ribonucleoside and deoxyribonucleoside metabolism in thymocytes.
Topics: Adenine; Animals; Deoxyribonucleosides; Kinetics; Magnesium; Mice; Phosphotransferases; Purine Nucleosides; Thymus Gland | 1979 |
Molecular mechanism(s) of deoxyribonucleoside toxicity in T-lymphoblasts.
Topics: Adenine; Deoxyadenosines; Deoxyguanosine; Deoxyribonucleosides; DNA; Humans; Hydroxyurea; Kinetics; T-Lymphocytes | 1979 |
Inhibition of immune cell function by adenosine: biochemical studies.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Adenosine; Animals; Cytotoxicity, Immunologic; Homocysteine; Imidazoles; Lymphocytes; Methionine; Mice; S-Adenosylmethionine; Theophylline; Uridine | 1979 |
Uptake of adenosine in human erythrocytes.
Topics: Adenine; Adenosine; Biological Transport; Erythrocytes; Humans; Kinetics; Temperature | 1979 |
Two approaches that increase the activity of analogs of adenine nucleosides in animal cells.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Deamination; Deoxyadenine Nucleotides; Deoxyadenosines; Dideoxynucleotides; DNA; Drug Synergism; L Cells; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nucleoside Deaminases; Phosphates; Purine Nucleosides; RNA; Thymidine; Uridine; Vidarabine | 1975 |
Adenosine receptor-induced cAMP changes in D384 astrocytoma cells and the effect of bradykinin thereon.
Topics: Adenine; Adenine Nucleotides; Astrocytoma; Bradykinin; Cyclic AMP; Dipyridamole; Humans; In Vitro Techniques; Phenylisopropyladenosine; Polyamines; Purinergic Antagonists; Receptors, Purinergic; Wasp Venoms; Xanthines | 1992 |
Adenosine deaminase inhibitors. Synthesis and biological evaluation of C1' and nor-C1' derivatives of (+)-erythro-9-(2(S)-hydroxy-3(R)-nonyl)adenine.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Binding Sites; Cattle; In Vitro Techniques; Stereoisomerism; Structure-Activity Relationship | 1992 |
Inhibition of adenosine metabolism increases myocardial interstitial adenosine concentrations and coronary flow.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Coronary Circulation; Extracellular Space; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Myocardium; Perfusion; Tubercidin; Vascular Resistance | 1992 |
Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Binding Sites; Hydrogen-Ion Concentration; Kinetics; Saccharomyces cerevisiae; Temperature | 1992 |
L1210/B23.1 cells express equilibrative, inhibitor-sensitive nucleoside transport activity and lack two parental nucleoside transport activities.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Carrier Proteins; Cell Membrane; Clone Cells; Formycins; Kinetics; Leukemia L1210; Membrane Proteins; Mice; Mutagenesis; Nucleoside Transport Proteins; Nucleosides; Thioinosine; Thymidine; Tumor Cells, Cultured; Vidarabine | 1992 |
Kinetics of inhibition of calf intestinal adenosine deaminase by (+)- and (-)-erythro-9-(2-hydroxy-3-nonyl)adenine.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Binding Sites; Cattle; Intestines; Kinetics; Mathematics; Spectrometry, Fluorescence; Spectrophotometry; Stereoisomerism | 1992 |
Measurement of rat plasma adenosine levels during normoxia and hypoxia.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Animals; Blood Pressure; Carbon Dioxide; Chromatography, High Pressure Liquid; Dipyridamole; Edetic Acid; Egtazic Acid; Hydrogen-Ion Concentration; Hypoxia; Male; Oxygen; Phosphorylation; Rats; Rats, Inbred Strains | 1992 |
Transport and metabolism of D-[3H]adenosine and L-[3H]adenosine in rat cerebral cortical synaptoneurosomes.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Biological Transport; Cerebral Cortex; Neurons; Rats; Stereoisomerism; Synaptosomes; Tritium; Tubercidin | 1992 |
Cardiac microdialysis in isolated rat hearts: interstitial purine metabolites during ischemia.
Topics: Adenine; Animals; Coronary Disease; Dialysis; Extracellular Space; In Vitro Techniques; Myocardium; Osmolar Concentration; Perfusion; Pressure; Purines; Rats | 1992 |
The precise radioimmunoassay of adenosine: minimization of sample collection artifacts and immunocrossreactivity.
Topics: Adenine; Adenosine; Artifacts; Automation; Chromatography, High Pressure Liquid; Cross Reactions; Humans; Immunosuppressive Agents; Molecular Structure; Radioimmunoassay; Sensitivity and Specificity; Temperature | 1992 |
Vanadate inhibits both intercellular adhesion and spreading on fibronectin of BHK21 cells and transformed derivatives.
Topics: Adenine; Animals; Cell Aggregation; Cell Communication; Cell Line, Transformed; Cell Movement; Cell Transformation, Viral; Clone Cells; Cricetinae; Dyneins; Fibronectins; Microtubules; Monensin; Ouabain; Phosphoprotein Phosphatases; Protein Tyrosine Phosphatases; Vanadates | 1991 |
Extracellular metabolism of adenine nucleotides and adenosine in the innervated skeletal muscle of the frog.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cations; Coformycin; Dipyridamole; In Vitro Techniques; Inosine Monophosphate; Kinetics; Muscles; Piperazines; Rana ridibunda; Sodium-Potassium-Exchanging ATPase; Thioinosine | 1991 |
Anabolic pathway of 6-methoxypurine arabinoside in cells infected with varicella-zoster virus.
Topics: 5'-Nucleotidase; Adenine; AMP Deaminase; Arabinonucleosides; Cells, Cultured; Fibroblasts; Herpesvirus 3, Human; Humans | 1991 |
Rat brain adenosine deaminase after 2'-deoxycoformycin administration: biochemical properties and evidence for reduced enzyme levels detected by 2'-[3H]deoxycoformycin ligand binding.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Brain; Cattle; Centrifugation, Density Gradient; Intestinal Mucosa; Ligands; Male; Pentostatin; Rats; Rats, Inbred Strains | 1992 |
Adenine nucleotide catabolism in the erythrocytes of uraemic patients.
Topics: Adenine; Adenine Nucleotides; AMP Deaminase; Anemia; Erythrocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Kinetics; Uremia | 1991 |
Effect of adenosine on the membrane potential changes of human neutrophils triggered by the tripeptide F-Met-Leu-Phe.
Topics: Adenine; Adenosine; Adenosine Deaminase; Calcium; Cell Membrane; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Kinetics; Membrane Potentials; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils | 1991 |
Adenine nucleotide degradation in cultured chick heart muscle cells.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Chick Embryo; Chromatography, High Pressure Liquid; Dipyridamole; Glycolysis; Inosine; Myocardium; Oxidative Phosphorylation; Phosphorylation; Thioinosine | 1991 |
The role of oxygen free radicals in myocardial ischemia/reperfusion injury.
Topics: Action Potentials; Adenine; Animals; Free Radical Scavengers; Guinea Pigs; Immunosuppressive Agents; In Vitro Techniques; Lipid Peroxides; Male; Malondialdehyde; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Oxygen; Papillary Muscles; Rabbits; Rats | 1991 |
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Cardiac Output; Coronary Circulation; Heart; Hypoxia; Inosine; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Ribonucleosides | 1991 |
Enhanced interstitial fluid adenosine attenuates myocardial stunning.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Coronary Disease; Dogs; Extracellular Space; Female; Hemodynamics; Male; Time Factors; Ventricular Function | 1991 |
Inhibitors of membrane lipid metabolism enhance complement-mediated nucleated cell killing through distinct mechanisms.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acylation; Adenine; Adenosine; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Complement C9; Complement Membrane Attack Complex; Complement System Proteins; Cytotoxicity, Immunologic; Flow Cytometry; Homocysteine; Immunosuppressive Agents; L-Lactate Dehydrogenase; Membrane Lipids; Methylation; Mice; Thimerosal | 1991 |
ATP derangement versus free radical-mediated injury.
Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Biological Transport; Free Radicals; Myocardial Reperfusion Injury; Thioinosine | 1991 |
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Intestines; Molecular Structure; Structure-Activity Relationship; Tubercidin | 1991 |
Deoxyadenosine reverses hydroxyurea inhibition of vaccinia virus growth.
Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Antiviral Agents; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Deoxyguanosine; Hydroxyurea; Ribonucleotide Reductases; Thymidine; Vaccinia virus; Viral Plaque Assay; Virus Replication | 1991 |
Inhibitors of membrane transmethylation reactions prevent the lymphocyte chemokinetic response.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Bradykinin; Chemotaxis, Leukocyte; Colchicine; Homocysteine; Humans; Interleukin-16; Leukocytes, Mononuclear; Lymphocytes; Lymphokines; Male; Membrane Lipids; Methylation; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Second Messenger Systems | 1990 |
Degradation of adenine nucleotides in the erythrocytes of patients with chronic renal failure.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Erythrocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Kidney Failure, Chronic; Reference Values | 1990 |
Role of AMP on the activation of glycogen synthase and phosphorylase by adenosine, fructose, and glutamine in rat hepatocytes.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Enzyme Activation; Fructose; Glutamine; Glycogen Synthase; Kinetics; Liver; Male; Models, Biological; Phosphorylase a; Phosphorylases; Rats; Rats, Inbred Strains | 1990 |
The protonated form of 1-N6-etheno-[erythro-9-(2-hydroxy-3-nonyl)] adenine is identified at the active site of adenosine deaminase.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Binding Sites; Binding, Competitive; Computers; Fluorescence Polarization; Hydrogen-Ion Concentration; Nucleoside Deaminases; Protons; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1990 |
Effect of ribonucleotide reductase inhibitors on the growth of human colon carcinoma HT-29 cells in culture.
Topics: Adenine; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Deoxyadenosines; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Isoquinolines; Pyrazoles; Ribonucleotide Reductases; Tumor Cells, Cultured | 1990 |
Species-dependent effects of adenosine on heart rate and atrioventricular nodal conduction. Mechanism and physiological implications.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Atrioventricular Node; Bundle of His; Depression, Chemical; Dipyridamole; Female; Guinea Pigs; Heart Atria; Heart Block; Heart Rate; Hypoxia; Male; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Xanthines | 1990 |
[Adenosine deaminase inhibitor (EHNA) on ischemia-reperfusion injury in isolated perfused rat hearts].
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Coronary Circulation; Heart Rate; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Inbred Strains; Ventricular Fibrillation | 1990 |
Is adenosine 5'-triphosphate derangement or free-radical-mediated injury the major cause of ventricular dysfunction during reperfusion? Role of adenine nucleoside transport in myocardial reperfusion injury.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Affinity Labels; Animals; Dogs; Female; Free Radicals; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Thioinosine; Ventricular Function, Left | 1990 |
Niacin prevents DNA strand breakage by adenosine deaminase inhibitors.
Topics: Adenine; Adenosine Deaminase Inhibitors; Cell Line; Cells, Cultured; DNA; DNA Damage; Flow Cytometry; Humans; Kinetics; Lymphocytes; Niacin; Nucleoside Deaminases; Pentostatin | 1990 |
A new method of sampling blood for measurement of plasma adenosine.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Blood Specimen Collection; Carbon Radioisotopes; Catheterization; Dipyridamole; Humans | 1990 |
Antineoplastic effect of the combination of 2,3-dihydro-1H-pyrazole[2,3a]imidazole plus deoxyadenosine/erythro-9-(2-hydroxyl-3-nonyl)adenine in mice with L1210 leukemia cells.
Topics: Adenine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyadenosines; Deoxyribonucleotides; Female; Flow Cytometry; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Pyrazoles | 1990 |
Automated enzymatic measurement of adenosine deaminase isoenzyme activities in serum.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Autoanalysis; Humans; Isoenzymes; Kinetics; Nucleoside Deaminases | 1990 |
Adenosine as adjunct to potassium cardioplegia: effect on function, energy metabolism, and electrophysiology.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Drug Combinations; Electrophysiology; Energy Metabolism; Heart; Heart Arrest, Induced; Potassium; Potassium Compounds; Rats | 1990 |
Protective effects of an adenosine deaminase inhibitor on ischemia-reperfusion injury in isolated perfused rat heart.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Coronary Circulation; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Nucleoside Deaminases; Perfusion; Rats; Rats, Inbred Strains; Rest; Ventricular Fibrillation | 1990 |
Endogenous adenosine restrains renin release in conscious rats.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Hydralazine; Hypertension, Renovascular; Male; Rats; Rats, Inbred Strains; Renin; Xanthines | 1990 |
cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Isoproterenol; Kinetics; Lipolysis; Male; Phenylisopropyladenosine; Protein Kinases; Rats; Rats, Inbred Strains; Seasons; Starvation | 1985 |
Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenine Nucleotides; Adenosine; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Immunoglobulin E; In Vitro Techniques; Male; Mast Cells; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Serotonin; Tachyphylaxis; Theophylline; Time Factors; Tubercidin | 1986 |
A1 and A2 adenosine receptors regulate adenylate cyclase in cultured human lung fibroblasts.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Line; Cyclic AMP; Fibroblasts; Humans; Lung; Receptors, Cell Surface; Receptors, Purinergic; Theophylline; Virulence Factors, Bordetella | 1986 |
Neuritic transport of herpes simplex virus in rat sensory neurons in vitro. Effects of substances interacting with microtubular function and axonal flow [nocodazole, taxol and erythro-9-3-(2-hydroxynonyl)adenine].
Topics: Adenine; Alkaloids; Animals; Axonal Transport; Axons; Benzimidazoles; Cells, Cultured; Lectins; Microtubules; Neurons, Afferent; Nocodazole; Paclitaxel; Rats; Simplexvirus; Virus Replication; Wheat Germ Agglutinins | 1986 |
Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Animals; Calcium Channel Blockers; Dinoprostone; Felodipine; Female; Gallic Acid; Methylation; Mice; Monensin; Nifedipine; Nitrendipine; Pregnancy; Prostaglandins E; Thromboplastin; Trophoblasts; Tubercidin; Verapamil | 1986 |
Effects of alkylxanthines and calcium antagonists on adenosine uptake by cultured rabbit coronary microvascular endothelium.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Calcium Channel Blockers; Cells, Cultured; Coronary Vessels; Dipyridamole; Endothelium; Ethanol; Isoproterenol; Male; Microcirculation; Rabbits; Theophylline; Trifluoperazine; Xanthines | 1987 |
Cordycepin rapidly collapses the intermediate filament networks into juxtanuclear caps in fibroblasts and epidermal cells.
Topics: Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Cricetinae; Cytoskeleton; Deoxyadenine Nucleotides; Deoxyadenosines; Epidermis; Fibroblasts; Intermediate Filaments; Interphase; Keratins; Vanadates; Vimentin | 1988 |
Evaluation of the effects of erythro-9(2-hydroxy-3-nonyl) adenine (EHNA) on HIV-1 production in vitro.
Topics: Adenine; Adenosine Deaminase Inhibitors; Antiviral Agents; Cell Line; Deoxycytidine; Drug Synergism; Flow Cytometry; HIV Envelope Protein gp120; HIV-1; RNA-Directed DNA Polymerase; Virus Replication | 1989 |
[Role of hypothalamic adenosinergic systems in regulating states of wakefulness in the rat].
Topics: Adenine; Adenosine; Animals; Hypothalamus; Hypothalamus, Posterior; Immunosuppressive Agents; Male; Piperazines; Rats; Rats, Inbred Strains; Sleep; Wakefulness | 1989 |
Quantitation of the dynein pool in unfertilized sea urchin eggs.
Topics: Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Blastocyst; Centrifugation, Density Gradient; Chromatography, Ion Exchange; Cilia; Cytoplasm; Dyneins; Electrophoresis, Polyacrylamide Gel; GTP Phosphohydrolases; Molecular Weight; Ovum; Photochemistry; Sea Urchins; Vanadates | 1989 |
Imbalance of purine nucleotides in alanosine-resistant baby hamster kidney cells.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Kinase; Adenylosuccinate Lyase; Adenylosuccinate Synthase; Alanine; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cricetinae; Culture Media; Humans; Hypoxanthine Phosphoribosyltransferase; Mutation; Phosphotransferases; Purines; Selection, Genetic; Transformation, Genetic; Uridine | 1989 |
Turnover of adenosine in plasma of human and dog blood.
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosylhomocysteinase; Animals; Blood Flow Velocity; Dipyridamole; Dogs; Forearm; Half-Life; Humans; Hydrolases; Nucleotidases; Tritium | 1989 |
Interleukin 2 responsive lymphocytes in patients with adenosine deaminase deficiency.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; CD4-Positive T-Lymphocytes; Deoxyadenosines; Drug Synergism; Humans; Immunologic Deficiency Syndromes; Interleukin-2; Leukocytes, Mononuclear; Lymphocyte Activation; Mitogens; Models, Biological; Nucleoside Deaminases; Recombinant Proteins | 1989 |
Transendothelial transport and metabolism of adenosine and inosine in the intact rat aorta.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aorta; Endothelium, Vascular; Female; Inosine; Male; Muscle, Smooth, Vascular; Purines; Rats; Rats, Inbred Strains; Tritium | 1989 |
Inhibitors of adenosine catabolism improve recovery of dog myocardium after ischemia.
Topics: Adenine; Adenosine; Animals; Dipyridamole; Dogs; Drug Combinations; Energy Metabolism; Female; Free Radicals; Male; Myocardial Contraction; Myocardial Reperfusion Injury | 1989 |
Contribution of S-adenosylhomocysteine to cardiac adenosine formation.
Topics: Adenine; Adenosine; Animals; Guinea Pigs; Heart; Homocysteine; In Vitro Techniques; Kinetics; Models, Theoretical; Myocardium; Perfusion; S-Adenosylhomocysteine | 1989 |
Adenosine deaminase and adenosine uptake inhibitions facilitate ventilation in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Carotid Arteries; Carotid Body; Chemoreceptor Cells; Dipyridamole; Injections; Nucleoside Deaminases; Rats; Rats, Inbred Strains; Respiration; Stimulation, Chemical; Xanthines | 1989 |
Laser photobleaching leads to a fluorescence grade adenosine deaminase.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Kinetics; Lasers; Nucleoside Deaminases; Photochemistry; Polarography; Spectrometry, Fluorescence | 1989 |
Inhibition of phosphoinositide metabolism in human polymorphonuclear leukocytes by S-adenosylhomocysteine.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Homocysteine; Humans; In Vitro Techniques; Kinetics; Neutrophils; Phosphatidylinositols; S-Adenosylhomocysteine; Type C Phospholipases | 1988 |
Absolute rates of adenosine formation during ischaemia in rat and pigeon hearts.
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase; Adenosine Kinase; Adult; AMP Deaminase; Animals; Columbidae; Coronary Disease; Female; Heart; Histocytochemistry; Humans; Male; Middle Aged; Myocardium; Nucleotidases; Nucleotides; Phosphoric Monoester Hydrolases; Rats; Rats, Inbred Strains; Species Specificity; Tubercidin | 1988 |
Purine and pyrimidine metabolism in human muscle and cultured muscle cells.
Topics: 5'-Nucleotidase; Adenine; Adenosine Deaminase; Adult; Aged; AMP Deaminase; Cells, Cultured; Humans; Middle Aged; Muscles; Nucleotidases; Purines; Pyrimidines | 1988 |
Cross-resistance patterns in hydroxyurea-resistant leukemia L1210 cells.
Topics: Adenine; Animals; Cell Line; Drug Resistance; Electron Spin Resonance Spectroscopy; Guanidines; Hydroxyurea; Isoquinolines; Leukemia L1210; Pyrazoles; Ribonucleotide Reductases | 1988 |
Erythro-9-[3-(2-hydroxynonyl)]adenine and vanadate as probes for microtubule-based cytoskeletal mechanochemistry.
Topics: Actins; Adenine; Adenosine Deaminase Inhibitors; Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cytoskeleton; Dyneins; Microtubules; Vanadates; Vanadium | 1986 |
Regulation of macrophage lysosomal secretion by adenosine, adenosine phosphate esters, and related structural analogues of adenosine.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Esterases; Homocysteine; Kinetics; Lysosomes; Macrophages; Male; Mice; Receptors, Cell Surface; Receptors, Purinergic; Secretory Rate; Structure-Activity Relationship; Theophylline; Tubercidin | 1985 |
Purine metabolizing enzymes of lymphocyte cell populations: correlation between AMP-deaminase activity and dATP accumulation in murine lymphocytes.
Topics: 5'-Nucleotidase; Adenine; Adenosine Monophosphate; AMP Deaminase; Animals; Bone Marrow; Cells, Cultured; Coformycin; Cytoplasm; Deoxyadenine Nucleotides; Deoxyadenosines; Humans; Lymph Nodes; Lymphocytes; Male; Mice; Nucleotidases; Nucleotide Deaminases; Pentostatin; Phosphotransferases; Spleen; Thymus Gland | 1985 |
Adenosine receptor-mediated changes in cyclic AMP production and DNA synthesis in cultured arterial smooth muscle cells.
Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; DNA Replication; Muscle, Smooth, Vascular; Phenylisopropyladenosine; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic | 1985 |
Adenosine inhibits prolactin and growth hormone secretion in a clonal pituitary cell line.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Carbachol; Cell Line; Chromatography, High Pressure Liquid; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Dipyridamole; Growth Hormone; Phenylisopropyladenosine; Pituitary Gland; Pituitary Neoplasms; Prolactin; Rats; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide | 1985 |
Adenosine is unimportant in controlling coronary blood flow in unstressed dog hearts.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Coronary Circulation; Dogs; Female; Hemodynamics; Histamine; Lymph; Male; Mathematics; Receptors, Cell Surface; Receptors, Purinergic; Regional Blood Flow; Substrate Specificity; Vasodilation | 1985 |
Role of adenosine deaminase in human monocyte differentiation and tumor cell cytotoxicity.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Antibody-Dependent Cell Cytotoxicity; Carcinoma, Transitional Cell; Cell Differentiation; Cell Line; Cytotoxicity, Immunologic; Homocysteine; Humans; Lymphokines; Macrophage Activation; Monocytes; Nucleoside Deaminases; Phagocytosis; Superoxides; Urinary Bladder Neoplasms | 1985 |
Calcium entry blocking activity of dilazep in dog coronary artery.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Arteries; Azepines; Calcium; Calcium Channel Blockers; Coronary Vessels; Dilazep; Diltiazem; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Lidoflazine; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Receptors, Cell Surface; Receptors, Purinergic; Theophylline | 1986 |
The influence of inhibitors of the ATP degradative pathway on recovery of function and high energy phosphate after transient ischemia in the rat heart.
Topics: 5'-Nucleotidase; Acute Disease; Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Triphosphate; Adenylate Kinase; Animals; Coronary Circulation; Coronary Disease; Dinucleoside Phosphates; Male; Nucleotidases; Rats; Rats, Inbred Strains; Thioinosine | 1986 |
Activation of hepatocyte glycogen synthase by metabolic inhibitors.
Topics: 2,4-Dinitrophenol; Adenine; Adenine Nucleotides; Animals; Atractyloside; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dinitrophenols; Enzyme Activation; Glycogen Synthase; Inosine Monophosphate; Liver; Phosphorylases; Rats | 1986 |
Myocardial reperfusion injury. Role of myocardial hypoxanthine and xanthine in free radical-mediated reperfusion injury.
Topics: Adenine; Adenine Nucleotides; Animals; Coronary Disease; Dogs; Female; Free Radicals; Heart; Heart Ventricles; Hypoxanthine; Hypoxanthines; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Thioinosine; Xanthine; Xanthines | 1988 |
Synergistic effect of 3'-deoxyadenosine N1-oxide and adenosine deaminase inhibitors on growth of Ehrlich ascites tumor cells in vivo.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Drug Resistance; Drug Synergism; Female; Mice; Nucleoside Deaminases; Pentostatin; Ribonucleosides | 1988 |
Cordycepin disrupts the microtubule networks and arrests Nil 8 hamster fibroblasts at the onset of mitosis.
Topics: Adenine; Adenosine Triphosphate; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Fibroblasts; Fluorescent Antibody Technique; Microscopy, Electron; Microtubule Proteins; Microtubules; Mitosis; Phosphorylation; Spindle Apparatus | 1987 |
Methionine-induced positive inotropic effect in rat heart: possible role of phospholipid N-methylation.
Topics: Adenine; Animals; Calcium; Dose-Response Relationship, Drug; Male; Methionine; Myocardial Contraction; Phospholipids; Rats; Rats, Inbred Strains; Ryanodine | 1988 |
Adenosine deaminase inhibitors. Synthesis and biological activity of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Antiviral Agents; Drug Synergism; Humans; Mice; Nucleoside Deaminases; Structure-Activity Relationship; Vidarabine | 1988 |
Adenosine handling in interstitia of cremaster muscle studied by bioassay.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arterioles; Biological Assay; Cricetinae; Diffusion; Dipyridamole; Extracellular Space; Kinetics; Methods; Muscles; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Thioinosine; Vasodilation | 1988 |
Modulation of cell nucleotide levels of isolated kidney tubules.
Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Triphosphate; Animals; Biomechanical Phenomena; Extracellular Space; Female; Glycerophosphates; In Vitro Techniques; Kidney Tubules; Nucleosides; Nucleotides; Purines; Rabbits | 1988 |
Inhibition of methyltransferase reduces the turnover of acetylcholine receptors.
Topics: Adenine; Adenosine; Animals; Dose-Response Relationship, Drug; Endocytosis; Homocysteine; In Vitro Techniques; Methionine; Methyltransferases; Muscles; Myasthenia Gravis; Phospholipids; Rats; Receptors, Nicotinic | 1988 |
Implication of protein carboxymethylation in retinal pigment epithelial cell chemotaxis.
Topics: Adenine; Adenosine; Chemotaxis; Eye Proteins; Fibronectins; Homocysteine; Humans; Hydrolysis; Methanol; Pigment Epithelium of Eye; Platelet-Derived Growth Factor; Protein Methyltransferases; Protein O-Methyltransferase | 1988 |
Inhibition of T cell cytotoxicity by cyclosporine (CSA), adenosine (Ado) and an inhibitor of adenosine deaminase (ADA).
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Cyclosporins; Cytotoxicity, Immunologic; Drug Synergism; In Vitro Techniques; Male; Mice; T-Lymphocytes, Cytotoxic | 1986 |
Isolation of mutant adenosine deaminase by coformycin affinity chromatography.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Cell Line; Chromatography, Affinity; Coformycin; Humans; Lymphocytes; Mutation; Nucleoside Deaminases; Pentostatin | 1986 |
Enhancement of biotinidase activity in mouse serum by inhibitors of methylation.
Topics: Adenine; Adenosine; Amidohydrolases; Animals; Biotinidase; Coformycin; Ethionine; Female; Liver; Methylation; Mice; Pentostatin; Vidarabine | 1987 |
Degradation of AMP in erythrocytes of man. Evidence for a cytosolic phosphatase activity.
Topics: Acid Phosphatase; Adenine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Monophosphate; Chromatography, Gel; Coformycin; Cytosol; Deoxyadenosines; Erythrocytes; Humans; Hydrogen-Ion Concentration | 1987 |
Motility in the siphonous green alga Bryopsis. II. Chloroplast movement requires organized arrays of both microtubules and actin filaments.
Topics: Actin Cytoskeleton; Actins; Adenine; Chlorophyta; Chloroplasts; Colchicine; Cold Temperature; Cytochalasins; Fluorescent Antibody Technique; Lumicolchicines; Microtubules; Movement; Nitrobenzenes; Organothiophosphorus Compounds; Vinblastine | 1986 |
Measurement of plasma adenosine concentration: methodological and physiological considerations.
Topics: Adenine; Adenosine; Dipyridamole; Erythrocytes; False Positive Reactions; Hemolysis; Humans; Indicators and Reagents; Radioisotope Dilution Technique; Tritium | 1987 |
Transient increase in release of adenosine during rapid cardiac pacing; transient effects on overdrive suppression of ventricular automaticity.
Topics: Adenine; Adenosine; Animals; Cardiac Pacing, Artificial; Electrocardiography; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Oxygen Consumption; Rats; Rats, Inbred Strains; Theophylline | 1987 |
Erythro-9-[3-(2-hydroxynonyl)]adenine accelerates actin polymerization and nucleotide exchange.
Topics: Actin Cytoskeleton; Actins; Adenine; Adenosine Triphosphate; Animals; Kinetics; Polymers; Spectrometry, Fluorescence; Viscosity | 1986 |
Reactivation of organelle movements along the cytoskeletal framework of a giant freshwater ameba.
Topics: Actin Cytoskeleton; Adenine; Adenosine Triphosphate; Amoeba; Animals; Cytoplasm; Cytoskeleton; Dithiothreitol; Ethylmaleimide; Microtubules; Motion Pictures; Movement; Organoids; Vanadium | 1986 |
Inhibition of macrophage phagocytosis by methylation inhibitors. Lack of correlation of protein carboxymethylation and phospholipid methylation with phagocytosis.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Deoxyadenosines; Homocysteine; Kinetics; Macrophages; Methylation; Mice; Phagocytosis; Phospholipids; Proteins; Vidarabine | 1985 |
Antagonism of the positive chronotropic effect of norepinephrine by purine nucleosides in rat atria.
Topics: Adenine; Adenosine; Animals; Deoxyadenosines; Heart Atria; Heart Rate; Inosine; Male; Norepinephrine; Phenylisopropyladenosine; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1985 |
Adenosine deaminase inhibitors enhance cerebral anoxic hyperemia in the rat.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Brain; Cerebrovascular Circulation; Coformycin; Hyperemia; Hypoxia, Brain; Male; Pentostatin; Rats; Rats, Inbred Strains; Ribonucleosides | 1985 |
Inhibition of antibody production by 2-chloroadenosine.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; DNA Replication; Homocysteine; Immunosuppressive Agents; Lymphocyte Activation; Male; Methylation; Mice; S-Adenosylmethionine | 1985 |
Adenosine and hypoxic vasodilatation.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cerebrovascular Circulation; Coformycin; Dogs; Hypoxia; Nucleoside Deaminases; Pentostatin; Rats; Ribonucleosides; Vasodilation | 1985 |
Effects of adenosine deaminase inhibitors on lymphocyte-mediated cytolysis.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Line; Coformycin; Cytotoxicity, Immunologic; Immunity, Cellular; Immunosuppressive Agents; Leukemia; Mice; Nucleoside Deaminases; Pentostatin; T-Lymphocytes, Cytotoxic | 1985 |
An experimental evaluation of nucleotide enhancement techniques for kidney transplantation.
Topics: Adenine; Adenosine; Animals; Dipyridamole; Dogs; Female; Graft Survival; Kidney; Kidney Transplantation; Nucleotides; Organ Preservation; Transplantation, Autologous | 1985 |
An analysis of multiple mechanisms of adenosine toxicity in baby hamster kidney cells.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cell Adhesion; Cell Line; Coformycin; Drug Resistance; Drug Synergism; Guinea Pigs; Homocysteine; Kidney; Nucleotides; Pentostatin; Ribonucleotide Reductases; S-Adenosylhomocysteine; Uridine | 1985 |
Relevance of adenosine deaminase to organ transplantation.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Coformycin; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nucleoside Deaminases; Pentostatin; Skin Transplantation; Splenectomy; T-Lymphocytes; Vidarabine | 1985 |
Adenosine deaminase impairment and ribonucleotide reductase in human cells.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Cell Division; Deoxyadenosines; HeLa Cells; Humans; Interphase; Nucleoside Deaminases; Ribonucleotide Reductases; Thymine Nucleotides | 1985 |
Inhibition of adenosine deaminase from several sources by deaza derivatives of adenosine and EHNA.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Antiviral Agents; Erythrocytes; Escherichia coli; Humans; Kinetics; Nucleoside Deaminases; Saccharomyces cerevisiae; Structure-Activity Relationship | 1985 |
EHNA is a poor inhibitor of deoxyadenosine catabolism in cultured human lymphocytes.
Topics: Adenine; Adenine Phosphoribosyltransferase; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Cell Line; Deoxyadenosines; Dose-Response Relationship, Drug; Humans; Hypoxanthine Phosphoribosyltransferase; Immunologic Deficiency Syndromes; Kinetics; Lesch-Nyhan Syndrome; Lymphocytes; Nucleoside Deaminases; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Research Design | 1985 |
Adenosine deaminase inhibition and myocardial adenosine metabolism during ischemia.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Coronary Circulation; Coronary Disease; Inosine Monophosphate; Male; Myocardial Contraction; Myocardium; Nucleoside Deaminases; Purines; Rats; Rats, Inbred Strains | 1985 |
An early effect of the S component of staphylococcal leukocidin on methylation of phospholipid in various leukocytes.
Topics: Adenine; Adenosine; Animals; Cell Survival; Enzyme Activation; Homocysteine; Leukocidins; Membrane Lipids; Methylation; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Rabbits; Staphylococcus | 1985 |
Adenosine deaminase inhibition and myocardial purine release during normoxia and ischaemia.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Monophosphate; Animals; Coronary Circulation; Deamination; Depression, Chemical; Heart; Male; Myocardium; Nucleoside Deaminases; Oxygen Consumption; Perfusion; Purines; Rats; Rats, Inbred Strains | 1985 |
Adenosine inhibits cell division and promotes neurite extension in PC12 cells.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenylyl Cyclases; Animals; Axons; Cell Division; Cell Line; Cyclic AMP; Drug Synergism; Nerve Growth Factors; Neurons; Receptors, Cell Surface; Receptors, Purinergic | 1984 |
Adenosine A2 receptors on human monocytes modulate C2 production.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Complement C2; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Monocytes; Phenylisopropyladenosine; Receptors, Cell Surface; Receptors, Purinergic; Tubercidin | 1984 |
A new physiological function for adenosine: regulation of superoxide anion production.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Anions; Calcimycin; Concanavalin A; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
Selective inhibition by NPT 15392 of lymphocyte cyclic GMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Adjuvants, Immunologic; Animals; Hypoxanthines; Lymphocytes; Male; Mice; Mice, Inbred Strains | 1984 |
Control of transmitter release in guinea-pig vas deferens by prejunctional P1-purinoceptors.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Triphosphate; Animals; Dipyridamole; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neurotransmitter Agents; Norepinephrine; Receptors, Neurotransmitter; Receptors, Purinergic; Theophylline; Vas Deferens | 1984 |
Effect of inhibitors of transmethylation on histamine release from human basophils.
Topics: Adenine; Adenosine; Basophils; Calcimycin; Histamine Release; Homocysteine; Humans; Immunoglobulin E; In Vitro Techniques; Methylation; Ribonucleosides; S-Adenosylmethionine; Tubercidin | 1981 |
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
Topics: Adenine; Adenosine; Animals; Basophils; Female; Histamine Release; Homocysteine; Immunoglobulin E; Leukemia; Mast Cells; Methylation; Mice; Rabbits; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
Hepatocyte targeting of adenine-9-beta-D-arabinofuranoside 5' -monophosphate (ara-AMP) coupled to lactosaminated albumin.
Topics: Adenine; Amino Sugars; Animals; Arabinonucleotides; DNA, Viral; Ectromelia, Infectious; Female; Immunosuppressive Agents; Liver; Mice; Nucleic Acid Hybridization; Serum Albumin; Structure-Activity Relationship; Vidarabine Phosphate | 1981 |
Effects of adenosine and deoxyadenosine on PHA-stimulation of lymphocytes of man, horse and pig.
Topics: Adenine; Adenosine; Adult; Animals; Deoxyadenosines; Horses; Humans; In Vitro Techniques; Lymphocytes; Phosphoribosyl Pyrophosphate; Phytohemagglutinins; Species Specificity; Swine; Thymidine; Uridine | 1982 |
Effect of inhibitors of methylation on early and late interferon synthesis in bovine kidney cell cultures.
Topics: Adenine; Adenosine; Animals; Cattle; Cells, Cultured; Cycloheximide; Cycloleucine; Homocysteine; Interferons; Methylation; Newcastle disease virus; Poly I-C; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Terminal incorporation of 2'-deoxyadenosine into polyadenylate segments of polyadenylated RNA in G1-phase-arrested human T-lymphoblasts.
Topics: Adenine; Cell Line; Chromatography, High Pressure Liquid; Cytoplasm; Deoxyadenosines; Flow Cytometry; Humans; Interphase; Leukemia, Lymphoid; Poly A; RNA; RNA, Messenger; T-Lymphocytes | 1983 |
Selective inhibition of retrograde axonal transport by erythro-9-[3-(2-hydroxynonyl)]adenine.
Topics: Adenine; Adenosine Triphosphate; Animals; Axonal Transport; Nephropidae; Organoids | 1983 |
The effect of methyltransferase inhibitors on histamine release from human dispersed lung mast cells activated with anti-human IgE and calcium ionophore A23187.
Topics: Adenine; Adenosine; Antibodies, Anti-Idiotypic; Calcimycin; Histamine Release; Humans; Immunoglobulin E; Mast Cells; Membrane Lipids; Methylation; Methyltransferases; Phospholipids; Ribonucleosides; S-Adenosylmethionine; Tubercidin | 1984 |
Inhibition of fast axonal transport by erythro-9-[3-(2-hydroxynonyl)]adenine.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Axonal Transport; Cycloleucine; Deoxyadenosines; Rana esculenta; Rana temporaria; Sciatic Nerve; Thionucleosides | 1984 |
Pigment particle translocation in detergent-permeabilized melanophores of Fundulus heteroclitus.
Topics: Adenine; Animals; Biological Transport; Cell Membrane Permeability; Cetomacrogol; Cytoplasmic Granules; Cytoskeleton; Detergents; Dyneins; Epinephrine; Killifishes; Melanophores; Microtubules; Vanadium | 1982 |
ATP reactivation of the rotary axostyle in termite flagellates: effects of dynein ATPase inhibitors.
Topics: Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Dyneins; Eukaryota; Flagella; Insecta; Microtubules; Movement; Sulfhydryl Reagents; Vanadates; Vanadium | 1982 |
Effect of extraction time on ability of calmodulin to activate 30S and 14S dynein ATPases.
Topics: Adenine; Adenosine Triphosphatases; Calmodulin; Chromatography, Affinity; Cilia; Dyneins; Enzyme Activation; Tetrahymena pyriformis; Time Factors; Vanadates; Vanadium | 1984 |
Effects of exogenous adenosine deaminase and erythro-9-(2-hydroxy-3-nonyl) adenine on intracellular cyclic AMP levels in C1300 murine neuroblastoma in tissue culture.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Cell Line; Culture Techniques; Cyclic AMP; Dipyridamole; Mice; Neoplasms, Experimental; Neuroblastoma; Nucleoside Deaminases; Theophylline | 1980 |
Adenosine transport by a variant of C1300 murine neuroblastoma cells deficient in adenosine kinase.
Topics: Adenine; Adenosine; Adenosine Kinase; Animals; Biological Transport; Cell Line; Genetic Variation; Kinetics; Mice; Neuroblastoma; Phosphotransferases; Purines; Structure-Activity Relationship | 1980 |
Erythro-9-(2-hydroxy-3-nonyl) Adenine alone and in combination with 9-beta-D-arabinofuranosyladenine in treatment of systemic herpesvirus infections in mice.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Antiviral Agents; Drug Synergism; Drug Therapy, Combination; Female; Herpes Simplex; Mice; Nucleoside Deaminases; Simplexvirus; Vidarabine | 1980 |
Levels of adenosine deaminase AMP deaminase, and adenylate kinase in cultured human lymphoblast lines: exquisite sensitivity of AMP deaminase to adenosine deaminase inhibitors.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenylate Kinase; AMP Deaminase; Cells, Cultured; Coformycin; Humans; Lymphocytes; Nucleoside Deaminases; Nucleotide Deaminases; Pentostatin; Phosphotransferases | 1981 |
Inhibition of lymphocyte-mediated cytolysis and cyclic AMP phosphodiesterase by erythro-9-(2-hydroxy-3-nonyl)adenine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenylyl Cyclases; Animals; Immunosuppressive Agents; In Vitro Techniques; Mice; S-Adenosylhomocysteine; T-Lymphocytes, Cytotoxic | 1982 |
Effect of inhibition of purine enzymes on benzodiazepine binding in the human brain.
Topics: Adenine; Adenosine Deaminase Inhibitors; Aged; Aminohydrolases; Aminoimidazole Carboxamide; Benzodiazepines; Brain; Flunitrazepam; Guanine Deaminase; Humans; Imidazoles; Kinetics; Male; Middle Aged; Nucleoside Deaminases; Organ Specificity; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Cytotoxicity of arabinofuranosyladenine and erythro-9-(2-hydroxy-3-nonyl) adenine to Epstein-Barr virus producer and nonproducer lymphoma cells in culture.
Topics: Adenine; Animals; Burkitt Lymphoma; Callitrichinae; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Genes, Viral; Herpesvirus 4, Human; Humans; Infectious Mononucleosis; Neoplasms, Experimental; Vidarabine | 1983 |
Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Calcimycin; Cell Aggregation; Coformycin; Cytochalasin B; Cytoplasmic Granules; Depression, Chemical; Dipyridamole; Humans; Methylation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentostatin; Superoxides | 1983 |
Effects of chirality in 9-(2-hydroxy-3-nonyl)adenine upon deoxyribonucleic acid synthesis in herpes simplex virus-infected cells.
Topics: Adenine; Antiviral Agents; Deoxyribonucleotides; DNA Replication; DNA, Viral; Nucleic Acid Synthesis Inhibitors; Simplexvirus; Stereoisomerism; Virus Replication | 1983 |
Inhibition of herpes simplex virus replication by purine deoxyribonucleosides.
Topics: Adenine; Deoxyadenosines; Deoxyguanosine; Deoxyribonucleosides; DNA Replication; HeLa Cells; Humans; Kinetics; Purine Nucleosides; Simplexvirus; Structure-Activity Relationship; Virus Replication | 1984 |
Cyclosporine-induced adenosine triphosphate depletion in murine T and B lymphocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; B-Lymphocytes; Cell Separation; Chromatography, High Pressure Liquid; Cyclosporins; Female; Fluorescent Antibody Technique; Mice; Mice, Inbred C57BL; Spleen; T-Lymphocytes | 1984 |
erythro-9-[3-(2-Hydroxynonyl)]adenine is an effective inhibitor of cell motility and actin assembly.
Topics: Actins; Adenine; Animals; Cell Line; Cell Movement; Chickens; Chlorocebus aethiops; Immunosuppressive Agents; Kidney; Kinetics; Macromolecular Substances; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Muscles | 1984 |
Effects of biochemical modulation of drug combinations directed at the ribonucleotide reductase site on leukemia L1210 cell growth in culture.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cells, Cultured; Deferoxamine; Deoxyadenosines; Drug Synergism; Hydroxyurea; Leukemia L1210; Pyrazoles; Ribonucleotide Reductases | 1983 |
Sedative and electroencephalographic actions of erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA): relationship to inhibition of brain adenosine deaminase.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Brain; Brain Chemistry; Electroencephalography; Hypnotics and Sedatives; Male; Motor Activity; Nucleoside Deaminases; Rats; Rats, Inbred Strains | 1983 |
Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.
Topics: Adenine; Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Guanidines; Male; Mice; Mice, Nude; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostatic Neoplasms; Rats; Vidarabine | 1984 |
B cells as well as T cells form deoxynucleotides from either deoxyadenosine or deoxyguanosine.
Topics: Adenine; Adenosine Deaminase Inhibitors; B-Lymphocytes; Cell Line; Cell Survival; Coformycin; Deoxyadenine Nucleotides; Deoxyadenosines; Deoxyguanine Nucleotides; Deoxyguanosine; Dose-Response Relationship, Drug; Guanosine; Humans; Pentostatin; Purine-Nucleoside Phosphorylase; T-Lymphocytes | 1984 |
Localized surface antigens of guinea pig sperm migrate to new regions prior to fertilization.
Topics: 2,4-Dinitrophenol; Acrosome; Adenine; Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Antigens, Surface; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Dinitrophenols; Fertilization; Fluorescent Antibody Technique; Guinea Pigs; Male; Sperm Motility; Spermatozoa | 1984 |
erythro-9-[3-(2-Hydroxynonyl)]adenine is an inhibitor of sperm motility that blocks dynein ATPase and protein carboxylmethylase activities.
Topics: Adenine; Adenosine Triphosphatases; Animals; Dyneins; Humans; Immunosuppressive Agents; Kinetics; Male; Protein Methyltransferases; Protein O-Methyltransferase; Rabbits; Rats; Sea Urchins; Species Specificity; Sperm Motility; Spermatozoa | 1981 |
Inhibition of spindle elongation in permeabilized mitotic cells by erythro-9-[3-(2-hydroxynonyl)] adenine.
Topics: Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Anaphase; Animals; Cells, Cultured; Dyneins; Microtubules; Mitosis | 1982 |
Inhibitors of dynein activity block intracellular transport in erythrophores.
Topics: Adenine; Adenosine Triphosphatases; Animals; Cell Compartmentation; Chromatophores; Dyneins; Fishes; Microtubules; S-Adenosylhomocysteine; Vanadates; Vanadium | 1982 |
Dynein ATPase is inhibited selectively in vitro by erythro-9-[3-2-(hydroxynonyl)]adenine.
Topics: Actomyosin; Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Dyneins; Immunosuppressive Agents; Kinetics; Male; Myosins; Sea Urchins; Spermatozoa | 1982 |
Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminophylline; Animals; Atrioventricular Node; Atropine; Dipyridamole; Dose-Response Relationship, Drug; Electrophysiology; Guinea Pigs; Heart Block; Heart Conduction System; In Vitro Techniques; Nucleosides; Time Factors | 1984 |
Correlations between phospholipid methylation and neuronal catecholamine transport.
Topics: Adenine; Adenosine; Animals; Biological Transport; Cerebral Cortex; Cytosol; Homocysteine; Kinetics; Male; Membrane Lipids; Methylation; Norepinephrine; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; Synaptosomes | 1984 |
Purinogenic lymphocytotoxicity: clues to a wider chemotherapeutic potential for the adenosine deaminase inhibitors.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Cell Survival; Cells, Cultured; Coformycin; Deoxyadenosines; Humans; Interphase; Leukemia; Lymphopenia; Nucleoside Deaminases; Pentostatin; Purines; Ribonucleosides; T-Lymphocytes | 1983 |
Regulation of thymocyte proliferation by endogenous adenosine and adenosine deaminase.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Cells, Cultured; Dipyridamole; DNA; Guinea Pigs; Lymphocyte Activation; Nucleoside Deaminases; Phenylisopropyladenosine; T-Lymphocytes; Theophylline | 1983 |
Selective inhibition of various mitogen responses in human lymphocytes.
Topics: Adenine; Adenosine; B-Lymphocytes; DNA Replication; Humans; Immunosuppressive Agents; Lymphocyte Activation; Mitogens; T-Lymphocytes | 1984 |
Influence of adenosine on the vascular responses to sympathetic nerve stimulation in the canine subcutaneous adipose tissue.
Topics: Adenine; Adenosine; Adipose Tissue; Animals; Body Temperature; Dipyridamole; Dogs; Electric Stimulation; Female; Homeostasis; Inosine; Norepinephrine; Propranolol; Regional Blood Flow; Sympathetic Nervous System; Theophylline; Vascular Resistance; Vasoconstriction | 1983 |
Cytolysis of nucleated cells by complement: inhibition of membrane-transmethylation enhances cell death by C5b-9.
Topics: Adenine; Animals; Ascites; Cell Membrane; Cell Nucleus; Cell Survival; Complement Membrane Attack Complex; Complement Pathway, Alternative; Complement System Proteins; Humans; Methylation; Methyltransferases; Mice; Phosphorylcholine; Rabbits | 1984 |
Adenosine as a mediator of postcontraction hyperemia in dog gracilis muscle.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Animals; Dipyridamole; Dogs; Electric Conductivity; Female; Male; Muscle Contraction; Muscles; Oxygen Consumption; Perfusion | 1984 |
Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cattle; Intestines; Nucleoside Deaminases | 1984 |
Effects of combinations of drugs having different modes of action at the ribonucleotide reductase site on growth of L1210 cells in culture.
Topics: Adenine; Animals; Antineoplastic Agents; Deferoxamine; Deoxyadenosines; Hydroxyurea; Kinetics; Leukemia L1210; Mice; Pyrazoles; Ribonucleotide Reductases | 1982 |
Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants.
Topics: Adenine; Adenosine; Arachidonic Acid; Arachidonic Acids; Chemical Phenomena; Chemistry; Chemoreceptor Cells; Chemotaxis, Leukocyte; Homocysteine; Humans; Kinetics; Lipid Metabolism; Methylation; Monocytes | 1981 |
Differences in the activity of adenosine deaminase and of purine nucleoside phosphorylase and in the sensitivity to deoxypurine nucleosides between subpopulations of mouse thymocytes.
Topics: Adenine; Adenosine Deaminase; Animals; Deoxyadenosines; Deoxyguanosine; DNA; Lectins; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nucleoside Deaminases; Peanut Agglutinin; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Spleen; T-Lymphocytes | 1982 |
Beneficial metabolic effect of nucleoside augmentation on reperfusion injury following cardioplegic arrest.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Heart Arrest, Induced; Myocardium; Phosphocreatine | 1983 |
Uptake and utilization of 5'-methylthioadenosine by cultured baby-hamster kidney cells.
Topics: Adenine; Adenosine; Animals; Cell Division; Cell Line; Cricetinae; Deoxyadenosines; Kidney; Thionucleosides; Tubercidin | 1982 |
Role of adenosine in signal transmission of tubuloglomerular feedback.
Topics: Adenine; Adenosine; Angiotensin II; Animals; Dipyridamole; Dogs; Feedback; Glomerular Filtration Rate; Hydrostatic Pressure; Kidney Glomerulus; Kidney Tubules; Vasoconstriction | 1982 |
Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts.
Topics: Adenine; Adenosine Deaminase; Aminohydrolases; B-Lymphocytes; Cell Line; Humans; Immunologic Deficiency Syndromes; Molecular Weight; Nucleoside Deaminases | 1981 |
Role of adenosine deaminase in the early stages of precursor T cell maturation.
Topics: Adenine; Adenosine Deaminase; Cell Differentiation; Cells, Cultured; Humans; Nucleoside Deaminases; Rosette Formation; T-Lymphocytes | 1981 |
Effect of adenosine deaminase inhibitors on the apparent rate of phosphorylation of deoxyadenosine.
Topics: Adenine; Adenosine Deaminase Inhibitors; Cell Line; Coformycin; Deoxyadenosines; Enzyme Inhibitors; Humans; Leukemia, Lymphoid; Nucleoside Deaminases; Pentostatin; Phosphorylation; Vidarabine | 1981 |
Effect of 2'-deoxycoformycin on erythroid, granulocytic, and T-lymphocyte colony growth.
Topics: Adenine; Adenosine Deaminase Inhibitors; Coformycin; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Erythrocytes; Granulocytes; Growth Inhibitors; Humans; Pentostatin; Phytohemagglutinins; Ribonucleosides; T-Lymphocytes | 1981 |
In vitro effects of adenosine deaminase inhibitors on lymphocyte mitogen responsiveness in the mouse.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cell Survival; Coformycin; Concanavalin A; Female; Horses; Lipopolysaccharides; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mitogens; Nucleoside Deaminases; Pentostatin; Phytohemagglutinins; Spleen; T-Lymphocytes | 1981 |
Serum adenosine deaminase in normals and in a patient with adenosine deaminase deficient-severe combined immunodeficiency.
Topics: Adenine; Adenosine Deaminase; Child; Deoxyadenosines; Female; Humans; Immunologic Deficiency Syndromes; Isoenzymes; Kinetics; Male; Molecular Weight; Nucleoside Deaminases; Spleen | 1981 |
Suppression of human lymphocyte DNA and protein synthesis in vitro by adenosine and eight modified adenine nucleosides in the presence or in the absence of adenosine deaminase inhibitors, 2'-deoxycoformycin (DCF) and erythro-9-(2-hydroxy-3-nonyl) adenine
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Blood Proteins; Coformycin; DNA; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Pentostatin; Phytohemagglutinins | 1982 |
S-Adenosylhomocysteine accumulation and selective cytotoxicity in cultured T- and B-lymphocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; B-Lymphocytes; Cell Division; Cells, Cultured; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Nucleoside Deaminases; S-Adenosylhomocysteine; T-Lymphocytes | 1982 |
Inactivation of liver S-adenosylhomocysteine hydrolase in vitro of rats treated with erythro-9-(2-hydroxynon-3-yl)adenine.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Deoxyadenosines; Enzyme Activation; Female; Hydrolases; Kinetics; Liver; Rats; Rats, Inbred Strains; Temperature | 1982 |
Metabolism of adenosine and 2'-deoxy-adenosine by fetal mouse calvaria in culture.
Topics: Adenine; Adenosine; Animals; Bone and Bones; Culture Media; Deoxyadenosines; Dilazep; Dipyridamole; Hypoxanthine; Hypoxanthines; Inosine; Mice; Organ Culture Techniques | 1982 |
Adenosine deaminase impairment and ribonucleotide reductase activity and levels in HeLa cells.
Topics: Adenine; Adenosine Deaminase; Cell Division; Deoxyadenosines; Deoxyribonucleotides; HeLa Cells; Humans; Nucleoside Deaminases; Ribonucleotide Reductases | 1980 |
Pharmacokinetics of inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine in CBA mice.
Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Erythrocytes; Guanosine Triphosphate; Kinetics; Mice; Mice, Inbred CBA; Nucleoside Deaminases | 1982 |
Effect of chirality in erythro-9-(2-hydroxy-3-nonyl) adenine (EHNA) on adenosine deaminase inhibition.
Topics: Adenine; Adenosine Deaminase Inhibitors; Humans; Immunosuppressive Agents; Kinetics; Nucleoside Deaminases; Stereoisomerism | 1982 |
Improved functional recovery of ischemic myocardium by suppression of adenosine catabolism.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Heart Arrest, Induced; In Vitro Techniques; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains | 1982 |
The influence of adenosine on the no-reflow phenomenon in anoxic and ischaemic hearts.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Coronary Circulation; Coronary Disease; Dilatation, Pathologic; Kinetics; Male; Oxygen; Perfusion; Rats; Rats, Inbred Strains | 1982 |
Effect of 9-beta-D-arabinofuranosyladenine and erythro-9-(2-hydroxy-3-nonyl) adenine on the metabolism of S-adenosylhomocysteine, S-adenosylmethionine, and adenosine in rat liver.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Female; Homocysteine; Hydrolases; Liver; Rats; S-Adenosylhomocysteine; S-Adenosylmethionine; Vidarabine | 1982 |
Effects of the chiral isomers of erythro- and threo-9-(2-hydroxy-3-nonyl)adenine on purine metabolism in sarcoma 180 cells.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Glycine; Guanosine; Hypoxanthines; Inosine; Mice; Nucleoside Deaminases; Purine Nucleosides; Purine Nucleotides; Purines; Sarcoma 180; Stereoisomerism | 1982 |
Role of transmethylation reactions in cellular motility and phagocytosis.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adult; Animals; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Guinea Pigs; Humans; In Vitro Techniques; Lactones; Macrophages; Methylation; Models, Biological; Monocytes; Peptides; Phagocytosis; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Identification of the bioactive enantiomer of erythro-3-(adenin-9-yl)-2-nonanol (EHNA), a semi-tight binding inhibitor of adenosine deaminase.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cattle; Immunosuppressive Agents; Kinetics; Nucleoside Deaminases; Protein Binding; Structure-Activity Relationship | 1981 |
Role of adenosine in adipose tissue circulation.
Topics: Adenine; Adenosine; Adipose Tissue; Animals; Capillary Permeability; Dilazep; Dipyridamole; Dogs; Female; Inosine; Vascular Resistance; Vasodilator Agents | 1981 |
Adenosine deaminase inhibitors. Conversion of a single chiral synthon into erythro- and threo-9-(2-hydroxy-3-nonyl)adenines.
Topics: Adenine; Adenosine Deaminase Inhibitors; Chemical Phenomena; Chemistry; Nucleoside Deaminases | 1981 |
The antilipolytic effect of endogenous and exogenous adenosine in canine adipose tissue in situ.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adipose Tissue; Animals; Dilazep; Dipyridamole; Dogs; Female; Lipolysis | 1981 |
Charcoal-facilitated dialysis.
Topics: 2,6-Dichloroindophenol; Adenine; Adenosine Deaminase Inhibitors; Adsorption; Charcoal; Dialysis | 1980 |
Adenosine metabolism and myocardial preservation. Consequences of adenosine catabolism on myocardial high-energy compounds and tissue blood flow.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Cardiopulmonary Bypass; Dogs; Heart Arrest, Induced; Myocardium; Phosphocreatine; Regional Blood Flow | 1980 |
Inhibitors of the dynein ATPase and ciliary or flagellar motility.
Topics: Acrylamides; Adenine; Aluminum Compounds; Animals; Bacterial Proteins; Cilia; Cnidarian Venoms; Dyneins; Enzyme Inhibitors; Flagella; Fluorides; Male; Movement; Nickel; Sea Urchins; Sperm Motility; Sperm Tail; Sulfonamides; Vanadates | 1995 |
Regulation of extracellular adenosine levels in the striatum of aging rats.
Topics: 2-Amino-5-phosphonovalerate; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Aging; Amino Acids; Animals; Corpus Striatum; Enzyme Inhibitors; Extracellular Space; Male; Microdialysis; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tubercidin | 1995 |
Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic GMP-stimulated phosphodiesterase in isolated cardiac myocytes.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Adenosine Deaminase; Animals; Calcium Channels; Cyclic GMP; Myocardium; Nitric Oxide; Rana esculenta | 1995 |
Adenosine transformation by human red blood cell membranes.
Topics: Adenine; Adenosine; Erythrocyte Membrane; Humans; Piperazines | 1995 |
Deoxynucleoside induces neuronal apoptosis independent of neurotrophic factors.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Apoptosis; Cell Division; Cell Survival; Cells, Cultured; Chick Embryo; Deoxyadenosines; DNA; Nerve Growth Factors; Neurons; Pentostatin; Sympathetic Nervous System | 1995 |
Involvement of adenosine deaminase and adenosine kinase in regulating extracellular adenosine concentration in rat hippocampal slices.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Basal Metabolism; Electric Stimulation; Hippocampus; In Vitro Techniques; Male; Purines; Rats; Tubercidin | 1995 |
Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): is it preconditioning?
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Aorta; Constriction; Dogs; Inosine; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Thioinosine; Ventricular Dysfunction, Left; Ventricular Fibrillation; Ventricular Function, Left | 1995 |
Flexural rigidity of echinoderm sperm flagella.
Topics: Adenine; Animals; Dyneins; Male; Movement; Octoxynol; Pliability; Sea Urchins; Sperm Tail; Trypsin; Vanadates; Viscosity | 1994 |
Endogenous adenosine deaminase does not modulate synaptic transmission in rat hippocampal slices under normoxic or hypoxic conditions.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Electrophysiology; Hippocampus; Hypoxia; Pentostatin; Rats; Rats, Sprague-Dawley; Reference Values; Synaptic Transmission; Theophylline | 1994 |
Adenosine deaminase inhibitors. Synthesis and biological evaluation of putative metabolites of (+)-erythro-9-(2S-hydroxy-3R-nonyl)adenine.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cattle; In Vitro Techniques | 1994 |
Nucleoside trapping during reperfusion prevents ventricular dysfunction, "stunning," in absence of adenosine. Possible separation between ischemic and reperfusion injury.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase Inhibitors; Affinity Labels; Animals; Biological Transport, Active; Dogs; Female; Inosine; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Purinones; Random Allocation; Thioinosine; Ventricular Function, Left | 1994 |
Separation between ischemic and reperfusion injury by site specific entrapment of endogenous adenosine and inosine using NBMPR and EHNA.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Dogs; Female; Heart; Inosine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Thioinosine; Ventricular Function, Left | 1994 |
Release and regulation of endogenous adenosine during hemorrhage.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Blood Pressure; Cats; Chromatography, High Pressure Liquid; Dilazep; Drug Interactions; Female; Hemorrhage; Male | 1994 |
Nucleoside-induced arteriolar constriction: a mast cell-dependent response.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Affinity Labels; Animals; Arterioles; Cricetinae; Dose-Response Relationship, Drug; In Vitro Techniques; Inosine; Male; Mast Cells; Mesocricetus; Methylene Blue; Mouth; Muscle, Smooth, Vascular; p-Methoxy-N-methylphenethylamine; Purinergic P1 Receptor Antagonists; Thioinosine; Vasoconstriction | 1994 |
Augmentation of endogenous adenosine attenuates myocardial 'stunning' independently of coronary flow or hemodynamic effects.
Topics: Adenine; Adenine Nucleotides; Adenosine; Animals; Coronary Circulation; Dogs; Heart; Hemodynamics; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Nucleosides; Thioinosine | 1993 |
Protection of the stunned myocardium. Selective nucleoside transport blocker administered after 20 minutes of ischemia augments recovery of ventricular function.
Topics: Adenine; Adenosine Triphosphate; Affinity Labels; Animals; Chromatography, High Pressure Liquid; Dogs; Drug Therapy, Combination; Female; Inosine; Male; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Thioinosine; Time Factors | 1993 |
Adenosine deaminase inhibitors attenuate ischemic injury and preserve energy balance in isolated guinea pig heart.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Coformycin; Creatine Kinase; Energy Metabolism; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Nucleosides; Phosphates | 1993 |
Adenosine deaminase inhibitor in cardioplegia enhanced function preservation of the hypothermically stored rat heart.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Coronary Circulation; Heart Arrest, Induced; Heart Transplantation; Hemodynamics; Male; Organ Preservation; Rats; Rats, Sprague-Dawley; Time Factors | 1994 |
Accumulation and metabolism of adenallene by murine leukemia L1210 cells.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Biological Transport; Biotransformation; Cytosine; Kinetics; Leukemia L1210; Mice; Temperature; Thymine; Tritium; Tumor Cells, Cultured | 1994 |
Activity-dependent release of endogenous adenosine modulates synaptic responses in the rat hippocampus.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Baclofen; Electric Stimulation; Electrophysiology; Evoked Potentials; Hippocampus; Male; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Purinergic; Synapses; Theophylline | 1993 |
Increases in interstitial adenosine and cerebral blood flow with inhibition of adenosine kinase and adenosine deaminase.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Brain; Cerebrovascular Circulation; Dialysis Solutions; Dose-Response Relationship, Drug; Extracellular Space; Hypoxanthine; Hypoxanthines; Inosine; Male; Rats; Rats, Wistar; Tubercidin | 1993 |
Changes in pial arteriolar diameter and CSF adenosine concentrations during hypoxia.
Topics: Adenine; Adenosine; Animals; Arterioles; Cerebrovascular Circulation; Dipyridamole; Hypoxanthine; Hypoxanthines; Hypoxia; Inosine; Male; Pia Mater; Rats; Rats, Sprague-Dawley; Vasodilation | 1993 |
Adenosine increases lactate release and delays onset of contracture during global low flow ischaemia.
Topics: Adenine; Adenosine; Animals; Glucose; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Rats; Rats, Wistar; Xanthines | 1993 |
Effect of K+ depolarization, tetrodotoxin, and NMDA receptor inhibition on extracellular adenosine levels in rat striatum.
Topics: 2-Amino-5-phosphonovalerate; Adenine; Adenosine; Amino Acids; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dipyridamole; Male; Perfusion; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1993 |
[3H]adenosine transport in synaptoneurosomes of postmortem human brain.
Topics: Adenine; Adenosine; Aged; Biological Transport; Cadaver; Cerebral Cortex; Dilazep; Dipyridamole; Female; Humans; Kinetics; Male; Synaptosomes; Time Factors; Tritium; Tubercidin | 1993 |
Inhibition of adenosine deaminase and nucleoside transport. Utility in a model of homograft cardiac valve preimplantation processing.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Biological Transport, Active; Female; Heart Valves; Organ Preservation; Purine Nucleosides; Swine; Thioinosine; Transplantation, Homologous | 1993 |
Isozyme selective inhibition of cGMP-stimulated cyclic nucleotide phosphodiesterases by erythro-9-(2-hydroxy-3-nonyl) adenine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Calcium; Calmodulin; Chromatography, Ion Exchange; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Humans; Isoenzymes; Male; Myocardium; Swine | 1995 |
Enhancement of the anti-HIV-1 activity of ddAdo by coformycin, EHNA and deaza-EHNA derivatives.
Topics: Adenine; Adenosine Deaminase Inhibitors; Antiviral Agents; Cell Line; Coformycin; Dideoxyadenosine; Drug Evaluation, Preclinical; Drug Synergism; Enzyme Inhibitors; HIV-1; Humans; Virus Replication | 1995 |
Smooth muscle cell-derived adenosine inhibits cell growth.
Topics: Adenine; Adenosine; Animals; Cell Division; Cells, Cultured; Dipyridamole; DNA Replication; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley | 1996 |
Adenosine deaminase inhibition prevents free radical-mediated injury in the postischemic heart.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Coronary Circulation; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Female; Free Radicals; Hydroxyl Radical; Myocardial Ischemia; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxides; Xanthine Oxidase | 1996 |
Erythro-9-(2-hydroxy-3-nonyl)adenine inhibits cyclic-3',5'-guanosine monophosphate-stimulated phosphodiesterase to reverse hypoxic pulmonary vasoconstriction in the perfused rat lung.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Adenosine Deaminase Inhibitors; Animals; Blood Pressure; Cell Hypoxia; Enzyme Inhibitors; Lung; Male; Perfusion; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1996 |
Release of oxygen metabolites from chemoattractant-stimulated neutrophils is inhibited by resting platelets: role of extracellular adenosine and actin polymerization.
Topics: Actin Cytoskeleton; Actins; Adenine; Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Biological Factors; Blood Platelets; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Culture Media, Conditioned; Cytochalasin B; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Purinergic P1 Receptor Antagonists; Reactive Oxygen Species; Receptors, Purinergic P1; Respiratory Burst; Theophylline | 1996 |
Effect of a dynein inhibitor on vasopressin action in toad urinary bladder.
Topics: Adenine; Animals; Dose-Response Relationship, Drug; Dyneins; Enzyme Inhibitors; Osmotic Pressure; Rana esculenta; Time Factors; Urinary Bladder; Vasopressins | 1996 |
Role of adenine nucleotides in the activation of microsomal cholesterol ester hydrolase by fructose or adenosine in rat hepatocytes.
Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; AMP Deaminase; Animals; Cells, Cultured; Enzyme Activation; Female; Fructose; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sterol Esterase | 1996 |
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Antibodies, Monoclonal; Binding, Competitive; CD3 Complex; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Isoenzymes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Phosphodiesterase Inhibitors; Phytohemagglutinins; Pyrrolidinones; Rabbits; Receptors, Antigen, T-Cell; Rolipram; Sensitivity and Specificity; Signal Transduction; Thymus Gland | 1996 |
Characterization of inhibitor-sensitive and -resistant adenosine transporters in cultured human fetal astrocytes.
Topics: Adenine; Adenosine; Affinity Labels; Astrocytes; Biological Transport; Carrier Proteins; Cells, Cultured; Dilazep; Dipyridamole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Humans; Kinetics; Membrane Proteins; Nucleoside Transport Proteins; Thioinosine; Tritium; Tubercidin; Vasodilator Agents | 1996 |
Adenosine uptake and deamination regulate tonic A2a receptor facilitation of evoked [3H]acetylcholine release from the rat motor nerve terminals.
Topics: Acetylcholine; Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Affinity Labels; Animals; Deamination; Diaphragm; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Motor Neurons; Phrenic Nerve; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Purinergic P1; Thioinosine | 1996 |
Effects of quercetin on rat testis aerobic glycolysis.
Topics: Adenine; Adenosine Diphosphate; Aerobiosis; Anaerobiosis; Animals; Ca(2+) Mg(2+)-ATPase; Cytosol; Enzyme Inhibitors; Germ Cells; Glycolysis; In Vitro Techniques; Lactic Acid; Male; Oxygen Consumption; Phosphates; Quercetin; Rats; Rats, Sprague-Dawley; Sertoli Cells; Sodium-Potassium-Exchanging ATPase; Spermatogonia; Testis | 1995 |
Endogenous adenosine increases O2 utilisation efficiency in isoprenaline-stimulated canine myocardium.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adrenergic beta-Agonists; Animals; Dogs; Hypoxia; Isoproterenol; Lactic Acid; Myocardial Contraction; Myocardial Ischemia; Myocardium; Oxygen; Oxygen Consumption; Perfusion; Stimulation, Chemical | 1996 |
AMP degradation in the perfused rat heart during 2-deoxy-D-glucose perfusion and anoxia. Part II: The determination of the degradation pathways using an adenosine deaminase inhibitor.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Monophosphate; Animals; Antimetabolites; Deoxyglucose; Enzyme Inhibitors; Heart; Hemodynamics; Hypoxia; In Vitro Techniques; Inosine Monophosphate; Myocardium; Perfusion; Phosphates; Purine Nucleosides; Rats; Rats, Sprague-Dawley | 1996 |
Involvement of adenosine in retinal ischemia. Studies on the rat.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Calbindin 2; Dyneins; Electroretinography; Enzyme Inhibitors; Eye Proteins; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Ischemia; Phenylisopropyladenosine; Rats; Receptors, Purinergic P1; Reperfusion Injury; Retinal Vessels; S100 Calcium Binding Protein G | 1996 |
Interruption of Escherichia coli heat-stable enterotoxin-induced guanylyl cyclase signaling and associated chloride current in human intestinal cells by 2-chloroadenosine.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Bacterial Toxins; Caco-2 Cells; Chloride Channels; Enterotoxins; Enzyme Inhibitors; Escherichia coli Proteins; Guanylate Cyclase; Humans; Models, Biological; Pentostatin; Purinergic P1 Receptor Agonists; Signal Transduction | 1997 |
Adenosine increases the cAMP content of the rat carotid body in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenine; Adenosine; Animals; Carotid Body; Cyclic AMP; Male; Nerve Tissue Proteins; Perfusion; Phenethylamines; Rats; Rats, Wistar; Receptors, Purinergic P1; Second Messenger Systems | 1996 |
Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Blood Platelets; Cyclic AMP; Dideoxyadenosine; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Humans; Nitroprusside; Platelet Aggregation; Quinazolines | 1997 |
cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Calcium; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 1; Enzyme Inhibitors; Heart Atria; Humans; Ion Transport; Rats | 1997 |
Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries.
Topics: Adenine; Adenosine Deaminase; Animals; Cattle; Drug Design; Enzyme Inhibitors; Furosemide; Humans; Intestines; Ligands; Mass Spectrometry; Methanol; Molecular Weight; Online Systems; Pulsatile Flow; Salicylates; Salicylic Acid; Serum Albumin; Thyroxine; Ultrafiltration; Warfarin | 1997 |
9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine Deaminase Inhibitors; Anticonvulsants; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Isoenzymes; Muscle, Smooth, Vascular; Purines; Structure-Activity Relationship | 1997 |
Modulation by presynaptic adenosine A1 receptors of nicotinic receptor antagonist-induced neuromuscular block in the mouse.
Topics: Adenine; Animals; Enzyme Inhibitors; Hexamethonium; Mice; Mice, Inbred BALB C; Neuromuscular Blockade; Neuromuscular Junction; Nicotinic Antagonists; Purinergic P1 Receptor Antagonists; Receptors, Presynaptic; Receptors, Purinergic P1; Tetany; Vecuronium Bromide; Xanthines | 1997 |
Endogenous adenosine facilitates neurotransmission via A2A adenosine receptors in the rat superior colliculus in vivo.
Topics: Adenine; Adenosine; Animals; Electrophysiology; Enzyme Inhibitors; Purinergic Antagonists; Purines; Rats; Receptors, Purinergic P1; RNA, Messenger; Superior Colliculi; Synaptic Transmission; Xanthines | 1997 |
Neurotoxicity in organotypic hippocampal slices mediated by adenosine analogues and nitric oxide.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Animals, Newborn; Brain Ischemia; Cell Survival; Enzyme Inhibitors; Hippocampus; Neurons; Neurotoxins; Nitric Oxide; Organ Culture Techniques; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Theophylline; Xanthines | 1997 |
Evidence against a major role of adenosine in oxygen-dependent regulation of erythropoietin in rats.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Animals; Antihypertensive Agents; Carbon Monoxide; Dipyridamole; Diuretics; Drug Synergism; Enzyme Inhibitors; Erythropoietin; Gene Expression; Hypoxia; Kidney; Male; Oxygen; Phenethylamines; Phosphodiesterase Inhibitors; Piperazines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger; Theophylline; Vasodilator Agents; Xanthines | 1997 |
Adenosine triphosphate degradation products after oxidative stress and metabolic dysfunction in cultured retinal cells.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Cell Hypoxia; Cells, Cultured; Chick Embryo; Enzyme Inhibitors; Glucose; Hypoxanthine; Inosine; Iodoacetates; Iodoacetic Acid; Ischemia; Kinetics; Oligomycins; Oxidative Stress; Retina; Thioinosine | 1997 |
Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Cattle; Cell Division; Culture Media; Dipyridamole; DNA Replication; Enzyme Inhibitors; Fibroblasts; Heart; Male; Myocardium; Phenethylamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tubercidin; Xanthines | 1997 |
Regulation of adenosine concentration and cytoprotective effects of novel reversible adenosine deaminase inhibitors.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Astrocytoma; Cattle; Cytoprotection; Endothelium, Vascular; Enzyme Inhibitors; Hippocampus; Humans; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 1997 |
Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry.
Topics: Adenine; Adenosine Deaminase Inhibitors; Enzyme Inhibitors; Mass Spectrometry; Ultrafiltration | 1997 |
Cyclic AMP-adenosine pathway induces nitric oxide synthesis in aortic smooth muscle cells.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; Aorta, Thoracic; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Dideoxyadenosine; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Phenethylamines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Signal Transduction; Thionucleotides | 1998 |
Adenosine inhibits growth of human aortic smooth muscle cells via A2B receptors.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adult; Animals; Aorta, Thoracic; Cell Division; Cells, Cultured; Collagen; Dipyridamole; DNA; Humans; Kinetics; Male; Muscle, Smooth, Vascular; Phenethylamines; Purinergic P1 Receptor Antagonists; Rats; Receptor, Adenosine A2B; Receptors, Purinergic P1; Thymidine; Xanthines | 1998 |
Probing the active site of adenosine deaminase by a pH responsive fluorescent competitive inhibitor.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Binding Sites; Binding, Competitive; Catalysis; Cattle; Enzyme Inhibitors; Fluorescence Polarization; Fluorescent Dyes; Hydrogen-Ion Concentration; Intestines; Kinetics; Molecular Structure; Pentostatin; Protein Binding; Spectrometry, Fluorescence; Spectrophotometry | 1998 |
Adenine/ribose supply increases adenosine production and protects ATP pool in adenosine kinase-inhibited cardiac cells.
Topics: Adenine; Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Heart; In Vitro Techniques; Kinetics; Male; Myocardium; Purines; Rats; Rats, Sprague-Dawley; Ribose; Tubercidin; Uridine | 1998 |
Induction of apoptosis by an inhibitor of cAMP-specific PDE in malignant murine carcinoma cells overexpressing PDE activity in comparison to their nonmalignant counterparts.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Carcinoma; Cell Cycle; Cell Division; Cell Size; Cell Transformation, Neoplastic; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; DNA Fragmentation; Isoenzymes; Keratinocytes; Mice; Papilloma; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Pteridines; Pyrrolidinones; Rolipram; Skin Neoplasms; Tumor Cells, Cultured | 1998 |
The levels of adenosine and its metabolites in the guinea pig and rat brain during complete ischemia-in vivo study.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Brain Ischemia; Chromatography, High Pressure Liquid; Dyneins; Enzyme Inhibitors; Guinea Pigs; Hypoxanthine; Inosine; Male; Microwaves; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Tissue Fixation | 1998 |
Dual cardiac microdialysis to assess drug-induced changes in interstitial purine metabolites: adenosine deaminase inhibition versus adenosine kinase inhibition.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Chromatography, High Pressure Liquid; Extracellular Space; Hypoxanthine; Inosine; Male; Microdialysis; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Tubercidin | 1998 |
Role of nucleoside transport and purine release in a rabbit model of myocardial stunning.
Topics: Adenine; Adenine Nucleotides; Adenosine Deaminase Inhibitors; Animals; Carrier Proteins; Dogs; Enzyme Inhibitors; Female; Heart; Hemodynamics; Male; Membrane Proteins; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Stunning; Myocardium; Nucleoside Transport Proteins; Purines; Rabbits; Thioinosine | 1998 |
Differential cardioprotection with selective inhibitors of adenosine metabolism and transport: role of purine release in ischemic and reperfusion injury.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Biological Transport; Carrier Proteins; Dogs; Enzyme Inhibitors; Membrane Proteins; Models, Cardiovascular; Myocardial Ischemia; Myocardial Reperfusion Injury; Nucleoside Transport Proteins; Purines; Thioinosine | 1998 |
Effects of nucleoside transport inhibitors and adenine/ribose supply on ATP concentration and adenosine production in cardiac myocytes.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Biological Transport; Carrier Proteins; Dipyridamole; Enzyme Inhibitors; Membrane Proteins; Myocardium; NAD; Nucleoside Transport Proteins; Rats; Rats, Sprague-Dawley; Ribose; Thioinosine | 1998 |
Absorption and intestinal metabolism of purine dideoxynucleosides and an adenosine deaminase-activated prodrug of 2',3'-dideoxyinosine in the mesenteric vein cannulated rat ileum.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Anti-HIV Agents; Biological Availability; Biological Transport; Catheterization; Didanosine; Enzyme Inhibitors; Ileum; Intestinal Absorption; Male; Mesenteric Veins; Pentostatin; Permeability; Prodrugs; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Rats; Rats, Sprague-Dawley | 1998 |
Optimization of the local inhibition of intestinal adenosine deaminase (ADA) by erythro-9-(2-hydroxy-3-nonyl)adenine: enhanced oral delivery of an ADA-activated prodrug for anti-HIV therapy.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Anti-HIV Agents; Biological Availability; Blood Proteins; Enzyme Inhibitors; Intestinal Absorption; Intestinal Mucosa; Male; Perfusion; Prodrugs; Protein Binding; Purine Nucleosides; Rats; Rats, Sprague-Dawley | 1998 |
Synergistic inhibition of vascular smooth muscle cell migration by phosphodiesterase 3 and phosphodiesterase 4 inhibitors.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Aorta; Becaplermin; Cell Movement; Cells, Cultured; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Synergism; Humans; Kinetics; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Quinolones; Rats; Recombinant Proteins | 1998 |
Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Analysis of Variance; Animals; Caffeine; Central Nervous System Stimulants; Electroshock; Enzyme Inhibitors; Escape Reaction; Fear; Helplessness, Learned; Male; Neural Inhibition; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Restraint, Physical; Stress, Psychological | 1998 |
Role of the cytoskeleton in stimulation of Na+ channels in A6 cells by changes in osmolality.
Topics: Actins; Adenine; Animals; Cell Line; Colchicine; Cytochalasin D; Cytoskeleton; Electric Conductivity; Kidney Tubules, Distal; Microtubules; Nocodazole; Osmolar Concentration; Sodium Channels; Tubulin; Tubulin Modulators; Xenopus laevis | 1998 |
Effects of nucleoside transport inhibitors and adenine/ribose on ATP concentration and adenosine production in cardiac myocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Biological Transport; Cells, Cultured; Dipyridamole; Heart; Myocardium; Rats; Rats, Sprague-Dawley; Thioinosine | 1998 |
Effects of adenine/ribose supply on adenosine production and ATP concentration in adenosine kinase inhibited cardiac cells.
Topics: Adenine; Adenosine; Adenosine Kinase; Adenosine Triphosphate; Animals; Cells, Cultured; Endothelium, Vascular; Heart; Kinetics; Myocardium; Rats; Rats, Sprague-Dawley; Ribose | 1998 |
Effects of adenosine deaminase inhibition on blood pressure in old spontaneously hypertensive rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aging; Animals; Blood Pressure; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Xanthines | 1998 |
Sperm-egg binding in the sea urchin: a high level of intracellular ATP stabilizes sperm attachment to the egg receptor.
Topics: Adenine; Adenosine Triphosphate; Animals; Cell Respiration; Dyneins; Enzyme Inhibitors; Fertilization; Kinetics; Male; Ovum; Peptide Fragments; Protease Inhibitors; Protein Binding; Receptors, Cell Surface; Recombinant Fusion Proteins; Sea Urchins; Sodium Cyanide; Spermatozoa | 1998 |
Modulation of adenosine effects in attenuation of ischemia and reperfusion injury in rat heart.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Enzyme Inhibitors; Heart; Heart Rate; In Vitro Techniques; Isoenzymes; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Organophosphates; Purines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Stroke Volume; Superoxides; Thioinosine; Xanthine Oxidase | 1998 |
Involvement of adenosine in vanadate-stimulated release of lipoprotein lipase activity.
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenylyl Cyclases; Adipose Tissue; Animals; Enzyme Inhibitors; Extracellular Space; In Vitro Techniques; Lipoprotein Lipase; Male; Rats; Rats, Wistar; Stimulation, Chemical; Vanadates | 1998 |
Evidence that IgE receptor stimulation increases adenosine release from rat basophilic leukaemia (RBL-2H3) cells.
Topics: Adenine; Adenosine; Animals; beta-N-Acetylhexosaminidases; Cytoplasmic Granules; Leukemia, Basophilic, Acute; Mast Cells; Purinergic P1 Receptor Agonists; Rats; Receptor, Adenosine A3; Receptors, IgE; Serotonin; Tubercidin; Tumor Cells, Cultured | 1998 |
Metabolic regulation of endogenous adenosine release from single neurons.
Topics: Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Dinucleoside Phosphates; Drug Administration Routes; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Models, Biological; Neurons; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Rats; Theophylline; Tubercidin | 1998 |
Inhibition studies on membrane adenosine deaminase from human placenta.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Cell Membrane; Chromatography, Affinity; Erythrocytes; Female; Humans; Placenta; Pregnancy; Ultracentrifugation | 1998 |
Adenosine inhibits collagen and total protein synthesis in vascular smooth muscle cells.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; Aorta, Abdominal; Cells, Cultured; Collagen; Cyclic AMP; Dipyridamole; Kinetics; Leucine; Male; Muscle, Smooth, Vascular; Proline; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Xanthines | 1999 |
Processing of adenosine receptor agonists in rat and human whole blood.
Topics: Adenine; Adenosine; Adenosine Kinase; Aminohydrolases; Animals; Blood; Deoxyadenosines; Enzyme Inhibitors; Humans; Purinergic P1 Receptor Agonists; Rats; Thioinosine | 1998 |
Regulation of the L-type Ca2+ channel during cardiomyogenesis: switch from NO to adenylyl cyclase-mediated inhibition.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Calcium Channels; Electrophysiology; Enzyme Inhibitors; Heart; Ion Channel Gating; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Stem Cells | 1999 |
Studies on the mechanisms involved in the ATP-induced relaxation in human and rabbit corpus cavernosum.
Topics: Adenine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Enzyme Inhibitors; Humans; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Penis; Pyridoxal Phosphate; Rabbits | 1999 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines | 1999 |
Activation of a cGMP-stimulated cAMP phosphodiesterase by protein kinase C in a liver Golgi-endosomal fraction.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endosomes; Enzyme Activation; Enzyme Inhibitors; Golgi Apparatus; Liver; Male; Naphthalenes; Phosphodiesterase Inhibitors; Protein Kinase C; Quinolones; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors | 1999 |
Involvement of the adenosine neuromodulatory system in the benzodiazepine-induced depression of excitatory synaptic transmissions in rat hippocampal neurons in vitro.
Topics: Adenine; Adenosine; Aminophylline; Animals; Benzodiazepines; Bicuculline; Dentate Gyrus; Dipyridamole; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; Hippocampus; Midazolam; Neurons; Neurotransmitter Agents; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Synaptic Transmission | 1999 |
Quantification of extracellular and intracellular adenosine production: understanding the transmembranous concentration gradient.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Biological Transport; Bradykinin; Coronary Circulation; Cytosol; Depression, Chemical; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Extracellular Space; Guinea Pigs; Heart; Models, Biological; Myocardium; Osmolar Concentration; Oxygen; Oxygen Consumption; Piperazines; Thioinosine; Tubercidin | 1999 |
Propentofylline protects neurons in culture from death triggered by macrophage or microglial secretory products.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Culture Media, Conditioned; Fetus; Hippocampus; Macrophages, Peritoneal; Mice; Microglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Xanthines | 1999 |
Comparative involvement of cyclic nucleotide phosphodiesterases and adenylyl cyclase on adrenocorticotropin-induced increase of cyclic adenosine monophosphate in rat and human glomerulosa cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenylyl Cyclases; Adolescent; Adrenocorticotropic Hormone; Adult; Animals; Cell Membrane; Cells, Cultured; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Rats; Rats, Long-Evans; Zona Glomerulosa | 1999 |
Further evidence for the role of adenosine in hypercapnia/acidosis-evoked coronary flow regulation.
Topics: Acidosis; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Carbon Dioxide; Coronary Circulation; Enzyme Inhibitors; Heart Rate; Hypercapnia; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Time Factors; Tubercidin; Vasodilator Agents | 1999 |
The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.
Topics: Action Potentials; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Anticonvulsants; Brain Chemistry; CHO Cells; Cricetinae; Electrophysiology; Enzyme Inhibitors; Epilepsy; Female; Hippocampus; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; Triazoles | 1999 |
Effects of allopurinol, erythro-9-(2-hydroxy-3-nonyl)adenine and S-(4-nitrobenzyl)-6-thioinosine on the degradation of adenosine 5'-triphosphate in the rat colon muscularis mucosae.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Allopurinol; Animals; Colon; Enzyme Inhibitors; Half-Life; In Vitro Techniques; Intestinal Mucosa; Muscle, Smooth; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Thioinosine | 1999 |
A(2B) receptors mediate antimitogenesis in vascular smooth muscle cells.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Kinase; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticoagulants; Antihypertensive Agents; Aorta, Abdominal; Becaplermin; Cell Division; Dinucleoside Phosphates; Enzyme Inhibitors; Hyperplasia; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Phenethylamines; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Thymidine; Tritium; Tubercidin; Vasodilator Agents; Xanthines | 2000 |
Age-related changes in A(1)-adenosine receptor-mediated bradycardia.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aging; Animals; Bradycardia; Enzyme Inhibitors; Male; Rats; Rats, Wistar; Receptors, Purinergic P1; Tritium | 2000 |
Dominant role of cAMP in regulation of microvessel permeability.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Capillaries; Capillary Permeability; Cyclic AMP; Cyclic GMP; Dideoxyadenosine; Enzyme Inhibitors; Female; Isoquinolines; Male; Mesenteric Veins; Rana pipiens; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Sulfonamides; Venules | 2000 |
Adenosine-mediated killing of cultured epithelial cancer cells.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Apoptosis; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Coformycin; Deoxyadenosines; Dipyridamole; Enzyme Inhibitors; Female; Humans; Kinetics; Ovarian Neoplasms; Pentostatin; Tumor Cells, Cultured | 2000 |
Adenosine and its receptor agonists regulate nitric oxide production and RAW 264.7 macrophages via both receptor binding and its downstream metabolites-inosine.
Topics: Adenine; Adenosine; Bacterial Toxins; Cell Line; Dose-Response Relationship, Drug; Dyneins; Enterotoxins; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Humans; Hypoxanthine; Inosine; Lipopolysaccharides; Macrophages; Nitric Oxide; Nitric Oxide Synthase; Purinergic P1 Receptor Agonists | 2000 |
Adenosine deaminase inhibition attenuates reperfusion low flow and improves graft survival after rat liver transplantation.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Enzyme Inhibitors; Graft Survival; Laser-Doppler Flowmetry; Liver; Liver Circulation; Liver Transplantation; Male; Microcirculation; Nucleosides; Rats; Rats, Inbred Lew; Reperfusion Injury | 2000 |
Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Bicuculline; Convulsants; Disease Models, Animal; Electroencephalography; Enzyme Inhibitors; Excitatory Amino Acid Agonists; GABA Antagonists; Guanosine; Hippocampus; Hypoxanthine; Inosine; Kainic Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Xanthine | 2000 |
Selective transport of adenosine into porcine coronary smooth muscle.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; Biological Transport; Carrier Proteins; Coronary Vessels; Dinoprost; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; In Vitro Techniques; Muscle, Smooth, Vascular; Purinergic P1 Receptor Agonists; Substrate Specificity; Swine; Thioinosine; Vasoconstriction; Vasodilation; Vasodilator Agents | 2000 |
Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R-nonyl)adenine [(+)-EHNA].
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cattle; Enzyme Inhibitors; Intestines; Stereoisomerism; Structure-Activity Relationship | 2000 |
Postischemic cardiac function recovery in the isolated rat heart: effects of adenosine deaminase and nucleoside transport inhibition.
Topics: Adenine; Adenosine Deaminase; Affinity Labels; Animals; Cardioplegic Solutions; Disease Models, Animal; Enzyme Inhibitors; Glucose; In Vitro Techniques; Male; Mannitol; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Procaine; Rats; Rats, Sprague-Dawley; Thioinosine | 2000 |
Renal interstitial adenosine metabolism during ischemia in dogs.
Topics: Adenine; Adenosine; Animals; Antibiotics, Antineoplastic; Dogs; Extracellular Space; Hypoxanthine; Inosine; Ischemia; Kidney; Tubercidin | 2001 |
NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase.
Topics: Adenine; Alkaloids; Aminoquinolines; Animals; Arginine; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Exonucleases; Guanylate Cyclase; Indoles; Kidney Tubules, Distal; Male; Nitric Oxide; Perfusion; Rats; Rats, Sprague-Dawley; Sodium Chloride | 2001 |
Tryptophan environment in adenosine deaminase. I. Enzyme modification with N-bromosuccinimide in the presence of adenosine and EHNA analogues.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Binding Sites; Brain; Bromosuccinimide; Cattle; Enzyme Inhibitors; Kinetics; Protein Conformation; Spleen; Tryptophan | 2001 |
Regulation of cardiac calcium current by NO and cGMP-modulating agents.
Topics: Adenine; Animals; Arginine; Biological Transport; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Cyclic GMP; Cyclic N-Oxides; Enzyme Inhibitors; Exonucleases; Free Radical Scavengers; Guinea Pigs; Imidazoles; In Vitro Techniques; Myocardium; Nitric Oxide; omega-N-Methylarginine; Orchiectomy; Oxadiazoles; Quinoxalines; Receptors, Muscarinic | 2001 |
Activation of presynaptic A1-receptors by endogenous adenosine inhibits acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Cholinergic Fibers; Dipyridamole; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Female; Guinea Pigs; Ileum; Isotope Labeling; Male; Models, Biological; Muscle Contraction; Muscle, Smooth; Receptors, Purinergic P1; Vasodilator Agents; Xanthines | 2001 |
Local response of L-type Ca(2+) current to nitric oxide in frog ventricular myocytes.
Topics: Adenine; Adrenergic beta-Agonists; Animals; Benzoates; Calcium Channels, L-Type; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Electric Conductivity; Enzyme Inhibitors; Imidazoles; Intracellular Membranes; Isoproterenol; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Patch-Clamp Techniques; Phosphoric Diester Hydrolases; Rana esculenta; Tissue Distribution; Ventricular Function | 2001 |
Inhibition of adenosine deaminase attenuates endotoxin-induced release of cytokines in vivo in rats.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Blood Pressure; Caffeine; Catecholamines; Cytokines; Endotoxemia; Endotoxins; Enzyme Inhibitors; Heart; Heart Rate; Male; Propranolol; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Renin; Xanthines | 2001 |
Cardioprotection with adenosine metabolism inhibitors in ischemic-reperfused mouse heart.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Enzyme Inhibitors; Female; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Perfusion; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Theophylline; Tubercidin | 2001 |
Protection from reperfusion injury after cardiac transplantation by inhibition of adenosine metabolism and nucleotide precursor supply.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cardioplegic Solutions; Creatinine; Deoxyadenosines; Enzyme Inhibitors; Heart Transplantation; In Vitro Techniques; Inflammation; Male; Myocardial Reperfusion Injury; Myocardium; Neutrophil Infiltration; Perfusion; Rats; Rats, Sprague-Dawley; Ribose; Treatment Outcome | 2001 |
Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation.
Topics: Adenine; Administration, Topical; Animals; Electric Stimulation; Enzyme Inhibitors; Evoked Potentials, Somatosensory; Injections, Intraperitoneal; Male; Pia Mater; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Theophylline; Triazines; Triazoles; Vasodilation; Vasodilator Agents; Xanthines | 2001 |
Enhanced oral bioavailability of 2'- beta-fluoro-2',3'-dideoxyadenosine (F-ddA) through local inhibition of intestinal adenosine deaminase.
Topics: Adenine; Adenosine Deaminase Inhibitors; Algorithms; Animals; Anti-HIV Agents; Biological Availability; Biological Transport; Chemical Phenomena; Chemistry, Physical; Dideoxyadenosine; Enzyme Inhibitors; Intestinal Absorption; Intestines; Male; Rats; Rats, Sprague-Dawley | 2001 |
NO-cGMP pathway increases the hyperpolarisation-activated current, I(f), and heart rate during adrenergic stimulation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Animals; Calcium Channel Blockers; Cesium; Chlorides; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; Ion Channels; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sinoatrial Node; Stimulation, Chemical | 2001 |
Mechanisms of apoptosis induced by purine nucleosides in astrocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Apoptosis; Astrocytes; Carrier Proteins; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanine; Guanosine; Hypoxanthine; Inosine; Male; Purine Nucleosides; Purinergic P1 Receptor Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A3; Receptors, Purinergic P1; RNA, Messenger | 2002 |
Erythro- and threo-2-hydroxynonyl substituted 2-phenyladenines and 2-phenyl-8-azaadenines: ligands for A1 adenosine receptors and adenosine deaminase.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Aza Compounds; Binding, Competitive; Cattle; Cerebral Cortex; Enzyme Inhibitors; Inhibitory Concentration 50; Ligands; Magnetic Resonance Spectroscopy; Mass Spectrometry; Neostriatum; Radioligand Assay; Receptors, Purinergic P1; Stereoisomerism; Structure-Activity Relationship | 2002 |
Does endogenous or exogenous adenosine facilitate the functional recovery of the cochlea after ischemia?
Topics: Action Potentials; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Cochlea; Enzyme Inhibitors; Guinea Pigs; Ischemia; Recovery of Function; Reperfusion Injury; Time Factors; Vasodilator Agents | 2002 |
Natriuretic peptide receptor-B in adult rat ventricle is predominantly confined to the nonmyocyte population.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Cells, Cultured; Centrifugation, Density Gradient; Cyclic GMP; Fibroblasts; Fluorescent Antibody Technique; Guanylate Cyclase; Heart Ventricles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth; Myocardium; Natriuretic Peptide, C-Type; Octoxynol; Phosphodiesterase Inhibitors; Phosphorylation; Rats; Receptors, Atrial Natriuretic Factor; Tissue Distribution | 2002 |
Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro.
Topics: Adenine; Aged; Aged, 80 and over; Anal Canal; Dipyridamole; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Isoquinolines; Male; Middle Aged; Muscle Relaxation; Muscle, Smooth; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Purinones; Rectum; Rolipram; Tetrahydroisoquinolines; Vinca Alkaloids | 2002 |
Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adult; Blood Platelets; Calcium; Calcium Signaling; Cell Adhesion Molecules; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Humans; Microfilament Proteins; Milrinone; Phosphoproteins; Phosphoric Diester Hydrolases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Processing, Post-Translational; Second Messenger Systems | 2002 |
Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adenosine; Animals; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 4; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Guanylate Cyclase; Hippocampus; N-Methylaspartate; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rolipram | 2002 |
Broad spectrum anticonvulsant activity of BW534U87: possible role of an adenosine-dependent mechanism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amygdala; Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Female; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Seizures; Triazoles; Xanthines | 2002 |
Adenosine A(2a) receptor-mediated inhibition of rod opsin mRNA expression in tiger salamander.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenylyl Cyclases; Ambystoma; Animals; Cells, Cultured; Colforsin; Darkness; Enzyme Inhibitors; Gene Expression Regulation; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Purinergic P1; Retina; Retinal Rod Photoreceptor Cells; RNA, Messenger; Rod Opsins | 2002 |
Effects of an adenosine kinase inhibitor and an adenosine deaminase inhibitor on accumulation of extracellular adenosine by equine articular chondrocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Cartilage, Articular; Chondrocytes; Enzyme Inhibitors; Horses; Lipopolysaccharides; Nitric Oxide; Nitrites; Tubercidin | 2002 |
Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.
Topics: Adenine; Adenosine Deaminase Inhibitors; Administration, Oral; Animals; Area Under Curve; Drug Design; Enzyme Inhibitors; Humans; Hydrogen Bonding; Injections, Intraperitoneal; Mice; Models, Molecular; Pentostatin; Structure-Activity Relationship | 2003 |
Tracer adenosine: a novel myocardial flow marker.
Topics: Adenine; Adenosine; Alprostadil; Animals; Carbon Radioisotopes; Coronary Circulation; Dogs; Isotope Labeling; Microspheres; Myocardial Ischemia; Myocardium; Sensitivity and Specificity; Statistics as Topic; Ventricular Dysfunction, Left | 2003 |
Inhibition of ovarian steroidogenesis by cyclic GMP in a fly.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Alkaloids; Animals; Brain; Calcium Channels; Carbazoles; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diptera; Ecdysteroids; Female; Indoles; Organ Culture Techniques; Ovary; Phosphodiesterase Inhibitors; Quinazolines; Signal Transduction; Stimulation, Chemical | 2003 |
Extracellular purines from cells of seminiferous tubules.
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Animals; Cells, Cultured; Dipyridamole; Enzyme Inhibitors; Extracellular Space; Germ Cells; Kinetics; Male; Paracrine Communication; Phosphodiesterase Inhibitors; Purines; Rats; Rats, Wistar; Receptors, Purinergic; Seminiferous Tubules; Sertoli Cells; Thioinosine | 2003 |
Activation of A(3) receptors by endogenous adenosine inhibits synaptic transmission during hypoxia in rat cortical neurons.
Topics: Adenine; Adenosine; Animals; Cell Hypoxia; Cerebral Cortex; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine; Guanosine Diphosphate; In Vitro Techniques; Male; Neurotransmitter Uptake Inhibitors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyramidal Cells; Rats; Rats, Wistar; Receptor, Adenosine A3; Receptors, Purinergic P1; Synaptic Transmission; Thionucleosides; Thionucleotides; Time Factors | 2003 |
Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium.
Topics: Adenine; Animals; Cyclic AMP; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Female; In Vitro Techniques; Isoenzymes; Male; Milrinone; Myocardial Contraction; Norepinephrine; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Xanthines | 2003 |
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors.
Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Angiogenesis Inhibitors; Animals; Cells, Cultured; DNA-Binding Proteins; Endothelial Growth Factors; Enzyme Inhibitors; Humans; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Lipoproteins; Lymphokines; Macrophages, Peritoneal; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neovascularization, Physiologic; NF-kappa B; Paclitaxel; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2A; Receptors, Cell Surface; Receptors, Purinergic P1; Toll-Like Receptor 2; Toll-Like Receptor 3; Toll-Like Receptor 4; Toll-Like Receptor 5; Toll-Like Receptor 7; Toll-Like Receptor 9; Toll-Like Receptors; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Vasodilator Agents | 2003 |
VEGF-induced HUVEC migration and proliferation are decreased by PDE2 and PDE4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Allantois; Animals; Benzamides; Cell Cycle; Cell Division; Cell Movement; Cells, Cultured; Chick Embryo; Chorion; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 4; Endothelium, Vascular; Enzyme Inhibitors; Humans; Intracellular Membranes; Neovascularization, Physiologic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Umbilical Veins; Vascular Endothelial Growth Factor A | 2003 |
Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Apoptosis; Biological Transport; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Division; Cell Line; Cell Line, Tumor; Coformycin; Dipyridamole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Nucleosides; Oligonucleotide Array Sequence Analysis; Receptor, Adenosine A3; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Uridine Triphosphate | 2003 |
A simple technique for reducing edge effect in cell-based assays.
Topics: Adenine; Androstadienes; Animals; Cell Culture Techniques; Cell Division; CHO Cells; Cricetinae; Cytochalasin B; Gentian Violet; Green Fluorescent Proteins; Humans; Luminescent Proteins; Nocodazole; Receptor, Insulin; Temperature; Wortmannin | 2003 |
Endogenous adenosine modulation of 22Na uptake by rat brain synaptosomes.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Brain; In Vitro Techniques; Rats; Rats, Wistar; Sodium; Sodium Radioisotopes; Synaptosomes; Thioinosine | 2003 |
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Kinetics; Melanocyte-Stimulating Hormones; Melanophores; Melanosomes; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norepinephrine; Papaverine; Perciformes; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rolipram; Signal Transduction; Wortmannin; Xenopus laevis | 2003 |
Phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) by the anti-platelet drug, cilostazol, in platelets.
Topics: Adenine; Adenylyl Cyclases; Blood Proteins; Cell Adhesion Molecules; Cilostazol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Humans; Isoquinolines; Kinetics; Microfilament Proteins; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Sulfonamides; Tetrazoles | 2003 |
Negative functional effects of cyclic GMP are altered by cyclic AMP phosphodiesterases in rabbit cardiac myocytes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Cell Size; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Milrinone; Myocytes, Cardiac; Phosphodiesterase Inhibitors; Rabbits; Thionucleotides | 2003 |
Nitric oxide inhibits arginine-vasotocin-induced increase of water osmotic permeability in frog urinary bladder.
Topics: Adenine; Animals; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Exonucleases; Immunohistochemistry; In Vitro Techniques; Indicators and Reagents; Indoles; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Osmotic Pressure; Permeability; Phosphodiesterase Inhibitors; Rana temporaria; Urinary Bladder; Vasotocin | 2004 |
Regulation of adenosine receptor subtypes during cultivation of human monocytes: role of receptors in preventing lipopolysaccharide-triggered respiratory burst.
Topics: Adenine; Adenosine; Adenosine Deaminase; Base Sequence; Calcium Signaling; Cells, Cultured; Dipyridamole; DNA, Complementary; Humans; In Vitro Techniques; Lipopolysaccharides; Monocytes; Purinergic P1 Receptor Antagonists; Reactive Oxygen Species; Receptors, Purinergic P1; Respiratory Burst; RNA, Messenger | 2004 |
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume | 2004 |
Adenosine deaminase 2 from chicken liver: purification, characterization, and N-terminal amino acid sequence.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amino Acid Sequence; Animals; Chickens; Enzyme Inhibitors; Enzyme Stability; Isoenzymes; Liver; Molecular Sequence Data; Pentostatin; Protein Structure, Quaternary; RNA-Binding Proteins; Sequence Analysis, Protein; Substrate Specificity | 2004 |
Extracellular inosine is modulated by H2O2 and protects sertoli cells against lipoperoxidation and cellular injury.
Topics: Adenine; Adenosine Deaminase Inhibitors; Adenosine Triphosphate; Animals; Cell Survival; Cells, Cultured; Dipyridamole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hydrogen Peroxide; Inosine; Lipid Peroxidation; Male; Niacinamide; Oxidants; Oxidative Stress; Rats; Sertoli Cells; Thioinosine | 2004 |
Positive inotropic effect of the inhibition of cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2) on guinea pig left atria in eu- and hyperthyroidism.
Topics: Adenine; Adenosine; Animals; Cardiotonic Agents; Culture Techniques; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Guinea Pigs; Heart Atria; Hyperthyroidism; Male; Myocardial Contraction; Phosphoric Diester Hydrolases; Thioinosine | 2003 |
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase.
Topics: Adenine; Adenosine; Adenylate Kinase; Aminoimidazole Carboxamide; Apoptosis; Caspase Inhibitors; Dipyridamole; Drug Interactions; Enzyme Activation; Humans; Membrane Potentials; Mitochondria; Receptors, Purinergic P1; Ribonucleotides; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured | 2004 |
Macrophages are a source of extracellular adenosine deaminase-2 during inflammatory responses.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Adenosine Deaminase; Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; Isoenzymes; Macrophages; Male; Monocytes; Peritonitis; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; Sepsis; Transcription Factors | 2004 |
Effects of the sGC stimulator BAY 41-2272 are not mediated by phosphodiesterase 5 inhibition.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Animals; Aorta; Blood Platelets; CHO Cells; Cricetinae; Cricetulus; Cyclic Nucleotide Phosphodiesterases, Type 5; Female; Genitalia; Guanylate Cyclase; Humans; Male; Muscle, Skeletal; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Pyrazoles; Pyridines; Rabbits; Rats; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones | 2004 |
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli.
Topics: Adenine; Animals; Carbachol; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Male; Milrinone; Muscle Contraction; Nitroprusside; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Vinca Alkaloids | 2004 |
Protective effect of adenosine and purine nucleos(t)ides against the death by hydrogen peroxide and glucose deprivation in rat primary astrocytes.
Topics: Adenine; Adenosine; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Benzimidazoles; Carbocyanines; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Hydrogen Peroxide; In Vitro Techniques; L-Lactate Dehydrogenase; Membrane Potentials; Mitochondria; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Sprague-Dawley; Theobromine; Thioinosine; Time Factors; Xanthines | 2005 |
Differential effects of cGMP produced by soluble and particulate guanylyl cyclase on mouse ventricular myocytes.
Topics: Adenine; Animals; Calcium; Carbon Monoxide; Cell Survival; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Heart Ventricles; Male; Mice; Mice, Inbred C57BL; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; S-Nitroso-N-Acetylpenicillamine; Solubility; Thionucleotides | 2005 |
Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress.
Topics: Adenine; Adenosine; Apoptosis; Cells, Cultured; Endothelial Cells; Enzyme Induction; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Humans; Hydrogen Peroxide; Oxidative Stress; Protein Kinase C; Receptors, Purinergic P1; RNA, Messenger; Signal Transduction | 2005 |
The phosphodiesterase 3 inhibitor cilostamide enhances inotropic responses to glucagon but not to dobutamine in rat ventricular myocardium.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Adrenergic beta-Antagonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dobutamine; Dose-Response Relationship, Drug; Drug Synergism; Exonucleases; Female; Glucagon; Heart Ventricles; Imidazoles; In Vitro Techniques; Male; Myocardial Contraction; Phosphodiesterase I; Phosphodiesterase Inhibitors; Purinergic P1 Receptor Antagonists; Quinolones; Rats; Rats, Sprague-Dawley; Ventricular Function; Xanthines | 2005 |
Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Amino Acid Sequence; Binding Sites; Catalytic Domain; Cell-Free System; Crystallography, X-Ray; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphodiesterase Inhibitors; Protein Binding; Protein Biosynthesis; Rolipram; Sequence Alignment; Substrate Specificity; Triticum | 2005 |
Dynein mutations impair autophagic clearance of aggregate-prone proteins.
Topics: Adenine; Adenylyl Imidodiphosphate; Animals; Autophagy; Behavior, Animal; Brain; Chlorocebus aethiops; COS Cells; Crosses, Genetic; Diptera; Dyneins; Humans; Huntingtin Protein; Huntington Disease; Inclusion Bodies; Mice; Mice, Mutant Strains; Mutation; Nerve Tissue Proteins; Nuclear Proteins; PC12 Cells; Proteasome Endopeptidase Complex; Rats; Synucleins | 2005 |
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Carbachol; Cyclic AMP; Cyclic GMP; Gallbladder; Guinea Pigs; Male; Milrinone; Muscle Contraction; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Vinca Alkaloids | 2005 |
Adenosine down-regulates giant depolarizing potentials in the developing rat hippocampus by exerting a negative control on glutamatergic inputs.
Topics: Action Potentials; Adenine; Adenosine; Adenosine Triphosphate; Analgesics; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Hippocampus; In Vitro Techniques; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Wistar; Thioinosine; Xanthines | 2005 |
Reduction in interaction between cGMP and cAMP in dog ventricular myocytes with hypertrophic failure.
Topics: Adenine; Animals; Body Weight; Cardiotonic Agents; Cyclic AMP; Cyclic GMP; Dogs; Drug Interactions; Enzyme Inhibitors; Heart Failure; Hypertrophy, Left Ventricular; Milrinone; Myocardial Contraction; Myocytes, Cardiac; Organ Size; Signal Transduction | 2005 |
Adenosine and deoxyadenosine induces apoptosis in oestrogen receptor-positive and -negative human breast cancer cells via the intrinsic pathway.
Topics: Adenine; Adenosine; Apoptosis; Breast Neoplasms; Caspase 3; Caspase 9; Caspases; Cell Line, Tumor; Cell Proliferation; Deoxyadenosines; Dose-Response Relationship, Drug; Humans; Receptors, Estrogen; Thioinosine; Time Factors | 2005 |
A new chemical tool for exploring the physiological function of the PDE2 isozyme.
Topics: Adenine; Administration, Oral; Animals; Cyclic Nucleotide Phosphodiesterases, Type 2; Drug Evaluation, Preclinical; Indoles; Isoenzymes; Molecular Structure; Oxindoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Solubility; Structure-Activity Relationship | 2006 |
Extracellular inosine participates in tumor necrosis factor-alpha induced nitric oxide production in cultured Sertoli cells.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cells, Cultured; Extracellular Space; Inosine; Male; Nitric Oxide; Rats; Rats, Wistar; Sertoli Cells; Tumor Necrosis Factor-alpha | 2006 |
Assay of adenosine deaminase isoforms by HPLC.
Topics: Adenine; Adenosine; Adenosine Deaminase; Benzyl Compounds; Chromatography, High Pressure Liquid; Hypoxanthine; Inosine; Isoenzymes | 2006 |
Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
Topics: Adenine; Animals; Calcium; Cells, Cultured; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Enzyme Activation; Isoproterenol; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide; Norepinephrine; Phosphoric Diester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction | 2006 |
The role of adenosine in chondrocyte death in murine osteoarthritis and in a murine chondrocyte cell line.
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Apoptosis; Cartilage, Articular; Cell Death; Cell Line; Chondrocytes; DNA Fragmentation; Enzyme Inhibitors; Homocysteine; Male; Mice; Mice, Inbred Strains; Osteoarthritis; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; Tubercidin | 2006 |
Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells.
Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Aorta; Cattle; Endothelium, Vascular; Enzyme Induction; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Oxygen; Purinergic P1 Receptor Antagonists; Reactive Oxygen Species; Xanthine Oxidase | 2006 |
Fine-tuning modulation of myenteric motoneurons by endogenous adenosine: on the role of secreted adenosine deaminase.
Topics: Acetylcholine; Adenine; Adenine Nucleotides; Adenosine; Adenosine Deaminase; Analysis of Variance; Animals; Calcium; Cholinergic Antagonists; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Motor Neurons; Myenteric Plexus; Neural Inhibition; Purinergic Antagonists; Purines; Rats; Rats, Wistar; Tritium | 2006 |
Solid-phase enzyme activity assay utilizing an entrapped fluorescence-signaling DNA aptamer.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aptamers, Nucleotide; Biological Assay; Fluorescence; Spectrometry, Fluorescence; Time Factors | 2006 |
Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cell Compartmentation; Cell Membrane; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 5; Cyclic Nucleotide-Gated Cation Channels; Heart Ventricles; Humans; Ion Channel Gating; Ion Channels; Isoenzymes; Male; Myocytes, Cardiac; Natriuretic Peptide, Brain; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Rats; Rats, Wistar; Recombinant Fusion Proteins; Sarcolemma; Second Messenger Systems; Sildenafil Citrate; Solubility; Sulfones | 2006 |
Modulation of ischaemic contracture in mouse hearts: a 'supraphysiological' response to adenosine.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Animals; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocardial Reperfusion Injury; Receptor, Adenosine A1; Theophylline; Time Factors; Ventricular Function, Left; Ventricular Pressure; Xanthines | 2007 |
Anandamide inhibits endothelin-1 production by human cultured endothelial cells: a new vascular action of this endocannabinoid.
Topics: Adenine; Adenosine; Arachidonic Acids; Cannabinoid Receptor Modulators; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Endothelial Cells; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Humans; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Xanthines | 2007 |
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Rats; Ribonucleosides | 2007 |
Inhibition of adenosine deaminase attenuates inflammation in experimental colitis.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Benzenesulfonates; Body Weight; Colitis; Colon; Cyclooxygenase 2; Dexamethasone; Eating; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Interleukin-6; Intestinal Mucosa; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Organ Size; Peroxidase; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Spleen; Tumor Necrosis Factor-alpha | 2007 |
Conformational change of adenosine deaminase during ligand-exchange in a crystal.
Topics: Adenine; Adenosine Deaminase; Animals; Binding Sites; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Ligands; Protein Conformation; Tubercidin; Water | 2008 |
Kinetic characterization of adenosine deaminase activity in zebrafish (Danio rerio) brain.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Brain; Cattle; Deamination; Hydrogen-Ion Concentration; Kinetics; Membranes; Metals; Solubility; Substrate Specificity; Temperature; Time Factors; Zebrafish | 2008 |
Adenosine as an endogenous regulating factor of hippocampal sharp waves.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Membrane Potentials; Mice; Mice, Inbred C57BL; Microelectrodes; Nucleoside Transport Proteins; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate; Theophylline; Xanthines | 2009 |
The adenosine deaminase inhibitor erythro-9-[2-hydroxyl-3-nonyl]-adenine decreases intestinal permeability and protects against experimental sepsis: a prospective, randomised laboratory investigation.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Female; Intestinal Absorption; Lipopolysaccharides; Male; Mice; Permeability; Prospective Studies; Rats; Rats, Wistar; Sepsis | 2008 |
Shared requirement for dynein function and intact microtubule cytoskeleton for normal surface expression of cardiac potassium channels.
Topics: Adenine; Antineoplastic Agents; Biological Transport, Active; Biotinylation; Cell Line; Chloride Channels; CLC-2 Chloride Channels; Cytoskeleton; Dyneins; Electrophysiology; Endopeptidase K; Heart; Heart Ventricles; Humans; Microtubules; Myocardium; Myocytes, Cardiac; NF-kappa B p50 Subunit; Nocodazole; Plasmids; Potassium Channels; Receptors, Cell Surface; Transfection | 2009 |
Dynein motor contributes to stress granule dynamics in primary neurons.
Topics: Adenine; Adenylyl Imidodiphosphate; Animals; Animals, Newborn; Antigens, Surface; Arsenites; Carrier Proteins; Cell Count; Cells, Cultured; Cysteine; Cytoplasmic Granules; Dose-Response Relationship, Drug; Drosophila Proteins; Dyneins; ELAV Proteins; ELAV-Like Protein 1; Endopeptidase K; Enzyme Inhibitors; Indoles; Methionine; Motor Neurons; Nonlinear Dynamics; Protein Subunits; Protein Transport; Rats; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Spinal Cord; Stress, Physiological; Sulfur Isotopes; Teratogens; Time Factors | 2009 |
The effects of dynein inhibition on the autophagic pathway in glioma cells.
Topics: Adenine; Amino Acids; Autophagy; Cell Line, Tumor; Dynactin Complex; Dyneins; Enzyme Inhibitors; Glioma; Humans; Lysosomes; Microscopy, Confocal; Microtubule-Associated Proteins; Microtubules; Nocodazole; Tubulin Modulators; Vinblastine | 2010 |
Purinergic modulation in the development of the rat uncrossed retinotectal pathway.
Topics: Adenine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine Deaminase Inhibitors; Adenosine-5'-(N-ethylcarboxamide); Animals; Animals, Newborn; Central Nervous System Agents; Cyclic AMP; Enzyme Inhibitors; Horseradish Peroxidase; Neuronal Tract-Tracers; Rats; Rats, Inbred Strains; Receptor, Adenosine A1; Receptor, Adenosine A2A; Retina; Superior Colliculi; Visual Pathways | 2009 |
A novel mouse model for sudden unexpected death in epilepsy (SUDEP): role of impaired adenosine clearance.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Caffeine; Cause of Death; Death, Sudden; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Kainic Acid; Mice; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Risk Factors; Seizures; Survival Analysis; Tubercidin | 2010 |
Caspase-4 activation in association with decreased adenosine deaminase activity may be a factor for gastric ulcer.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adult; Aged; Animals; Apoptosis; Caspase 3; Caspases, Initiator; Cell Line, Tumor; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Female; Gastric Mucosa; Humans; Intestinal Mucosa; Male; Middle Aged; Osmolar Concentration; Rats; Stomach; Stomach Ulcer | 2010 |
Influence of an adenosine deaminase inhibitor, erythro-9-(2-hydroxy-3-nonyl) adenine hydrochloride, on 5-HT2CR mRNA editing in primary cultured cortical cells.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Cell Culture Techniques; Cells, Cultured; Cerebral Cortex; Rats; Receptor, Serotonin, 5-HT2C; Receptors, Glutamate; RNA Precursors; RNA Processing, Post-Transcriptional; Serotonin 5-HT2 Receptor Antagonists | 2010 |
Strategy to fabricate an electrochemical aptasensor: application to the assay of adenosine deaminase activity.
Topics: Adenine; Adenosine Deaminase; Aptamers, Nucleotide; Biosensing Techniques; Electrochemical Techniques; Electrodes; Enzyme Inhibitors | 2010 |
Mechanisms regulating the nuclear translocation of p38 MAP kinase.
Topics: Active Transport, Cell Nucleus; Adenine; Animals; Arsenites; Blotting, Western; Cell Nucleus; Cells, Cultured; Dyneins; Embryo, Mammalian; Fibroblasts; Green Fluorescent Proteins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubules; Mutation; NIH 3T3 Cells; Nocodazole; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Transfection; Tubulin Modulators | 2010 |
Rapid determination of adenosine deaminase kinetics using fast-scan cyclic voltammetry.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Caffeine; Cattle; Electric Conductivity; Electrochemistry; Enzyme Assays; Kinetics; Oxidation-Reduction; Pentostatin; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Silver; Time Factors | 2010 |
The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Blotting, Western; Body Weight; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Male; Organ Size; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Adenosine A3 | 2010 |
Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells.
Topics: Adenine; Adenosine Deaminase Inhibitors; Antigens, Differentiation; Cell Culture Techniques; Cell Differentiation; Cell Line; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation, Developmental; Homeodomain Proteins; Humans; Hydrophobic and Hydrophilic Interactions; Nanog Homeobox Protein; Neurons; Octamer Transcription Factor-3; Phosphodiesterase Inhibitors; Pluripotent Stem Cells; Second Messenger Systems; Stage-Specific Embryonic Antigens; Structure-Activity Relationship; Time Factors | 2010 |
Inhibition of ATP release from erythrocytes: a role for EPACs and PKC.
Topics: Adenine; Adenosine Triphosphate; Cilostazol; Colforsin; Cyclic AMP; Enzyme Activation; Erythrocytes; Guanine Nucleotide Exchange Factors; Humans; Iloprost; In Vitro Techniques; Isoproterenol; Models, Biological; Naphthalenes; Phosphodiesterase Inhibitors; Protein Kinase C; Rolipram; Signal Transduction; Tetradecanoylphorbol Acetate; Tetrazoles; Thionucleotides | 2011 |
Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance.
Topics: Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Bronchi; Cattle; Cilia; Epithelial Cells; Female; In Vitro Techniques; Isoproterenol; Mice; Mice, Knockout; Movement; Procaterol; Protein Isoforms; Purinergic Agents; Receptors, Purinergic P1; Trachea | 2011 |
Distinctive immunoregulatory effects of adenosine on T cells of older humans.
Topics: Adenine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adult; Age Factors; Aged; Aged, 80 and over; Antigens, CD; Apyrase; CD28 Antigens; Cells, Cultured; Chemotaxis; Cytokines; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Male; Middle Aged; Phenethylamines; Pyrimidines; T-Lymphocytes; Triazoles; Young Adult | 2012 |
Adenosine-mediated cardiovascular toxicity in amitriptyline-poisoned rats.
Topics: Adenine; Adenosine; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arterial Pressure; Glucose; Heart Rate; Infusions, Intravenous; Long QT Syndrome; Male; Rats; Rats, Wistar; Thioinosine; Time Factors | 2012 |
Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function.
Topics: Adenine; Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Transport; Brain Chemistry; Cerebral Cortex; Cognition Disorders; Dynactin Complex; Dyneins; Endocytosis; Enzyme Inhibitors; Macaca fascicularis; Microtubule-Associated Proteins; Microtubules; Neurofilament Proteins; Neurons; rab GTP-Binding Proteins; Receptor, trkB; Synaptic Vesicles | 2012 |
On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor.
Topics: Adenine; Adenosine Deaminase Inhibitors; Animals; Chromatography, High Pressure Liquid; Constriction; Disease Models, Animal; Dogs; Ischemic Preconditioning; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Nucleoside Transport Proteins; Receptor, Adenosine A1; Theophylline; Thioinosine; Xanthines | 2012 |
Reduced adenosine release from the aged mammalian heart.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Adrenergic Antagonists; Aging; Animals; Heart; Hydrolases; Male; Myocardial Contraction; Perfusion; Rats; Rats, Inbred F344; S-Adenosylhomocysteine; Sodium Chloride; Tubercidin | 2012 |
The adenosine deaminases of Plasmodium vivax and Plasmodium falciparum exhibit surprising differences in ligand specificity.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Computer Simulation; Drug Design; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmodium falciparum; Plasmodium vivax; Protein Binding; Protozoan Proteins; Species Specificity; Structural Homology, Protein | 2012 |
Measurement of deoxyinosine adduct: Can it be a reliable tool to assess oxidative or nitrosative DNA damage?
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Cattle; Chromatography, Liquid; Cyclic N-Oxides; DNA; DNA Adducts; DNA Damage; Inosine; Liver; Male; Rats; Rats, Inbred F344; Tandem Mass Spectrometry | 2012 |
High-intensity swimming exercise reduces neuropathic pain in an animal model of complex regional pain syndrome type I: evidence for a role of the adenosinergic system.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Adenosine Deaminase Inhibitors; Animals; Caffeine; Exercise Therapy; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Neurons; Reflex Sympathetic Dystrophy; Swimming; Triazines; Triazoles; Xanthines | 2013 |
Characterization of phosphodiesterase 2A in human malignant melanoma PMP cells.
Topics: Adenine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclin A; DNA; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Mouth Neoplasms; Mutation | 2013 |
Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery befor
Topics: Adenine; Adenosine Triphosphate; Animals; Cold Ischemia; Disease Models, Animal; Dogs; Equilibrative Nucleoside Transporter 1; Female; Heart Arrest, Induced; Hypothermia, Induced; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Myocardium; Recovery of Function; Thioinosine; Time Factors; Ventricular Function, Left; Warm Ischemia | 2013 |
Regulation of autophagic flux by dynein-mediated autophagosomes trafficking in mouse coronary arterial myocytes.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Calcium; Coronary Vessels; Dynactin Complex; Dyneins; Heat-Shock Proteins; Ketocholesterols; Lysosomes; Membrane Fusion; Mice; Microscopy, Confocal; Microtubule-Associated Proteins; Muscle Cells; NADP; Phagosomes; Sequestosome-1 Protein | 2013 |
Role of the A(2B) receptor-adenosine deaminase complex in colonic dysmotility associated with bowel inflammation in rats.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Benzenesulfonates; Colitis; Colon; Gastrointestinal Motility; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peroxidase; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Tumor Necrosis Factor-alpha | 2014 |
Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Humans; Melanoma; RNA Interference; RNA, Small Interfering; Rolipram | 2014 |
Repetitive systemic morphine alters activity-dependent plasticity of Schaffer-collateral-CA1 pyramidal cell synapses: involvement of adenosine A1 receptors and adenosine deaminase.
Topics: Adenine; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Animals; Biophysical Phenomena; CA1 Region, Hippocampal; Drug Administration Schedule; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Male; Morphine; Narcotics; Nerve Fibers; Nerve Net; Neuronal Plasticity; Rats; Rats, Wistar; Receptor, Adenosine A1; Xanthines | 2014 |
PDE2 is a novel target for attenuating tumor formation in a mouse model of UVB-induced skin carcinogenesis.
Topics: Adenine; Animals; Apoptosis; Caffeine; Carcinogenesis; Cyclic Nucleotide Phosphodiesterases, Type 2; Disease Models, Animal; Epidermis; Female; Mice; Molecular Targeted Therapy; Nucleotides, Cyclic; Phosphodiesterase 4 Inhibitors; Skin Neoplasms; Ultraviolet Rays | 2014 |
PDE2 activity differs in right and left rat ventricular myocardium and differentially regulates β2 adrenoceptor-mediated effects.
Topics: Adenine; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Heart Ventricles; Imidazoles; In Vitro Techniques; Myocardial Contraction; Myocardium; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; RNA, Messenger | 2015 |
Modulation of adenosine signaling prevents scopolamine-induced cognitive impairment in zebrafish.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Animals; Avoidance Learning; Cognition Disorders; Dipyridamole; Disease Models, Animal; Motor Activity; Muscarinic Antagonists; Nucleoside Transport Proteins; Purinergic P1 Receptor Antagonists; Scopolamine; Signal Transduction; Social Behavior; Zebrafish | 2015 |
Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Humans; Mesothelioma; Mice; Mice, Nude; Morpholines; Pleural Neoplasms; Pyrimidines; RNA Interference; RNA, Small Interfering; Transplantation, Heterologous | 2015 |
Habituation-Like Decrease of Acetylcholine-Induced Inward Current in Helix Command Neurons: Role of Microtubule Motor Proteins.
Topics: Acetylcholine; Adenine; Animals; Cell Membrane; Dyneins; Habituation, Psychophysiologic; Helix, Snails; Ion Channel Gating; Kinesins; Microtubule Proteins; Molecular Motor Proteins; Neurons; Receptors, Cholinergic | 2015 |
Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult.
Topics: Acetylglucosaminidase; Adenine; Adenosine Deaminase; Adenosine Kinase; Animals; Animals, Newborn; Blotting, Western; Brain; Cerebral Cortex; Hypoxia-Ischemia, Brain; Inflammation; Isoenzymes; Male; Peroxidase; Purines; Rats, Wistar; Receptor, Adenosine A1 | 2015 |
An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat.
Topics: Adenine; Adenosine; Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Adenosine Kinase; Analgesics; Animals; Animals, Newborn; Enzyme Inhibitors; Membrane Potentials; Morpholines; Motor Neurons; Neural Pathways; Nociceptive Pain; Pyrimidines; Reflex; Spinal Cord; Tissue Culture Techniques; Xanthines | 2015 |
The ABCC4 membrane transporter modulates platelet aggregation.
Topics: Adenine; Animals; Blood Platelets; Cyclic AMP; Humans; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Platelet Aggregation; Thrombosis | 2015 |
Inhibition of adenosine metabolism induces changes in post-ictal depression, respiration, and mortality in genetically epilepsy prone rats.
Topics: Adenine; Adenosine; Animals; Blood Gas Analysis; Brugada Syndrome; Disease Models, Animal; Enzyme Inhibitors; Epilepsy; Female; Genetic Predisposition to Disease; Incidence; Male; Oxygen; Rats; Respiration; Respiration Disorders; Seizures; Sex Characteristics; Tubercidin | 2016 |
Hibernation reduces cellular damage caused by warm hepatic ischemia-reperfusion in ground squirrels.
Topics: Adenine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Female; Heme Oxygenase-1; Hibernation; Inosine; Interleukin-6; Liver; Male; Reperfusion Injury; Sciuridae | 2017 |
Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors.
Topics: Adenine; Adenosine Deaminase Inhibitors; Catalytic Domain; Enzyme Activation; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2017 |
Role of atrial natriuretic peptide in controlling diabetic nephropathy in rats.
Topics: Adenine; Animals; Atrial Natriuretic Factor; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Male; Nitrates; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Streptozocin | 2018 |
Increased dNTP pools rescue mtDNA depletion in human POLG-deficient fibroblasts.
Topics: Adenine; Adult; Catalytic Domain; Cells, Cultured; Deoxyribonucleotides; DNA Polymerase gamma; DNA Replication; DNA, Mitochondrial; Ethidium; Female; Fibroblasts; Genotype; Humans; Male; Mitochondria, Muscle; Models, Molecular; Mutation, Missense; Phenotype; Point Mutation; Protein Conformation; Real-Time Polymerase Chain Reaction; Sequence Deletion | 2019 |
Characterization of total adenosine deaminase activity (ADA) and its isoenzymes in saliva and serum in health and inflammatory conditions in four different species: an analytical and clinical validation pilot study.
Topics: Adenine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Automation; Biomarkers; Cattle; Clinical Enzyme Tests; Dogs; Horses; Inflammation; Isoenzymes; Saliva; Swine | 2020 |
Inhibition of ecto-5'-nucleotidase and adenosine deaminase is able to reverse long-term behavioural effects of early ethanol exposure in zebrafish (Danio rerio).
Topics: 5'-Nucleotidase; Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Animals; Antisocial Personality Disorder; Behavior, Animal; Disease Models, Animal; Ethanol; Female; Humans; Pregnancy; Prenatal Exposure Delayed Effects; Social Interaction; Zebrafish | 2020 |
Phosphodiesterases 2, 3 and 4 can decrease cardiac effects of H
Topics: Adenine; Animals; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Female; Heart Atria; Heart Rate; Histamine; Humans; Male; Mice; Mice, Transgenic; Phosphodiesterase Inhibitors; Quinolones; Receptors, Histamine H2; Rolipram | 2021 |