adenine and 9-((2-phosphonylmethoxy)ethyl)guanine

adenine has been researched along with 9-((2-phosphonylmethoxy)ethyl)guanine in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (52.63)18.2507
2000's5 (26.32)29.6817
2010's4 (21.05)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Holý, A; Merta, A; Stĕtina, R; Votruba, I1
Balzarini, J; Casara, P; De Clercq, E; Egberink, H; Hartmann, K; Navé, JF; Pannecouque, C; Vahlenkamp, T; Witvrouw, M1
Connelly, MC; Fridland, A; Lee, SH; Pisarev, VM1
Balzarini, J; De Clercq, E; Hatse, S; Naesens, L2
Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I1
Eckschlager, T; Franek, F; Holy, A; Votruba, I1
Compton, ML; Paborsky, LR; Toole, JJ1
Balzarini, J; De Clercq, E; Hatse, S; Naesens, L; Segers, C; Verbeken, E; Waer, M1
Downey, KM; Kramata, P1
Holý, A; Horská, K; Krejcová, R; Votruba, I1
Holý, A; Schinkmanová, M; Votruba, I1
Andrei, G; De Clercq, E; Holý, A; Horejsí, K; Pohl, R; Snoeck, R1
Holý, A; Otová, B; Votruba, I1
Holy, A; Hrdy, J; Otová, B; Votruba, I1
Aldern, KA; Beadle, JR; Hostetler, KY; Trahan, J; Valiaeva, N1
Cvilink, V; Hájek, M; Holý, A; Mertlíková-Kaiserová, H; Votruba, I1
Holý, A; Mertlíková-Kaiserová, H; Procházková, E; Rumlová, M; Tloušťová, E; Votruba, I1
Holy, A; Mertlíková-Kaiserová, H; Nejedlá, M; Votruba, I1

Reviews

1 review(s) available for adenine and 9-((2-phosphonylmethoxy)ethyl)guanine

ArticleYear
[Acyclic nucleoside phosphonates as potential antineoplastic agents].
    Casopis lekaru ceskych, 2008, Volume: 147, Issue:9

    Topics: Adenine; Alanine; Animals; Antineoplastic Agents; Cell Line, Tumor; Guanine; Humans; Lymphoma, Non-Hodgkin; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines

2008

Other Studies

18 other study(ies) available for adenine and 9-((2-phosphonylmethoxy)ethyl)guanine

ArticleYear
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
    Neoplasma, 1993, Volume: 40, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine

1993
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NM
    Antimicrobial agents and chemotherapy, 1997, Volume: 41, Issue:3

    Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Fibroblasts; Guanine; Humans; Mice; Mice, Inbred C3H; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Sarcoma Viruses, Murine; Tenofovir

1997
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
    Molecular pharmacology, 1997, Volume: 52, Issue:1

    Topics: Adenine; Antineoplastic Agents; Cell Line; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Simian virus 40; Tenofovir

1997
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
    Biochimica et biophysica acta, 1998, Mar-12, Volume: 1402, Issue:1

    Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured

1998
Genotoxicity of purine acyclic nucleotide analogs.
    Folia biologica, 1997, Volume: 43, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine

1997
Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
    International journal of oncology, 1999, Volume: 14, Issue:4

    Topics: Adenine; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; DNA, Neoplasm; Drug Screening Assays, Antitumor; Guanine; HL-60 Cells; Humans; Leukemia, Myeloid; Organophosphorus Compounds; Tumor Cells, Cultured

1999
9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).
    Biochemical pharmacology, 1999, Aug-15, Volume: 58, Issue:4

    Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Deamination; Dideoxynucleosides; Guanine; Humans; Organophosphorus Compounds; Prodrugs; Rats; Tumor Cells, Cultured

1999
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
    Biochemical pharmacology, 1999, Jul-15, Volume: 58, Issue:2

    Topics: Adenine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Antineoplastic Agents; Cell Cycle; Cell Differentiation; Cell Division; Deoxyadenine Nucleotides; Drug Interactions; Drug Screening Assays, Antitumor; Erythrocytes; Guanine; Humans; K562 Cells; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Pentostatin; Prodrugs; Rats; Tumor Cells, Cultured

1999
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
    Oncology research, 1999, Volume: 11, Issue:4

    Topics: Adenine; Animals; Antineoplastic Agents; Choriocarcinoma; Female; Guanine; Male; Organophosphonates; Organophosphorus Compounds; Pregnancy; Prodrugs; Rats; Tumor Cells, Cultured; Uterine Neoplasms

1999
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
    Molecular pharmacology, 1999, Volume: 56, Issue:6

    Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured

1999
Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
    Biochemical pharmacology, 2000, Dec-15, Volume: 60, Issue:12

    Topics: Adenine; Animals; Antineoplastic Agents; Guanine; Guanosine Monophosphate; Guanylate Kinases; Isoenzymes; Kinetics; Nucleoside-Phosphate Kinase; Organophosphorus Compounds; Phosphorylation; Substrate Specificity; Swine

2000
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
    Biochemical pharmacology, 2006, Apr-28, Volume: 71, Issue:9

    Topics: Adenine; Aminohydrolases; Animals; Catalysis; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Guanine; In Vitro Techniques; Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley

2006
Tricyclic etheno analogs of PMEG and PMEDAP: synthesis and biological activity.
    Bioorganic & medicinal chemistry, 2006, Dec-01, Volume: 14, Issue:23

    Topics: Adenine; Antiviral Agents; Cell Proliferation; Cytomegalovirus; Guanine; Herpesvirus 3, Human; Humans; Organophosphorus Compounds; Structure-Activity Relationship

2006
In vivo modulation of angiogenic gene expression by acyclic nucleoside phosphonates PMEDAP and PMEG.
    Anticancer research, 2009, Volume: 29, Issue:4

    Topics: Adenine; Animals; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 1; Gene Expression Regulation, Neoplastic; Guanine; Lymphoma, T-Cell; Male; Neovascularization, Pathologic; Organophosphorus Compounds; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Platelet-Derived Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

2009
Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
    Chemotherapy, 2010, Volume: 56, Issue:1

    Topics: Adenine; Animals; Antineoplastic Agents; Female; Guanine; HeLa Cells; Humans; Mice; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured; Uterine Cervical Neoplasms

2010
Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
    European journal of pharmacology, 2010, Sep-15, Volume: 643, Issue:1

    Topics: Adenine; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Guanine; Humans; In Situ Hybridization, Fluorescence; Organophosphorus Compounds; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; RNA; Telomerase; Telomere; Time Factors

2010
Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
    Biochemical pharmacology, 2011, Jul-15, Volume: 82, Issue:2

    Topics: Adenine; Adenylate Kinase; Amino Acid Sequence; Antineoplastic Agents; Cells, Cultured; Drug Resistance, Neoplasm; Guanine; Guanylate Kinases; Humans; Molecular Sequence Data; Organophosphorus Compounds; Phosphorylation; Point Mutation

2011
Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
    Anticancer research, 2012, Volume: 32, Issue:2

    Topics: Adenine; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Guanine; HL-60 Cells; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Organophosphorus Compounds; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger

2012