adenine and 8-hydroxyadenine

adenine has been researched along with 8-hydroxyadenine in 78 studies

Research

Studies (78)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (6.41)	18.7374
1990's	24 (30.77)	18.2507
2000's	30 (38.46)	29.6817
2010's	15 (19.23)	24.3611
2020's	4 (5.13)	2.80

Authors

Authors	Studies
Abdelrahman, A; Alksnis, E; Borrmann, T; Cristalli, G; Gorzalka, S; Knospe, M; Lambertucci, C; Müller, CE; Schiedel, AC; Volpini, R	1
Cameron, JS; McBurney, A; Simmonds, HA; Van Acker, KJ	1
Brown, T; Guy, A; Hunter, WN; Leonard, GA; Téoule, R	1
Essigmann, JM; Esteve, A; Kuziemko, GM; Morningstar, ML; Wood, ML	1
Bhan, P; Cushman, CD; Miller, PS; Trapane, TL	1
Haimanot, R; Malins, DC	2
Duplaa, AM; Fazakerley, GV; Guschlbauer, W; Guy, A; Téoule, R	1
Guy, A; Molko, D; Téoule, R	1
Duplaa, AM; Guy, A; Teoule, R	1
Ward, JF; West, GJ; West, IW	1
Hanaoka, F; Inoue, H; Ishikawa, H; Kamiya, H; Masutani, C; Miura, H; Murata-Kamiya, N; Nishimura, S; Sakaguchi, T; Sasaki, T	1
Fuciarelli, AF; Miller, DL; Sisk, EC; Thomas, RM	1
Leukel, P; Mayer, KK; Müller, K; Wiegrebe, W	1
Ho, YS; Lin, JK; Lo, MJ; Wang, YJ	1
Hobbs, FW; Jetter, MC	1
Garner, MM; Gunselman, SJ; Malins, DC; Polissar, NL	1
Aruoma, OI; England, TG; Halliwell, B; Jenner, A	2
Burrows, CJ; Duarte, V; Hickerson, RP; Muller, JG	1
Griffiths, HR; Herbert, KE; Lunec, J; Mistry, N; Mistry, P; Podmore, ID	1
Boiteux, S; Cadet, J; D'Ham, C; Girard, PM	1
Dix, TA; Simandan, T; Sun, J	1
Gabbita, SP; Lovell, MA; Markesbery, WR	1
Dizdaroglu, M	1
Foksinski, M; Jaruga, P; Makarewicz, R; Olinski, R	1
Dizdaroglu, M; Sentürker, S	1
Halota, W; Jaruga, B; Jaruga, P; Olczak, A; Olinski, R	1
Osheroff, N; Sabourin, M	1
Fukuoka, M; Inoue, H; Ohtsuka, E; Terashima, Y	1
Bohr, VA; Ganunis, R; Machwe, A; Orren, DK	1
Kozai, S; Maruyama, T; Sasaki, F	1
Malins, DC; Ostrander, GK; Polissar, NL; Vinson, MA	1
Bohr, VA; Cooper, MP; Karmakar, P; Machwe, A; Orren, DK; Piotrowski, J	1
Barker, EA; Johnson, PM; Malins, DC; Polissar, NL; Vinson, MA; Wheeler, TM	1
Gorenstein, DG; House, PG; Lloyd, RS; Luxon, BA; Manuel, RC; Thiviyanathan, V; Volk, DE	1
Barone, F; Cellai, L; Giordano, C; La Sala, G; Mazzei, F	1
Dawson, R; Messina, SA	1
Funk, MC; Hunt, CR; Parsian, AJ; Tao, TY	1
England, TG; Halliwell, B; Proteggente, AR; Rehman, A; Rice-Evans, CA	1
Bohr, VA; Dizdaroglu, M; Jaruga, P; Rodriguez, H; Tuo, J	2
Allgayer, H; Kolb, M; Kruis, W; Stuber, V	1
Dogliotti, E; Fortini, P; Laval, J; Macpherson, P; Parlanti, E	1
Bohr, VA; Calvayrac, G; Jensen, A; Karahalil, B; Stevnsner, T	1
Hayashi, H; Hirota, K; Isobe, Y; Kawakami, H; Kurimoto, A; Ogino, T; Ogita, H; Sajiki, H; Takaku, H; Tobe, M	1
DUNN, JT; WYNGAARDEN, JB	1
Hirota, K; Ichii, S; Isobe, Y; Kawakami, H; Kurimoto, A; Ogino, T; Ogita, H; Sajiki, H; Takaku, H; Tobe, M	2
Dizdaroglu, M; Jaruga, P; O'Connor, T; Reddy, P; Rodriguez, H	1
Dizdaroglu, M; Evans, MK; Jaruga, P; Lohani, A; Nyaga, SG; Trzeciak, AR	1
Gutala, RV; Jung, Y; Manczak, M; McWeeney, S; Mori, M; Park, BS; Partovi, D; Quinn, J; Reddy, PH; Searles, R; Yau, V	1
Cunniffe, S; Lomax, ME; O'Neill, P; Salje, H	1
Broyde, S; Grollman, AP; Perlow-Poehnelt, RA; Zharkov, DO	1
Drijfhout, JW; Filippov, DV; Khan, S; Melief, CJ; Ossendorp, F; Overkleeft, HS; van der Burg, SH; van der Heden, GJ; van der Marel, GA; Weterings, JJ	1
Gutowski, M; Harańczyk, M; Miller, JH	1
Handa, H; Hayashida, M; Ikegami, T; Ito, S; Kuraoka, I; Kwei, JS; Nakabeppu, Y; Suzuki, K; Tanaka, K	1
Filippov, DV; Khan, S; Melief, CJ; Ossendorp, F; Overkleeft, HS; van der Burg, SH; van der Heden van Noort, GJ; van der Marel, GA; Weterings, JJ	1
Hitomi, K; Perry, JJ; Tainer, JA	1
Dianov, GL; Grin, IR; Zharkov, DO	1
Bonnert, R; Hashimoto, K; Isobe, Y; Kurimoto, A; McInally, T; Nakamura, T; Norimura, K; Ogita, H; Takaku, H; Wada, H	1
Puranik, M; Shanmugasundaram, M	1
Beckett, TL; Bradley, MA; Dowling, AL; LeVine, H; Lovell, MA; Matveev, SV; Murphy, MP; Niedowicz, DM; Weidner, AM	1
Aoki, M; Benjamin, AD; Biffen, M; Doyle, I; Edwards, S; Eiho, K; Fraser, NJ; Hawkins, SL; Holness, E; Leishman, AJ; Matsui, H; McInally, T; Murray, CM; Satterthwaite, G; Takaku, H; Tomizawa, H; Wada, H	1
Couvé, S; Ishchenko, AA; Kunz, C; Saparbaev, M; Schär, P; Talhaoui, I	1
Bonnert, R; Isobe, Y; Kurebayashi, H; McInally, T; Nakamura, T; Wada, H	1
Chauleau, M; Shuman, S	1
Bazin, HG; Evans, JT; Johnson, DA; Khalaf, JK; Li, Y; Livesay, MT; Mwakwari, S	1
Bose, N; Meyer, JM; Schroeder, FC; Sommer, RJ; Yim, JJ	1
Chen, J; Diao, Y; Gao, D; Gao, N; Hu, Y; Jiang, W; Jin, G; Li, W; Liu, Y; Wang, X; Wang, Z; Zeng, J	1
Francés-Monerris, A; Merchán, M; Roca-Sanjuán, D	1
Chang, SJ; Choi, YJ; Gibala, KS; Resendiz, MJE	1
Bednárová, K; Dvoráková, Z; Kejnovská, I; Renciuk, D; Sagi, J; Školáková, P; Vorlícková, M	1
Jung, H; Koag, MC; Lee, S	2
Bazin, HG; Bess, LS; Cybulski, V; Evans, JT; Johnson, DA; Li, Y; Livesay, MT; Miller, SM	1
Jung, H; Lee, S	2

Reviews

3 review(s) available for adenine and 8-hydroxyadenine

Article	Year
Facts about the artifacts in the measurement of oxidative DNA base damage by gas chromatography-mass spectrometry. Free radical research, 1998, Volume: 29, Issue:6 Topics: Adenine; Animals; Artifacts; Base Pairing; Cattle; Cytosine; DNA; DNA Damage; DNA Repair; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Oxidation-Reduction; Oxidative Stress; Pentoxyl; Pyrimidines; Temperature; Thymus Gland	1998
Potential double-flipping mechanism by E. coli MutY. Progress in nucleic acid research and molecular biology, 2001, Volume: 68 Topics: Adenine; Amino Acid Sequence; Bacterial Proteins; Base Pair Mismatch; Carbon-Oxygen Lyases; Catalysis; Catalytic Domain; Deoxyribonuclease IV (Phage T4-Induced); DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Guanine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; N-Glycosyl Hydrolases; Phosphoric Monoester Hydrolases; Protein Conformation; Protein Structure, Tertiary; Pyrophosphatases; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Substrate Specificity	2001
8-Oxo-7,8-dihydroadenine and 8-Oxo-7,8-dihydroadenosine-Chemistry, Structure, and Function in RNA and Their Presence in Natural Products and Potential Drug Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany), 2017, May-17, Volume: 23, Issue:28 Topics: Adenine; Adenosine; Biological Products; Oxidation-Reduction; Purine Nucleotides; RNA; Spectrophotometry	2017

Trials

2 trial(s) available for adenine and 8-hydroxyadenine

Article	Year
Vitamin C exhibits pro-oxidant properties. Nature, 1998, Apr-09, Volume: 392, Issue:6676 Topics: Adenine; Adult; Antioxidants; Ascorbic Acid; Dietary Supplements; DNA; DNA Damage; Female; Gas Chromatography-Mass Spectrometry; Humans; Lymphocytes; Male; Middle Aged; Oxidants; Reactive Oxygen Species	1998
Oxidative DNA base damage in lymphocytes of HIV-infected drug users. Free radical research, 1999, Volume: 31, Issue:3 Topics: Adenine; Adolescent; Adult; Chromatin; Cytosine; DNA Damage; Guanine; HIV Infections; Humans; Lymphocytes; Male; Oxidation-Reduction; Oxidative Stress; Substance Abuse, Intravenous; Uracil	1999

Other Studies

73 other study(ies) available for adenine and 8-hydroxyadenine

Article	Year
Structure-activity relationships of adenine and deazaadenine derivatives as ligands for adenine receptors, a new purinergic receptor family. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Adenine; Animals; Astrocytoma; Cell Line; Cell Line, Tumor; Cerebral Cortex; Humans; Ligands; Protein Binding; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Tubercidin	2009
Purine excretion in complete adenine phosphoribosyltransferase deficiency: effect of diet and allopurinol therapy. Advances in experimental medicine and biology, 1977, Volume: 76B Topics: Adenine; Adenine Phosphoribosyltransferase; Allopurinol; Child, Preschool; Diet; Humans; Male; Orotic Acid; Pentosyltransferases; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid	1977
Conformation of guanine-8-oxoadenine base pairs in the crystal structure of d(CGCGAATT(O8A)GCG). Biochemistry, 1992, Sep-15, Volume: 31, Issue:36 Topics: Adenine; Base Sequence; Guanine; Hydrogen Bonding; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; X-Ray Diffraction	1992
Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli. Nucleic acids research, 1992, Nov-25, Volume: 20, Issue:22 Topics: Adenine; Bacteriophage M13; Base Sequence; Chromatography, High Pressure Liquid; DNA Damage; DNA, Recombinant; Escherichia coli; Guanine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutagenicity Tests; Mutagens; Oligodeoxyribonucleotides; Oxidation-Reduction; Restriction Mapping; Transformation, Bacterial	1992
Recognition of a guanine-cytosine base pair by 8-oxoadenine. Biochemistry, 1992, Jul-28, Volume: 31, Issue:29 Topics: Adenine; Base Composition; Base Sequence; Cytosine; Guanine; Hydrogen Bonding; Models, Structural; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Thermodynamics	1992
Major alterations in the nucleotide structure of DNA in cancer of the female breast. Cancer research, 1991, Oct-01, Volume: 51, Issue:19 Topics: Adenine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Transformation, Neoplastic; Chromatography, Gas; DNA; Female; Guanine; Humans; Hydroxylation; Mass Spectrometry; Pyrimidines	1991
Structure and in vitro replication of DNA templates containing 7,8-dihydro-8-oxoadenine. Nucleic acids research, 1991, Apr-25, Volume: 19, Issue:8 Topics: Adenine; Base Composition; Base Sequence; DNA; DNA Replication; Electrophoresis, Polyacrylamide Gel; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oxidation-Reduction; Protons; Templates, Genetic	1991
4,6-Diamino-5-formamidopyrimidine, 8-hydroxyguanine and 8-hydroxyadenine in DNA from neoplastic liver of English sole exposed to carcinogens. Biochemical and biophysical research communications, 1990, Dec-14, Volume: 173, Issue:2 Topics: Adenine; Animals; Carcinogens; DNA, Neoplasm; Flatfishes; Free Radicals; Hydroxides; Hydroxyl Radical; Liver Neoplasms; Pyrimidines	1990
Synthesis of DNA fragments bearing 7,8-dihydro-8-oxo-adenine: a gamma radiation product. Nucleic acids symposium series, 1989, Issue:21 Topics: Adenine; DNA; Gamma Rays; Models, Chemical; Oligodeoxyribonucleotides	1989
Measurement of the radiosensitivity of a radiation-induced adenine defect in a single stranded DNA chain. Radiation and environmental biophysics, 1989, Volume: 28, Issue:3 Topics: Adenine; DNA, Single-Stranded; Electronic Data Processing; Electrophoresis, Polyacrylamide Gel; Gamma Rays; Oligonucleotides; Radiation Tolerance	1989
Radioimmunoassay of 7,8-dihydro-8-oxoadenine (8-hydroxyadenine). International journal of radiation biology and related studies in physics, chemistry, and medicine, 1982, Volume: 42, Issue:5 Topics: Adenine; DNA; Radioimmunoassay	1982
8-Hydroxyadenine (7,8-dihydro-8-oxoadenine) induces misincorporation in in vitro DNA synthesis and mutations in NIH 3T3 cells. Nucleic acids research, 1995, Aug-11, Volume: 23, Issue:15 Topics: 3T3 Cells; Adenine; Amino Acid Sequence; Animals; Base Sequence; DNA; DNA Damage; DNA Mutational Analysis; DNA-Directed DNA Polymerase; DNA, Single-Stranded; Escherichia coli; Genes, ras; Mice; Molecular Sequence Data; Mutagens; Polydeoxyribonucleotides; Rats; Templates, Genetic; Transfection	1995
Induction of base damage in DNA solutions by ultrasonic cavitation. Free radical biology & medicine, 1995, Volume: 18, Issue:2 Topics: Adenine; Animals; Cattle; Cytosine; DNA Damage; Free Radicals; Gas Chromatography-Mass Spectrometry; Hydrogen Peroxide; Hydroxyl Radical; Purines; Pyrimidines; Thymine; Ultrasonics	1995
Modification of DNA bases by anthralin and related compounds. Biochemical pharmacology, 1995, May-26, Volume: 49, Issue:11 Topics: Adenine; Animals; Anthralin; Cattle; Dermatologic Agents; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Hydroxylation; Pyrimidines	1995
Oxidative modification of DNA bases in rat liver and lung during chemical carcinogenesis and aging. Chemico-biological interactions, 1995, Volume: 94, Issue:2 Topics: 2-Acetylaminofluorene; Adenine; Aging; Animals; Antineoplastic Agents; Disease Models, Animal; DNA Damage; DNA, Neoplasm; Gas Chromatography-Mass Spectrometry; Guanine; Hydrolysis; Liver; Liver Neoplasms, Experimental; Lung; Lung Neoplasms; Male; Methylamines; Nitrates; Oxidation-Reduction; Pyrimidines; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thymine; Uracil	1995
7,8-Dihydro-8-oxoadenine as a replacement for cytosine in the third strand of triple helices. Triplex formation without hypochromicity. Biochemistry, 1993, Apr-06, Volume: 32, Issue:13 Topics: Adenine; Base Sequence; Cytosine; Hot Temperature; Hydrogen-Ion Concentration; Molecular Sequence Data; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligodeoxyribonucleotides; Spectrophotometry, Ultraviolet; Structure-Activity Relationship	1993
Mutagenic DNA base modifications are correlated with lesions in nonneoplastic hepatic tissue of the English sole carcinogenesis model. Cancer research, 1996, Dec-15, Volume: 56, Issue:24 Topics: Adenine; Age Factors; Animals; Confounding Factors, Epidemiologic; Fish Diseases; Guanine; Liver Diseases; Liver Neoplasms; Mutagenesis; Precancerous Conditions	1996
Measurement of oxidative DNA damage by gas chromatography-mass spectrometry: ethanethiol prevents artifactual generation of oxidized DNA bases. The Biochemical journal, 1998, Apr-15, Volume: 331 ( Pt 2) Topics: Adenine; Animals; Cattle; Cytosine; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Guanine Deaminase; Oxidation-Reduction; Pentoxyl; Sulfhydryl Compounds; Temperature	1998
Gel electrophoretic detection of 7,8-dihydro-8-oxoguanine and 7, 8-dihydro-8-oxoadenine via oxidation by Ir (IV). Nucleic acids research, 1998, May-01, Volume: 26, Issue:9 Topics: Adenine; DNA Damage; DNA Primers; Electrophoresis, Polyacrylamide Gel; Guanine; Iridium; Oxidation-Reduction	1998
Opposite base-dependent excision of 7,8-dihydro-8-oxoadenine by the Ogg1 protein of Saccharomyces cerevisiae. Carcinogenesis, 1998, Volume: 19, Issue:7 Topics: 5-Methylcytosine; Adenine; Bacterial Proteins; Cytosine; DNA; DNA Glycosylases; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Escherichia coli; Escherichia coli Proteins; Fungal Proteins; Humans; N-Glycosyl Hydrolases; Oligonucleotides; Purines; Pyridines; Saccharomyces cerevisiae	1998
Oxidation of DNA bases, deoxyribonucleosides and homopolymers by peroxyl radicals. The Biochemical journal, 1998, Oct-15, Volume: 335 ( Pt 2) Topics: Adenine; Amidines; Base Pairing; Cytosine; Deoxyribonucleosides; DNA; Free Radicals; Guanine; Mass Spectrometry; Oxidation-Reduction; Purines; Pyrimidines; Reactive Oxygen Species; Thymine	1998
Increased nuclear DNA oxidation in the brain in Alzheimer's disease. Journal of neurochemistry, 1998, Volume: 71, Issue:5 Topics: Adenine; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cadaver; Cell Nucleus; Cytosine; DNA; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Oxidation-Reduction; Pyrimidines; Reference Values; Tissue Distribution	1998
Determination of oxidative DNA base damage by gas chromatography-mass spectrometry. Effect of derivatization conditions on artifactual formation of certain base oxidation products. Free radical research, 1998, Volume: 29, Issue:4 Topics: Adenine; Animals; Artifacts; Cytosine; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Guanine; Hydantoins; Hydrolysis; Nitrogen; Oxidation-Reduction; Pentoxyl; Purines; Pyrimidines; Temperature; Time Factors	1998
Oxidative DNA base damage in cancerous tissues of patients undergoing brachytherapy. Cancer letters, 1998, Oct-23, Volume: 132, Issue:1-2 Topics: Adenine; Brachytherapy; Cytosine; DNA Damage; DNA, Neoplasm; Female; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Oxidation-Reduction; Pyrimidines; Uracil; Uterine Cervical Neoplasms	1998
The effect of experimental conditions on the levels of oxidatively modified bases in DNA as measured by gas chromatography-mass spectrometry: how many modified bases are involved? Prepurification or not? Free radical biology & medicine, 1999, Volume: 27, Issue:3-4 Topics: Adenine; Animals; Artifacts; Cattle; Cytosine; DNA; Gas Chromatography-Mass Spectrometry; Guanine; Hydrolysis; Nucleotides; Oxidation-Reduction; Pentoxyl; Trifluoroacetic Acid; Uracil	1999
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions. Nucleic acids research, 2000, May-01, Volume: 28, Issue:9 Topics: Adenine; Alkylation; Apurinic Acid; Base Sequence; DNA; DNA Adducts; DNA Damage; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Guanine; Humans; Isoenzymes; Mutation; Oligonucleotides; Oxidation-Reduction; Plasmids; Sensitivity and Specificity	2000
Further studies of KMnO4 oxidation of synthetic DNAs containing oxidatively damaged bases. Nucleic acids symposium series, 1999, Issue:42 Topics: Adenine; Base Sequence; DNA; DNA Damage; Guanine; Oligodeoxyribonucleotides; Oxidation-Reduction; Potassium Permanganate; Uracil	1999
Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. Nucleic acids research, 2000, Jul-15, Volume: 28, Issue:14 Topics: Adenine; Base Sequence; DNA; DNA Adducts; DNA Helicases; DNA Polymerase I; Exodeoxyribonucleases; Exonucleases; Guanine; Hypoxanthine; Mutation; Oxidation-Reduction; RecQ Helicases; Substrate Specificity; Uracil; Werner Syndrome Helicase	2000
Method for the synthesis of uric acid derivatives. Nucleosides, nucleotides & nucleic acids, 2000, Volume: 19, Issue:7 Topics: 1-Propanol; Adenine; Alkylation; Ammonia; Guanine; Hydrocarbons, Iodinated; Mass Spectrometry; Methylation; Purines; Uric Acid	2000
Single 8-oxo-guanine and 8-oxo-adenine lesions induce marked changes in the backbone structure of a 25-base DNA strand. Proceedings of the National Academy of Sciences of the United States of America, 2000, Nov-07, Volume: 97, Issue:23 Topics: Adenine; DNA; DNA Damage; Guanine; Hydroxyl Radical; Multivariate Analysis; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Spectroscopy, Fourier Transform Infrared	2000
A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA. Nucleic acids research, 2001, May-01, Volume: 29, Issue:9 Topics: Adenine; Antigens, Nuclear; Cell Line; Cell Nucleus; DNA; DNA Damage; DNA Helicases; DNA-Binding Proteins; Exodeoxyribonucleases; Exonucleases; Guanine; HeLa Cells; Humans; Ku Autoantigen; Nuclear Proteins; RecQ Helicases; Replication Protein A; Werner Syndrome Helicase	2001
Age-related radical-induced DNA damage is linked to prostate cancer. Cancer research, 2001, Aug-15, Volume: 61, Issue:16 Topics: Adenine; Age Factors; Cell Transformation, Neoplastic; DNA; DNA Damage; DNA, Neoplasm; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Hydroxyl Radical; Logistic Models; Male; Middle Aged; Models, Biological; Prostate; Prostatic Neoplasms; Pyrimidines	2001
Influence of an 8-oxoadenine lesion on the structural and dynamic features of a 30-mer DNA fragment with and without a mismatch. International journal of radiation biology, 2002, Volume: 78, Issue:1 Topics: Adenine; Anisotropy; Base Pair Mismatch; Base Sequence; Circular Dichroism; DNA; DNA Damage; Gamma Rays; Hydrogen-Ion Concentration; Models, Statistical; Molecular Sequence Data; Nucleic Acid Conformation; Oligonucleotides; Oxygen; Protein Conformation; Spectrometry, Fluorescence; Ultraviolet Rays	2002
Attenuation of oxidative damage to DNA by taurine and taurine analogs. Advances in experimental medicine and biology, 2000, Volume: 483 Topics: Adenine; Animals; Antioxidants; Cattle; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Hydrogen Peroxide; Oxidants; Oxidative Stress; Structure-Activity Relationship; Taurine; Uracil	2000
The effect of DNA damage on the formation of protein/DNA complexes. Mutation research, 2002, Apr-25, Volume: 501, Issue:1-2 Topics: Adenine; Binding Sites; DNA; DNA Damage; DNA-Binding Proteins; Guanine; Promoter Regions, Genetic; Protein Binding; Transcription Factor AP-1	2002
Gender differences in steady-state levels of oxidative damage to DNA in healthy individuals. Free radical research, 2002, Volume: 36, Issue:2 Topics: Adenine; Adult; Ascorbic Acid; Cytosine; DNA; DNA Damage; Female; Gas Chromatography-Mass Spectrometry; Health; Humans; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Pyrimidines; Sex Characteristics	2002
The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA. The Journal of biological chemistry, 2002, Aug-23, Volume: 277, Issue:34 Topics: Adenine; DNA Helicases; DNA Repair; DNA Repair Enzymes; Gamma Rays; Guanine; Humans; Poly-ADP-Ribose Binding Proteins	2002
Effects of bile acids on base hydroxylation in a model of human colonic mucosal DNA. Cancer detection and prevention, 2002, Volume: 26, Issue:1 Topics: Adenine; Animals; Cattle; Chenodeoxycholic Acid; Colon; Colonic Neoplasms; Deoxycholic Acid; DNA; DNA Damage; Gas Chromatography-Mass Spectrometry; Gastrointestinal Agents; Guanine; Humans; Hydroxylation; Intestinal Mucosa; Models, Chemical; Reactive Oxygen Species; Salicylates; Thymus Gland	2002
Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts. Oncogene, 2002, Aug-08, Volume: 21, Issue:34 Topics: Adenine; Aphidicolin; Base Pair Mismatch; Base Pairing; Cell Extracts; DNA; DNA Primers; DNA Repair; Drug Resistance; Enzyme Inhibitors; Guanine; HeLa Cells; Humans; Nucleic Acid Synthesis Inhibitors	2002
Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei. The Journal of biological chemistry, 2003, May-23, Volume: 278, Issue:21 Topics: Adenine; Animals; Base Pairing; Base Sequence; Cell Line, Transformed; Cell Nucleus; Cytosine; DNA; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Fibroblasts; Guanine; Humans; Liver; Magnesium; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; N-Glycosyl Hydrolases; Nucleic Acid Conformation; Oligonucleotides; Substrate Specificity	2003
Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6 Topics: Adenine; Adult; Cell Line; Child; Child, Preschool; Cockayne Syndrome; DNA; DNA Damage; DNA Repair; Endonucleases; Exonucleases; Female; Guanine; Humans; Infant; Male; Oxidative Stress	2003
Synthesis and structure-activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects. Bioorganic & medicinal chemistry, 2003, Aug-15, Volume: 11, Issue:17 Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Imiquimod; Interferon Inducers; Mice; Mice, Inbred BALB C; Spleen; Structure-Activity Relationship; Vomiting	2003
8-Hydroxyadenine as the intermediate in the oxidation of adenine to 2, 8-dihydroxyadenine by xanthine oxidase. Archives of biochemistry and biophysics, 1957, Volume: 70, Issue:1 Topics: Adenine; Biochemical Phenomena; Oxidation-Reduction; Oxidoreductases; Xanthine Oxidase	1957
Synthesis and structure-activity relationships of 2-amino-8-hydroxyadenines as orally active interferon inducing agents. Bioorganic & medicinal chemistry, 2003, Dec-01, Volume: 11, Issue:24 Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Imiquimod; Interferon Inducers; Interferons; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Molecular Structure; Spleen; Structure-Activity Relationship	2003
Overexpression and rapid purification of Escherichia coli formamidopyrimidine-DNA glycosylase. Protein expression and purification, 2004, Volume: 34, Issue:1 Topics: Adenine; Carboxymethylcellulose Sodium; Chromatography, DEAE-Cellulose; Cloning, Molecular; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation, Bacterial; Genetic Vectors; Guanine; Kinetics; Nitrous Oxide; Pyrimidines; Recombinant Proteins; Substrate Specificity; Temperature	2004
Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities. Bioorganic & medicinal chemistry, 2004, Mar-01, Volume: 12, Issue:5 Topics: Adenine; Administration, Oral; Aminoquinolines; Animals; Biological Availability; Cells, Cultured; Dose-Response Relationship, Drug; Hepatitis C; Imiquimod; Interferons; Mice; Rats; Structure-Activity Relationship	2004
Cellular repair of oxidatively induced DNA base lesions is defective in prostate cancer cell lines, PC-3 and DU-145. Carcinogenesis, 2004, Volume: 25, Issue:8 Topics: Adenine; Antioxidants; Blotting, Western; Catalase; Cell Division; Cell Line, Tumor; Cell Nucleus; Comet Assay; Cytosine; DNA; DNA Damage; Dose-Response Relationship, Drug; Electron Transport Complex IV; Gas Chromatography-Mass Spectrometry; Glutathione Peroxidase; Guanine; Humans; Kinetics; Male; Mitochondria; Oxygen; Polymorphism, Genetic; Prostatic Neoplasms; Superoxide Dismutase; Time Factors	2004
Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease. Human molecular genetics, 2004, Jun-15, Volume: 13, Issue:12 Topics: Adenine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain; Fluorescent Antibody Technique; Gene Expression Profiling; Heat-Shock Proteins; In Situ Hybridization; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oligonucleotide Array Sequence Analysis; Oxidative Phosphorylation Coupling Factors; Oxidative Stress; Reproducibility of Results; RNA, Messenger	2004
8-OxoA inhibits the incision of an AP site by the DNA glycosylases Fpg, Nth and the AP endonuclease HAP1. Radiation research, 2005, Volume: 163, Issue:1 Topics: Adenine; Base Sequence; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Formamidopyrimidine Glycosylase; Escherichia coli Proteins; Molecular Sequence Data; Purines; Pyrimidines; Radiation Dosage; Structure-Activity Relationship	2005
Substrate discrimination by formamidopyrimidine-DNA glycosylase: distinguishing interactions within the active site. Biochemistry, 2004, Dec-28, Volume: 43, Issue:51 Topics: Adenine; Catalytic Domain; Computer Simulation; DNA; DNA-Formamidopyrimidine Glycosylase; Guanine; Models, Molecular; Protein Structure, Tertiary; Substrate Specificity	2004
Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines. Bioorganic & medicinal chemistry letters, 2006, Jun-15, Volume: 16, Issue:12 Topics: Adenine; Antigen Presentation; Dendritic Cells; Epitopes; Histocompatibility Antigens Class I; Interleukin-12; Molecular Structure; Peptides; Vaccines	2006
Differences in electrostatic potential around DNA fragments containing adenine and 8-oxo-adenine. An analysis based on regular cylindrical projection. Journal of molecular graphics & modelling, 2007, Volume: 26, Issue:1 Topics: Adenine; Computer Simulation; DNA; DNA Damage; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Static Electricity	2007
RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. DNA repair, 2007, Jun-01, Volume: 6, Issue:6 Topics: Adenine; Base Sequence; DNA Damage; DNA Repair; Guanine; HeLa Cells; Humans; Models, Chemical; Models, Genetic; Molecular Sequence Data; Oxygen; RNA Polymerase II; Thymine; Transcription, Genetic; Transcriptional Elongation Factors	2007
2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation. Bioorganic & medicinal chemistry letters, 2009, Apr-15, Volume: 19, Issue:8 Topics: Adenine; Amines; Animals; Azides; Cell Differentiation; Dendritic Cells; Mice; Toll-Like Receptor 7	2009
Flexibility promotes fidelity. Structure (London, England : 1993), 2009, May-13, Volume: 17, Issue:5 Topics: Adenine; Animals; Base Pair Mismatch; DNA Mismatch Repair; DNA-Directed DNA Polymerase; Guanine; Humans	2009
The role of mammalian NEIL1 protein in the repair of 8-oxo-7,8-dihydroadenine in DNA. FEBS letters, 2010, Apr-16, Volume: 584, Issue:8 Topics: Adenine; Animals; Base Pair Mismatch; Base Sequence; DNA; DNA Glycosylases; DNA Repair; Humans; Kinetics; Mice	2010
Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7 Topics: Adenine; Animals; Carboxylic Acids; Cell Line; Drug Stability; Humans; Hypersensitivity; Immunotherapy; Inflammation; Interferons; Male; Rats; Toll-Like Receptor 7	2010
Vibrational markers of structural distortion in adenine nucleobases upon DNA damage. Physical chemistry chemical physics : PCCP, 2011, Mar-07, Volume: 13, Issue:9 Topics: Adenine; DNA; DNA Damage; Electrochemical Techniques; Hydrogen Bonding; Pyrimidines; Spectrum Analysis, Raman; Thermodynamics; Vibration	2011
RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease. PloS one, 2011, Volume: 6, Issue:9 Topics: Adenine; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Brain; Case-Control Studies; DNA Damage; Enzyme-Linked Immunosorbent Assay; Female; Gas Chromatography-Mass Spectrometry; Guanine; Humans; Male; Neurofibrillary Tangles; Oxidation-Reduction; Plaque, Amyloid; RNA	2011
Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. British journal of pharmacology, 2012, Volume: 166, Issue:2 Topics: Acetates; Adenine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage Fluid; Cells, Cultured; Cytokines; Disease Models, Animal; Dogs; Female; Gene Expression Regulation; HEK293 Cells; Humans; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ovalbumin; Rats; Respiratory Hypersensitivity; RNA, Messenger; Spleen; Toll-Like Receptor 7	2012
7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases. Nucleic acids research, 2013, Volume: 41, Issue:2 Topics: Adenine; Animals; Base Pairing; Cell Line; DNA Adducts; DNA Repair; Escherichia coli; Humans; Mice; Mutagenesis; Radiation, Ionizing; Thymine; Thymine DNA Glycosylase	2013
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3 Topics: Adenine; Administration, Intravenous; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; HEK293 Cells; Humans; Mice; Molecular Structure; Solubility; Toll-Like Receptor 7; Water	2013
Kinetic mechanism of nick sealing by T4 RNA ligase 2 and effects of 3'-OH base mispairs and damaged base lesions. RNA (New York, N.Y.), 2013, Volume: 19, Issue:12 Topics: Adenine; Apurinic Acid; Base Pairing; Base Sequence; Escherichia coli; Guanine; Kinetics; RNA Ligase (ATP); RNA, Double-Stranded; Viral Proteins	2013
Structural requirements for TLR7-selective signaling by 9-(4-piperidinylalkyl)-8-oxoadenine derivatives. Bioorganic & medicinal chemistry letters, 2015, Mar-15, Volume: 25, Issue:6 Topics: Adenine; Cell Survival; HEK293 Cells; Humans; Interferon-alpha; Leukocytes, Mononuclear; NF-kappa B; Signal Transduction; Toll-Like Receptor 7; Toll-Like Receptor 8; Transfection	2015
Nematode signaling molecules derived from multimodular assembly of primary metabolic building blocks. Organic letters, 2015, Apr-03, Volume: 17, Issue:7 Topics: Adenine; Animals; Biological Evolution; Caenorhabditis elegans; Molecular Structure; Nematoda; Nucleosides; Signal Transduction; Tryptophan	2015
Conjugation of weak ligands with weak antigens to activate TLR-7: A step toward better vaccine adjuvants. European journal of medicinal chemistry, 2016, Sep-14, Volume: 120 Topics: Adenine; Adjuvants, Immunologic; Animals; Antigens; Cytokines; Immunoconjugates; Immunoglobulin G; Ligands; Membrane Glycoproteins; Mice; Structure-Activity Relationship; Toll-Like Receptor 7; Vaccines	2016
Mechanism of the OH Radical Addition to Adenine from Quantum-Chemistry Determinations of Reaction Paths and Spectroscopic Tracking of the Intermediates. The Journal of organic chemistry, 2017, 01-06, Volume: 82, Issue:1 Topics: Adenine; Hydroxyl Radical; Nucleic Acid Conformation; Pyrimidines; Quantum Theory	2017
i-Motif of cytosine-rich human telomere DNA fragments containing natural base lesions. Nucleic acids research, 2018, 02-28, Volume: 46, Issue:4 Topics: Adenine; Cytosine; DNA; DNA Damage; Humans; Pentoxyl; Telomere; Uracil	2018
Mutagenic Replication of the Major Oxidative Adenine Lesion 7,8-Dihydro-8-oxoadenine by Human DNA Polymerases. Journal of the American Chemical Society, 2019, 03-20, Volume: 141, Issue:11 Topics: Adenine; Catalytic Domain; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Mutagenesis; Mutation; Protein Binding; Protein Conformation, alpha-Helical	2019
Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity. Bioorganic & medicinal chemistry letters, 2020, 03-15, Volume: 30, Issue:6 Topics: Adenine; Adjuvants, Immunologic; Cytokines; Humans; Leukocytes, Mononuclear; Quinolines; Structure-Activity Relationship; Toll-Like Receptor 7; Toll-Like Receptor 8	2020
Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine. Nucleic acids research, 2020, 05-21, Volume: 48, Issue:9 Topics: Adenine; Base Pairing; Deoxyguanine Nucleotides; DNA Polymerase beta; DNA-Directed DNA Polymerase; Humans; Kinetics; Mutagenesis; Mutation; Thymine Nucleotides	2020
Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4. The Biochemical journal, 2020, 08-14, Volume: 477, Issue:15 Topics: Adenine; Archaeal Proteins; Base Pairing; Catalytic Domain; DNA Polymerase beta; DNA Repair; DNA, Bacterial; Guanosine Triphosphate; Mutagens; Protein Conformation; Sulfolobus solfataricus; Thiamine	2020
Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4. The Biochemical journal, 2021, 05-14, Volume: 478, Issue:9 Topics: Adenine; Amino Acid Sequence; Archaeal Proteins; Binding Sites; Cloning, Molecular; Crystallography, X-Ray; DNA Polymerase beta; Escherichia coli; Gene Expression; Genetic Vectors; Guanine; Kinetics; Models, Molecular; Nucleic Acid Conformation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Sulfolobus solfataricus; Thermodynamics	2021