Compounds > adenine

adenine and 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine

adenine has been researched along with 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine in 54 studies

Research

Studies (54)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's39 (72.22)24.3611
2020's15 (27.78)2.80

Authors

AuthorsStudies
Atkins, C; Axten, JM; Feng, Y; Gampe, RT; Goetz, A; Grant, SW; Hassell, AM; Heerding, DA; Hong, X; Kahler, KM; Kumar, R; Li, WH; Liu, Q; Medina, JR; Mencken, T; Minthorn, E; Rabindran, S; Romeril, SP; Shewchuk, LM; Shu, A; Sigethy, SD; Stanley, T; Taylor, JD; Tomberlin, GH1
Hoozemans, JJ; Scheper, W1
Axten, JM; Barrett, DA; Fischer, PM; Halliday, M; Mallucci, GR; Molloy, C; Moreno, JA; Ortori, CA; Radford, H; Verity, N; Willis, AE1
Jones, B1
Bonini, NM; Finkbeiner, S; Gitler, AD; Kim, HJ; LaDow, ES; Lee, VM; McGurk, L; Raphael, AR; Trojanowski, JQ; Weber, RA1
Halliday, M; Mallucci, GR; Radford, H1
Edry, E; Ounallah-Saad, H; Rosenblum, K; Sharma, V1
Lin, LC; Sibille, E1
Jamison, S; Lin, W; Lin, Y1
Halliday, M; Mallucci, GR; Moreno, JA; Radford, H; Verity, N1
Cao, S; Chen, G; Chen, J; Dixon, B; Gu, C; Li, J; Lin, W; Yan, F; Yu, X1
Chen, TC; Chen, YC; Chien, CC; Wu, MS1
Abiraman, K; Benveniste, EN; Gibson, SA; Guthrie, LN; McFarland, BC; Meares, GP; Plyler, ES; Rajbhandari, R; Rowse, AL; Sprenkle, NT1
Chen, YC; Chien, CC; Chiu, WT; Wu, WS1
Cavener, DR; Henninger, K; McGrath, BC; Zhu, S1
Abhishek, K; Das, P; Das, S; Dikhit, MR; Ghosh, AK; Kumar, A; Mandal, A; Purkait, B; Saini, S; Sardar, AH; Singh, R; Verma, S1
Li, Z; Stork, C; Vuong, JK; Zhang, M; Zheng, S1
Jiang, X; Qiu, S; Wei, Y; Zhang, S; Zhang, T; Zhang, Z; Zhou, X1
Dolinay, T; Himes, BE; Lawrence, GG; Margulies, SS; Shumyatcher, M1
Han, F; Shi, Y; Wen, L; Xiao, B1
Cabral-Miranda, F; Duran-Aniotz, C; Hetz, C; Martínez, G; Vivar, JP1
Augustyns, K; Bertrand, MJM; Delvaeye, T; Nerinckx, W; Roelandt, R; Rojas-Rivera, D; Vandenabeele, P1
Chang, SH; Chen, YJ; Chung, KC; Hsieh, CW; Huang, SW; Kao, JK; Shieh, JJ; Wang, ST; Wu, CY1
Bai, H; Shi, L; Wang, XY; Yang, YX; Zhang, XC; Zhang, XH; Zhou, SF; Zhou, ZW1
Adamson, P; Aguila, M; Athanasiou, D; Bellingham, J; Cheetham, ME; Kanuga, N1
Bai, J; Chen, M; Gao, N; Jiang, L; Liu, X; Qiu, T; Sun, X; Wu, W; Yang, G; Yang, L; Yao, X; Zhang, Q1
Barrera, I; Ben Tabou de Leon, S; Chakraborty, D; Edry, E; Hleihil, M; Kaphzan, H; Kolatt Chandran, S; Ounallah-Saad, H; Rosenblum, K; Sharma, V; Sood, R1
Jang, JY; Jung, HS; Kim, MJ; Kim, MN; Kim, SW; Lee, H; Min, SH; Park, KS; Shin, SY1
Beckelman, BC; Galli, LD; Kasica, NP; Ma, T; Ryazanov, AG; Yang, W; Zhou, X; Zimmermann, HR1
Axten, JM; Castillo, V; Hetz, C; Hoozemans, JJM; López, N; Mercado, G; Sardi, SP; Soto, P1
Bernhart, E; Depaoli, MR; Fauler, G; Goeritzer, M; Gottschalk, B; Graier, WF; Hammer, A; Kogelnik, N; Malle, E; Malli, R; Nusshold, C; Plastira, I; Prasch, J; Reicher, H; Sattler, W1
Axten, JM; Capone, V; Chiesa, R; Comerio, L; Corbelli, A; Fiordaliso, F; Grande, V; Laping, NJ; Masone, A; Ornaghi, F; Restelli, E; Sallese, M; Tolomeo, D1
Bollo, M; Cambiasso, MJ; Feliziani, C; Lopez, PH; Virgolini, MJ1
Ham, DS; Jung, HS; Kim, JW; Kim, MJ; Kim, MN; Min, SH; Park, KS; Yoon, KH1
Du, Y; Gong, H; Osakue, D; Wang, Y; Xia, X; Yang, E; Zhou, Y1
Gonzalez, C; Hetz, C; Lopez, N; Martinez, A1
Chevet, E; Chintha, C; Darawshi, O; Eriksson, LA; Huber, M; Mahameed, M; Obiedat, A; Samali, A; Schubert, T; Tirosh, B; Tommy, WS; Wilhelm, T1
Zito, E1
Ding, Z; Guo, Y; Kong, L; Li, S; Ou, Y; Pan, Z; Tang, Y; Wan, J; Wang, Q; Wang, T; Wu, Y; Xin, X; Yang, Z; Yu, Q; Zhang, Y; Zhu, L1
Fu, H; Huang, H; Li, Y; Liao, P; Lu, Q; Mao, G; Qin, H; Wei, Z; Wu, Y; Zhang, Y1
Glasebach, H; Hans, F; Kahle, PJ1
Chen, CH; Chou, CT; Hung, SC; Ko, YA; Lin, KI; Liu, CH; Liu, FC; Tsai, WC; Tzeng, IS; Wang, CC; Wu, YT; Yang, SY; Yue, CT1
Aragón, T; Arrasate, M; Baltanás, A; Bugallo, R; Ferrero, R; Larrea, L; Marlin, E; Toledo, E; Vinueza-Gavilanes, R1
Alasiri, G; Intuyod, K; Jiramongkol, Y; Ke, HL; Lam, EW; Mahmud, Z; Trakansuebkul, S1
Ito, H; Le, MN; Morimoto, K; Takaki, M; Tanaka, T; Yamashita, Y; Yoshida, LM1
Bunik, V; Che, L; Fan, B; Li, GY; Pan, YR; Song, JY; Wang, Y; Zhang, SM1
Guo, F; Guo, J; Guo, Z; Lin, J; Ren, R; Sun, K; Wang, G; Xu, T; Yao, X1
Bijonowski, BM; Grant, SC; Jeske, R; Li, Y; Yuan, X1
Cao, Z; Duan, T; Hu, C; Hu, X; Liu, J; Wu, Z1
Carlos, JAEG; Costa-Lotufo, LV; Leitão, A; Lima, K; Machado-Neto, JA1
Au-Yeung, RK; Cai, JP; Chan, JF; Chu, H; Hou, Y; Hu, B; Huang, X; Jin, DY; Kok, KH; Li, C; Perlman, S; Poon, VK; Shuai, H; Wang, Y; Wen, L; Wong, BH; Wong, KK; Yang, D; Yeung, ML; Yoon, C; Yuan, S; Yuen, KY; Zhang, X; Zhao, X; Zhou, J1
Dudley, SC; Feng, F; Gu, L; Kang, GJ; Karnopp, C; Liu, H; Liu, M; Parthiban, P; Shi, G; Tolkacheva, EG; Zhou, A1
Ah-Son, N; Broggini, M; Darini, C; Ghaddar, N; Hatzoglou, M; Johnson, M; Kazimierczak, U; Koromilas, AE; Krishnamoorthy, J; Larsson, O; Le Quesne, J; Mann, KK; Officer, L; Popper, H; Teodósio, A; Topisirovic, I; van Hoef, V; Wang, S; Woodvine, B1
Bi, Y; Chen, J; Du, X; Mou, Y; Wu, Y; Xu, L; Xu, Y1

Reviews

4 review(s) available for adenine and 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine

ArticleYear
Prions: generation and spread versus neurotoxicity.
    The Journal of biological chemistry, 2014, Jul-18, Volume: 289, Issue:29

    Topics: Adenine; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; eIF-2 Kinase; Humans; Indoles; Neurodegenerative Diseases; Parkinson Disease; Prion Diseases; Prions; Protein Conformation; Protein Kinase Inhibitors; tau Proteins; Tauopathies; Unfolded Protein Response

2014
Endoplasmic reticulum proteostasis impairment in aging.
    Aging cell, 2017, Volume: 16, Issue:4

    Topics: Adenine; Aging; Animals; Brain; Caenorhabditis elegans; Drosophila melanogaster; Endoplasmic Reticulum Stress; Guanabenz; Humans; Indoles; Neurodegenerative Diseases; Neurons; Protective Agents; Proteome; Proteostasis; Proteostasis Deficiencies; Saccharomyces cerevisiae; Unfolded Protein Response

2017
Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease.
    Biology of the cell, 2019, Volume: 111, Issue:6

    Topics: Adenine; Adrenergic alpha-2 Receptor Agonists; Animals; Disease Models, Animal; Endoplasmic Reticulum Stress; Genetic Therapy; Humans; Indoles; Mice; Mice, Transgenic; Parkinson Disease; Signal Transduction; Unfolded Protein Response

2019
Targeting ER stress/ER stress response in myopathies.
    Redox biology, 2019, Volume: 26

    Topics: Activating Transcription Factor 6; Adenine; Aldehydes; Animals; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Endoribonucleases; Gene Expression Regulation; Humans; Indoles; Mice; Mitochondria; Molecular Targeted Therapy; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Diseases; Phenylbutyrates; Protein Serine-Threonine Kinases; Signal Transduction; Sulfonamides; Thiophenes

2019

Other Studies

50 other study(ies) available for adenine and 7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1h-indol-5-yl)-7h-pyrrolo(2,3-d)pyrimidin-4-amine

ArticleYear
Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
    Journal of medicinal chemistry, 2012, Aug-23, Volume: 55, Issue:16

    Topics: Adenine; Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Crystallography, X-Ray; Dogs; Drug Screening Assays, Antitumor; eIF-2 Kinase; Female; Humans; Indoles; Male; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Phosphorylation; Protein Conformation; Pyrimidines; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Transplantation, Heterologous

2012
A new PERKspective on neurodegeneration.
    Science translational medicine, 2013, Oct-09, Volume: 5, Issue:206

    Topics: Adenine; Alzheimer Disease; Animals; eIF-2 Kinase; Female; Humans; Indoles; Male; Memory Disorders; Nerve Degeneration; Neuronal Plasticity; Prion Diseases; Unfolded Protein Response

2013
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.
    Science translational medicine, 2013, Oct-09, Volume: 5, Issue:206

    Topics: Adenine; Administration, Oral; Animals; Blood-Brain Barrier; Brain; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Indoles; Mice; Nerve Degeneration; Neuroprotective Agents; Phosphorylation; Prion Diseases; Prions; Protein Biosynthesis; Synapses; Unfolded Protein Response

2013
Neurodegenerative disease: Neurodegeneration halted with oral therapy in mice.
    Nature reviews. Neurology, 2013, Volume: 9, Issue:12

    Topics: Adenine; Animals; Indoles; Nerve Degeneration; Prion Diseases; Unfolded Protein Response

2013
Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models.
    Nature genetics, 2014, Volume: 46, Issue:2

    Topics: Adenine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Ataxins; DNA-Binding Proteins; Drosophila melanogaster; Eukaryotic Initiation Factor-2; Gene Ontology; High-Throughput Screening Assays; Humans; Immunoblotting; Immunohistochemistry; Indoles; Luminescent Proteins; Motor Neurons; Nerve Tissue Proteins; Phosphorylation; Poly(A)-Binding Proteins; Red Fluorescent Protein; Retina; RNA Interference; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Small Molecule Libraries; Spinal Cord

2014
Genetic or pharmacological reduction of PERK enhances cortical-dependent taste learning.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Oct-29, Volume: 34, Issue:44

    Topics: Adenine; Animals; Avoidance Learning; Cerebral Cortex; eIF-2 Kinase; Eukaryotic Initiation Factor-2; Indoles; Learning; Mice; Phosphorylation; Rats; RNA, Small Interfering; Taste

2014
Somatostatin, neuronal vulnerability and behavioral emotionality.
    Molecular psychiatry, 2015, Volume: 20, Issue:3

    Topics: Adenine; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Eukaryotic Initiation Factor-2; Female; Gene Expression Regulation; Glutamate Decarboxylase; Green Fluorescent Proteins; Gyrus Cinguli; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mood Disorders; Neurons; Signal Transduction; Somatostatin; Stress, Psychological; Transcriptome

2015
Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Adenine; Cell Line, Tumor; Cell Movement; Cerebellar Neoplasms; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Humans; Indoles; Medulloblastoma; Protein Kinase Inhibitors; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2

2015
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
    Acta neuropathologica, 2015, Volume: 130, Issue:5

    Topics: Adenine; Animals; Atrophy; Brain; Disease Models, Animal; eIF-2 Kinase; Female; Frontotemporal Dementia; Humans; Indoles; Male; Mice, Transgenic; Motor Activity; Mutation; Neurons; Neuroprotective Agents; Organ Size; Phosphorylation; Protein Kinase Inhibitors; Signal Transduction; tau Proteins

2015
Pharmacological Inhibition of PERK Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats Through the Activation of Akt.
    Molecular neurobiology, 2017, Volume: 54, Issue:3

    Topics: Adenine; Animals; Brain Injuries; eIF-2 Kinase; Heterocyclic Compounds, 3-Ring; Indoles; Male; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage

2017
Evodiamine from Evodia rutaecarpa induces apoptosis via activation of JNK and PERK in human ovarian cancer cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2016, Jan-15, Volume: 23, Issue:1

    Topics: Adenine; Anthracenes; Apoptosis; Caspase 3; Cell Line, Tumor; eIF-2 Kinase; Evodia; Female; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Ovarian Neoplasms; Poly(ADP-ribose) Polymerases; Quinazolines; Signal Transduction; Structure-Activity Relationship

2016
Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses.
    The Journal of biological chemistry, 2016, 07-22, Volume: 291, Issue:30

    Topics: Adenine; Animals; Astrocytes; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Indoles; Inflammation; Macrophages; Mice; Mice, Knockout; Microglia; Phosphorylation; Signal Transduction; T-Lymphocytes

2016
Protein Kinase RNA-Like Endoplasmic Reticulum Kinase-Mediated Bcl-2 Protein Phosphorylation Contributes to Evodiamine-Induced Apoptosis of Human Renal Cell Carcinoma Cells.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Adenine; Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; eIF-2 Kinase; Gene Expression Regulation; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Kidney Neoplasms; Male; Membrane Potential, Mitochondrial; Mice, Nude; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays

2016
PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Adenine; Animals; Blotting, Western; eIF-2 Kinase; Extinction, Psychological; Indoles; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Prosencephalon

2016
Phosphorylation of Translation Initiation Factor 2-Alpha in Leishmania donovani under Stress Is Necessary for Parasite Survival.
    Molecular and cellular biology, 2017, 01-01, Volume: 37, Issue:1

    Topics: Adenine; Animals; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Hot Temperature; Hydrogen Peroxide; Hydrogen-Ion Concentration; Indoles; Leishmania donovani; Leishmaniasis; Life Cycle Stages; Mice; Oxidative Stress; Phosphorylation; Protozoan Proteins; Stress, Physiological

2017
Inhibition of nonsense-mediated RNA decay by ER stress.
    RNA (New York, N.Y.), 2017, Volume: 23, Issue:3

    Topics: Adenine; Alternative Splicing; Animals; Carrier Proteins; Cell Line, Tumor; Codon, Nonsense; Disks Large Homolog 4 Protein; DNA-Binding Proteins; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Guanylate Kinases; Heterogeneous-Nuclear Ribonucleoproteins; High-Throughput Screening Assays; Indoles; Membrane Proteins; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurons; Polypyrimidine Tract-Binding Protein; Protein Kinase Inhibitors; RNA Stability; RNA-Binding Proteins; Signal Transduction; Thapsigargin

2017
Effects of GSK2606414 on cell proliferation and endoplasmic reticulum stress‑associated gene expression in retinal pigment epithelial cells.
    Molecular medicine reports, 2017, Volume: 15, Issue:5

    Topics: Activating Transcription Factor 4; Adenine; Apoptosis; CCAAT-Enhancer-Binding Proteins; Cell Proliferation; Endoplasmic Reticulum Stress; Epithelial Cells; Eukaryotic Initiation Factor-2; Gene Expression; Humans; Indoles; Phosphorylation; Retinal Pigment Epithelium; RNA, Messenger; Signal Transduction; Thapsigargin; Transcription Factor CHOP; Vascular Endothelial Growth Factor A

2017
Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.
    American journal of respiratory cell and molecular biology, 2017, Volume: 57, Issue:2

    Topics: Activating Transcription Factor 4; Adenine; Alveolar Epithelial Cells; Animals; Cell Death; Cell Membrane Permeability; Cells, Cultured; Cytokines; Drug Evaluation, Preclinical; eIF-2 Kinase; Enzyme Activation; Gene Expression Regulation; Indoles; Protease Inhibitors; Pulmonary Edema; Rats; Rats, Sprague-Dawley; RNA Interference; Signal Transduction; Stress, Mechanical; Stress, Physiological; Transcription Factor CHOP; Unfolded Protein Response; Ventilator-Induced Lung Injury

2017
PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons.
    Apoptosis : an international journal on programmed cell death, 2017, Volume: 22, Issue:6

    Topics: Activating Transcription Factor 4; Adenine; Animals; Caspase 12; Cell Nucleus; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Indoles; Male; Maze Learning; Memory; Neurons; Phosphorylation; Prefrontal Cortex; Rats, Wistar; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcription Factor CHOP; Up-Regulation

2017
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157.
    Cell death and differentiation, 2017, Volume: 24, Issue:6

    Topics: Adenine; Animals; Apoptosis; Cell Line; eIF-2 Kinase; Indoles; Mice; Receptor-Interacting Protein Serine-Threonine Kinases; Unfolded Protein Response

2017
Imiquimod-induced autophagy is regulated by ER stress-mediated PKR activation in cancer cells.
    Journal of dermatological science, 2017, Volume: 87, Issue:2

    Topics: Adenine; Aminoquinolines; Apoptosis; Autophagy; Cell Line, Tumor; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Fluorescent Antibody Technique; Heat-Shock Proteins; Humans; Imiquimod; Indoles; Microtubule-Associated Proteins; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sequestosome-1 Protein; Toll-Like Receptor 7

2017
The combination of digoxin and GSK2606414 exerts synergistic anticancer activity against leukemia in vitro and in vivo.
    BioFactors (Oxford, England), 2017, Volume: 43, Issue:6

    Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Cell Survival; Digoxin; Drug Combinations; Drug Synergism; Female; G2 Phase Cell Cycle Checkpoints; Humans; Indoles; K562 Cells; Leukemia, Erythroblastic, Acute; Mice; Mice, Nude; Proto-Oncogene Proteins c-akt; THP-1 Cells; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays

2017
The role of the ER stress-response protein PERK in rhodopsin retinitis pigmentosa.
    Human molecular genetics, 2017, 12-15, Volume: 26, Issue:24

    Topics: Adenine; Animals; Cell Line, Transformed; Cell Line, Tumor; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Humans; Indoles; Protein Folding; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Retinal Rod Photoreceptor Cells; Retinitis Pigmentosa; Sensory Rhodopsins; Stress, Physiological; Unfolded Protein Response

2017
Pancreatic islet-autonomous effect of arsenic on insulin secretion through endoplasmic reticulum stress-autophagy pathway.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018, Volume: 111

    Topics: Adenine; Animals; Arsenic Trioxide; Arsenicals; Autophagy; Biomarkers; eIF-2 Kinase; Endoplasmic Reticulum Stress; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Oxides; Specific Pathogen-Free Organisms; Tissue Culture Techniques

2018
Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018, 01-17, Volume: 38, Issue:3

    Topics: Adenine; Aging; Animals; Cognition; Cognitive Dysfunction; eIF-2 Kinase; Enzyme Inhibitors; Hippocampus; Indoles; Learning; Male; Memory; Mice; Pyramidal Cells

2018
Attenuation of PERK enhances glucose-stimulated insulin secretion in islets.
    The Journal of endocrinology, 2018, Volume: 236, Issue:3

    Topics: Adenine; Animals; Calcium; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Female; Gene Expression; Glucose; Heat-Shock Proteins; Humans; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phosphorylation

2018
Genetic removal of eIF2α kinase PERK in mice enables hippocampal L-LTP independent of mTORC1 activity.
    Journal of neurochemistry, 2018, Volume: 146, Issue:2

    Topics: Adenine; Animals; Anisomycin; Biophysics; Electric Stimulation; Enzyme Inhibitors; Female; Gene Expression Regulation; Hippocampus; Immunosuppressive Agents; In Vitro Techniques; Indoles; Long-Term Potentiation; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Phosphorylation; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Sirolimus

2018
Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease.
    Neurobiology of disease, 2018, Volume: 112

    Topics: Adenine; Animals; Disease Models, Animal; eIF-2 Kinase; Female; Humans; Indoles; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Signal Transduction

2018
2-Chlorohexadecanoic acid induces ER stress and mitochondrial dysfunction in brain microvascular endothelial cells.
    Redox biology, 2018, Volume: 15

    Topics: Adenine; Apoptosis; Blood-Brain Barrier; Brain; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum Stress; Endothelial Cells; Humans; Indoles; Interleukin-8; Leukocytes; Membrane Potential, Mitochondrial; Mitochondria; Palmitic Acids; Peroxidase

2018
PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome.
    Human molecular genetics, 2018, 07-15, Volume: 27, Issue:14

    Topics: Adenine; Animals; Cerebellum; Disease Models, Animal; eIF-2 Kinase; Endoplasmic Reticulum; Guanine Nucleotide Exchange Factors; Heterozygote; HSP70 Heat-Shock Proteins; Humans; Indoles; Loss of Function Mutation; Mice; Motor Activity; Nerve Degeneration; Protein Folding; Purkinje Cells; Spinocerebellar Degenerations; Unfolded Protein Response

2018
Neurite atrophy and apoptosis mediated by PERK signaling after accumulation of GM2-ganglioside.
    Biochimica et biophysica acta. Molecular cell research, 2019, Volume: 1866, Issue:2

    Topics: Adenine; Animals; Apoptosis; Atrophy; Cell Line, Tumor; eIF-2 Kinase; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; G(M2) Ganglioside; Gangliosidoses, GM2; Indoles; Mice; Neurites; Neurodegenerative Diseases; Neurons; Signal Transduction; Transcription Factor CHOP; Unfolded Protein Response

2019
Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes.
    Metabolism: clinical and experimental, 2019, Volume: 97

    Topics: Adenine; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; eIF-2 Kinase; Glucose; Hyperglycemia; Indoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Palmitates; Sulfonylurea Compounds

2019
Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway.
    Investigative ophthalmology & visual science, 2019, 01-02, Volume: 60, Issue:1

    Topics: Adenine; Anti-Bacterial Agents; Apoptosis; Biomarkers; Blotting, Western; Brefeldin A; Cell Survival; Cinnamates; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique, Indirect; Humans; Indoles; Microscopy, Electron, Transmission; Real-Time Polymerase Chain Reaction; Stem Cells; Thapsigargin; Thiourea; Trabecular Meshwork; Tunicamycin; Unfolded Protein Response

2019
The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors.
    Cell death & disease, 2019, 04-01, Volume: 10, Issue:4

    Topics: Adenine; Cell Survival; eIF-2 Kinase; Endocytosis; HEK293 Cells; Hep G2 Cells; Humans; Imidazoles; Indoles; Kinetics; Lysosomes; Naphthalenes; Proto-Oncogene Proteins c-kit; Pyrazines; Unfolded Protein Response

2019
Japanese Encephalitis Virus Induces Apoptosis and Encephalitis by Activating the PERK Pathway.
    Journal of virology, 2019, 09-01, Volume: 93, Issue:17

    Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Binding Sites; Cell Line; Disease Models, Animal; eIF-2 Kinase; Encephalitis Virus, Japanese; Encephalitis, Japanese; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Indoles; Mice; Neurons; Protein Multimerization; Signal Transduction; Transcription Factor CHOP; Viral Nonstructural Proteins

2019
Hes1 Knockdown Exacerbates Ischemic Stroke Following tMCAO by Increasing ER Stress-Dependent Apoptosis via the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
    Neuroscience bulletin, 2020, Volume: 36, Issue:2

    Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Brain; eIF-2 Kinase; Endoplasmic Reticulum Stress; Eukaryotic Initiation Factor-2; Indoles; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Signal Transduction; Stroke; Transcription Factor CHOP; Transcription Factor HES-1

2020
Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules.
    The Journal of biological chemistry, 2020, 01-17, Volume: 295, Issue:3

    Topics: Acetylcysteine; Adenine; Amyotrophic Lateral Sclerosis; DNA-Binding Proteins; Frontotemporal Dementia; Glycogen Synthase Kinase 3 beta; Heat-Shock Proteins; HEK293 Cells; Humans; Indoles; Mutation; Osmotic Pressure; Oxidative Stress; Protein Aggregation, Pathological; Protein Transport; Signal Transduction; Solubility; Sorbitol; Ubiquitination

2020
Aberrant distribution and function of plasmacytoid dendritic cells in patients with ankylosing spondylitis are associated with unfolded protein response.
    The Kaohsiung journal of medical sciences, 2020, Volume: 36, Issue:6

    Topics: Adenine; Bone Marrow Cells; Case-Control Studies; Cell Count; Chemokine CCL20; Dendritic Cells; eIF-2 Kinase; Hip; HLA-B27 Antigen; Humans; Immunophenotyping; Indoles; Interleukin-23; Interleukin-6; Protein Kinase Inhibitors; Receptors, CCR6; Severity of Illness Index; Signal Transduction; Spondylitis, Ankylosing; Synovial Membrane; Tumor Necrosis Factor-alpha; Unfolded Protein Response

2020
Fine tuning of the unfolded protein response by ISRIB improves neuronal survival in a model of amyotrophic lateral sclerosis.
    Cell death & disease, 2020, 05-26, Volume: 11, Issue:5

    Topics: Acetamides; Adenine; Amyotrophic Lateral Sclerosis; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclohexylamines; eIF-2 Kinase; Endoplasmic Reticulum Stress; HEK293 Cells; HeLa Cells; Humans; Indoles; Mice; Models, Biological; Mutation; Neurons; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase; Survival Analysis; Unfolded Protein Response

2020
Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival.
    Molecular and cellular endocrinology, 2020, 09-15, Volume: 515

    Topics: Adenine; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm; eIF-2 Kinase; Endoplasmic Reticulum Stress; Epirubicin; Female; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Humans; Indoles; MAP Kinase Signaling System; MCF-7 Cells; Paclitaxel; Protein Serine-Threonine Kinases; Signal Transduction

2020
Cigarette smoke induces endoplasmic reticulum stress and suppresses efferocytosis through the activation of RhoA.
    Scientific reports, 2020, 07-28, Volume: 10, Issue:1

    Topics: Adenine; Animals; Cell Line; Cigarette Smoking; eIF-2 Kinase; Endoplasmic Reticulum Stress; Enzyme Activation; Eukaryotic Initiation Factor-2; Female; Indoles; Macrophages; Mice; Mice, Inbred ICR; Models, Biological; Phagocytosis; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Taurochenodeoxycholic Acid; Tunicamycin

2020
Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury.
    Aging, 2020, 08-28, Volume: 12, Issue:16

    Topics: Acetylcysteine; Adenine; Animals; Antioxidants; Autophagy; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum Stress; Humans; Indoles; Light; Male; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Photoreceptor Cells, Vertebrate; Retinal Pigment Epithelium

2020
PERK controls bone homeostasis through the regulation of osteoclast differentiation and function.
    Cell death & disease, 2020, 10-13, Volume: 11, Issue:10

    Topics: Adenine; Animals; Bone and Bones; Cell Differentiation; Down-Regulation; eIF-2 Kinase; Endoplasmic Reticulum Stress; Female; Homeostasis; Humans; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoclasts; Random Allocation; RANK Ligand; Thapsigargin

2020
Cyclical aggregation extends in vitro expansion potential of human mesenchymal stem cells.
    Scientific reports, 2020, 11-24, Volume: 10, Issue:1

    Topics: Adenine; Cell Aggregation; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cellular Senescence; Cinnamates; Humans; Indoles; Mesenchymal Stem Cells; Surface Properties; Thiourea

2020
1,25-(OH)2D3 protects pancreatic beta cells against H2O2-induced apoptosis through inhibiting the PERK-ATF4-CHOP pathway.
    Acta biochimica et biophysica Sinica, 2021, Jan-12, Volume: 53, Issue:1

    Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Calcitriol; Cell Line; Cell Survival; Diabetes Mellitus, Type 1; eIF-2 Kinase; Endoplasmic Reticulum Stress; Hydrogen Peroxide; Indoles; Insulin-Secreting Cells; Mice; Protective Agents; Signal Transduction; Transcription Factor CHOP

2021
AD80, a multikinase inhibitor, exhibits antineoplastic effects in acute leukemia cellular models targeting the PI3K/STMN1 axis.
    Investigational new drugs, 2021, Volume: 39, Issue:4

    Topics: Adenine; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Heterocyclic Compounds, 4 or More Rings; Humans; Indoles; Jurkat Cells; Leukemia, Myeloid, Acute; Phenylurea Compounds; Phosphatidylinositol 3-Kinase; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; RNA, Messenger; Stathmin; Time Factors; U937 Cells

2021
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity.
    Science advances, 2021, Volume: 7, Issue:25

    Topics: Adenine; Angiotensin-Converting Enzyme 2; Animals; Antiviral Agents; Apoptosis; Cell Line; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Dipeptidyl Peptidase 4; eIF-2 Kinase; Epithelial Cells; Female; Humans; Indoles; Lung; Male; Mice, Transgenic

2021
Inhibition of the unfolded protein response reduces arrhythmia risk after myocardial infarction.
    The Journal of clinical investigation, 2021, 09-15, Volume: 131, Issue:18

    Topics: Adenine; Animals; Arrhythmias, Cardiac; Down-Regulation; eIF-2 Kinase; Female; Heart Disease Risk Factors; Humans; Indoles; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Cardiovascular; Myocardial Infarction; Protein Kinase Inhibitors; Unfolded Protein Response

2021
The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer.
    Nature communications, 2021, 07-30, Volume: 12, Issue:1

    Topics: Adenine; Adenocarcinoma; Animals; Carcinogenesis; Cell Line, Tumor; Dual Specificity Phosphatase 6; Eukaryotic Initiation Factor-2; Female; Humans; Indoles; Kaplan-Meier Estimate; Lung Neoplasms; Male; Mice, Nude; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins p21(ras); Stress, Physiological; Xenograft Model Antitumor Assays

2021
Suppression of CHOP Reduces Neuronal Apoptosis and Rescues Cognitive Impairment Induced by Intermittent Hypoxia by Inhibiting Bax and Bak Activation.
    Neural plasticity, 2021, Volume: 2021

    Topics: Adenine; Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Cognitive Dysfunction; Hypoxia; Indoles; Male; Mice; Mice, Inbred C57BL; Neurons; PC12 Cells; Rats; Transcription Factor CHOP

2021