adenine has been researched along with 9-((2-phosphonylmethoxy)ethyl)guanine in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (52.63) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 4 (21.05) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holý, A; Merta, A; Stĕtina, R; Votruba, I | 1 |
| Balzarini, J; Casara, P; De Clercq, E; Egberink, H; Hartmann, K; Navé, JF; Pannecouque, C; Vahlenkamp, T; Witvrouw, M | 1 |
| Connelly, MC; Fridland, A; Lee, SH; Pisarev, VM | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 2 |
| Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I | 1 |
| Eckschlager, T; Franek, F; Holy, A; Votruba, I | 1 |
| Compton, ML; Paborsky, LR; Toole, JJ | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L; Segers, C; Verbeken, E; Waer, M | 1 |
| Downey, KM; Kramata, P | 1 |
| Holý, A; Horská, K; Krejcová, R; Votruba, I | 1 |
| Holý, A; Schinkmanová, M; Votruba, I | 1 |
| Andrei, G; De Clercq, E; Holý, A; Horejsí, K; Pohl, R; Snoeck, R | 1 |
| Holý, A; Otová, B; Votruba, I | 1 |
| Holy, A; Hrdy, J; Otová, B; Votruba, I | 1 |
| Aldern, KA; Beadle, JR; Hostetler, KY; Trahan, J; Valiaeva, N | 1 |
| Cvilink, V; Hájek, M; Holý, A; Mertlíková-Kaiserová, H; Votruba, I | 1 |
| Holý, A; Mertlíková-Kaiserová, H; Procházková, E; Rumlová, M; Tloušťová, E; Votruba, I | 1 |
| Holy, A; Mertlíková-Kaiserová, H; Nejedlá, M; Votruba, I | 1 |
1 review(s) available for adenine and 9-((2-phosphonylmethoxy)ethyl)guanine
| Article | Year |
|---|---|
[Acyclic nucleoside phosphonates as potential antineoplastic agents].
Topics: Adenine; Alanine; Animals; Antineoplastic Agents; Cell Line, Tumor; Guanine; Humans; Lymphoma, Non-Hodgkin; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines | 2008 |
18 other study(ies) available for adenine and 9-((2-phosphonylmethoxy)ethyl)guanine
| Article | Year |
|---|---|
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine | 1993 |
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NM
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Fibroblasts; Guanine; Humans; Mice; Mice, Inbred C3H; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Sarcoma Viruses, Murine; Tenofovir | 1997 |
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
Topics: Adenine; Antineoplastic Agents; Cell Line; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Simian virus 40; Tenofovir | 1997 |
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Genotoxicity of purine acyclic nucleotide analogs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine | 1997 |
Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Deamination; Dideoxynucleosides; Guanine; Humans; Organophosphorus Compounds; Prodrugs; Rats; Tumor Cells, Cultured | 1999 |
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
Topics: Adenine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Antineoplastic Agents; Cell Cycle; Cell Differentiation; Cell Division; Deoxyadenine Nucleotides; Drug Interactions; Drug Screening Assays, Antitumor; Erythrocytes; Guanine; Humans; K562 Cells; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Pentostatin; Prodrugs; Rats; Tumor Cells, Cultured | 1999 |
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antineoplastic Agents; Choriocarcinoma; Female; Guanine; Male; Organophosphonates; Organophosphorus Compounds; Pregnancy; Prodrugs; Rats; Tumor Cells, Cultured; Uterine Neoplasms | 1999 |
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
Topics: Adenine; Animals; Antineoplastic Agents; Guanine; Guanosine Monophosphate; Guanylate Kinases; Isoenzymes; Kinetics; Nucleoside-Phosphate Kinase; Organophosphorus Compounds; Phosphorylation; Substrate Specificity; Swine | 2000 |
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
Topics: Adenine; Aminohydrolases; Animals; Catalysis; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Guanine; In Vitro Techniques; Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley | 2006 |
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
Topics: Adenine; Antiviral Agents; Cell Proliferation; Cytomegalovirus; Guanine; Herpesvirus 3, Human; Humans; Organophosphorus Compounds; Structure-Activity Relationship | 2006 |
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
Topics: Adenine; Animals; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Guanine; Lymphoma, T-Cell; Male; Neovascularization, Pathologic; Organophosphorus Compounds; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2009 |
Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Female; Guanine; HeLa Cells; Humans; Mice; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2010 |
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
Topics: Adenine; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; In Situ Hybridization, Fluorescence; Organophosphorus Compounds; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA; Telomerase; Telomere; Time Factors | 2010 |
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
Topics: Adenine; Adenylate Kinase; Amino Acid Sequence; Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Guanine; Guanylate Kinases; Humans; Molecular Sequence Data; Organophosphorus Compounds; Phosphorylation; Point Mutation | 2011 |
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
Topics: Adenine; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Guanine; HL-60 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Organophosphorus Compounds; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2012 |