adenine has been researched along with 3-methyladenine in 1217 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 64 (5.26) | 18.7374 |
| 1990's | 66 (5.42) | 18.2507 |
| 2000's | 146 (12.00) | 29.6817 |
| 2010's | 828 (68.04) | 24.3611 |
| 2020's | 113 (9.29) | 2.80 |
| Authors | Studies |
|---|---|
| Balavoine, S; Feldmann, G; Lardeux, B; Rogier, E | 1 |
| Antoccia, A; Basu, AK; Dosanjh, MK; Fraenkel-Conrat, H; Gallagher, PE; Kuśmierek, JT; Qiu, ZH; Rydberg, B; Singer, B | 1 |
| Heikoop, JC; Just, WW; Meijer, AJ; Strijland, A; Tager, JM; van den Berg, M; Weijers, PJ | 1 |
| Czaika, G; Mamet-Bratley, MD | 1 |
| Sandvig, K; van Deurs, B | 1 |
| Laval, J; O'Connor, TR | 1 |
| Hendil, KB; Lauridsen, AM; Seglen, PO | 1 |
| Bansal, DD; MacGregor, RR | 3 |
| Chaudhuri, I; Essigmann, JM | 1 |
| Ciechanover, A; Gropper, R; Schwartz, AL | 1 |
| Ahnström, G; Eizirik, DL; Sandler, S; Welsh, M | 1 |
| Bearer, CF; Brandt, RA; Ciechanover, A; Elias, S; Gropper, R; Mayer, A; Schwartz, AL | 1 |
| Friesen, MD; Garren, L; Prévost, V; Shuker, DE | 1 |
| Cushnir, JR; Farmer, PB; Lamb, JH; Parry, A | 1 |
| Correa, P; Glogowski, J; Stillwell, WG; Tannenbaum, SR; Wishnok, JS; Xu, HX | 1 |
| Chakravarti, D; Ibeanu, GC; Mitra, S; Tano, K | 1 |
| Bartsch, H; Ohshima, H; Shuker, DE | 1 |
| Hinton, DA; MacGregor, RR | 1 |
| Correa, P; Glogowski, J; Montes, G; Stillwell, WG; Tannenbaum, SR; Wishnok, JS; Xu, HX; Zavala, D | 1 |
| Bartsch, H; Calmels, S; Ohshima, H; Pignatelli, B; Shuker, DE | 1 |
| Bartsch, H; Pastorelli, R; Prevost, V; Shuker, DE; Stillwell, WG; Tannenbaum, SR; Trudel, LJ | 1 |
| Drosdziok, W; Eberle, G; Glüsenkamp, KH; Rajewsky, MF | 1 |
| Berdal, KG; Bjelland, S; Bjørås, M; Seeberg, E | 1 |
| Punnonen, EL; Reunanen, H | 1 |
| Farber, JL; Kyle, ME; Sakaida, I | 1 |
| Gordon, PB; Kisen, GO; Kovács, AL; Seglen, PO | 1 |
| Habraken, Y; Ludlum, DB | 1 |
| Ballard, FJ; Hopgood, MF; Knowles, SE | 1 |
| Farmer, PB; Mandel, HG; Martin, J; Straw, JA | 1 |
| Gordon, PB; Høyvik, H; Meijer, AJ; Plomp, PJ; Seglen, PO | 1 |
| Hanawalt, PC; Scicchitano, DA | 1 |
| Schwarze, PE; Seglen, PO | 2 |
| Hanski, C; Lawley, PD | 1 |
| Ballard, FJ; Chandler, CS | 1 |
| Boiteux, S; Costa de Oliveira, R; Laval, J | 1 |
| Farmer, PB; Shuker, DE | 1 |
| pdessey, R | 1 |
| Caro, LH; Kerkhof, C; Meijer, AJ; Plomp, PJ; Wolvetang, EJ | 1 |
| Lawrence, CW; Nisson, PE | 1 |
| Murray, V | 1 |
| Bailey, E; Farmer, PB; Lamb, J; Parry, A; Shuker, DE | 1 |
| Backendorf, C; Kaina, B; Thielmann, HW; Van de Putte, P; Van Zeeland, AA | 1 |
| Bailey, E; Farmer, PB; Shuker, DE | 1 |
| D'Ambrosio, SM; Wani, AA | 1 |
| Gordon, PB; Høyvik, H; Seglen, PO | 1 |
| Kirwin, P; Mayer, RJ; O'Hare, M; Razooki-Hasan, H; White, DA; Wilde, C | 1 |
| Linn, S; Samson, L | 1 |
| Bernstein, PL; Etlinger, JD; Ludemann, R; Zeman, RJ | 1 |
| Ballard, FJ | 1 |
| Wakeland, JR; Wildenthal, K | 1 |
| Bertaux, O; N'Guyen Công, H; Valencia, R | 1 |
| Bernstein, P; Etlinger, JD; Kameyama, T; Matsumoto, K; Zeman, RJ | 1 |
| Gordon, PB; Høyvik, H; Seglen, PO; Tolleshaug, H | 2 |
| Colaço, CB; Harris, G; Irving, W; Lawley, PD; Lydyard, PM; Phillips, E; Roitt, IM | 1 |
| Helland, DE; Kleppe, K; Male, R | 1 |
| Seglen, PO; Solheim, AE | 1 |
| Gordon, PB; Seglen, PO; Tolleshaug, H | 2 |
| Briscoe, WT; Cotter, LE | 1 |
| Seglen, PO; Tolleshaug, H | 1 |
| Boiteux, S; Huisman, O; Laval, J | 1 |
| Cathcart, R; Goldthwait, DA | 1 |
| Goldthwait, DA; Heller, E; Price, JA | 1 |
| Bresil, H; Cooper, DP; Margison, GP; Montesano, R; O'Connor, PJ; Planche-Martel, G; Smith, RA | 1 |
| Huang, SS; Pontzer, NJ; Shaikh, B | 1 |
| Dybedal, MA; Munthe-Kaas, AC; Seglen, PO | 1 |
| Ege, T; Reisbig, RR; Rogne, S | 1 |
| Goldthwait, DA; Heller, EP | 1 |
| Gordon, PB; Seglen, PO | 2 |
| Chu, YH; Craig, AW; O'Connor, PJ | 1 |
| Aurich, O; Heindorff, K; Kaina, B | 1 |
| Sklar, RM; Strauss, BS | 1 |
| Alekandrov, VA; Anisimov, VN; Bespalov, VG; Korsakov, MV; Likhachev, AJ; Napalkov, NP; Ovsyannikov, AI; Popovich, IG; Tomatis, L | 1 |
| Margison, GP; Pegg, AE | 1 |
| Evensen, G; Seeberg, E | 1 |
| Goldthwait, DA; Thomas, L; Yang, CH | 1 |
| Hjelmgren, T; Jacobsson, A; Lindahl, T; Olsson, M; Rydberg, B | 1 |
| Barrows, LR; Magee, PN | 1 |
| Kerler, R; Rabes, HM; Rode, G; Wilhelm, R | 1 |
| Brent, TP; Gallagher, PE | 1 |
| Kleppe, K; Male, R; Nes, IF | 1 |
| Carda, B; Small, GD; Sweet, JM | 1 |
| Abanobi, SE; Columbano, A; Mulivor, RA; Rajalakshmi, S; Sarma, DS | 1 |
| Eberle-Adamkiewicz, G; Glüsenkamp, KH; Kirstein, U; Kopplin, A; Nehls, P | 1 |
| Habraken, Y; Laval, F | 1 |
| Mamet-Bratley, MD; Racine, JF; Zhu, Y | 1 |
| Blommaart, EF; Blommaart, PJ; Luiken, JJ; Meijer, AJ; van Woerkom, GM | 1 |
| Scicchitano, DA; Sitaram, A; Wang, W | 1 |
| Marjomäki, VS; Punnonen, EL; Reunanen, H | 1 |
| Bugnoli, M; de Bernard, M; Milia, E; Montecucco, C; Papini, E; Rappuoli, R; Zerial, M | 1 |
| Benneche, T; Birkeland, NK; Bjelland, S; Seeberg, E; Volden, G | 1 |
| Brooks, C; Mitra, S; Roy, R | 1 |
| Dosanjh, MK; Mitra, S; Roy, R; Singer, B | 1 |
| Dash, PK; Moore, AN | 1 |
| Aquilina, G; Bignami, M; Biondo, R; Dogliotti, E | 1 |
| Codogno, P; Houri, JJ; Ogier-Denis, E; Trugnan, G | 1 |
| Glogowski, JA; Leaf, CD; Stillwell, WG; Tannenbaum, SR; Wishnok, JS | 1 |
| Blommaart, PJ; Lamers, WH; Meijer, AJ; Zonneveld, D | 1 |
| Boosalis, MS; Chen, BJ; Deng, Z; Engelward, BP; Samson, LD; Siciliano, MJ | 1 |
| Bartsch, H; Eberle, G; Friesen, MD; Prevost, V; Rajewsky, MF; Shuker, DE | 1 |
| Chen, FX; Church, K; Encell, L; Gold, B; Mehta, P; Shuker, DE; Williams, J | 1 |
| Franekic, J; Tomicic, M | 1 |
| Bjelland, S; Seeberg, E | 1 |
| Blommaart, EF; Krause, U; Meijer, AJ; Schellens, JP; Vreeling-Sindelárová, H | 1 |
| Kondo, K; Makita, T | 1 |
| Aeschlimann, JM; Fay, LB; Gremaud, E; Leaf, CD; Shuker, DE; Steen, C; Turesky, RJ | 1 |
| Bauvy, C; Codogno, P; Houri, JJ; Ogier-Denis, E | 1 |
| Brazil, MI; Stockinger, B; Weiss, S | 1 |
| Bakke, O; Stang, E | 1 |
| Dourmashkin, RR; Jia, L; Kelsey, SM; Newland, AC | 1 |
| Hatch, GM; Ross, TK | 1 |
| Allan, JM; Dreslin, AJ; Engelward, BP; Gold, B; Kelly, JD; Samson, LD; Wu, MM | 1 |
| Dinglay, S; Gold, B; Sedgwick, B | 1 |
| Kusmierek, JT; Laval, J; Tudek, B; Van Zeeland, AA | 1 |
| Holmquist, GP; O'Connor, TR; Ye, N | 1 |
| Dobrzańska, M; Kraszewska, E; Tudek, B | 1 |
| Dunn, WA; Hickson, I; Jasionowski, T; Lenk, SE; Susan, PP | 1 |
| Kobayashi, T; Mangel, WF; Russell, DG; Schaible, UE; Schlesinger, PH; Steinberg, TH | 1 |
| Calléja, F; Jansen, JG; Laval, F; van Zeeland, AA; Vrieling, H | 1 |
| Augusto, O; Hix, S | 1 |
| Abbondandolo, A; Aprile, A; Burns, PA; Chen, FX; Dande, P; Fronza, G; Gold, B; Inga, A; Kelly, JD; Monti, P; Scott, G; Shah, D | 1 |
| Desautels, M; Heal, S | 1 |
| Fletcher, GC; Tolkovsky, AM; Xue, L | 1 |
| Braybrooke, JP; Crawley, JE; Harris, AL; Houlbrook, S; O'Byrne, KJ; Propper, DJ; Shuker, DE; Stratford, IJ; Talbot, DC | 1 |
| Kovacs, AL; Telbisz, A | 1 |
| Memisoglu, A; Samson, L | 1 |
| Engelward, BP; Smith, SA | 1 |
| Borniquel, S; Callejas, S; Gutiérrez, JC; Martín-González, A | 1 |
| Perlmutter, DH; Teckman, JH | 1 |
| Kovács, AL; Kovács, J; Pálfia, Z; Réz, G | 1 |
| O'Brien, PJ; Pourahmad, J; Ross, S | 1 |
| Delohery, T; Domingo, D; Hackett, N; Hollister, T; McMahill, M; Paglin, S; Sphicas, E; Yahalom, J | 1 |
| Bergamini, E; Cavallini, G; Donati, A; Gori, Z; Pollera, M | 1 |
| Dande, P; Fronza, G; Gold, B; Kelly, J; Marky, L; Martinez, J; Ortiz, G; Shah, D; Soto, AM; Tran, H; Zhang, Y | 1 |
| Mezey, E; Potter, JJ; Rennie-Tankersley, L | 1 |
| Arico, S; Bauvy, C; Codogno, P; Gane, P; Ogier-Denis, E | 1 |
| Bohr, VA; Dianov, GL; Nyaga, SG; Souza-Pinto, N; Stevnsner, T; Thybo, T | 1 |
| Komatsu, F; Masuda, T | 1 |
| Colombo, MI; Munafó, DB | 1 |
| Borutaite, V; Tolkovsky, AM; Xue, L | 1 |
| Dardalhon, V; Géminard, C; Reggio, H; Sainte-Marie, J; Vidal, M | 1 |
| Anensen, H; Birkeland, NK; Bjelland, S; Bjørås, M; Klungland, A; Knaevelsrud, I; Kristoffersen, W; Robb, FT | 1 |
| Lee, JK; Sharma, S | 1 |
| Backer, JM; Brachmann, SM; Cooper, J; Eskelinen, EL; Lucocq, JM; Prescott, AR; Tang, X; Wang, L | 1 |
| Engelward, BP; Gold, B; Magnotti, M; Millas, T; Plosky, B; Samson, L; Schlaen, B; Schor, J; Scicchitano, DA | 1 |
| Beugnet, A; Proud, CG; Taylor, PM; Tee, AR | 1 |
| Di-Segni, A; Lupowitz, Z; Pinkas-Kramarski, R; Tal-Or, P | 1 |
| Chau, YP; Chen, JH; Lin, SY; Tai, MH | 1 |
| Brunk, UT; Dalen, H; Eaton, JW; Neuzil, J; Terman, A | 2 |
| Cao, C; Drohat, AC; Jiang, YL; Kwon, K; Stivers, JT | 1 |
| AXELROD, J; DALY, J | 1 |
| Chen, FX; Dande, P; Fronza, G; Gold, B; Settles, S; Shah, D; Varadarajan, S | 1 |
| Denison, MR; Jerome, WG; Mizushima, N; Prentice, E; Yoshimori, T | 1 |
| Germano, IM; Ito, H; Kanzawa, T; Komata, T; Kondo, S; Kondo, Y | 1 |
| Bergmann, M; Holz, FG; Kopitz, J; Schütt, F | 1 |
| Fronza, G; Gold, B | 1 |
| Baizabal, JM; Cárdenas-Aguayo, Mdel C; Covarrubias, L; Salgado, LM; Santa-Olalla, J | 1 |
| Fujita, H; Himeno, M; Hirosako, K; Hirota, Y; Imasato, H; Kuronita, T; Masuyama, N; Nishioka, M; Tanaka, Y; Umeda, A | 1 |
| Inoue, Y; Matsuoka, K; Moriyasu, Y; Takatsuka, C | 1 |
| Campomenosi, P; Ciribilli, Y; Fronza, G; Gold, B; Iannone, R; Menichini, P; Monti, P; Shah, D; Varadarajan, S | 1 |
| Gold, B; Kisby, GE; Lesselroth, H; Olivas, A; Samson, L; Tanaka, K; Turker, MS | 1 |
| Barker, PA; Bouchard, RJ; Chu, CT; Florez-McClure, ML; Heidenreich, KA; Laessig, TA; Le, SS; Linseman, DA | 1 |
| Aoki, H; Endo, S; Kanzawa, T; Komata, T; Kondo, S; Nameta, M; Nashimoto, T; Takahashi, H; Tanaka, R; Yamamoto, T | 1 |
| Al-Younes, HM; Brinkmann, V; Meyer, TF | 1 |
| Amici, C; Forini, O; Fossile, E; Gold, B; Graziani, G; Muzi, A; Portarena, I; Tentori, L; Vergati, M | 1 |
| Arakawa-Kobayashi, S; Kanaseki, T; Mizushima, N; Mizuta, T; Shimizu, S; Thompson, CB; Tsujimoto, Y | 1 |
| Connor, EE; Wilson, JJ; Wyatt, MD | 1 |
| Boya, P; Casares, N; Codogno, P; Dessen, P; González-Polo, RA; Kroemer, G; Larochette, N; Meley, D; Métivier, D; Perfettini, JL; Pierron, G; Souquere, S; Yoshimori, T | 1 |
| Dalen, H; Lööf, S; Stroikin, Y; Terman, A | 1 |
| Amadoro, G; Calissano, P; Canu, N; Ciotti, MT; Serafino, AL; Tufi, R | 1 |
| Cho, DH; Choi, B; Jang, MH; Jun, JI; Jung, YK; Kim, JH; Kwon, YK; Lee, H; Lee, HJ; Mizushima, N; Oshumi, Y; Pyo, JO; Woo, HN | 1 |
| Al-Adhami, BH; Doenhoff, MJ; Kusel, R; Noble, C; Sharaf, O; Thornhill, J | 1 |
| Daido, S; Ito, H; Kanzawa, T; Kondo, S; Kondo, Y | 1 |
| Brunk, UT; Dalen, H; Stroikin, Y; Terman, A | 1 |
| Dennis, JW; Guay, G; Lajoie, P; Nabi, IR | 1 |
| Bastholm, L; Elling, F; Høyer-Hansen, M; Jäättelä, M; Mathiasen, IS | 1 |
| Bogdanffy, MS; Frame, SR; Mathison, BH | 1 |
| Botti, J; Carpentier, S; Codogno, P; Ghidoni, R; Lavieu, G; Levade, T; Sala, G; Scarlatti, F | 1 |
| Inoue, Y; Moriyasu, Y | 1 |
| Ahtiainen, L; Jalanko, A; Kauppi, M; Kopra, O; Luiro, K; Tyynelä, J | 1 |
| Gu, ZL; Liang, ZQ; Qin, ZH; Reid, P; Yan, CH; Yang, YP | 1 |
| Ishikawa, Y; Kyuuma, M; Nakashima, A; Saito, S; Sato, H; Sugamura, K; Tamai, K; Tanaka, N; Yoshimori, T | 1 |
| Fujita, E; Isoai, A; Kaufman, RJ; Kominami, E; Kouroku, Y; Kumagai, H; Momoi, T; Ogawa, S; Tanida, I; Ueno, T | 1 |
| Asplund, S; Johansson, U; Ollinger, K; Stroikin, Y | 1 |
| Cui, Q; Ikejima, T; Onodera, S; Tashiro, S | 1 |
| Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W | 1 |
| Campbell-Verduyn, LS; Hunter, KC; Rutledge, LR; Wetmore, SD | 1 |
| Chu, CT; Jennings, JJ; Kiselyov, K; Luo, X; Rbaibi, Y; Zhu, JH | 1 |
| Hattori, M; Inoue, Y; Moriyasu, Y; Ohsumi, Y; Suzuki, T; Yoshimoto, K | 1 |
| Araki, N; Egami, Y; Hamasaki, M; Hatae, T | 1 |
| Eichman, BF; Hollis, T; Metz, AH | 1 |
| Correia, MA; Faouzi, S; Hefner, C; Maher, JJ; Medzihradszky, KF | 1 |
| Ito, S; Koshikawa, N; Mochizuki, S; Takenaga, K | 1 |
| Berka, U; Blaas, D; Brabec-Zaruba, M; Fuchs, R | 1 |
| Ashida, H; Franchi, L; Inohara, N; Mimuro, H; Nuñez, G; Ogawa, M; Sasakawa, C; Suzuki, T; Toma, C; Yoshikawa, Y | 1 |
| Johnson, RE; Prakash, L; Prakash, S; Yu, SL | 1 |
| Kim, JJ; Lee, SB; Park, JS; Tong, SY; Um, SJ | 1 |
| Chen, SG; Cui, Q; Ikejima, T; Li, D; Onodera, S; Tashiro, S; Wu, LJ | 1 |
| Chen, Y; Gibson, SB; Israels, SJ; Kong, J; McMillan-Ward, E | 1 |
| Dunn, SR; Schnitzler, CE; Weis, VM | 1 |
| Archange, C; Gonzalez, CD; Grasso, D; Iovanna, JL; Lo Re, A; Nowak, J; Pardo, R; Ropolo, A; Sacchetti, ML; Seux, M; Vaccaro, MI | 1 |
| Niu, H; Rikihisa, Y; Yamaguchi, M | 1 |
| Fukui, K; Koike, T; Yang, Y; Zheng, X | 1 |
| Buja, LM; Hickson-Bick, DL; Jones, C | 1 |
| Chen, S; Le, W; Li, L; Luo, G; Yang, D; Zhang, X | 1 |
| Cui, Q; Ikejima, T; Minami, M; Onodera, S; Tashiro, S | 1 |
| Gu, ZL; Han, R; Liang, ZQ; Qin, ZH; Wang, Y; Wu, JC; Zhang, XD | 1 |
| Gao, B; Jia, YL; Liang, ZQ; Qin, ZH; Yang, YP | 1 |
| Araki, N; Egami, Y | 1 |
| Andreotti, V; Bisio, A; Ciribilli, Y; Fronza, G; Gold, B; Huang, X; Inga, A; Menichini, P; Monti, P; Perfumo, C; Russo, D | 1 |
| Higaki, K; Kajimaki, K; Matsuda, J; Nanba, E; Ninomiya, H; Ohno, K; Otsuka, S; Suzuki, Y; Takamura, A | 1 |
| Dermentzaki, G; Lang-Rollin, I; Rideout, HJ; Stefanis, L; Vekrellis, K; Xilouri, M | 1 |
| Burch, L; Craig, A; Gordon-Weeks, P; Harrison, B; Hupp, TR; Kraus, M; Stevens, C | 1 |
| Zeng, M; Zhou, JN | 1 |
| Gottlieb, RA; Huang, C; Iwai-Kanai, E; Kim, L; Perry-Garza, CN; Sayen, MR; Yuan, H | 1 |
| Kaushal, GP; Kaushal, V; Shah, SV; Yang, C | 1 |
| García-Escudero, V; Gargini, R; Izquierdo, M | 1 |
| Boya, P; de la Rosa, EJ; Mellén, MA | 1 |
| Chadt, J; Nilsson, R; Sykora, D; Vodicka, P | 1 |
| Dong, Z; Jiang, M; Periyasamy-Thandavan, S; Smith, R; Wei, Q; Yin, XM | 1 |
| Barron, E; Hinton, DR; Lee, AS; Lee, B; Li, J; Ni, M | 1 |
| Fukunaga, K; Han, F; Han, R; Qin, ZH; Sheng, R; Wen, YD; Zhang, LS; Zhang, X; Zhang, XD | 1 |
| Gao, G; Luo, H; Mao, I; McManus, BM; Si, X; Wong, J; Zhang, J | 1 |
| Dent, P; Fisher, PB; Graf, M; Grant, S; Gupta, S; Hamed, H; Hylemon, PB; Mitchell, C; Park, MA; Rahmani, M; Studer, E; Walker, T; Zhang, G | 1 |
| Choe, H; Choi, JE; Hwang, O; Kim, DH; Kim, SW; Kweon, HS; Lee, H; Lee, JY; Yoon, SY | 1 |
| Li, X; Lu, L; Wu, W; Yan, J; Yu, H; Yu, X | 1 |
| Cho, CH; Li, ZJ; Sung, JJ; Wu, WK; Wu, YC; Yu, L | 1 |
| Bae, D; Lu, S; Mercurio, AM; Taglienti, CA | 1 |
| Fujiwara, H; Fujiwara, T; Goto, K; Horie, T; Kanamori, H; Maruyama, R; Minatoguchi, S; Miyata, S; Nagao, K; Nagashima, K; Ono, K; Takemura, G; Tsujimoto, A; Ushikoshi, H | 1 |
| Ge, JN; Gong, JP; Huang, D; Li, XL; Tao, DD; Wang, Z; Xiao, H; Xiao, T | 1 |
| Valentin, M; Yang, E | 1 |
| Balduini, W; Buonocore, G; Carloni, S | 1 |
| Ahn, J; Choi, JE; Ha, YE; Kim, DH; Kweon, HS; Lee, H; Lee, JY; Yoon, SY | 1 |
| Chang, IY; Hou, YF; Kim, YS; Lim, SC; Oh, SH; You, HJ | 1 |
| Akira, S; Fujita, N; Jang, MH; Kawai, T; Komatsu, M; Noda, T; Omori, H; Saitoh, T; Satoh, T; Takeuchi, O; Tanaka, K; Tsujimura, T; Uematsu, S; Yamamoto, N; Yang, BG; Yoshimori, T | 1 |
| Anwar, T; Beraldi, R; Caselli, G; Di Vito, M; Indelicato, M; Letari, O; Makovec, F; Morgante, E; Pucci, B; Russo, MA; Sale, P; Schito, L; Spadafora, C; Tafani, M | 1 |
| Gonzalez-Alegre, P; Gordon, KL | 1 |
| Barbier, S; Bras, M; Merle-Béral, H; Roué, G; Sarfati, M; Susin, SA | 1 |
| Chen, CS; Chen, KF; Cheng, AL; Feng, WC; Gao, M; Hsu, CH; Kuo, ML; Lee, WC; Lu, YS; Yeh, PY | 1 |
| La Spada, AR; Martinez, RA; Young, JE | 1 |
| Ambrosio, S; Francisco, R; Giménez-Xavier, P; Pérez, R; Platini, F | 1 |
| Endo, S; Hayakawa, Y; Hayashi, N; Kamiyama, H; Kitajima, I; Kurimoto, M; Nagai, S; Tsuboi, Y | 1 |
| Akiyama, Y; Bögler, O; Fujiwara, K; Kondo, S; Moritake, K; Shingu, T; Shinojima, N; Tamada, Y; Yokoyama, T | 1 |
| Lei, HY; Wang, YH; Wu, JJ | 1 |
| Fan, Z; Gao, GF; Hu, X; Jiang, X; Liu, D; Wang, M; Yan, J; Zhou, Z | 1 |
| Hailey, DW; Kim, PK; Lippincott-Schwartz, J; Mullen, RT | 1 |
| Alibek, K; Kusuma, CM; St John, LJ; Tan, YK; Vu, HA; Wu, A | 1 |
| Bahn, JJ; Chu, K; Jung, KH; Kim, M; Lee, SK; Lee, ST; Park, HK; Roh, JK | 1 |
| Faried, A; Hou, N; Kuwano, H; Li, J; Takeuchi, T; Tsutsumi, S | 1 |
| Ahn, J; Choi, JE; Ha, YE; Kim, DH; Lee, H; Yoon, SY | 1 |
| Ichimura, K; Kanekatsu, M; van Doorn, WG; Yamada, T | 1 |
| Chen, Y; Jin, C; Li, S; Li, Y; Lin, J; Liu, S; Ren, X; Sheng, F; Tian, S; Wang, L; Wang, N; Xia, B; Xiao, J; Yu, W; Zhao, F; Zheng, Z; Zhong, W | 1 |
| Cho, CH; Li, HT; Li, ZJ; Sung, JJ; Wu, WK; Wu, YC; Yu, L | 1 |
| Fukunaga, K; Gu, ZL; Han, F; Han, R; Liang, ZQ; Qin, ZH; Wang, Y; Wu, JC; Zhang, X; Zhang, XD | 1 |
| Kharbanda, S; Kufe, D; Yin, L | 1 |
| Kang, J; Kong, X; Li, Y; Su, J; Sun, L; Zhang, H; Zhong, J | 1 |
| Benavides, A; Frost, P; Hoang, B; Lichtenstein, A; Shi, Y | 1 |
| Clarke, PG; Mottier, V; Puyal, J; Vaslin, A | 1 |
| Fukunaga, K; Han, F; Han, R; Lin, F; Qin, ZH; Wang, Y; Wu, JC; Zhang, XD | 1 |
| Gao, FB; Lee, JA | 1 |
| Bu, XX; Guo, XL; Hu, F; Li, R; Ma, NN; Song, JR; Sun, K; Tao, SF; Wei, LX; Wu, MC; Xiong, HY; Zhang, SS | 1 |
| Fronza, G; Gold, B; Inga, A; Iyer, P; Menichini, P; Monti, P; Ottaggio, L; Russo, D | 1 |
| Rami, A; Steiger-Barraissoul, S | 1 |
| Currin, RT; Kai, Y; Lemasters, JJ; Maldonado, E; Rodriguez-Enriquez, S | 1 |
| Gao, L; Guo, X; Qu, Z; Shen, F; Song, J; Sun, K; Wei, L; Wu, M; Zhao, Q; Zhao, X | 1 |
| Bamba, H; Hisa, Y; Sato, T; Tooyama, I; Urushitani, M | 1 |
| Chai, Y; Hu, H; Kim, SH; Lee, HJ; Lü, J; Wang, L; Zhang, J | 1 |
| Hongo, K; Kitayama, J; Nagawa, H; Nishikawa, T; Okaji, Y; Sasaki, K; Shuno, Y; Sunami, E; Takahashi, K; Tsuno, NH | 1 |
| Brenman, JE; Forsberg, LJ; Viollet, B; Williams, T | 1 |
| Casolari, L; Fronza, G; Gold, B; Inga, A; Iyer, P; Menichini, P; Monti, P; Ottaggio, L; Russo, D; Traverso, I | 1 |
| Kobayashi, S; Liang, Q; Mao, K; Timm, D; Volden, P; Xu, X | 1 |
| Izutani, Y; Nakamura, Y; Otsuji, E; Sakai, T; Watanabe, H; Yogosawa, S | 1 |
| Tan, KSW; Ye, AJJ; Yin, J | 1 |
| Belloni, D; Caligaris-Cappio, F; Dell'Antonio, G; Ferrarini, M; Ferrero, E; Foglieni, C; Veschini, L | 1 |
| Ande, SR; Chazin, WJ; Eshragi, M; Ghavami, S; Halayko, AJ; Hashemi, M; Kerkhoff, C; Klonisch, T; Los, M; McNeill, KD | 1 |
| Fan, H; Li, B; Wang, G; Wang, H; Wang, X; Ying, Z | 1 |
| Abramson, MA; Donner, DB; Jiang, X; Lin, CI; Moore, FD; Price, BD; Ruan, DT; Whang, EE | 1 |
| Dong, J; Huang, Q; Lou, M; Qin, Z; Wang, A; Yang, J; Zhang, T; Zhao, Y | 1 |
| Chang, RC; Cheung, YT; Hung, CH; Lai, CS; So, KF; Yu, MS; Zhang, NQ | 1 |
| Liu, D; Liu, Q; Wang, J; Yang, Y | 1 |
| Batist, G; Brisson, ML; Haidara, K; Kandouz, M; Zhao, J | 1 |
| Holz, FG; Kopitz, J; Krohne, TU; Stratmann, NK | 1 |
| Hwang, J; Kim, DR; Kim, H; Kwon, TK; Lee, JT; Lee, S; Park, HC; Suk, K | 1 |
| Dong, Z; Jiang, M; Liu, K; Luo, J | 1 |
| Cao, Y; Dong, XX; Gu, ZL; Han, R; Liang, ZQ; Qin, ZH; Wang, Y; Wu, JC | 1 |
| Chai, L; Cheng, M; Ren, Y; Wang, S; Xie, Y | 1 |
| Aventaggiato, M; Fini, M; Indelicato, M; Mazzarino, MC; Pucci, B; Reali, V; Russo, MA; Schito, L; Stivala, F; Tafani, M | 1 |
| Bauvy, C; Codogno, P; Huang, Q; Ong, CN; Shen, HM; Shui, G; Tan, HL; Wenk, MR; Wu, YT | 1 |
| Churchill, CD; Rutledge, LR; Wetmore, SD | 1 |
| Chrysanthopoulou, A; Kambas, K; Kourtzelis, I; Mitroulis, I; Rafail, S; Ritis, K; Speletas, M | 1 |
| Hayes, RL; Kobeissy, FH; Larner, SF; Liu, MC; Sadasivan, S; Wang, KK; Zhang, Z; Zheng, W | 1 |
| Beljanski, V; Knaak, C; Smith, CD | 1 |
| Faried, A; Hou, N; Kuwano, H; Li, J; Tsutsumi, S | 1 |
| Alvarez, EM; Archange, C; Gonzalez, CD; Iovanna, JL; Lo Ré, A; Papademetrio, DL; Pardo, R; Ropolo, A; Vaccaro, MI | 1 |
| Castino, R; Falnoga, I; Isidoro, C; Lah, TT; Mirković, B; Pucer, A; Slejkovec, Z | 1 |
| Houseman, BT; Miller, S; Oleksy, A; Perisic, O; Shokat, KM; Tavshanjian, B; Williams, RL | 1 |
| Box, AH; Demetrick, DJ; Kim, SM | 1 |
| Bandyopadhyay, U; Cuervo, AM; Figliola, M; Gauthier, S; Grubb, A; Kumar, AR; Levy, E; Mohan, P; Nixon, RA; Pawlik, M; Sahoo, S; Tizon, B; Uchiyama, Y; Yu, H | 1 |
| Kotake, Y; Nakatsu, Y; Ohta, S; Takai, N | 1 |
| Gao, B; Han, R; Liu, XQ; Qin, ZH; Sheng, R; Zhang, LS | 1 |
| Amarnath, S; Costanzo, CM; Eckhaus, M; Flomerfelt, FA; Foley, JE; Fowler, DH; Gangopadhyay, A; June, CH; Konecki, DM; Levine, BL; Mariotti, J; Wong, S | 1 |
| Choi, CH; Jung, YK; Oh, SH | 1 |
| Babetto, E; Beirowski, B; Coleman, MP; Garcia-Alias, G; Nógrádi, A | 1 |
| Duan, W; Ikejima, T; Jin, X; Li, Q; Onodera, S; Tashiro, S | 1 |
| Bähr, M; Knöferle, J; Koch, JC; Lingor, P; Ostendorf, T; Tönges, L | 1 |
| Fronza, G; Gold, B; Inga, A; Iyer, P; Menichini, P; Monti, P; Ottaggio, L; Perfumo, C; Russo, D | 1 |
| Biswas, SK; Bonewald, LF; Gluhak-Heinrich, J; Jiang, JX; Kar, R; Lane, NE; Lo, WK; Xia, X; Yao, W | 1 |
| Miller, S; Oleksy, A; Perisic, O; Williams, RL | 1 |
| Hong, LZ; Liu, CF; Liu, J; Qin, AP; Qin, YY; Qin, ZH; Xu, M; Yang, L; Zhang, HL | 1 |
| Deng, R; Feng, GK; Gao, YH; Jiang, S; Li, DD; Li, HJ; Wei, ZX; Wu, KW; Wu, XQ; Yang, F; Zhu, XF | 1 |
| Chang, SP; Chang, YP; Chen, CL; Chen, SH; Cheng, YL; Choi, PC; Hsieh, CY; Huang, WC; Kai, JI; Lin, CF; Lin, YS; Liu, HS; Tsai, CC; Wang, CY | 1 |
| Chen, RJ; Ho, CT; Wang, YJ | 1 |
| Karnataki, A; Orlofsky, A; Parsons, M; Wang, Y; Weiss, LM | 1 |
| Agostinis, P; de Witte, PA; Dewaele, M; Martinet, W; Piette, J; Rubio, N; Verfaillie, T | 1 |
| Aránguiz-Urroz, P; Canales, J; Carrillo, C; Copaja, M; Díaz-Araya, G; Lara, H; Lavandero, S; Troncoso, R; Vicencio, JM | 1 |
| An, QX; Chen, R; Hu, XB; Huang, XF; Mu, SJ; Wu, DC; Xia, AJ; Yang, SM; Yi, J; Zhan, YH; Zhang, XQ | 1 |
| López-Pérez, AI; López-Rivas, A; Martín-Pérez, R; Palacios, C; Pandiella, A | 1 |
| Fukamoto, K; Funayama, T; Hamada, N; Hino, M; Kobayashi, Y; Morimura, Y; Mutou, Y; Sakashita, T; Tajika, Y; Yokota, Y; Yorifuji, H | 1 |
| Bravo-San Pedro, JM; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; Niso-Santano, M | 1 |
| Ku, Y; Mukubou, H; Sasaki, R; Tsujimura, T | 1 |
| Feng, X; Gong, Y; Ni, H; Tao, LY; Wu, XR | 1 |
| Bowman, BR; Lee, S; Verdine, GL; Wang, S | 1 |
| Li, Y; Liu, Q; Wang, P; Wang, X; Wang, Z; Yang, L; Zhao, P; Zhao, X | 1 |
| Chen, CC; Liu, YL; Shun, CT; Weng, JR; Wu, MS; Yang, PM | 1 |
| Choi, KS; Kwon, TK; Park, EJ | 1 |
| Eum, KH; Lee, M | 1 |
| Gean, PW; Hsiao, M; Lin, CH; Liu, WT | 1 |
| Kim, I; Lemasters, JJ | 1 |
| Choi, HJ; Choi, JK; Kim, AY; Kim, W; Koh, EK; Koh, YH; Park, N; Park, Y; Seo, J | 1 |
| Chatterjea, SM; Fleckman, P; Nirunsuksiri, W; Old, W; Resing, KA | 1 |
| Aymard, E; Barruche, V; Bordes, S; Closs, B; Naves, T; Ratinaud, MH; Verdier, M | 1 |
| Chen, T; Chen, YS; Fu, T; Kan, B; Li, X; Liu, H; Lu, Y; Song, HX; Xue, JX; Yang, G; Zhang, Y | 1 |
| Das, ZC; Gupta, MK; Lee, HR; Lee, HT; Park, MR; Uhm, SJ | 1 |
| Cheng, KT; Huang, SH; Huang, ST; Kao, YT; Lee, CM; Lin, CM; Wu, JY; Yu, SH | 1 |
| Huang, H; Ikejima, T; Jiang, YY; Onodera, S; Tashiro, S; Wang, HJ; Wu, D; Yang, R | 1 |
| Ai, ZL; Gao, C; Jin, B; Lv, DC; Ma, DL; Shu, XM; Wu, CL; Xie, BS; Yao, SK; Zhao, HC; Zhuo, DX | 1 |
| Chen, L; Chen, X; Dong, B; Dong, H; Gao, G; Gao, Y; Pan, Y; Yang, Y | 1 |
| Agostinis, P; Claerhout, S; De Vos, R; Garmyn, M; Proby, C; Van Kelst, S; Verschooten, L | 1 |
| Dey, SK; Jun, JH; Lee, JE; Lim, HJ; Oh, HA; Roh, CR; Song, H; Xie, H | 1 |
| Crisan, TO; de Jong, DJ; Girardin, SE; Joosten, LA; Netea, MG; Oosting, M; Philpott, DJ; Plantinga, TS; van de Veerdonk, FL; van der Meer, JW | 1 |
| Chu, KT; Luo, BY; Pan, J; Sun, LN; Wang, JY; Wang, K; Wang, Q; Xia, Q; Zeng, B; Zhu, YJ | 1 |
| Besirli, CG; Chinskey, ND; Zacks, DN; Zheng, QD | 1 |
| Knight, RA; Latchman, DS; McCormick, J; Scarabelli, TM; Stephanou, A; Suleman, N | 1 |
| Chiang, HC; Chou, FP; Kuo, WH; Liu, WS; Tseng, HC; Tyan, YS | 1 |
| Chiu, LY; Hsin, IL; Jan, MS; Ko, JL; Lue, KH; Ou, CC; Wu, MF; Wu, TC | 1 |
| Crişan, TO; Farcaş, MF; Joosten, LA; Kullberg, BJ; Netea, MG; Plantinga, TS; Stoffels, M; van de Veerdonk, FL; van der Meer, JW | 1 |
| Armant, DR | 1 |
| Amor, EC; Kim, HC; Kim, HJ; Kim, YJ; Ko, H; Lee, JW; Yang, HO | 1 |
| Herbst, S; Schaible, UE; Schneider, BE | 1 |
| Ikejima, T; Li, L; Liu, B; Onodera, S; Tashiro, S; Yang, P; Ye, Y; Zhou, Y | 1 |
| Chen, L; Garcia-Garcia, A; Gomez-Gutierrez, JG; McMasters, KM; Rao, XM; Rodriguez-Rocha, H; Zhou, HS | 1 |
| Guo, F; Jiang, CY; Li, CG; Liu, HL; Liu, XQ; Sun, Y; Wang, YG; Yang, N; Yang, P; Zhang, GG; Zhang, YL; Zhang, YX; Zhao, Y | 1 |
| Ikeda, S; Kanamitsu, K | 1 |
| Chen, SD; Ding, JQ; Ma, JF; Pan, J; Wang, XQ; Xin, XY; Yang, GY | 1 |
| Chen, GQ; Chen, TT; Hou, JK; Huang, Y; Kogan, SC; Yan, ZW; Yang, J; Zhang, J; Zhao, XY | 1 |
| Hwang, KC; Kim, NH; Lee, SE; Sun, SC; Xu, YN | 1 |
| Aracil, M; Cuervo, AM; Jimeno, J; Ling, YH; Lu, B; Perez-Soler, R; Yuan, Z; Zou, Y | 1 |
| Fukumoto, M; Kuwahara, Y; Mori, S; Ochiai, Y; Ohkubo, Y; Ohtake, Y; Oikawa, T; Roudkenar, MH; Shimura, T; Uchiyama, Y | 1 |
| Chaachouay, H; Kehlbach, R; Multhoff, G; Ohneseit, P; Rodemann, HP; Toulany, M | 1 |
| Cagnin, M; Castino, R; Fiorentino, I; Giovia, A; Isidoro, C | 1 |
| Bosone, A; Conte, D; Gianetto, D; Piras, A; Vercelli, A | 1 |
| Abe, A; Miyazawa, K; Moriya, S; Yamada, H | 1 |
| Cao, L; Kang, R; Liu, L; Tang, D; Wang, Z; Xie, M; Yang, L; Yang, M; Yu, Y; Zhang, H; Zhao, M | 1 |
| Chen, S; Fan, S; Ikejima, T; Li, L; Onodera, S; Qi, M; Tashiro, S; Yu, Y | 1 |
| Rutledge, LR; Wetmore, SD | 1 |
| Briant, L; Denizot, M; Gasque, P; Gay, B; Hoarau, JJ; Jaffar-Bandjee, MC; Krejbich-Trotot, P; Li-Pat-Yuen, G | 1 |
| Allamand, V; Carmignac, V; Durbeej, M; Elowsson, L; Gawlik, KI; Körner, Z; Matsumura, C; Svensson, M | 1 |
| Chen, CH; Chen, HF; Chen, PH; Chiang, SC; Chien, CL; Chien, YH; Chuang, CY; Ho, HN; Huang, HP; Hwu, WL; Kuo, HC; Li, LT; Stone, L | 1 |
| Badmaev, V; Ho, CT; Lai, CS; Nagabhushanam, K; Pan, MH; Wu, JC | 1 |
| Sun, S; Tong, H; Tu, Y; Wang, G; Wei, W; Yao, F | 1 |
| Bockus, A; Boggess, N; Ding, WX; Jaeschke, H; Ni, HM | 1 |
| Ji, WJ; Liang, ZQ; Long, LM; Zhuang, WZ | 1 |
| Anoopkumar-Dukie, S; Davey, AK; Grant, GD; McFarland, AJ; Perkins, AV | 1 |
| Deguchi, T; Doki, Y; Eguchi, H; Ito, T; Kobayashi, S; Machida, T; Marubashi, S; Mori, M; Nagano, H; Ohmura, Y; Tanemura, M; Tsukamoto, R; Wada, H | 1 |
| Xi, XY; Zhang, XY; Zhao, ZD | 1 |
| Dolan, PJ; Hwang, W; Jin, YN; Johnson, GV | 1 |
| Cao, S; Cao, T; Fan, J; Huang, F; Li, S; Mao, H; Wang, Y; Yu, X; Zhou, Y; Zhuang, S | 1 |
| Kang, J; Li, H; Qin, H; Su, J; Sun, L; Xu, Y; Yu, C; Yu, H; Zhong, J | 1 |
| Du, J; Eis, A; Guan, T; Kaul, S; Konduri, GG; Shi, Y; Teng, RJ | 1 |
| Ceña, V; Luján, R; Martínez-Hernández, J; Merino, S; Pérez-Carrión, MD; Pérez-Martínez, FC; Sánchez-Verdú, P | 1 |
| Higuchi, T; Hillmer, S; Inoue, Y; Moriyasu, Y; Robinson, DG; Takatsuka, C | 1 |
| Allegood, JC; Edmonds, Y; Lépine, S; Milstien, S; Spiegel, S | 1 |
| Choi, EJ; Kim, HL; Kim, J; Kim, WY; Kim, YK; Kim, YS; Ko, JS; Nam, SA; Park, SH; Song, HC | 1 |
| Choi, D; Choi, J; Jo, M; Lee, E; Oh, YK | 1 |
| Benedikz, E; Cedazo-Minguez, A; Cowburn, RF; Dehvari, N; Hallbeck, M; Kågedal, K; Marcusson, J; Terman, A; Zheng, L | 1 |
| Dang, C; Fan, Y; Li, C; Li, J; Li, Y; Pei, Z; Xing, S; Yu, J; Zeng, J; Zhang, J; Zhang, Y | 1 |
| Du, H; Guan, YF; Miao, CY; Su, DF; Wang, P; Zhai, QW | 1 |
| Braasch, K; Butler, M; Côté, HC; Gorski, SM; Jardon, MA; Leung, AO; Piret, JM; Sattha, B | 1 |
| Kashiwagi, A; Kondo, M; Kume, S; Kusunoki, C; Maegawa, H; Morino, K; Nishio, Y; Sekine, O; Ugi, S; Uzu, T; Yasuda, M; Yoshizaki, T | 1 |
| Ireland, JM; Unanue, ER | 1 |
| Balduini, W; Buonocore, G; Carloni, S; Longini, M; Proietti, F | 1 |
| Ghosh, D; Roepe, PD; Sinai, AP; Walton, JL | 1 |
| Hao, S; Hou, J; Jia, Z; Liu, C; Ruan, X; Wang, L; Yu, Z; Zhang, X; Zheng, Y | 1 |
| Barbosa, CM; Bechara, A; Bincoletto, C; Calgarotto, AK; da Silva Pereira, GJ; de Souza Queiroz, ML; Hirata, H; Paredes-Gamero, EJ; Smaili, SS | 1 |
| Czaja, MJ; Fiel, MI; Friedman, SL; Ghiassi-Nejad, Z; Gordon, R; Hernández-Gea, V; Rozenfeld, R; Yue, Z | 1 |
| Arroba, AI; Boya, P; Cecconi, F; de la Rosa, EJ; de Pablo, F; Vázquez, P | 1 |
| Du, J; Eis, A; Guan, T; Konduri, GG; Shi, Y; Teng, RJ; Welak, S | 1 |
| Chanvorachote, P; Pengsuparp, T; Sirichanchuen, B | 1 |
| Beguinot, F; Botta, G; Cabaro, S; Formisano, P; Iovane, V; Iovino, S; Oriente, F; Paciello, O; Perruolo, G; Viggiano, D | 1 |
| Lawley, PD; Warren, W | 1 |
| Chang, PA; Chen, YY; Long, DX; Mou, XL; Qin, WZ | 1 |
| Chen, Z; Hu, WW; Shen, Z; Wang, GH; Wang, Z; Yang, Y; Zhang, XN | 1 |
| Huang, J; Lin, J; Ruan, S; Xu, Y; Yang, S; Zheng, Z | 1 |
| Antoszczyk, SJ; Kanai, R; Martuza, RL; Rabkin, SD; Sgubin, D; Wakimoto, H; Zaupa, C | 1 |
| Gao, B; Han, R; Liu, XQ; Qin, ZH; Sheng, R; Wu, YQ; Zhang, LS; Zhang, XY | 1 |
| Chen, C; Du, G; Guo, F; Hu, S; Qiao, J; Ren, Y; Wang, Y; Zhang, H; Zhang, K | 1 |
| Devadas, K; Gao, Y; Hewlett, I; Ragupathy, V; Takeda, K; Tan, J; Wang, X; Zhao, J | 1 |
| Deng, WJ; Guo, XL; Hu, F; Li, D; Song, JR; Song, YJ; Sun, K; Wei, LX; Wu, MC; Xie, XQ; Zhang, SS; Zhao, QD | 1 |
| Biagioni, F; Fabrizi, C; Fornai, F; Fumagalli, L; Lenzi, P; Pompili, E; Somma, F | 1 |
| Goldstein, LS; Kidwell, CU; Ordonez, MP; Plaisted, WC; Roberts, EA; Yuan, SH | 1 |
| Guo, R; Hu, N; Kandadi, MR; Ren, J | 1 |
| Abagnale, A; Barbato, S; Beguinot, F; Botta, G; Formisano, P; Hallden, G; Libertini, S; Maione, AS; Passaro, C; Portella, G | 1 |
| Kim, JH; Park, CK; Park, HY | 1 |
| Manthey, KC; Morris, CR; Oh, KB; Stanton, MJ; Wagner, KU | 1 |
| Chen, K; Kobayashi, S; Liang, Q; Xu, X | 1 |
| Ding, ZB; Fan, J; Gu, CY; Hui, B; Liu, WR; Peng, YF; Shi, GM; Shi, YH; Yang, H; Zhou, J | 1 |
| Chen, G; Jing, CH; Liu, PP; Ruan, D; Wang, L; Wu, C | 1 |
| Chen, D; Hao, Q; Hou, H; Huang, Y; Lv, L; Shi, Q; Yi, Q; Zhang, T; Zhang, Y | 1 |
| Cheng, E; Ganaie, SS; Haque, A; Hussein, IT; Mir, MA; Sheema, S; Werle, MJ | 1 |
| Chen, M; Lee, JK; Michelson, AZ; Wang, K | 1 |
| Ehrlich, M; Pinkas-Kramarski, R; Schmukler, E; Shai, B | 1 |
| Menshikov, M; Pliyev, BK | 1 |
| Carter, LG; Coote, PJ; Graham, S; Liu, H; Naismith, J; Yan, X; Zhu, X | 1 |
| Chen, YW; Chow, SE; Huang, YK; Liang, CA; Wang, JS | 1 |
| Chen, Y; Ding, ZT; Jiang, YP; Lan, DM; Liu, FT; Ren, HM; Wang, J; Wu, JJ; Yue, ZY; Zhao, J | 1 |
| Carlson, AL; Durum, SK; Khaled, AR; Li, W; Limaye, A; Ruppert, SM; Zhang, G | 1 |
| Bao, HJ; Chang, P; Chen, XP; Dai, DK; Dong, WW; Liu, WL; Tao, LY; Wang, L; Wang, T; Wang, YQ; Zhang, L; Zhang, MY | 1 |
| Hao, HP; Hu, XC; Huang, L; Ishag, HA; Li, C; Li, PP; Mao, X; Sun, MX; Wang, R; Yu, YL | 1 |
| Feuer, R; Gottlieb, RA; Sayen, MR; Tabor-Godwin, JM; Tsueng, G | 1 |
| Ahn, MY; Choi, WS; Jung, JH; Kim, HS; Kim, TH; Lee, BM; Lee, J; Wang, J; Yoon, KS; Yoon, S | 1 |
| Dixit, D; Ghildiyal, R; Sen, E | 1 |
| Chowdhury, RD; Driscoll, JJ | 1 |
| Cui, XS; Heo, YT; Kim, DJ; Kim, NH; Kwon, JS; Lee, SE; Shen, XH; Xu, YN | 1 |
| Heckmann, BL; Liu, J; Yang, X; Zhang, X | 1 |
| Chen, H; Huang, C; Jiao, B; Miao, M; Shang, Z; Sun, W; Wang, B; Yuan, B; Zhao, Y | 1 |
| Liu, CX; Ma, CM; Sun, Y; Wei, W; Wu, YL; Yan, H; Zhao, S | 1 |
| Chen, Q; Lin, JM; Liu, W; Wu, J; Zhang, Y | 1 |
| Arrizabalaga, G; Lavine, MD | 1 |
| Banerjee, S; Chakrabarti, A; Gaughan, C; Ghosh, PK; Silverman, RH | 1 |
| Carp, RI; Choi, EK; Kim, YS; Oh, JM | 1 |
| Chandra, D; Gogada, R; Jones, A; Lella, R; Lovett, G; Marlowe, T; Minderman, H; O'Loughlin, K; Schneider, A; Srivastava, P; Yadav, N | 1 |
| D'Alessio, A; Facchiano, A; Filippini, A; Giampietri, C; Marini, ES; Padula, F; Petrungaro, S; Ziparo, E | 1 |
| Bao, XX; Li, Q; Li, XP; Wang, JL; Wei, LH; Xie, BS | 1 |
| Hou, KZ; Liu, J; Liu, YP; Qu, XJ; Wang, KF; Wu, B; Zhan, YH | 1 |
| Araújo, AP; Cyrino, LT; Giorgio, S; Joazeiro, PP; Vicente, CP | 1 |
| Hammerová, J; Slaninová, I; Táborská, E; Uldrijan, S; Vaculová, AH | 1 |
| Cao, J; Du, NC; Ji, LN; Liu, JJ; Wei, L; Yang, XL | 1 |
| Kuo, HC; Lin, WW; Lin, YC; Wang, JS | 1 |
| Harris, J; Hearnden, CA; Jones, SA; Lavelle, EC; Mills, KH; Ní Cheallaigh, C; Peral de Castro, C; Williams, L; Winter, J | 1 |
| Castonguay, A; Doucet, C; Juhas, M; Maysinger, D | 1 |
| Cui, G; Gao, L; Gu, L; Guo, J; Jiang, T; Liu, Y; Su, L; Zhang, Y | 1 |
| Chao, MR; Hu, CW | 1 |
| Aburto, MR; Hurlé, JM; Magariños, M; Sánchez-Calderón, H; Varela-Nieto, I | 1 |
| Cui, L; Dai, F; Jing, H; Li, H; Zhang, L; Zhou, B; Zhou, G | 1 |
| Jin, X; Kong, X; Li, H; Xing, Y; Zhang, Z | 1 |
| Abaturova, SB; Beljelarskaya, SN; Erokhov, PA; Lyupina, YV; Mikhailov, VS; Orlova, OV | 1 |
| Fan, X; Liang, HP; Tu, YJ; Yang, X; Zhang, C | 1 |
| Dai, J; Jiang, Y; Liu, X; Wu, L; Xu, G; Zhu, J | 1 |
| Anderson, C; Buss, LW; Kritzberger, C; Lakkis, FG; Moreno, MA; Poudyal, M; Westerman, E | 1 |
| Lei, FR; Li, XQ; Liu, H; Meng, QY; Rong, JJ; Zhu, RD | 1 |
| Cai, A; Li, L; Li, Y; Xu, L; Zhong, X | 1 |
| Fan, K; Guo, H; Tang, J; Wang, JJ; Wang, JS; Zhang, J; Zheng, ZK | 1 |
| Bobola, MS; Fouquerel, E; Gold, B; Iyer, P; Mascara, GP; Sidone, B; Silber, JR; Singh, SK; Sobol, RW; Srinivasan, A; Svilar, D; Zayitova, S | 1 |
| Costanzo, C; Dalla Pozza, E; Dando, I; Donadelli, M; Fiorini, C; Gregorelli, A; Menegazzi, M; Padroni, C; Palmieri, M | 1 |
| Chen, J; Li, Q; Liu, DC; Ren, F; Shu, G; Xie, B; Yuan, L; Zhou, J | 1 |
| Cicchini, L; Griffin, LM; Pyeon, D | 1 |
| Moad, AI; Muhammad, TS; Oon, CE; Tan, ML | 1 |
| Akin, D; Bélanger, M; Chadda, AS; Dunn, W; Progulske-Fox, A; Reyes, L; Rodrigues, PH; Wallet, SM | 1 |
| Guan, Z; Ou, YK; Peng, JR; Tang, ZP; Xu, YD | 1 |
| Aebersold, DM; Bladt, F; Blaukat, A; Fey, MF; Humbert, M; Medová, M; Tschan, MP; Zimmer, Y | 1 |
| Amaral, C; Azevedo, M; Chen, S; Correia-da-Silva, G; da Silva, ET; Roleira, FM; Teixeira, N; Varela, C | 1 |
| Chen, SD; Ding, JQ; Jiang, TF; Liu, J; Tian, LP; Wang, HM; Zhang, YJ; Zhou, HY | 1 |
| Koh, HC; Lee, JE; Park, JH; Shin, IC | 1 |
| La Cour, KH; Ren, J; Richmond, KL; Wang, XM; Zhang, B; Zhang, Y | 1 |
| Amagaya, S; Hsu, YM; Huang, WW; Kuo, SC; Lee, MR; Lin, C; Lin, MW; Peng, SF; Tsai, SC; Tseng, MT; Wu, TS; Yang, JS | 1 |
| Chen, L; Fu, JX; Gao, LS; Zhang, H; Zhang, XH; Zhang, YY | 1 |
| Cai, Y; Dai, XY; Guan, QC; Guan, Y; Kong, W; Wang, X; Xu, MJ; Zhao, MM; Zhao, Y; Zhu, WG | 1 |
| Han, L; Li, H; Wei, C; Yang, X; Zhang, L | 1 |
| Antileo, E; Chiong, M; Fernández, J; Garri, C; Lavandero, S; Muñoz, JP; Nualart, F; Núñez, MT; Tapia, V | 1 |
| Cheng, WT; Fang, K; Guo, ZX; Hsieh, CH; Li, DY; Li, HF; Song, DC | 1 |
| Chen, X; Ding, G; Ma, T; Singhal, PC; Zha, D; Zhu, J | 1 |
| Anand, PK; Buffen, K; Joosten, LAB; Kanneganti, TD; Mennens, S; Netea, MG; Oosting, M; Plantinga, TS; Sturm, P; van de Veerdonk, FL; van der Meer, JWM; Xavier, RJ | 1 |
| Dong, DL; Guo, WT; Liu, X; Sheng, Y; Sun, B; Xing, Y; Zhang, YH | 1 |
| Chen, X; He, W; Jiao, Z; Li, Y; Liu, T; Liu, X; Ma, H; Wang, F; Zeng, X; Zhang, J | 1 |
| Guo, H; Shi, ZJ; Wang, X; Wu, Y; Yu, L; Zhang, B; Zhang, XB | 1 |
| Fang, R; Fang, Y; He, Y; Huang, L; Xue, Z; Zhang, S | 1 |
| Bhatnagar, A; Cummins, TD; Hill, BG; Jones, SP; Salabei, JK; Singh, M | 1 |
| Buchan, AM; Chen, R; Drakesmith, CW; Hadley, G; Hoyte, LC; Kessler, B; McMenamin, MM; Nagel, S; Papadakis, M; Tsaknakis, G; Vekrellis, K; Watt, SM; Wood, MJ; Xilouri, M; Zhao, Z | 1 |
| Del Bello, B; Maellaro, E; Moretti, D; Toscano, M | 1 |
| Cahill, MR; Crowley, LC; Elzinga, BM; McKenna, SL; Nyhan, MJ; O'Donovan, TR | 1 |
| Agarwal, C; Agarwal, R; Raina, K; Serkova, NJ; Wadhwa, R | 1 |
| Chou, B; Hiromatsu, K; Imafuku, S; Ishii, K; Itoh, R; Nakayama, J; Sato, E; Soejima, T | 1 |
| Hou, J; Huang, H; Liu, X; Tang, H; Wang, C; Wang, M; Wang, Y; Weng, J; Zhang, R | 1 |
| Aki, T; Komatsu, M; Kuwahira, I; Maeda, H; Nagai, H; Ogura, S; Shintani-Ishida, K; Shirai, M; Takemura, G; Yoshida, K | 1 |
| Abe, H; Fujii, S; Hashiguchi, A; Miyazawa, Y; Sakai, R; Sakamoto, M; Uekita, T | 1 |
| Anderson, CD; Dorsett-Martin, WA; Drake, LC; Morris, MW; Zhang, J | 1 |
| Chen, D; Genetta, T; Jiang, YJ; Li, WL; Wei, L; Yu, SP; Yu, SS | 1 |
| Kim, HJ; Kim, JM; Kim, YJ; Lee, KY; Lee, SG; Park, JE; Yoo, YH | 1 |
| Du, Y; Guo, J; Han, S; Hong, Y; Huang, L; Li, Y; Liu, Y; Tang, D; Wang, Y; Yu, B; Zhao, J | 1 |
| Chang, Z; Guo, H; Guo, X; Jia, X; Jin, J; Luo, F; Shi, G; Song, Y | 1 |
| Liang, LZ; Liang, YJ; Liao, GQ; Liu, HC; Ma, B; Su, YX; Zheng, GS | 1 |
| Chao, CM; Cheng, BC; Hsu, SF; Huang, WT; Lin, MT | 1 |
| Dai, L; Di, W; Qi, Y; Xia, P; Zhang, N | 1 |
| Dickman, MB; Kabbage, M; Williams, B | 1 |
| Cao, H; Dai, C; Fang, L; He, W; Jiang, L; Wen, P; Yang, J; Zhou, Y | 1 |
| Hu, LF; Liu, CF; Liu, L; Mao, CJ; Yang, F; Yang, YP; Zheng, HF | 1 |
| Amarnath, S; Dropulic, B; Felizardo, TC; Foley, J; Fowler, DH; Medin, JA; Steed, K | 1 |
| Arsikin, K; Harhaji-Trajkovic, L; Janjetovic, K; Kostic-Rajacic, S; Misirkic-Marjanovic, M; Schrattenholz, A; Soskic, V; Tovilovic, G; Trajkovic, V; Vucicevic, L; Zogovic, N | 1 |
| Cho, ED; Cho, SG; Kim, JH; Lee, HJ; Lee, KW; Lee, SJ | 1 |
| Chen, J; Chen, S; Li, YQ; Lin, YM; Qing, Y; Wang, M; Wu, D | 1 |
| Lamoureux, F; Zoubeidi, A | 1 |
| Almasan, A; Hill, BT; Kalaycio, M; Mazumder, S; Sharma, A; Singh, K | 1 |
| Chen, Z; Lin, H; Liu, H; Sun, Q; Yuan, G; Zhang, L; Zhou, Q | 1 |
| Kandadi, MR; Ren, J; Roe, ND | 1 |
| Huanxing, S; Jingsong, O; Ruxun, H; Xicui, S; Xingyong, C; Xu, Z; Yi, H; Zhong, P | 1 |
| Chen, Y; Liu, J; Liu, T; Sun, L; Tian, X; Zhao, L; Zhong, J | 1 |
| Ariizumi, T; Endo, N; Fujiwara, T; Hotta, T; Kawashima, H; Kuwano, R; Li, GD; Ogose, A; Urata, Y | 1 |
| Dionísio, PA; Fonseca, MB; Rodrigues, CM; Solá, S; Xavier, JM | 1 |
| Ahnn, J; Kim, DH; Kwak, TH; Lee, SK; Lim, Y; Oh, HJ; Park, SM; Park, WJ; Shin, BH; Song, WK | 1 |
| Cheng, ML; Chiu, DT; Ho, HY; Lai, YC; Lin, HY | 1 |
| Chen, S; Feng, D; Han, T; Jiang, R; Liu, X; Ma, Y; Qiao, H; Wei, Y; Wu, L; Zhang, J; Zhang, S; Zhang, Y; Zhu, X | 1 |
| Cheng, PC; Chiang, WF; Hong, WZ; Lee, SY; Lin, MH; Lin, PY; Liu, SY; Liu, YC; Yen, CY | 1 |
| Chen, Z; Cheng, Y; Gao, J; Hu, WW; Shen, Y; Shen, Z; Wang, G; Wang, RR; Wang, X; Yan, H; Yuan, Y; Zhang, X | 1 |
| Boncoraglio, A; Carra, S; Crippa, V; Cristofani, R; Giorgetti, E; Poletti, A; Rusmini, P | 1 |
| Jeong, SJ; Jung, JH; Kim, B; Kim, SH; Sohn, EJ; Yun, SM | 1 |
| Abais, JM; Boini, KM; Chen, Y; Li, PL; Li, X; Riebling, CR; Wei, YM; Xu, M; Zhang, Y | 1 |
| Aligny, C; Bekri, S; Brasse-Lagnel, C; Genty, D; Gonzalez, BJ; Laquerrière, A; Lesueur, C; Marret, S; Roux, C | 1 |
| Chen, CY; Chen, MF; Chiang, CH; Hsu, HC | 1 |
| Chang, JY; Chen, KL; Cheung, CHA; Huang, CC | 1 |
| Li, W; Liu, JG; Qi, XK; Qian, HR; Xia, DY; Yao, S | 1 |
| Choi, YH; Hyun, JW; Kang, KA; Kim, AD; Kim, DH; Kim, HS; Lee, SJ | 1 |
| Choi, YJ; Lee, BH; Lee, K; Lee, KY; Oh, S; Oh, SH; Yang, MJ; Yang, YS | 1 |
| Bruserud, Ø; Hatfield, KJ; Nepstad, I; Reikvam, H | 1 |
| He, Y; Liu, M; Zhang, J | 1 |
| Chao, MR; Chen, JL; Hu, CW; Lee, H; Li, YJ | 1 |
| Hou, LL; Hu, GQ; Xie, SQ; Xu, QJ | 1 |
| Chwa, M; Franco, MF; Kenney, MC; Kuppermann, BD; Limb, A; Pham, K; Ramírez, C | 1 |
| Hu, HY; Kuo, SH; Lee, YR; Lei, HY; Lin, YS; Liu, CC; Liu, HS; Yeh, TM | 1 |
| Caro-Maldonado, A; Galindo-Moreno, J; Iurlaro, R; León-Annicchiarico, CL; Muñoz-Pinedo, C; Prehn, JHM; Ramírez-Peinado, S; Ryan, KM | 1 |
| Cecconi, F; Ciarlo, L; D'Amelio, M; Malorni, W; Marinelli, S; Nazio, F; Pavone, F; Pieroni, L; Tinari, A; Urbani, A; Vacca, V | 1 |
| Benavides, GA; Darley-Usmar, V; Dodson, M; Liang, Q; Zhang, J | 1 |
| Chao, MR; Chen, JL; Hsu, YW; Hu, CW; Tam, LM | 1 |
| Deng, W; Fan, Q; Gao, L; Han, Z; Jing, Y; Kou, X; Li, R; Sun, K; Wei, L; Wu, M; Ye, F; Yu, G; Zhao, Q; Zhao, X | 1 |
| Cai, Y; He, L; He, X; He, Y; Luo, J; Wu, X; Zhang, G; Zhang, Z | 1 |
| Bincoletto, C; Hirata, H; Pereira, GJ; Smaili, SS; Tressoldi, N | 1 |
| Chai, K; Ikejima, T; Liu, JH; Liu, Y; Onodera, S; Tashiro, S | 1 |
| Feng, J; Leng, X; Li, J; Li, W; Lian, S; Wang, C; Wang, H; Zhang, X | 1 |
| Huang, S; Jiang, L; Li, K; Li, W; Zhang, B; Zhang, D; Zhang, S; Zhang, W; Zheng, P | 1 |
| Chen, SF; Ma, KG; Shao, ZW; Wang, BC; Wang, J; Wu, Q; Xiong, LM; Yang, SH | 1 |
| Chang, J; Hu, Y; Wang, M; Wang, W; Yin, Z; Zhang, H | 1 |
| Okano, M; Sakata, N; Takemura, T; Ueda, S | 1 |
| Hirano, A; Kitaoka, Y; Kojima, K; Munemasa, Y; Takagi, H; Ueno, S | 1 |
| Chen, WH; Cheng, C; Cheng, J; Ren, JH; Wu, HG; Zhao, YX; Zhu, F | 1 |
| Chang, H; Chen, ML; Fu, YJ; Jin, X; Liang, XY; Mi, MT; Xie, Q; Yi, L; Zhang, QY; Zhang, T; Zhou, X; Zhou, Y; Zhu, JD | 1 |
| Bally, MB; Donohue, E; Dragowska, WH; Gelmon, KA; Gorski, SM; Kapanen, AI; Qadir, MA; Rawji, JS; Roberge, M; Wang, JC; Warburton, C; Weppler, SA; Wong, LY | 1 |
| Chen, MK; Chiou, HL; Hsieh, MJ; Lin, CW; Sheu, GT; Yang, SF; Yu, YY | 1 |
| Cho, KH; Kwon, KB; Lee, KK; Lee, SY; Lee, YR; Moon, SR; Park, JH; So, HS; Yang, SH | 1 |
| Chen, JY; Chen, WJ; Chu, LW; Huang, LY; Huang, YL; Lee, CH; Lee, JH; Lin, YH; Ping, YH; Xiang, R | 1 |
| Foggetti, G; Fronza, G; Gold, B; Inga, A; Menichini, P; Monti, P | 1 |
| Angeletti, M; Bonfili, L; Cecarini, V; Cuccioloni, M; Eleuteri, AM; Keller, JN; Mozzicafreddo, M; Rossi, G | 1 |
| Gao, XL; Jin, FG; Lin, P; Liu, QP; Pan, L; Zhou, DX | 1 |
| Wang, Y; Yin, W; Zhu, X | 1 |
| Chen, J; Dong, X; Gou, H; Liao, M; Liu, W; Luo, Y; Pei, J; Wang, J; Ye, Z; Yi, L; Zhao, M | 1 |
| Cheng, X; Guo, HP; Li, HH; Liang, W; Liao, YH; Long, Q; Wang, M; Wen, S; Yu, M; Yuan, J | 1 |
| Cederbaum, AI; Wu, D | 1 |
| Eichman, BF; Mullins, EA; Rubinson, EH | 1 |
| Chen, M; Chen, N; Hu, M; Huang, H; Li, M; Li, P; Miao, H; Zhao, R | 1 |
| Cheng, CC; Chiu, TH; Huang, YT; Lai, PC; Lin, TC | 1 |
| Chen, H; Dong, Y; Feng, SS; Jiang, Y; Li, X; Liang, X; Mei, L; Tao, W; Zeng, X; Zhang, X | 1 |
| Choi, D; Choi, J; Jo, M; Kim, HJ; Lee, E | 1 |
| Dai, J; He, Q; Li, Y; Luo, P; Wang, J; Wu, H; Yang, B; Yang, X | 1 |
| Choi, EJ; Kee, SH | 1 |
| Duan, QH; Li, J; Lu, QP; Lu, T; Luo, P; Tang, ZZ; Wang, ZQ; Wu, JP; Yang, Y | 1 |
| Bishayee, K; Ghosh, S; Khuda-Bukhsh, AR | 1 |
| Chang, HC; Chang, SC; Chiang, CK; Chou, CT; Chuang, YT; Ho, IL; Hsu, CH; Huang, KH; Kuo, KL; Lee, PY; Lin, WC; Liu, SH; Pu, YS | 1 |
| An, HK; Kim, CH; Kim, KS; Lee, JW; Lee, YC; Moon, HI | 1 |
| Chang, YF; Hsieh, YC; Kuo, PL; Lee, PH; Lin, CW; Lo, S; Perng, DS; Wu, DB; Yu, ML; Yuan, SS | 1 |
| Figueredo, VM; Inamura, Y; Kaneda, K; Koshinuma, S; Minami, T; Miyamae, M; Momota, Y; Onishi, A; Shiomi, M; Takemura, G | 1 |
| Chang, J; Cheng, L; Ji, D; Li, J; Liu, R; Liu, X; Sun, Z; Wang, C; Wang, S; Wang, X; Zhang, X; Zhang, Z; Zheng, B; Zheng, R | 1 |
| Dai, C; Fang, L; He, W; Li, X; Luo, Y; Yang, J | 1 |
| Gao, M; Jiang, B; Jiang, Y; Li, Y; Liu, Y; Lu, Q; Tong, Z; Xiao, X; Yao, Y; Zhang, L | 1 |
| Hu, N; Jiang, S; Ren, J; Xiong, L; Yang, J; Yang, L; Zou, Y | 1 |
| Huang, J; Li, Q; Sun, X; Wang, H; Zhang, T | 1 |
| Choi, S; Lim, HJ; Shin, H; Song, H | 1 |
| Chen, R; Fan, X; Gong, Y; Han, L; Jiang, L; Kong, X; Li, X; Wang, Z; Xiao, J; Zhang, H; Zhu, H | 1 |
| Broxmeyer, HE; Huang, X; Lee, MR; Messina-Graham, S; Ou, X | 1 |
| Gay, RE; Gay, S; Kato, M; Klein, K; Ospelt, C | 1 |
| Degtyarev, M; Lin, K; Reichelt, M | 1 |
| Cai, L; Cui, S; Kan, G; Lin, L; Sun, W; Tang, Q; Xu, C; Yu, C; Zhao, S | 1 |
| Folz, RJ; Stepp, MW; Yu, J; Zelko, IN | 1 |
| Cai, JP; Jiang, P; Lan, Y; Li, J; Liu, DG; Liu, J; Luo, J; Pang, JX; Ren, YL; Wang, C | 1 |
| Cao, L; Gao, L; Jiang, T; Shi, JQ; Tan, L; Tan, MS; Wang, HF; Yu, JT; Zhang, QQ; Zhang, YD; Zhu, XC | 1 |
| Lin, JH; Liu, WG; Muharram, A; Wang, ZY | 1 |
| Chung, HY; Hwang, SY; Jang, JY; Kang, YJ; Kim, DH; Kim, M; Kim, ND; Lee, Y; Lim, HS; Sung, B; Yoon, JH | 1 |
| Jeong, K; Jo, HJ; Kwon, KB; Lee, KK; Lee, S; Lee, SY; Lee, YR; Moon, SR; Park, JH; So, HS; Yang, SH | 1 |
| Chen, G; Chu, Y; Du, L; Jiang, N; Lin, W; Qian, J; Wang, G; Zhang, Y; Zheng, J | 1 |
| Barbosa, CM; Bincoletto, C; Jurkiewicz, A; Palmeira dos Santos, C; Pereira, GJ; Smaili, SS | 1 |
| Ahmad, S; Alam, MJ | 1 |
| Gu, WD; Huang, J; Jiang, RY; Pei, HL; Wang, ZG | 1 |
| Bu, BT; Chen, B; Gui, MC; Yu, SS | 1 |
| Chatterjee, C; Sparks, DL | 1 |
| Chen, D; Deng, X; Ding, W; Long, F; Rui, W; Wang, L; Zhang, F; Zhao, Y | 1 |
| Hergert, P; Nho, RS | 1 |
| Gao, S; Hao, J; Huang, H; Ji, W; Ren, H; Zhao, X | 1 |
| Devine, A; Kacprzyk, J; McCabe, PF | 1 |
| Gao, S; Gao, Y; Liu, P; Lu, J; Sun, D; Ye, J | 1 |
| Hsu, SC; Hsu, YJ; Huang, SM; Lee, HS; Lin, CY; Lin, SH; Shih, CC; Tsai, CS | 1 |
| Cao, G; Cao, Z; Guo, Z; Kou, J; Li, L; Yang, H; Yu, B; Zhou, H | 1 |
| Bao, LJ; Jaramillo, MC; Yao, M; Yi, XF; Zhang, DD; Zhang, ZB; Zheng, YX | 1 |
| Feng, H; Yang, Z; Zhang, JH; Zhao, TZ; Zou, YJ | 1 |
| Clarke, R; Kedir, H; Kumar, D; Ramalinga, M; Tran, AT | 1 |
| Dull, RO; Hu, G; Liu, G; Schwartz, DE; Zhang, Y | 1 |
| Chen, W; Li, S; Peng, W; Sun, H; Wu, J; Yang, X; Yu, X; Zeng, Y | 1 |
| Chen, ZR; Huang, M; Min, H; Xu, M; Zheng, K; Zhou, JD; Zou, XP | 1 |
| Lin, C; Lin, L; Shen, H; Yang, Z; Yuan, B; Zhang, N | 1 |
| Li, R; Liu, WT; Song, JR; Sun, K; Wei, LX; Wu, MC; Zhang, JW; Zhang, SS; Zhao, QD; Zong, C | 1 |
| Babcock, SA; Guo, Y; He, W; Li, C; Li, N; Li, Y; Liu, M; Ma, M; Shen, M; Sun, D; Wang, H; Wang, J; Yu, W; Zeng, C; Zhang, R; Zhang, Y; Zou, Q | 1 |
| Duan, R; Gao, H; Jia, Y; Li, Y; Peng, T; Teng, J; Wang, C; Wang, X; Zhang, G | 1 |
| Li, C; Liu, Q; Shi, X; Wang, D; Wang, L; Zhou, X | 1 |
| Cai, W; Cheng, Y; Dang, S; He, X; Jin, M; Li, Q; Peng, Y; Wan, B; Wang, RX; Wu, C; Xu, C; Xu, H; Zhang, Y | 1 |
| Chen, WC; Ho, CT; Hsu, KY; Hung, CM; Kuo, SC; Lin, YC; Way, TD; Yang, NS | 1 |
| Aleo, MF; Corsetti, G; Ferroni, M; Lavazza, A; Rovetta, F; Sberveglieri, G; Stacchiotti, A | 1 |
| Li, Z; Wei, M; Yang, Z | 1 |
| Hu, C; Liu, J; Tian, Y; Tian, Z; Wang, C; Wang, X | 1 |
| Chen, C; Cheng, X; Fang, L; Jiang, CC; Jiang, ZW; Liu, H; Zhang, XD | 1 |
| Chen, X; Fan, B; Jiao, YY; Li, GY; Su, GF; Wang, WJ; Zhang, TZ | 1 |
| Ivanov, I; Kossmann, B | 1 |
| Aiastui, A; Bravo-San Pedro, JM; Climent, V; Fuentes, JM; Gómez-Sánchez, R; González-Polo, RA; López de Munain, A; Pizarro-Estrella, E; Rodríguez-Arribas, M; Yakhine-Diop, SM | 1 |
| Chen, J; Cheng, D; Fu, J; Li, Z; Liang, Y; Liu, H; Liu, L; Ni, M; Yao, J; Zhang, H; Zhang, J; Zhang, Y; Zhou, J; Zou, Z | 1 |
| Tang, S; Wang, C; Xiao, X; Zhang, C; Zhang, S; Zhao, D; Zhou, Y | 1 |
| An, Q; Hu, X; Huang, X; Liu, Z; Mu, S; Zhan, Y; Zhang, X | 1 |
| Darley Usmar, VM; Dodson, M; Giordano, S; Ouyang, X; Ravi, S; Redmann, M; Zhang, J | 1 |
| Chen, J; Fan, LL; Li, CL; Li, LJ; Wang, B; Wei, HL; Xie, B | 2 |
| Li, X; Su, J; Wang, K; Zhang, T; Zhu, T | 1 |
| Dong, J; Jiang, L; Jiang, Y; Jin, Y; Wang, H | 1 |
| Jiao, Y; Ju, Y; Li, W; Liu, Y; Wang, S; Wang, Y; Zhang, B; Zhang, J; Zhang, M; Zhao, L; Zhao, M; Zhao, Y | 1 |
| Chen, Y; Gong, F; Jiang, Y; Liao, H; Liu, J; Peng, X; Wang, M; Xiao, G; Yu, M; Zhang, S | 1 |
| Khodagholi, F; Motamedi, F; Shaerzadeh, F | 1 |
| Fox, HS; Purnell, PR | 1 |
| Bai, L; Chen, Y; Duan, Z; Han, Y; Jiao, M; Ren, F; Shi, H; Wang, X; Wei, L; Wen, T; Zhang, J; Zhang, L; Zhang, X; Zhao, C; Zheng, S; Zhou, L | 1 |
| Gao, Q; Geng, L; Jiang, L; Liu, H; Shi, B; Yang, F; Yao, Y; Zhang, X | 1 |
| Deborah, B; Fan, QC; Jiang, HQ; Jiang, LC; Li, KY; Liu, XB; Xin, ZY; Xu, K; Yuan, DY; Zhang, B; Zhang, JS | 1 |
| Jiang-Shieh, YF; Lan, SH; Lin, CN; Liu, HS; Su, CL; Won, SJ; Wu, SY; Yen, CH | 1 |
| Du, J; Gu, C; Hua, S; Huang, J; Liu, F; Wang, J; Yang, L; Yu, J; Yuan, X; Zhang, H | 1 |
| Abramowsky, C; Anania, F; Gupta, NA; Jiang, R; Kirk, AD; Kolachala, VL; Kosters, A; Pavuluri, H; Shenoi, A | 1 |
| Cao, J; Chen, Q; Cui, F; Gao, H; Gu, Y; Jiao, Y; Liu, W; Qi, D; Wu, A; Wu, S; Xia, X; Zhang, X; Zhu, W | 1 |
| Bunai, Y; Chen, H; El-Kabbani, O; Endo, S; Hara, A; Ikari, A; Matsunaga, T; Nishiyama, A; Soda, M; Suyama, M; Tajima, K; Takemura, M | 1 |
| Fernández Pazos, Mde L; Hermann, R; Marina Prendes, MG; Mestre Cordero, VE; Perazzo Rossini, JC; Rusiecki, TM; Savino, EA; Varela, A; Vélez, DE | 1 |
| Chang, JM; Chen, CA; Chen, HC; Cheng, YC | 1 |
| Feng, Q; Gan, J; Jiang, Y; Ouyang, Y; Yu, M | 1 |
| Chen, W; Fang, Y; Han, W; Jin, W; Lou, F; Lou, H; Pan, H; Sui, X; Wang, K; Wang, X; Xu, Y; Zheng, Y | 1 |
| Allanki, AD; Navale, R; Sijwali, PS | 1 |
| Lan, D; Wang, W; Zhao, Z; Zhuang, J | 1 |
| Albert, F; Meske, V; Ohm, TG; Priesnitz, T | 1 |
| Akin, D; Boulton, M; Bowes Rickman, C; Ding, J; Dunn, W; Grant, M; Lewin, A; Mao, H; Mitter, SK; Qi, X; Rao, H; Song, C | 1 |
| Cao, L; Chuai, M; Lee, KK; Li, S; Li, Y; Lu, WH; Song, XY; Wang, G; Wang, XY; Yang, X | 1 |
| Davies, DM; Errington, RJ; Herbert, TP; Hunt, DK; Johnson, CE; Sampson, JR; Tee, AR; Wiltshire, M | 1 |
| Bresgen, N; Eckl, PM; Krenn, MA; Schürz, M; Teufl, B; Uchida, K | 1 |
| Chen, D; Feng, X; Guo, H; Han, Y; Li, N; Shi, Y; Wang, A; Xie, F | 1 |
| Cho, DH; Choi, EK; Hwang, JJ; Jeong, SY; Kim, CS; Kim, DE; Kim, SB; Kim, Y; Koh, JY; Lee, JS; Suh, N | 1 |
| Huang, SS; Huang, YS; Li, IH; Liang, CM; Ma, KH; Weng, SJ | 1 |
| Chen, M; Geng, CY; Jiang, LP; Li, QJ; Liu, XF; Liu, YN; Sun, XC; Wang, YX; Yang, G; Yao, XF | 1 |
| Liu, S; Liu, X; Liu, Z; Niu, Z; Sun, L; Wang, H; Xie, F | 1 |
| Di, W; Li, W; Tang, Z; Zhang, N | 1 |
| Chen, G; Gao, M; Jiang, Y; Lang, Y; Liu, M; Tong, Z; Wang, K; Wang, W; Xiao, X; Yao, Y; Zhang, H | 1 |
| Ding, W; Jiang, G; Li, J; Li, L; Lu, Z; Wang, J; Zhang, L; Zhao, Y | 1 |
| Cheng, J; Feng, S; Li, G; Liang, J; Liu, S; Quan, M; Wang, Q; Zhang, Y | 1 |
| Ji, W; Panus, D; Wang, C; Zhong, X | 1 |
| Xian, R; Yang, Z; Yuan, B; Zhong, L; Zhong, S | 1 |
| Bie, M; Cui, Q; Lv, Y; Ren, C; So, KF; Xiao, J; Xing, F | 1 |
| Deng, H; Ji, A; Liu, L; Liu, X; Peng, X; Wu, Z; Xu, Q; Zhang, J; Zuo, X | 1 |
| Boratyn, E; Durbas, M; Gaik, M; Horwacik, I; Kołoczek, H; Rokita, H; Szczodrak, M; Szychowska, K; Zając, G | 1 |
| Anoopkumar-Dukie, S; Bernaitis, N; Chess-Williams, R; Christie, D; Davey, AK; Forbes, A; McDermott, CM; McFarland, AJ; Perkins, AV; Pickard, RD; Spencer, BH | 1 |
| Bi, Y; Chen, X; Cho, K; Hou, X; Li, C; Liu, H; Liu, Y; Peng, F; Shen, C; Wang, K; Wang, X; Yang, Z; Zhang, J; Zhang, W; Zhang, X; Zhao, S; Zheng, Z; Zhong, C; Zou, H | 1 |
| Gao, N; Li, Z; Wang, H; Yang, Z; Zhang, T | 1 |
| Engedal, N; Hagen, LK; Saetre, F; Seglen, PO | 1 |
| Godschalk, RW; Jutten, B; Keulers, TG; Peeters, HJ; Rouschop, KM; Savelkouls, KG; Schaaf, MB; van den Beucken, T; van Schooten, FJ; Vooijs, M | 1 |
| Ambrose, E; Chen, S; Cunnington, RH; Dixon, IM; Filomeno, KL; Freed, DH; Ghavami, S; Gupta, S; Halayko, AJ; Klonisch, T; Singal, R; Yeganeh, B | 1 |
| Arnould, T; Cambier, P; Cote, F; Fransolet, M; Leclere, L; Michiels, C; Van Cutsem, P | 1 |
| Aligny, C; Bekri, S; Brasse-Lagnel, C; Brunel, V; Driouich, A; Genty, D; Girault, V; Gonzalez, BJ; Laquerrière, A; Lesueur, C; Marret, S; Ramdani, Y; Roux, C | 1 |
| Chen, M; Hu, Q; Huang, J; Liang, X; Mi, M; Shi, L; Zhang, Q; Zhang, T; Zhou, Y; Zhu, J | 1 |
| Chang, YT; Huang, HJ; Hwang, MH; Lin, AM; Tang, MC; Wu, MY; Yang, JC | 1 |
| Chen, Q; Deng, L; Gao, M; Hu, G; Lu, Q; Luo, S; Rao, H; Shao, J; Shi, C; Tang, X; Wang, Y; Xu, R | 1 |
| Chao, MR; Hsu, YW; Hu, CW; Lin, JH; Liu, HH | 1 |
| Chang, H; Chen, Q; Wang, R; Zhang, R | 1 |
| Chen, LH; Lu, MH; Ma, QH; Wang, W; Wu, H; Xia, YY; Xu, RX; Yang, Y; Zhang, MY; Zhu, QQ | 1 |
| Jiang, J; Jiang, S; Liang, L; Liu, S; Liu, X; Nie, X; Tang, C; Wan, C; Xi, H; Yang, J; Zhao, J | 1 |
| Chang, F; Li, WJ; Liu, J; Liu, PP; Miao, JY; Yue, HW; Zhao, J | 1 |
| Chen, Y; Guo, L; Hao, D; He, C; Li, X; Wu, X; Xiao, Y; Yang, Y; Zhang, S | 1 |
| Cui, LY; Yang, S; Zhang, J; Zhang, YL | 1 |
| Chen, DX; Chen, Y; Duan, ZP; Lou, JL; Ren, F; Shi, HB; Shi, HL; Sun, HQ | 1 |
| Li, G; Li, M; Li, Z; Liu, P; Liu, Y; Liu, Z; Ma, L; Shao, W; Sui, D; Wang, B | 1 |
| Dai, H; Du, Y; Guan, X; Qian, J; Qian, Y; Shen, Y; Yan, Y; Zhang, L | 1 |
| Britschgi, A; Cahill, MR; Gudas, LJ; McKenna, SL; Mongan, NP; Nyhan, MJ; O'Donovan, TR; Orfali, N; Tschan, MP | 1 |
| Chen, K; Duan, WM; Gong, FR; Gui, Q; Li, DM; Li, W; Lian, L; Liu, L; Shen, M; Tao, M; Wang, WJ; Wu, MY; Xu, MD; Zhu, J | 1 |
| Buch, S; Cai, Y; Callen, SE; Guo, ML; Liao, K; Periyasamy, P; Yang, L | 1 |
| Huang, HJ; Lin, AM; Tai, YI; Teng, YC | 1 |
| Hao, G; Liu, J; Sun, TS; Yi, L | 1 |
| Bouderlique, T; Chagin, AS; Kaminskyy, VO; Newton, PT; Ohlsson, C; Vuppalapati, KK; Wehtje, H; Zhivotovsky, B | 1 |
| He, J; He, W; Liao, M; Wang, H; Yang, C; Zhao, W | 1 |
| Aki, T; Funakoshi, T; Hashimoto, K; Uemura, K; Unuma, K | 1 |
| Cai, GQ; Chen, XD; Gu, W; Peng, JP; Shen, C | 1 |
| Chen, M; Huang, Z; Li, Y; Liu, B; Liu, P; Luo, C; Ou, C; Wu, Z; Zhang, J | 1 |
| Cai, S; Gao, Y; Qu, L; She, T; Shou, C; Su, Y; Wang, L; Xu, S; Zhao, C | 1 |
| Engedal, N; Seglen, PO | 1 |
| Chen, H; Hu, K; Ruan, Y | 1 |
| Ko, T; Li, M; Li, S | 1 |
| Cai, D; Hua, D; Mao, Y; Wang, F; You, Q | 1 |
| Cui, B; Hu, ZW; Hua, F; Huang, B; Jiang, JD; Li, K; Lin, H; Lv, XX; Mu, R; Shang, S; Sun, W; Wang, F; Yan, J; Yu, JJ; Zhang, XW | 1 |
| Diao, Z; Liu, W; Wang, L; Wu, Y; Zhang, Y | 1 |
| Fan, J; Ju, D; Li, L; Lin, C; Liu, J; Liu, Z; Nie, D; Tao, Q; Wu, J; Zhao, S | 1 |
| Hsieh, YH; Hsueh, JT; Lee, CH; Lin, CL; Tsai, JP; Ying, TH | 1 |
| Du, Y; Hao, H; Li, Y; Liu, H; Lv, T; Wang, J; Wang, L; Wang, X; Zhang, S; Zuo, L | 1 |
| Cha, BK; Hwang, KE; Jeong, ET; Jung, JW; Kim, HR; Kim, YS; Kwon, SJ; Oh, SH; Park, DS; Yoon, KH | 1 |
| Chen, X; Chen, YH; Jiang, PF; Li, LJ; Li, W; Shen, HQ; Zheng, XY | 1 |
| Mori, T; Mori, Y; Rai, T; Sohara, E; Uchida, S; Wakabayashi, M; Yoshizaki, Y; Zeniya, M | 1 |
| Chen, Y; Gao, F; Lu, B; Shi, G; Wang, B; Xu, H; Zhang, Y; Zheng, F; Zhong, S | 1 |
| Li, J; Li, Y; Piao, S; Saiyin, W; Sun, H; Wang, W; Yang, D; Zheng, C; Zhou, J | 1 |
| Gao, N; Li, W; Wang, H; Yang, Z; Zhang, T | 1 |
| Inoue, Y; Moriyasu, Y; Mukae, K; Niwa, Y; Yanagisawa, T; Yano, K | 1 |
| Atarashi, R; Fuse, T; Homma, T; Ishibashi, D; Nakagaki, T; Nishida, N; Sano, K; Takatsuki, H | 1 |
| Ito, M; Kakutani, K; Kurakawa, T; Kuroda, R; Kurosaka, M; Maeno, K; Matsushita, T; Miyazaki, S; Nishida, K; Takada, T; Terashima, Y; Ueha, T; Yurube, T; Zhang, Z | 1 |
| Bae, SY; Hong, YA; Ko, GJ; Kwon, YJ; Pyo, HJ | 1 |
| Gao, J; Huang, D; Zhou, H | 1 |
| Chen, L; Wang, J; Zhang, J; Zhang, L | 1 |
| Bao, Y; Chao, Y; Hamilton, CJ; He, Y; Li, B; Liu, R; Roberts, AA; Sexton, DW; Shan, Y; Wang, W; Wileman, T; Yu, G | 1 |
| Alarcón, C; Ali, A; Boland, BB; Rhodes, CJ | 1 |
| Barui, AK; Hu, Y; Jin, PP; Lin, J; Patra, CR; Ruan, RQ; Shi, SS; Wei, PF; Wen, LP; Zhang, HR; Zhang, JQ; Zhang, L; Zhang, YJ; Zhou, W | 1 |
| Chen, H; Ling, H; Meng, X; Wei, M; Xie, K; Yu, Y | 1 |
| Cai, W; Di, W; Ji, Y; Lu, Z; Wu, J; Yang, Q | 1 |
| Bi, Y; Gao, D; Hou, X; Li, C; Liu, H; Liu, Y; Liu, Z; Peng, F; Shen, C; Shi, C; Wang, K; Wang, X; Wu, J; Zhang, J; Zhao, B; Zhao, S; Zheng, Z; Zhong, C; Zou, H | 1 |
| Dong, X; Li, J; Li, T; Liu, F; Liu, J; Wang, F; Wei, H; Xiu, P; Xu, Z; Zhong, J | 1 |
| Choi, SK; Jung, M; Kim, H; Kim, HS; Moon, WK; Sun, Y; Tian, L | 1 |
| Cai, YC; Jiang, WQ; Li, S; Wang, KF; Yang, H | 1 |
| Cederbaum, AI; Lu, Y | 1 |
| Münz, C; Nytko, KJ; Reichenbach, J; Romao, S; Siler, U; Tejera, E | 1 |
| Gao, J; Guo, Y; Han, A; Hao, A; Liu, S; Wang, L; Zhang, X | 1 |
| Ding, K; Li, T; Wang, H; Wu, Y; Xu, J; Zhang, L | 1 |
| Du, J; Li, J; Liu, J; Liu, X; Wang, R; Wang, W; Wang, X; Yang, Q; Zhu, J | 1 |
| Gao, GY; Jiang, JY; Jin, Y; Lei, J; Lin, Y | 1 |
| Hwang, H; Jeong, HJ; Jeong, HS; Kim, HS; Kim, M; Kwon, J; Lim, S; Oh, PS; Sohn, MH | 1 |
| Bao, N; Chen, J; Dong, L; Gan, J; Guo, T; He, W; Huang, Z; Liu, K; Liu, N; Shi, T; Wang, L; Wang, R; Wang, Z; Zhang, J; Zhao, J; Zhou, G | 1 |
| Chen, LC; Huang, YS; Kao, TJ; Li, IH; Lin, YY; Ma, KH; Weng, SJ; Yen, TY | 1 |
| Chen, G; Fan, W; Lai, Y; Long, Y; Wang, X; Zhu, B | 1 |
| Bao, W; Gu, Y; Ta, L; Wang, K; Xu, Z | 1 |
| Huangfu, CS; Ji, AL; Li, YZ; Liu, B; Zhang, YJ; Zheng, NR | 1 |
| Khan, FA; Li, S; Zhang, S; Zhou, A | 1 |
| Lee, CG; Lee, E; Lee, HK; Pyo, S; Yim, JH | 1 |
| Busuttil, RW; Kupiec-Weglinski, JW; Lu, L; Wang, X; Yue, S; Zhai, Y; Zhou, H; Zhu, J | 1 |
| Chai, J; Chen, D; Guo, H; Kou, B; Shi, Y; Yan, X; Zhu, Z | 1 |
| Lin, L; Shen, H; Su, T; Yang, Z; Yuan, B; Zhong, L | 1 |
| Huang, K; Liu, D | 1 |
| Arumugam, A; Bonkoungou, S; Camacho, F; Dwivedi, Ak; Gonzalez, E; Gonzalez, V; Lakshmanaswamy, R; Medel, J; Nandy, S; Narayan, M; Ortega, A; Subramani, R | 1 |
| Barton, LA; Chen, Y; Fuller, ND; Guo, R; Henion, JM; Hu, N; Pang, J; Ren, J | 1 |
| Chen, G; Huang, Y; Jiang, C; Liu, H; Ma, L; Song, L; Sun, X | 1 |
| Chan, JC; Chi, SC; Tsai, PY; Wu, YC | 1 |
| Chan, WK; Chang, Y; Chao, CL; Cheng, SP; Cheng, YF; Chuang, CP; Ho, FM; Lee, KR | 1 |
| Bhattacharya, S; Chakrabarti, G; Das, A; Datta, S; Ganguli, A | 1 |
| Chen, S; Dai, H; Deng, Z; Du, H; Hei, TK; Liu, Y; Nie, Y; Wang, J; Wang, M; Wang, X; Wu, L; Xu, A | 1 |
| He, G; Li, C; Li, S; Su, S; Tan, X; Tong, L; Xu, W | 1 |
| Chen, K; Lv, Q; Yang, F; Zhang, Y | 1 |
| Meng, H; Yang, L; Yang, M | 1 |
| He, C; Kanazawa, T; Morita, K; Nakanishi, T; Song, Y; Tsukada, J; Wang, D; Yoshida, Y | 1 |
| Baek, E; Kim, CL; Kim, MG; Lee, GM; Lee, JS | 1 |
| Chang, CH; Chang, YJ; Chien, S; Hsueh, YY; Huang, HC; Li, YS; Shung, KK; Su, FC; Tang, MJ; Wang, SH; Wang, SW; Wu, CC | 1 |
| Andersen, PM; Birve, A; Forsgren, E; Gilthorpe, JD; Keskin, I; Lange, DJ; Marklund, SL; Synofzik, M; Weber, M | 1 |
| Duan, J; Liu, Q; Mu, H; Niu, H; Tang, J; Wang, D | 1 |
| Fang, Y; Guo, Y; Xue, Z | 1 |
| Chen, D; Hu, X; Hua, Q; Li, X; Lin, J; Liu, Y; Pan, C; Tan, F; Wan, Y; Zheng, L | 1 |
| Chen, X; Dong, W; Gao, Y; Luo, C; Ma, L; Shen, X; Tao, L; Wu, Q; Zhang, M | 1 |
| Gao, J; Hao, S; Li, Z; Yang, Z; Yin, H | 1 |
| Gabryel, B; Kasprowska, D; Kost, A; Machnik, G | 1 |
| Liu, T; Shao, J; Xia, W; Xie, QR; Yang, X; Zhang, T | 1 |
| Gao, R; Guo, J; Li, N; Ma, Z; Shi, S; Tan, P; Wang, J; Yan, B; Zhao, J | 1 |
| Cen, S; Chen, Z; Deng, H; Hou, J; Li, J; Li, W; Liu, Z; Ouyang, Y; Shen, H; Song, B; Wang, P; Wu, Y; Xie, Z; Yang, R | 1 |
| Apostolou, A; Garbis, SD; Giannogonas, P; Karalis, KP; Macari, SA; Manousopoulou, A; Pothoulakis, C; Psarras, S; Theocharis, S | 1 |
| Liu, N; Meng, J; Shi, T; Wang, Z; Zhao, J; Zhou, G | 1 |
| Peddinti, RK; Tomar, JS | 1 |
| Clarke, JP; Mearow, K | 1 |
| Wang, L; Wang, S; Zhao, S; Zhu, YR | 1 |
| Cai, J; Chen, Q; Fang, J; Huang, W; Song, J; Wang, J; Wang, M; Wang, Y; Xia, T; Yu, Z | 1 |
| Duan, Y; He, Y; Luo, X; Sun, G; Sun, X; Xu, H; Zhang, H | 1 |
| Cheng, NT; Guo, A; Meng, H | 1 |
| Duan, YQ; Li, NJ; Li, QX; Liu, J; Sun, JP; Wang, XJ; Wang, ZY; Yi, F; Yu, X; Zhang, C; Zhang, Y | 1 |
| Liang, T; Luo, Y; Meng, X; Sun, G; Sun, X; Wang, M; Zhao, J | 1 |
| Borneman, J; Cheema, AK; Dowdy, T; Fornace, AJ; Maier, I; Ruegger, PM; Schiestl, RH; Singh, R; Wang, Y | 1 |
| Lee, JH; Lee, YJ; Moon, JH; Park, SY | 2 |
| Chen, M; Deng, W; Fu, S; Guo, Z; He, X; Ju, W; Wang, D; Zhang, C; Zhao, Q | 1 |
| Hu, S; Kong, H; Li, X; Wang, H; Xie, W; Xu, R; Ye, L; Zeng, X | 1 |
| Cui, L; Jia, L; Liang, B; Liu, X; Ma, S; Song, Z | 1 |
| Bao, NR; Chen, FS; Fang, B; Li, XQ; Ma, H; Pi, XL; Tan, WF; Zhang, Y | 1 |
| Gu, HF; Li, HZ; Liao, DF; Tang, XQ; Tang, YL; Zheng, XL | 1 |
| Avvedimento, M; Boccella, N; Borzacchiello, D; Busiello, RA; Carotenuto, G; Cattaneo, F; Esposito, G; Feliciello, A; Lombardi, A; Magliulo, F; Oliveti, M; Paolillo, R; Perrino, C; Pironti, G; Pirozzi, M; Polishchuk, R; Schiattarella, GG; Sepe, M; Trimarco, B | 1 |
| Dong, Q; Gu, J; Li, L; Wang, C; Wei, X; Xu, F; Zhou, X; Zhou, Z | 1 |
| Cao, L; Chuai, M; Liu, L; Lu, WH; Ma, ZL; Münsterberg, A; Shi, YX; Song, X; Wang, G; Yang, X | 1 |
| Chen, D; He, J; Huang, Z; Liang, X; Mao, X; Tian, G; Yu, B; Yu, J; Zheng, P | 1 |
| Chen, RM; Chen, TL; Hsieh, MH; Lin, CJ; Lin, YW; Tseng, YY; Wu, GJ | 1 |
| Aschner, M; Ben, L; Changsheng, Y; Fang, L; Guangwei, X; Hai, Q; Jing, M; Rongzhu, L; Suhua, W; Wenjun, Z; Yu, B; Yuntao, F | 1 |
| Cai, M; Duan, Y; He, Y; Ke, J; Luo, X; Sun, G; Sun, X; Zhang, D; Zhang, H | 1 |
| Atuan, M; Beedle, AM; Call, JA; Foltz, SJ; Luan, J; Nichenko, AS; Peissig, KB; Southern, WM; Warren, GL | 1 |
| Bernstein, KA; Godin, SK; Herken, BW; Lee, AG; Mihalevic, MJ; Resnick, MA; Sobol, RW; Westmoreland, JW; Yu, Z; Zhang, Z | 1 |
| Bi, H; Gao, J; Lu, X; Zhang, G; Zheng, Y | 1 |
| Chen, XX; Huang, H; Liu, SS; Wang, LL; Wang, XR; Wang, XW; Wei, XM; Wu, JX | 1 |
| Chen, JH; Hsu, CC; Lee, MS; Lin, HH; Wang, CP | 1 |
| Huo, C; Jia, X; Li, H; Li, X; Liu, Y; Wang, L; Wang, N; Wang, X; Xia, T; Xia, Y; Xu, R; Zhang, M | 1 |
| He, KW; Huo, ZJ; Liu, ZY; Ma, QH; Song, XG; Wang, XW; Wang, XZ; Yu, ZY; Zhuo, PY | 1 |
| He, F; Luo, B; Qu, L; Song, X; Wang, J; Wang, K; Wei, R; Xu, Y | 1 |
| Cui, L; Yang, S; Zhang, J; Zhang, W | 1 |
| Deng, XW; Fang, JF; Yao, C; Zhang, YQ; Zhou, F; Zhou, XZ; Zhu, LQ; Zhu, YR | 1 |
| Li, Z; Yang, Z; Yin, H; Zhang, T; Zhang, X | 1 |
| Jin, J; Jin, L; Lim, SW; Yang, CW | 1 |
| Che, X; Chen, LC; Gao, J; Gu, J; Huang, C; Huang, H; Jin, H; Li, J; Li, Y; Lyu, J; Xie, Q; Zhang, L; Zhu, J | 1 |
| Chen, J; Connell, AR; Du, M; Fu, D; Hammad, SM; Lyons, TJ; Wu, M; Yang, S; Yu, JY | 1 |
| Chen, L; Li, Z; Wan, Q; Xin, W; Xu, Y; Yu, Y; Zhou, Q | 1 |
| Bisicchia, E; Cavallucci, V; D'Amelio, M; Latini, L; Molinari, M; Nicolin, V; Sasso, V; Viscomi, MT | 1 |
| Cheng, Z; Lin, M; Liu, H; Niu, H; Rikihisa, Y; Xiong, Q; Yamamoto, A | 1 |
| Bonora, M; Gafà, R; Giorgi, C; Kroemer, G; Lanza, G; Magri, E; Missiroli, S; Pandolfi, PP; Patergnani, S; Perrone, M; Pinton, P; Poletti, F; Raimondi, A; Tacchetti, C | 1 |
| Chen, L; Fang, Y; Fei, W; Han, W; Jing, Z; Liang, X; Pan, H; Sui, X; Xie, J; Zhang, L; Zhang, X; Zhou, J | 1 |
| Chen, LX; Ran, DH; Xie, WY; Yang, J; Zhou, XD | 1 |
| Chen, L; Fan, T; Geng, Q; Hu, H; Huang, Z; Mao, Z; Pan, S; Wang, W; Xu, Y; Zhang, B | 2 |
| Baek, HS; Chung, IK; Kim, BJ; Kim, CH; Kim, IR; Kim, SE; Park, BS; Shin, SH | 1 |
| Hee Kim, Y; Jun, do Y; Kim, JS; Kim, KY; Kim, YH | 1 |
| Bi, J; Gao, F; He, W; Huang, H; Lan, Y; Song, D; Wang, G; Zhang, D; Zhao, K | 1 |
| Jiang, ZF; Liu, RY; Shao, LJ; Wu, HM | 1 |
| Akhtar, S; Facskó, A; Fésüs, L; Kaarniranta, K; Kauppinen, A; Kristóf, E; Petrovski, G; Szatmári-Tóth, M; Veréb, Z | 1 |
| Chuang, SM; Liang, RY; Tan, X; Wang, HC | 1 |
| Bastos, ML; Carvalho, F; Carvalho, RA; Costa, VM; Gomes, AS; Pinto, M; Reis-Mendes, A; Remião, F; Sousa, E | 1 |
| Li, BW; Li, Z; Tang, J; Tao, JQ; Wang, JW; Wang, LJ; Wang, WZ; Wei, S; Xie, KL; Xu, H; Xu, ZK; Yang, L; Zhang, DC; Zhang, Q; Zhi, XF; Zhu, Y | 1 |
| Chen, M; Chen, T; Li, Y; Ren, H; Thakur, A; Wang, T; Yang, T; Zhang, S | 1 |
| Castro, PF; Chiong, M; Lavandero, S; Martínez, GJ; Pizarro, M; Troncoso, R | 1 |
| Averill-Bates, DA; Grondin, M; Kassis, S; Redza-Dutordoir, M; Ve, H | 1 |
| Chen, M; Peng, HY; Sha, LL; Wang, C; Wang, H; Zhao, MH | 1 |
| Chen, D; Chen, Y; Duan, Z; Ren, F; Shi, H | 1 |
| Esner, M; Graifer, D; Lleonart, ME; Lyakhovich, A | 1 |
| Ding, LL; Dou, CW; Jia, YL; Liu, QG; Liu, ZK; Tu, KS; Xu, M; Xue, YM; Yao, BW; Zheng, X | 1 |
| Kumar, P; Narwal, M; Peddinti, RK; Tomar, JS | 1 |
| Kim, KD; Lee, KW; Madhi, H; Oh, SS; Park, KH; Park, S; Ryu, HW; Yoo, J | 1 |
| Chen, S; Dong, Z; Gou, Y; Huang, G; Zhang, X; Zhao, Y | 1 |
| Chen, SF; Lo, WY; Wang, HJ | 1 |
| Chen, G; Chen, P; Di, C; Gong, L; Shi, J; Wang, J; Xia, X; Xu, H; Zhang, W | 1 |
| Cui, R; Ding, T; Gu, W; Guo, X; Han, F; Li, X; Peng, J; Xu, W | 1 |
| Cai, N; Chen, D; Feng, Y; Pan, Z; Tang, Q; Tian, N; Wang, C; Wang, Q; Wang, X; Wu, Y; Xia, D; Xu, D; Xu, H; Yan, M; Zhang, JJ; Zhang, X; Zhou, K; Zhou, Y | 1 |
| Fu, X; Guo, Y; Lin, C; Wu, S; Xia, W; Xu, P; Yao, M | 1 |
| Ding, S; Gao, D; Gao, M; Liu, S; Lv, J; Niu, Z; Wang, X; Wang, Z | 1 |
| Li, DY; Pan, DF; Wang, C; Xu, TD; Zhang, BC; Zhang, CW | 1 |
| Akao, Y; Kumazaki, M; Kuranaga, Y; Shinohara, H; Taniguchi, K; Tsujimura, N; Yamada, NO | 1 |
| Fang, Y; Jia, YP; Li, Q; Mao, XH; Tang, B; Wang, K; Zeng, DZ; Zhang, ZJ; Zhu, P | 1 |
| Guo, F; He, XB; Le, W; Li, S | 1 |
| Liu, X; Ren, G; Tian, K; Wang, Y; Xu, G; Xu, X; Xu, Z; Zhou, W | 1 |
| Fei, Y; Fu, X; Li, B; Li, W; Meng, X; Wei, X; Wu, Z; Zeng, M; Zheng, Y | 1 |
| Hayashi, T; Ikejima, T; Li, F; Liu, L; Liu, WW; Onodera, S; Tashiro, SI; Zheng, N | 1 |
| Casas, J; Casasampere, M; Fabrias, G; Ordóñez, YF | 1 |
| Dai, S; Guo, C; Li, W; Li, Y; Liu, F; Shi, Y; Song, X; Wang, B; Wang, J; Wang, L; Wang, Q; Wang, X; Zhang, L; Zhao, W; Zhu, F | 1 |
| Gao, H; He, Q; Qiu, Y; Shi, K; Wang, Y; Yin, S; Zhang, L; Zhang, Z | 1 |
| Hahm, KB; Han, YM; Jeong, M; Kim, MY; Lee, HJ; Ock, CY; Park, JM | 1 |
| Doi, S; Doi, T; Kawaoka, K; Masaki, T; Nakashima, A; Ueno, T; Yamada, K | 1 |
| Bennett, MV; Court-Vazquez, B; Gertner, M; Hwang, JY; Ofengeim, D; Pontarelli, F; Zukin, RS | 1 |
| Li, XX; Weng, LH; Wu, JY; Xu, Y; Yu, LJ; Zhang, Y | 1 |
| Bose, C; Karaduta, OK; Kaushal, GP; Shah, SV | 1 |
| Bartolotti, LJ; Bourdelais, AJ; Buchanan, MK; Chauvigne-Hines, LM; Frampton, AR; Goodwin, TJ; Kelly, CB; Mastro-Kishton, K; McIver, AL; Needham, CN; Neill, NE; Varadarajan, S; White, MC | 1 |
| Li, W; Lin, Y; Liu, R; Ma, J; Shao, N; Shi, Y; Wang, S; Wu, W | 1 |
| Fu, J; Hu, J; Liu, Z; Tang, M; Wang, L; Wen, J; Xue, L; Yang, R; Zhang, Y | 1 |
| Fan, L; Guo, D; Li, X; Lin, C; Liu, J; Qian, R; Shi, Z; Tang, X | 1 |
| Chang, HT; Chen, TH; Harroun, SG; Ku, CR; Zhang, Y | 1 |
| Feng, X; Guo, L; Hou, H; Zou, Y | 1 |
| Chagtoo, M; Chakravarti, B; George, N; Godbole, MM; Khan, S; Lakshmi, S; Singh, A; Tiwari, S | 1 |
| Chen, Y; Ge, W; Shen, Y; Wang, J; Xiao, Y; Yan, J; Zhang, C | 1 |
| Liu, C; Miao, Q; Wang, X; Wei, R; Wu, M; Xu, Y; Zhou, G; Zhu, S | 1 |
| Hu, L; Huang, L; Wang, H; Wang, J; Zhao, Y | 1 |
| Chen, R; He, B; Hu, W; Li, X | 1 |
| Guo, E; Jiang, X; Li, A; Li, R; Liu, A; Liu, S; Yang, J; Yang, Y | 1 |
| Cao, H; Dong Zhang, X; Li, J; Liu, X; Liu, Z; Wang, B; Yuan, H; Zhan, Z; Zhang, P | 1 |
| Gao, QL; Gong, C; Gong, W; Liu, Y; Ma, D; Wei, X; Yang, ZY; Ye, F; Zhang, TR; Zhou, XS | 1 |
| Choi, CM; Choi, YJ; Hwang, DW; Kim, SC; Kim, SW; Lee, JC; Lee, YJ; Park, KM; Rho, JK; So, KS | 1 |
| Chen, JT; Chen, RM; Cheng, BC; Chio, CC; Liu, SH; Yang, ST | 1 |
| Chen, L; Fan, T; Geng, Q; Hu, H; Huang, Z; Mao, Z; Wang, W; Xu, Y; Zhang, B | 1 |
| He, G; Luo, X; Luo, Z; Yang, J; Yang, X; Yi, J | 1 |
| Bai, Y; Cao, Z; Dong, S; Dou, C; Fei, J; Liu, C; Liu, X; Wang, Y | 1 |
| Cao, Y; Gan, G; Han, H; Li, X; Mi, J; Wang, B; Wang, X; Wang, Y; Wu, J; Xu, Y; Ye, M; Zhao, J; Zhu, D | 1 |
| Chen, N; Chen, YF; Lei, H; Li, ZH; Liu, H; Shi, Y; Wang, JJ; Yang, Y; Ye, QF | 1 |
| Chen, S; Chen, Y; Lai, B; Liang, H; Liu, J; Song, L; Tang, H; Xu, L; Yang, H; Yun, L; Zhou, K | 1 |
| Li, J; Mu, Y; Yan, WJ; Yang, J; Yin, TL; Zhang, Y | 1 |
| Ding, N; Gao, F; He, W; Lan, Y; Li, Z; Lu, H; Lv, X; Su, J; Zhao, K | 1 |
| Hikida, A; Hwang, GW; Ito, Y; Kuge, S; Miura, N; Naganuma, A; Ogiwara, Y; Zhang, ZT | 1 |
| Cheng, NT; Guo, A; Ma, LF; Meng, H; Wang, ZZ; Yu, HM; Zhang, L | 1 |
| Chen, P; Cheng, Z; Ding, F; Li, Y; Liu, J; Liu, L; Wang, Z; Yu, W; Zhang, X | 1 |
| Tan, YZ; Wang, GD; Wang, HJ; Zhou, P | 1 |
| Ji, C; Jia, H; Qian, H; Wang, B; Wang, J; Xu, W; Yan, Y; Yin, L; Yu, J; Zhang, B; Zhu, X | 1 |
| Jin, T; Kim, HS; Moon, WK; Zhang, M | 1 |
| Chen, A; Ling, Y; Luo, T; Song, X; Tang, H; Wang, X; Yang, P | 1 |
| Lee, CM; Morgan, ET; Tripathi, S | 1 |
| Gao, X; Liu, D; Liu, Y; Ma, X; Muhammad, W; Qian, X; Wang, J; Zhou, H | 1 |
| Cai, T; Dong, JJ; Liao, L; Shen, X; Zhang, XQ; Zhou, XJ | 1 |
| Gao, LP; Jing, YH; Lv, DD; Qi, CC; Song, YF; Wang, DG; Yin, J; Zhang, L | 1 |
| Abdoli, A; Bamdad, T; Feizi, A; Feizi, N; Fotouhi, F; Jamali, A; Jazaeri, EO; Mehrbod, P; Nargesabad, RN; Romani, B; Saleh, M; Soleimanjahi, H; Targhi, HS | 1 |
| Bissoyi, A; Kashyap, MP; Patra, PK; Rizvi, SI; Singh, AK | 1 |
| Li, H; Li, W; Yang, J; Zhang, H; Zheng, P; Zhou, Y | 1 |
| Cui, H; Hou, J; Huang, M; Jiang, X; Tang, C; Wang, F; Weng, X; Zhang, D; Zhao, E; Zhong, X | 1 |
| BasuRay, S; Cohen, JC; Hobbs, HH; Smagris, E | 1 |
| He, K; Liu, C; Liu, Z; Ma, Q; Ndege, I; Wang, X; Yu, Q; Yu, Z | 1 |
| Chen, L; Feng, F; He, L; Huang, S; Li, L; Liu, M; Wu, D; Xiao, L; Xie, F; Zhou, Q | 1 |
| Jeong, K; Jeong, MS; Kim, SH; Kwon, HY; Sohn, EJ | 1 |
| Bao, L; Feng, X; Han, X; Jin, MF; Li, G; Li, M; Li, RH; Sun, B; Xu, LX; Yang, YY | 1 |
| Kim, EH; Lee, J; Roh, JL; Shin, D | 1 |
| Chen, Z; Jin, J; Li, H; Liu, X; Ma, X; Yao, X; Zhang, P | 1 |
| Bi, B; Cheng, Y; Wang, H; Xu, J; You, T; Zeng, B; Zheng, W; Zhong, J | 1 |
| Fribourg, M; Heeger, PS; Leventhal, JS; Ni, J; Nina Papavasiliou, F; Yue, Z | 1 |
| Gu, T; Jiang, X; Liu, H; Liu, K; Shi, E; Yan, L; Yu, Y | 1 |
| Qiu, W; Sun, Y; Wang, P; Zhang, D; Zhang, F; Zhang, P | 1 |
| Huang, S; Huang, W; Huang, Z; Jia, Z; Lin, L; Zhu, Z | 1 |
| Guan, H; Han, X; Jin, F; Li, X; Qin, J; Shan, M; Wang, Y; Zhang, H; Zhang, J | 1 |
| Bechor, S; Elia, N; Gericke, M; Haim, Y; Las, G; Leikin-Frenkel, A; Nachmias, D; Rudich, A; Tarnovscki, T; Vatarescu, M | 1 |
| Chen, L; Deng, B; Kang, C; Liu, J; Pan, X; Shao, L; Song, B; Wei, L | 1 |
| Bai, Y; Jiang, L; Liu, N; Liu, X; Sun, X; Wang, S; Wu, X; Yang, G; Yao, X; Zhai, X | 1 |
| Cao, X; Kuang, L; Lu, Z | 1 |
| Li, YC; Ma, CL; Qian, RK; Qiao, S; Song, SD; Sun, RJ; Wang, XF; Zhang, X | 1 |
| Casini, G; Clemente, N; De Cillà, S; Farruggio, S; Filippini, D; Gatti, V; Grossini, E; Mary, D; Raina, G; Rossetti, L; Vezzola, D; Vujosevic, S | 1 |
| Ding, L; Hu, T; Jiang, W; Jin, Z; Qiu, C; Sun, Z; Wang, Y; Yang, J; Yang, M; Zhang, N; Zhang, S; Zhang, Z | 1 |
| Lee, DI; Lee, JE; Lee, JS; Lee, SM; Park, SH; Yu, HS | 1 |
| Benavides, GA; Cofield, SS; Darley-Usmar, V; Dodson, M; Johnson, MS; Mitra, K; Ouyang, X; Redmann, M; Wani, WY; Zhang, J | 1 |
| Guo, D; Han, X; Li, T; Li, Z; Ma, J; Shui, S; Yan, L | 1 |
| Chen, HP; Chen, ZH; Li, ZY; Shen, HH; Wang, Y; Wu, YF; Xu, XC; Zhao, Y; Zhou, JS | 1 |
| Facskó, A; Josifovska, N; Liskova, P; Moe, MC; Nagymihály, R; Noer, A; Petrovski, G; Szabó, DJ; Veréb, Z | 1 |
| He, F; Huang, G; Li, B; Li, X; Lian, J; Lyu, X; Ni, Z; Wu, Y; Xiong, H; Yan, X; Zeng, Y; Zhang, N; Zhang, Y | 1 |
| Li, Y; Liu, M; Su, P; Sun, L; Wu, Z; Yang, X; Zhang, J; Zhao, M | 1 |
| Chen, S; Dai, L; Gao, W; Jin, Z; Lin, D; Wang, J; Wang, L; Wu, L | 1 |
| Chen, HY; Hsia, SM; Huang, TC; Lin, LC; Shieh, TM; Wu, CH | 1 |
| Cheng, W; Duan, SB; Lei, R; Liu, N; Luo, M; Tang, MM; Xu, Q | 1 |
| Cui, W; Ding, W; Fan, W; Gu, Y; Hu, J; Wang, Z | 1 |
| Cheng, HL; Chu, LY; Hsueh, YC; Wu, KK | 1 |
| Chai, R; Ding, X; Fang, Q; Gao, X; Guo, L; He, Z; Kong, W; Li, H; Liu, D; Liu, Y; Lu, L; Sha, S; Shu, Y; Tang, M; Zhang, X; Zhou, H | 1 |
| Fan, B; Ma, Y; Zhang, A; Zhang, X | 1 |
| Cui, Q; Li, Y; Wang, J; Wang, Y; Yang, C; Yue, J | 1 |
| Deng, JB; Deng, JX; Fu, S; Li, YQ; Liu, B; Shi, ZY; Wang, L; Wang, Q | 1 |
| Hu, LK; Sun, YL; Wang, HJ; Zhao, T; Zhao, WW | 1 |
| David, SS; Eichman, BF; Lay, KT; Mullins, EA; Rokas, A; Shen, XX; Shi, R; Yuen, PK | 1 |
| Hou, Q; Jia, MM; Jiang, Y; Lu, YQ; Qiu, T; Wang, BH; Wang, XH; Zhang, ZX | 1 |
| Fazal, F; Grose, V; Leonard, A; Rahman, A; Slavin, SA | 1 |
| Aschner, M; Chen, R; Gao, N; Gu, A; Kay, SA; Li, X; Lu, R; Meng, Q; Sun, H; Tang, B; Wang, S; Wu, J; Wu, S; Yang, H; Zhang, C | 1 |
| Fang, L; Li, S; Liu, R; Wang, J | 1 |
| Jiang, L; Rong, D; Wang, X; Wu, TT; Zhu, YQ | 1 |
| Bai, F; Huang, Q; Lin, X; Lu, C; Lu, S; Lu, Z; Nie, J; Wang, Y; Zhu, X; Zhuo, L | 1 |
| Choi, HS; Park, HJ; Son, HJ; Sul, OJ | 1 |
| Ding, DF; Dong, CL; Lu, YB; Ma, JH; Pan, ML; Xu, XH; Ye, XL; Yong, HJ; You, N; You, Q | 1 |
| Cao, T; Chen, C; Fang, W; Gu, Y; Li, X; Shan, Y; Shi, X; Xin, Y; Zhou, Y | 1 |
| Gao, M; Hou, X; Liu, H; Liu, Y; Peng, F; Shu, M; Wang, K; Wang, X; Xue, L; Ye, J; Zhao, B; Zhao, S; Zhao, W; Zhong, C | 1 |
| Deng, Y; Liu, C; Liu, W; Ma, Z; Tan, X; Wang, C; Xu, B; Xu, ZF; Yan, DY; Yang, TY | 1 |
| Fang, JM; Guo, XL; Hu, F; Wang, H; Wei, LΧ; Xu, Q; Zhu, ZΖ | 1 |
| Dash, PK; Hood, KN; Hylin, MJ; MacGowan, JS; Moore, AN; Rozas, NS; Tangavelou, K; Zhao, J | 1 |
| Han, D; Jia, YP; Li, Q; Mao, XH; Tang, B; Tong, YN; Xiang, Y; Xue, J; Zhang, ZJ; Zhu, P | 1 |
| Gao, L; Li, AL; Lv, JB | 1 |
| Jia, H; Liang, Z; Qian, H; Tandra, N; Wang, J; Xu, W; Yan, Y; Zhang, B | 1 |
| Boido, M; De Amicis, E; Garcera, A; Guglielmotto, M; Piras, A; Puyal, J; Schiaffino, L; Soler, RM; Tamagno, E; Valsecchi, V; Vercelli, A | 1 |
| Chang, HC; Hsu, HY; Huang, AM; Lin, KW; Lin, WH; Ni, C; Shih, C; Su, CL; Wang, DL; Wu, LH | 1 |
| Duan, N; Li, M; Liu, HL; Ma, JB; Yao, SX; Zhi, LQ | 1 |
| Dai, P; Li, C; Li, Y; Li, Z; Zhou, X | 1 |
| Atsuzawa, Y; Fujisaki, H; Hattori, S; Hayashi, T; Ikejima, T; Liu, W; Liu, WW; Liu, XL; Lu, ZY; Onodera, S; Tashiro, SI; Wu, QJ; Yamato, M; Yao, GD; Zhang, X; Zhao, YL | 1 |
| Han, D; Huang, H; Huang, L; Li, X; Li, Z; Shang, M; Yu, C; Yu, X; Zhu, H; Zhu, S | 1 |
| Jiang, YG; Li, H; Lou, JS; Mi, WD; Shi, XY; Sun, L; Tan, J; Xu, LH; Zhang, X | 1 |
| Li, X; Lu, Q; Wang, G; Wang, Y; Xie, W | 1 |
| Ding, S; Li, H; Wang, Y; Zhu, Y | 1 |
| Liang, Q; Liu, Y; Zhang, S | 1 |
| Chen, SH; Huang, KJ; Kuo, CH; Lee, YR; Lin, CY | 1 |
| Li, Y; Lin, S; Mei, X; Xu, C; Zhang, P | 1 |
| Jiayan, C; Kongdan, L; Yan, C; Yuanjie, T; Zhengqun, X | 1 |
| Cao, L; Cheng, K; Su, Q; Zhang, X; Zhang, Y | 1 |
| Li, W; Liao, L; Liu, Y; Su, Q; Zhao, J; Zhuang, X | 1 |
| Han, SH; Kim, JE; Kim, JS; Takanche, JS; Yi, HK | 1 |
| Bu, J; Hou, B; Li, G; Liang, Z; Xiao, X; Yang, L; Zhu, Y | 1 |
| Feng, YB; Guo, TY; Li, DY; Liu, GW; Ma, C; Wang, T; Wangyang, Y; Zheng, X | 1 |
| Gong, J; He, Q; Jin, J; Shen, W; Ye, M; Zhang, H; Zhao, L; Zou, W | 1 |
| Arisan, ED; Gurkan, AC; Ilhan, H; Unsal, NP; Yerlikaya, PO | 1 |
| Chu, BX; Fan, RF; Lin, SQ; Wang, L; Wang, ZY; Yang, DB | 1 |
| Fuentes, F; Galletti, JG; Geffner, JR; Gerber, PP; Guzman, M; Iula, L; Jancic, CC; Keitelman, IA; Ostrowski, M; Sabbione, F; Trevani, AS | 1 |
| Hua, W; Kang, L; Li, S; Li, W; Liu, W; Luo, R; Song, Y; Tu, J; Wang, K; Wu, X; Yang, C; Yang, S; Yang, W; Zhang, Y | 1 |
| Khanna, VK; Kumar, D; Pandey, A; Pant, AB; Rajpurohit, CS; Singh, S; Srivastava, A; Srivastava, P | 1 |
| Li, X; Li, Z; Liu, W; Liu, Z; Song, Y | 1 |
| Guo, Y; Lu, J; Qian, P; Tao, H; Wang, F; Zhu, H | 1 |
| Ding, X; Gao, Y; Li, Q; Xie, J | 1 |
| Fang, SH; Fu, YJ; Gao, C; Li, J; Wang, P; Wang, W; Yao, LP; Zhang, J; Zhang, SD | 1 |
| Chen, J; Lu, N; Ouyang, Y; Wan, J; Wu, D; Xia, L; Yang, X; Zhu, Y | 1 |
| Li, W; Meng, QG; Qu, ZW; Sun, XX; Xie, G; Xu, MX; Yang, Q | 1 |
| Hsu, TI; Jou, IM; Ko, PY; Kuo, YL; Su, FC; Tu, YK; Yang, CC | 1 |
| Li, Q; Qin, J; Sheng, X; Zhu, P | 1 |
| Chen, C; Li, X; Wang, L | 1 |
| Fang, M; Fei, X; Gong, F; Hua, S; Li, L; Li, Q; Qi, C; Zhang, Y | 1 |
| Li, M; Liu, X; Nie, D; Peng, Y; Ye, L; Zhu, M | 1 |
| Cheng, W; Duan, SB; Lei, R; Li, XW; Luo, M; Tang, CY; Yang, SK; Zhao, F | 1 |
| Hou, HT; Liu, B; Long, HL; Wang, HL; Yang, WS; Yu, JK; Zhang, FF | 1 |
| Duan, Z; Gao, P; Garbutt, C; Hornicek, FJ; Kan, Q; Ma, H; Shi, H; Wang, J | 1 |
| Arroyo, DS; Avalos, MP; Bussi, C; Cancela, LM; Gaviglio, EA; Iribarren, P; Peralta Ramos, JM | 1 |
| Niu, G; Wang, J; Wang, X; Zhang, X; Zhao, Y; Zhu, D | 1 |
| Chen, CL; Chen, JT; Chen, YH; Liang, CM; Lu, DW; Tai, MC | 1 |
| Chiu, JF; Deng, Y; Fan, Y; Li, G; Liu, J; Xu, C; Zhang, J | 1 |
| Green, JE; Hunter, KW; Nini, R; Vera-Ramirez, L; Vodnala, SK | 1 |
| Ando, T; Ito, T; Ochiai, T; Suzuki-Karasaki, M; Suzuki-Karasaki, Y; Tokuhashi, Y; Tokunaga, T; Yoshida, Y | 1 |
| Bi, C; Cai, B; Ding, F; Du, Z; Han, Z; Hua, B; Huang, Q; Jin, M; Liu, T; Ma, W; Wang, X; Yu, Y; Yuan, Y; Zhang, L | 1 |
| Duan, XT; Shao, N; Xu, XS; Zhang, X; Zhang, YF | 1 |
| Chen, X; Gunzer, M; Kemper, T; Lin, Y; Lu, M; Squire, A; Wang, X; Wu, C; Zhang, J | 1 |
| Liang, Q; Liu, Y; Wang, N; Zhang, S | 1 |
| Chen, K; Chen, L; Li, G | 1 |
| Baek, E; Lee, GM; Lee, JS | 1 |
| Ayoub, B; Blaquière, M; Bughin, F; Catteau, M; Gouzi, F; Hayot, M; Maury, J; Mercier, J; Passerieux, E; Pomiès, P | 1 |
| Cai, JH; Geng, N; Li, SL; Li, YC; Shi, BJ; Xua, WL; Zhong, ZY; Zhou, H | 1 |
| Eberli, D; Gross, O; Kranzbühler, B; Mortezavi, A; Salemi, S; Simon, HU; Sulser, T | 1 |
| Chen, CD; Dai, LN; Lai, XH; Wang, J; Wang, M | 1 |
| Dai, HF; Huang, FY; Lin, YY; Wang, H; Zhao, HG; Zhou, SL | 1 |
| Ajami, M; Anjam-Najmedini, A; Atashi, A; Houshmand, M; Kazemi, A; Ojaghi, M; Sadri, M; Tavakoli, R; Yazdi, N; Zarif, MN | 1 |
| Jin, Y; Li, X; Xia, G; Xiao, J; Zhou, J; Zhu, T | 1 |
| An, W; Cao, S; Lai, H; Li, X; Lin, X; Liu, M; Zhang, D; Zhao, G | 1 |
| Chen, X; Dai, S; Li, D; Ma, S; Tan, Q; Tang, Z; Wu, S; Yu, Y; Zang, G | 1 |
| Chen, BH; Chen, JY; Chiu, CC; Chiu, YH; Hsu, HW; Hsu, SH; Huang, KC; Huang, WP; Liu, W; Wu, CY | 1 |
| Sui, S; Yin, X; Zhang, B | 1 |
| Campos, CBL; Góes, CG; Morais, FV; Onorio, DS; Ribeiro, GF | 1 |
| Chi, RF; Fan, B; Li, B; Qin, FZ; Sun, Y; Wang, JP; Wang, K; Yang, ZJ | 1 |
| Huang, X; Jiang, J; Liu, H; Lu, Y; Tan, S; Wu, B; Xu, M | 1 |
| Chen, H; Guo, C; Jia, Z; Li, Y; Xia, W; Yin, J; Zhang, A; Zhang, S; Zhang, Y | 1 |
| Bravo-Sagua, R; Breitwieser, G; Cifuentes, M; Fuentes, C; Lavandero, S; Mattar, P; Tobar, N; Troncoso, R | 1 |
| Chen, S; Gao, W; Jin, Z; Wang, J; Wang, L; Wu, H | 1 |
| Chen, D; Chen, Z; Dai, C; Han, Z; He, F; Li, Y; Tan, R; Tian, H; Wang, G; Wang, M; Wei, L; Yang, B; Yang, H; Zhang, B | 1 |
| Chen, J; Min, S; Wang, X; Xie, F; Yang, J | 1 |
| Bao, J; Liu, N; Shi, Y; Tao, M; Yuan, W; Zhuang, S | 1 |
| Dang, R; Guo, Y; Jiang, P; Li, G; Liu, Y; Qiao, Y; Xie, R; Xu, P; Zhou, X | 1 |
| Chen, H; Deng, J; Wen, T; Yang, C; Yang, M; Zhang, Z | 1 |
| Chen, FP; Feng, G; Fu, YF; Liu, X; Mu, GF; Wang, X; Xiong, D | 1 |
| Dong, Y; Guan, H; Liu, J; Wang, L; Xia, X; Xu, L; Xu, M; Yu, H | 1 |
| Gao, D; Li, S; Sun, H; Tang, T; Tang, Y; Zhu, J | 1 |
| He, WK; Li, L; Liang, JB; Lu, YX; Sun, YH; Wang, XT; Wu, XD; Zhu, HH | 1 |
| Luan, B; Sun, C | 1 |
| Huang, X; Jiang, B; Li, Y; Liang, P; Liu, Z; Xiao, X; Zhang, M; Zhang, P | 1 |
| Hseu, YC; Kao, MC; Karuppaiya, P; Li, ML; Mathew, DC; Shen, YC; Yang, HL | 1 |
| Dai, Y; Ding, J; He, Y; Hu, S; Ye, C; Yin, W; Yu, F; Yu, Y | 1 |
| Liu, T; Yang, JW; Zhang, QH | 1 |
| Guo, H; Li, X; Lu, B; Tian, Q; Wang, Y; Wu, M; Xiong, X; Zhang, H; Zhang, Q; Zhou, T | 1 |
| Cai, X; Chen, K; Chen, X; Hu, J; Hu, Y; Huang, A; Li, X; Liang, L; Tang, N; Wang, K; Zhang, W | 1 |
| Chen, D; Chen, Y; Duan, Z; Ji, J; Ren, F; Shi, H; Xu, P; Yue, X; Zhang, Y | 1 |
| Li, J; Li, JY; Li, YF; Lu, YT; Nan, FJ; Xiao, YF | 1 |
| Cheng, Y; Huang, N; Huang, Q; Tan, Y; Tang, M; Zhang, P; Zhang, X; Zhao, G | 1 |
| Deng, S; Du, J; Jing, X; Li, Y; Liu, B; Liu, Y; She, Q | 1 |
| Chen, X; Gan, F; Huang, K; Liu, D; Pan, C; Qian, G; Sun, Y; Xu, J; Xu, S | 1 |
| Cheng, E; Cheng, Y; Olden, BR; Pun, SH | 1 |
| Fathi, F; Garjani, A; Malekinejad, H; Montaseri, A; Rahbarghazi, R; Rezabakhsh, A | 1 |
| Bai, HL; Dai, XY; Guo, FX; Hu, YW; Kang, CM; Li, P; Lu, JB; Lu, ZF; Wang, Q; Wu, Q; Xiao, L; Xu, BM; Xu, YJ; Ye, S; Zheng, L | 1 |
| Kovacevic, Z; Park, KC; Richardson, DR; Sahni, S | 1 |
| Bobrowska-Korczak, B; Gątarek, P; Giebułtowicz, J; Kałużna-Czaplińska, J; Rosiak, A | 1 |
| Dong, Y; Wu, Y; Xing, CG; Yang, XD; Ye, ZY; Zhao, GL | 1 |
| Chen, B; Chen, Z; Fu, C; He, L; Liu, X; Lu, Y; Xu, Z; Zeng, Z; Zhang, X | 1 |
| Chiu, CH; Huang, YS; Kao, LT; Li, IH; Lin, YY; Ma, KH; Shih, JH; Shiue, CY; Yeh, TY | 1 |
| Chen, Z; Li, X; Lin, Z; Ma, X; Wu, X; Zou, L | 1 |
| Diao, C; Du, Y; Liu, H; Liu, X; Wang, L | 1 |
| Chen, SB; Ling, X; Liu, S; Liu, WC; Tang, J; Xu, QR; Yu, BT | 1 |
| Cai, Z; Yang, B; Yang, M; Yin, D; Zhang, W; Zhao, W | 1 |
| Cao, L; Cheng, K; Yuan, S; Zhang, X | 1 |
| Buland, JR; Chou, WYY; Cole, FS; Dawson, Z; Homayouni, A; Huang, H; Jia, H; Kim, H; Luke, CJ; Moreno, M; Pak, SC; Silverman, GA; Thomas, BJ; Wambach, JA; Wight, IE | 1 |
| Haddock, AN; Ji, B; Li, X; Lu, N; Ren, Y; Wan, J; Xia, L; Yang, X; Zhu, Y | 1 |
| Chen, L; Chen, Y; Chi, H; Jiao, G; Kong, M; Ma, W; Qiao, Y; Wang, H; Wu, W; Zhou, H | 1 |
| Abuzeid, AMI; Hu, J; Li, G; Li, J; Liao, S; Lin, X; Lv, M; Qi, N; Sun, M; Wu, C; Xiao, W; Yu, L | 1 |
| Liang, TS; Ma, SL; Yang, CL; Yang, DK; Yang, Y; Zhao, ZJ; Zuo, XX | 1 |
| An, J; Jiang, P; Li, Y; Shen, Y; Wang, M; Zhang, J; Zhou, N | 1 |
| Chen, Z; Ding, Y; Han, F; Han, R; Li, M; Qin, YY; Qin, ZH; Sheng, R; Wang, MM; Wang, XX; Wang, Y; Wu, J; Zhang, DM; Zhang, T | 1 |
| Chen, X; Du, T; Ji, M; Jin, J; Lai, F; Liu, D; Xue, N; Yan, C; Yu, X; Zhang, S | 1 |
| Chen, G; Dong, J; Gong, Z; Guo, L; Jiang, M; Li, G; Lin, L; Liu, S; Pan, R; Tang, H; Wang, J; Xing, Y; Yan, L | 1 |
| Cai, H; Liang, X; Lin, S; Pan, Y; Zhao, Y; Zhou, P | 1 |
| Byun, J; Jeong, MS; Jeoung, D; Jung, HS; Kim, HU; Kim, M; Kim, Y; Kwon, Y; Mun, JY; Park, Y | 1 |
| Jin, G; Li, Q; Wang, L; Yang, H; Yu, H | 1 |
| Cong, L; Gao, Z; Han, X; Jiang, Y; Kou, J; Liu, Z; Yang, L; Zheng, Y | 1 |
| Chen, W; Fan, J; Ju, D; Li, Y; Liu, P; Luan, J; Song, P; Wang, S; Wang, Y; Wang, Z; Zhang, X | 1 |
| Cao, MM; Jiang, W; Li, YB; Liu, GD; Su, Y; Wang, J; Zhu, LB | 1 |
| Chen, L; Ding, P; Song, L; Tan, J; Tang, Q; Wang, Z; Wei, Y; Xia, M | 1 |
| Cui, Y; Gao, T; Hou, C; Liu, H; Wang, A; Wang, Y; Yu, J; Zeng, Q; Zhang, B; Zhang, Z; Zhao, L | 1 |
| Guan, X; Li, J; Liang, X; Lin, J; Song, W; Sun, Y; Wang, C | 1 |
| Dong, A; Duan, Q; Tao, K; Yang, W; Zhu, X | 1 |
| He, Q; He, X; Wang, DH | 1 |
| Jiang, X; Shi, M; Sun, D; Wang, L; Yang, S; Zhang, C; Zhu, X | 1 |
| Antunes, GL; Breda, RV; da Costa, MS; da Cunha, AA; Ferreira, FS; Gassen, RB; Kaiber, DB; Marques, EP; Pitrez, PM; Schmitz, F; Silveira, JS; Stein, RT; Wyse, ATS | 1 |
| Fan, X; Fang, Z; Huang, H; Li, S; Wang, S; Wang, Y; Yang, Y; Ye, Q; Zeng, X | 1 |
| Cheng, C; Huang, L; Jin, X; Mei, L; Sun, S; Sun, X; Zhang, J | 1 |
| Li, B; Li, Y; Lin, L; Luo, Y; Niu, L; Yao, X | 1 |
| Feng, Y; Liu, H; Rui, L; Wu, X | 1 |
| Bagamanshina, AV; Kähne, T; Kit, YY; Koval, OA; Kuligina, EV; Lavrik, IN; Nushtaeva, AA; Richter, M; Richter, VA; Starykovych, MO; Troitskaya, OS; Wohlfromm, F; Yunusova, AY | 1 |
| Cheng, M; Liang, X; Liu, H; Sai, N; Wang, M; Wang, X; Yang, L; Zhang, X | 1 |
| Hisatsune, A; Katsuki, H; Kurauchi, Y; Oshima, M; Seki, T | 1 |
| Chu, Y; Cui, K; Huang, T; Jing, J; Lin, J; Song, X; Wang, X; Yue, B; Zhang, X | 1 |
| Bi, J; Han, D; Liang, J; Lu, Y; Ren, L; Wang, P | 1 |
| Ji, Z; Yang, S; Zhang, J; Zhang, L | 1 |
| Fan, H; Guo, X; Kong, Y; Liu, L; Zhang, H; Zhang, Q; Zhou, Y | 1 |
| Alizadeh, S; Meshkani, R; Sadeghi, A; Shabani, M | 1 |
| Chen, CC; Chen, YJ; Huang, HL; Leu, YS | 1 |
| Li, Q; Liu, C; Peng, S | 1 |
| Chen, F; Chen, Y; Dai, B; Hu, W; Qian, X; Song, S; Wang, K; Wu, X; Zhou, R; Zhu, C; Zhu, F | 1 |
| Buzzacott, P; He, C; Huang, G; Nie, S; Wang, M; Xu, W; Yi, H; Zhang, K | 1 |
| Dou, ZC; Gao, L; Li, SM; Liang, X; Ren, WH; Zhi, KQ | 1 |
| Ha, DS; Ha, TS; Min, SY; Seong, SB | 1 |
| Alard, J; Boutillier, D; Dabboussi, F; Desramaut, J; Grangette, C; Kassaa, IA; Nguyen, HTT; Peucelle, V; Pot, B; Rosenstiel, P; Zaylaa, M | 1 |
| Bystrzycka, W; Cieloch, A; Ciepiela, O; Demkow, U; Glodkowska-Mrowka, E; Heropolitanska-Pliszka, E; Jankowska-Steifer, E; Manda-Handzlik, A; Muchowicz, A; Skrobot, A; Wachowska, M | 1 |
| Chen, Y; Luo, C; Zhou, Q; Zhu, C | 1 |
| Funahashi, H; Kohata-Ono, C; Wakai, T | 1 |
| Chen, B; He, S; Li, L; Luo, B; Yan, F; Zhou, Q | 1 |
| Balduini, W; Carloni, S | 1 |
| Chu, XS; Cui, DZ; Fan, QQ; Huang, C; Huang, CY; Li, YB; Sui, XX | 1 |
| Duan, B; Liao, Y; Xia, B; Zhang, X; Zhang, Y | 1 |
| Cai, K; Dai, L; He, Y; Li, K; Liu, J; Lu, L; Luo, Z; Mao, Y; Xia, Z; Xue, C; Zhou, J | 1 |
| Cao, H; Chen, C; Jia, Q; Shen, D; Xing, S; Yan, L | 1 |
| Chung, LY; Huang, HJ; Sun, GH; Sun, KH; Tang, SJ; Wu, YC; Yang, KC | 1 |
| Wang, X; Wu, Y | 1 |
| Wang, XH; Zhan, LS; Zhang, TG; Zhang, YL; Zhou, QQ | 1 |
| Du, W; Gong, R; He, M; He, X; Lei, H; Li, G; Li, X; Pang, P; Wang, Y; Yan, G; Yu, S; Yuan, Y | 1 |
| Bi, P; Gao, Q; Guan, Y; Li, X; Luo, D; Mi, Q; Xiang, H; Yang, B; Yang, G; Zeng, W | 1 |
| Shao, Y; Sun, Y; Wu, M; Xu, A; Yang, Y | 1 |
| Baumgarner, BL; Brown, SL; Crocker, CL; Cutrone, M; Dintino, MM; Enyart, DS; Kinsey, ST; Stansell, JR | 1 |
| Chen, N; Fan, Y; Hu, SF; Huang, WK; Li, YM; Rao, M; Su, P; Wang, M; Wang, XF; Zhang, YZ | 1 |
| Chen, J; Chen, X; Li, A; Li, X; Li, Z; Wang, Z; Zeng, C | 1 |
| Choi, H; Jung, JY; Kim, HJ; Son, ED | 1 |
| Carroll-Portillo, A; Coffman, C; Lin, HC; Ritz, NL; Singh, SB | 1 |
| Hou, JM; Li, N; Wu, HJ; Xue, Y; Zhang, Y; Zhang, ZN; Zhao, LJ | 1 |
| Khorsandi, L; Saki, G; Valizadeh, A; Yahyavy, S | 1 |
| Asai, H; Doenst, T; Matsui, Y; Shingu, Y; Sugimoto, S; Wakasa, S; Yamakawa, T | 1 |
| Feng, Z; Kang, Y; Li, Y; Wen, H; Zheng, J; Zhu, J | 1 |
| Ohta, T; Okubo, S; Shoyama, Y; Uto, T | 1 |
| Brothers, KM; Shanks, RMQ; Stella, NA | 1 |
| Dongmin, G; Huijun, H; Jun, L; Liu, M; Qiufen, T; Wensheng, L; Xiaolong, L; XueMei, H; Yuping, P; Zhaolin, Z; Zuo, W | 1 |
| He, HN; Ji, T; Liu, X; Miao, YL; Yin, SY; Zhang, X; Zhou, J | 1 |
| Kady Keita, N; Liu, H; Tan, Z; Wang, L; Zhang, Y | 1 |
| Bao, H; Chen, F; Violetta, L; Xie, H; Zheng, S | 1 |
| Aryal, B; Cuervo, AM; Diaz, A; Fernández-Hernando, C; Liu, X; Madrigal-Matute, J; Ramírez, CM; Sessa, WC; Suárez, Y; Torrecilla-Parra, M; Zhang, X | 1 |
| Wu, X; Zeng, X; Zhou, W | 1 |
| Chen, KH; Chen, NJ; Chen, ST; Chou, YJ; Dzhagalov, I; Fu, SL; Lin, CC; Lin, CH | 1 |
| Eberli, D; Kranzbühler, B; Mortezavi, A; Salemi, S; Sulser, T | 1 |
| Chen, F; Deng, J; Hu, T; Kong, D; Liu, Y; Ning, H; Shan, L; Zhang, Z | 1 |
| Cui, Y; Gong, L; Jing, T; Li, X; Lu, H; Ma, D; Tang, Y; Wu, S; Xiao, X; Xu, H; Zhang, J; Zhao, H; Zhou, Q | 1 |
| Horie, T; Ikeda, T; Kida, T; Mimura, M; Oku, H; Taki, K | 1 |
| Ahmadi, Z; Ashrafizadeh, M; Mohammadinejad, R; Sahebkar, A; Tavakol, S | 1 |
| Cao, Y; Cui, Y; Jiao, Y; Liu, H; Meng, Z; Pan, L; Ren, Y; Wang, R; Wu, H; Yang, X | 1 |
| Huang, D; Shi, Y; Si, Q; Zhang, N | 1 |
| Cao, K; Liu, J; Liu, Z; Shan, W; Wang, R; Wen, Q; Zhang, B | 1 |
| Chung, T; Jung, H; Lee, HN | 1 |
| Gao, GD; Li, HB; Li, L; Liu, JD; Song, YW; Zhang, K | 1 |
| Chen, L; Coffie, JW; Fang, L; Fang, Z; Gao, X; Li, C; Ma, L; Song, M; Wang, H; Wang, Q; Wang, S; Yang, W; Zhang, L | 1 |
| Bunik, V; Che, L; Fan, B; Li, GY; Pan, YR; Song, JY; Wang, Y; Zhang, SM | 1 |
| Chen, K; Deng, Y; Liao, J; Liu, B; Liu, H; Liu, J; Pu, Y; Xiang, J; Zhang, J; Zhang, X | 1 |
| Balmori-Cedeno, J; Liu, JT; Lumsden, JS; Misk, E | 1 |
| Guo, L; Li, S; Qian, G; Wu, X; Zhang, X; Zhao, S | 1 |
| Kaushik, I; Ranjan, A; Srivastava, SK | 1 |
| Jiao, P; Li, L; Ma, J; Ma, Y; Teng, W; Tian, Y; Wang, W; Yan, W; Zhao, T | 1 |
| Liu, S; Liu, X; Lu, Y; Wu, Y; Xie, Y; Yang, R; Zhou, D; Zhou, Y | 1 |
| Chen, G; Chen, S; Li, H; Sun, Z; Tan, S; Yang, S; Yao, S; Zhu, L | 1 |
| Abdoli, A; Bashar, R; Gharibzadeh, S; Heydarabadi, FH; Sayyah, M; Sheikholeslami, F | 1 |
| Bao, G; Chen, H; Ding, J; Gao, W; Li, J; Li, Z; Lou, J; Lou, Z; Wang, X; Wu, C; Xiao, J; Xu, H; Zhou, K | 1 |
| Kim, HA; Kim, HJ; Kook, JH; Lee, YH; You, M | 1 |
| An, P; Fan, D; Guo, Z; Liu, FY; Ma, SQ; Tang, N; Tang, QZ; Wu, HM; Yang, Z | 1 |
| Chen, L; Chen, YC; Tu, Y; Wang, Y; Xia, C | 1 |
| Jiang, L; Sun, Q | 1 |
| Chen, J; Jiang, R; Li, Y; Liu, F; Lou, Y; Peng, F; Peng, W; Qian, K; Shao, Q; Zeng, Z; Zhan, Y; Zhao, N | 1 |
| Chen, SB; Dai, SH; Lin, HQ; Lin, X; Ling, H; Liu, S; Liu, WC; Tang, J; Yu, BT | 1 |
| Averill-Bates, DA; Grondin, M; Kassis, S | 1 |
| Guo, Q; Manthari, RK; Sun, Z; Wang, J; Yang, K; Yuan, M; Zhao, Y | 1 |
| Han, Z; Jing, B; Li, J; Lin, Y; Sun, Z; Yan, H; Yan, Y | 1 |
| Feng, G; Guo, R; Liu, J; Su, Z; Zhai, Y; Zhang, H; Zhao, F; Zhu, J | 1 |
| Bi, Y; Fang, F; Huang, Y; Liu, X; Lu, YY; Shu, S; Xi, T; Zhang, L; Zhang, X; Zhang, Z | 1 |
| Du, L; Jin, X; Qi, Z; Song, G; Yang, F; Yang, X; Zong, X | 1 |
| Chen, Y; Dai, Y; Gao, Y; He, X; Li, TH; Yan, SB | 1 |
| Feng, L; Li, X; Liu, Q; Qiao, J; Shi, S; Wang, B; Wang, S; Wang, Y; Zhang, D; Zhong, C | 1 |
| Cheng, Y; Li, X; Ma, A; Pan, X; Wang, J; Yang, S; Yin, R; Zhu, X | 1 |
| Cao, L; Dong, L; Huang, S; Liu, T; Liu, X; Liu, Y; Pan, Y; Wang, J; Wu, J; Xu, J; Zhao, J; Zou, M | 1 |
| Deng, Y; Du, X; Du, Y; Liu, P; Liu, X; Yang, C; Yang, H | 1 |
| Cai, Z; Chang, S; Jiang, S; Liu, F; Ni, G; Song, Y; Zhang, A; Zhang, X; Zhang, Z | 1 |
| Li, G; Rao, H; Xu, W | 1 |
| Beksac, M; Dou, R; Gu, C; Guo, M; Janz, S; Jurczyszyn, A; Qian, J; Wei, R; Wu, W; Yang, S; Yang, Y; Yuan, Y; Zhang, Y | 1 |
| Jin, Y; Li, J; Liu, Z; Shi, Q; Sun, W; Yu, L | 1 |
| Chen, JW; Jiang, Y; Liu, D; Murao, K; Sun, WP; Wang, LH; Xue, R; Zhang, GX | 1 |
| Bartholomew, S; Bommareddy, A; Reed, M; Walters, C | 1 |
| Hou, J; Wang, Y; Wu, H; Xue, Y; Zhang, Y | 1 |
| Cheng, L; Ma, L; Wang, M; Zeng, L; Zhang, M; Zhang, YZ; Zhu, CQ | 1 |
| Cai, R; Che, X; Fu, X; Liu, Y; Luo, J; Yang, J; Yang, Y; Yao, Y; Yu, X; Zhang, H; Zhou, MS | 1 |
| Cao, Q; Liu, Z; Luo, J; Xiong, Y; Ye, Q | 1 |
| Cheng, T; Lai, W; Lu, Y; Ma, R; Peng, Y; Shi, B; Shi, J; Wang, Y; Wu, X; Yang, G; Yi, H; Yu, D | 1 |
| Bao, B; Chen, W; Guo, J; Pan, J; Zhang, D; Zhang, M | 1 |
| Cao, J; Jiao, X; Jin, W; Lei, Z; Li, D; Wang, J; Zhang, Y; Zhang, Z | 1 |
| Deng, Y; Hao, Y; Liao, W; Liu, H; Mao, L; Sun, S; Yuan, M; Zhang, R | 1 |
| Gao, F; Jia, X; Li, Z; Peng, X; Tian, X; Zhang, A | 1 |
| Jia, L; Li, Y; Qi, P; Tang, R; Zheng, J | 1 |
| Du, H; Guo, LL; Kong, YR; Lu, QH; Ma, WH; Wang, X; Wei, FT; Xu, DL; Zhang, JB; Zhang, XG | 1 |
| Jin, W; Li, S; Liang, H; Liang, Y; Lin, G; Nie, R; Zhang, W; Zhang, Z | 1 |
| Cao, Q; Hu, B; Ji, A; Li, X; Song, S; Xiao, H; Yang, Q; Zhang, Q; Zhao, J | 1 |
| Deng, Y; Li, X; Liu, W; Ni, L; Pan, J; Wei, Y; Xu, B; Yang, T | 1 |
| Hua, Z; Wei, P | 1 |
| Bosnjak, M; Harhaji-Trajkovic, L; Kosic, M; Kravic-Stevovic, T; Mircic, A; Paunovic, V; Ristic, B; Stevanovic, D; Trajkovic, V | 1 |
| Koelink, PJ; Prins, MMC; Tjabringa, GS; van de Graaf, SFJ; van Roest, M; Vermeulen, JLM; Wildenberg, ME | 1 |
| Doran, SJ; Li, J; McCullough, LD; Moruno-Manchon, JF; O'Keefe, LM; Patel, AR; Patrizz, AN; Tsvetkov, AS; Venna, VR | 1 |
| Chen, G; Chen, J; Dong, Z; Kang, J; Liu, D | 1 |
| Cui, J; Li, Q; Qiao, T; Yu, X; Zhao, P; Zhao, Y; Zhong, DB | 1 |
| Guo, Q; Liu, Z; Smith, WW; Wang, B; Wang, X; Zhu, Y | 1 |
| Akopyan, AA; Dubrovina, NI; Ovsyukova, MV; Pupyshev, AB; Tenditnik, MV; Tikhonova, MA | 1 |
| Chen, X; Fan, Y; Gao, C; Gao, Y; Li, D; Li, LL; Luo, C; Rui, T; Shen, H; Tao, L; Wang, H; Wang, T; Wang, Z; Xia, C; Yao, Y; Zhang, J; Zhang, M | 1 |
| Cao, L; Chen, M; Furlong, F; Guo, X; Li, X; Meng, Z; Ren, Y; Wang, L; Wu, X; Xu, K; Zhang, Q; Zheng, S | 1 |
| Chen, Y; Cheng, H; Liu, Y; Meng, Y; Shi, J; Wu, F; Wu, Y | 1 |
| André, H; Cammalleri, M; Canovai, A; Dal Monte, M; Kvanta, A; Lardner, E; Pesce, NA; Plastino, F | 1 |
| Banerjee, A; Bhutda, S; Ghosh, S; Hiray, A; Santra, S; Sinha, AR | 1 |
| Bao, J; Cheng, X; Wang, X; Wang, Y; Wu, J; Wu, L; Xu, S; Yu, H; Zhang, L | 1 |
| Cao, Y; Che, D; Dai, F; Fan, R; Feng, Y; Gao, L; Gao, M; Ge, C; Li, J; Wang, C; Wang, S; Wang, Y; Xie, S; Xu, X | 1 |
| Chen, TY; Smartt, CT | 1 |
| Jiao, J; Wang, H; Wang, Y; Yue, J | 1 |
| Arneson-Wissink, PC; Bamlet, WR; Cho, DS; Dasgupta, A; Doles, JD; Ducharme, AM; Fernandez-Zapico, ME; Hogenson, TL; Krueger, EW; Razidlo, GL; Schmitt, RE; Zhang, L | 1 |
| Tang, C; Wang, X; Zhang, S | 1 |
| Chen, W; Han, W; He, Q; He, X; Huang, J; Yang, M; Yu, W | 1 |
| Jamal, MA; Jiao, D; Qing, Y; Wei, HJ; Xiong, Z; Xu, A; Xu, K; Zhao, H; Zhao, HY; Zhu, W; Zou, D | 1 |
| Shang, Y; Yang, N | 1 |
| Byeon, S; Choi, SK; Haam, CE; Kwon, Y; Lee, YH | 1 |
10 review(s) available for adenine and 3-methyladenine
| Article | Year |
|---|---|
Human nitrosamine exposure: recent dosimetry methods and applications.
Topics: Adenine; Biomarkers; Carcinogens; DNA Damage; Humans; Nitrosamines; Nitroso Compounds; Tyrosine | 1991 |
Exposure of humans to endogenous N-nitroso compounds: implications in cancer etiology.
Topics: Adenine; Bacterial Infections; Esophageal Neoplasms; Gastric Mucosa; Humans; Kinetics; Methylation; Neoplasms; Nicotiana; Nitrosamines; Nitrosation; Nitroso Compounds; Parasitic Diseases; Plants, Toxic; Stomach Neoplasms | 1990 |
Enhanced repair of O6-alkylguanine in mammalian tissues.
Topics: 2-Acetylaminofluorene; Adenine; Aflatoxin B1; Aflatoxins; Alkylating Agents; Alkylation; Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Hepatectomy; Liver; Methylnitrosourea; Mice; Rats; Rodentia; Species Specificity | 1984 |
Urinary markers for exposures to alkylating or nitrosating agents.
Topics: Adenine; Alkylating Agents; Animals; Biomarkers; Dimethylnitrosamine; DNA Damage; Humans; Nitric Oxide; Nitrosamines; Nitroso Compounds; Risk Factors; Stomach Neoplasms; Tyrosine | 1993 |
DNA methylation in ciliates: implications in differentiation processes.
Topics: 5-Methylcytosine; Adenine; Animals; Azacitidine; Cell Differentiation; Cell Nucleus; Ciliophora; Cytosine; DNA Methylation; DNA Modification Methylases; DNA, Protozoan; Gene Expression Regulation; Gene Expression Regulation, Developmental; Paramecium; Protozoan Proteins; Tetrahymena | 2000 |
Base excision repair in nuclear and mitochondrial DNA.
Topics: Adenine; Aging; Animals; Base Sequence; Cell Line; Cell Nucleus; Cell-Free System; DNA; DNA Damage; DNA Glycosylases; DNA Polymerase beta; DNA Repair; DNA-Formamidopyrimidine Glycosylase; DNA, Mitochondrial; Guanine; Hypoxanthine; Lymphocytes; Mammals; Mice; Mitochondria; Molecular Sequence Data; N-Glycosyl Hydrolases; Oxidants; Oxidation-Reduction; Oxidative Stress; Point Mutation; Proliferating Cell Nuclear Antigen; Rats; Thymine | 2001 |
The biological effects of N3-methyladenine.
Topics: Adenine; Alkylating Agents; Alkylation; Animals; Base Sequence; DNA Damage; DNA Methylation; Escherichia coli; Methyl Methanesulfonate; Mice; Models, Chemical; Molecular Sequence Data; Mutagenesis; Mutation; Netropsin; Saccharomyces cerevisiae | 2004 |
Molecular crosstalk between the proteasome, aggresomes and autophagy: translational potential and clinical implications.
Topics: Adenine; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Chloroquine; Clinical Trials as Topic; Drug Resistance, Neoplasm; Drug Synergism; Forecasting; Humans; Inclusion Bodies; Medical Oncology; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; Translational Research, Biomedical; Ubiquitin | 2012 |
Inhibition of autophagy enhances heat-induced apoptosis in human non-small cell lung cancer cells through ER stress pathways.
Topics: A549 Cells; Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Flow Cytometry; Hot Temperature; Humans; Hyperthermia, Induced; Immunohistochemistry; In Situ Nick-End Labeling; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Phosphorylation; RNA, Small Interfering | 2016 |
New Insight into Triple-Negative Breast Cancer Therapy: The Potential Roles of Endoplasmic Reticulum Stress and Autophagy Mechanisms.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drug Design; Endoplasmic Reticulum Stress; Female; Humans; Phytochemicals; Signal Transduction; Triple Negative Breast Neoplasms | 2021 |
1207 other study(ies) available for adenine and 3-methyladenine
| Article | Year |
|---|---|
Responsiveness of RNA degradation to amino acids in cultured rat hepatocytes: comparison with isolated rat hepatocytes.
Topics: Adenine; Amino Acids; Animals; Cell Count; Cells, Cultured; Culture Media; Kinetics; Liver; Male; Microscopy, Electron; Orotic Acid; Radioactivity; Rats; RNA | 1992 |
Both purified human 1,N6-ethenoadenine-binding protein and purified human 3-methyladenine-DNA glycosylase act on 1,N6-ethenoadenine and 3-methyladenine.
Topics: Adenine; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Humans; N-Glycosyl Hydrolases; Placenta; Substrate Specificity | 1992 |
Turnover of peroxisomal vesicles by autophagic proteolysis in cultured fibroblasts from Zellweger patients.
Topics: Adenine; Autophagy; Cell Line; Fibroblasts; Fluorescent Antibody Technique; Humans; Hydrolases; Leupeptins; Lysosomes; Membrane Proteins; Microbodies; Zellweger Syndrome | 1992 |
Defective DNA injection by alkylated and nonalkylated bacteriophage T7.
Topics: Adenine; Alkylation; Blotting, Southern; DNA Repair; DNA, Viral; Methyl Methanesulfonate; Restriction Mapping; Rifampin; T-Phages | 1992 |
Toxin-induced cell lysis: protection by 3-methyladenine and cycloheximide.
Topics: Abrin; Adenine; Animals; Bacterial Toxins; Cell Death; Cell Membrane Permeability; Cells, Cultured; Chromatin; Cycloheximide; DNA Damage; Dogs; Dose-Response Relationship, Drug; In Vitro Techniques; Microscopy, Electron; Phagocytosis; Proteins; Ricin; Rubidium; Shiga Toxins; Toxins, Biological; Vero Cells | 1992 |
Human cDNA expressing a functional DNA glycosylase excising 3-methyladenine and 7-methylguanine.
Topics: Adenine; Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Line; Cloning, Molecular; DNA Glycosylases; DNA Repair; DNA, Neoplasm; Escherichia coli; Gene Library; Humans; Kinetics; Liver Neoplasms; Molecular Sequence Data; N-Glycosyl Hydrolases; Rats; Sequence Homology, Nucleic Acid; Substrate Specificity | 1991 |
Both endocytic and endogenous protein degradation in fibroblasts is stimulated by serum/amino acid deprivation and inhibited by 3-methyladenine.
Topics: Adenine; Adenosine Triphosphate; alpha-Macroglobulins; Amino Acids; Animals; Cell Line; Cricetinae; Culture Media; Endocytosis; Epidermal Growth Factor; Fibroblasts; Kidney; Kinetics; Protein Biosynthesis; Proteins; Trypsin | 1990 |
Calcium-regulated secretion of tissue plasminogen activator and parathyroid hormone from human parathyroid cells.
Topics: Adenine; Adenoma; Calcium; Chloroquine; Humans; Immune Sera; In Vitro Techniques; Kinetics; Parathyroid Glands; Parathyroid Hormone; Parathyroid Neoplasms; Subcellular Fractions; Tissue Plasminogen Activator | 1992 |
3-Methyladenine mutagenesis under conditions of SOS induction in Escherichia coli.
Topics: Adenine; Base Sequence; DNA; Escherichia coli; Methylnitrosourea; Molecular Sequence Data; Mutagenesis; Plasmids; SOS Response, Genetics | 1991 |
The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress.
Topics: Adenine; Amino Acid Sequence; Animals; Cell Line; Cycloheximide; Ligases; Lysosomes; Molecular Sequence Data; Mutation; Proteins; Stress, Physiological; Temperature; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases | 1991 |
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Topics: Adenine; Alkylating Agents; Animals; Cytochrome b Group; DNA; Dose-Response Relationship, Drug; Glucagon; Glucose; Guanine; Immunoblotting; Insulin; Islets of Langerhans; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mitochondria; RNA, Messenger; Streptozocin | 1991 |
The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins.
Topics: Adenine; Cells, Cultured; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Hydrolysis; Ligases; Lysosomes; Proteins; Puromycin; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins; Vacuoles | 1991 |
A rapid gas chromatography-mass spectrometry method for the determination of urinary 3-methyladenine: application in human subjects.
Topics: Adenine; Adolescent; Chromatography, Affinity; Esophageal Neoplasms; Gas Chromatography-Mass Spectrometry; Humans | 1991 |
Tandem mass spectrometric approaches for determining exposure to alkylating agents.
Topics: Adenine; Alkylating Agents; Environmental Monitoring; Guanine; Humans; Mass Spectrometry | 1991 |
Comparison of urinary nitrate, N-nitrosoproline, 7-methylguanine and 3-methyladenine levels in a human population at risk for gastric cancer.
Topics: Adenine; Guanine; Humans; Nitrates; Nitrosamines; Risk; Stomach Neoplasms | 1991 |
Cloning and expression in Escherichia coli of a human cDNA encoding the DNA repair protein N-methylpurine-DNA glycosylase.
Topics: Adenine; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Genes, Bacterial; Guanine; HeLa Cells; Humans; Molecular Sequence Data; N-Glycosyl Hydrolases; Rats; Restriction Mapping; RNA, Messenger; Sequence Homology, Nucleic Acid | 1991 |
Effects of insulin on the synthesis, intracellular degradation, and secretion of parathormone.
Topics: Acid Phosphatase; Adenine; Animals; Calcium; Calcium-Binding Proteins; Cathepsin B; Cattle; Cells, Cultured; Chromogranin A; Chromogranins; Glucuronidase; Insulin; Kinetics; Lysosomes; Parathyroid Glands; Parathyroid Hormone; Protein Biosynthesis | 1991 |
Urinary excretion of nitrate, N-nitrosoproline, 3-methyladenine, and 7-methylguanine in a Colombian population at high risk for stomach cancer.
Topics: Adenine; Colombia; Guanine; Humans; Nitrates; Nitrosamines; Regression Analysis; Risk Factors; Stomach Neoplasms | 1991 |
Secretion of plasminogen activator from bovine parathyroid cells.
Topics: Adenine; Amiloride; Animals; Calcitriol; Calcium; Cattle; Cells, Cultured; Chloroquine; Fibrin; Hydrocortisone; Microsomes; Molecular Weight; Oligopeptides; Organelles; Parathyroid Glands; Parathyroid Hormone; Plasminogen Activators; Plasminogen Inactivators; Urokinase-Type Plasminogen Activator | 1990 |
The determination of urinary 3-methyladenine by immunoaffinity chromatography-monoclonal antibody-based ELISA: use in human biomonitoring studies.
Topics: Adenine; Animals; Antibodies, Monoclonal; Carcinogens; Chromatography, Affinity; Cross Reactions; Diet; Environmental Monitoring; Enzyme-Linked Immunosorbent Assay; Humans; Mice; Mice, Inbred BALB C | 1990 |
Monoclonal antibodies for the specific detection of 3-alkyladenines in nucleic acids and body fluids.
Topics: Adenine; Animals; Antibodies, Monoclonal; Body Fluids; Cross Reactions; DNA; Enzyme-Linked Immunosorbent Assay; Female; Humans; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Conformation; Radioimmunoassay; Rats; Rats, Inbred Strains | 1990 |
Cloning and expression in Escherichia coli of a gene for an alkylbase DNA glycosylase from Saccharomyces cerevisiae; a homologue to the bacterial alkA gene.
Topics: Adenine; Amino Acid Sequence; Base Sequence; Cloning, Molecular; DNA Glycosylases; DNA Repair; Drug Resistance; Escherichia coli; Gene Expression; Genes, Bacterial; Genes, Fungal; Guanine; Methyl Methanesulfonate; Molecular Sequence Data; N-Glycosyl Hydrolases; Open Reading Frames; Restriction Mapping; Saccharomyces cerevisiae; Sequence Homology, Nucleic Acid | 1990 |
Effects of vinblastine, leucine, and histidine, and 3-methyladenine on autophagy in Ehrlich ascites cells.
Topics: Adenine; Animals; Autophagy; Carcinoma, Ehrlich Tumor; Cell Survival; Child; Histidine; Humans; Leucine; Microscopy, Electron; Phagocytosis; Tumor Cells, Cultured; Vinblastine | 1990 |
Autophagic degradation of protein generates a pool of ferric iron required for the killing of cultured hepatocytes by an oxidative stress.
Topics: Adenine; Amino Acids; Animals; Ascorbic Acid; Autophagy; Benzyl Alcohol; Benzyl Alcohols; Cell Survival; Cells, Cultured; Colchicine; Deferoxamine; Ferric Compounds; Ferritins; Liver; Methylamines; Oligomycins; Oligopeptides; Oxidation-Reduction; Peroxides; Phagocytosis; Proteins; Rats; Rats, Inbred Strains; tert-Butylhydroperoxide | 1990 |
Inhibitors of cellular proteolysis cause increased secretion from parathyroid cells.
Topics: 1-Deoxynojirimycin; Adenine; Animals; Calcium; Calcium-Binding Proteins; Cattle; Cells, Cultured; Chloroquine; Chromogranin A; Chromogranins; Exocytosis; Glucosamine; Parathyroid Glands; Parathyroid Hormone; Protease Inhibitors; Radioimmunoassay | 1989 |
Experimental characterization of the autophagic-lysosomal pathway in isolated rat hepatocytes.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Endocytosis; Hot Temperature; Liver; Lysosomes; Methods; Phagocytosis; Rats; Sucrose; Vacuoles | 1989 |
Release of chloroethyl ethyl sulfide-modified DNA bases by bacterial 3-methyladenine-DNA glycosylases I and II.
Topics: Adenine; Alkylating Agents; Alkylation; Chromatography, High Pressure Liquid; DNA; DNA Glycosylases; Escherichia coli; Methylnitrosourea; Mustard Compounds; Mustard Gas; N-Glycosyl Hydrolases | 1989 |
Effects of inhibitors on aldolase breakdown after its microinjection into HeLa cells.
Topics: Adenine; Ammonium Chloride; Ethylmaleimide; Fructose-Bisphosphate Aldolase; HeLa Cells; Humans; Insulin; Leupeptins; Microinjections | 1989 |
Chromatographic detection of 7-methyladenine in urine of rats administered N-methylnitrosourea: a potential marker for monitoring exposure to methylating carcinogens.
Topics: Adenine; Chromatography, High Pressure Liquid; Methionine; Methylnitrosourea; Sulfuric Acid Esters | 1989 |
Energy dependence of different steps in the autophagic-lysosomal pathway.
Topics: Adenine; Adenosine Triphosphate; Animals; Atractyloside; Autophagy; Cell Compartmentation; Energy Metabolism; Lactose; Lysosomes; Male; Phagocytosis; Propylamines; Rats; Rats, Inbred Strains; Sucrose; Vinblastine | 1989 |
Repair of N-methylpurines in specific DNA sequences in Chinese hamster ovary cells: absence of strand specificity in the dihydrofolate reductase gene.
Topics: Adenine; Animals; Cell Line; Cricetinae; Deoxyribonucleases, Type II Site-Specific; Dimethyl Sulfoxide; DNA; DNA Damage; DNA Probes; DNA Repair; Electrophoresis, Agar Gel; Exons; Guanine; Hot Temperature; Hydrolysis; Nucleic Acid Hybridization; RNA Probes; Sulfuric Acid Esters; Tetrahydrofolate Dehydrogenase; Transcription, Genetic | 1989 |
Reduced autophagic activity, improved protein balance and enhanced in vitro survival of hepatocytes isolated from carcinogen-treated rats.
Topics: 2-Acetylaminofluorene; Adenine; Adenosine Triphosphatases; Amino Acids; Animals; Autophagy; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; Diethylnitrosamine; gamma-Glutamyltransferase; Hepatectomy; Histocytochemistry; In Vitro Techniques; Kinetics; Liver; Lysosomes; Male; Phagocytosis; Proteins; Rats; Rats, Inbred Strains; Sucrose | 1985 |
Urinary excretion of 3-methyladenine and 1-methylnicotinamide by rats, following administration of [methyl-14C]methyl methanesulphonate and comparison with administration of [14C]methionine or formate.
Topics: Adenine; Alkylation; Animals; Chromatography, Ion Exchange; Female; Formates; Methionine; Methyl Methanesulfonate; Methylation; Niacinamide; Rats | 1985 |
Regulation of the breakdown rates of biotin-containing proteins in Swiss 3T3-L1 cells.
Topics: Adenine; Biotin; Cell Line; Electrophoresis, Polyacrylamide Gel; Insulin; Leucine; Leupeptins; Proteins | 1988 |
Induction of SOS and adaptive responses by alkylating agents in Escherichia coli mutants deficient in 3-methyladenine-DNA glycosylase activities.
Topics: Adaptation, Biological; Adenine; Alkylating Agents; beta-Galactosidase; DNA Glycosylases; DNA Repair; Escherichia coli; Methyltransferases; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; SOS Response, Genetics | 1987 |
Urinary excretion of 3-methyladenine in humans as a marker of nucleic acid methylation.
Topics: Adenine; DNA; Enzyme-Linked Immunosorbent Assay; Humans; Methylation | 1988 |
Regulation of lysosomal proteolysis in burn injury.
Topics: Acetylglucosaminidase; Adenine; Animals; Burns; Cathepsins; Endocytosis; Lysosomes; Male; Mannose; Muscles; Peptide Hydrolases; Phenylalanine; Rats; Rats, Inbred Strains | 1987 |
3-Methyladenine, an inhibitor of autophagy, has multiple effects on metabolism.
Topics: Adenine; Animals; Cells, Cultured; Chloroquine; Glucagon; Glucose; Hydrogen-Ion Concentration; Kinetics; Liver; Liver Glycogen; Lysosomes; Male; Methylamines; Mitochondria, Liver; Rats; Rats, Inbred Strains | 1988 |
The isolation and characterization of an alkylating-agent-sensitive yeast mutant, ngs1.
Topics: Adenine; Alkylating Agents; DNA Repair; Genes, Fungal; Guanine; Methylnitronitrosoguanidine; Mutation; Saccharomyces cerevisiae; Sulfuric Acid Esters | 1986 |
O6-methylguanine specifically induces AT----GC transition mutations.
Topics: 5-Methylcytosine; Adenine; Alkylation; Base Composition; Cytosine; DNA Damage; DNA, Bacterial; Escherichia coli; Guanine; Hypoxanthine; Hypoxanthines; Mutation | 1987 |
The determination of urinary 3-methyladenine in humans as a potential monitor of exposure to methylating agents.
Topics: Adenine; Alkylating Agents; Carcinogens; DNA; Gas Chromatography-Mass Spectrometry; Humans; Male; Methylation; Monitoring, Physiologic | 1987 |
Transfer of human genes conferring resistance to methylating mutagens, but not to UV irradiation and cross-linking agents, into Chinese hamster ovary cells.
Topics: Adenine; Alkylating Agents; Animals; Cricetinae; Cross-Linking Reagents; DNA Repair; Genes; Guanine; Humans; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transfection; Ultraviolet Rays | 1987 |
Excretion of methylated nucleic acid bases as an indicator of exposure to nitrosatable drugs.
Topics: Adenine; Animals; Female; Guanine; Methylation; Nitroso Compounds; Nucleic Acids; Rats | 1987 |
Specific DNA alkylation damage and its repair in carcinogen-treated rat liver and brain.
Topics: Adenine; Alkylating Agents; Animals; Brain; Carcinogens; DNA; DNA Repair; Guanine; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methyl Methanesulfonate; Methylnitrosourea; Rats; Rats, Inbred Strains | 1986 |
Use of a hydrolysable probe, [14C]lactose, to distinguish between pre-lysosomal and lysosomal steps in the autophagic pathway.
Topics: Adenine; Animals; Autophagy; Chloroquine; Hydrolysis; Lactose; Liver; Lysosomes; Male; Phagocytosis; Phagosomes; Rats; Rats, Inbred Strains; Sucrose; Vinblastine | 1986 |
Secretion-coupled protein degradation: studies on mammary casein.
Topics: Adenine; Amino Acids; Animals; Biological Transport; Caseins; Colchicine; Cytochalasin B; Female; Leupeptins; Mammary Glands, Animal; Organ Culture Techniques; Rabbits; Tunicamycin | 1986 |
DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells.
Topics: Adenine; Alkylating Agents; Alkylation; Cell Survival; DNA Repair; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Purines; Sister Chromatid Exchange | 1987 |
Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine.
Topics: Adenine; Animals; Calcium; Dantrolene; Female; Leupeptins; Methylamines; Muscle Proteins; Muscles; Potassium; Rats; Rats, Inbred Strains; Thyroxine | 1986 |
Regulation of protein breakdown by epidermal growth factor in A431 cells.
Topics: Adenine; Ammonium Chloride; Autolysis; Carcinoma, Squamous Cell; Cell Line; Cycloheximide; Epidermal Growth Factor; Fibroblasts; Humans; Hydrogen-Ion Concentration; Insulin; Leupeptins; Lung; Proteins; Time Factors; Vinblastine | 1985 |
The role of lysosomes in the degradation of myofibrillar and non-myofibrillar proteins in heart.
Topics: Adenine; Animals; Chloroquine; Fetus; Insulin; Kinetics; Leupeptins; Lysosomes; Mice; Myocardium; Myofibrils; Proteins | 1985 |
Separation of naturally occurring or induced methylated nucleobases of DNA by reversed-phase high-performance liquid chromatography.
Topics: Adenine; Animals; Cattle; Chromatography, High Pressure Liquid; Cytosine; DNA; Euglena gracilis; Hydrolysis; Methylnitrosourea; Spectrophotometry, Infrared; Thymus Gland | 1985 |
Regulation of protein degradation in muscle by calcium. Evidence for enhanced nonlysosomal proteolysis associated with elevated cytosolic calcium.
Topics: Adenine; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Cytosol; Dantrolene; Female; Gallic Acid; In Vitro Techniques; Mersalyl; Methylamines; Muscle Proteins; Muscles; Potassium Chloride; Prostaglandins; Protease Inhibitors; Rats; Rats, Inbred Strains | 1985 |
Use of [3H]raffinose as a specific probe of autophagic sequestration.
Topics: Adenine; Animals; Autophagy; Digitonin; Liver; Lysosomes; Male; Mitochondria, Liver; Oligosaccharides; Phagocytosis; Phagosomes; Raffinose; Rats; Rats, Inbred Strains; Sucrose | 1986 |
Repair of chemical carcinogen-induced damage in DNA of human lymphocytes and lymphoid cell lines--studies of the kinetics of removal of O6-methylguanine and 3-methyladenine.
Topics: Adenine; Autoimmune Diseases; Carcinogens; Cell Line; DNA Repair; Guanine; Humans; Kinetics; Lymphocytes; Mathematics; Models, Chemical | 1986 |
Purification and characterization of 3-methyladenine-DNA glycosylase from calf thymus.
Topics: Adenine; Animals; Cattle; Chemical Phenomena; Chemistry, Physical; Chromatin; DNA Glycosylases; Guanine; Hot Temperature; Isoelectric Point; Kinetics; Molecular Weight; N-Glycosyl Hydrolases; Substrate Specificity; Sulfhydryl Compounds; Thymus Gland | 1985 |
Conversion of dense lysosomes into light lysosomes during hepatocytic autophagy.
Topics: Adenine; Animals; Autophagy; Centrifugation, Density Gradient; Liver; Lysosomes; Male; Mitochondria; Phagocytosis; Rats; Rats, Inbred Strains; Sucrose | 1985 |
Autophagic sequestration of [14C]sucrose introduced into isolated rat hepatocytes by electrical and non-electrical methods.
Topics: Adenine; Animals; Cell Compartmentation; Cell Membrane Permeability; Centrifugation, Density Gradient; Electric Stimulation; Kinetics; Liver; Male; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Sucrose | 1985 |
DNA sequence has an effect on the extent and kinds of alkylation of DNA by a potent carcinogen.
Topics: Adenine; Alkylation; Animals; Base Sequence; Cattle; DNA; Guanine; Methylnitrosourea; Polydeoxyribonucleotides; Structure-Activity Relationship; Thymus Gland; Tritium | 1985 |
Autophagic-lysosomal and mitochondrial sequestration of [14C]sucrose. Density gradient distribution of sequestered radioactivity.
Topics: Acid Phosphatase; Adenine; Animals; Autophagy; Centrifugation, Density Gradient; Chromatography, Gel; Digitonin; In Vitro Techniques; Lysosomes; Male; Metrizamide; Mitochondria, Liver; Rats; Rats, Inbred Strains; Subcellular Fractions; Sucrose; Temperature | 1985 |
Use of digitonin extraction to distinguish between autophagic-lysosomal sequestration and mitochondrial uptake of [14C]sucrose in hepatocytes.
Topics: Adenine; Amino Acids; Animals; Autophagy; Digitonin; In Vitro Techniques; Liver; Lysosomes; Male; Mitochondria, Liver; Phagocytosis; Rats; Rats, Inbred Strains; Sucrose | 1985 |
Autophagy and protein degradation in isolated rat hepatocytes.
Topics: Adenine; Animals; Autolysis; Cell Compartmentation; Cell Fractionation; Liver; Lysosomes; Mitochondria, Liver; Phagocytosis; Proteins; Rats; Sucrose | 1985 |
3-Methyladenine residues in DNA induce the SOS function sfiA in Escherichia coli.
Topics: Adenine; Alkylating Agents; Bacteriophage lambda; DNA Glycosylases; DNA Repair; DNA, Bacterial; Escherichia coli; Genes, Bacterial; Genotype; N-Glycosyl Hydrolases; Species Specificity | 1984 |
Enzymatic excision of 3-methyladenine and 7-methylguanine by a rat liver nuclear fraction.
Topics: Adenine; Animals; Cell Nucleus; Chromatography, Affinity; DNA Glycosylases; Endonucleases; Guanine; Kinetics; Liver; Molecular Weight; N-Glycosyl Hydrolases; Rats; Substrate Specificity | 1981 |
The release of 3-methyladenine from nucleosomal DNA by a 3-methyladenine DNA glycosylase.
Topics: Adenine; Animals; Chickens; DNA; DNA Glycosylases; DNA Repair; Erythrocytes; Escherichia coli; Ethidium; Female; Kinetics; Microscopy, Electron; N-Glycosyl Hydrolases; Nucleosomes | 1983 |
Urinary excretion of methylated purines and 1-methyl-nicotinamide following administration of methylating carcinogens.
Topics: 1,2-Dimethylhydrazine; Adenine; Alkylating Agents; Animals; Carcinogens; Dimethylhydrazines; Dimethylnitrosamine; Guanine; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Niacinamide; Rats | 1980 |
Amino acid control of protein degradation in normal and leukemic human lymphocytes.
Topics: Adenine; Amino Acids; Autophagy; Humans; Leukemia, Lymphoid; Leupeptins; Lymphocytes; Lysosomes; Neoplasm Proteins; Phagocytosis; Propylamines; Proteins | 1984 |
Enhancement of DNA-mediated gene transfer by inhibitors of autophagic-lysosomal function.
Topics: Adenine; Ammonium Chloride; Animals; Autophagy; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; DNA; Genetic Engineering; Lysosomes; Membrane Fusion; Rats; Time Factors; Transfection; Transformation, Genetic | 1984 |
Release of 3-methyladenine from linker and core DNA of chromatin by a purified DNA glycosylase.
Topics: Adenine; Carbon Radioisotopes; Chromatin; DNA Glycosylases; DNA, Neoplasm; HeLa Cells; Humans; Methylnitrosourea; N-Glycosyl Hydrolases; Nucleosomes; Tritium | 1983 |
Paradoxical stimulation by amino acids of the degradation of [35S]methionine-labelled, short-lived protein in isolated rat hepatocytes.
Topics: Adenine; Amino Acids; Animals; Liver; Lysosomes; Male; Methionine; Propylamines; Proteins; Rats | 1983 |
Amino acid control of autophagic sequestration and protein degradation in isolated rat hepatocytes.
Topics: Acid Phosphatase; Adenine; Amino Acids; Animals; Carbon Radioisotopes; Cycloheximide; Electric Stimulation; In Vitro Techniques; Liver; Lysosomes; Male; Protein Biosynthesis; Proteins; Rats; Rats, Inbred Strains; Sucrose | 1984 |
Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.
Topics: Adenine; Aflatoxin B1; Aflatoxins; Animals; Dimethylnitrosamine; DNA Repair; Guanine; Liver; Male; Rats; Stimulation, Chemical | 1981 |
O6-methylguanine, but not N7-methylguanine or N3-methyladenine, induces gene mutations, sister-chromatid exchanges and chromosomal aberrations in Chinese hamster cells.
Topics: Adenine; Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Guanine; Karyotyping; Mutation; Sister Chromatid Exchange | 1983 |
O6-Methylguanine removal by competent and incompetent human lymphoblastoid lines from the same male individual.
Topics: Adenine; Cell Division; Cell Line; Chromosome Aberrations; Guanine; Humans; Karyotyping; Lymphocyte Activation; Lymphocytes; Male; Methylnitronitrosoguanidine | 1983 |
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.
Topics: Adenine; Animals; Brain; DNA; Female; Fetus; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Purines; Rats; Time Factors | 1983 |
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes.
Topics: Adenine; Adenosine Triphosphate; Amino Acids; Animals; Autolysis; Cells, Cultured; Liver; Lysosomes; Phagocytosis; Protein Biosynthesis; Proteins; Rats | 1982 |
Enzymatic release of 7-methylguanine from methylated DNA by rodent liver extracts.
Topics: Adenine; Animals; Cattle; Cricetinae; DNA; DNA Glycosylases; Escherichia coli; Guanine; Kinetics; Liver; Methylation; N-Glycosyl Hydrolases; Rats; Thymus Gland | 1981 |
Adaptation to alkylation resistance involves the induction of a DNA glycosylase.
Topics: Adenine; Alkylating Agents; DNA Glycosylases; DNA Repair; Enzyme Induction; Escherichia coli; Genes, Regulator; Mutation; N-Glycosyl Hydrolases | 1982 |
Two DNA glycosylases in Escherichia coli which release primarily 3-methyladenine.
Topics: Adenine; Bacterial Proteins; DNA Glycosylases; Escherichia coli; Guanine; Hot Temperature; Isoelectric Focusing; Kinetics; Molecular Weight; N-Glycosyl Hydrolases; Substrate Specificity | 1982 |
Cellular defense mechanisms against alkylation of DNA.
Topics: Adenine; Alkylation; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Methyltransferases; Mutation; N-Glycosyl Hydrolases; S-Adenosylmethionine | 1982 |
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro.
Topics: Adenine; Animals; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Repair; Guanine; In Vitro Techniques; Methylation; S-Adenosylmethionine; Scintillation Counting; Spectrophotometry, Ultraviolet | 1982 |
Dose- and cell cycle-dependent O6-methylguanine elimination from DNA in regenerating rat liver after [14C]dimethylnitrosamine injection.
Topics: Adenine; Animals; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Guanine; Interphase; Liver; Liver Regeneration; Male; Rats | 1982 |
Partial purification and characterization of 3-methyladenine-DNA glycosylase from human placenta.
Topics: Adenine; Chromatography, High Pressure Liquid; DNA Glycosylases; Female; Guanine; Humans; N-Glycosyl Hydrolases; Placenta; Pregnancy; Substrate Specificity | 1982 |
Purification and properties of 3-methyladenine-DNA glycosylase from L-cells.
Topics: Adenine; Animals; DNA Glycosylases; DNA, Viral; Hydrogen-Ion Concentration; Kinetics; L Cells; Methylation; Mice; Molecular Weight; N-Glycosyl Hydrolases; Potassium Chloride; Substrate Specificity | 1981 |
Repair of 3-methyladenine and 7-methylguanine in nuclear DNA of Chlamydomonas: requirement for protein synthesis.
Topics: Adenine; Chlamydomonas; DNA; DNA Repair; Guanosine; Methyl Methanesulfonate; Molecular Weight; Mutagens | 1981 |
In vivo replication of hepatic deoxyribonucleic acid of rats treated with dimethylnitrosamine: presence of dimethylnitrosamine-induced O6-methylguanine, N7-methylguanine, and N3-methyladenine in the replicated hybrid deoxyribonucleic acid.
Topics: Adenine; Animals; Dimethylnitrosamine; DNA Replication; Guanine; Liver; Male; Nucleic Acid Hybridization; Rats | 1980 |
Urinary excretion of 3-methyladenine and 3-ethyladenine after controlled exposure to tobacco smoke.
Topics: Adenine; Adult; Environmental Exposure; Humans; Male; Smoking; Tobacco Smoke Pollution | 1995 |
Increased resistance of the Chinese hamster mutant irs1 cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes.
Topics: Adenine; Alkylating Agents; Animals; Cell Line; Cricetinae; Dexamethasone; DNA; DNA Glycosylases; DNA Repair; Drug Resistance; Escherichia coli; Ethyl Methanesulfonate; Methyl Methanesulfonate; N-Glycosyl Hydrolases; Rats; Transfection | 1993 |
Mechanism of toxicity of 3-methyladenine for bacteriophage T7.
Topics: Adenine; Alkylation; Bacteriophage T7; DNA Glycosylases; DNA Repair; DNA-Directed RNA Polymerases; DNA, Bacterial; DNA, Viral; Escherichia coli; Methyl Methanesulfonate; N-Glycosyl Hydrolases; Plasmids; RNA, Viral; Substrate Specificity; Templates, Genetic; Transcription, Genetic; Viral Proteins | 1993 |
Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes.
Topics: Adenine; Animals; Autophagy; Male; Phosphorylation; Polyenes; Proteins; Rats; Rats, Wistar; Ribosomal Protein S6; Ribosomal Proteins; Ribosomes; Sirolimus | 1995 |
3-Methyladenine and 7-methylguanine exhibit no preferential removal from the transcribed strand of the dihydrofolate reductase gene in Chinese hamster ovary B11 cells.
Topics: Adenine; Animals; Autoradiography; CHO Cells; Cricetinae; DNA Damage; Guanine; Tetrahydrofolate Dehydrogenase; Transcription, Genetic | 1995 |
3-Methyladenine inhibits transport from late endosomes to lysosomes in cultured rat and mouse fibroblasts.
Topics: 3T3 Cells; Adenine; Animals; Biological Transport; Biomarkers; Cathepsin L; Cathepsins; Cells, Cultured; Cyclic AMP; Cysteine Endopeptidases; Endopeptidases; Endosomes; Fibroblasts; Lysosomes; Mice; Rats; Time Factors | 1994 |
Cellular vacuoles induced by Helicobacter pylori originate from late endosomal compartments.
Topics: Adenine; Biomarkers; Cathepsin D; Colchicine; Fluorescent Antibody Technique; GTP-Binding Proteins; HeLa Cells; Helicobacter pylori; Humans; Immunoblotting; Isoquinolines; Kinetics; Nocodazole; Receptors, Transferrin; Vacuoles | 1994 |
DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the AlkA enzyme in Escherichia coli.
Topics: Adenine; Chromatography, Gel; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; DNA Glycosylases; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Genes, Bacterial; Kinetics; N-Glycosyl Hydrolases; Oxidation-Reduction; Thymine; Uracil | 1994 |
Purification and biochemical characterization of recombinant N-methylpurine-DNA glycosylase of the mouse.
Topics: Adenine; Amino Acid Sequence; Animals; DNA; DNA Glycosylases; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Guanine; Hydrogen-Ion Concentration; Kinetics; Magnesium Chloride; Methylation; Mice; Molecular Sequence Data; N-Glycosyl Hydrolases; Recombinant Proteins; Sodium Chloride; Spermine; Substrate Specificity | 1994 |
1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase).
Topics: Adenine; Alkylation; Base Sequence; DNA; DNA Glycosylases; Electrophoresis, Polyacrylamide Gel; Humans; Kinetics; Molecular Sequence Data; N-Glycosyl Hydrolases; Recombinant Proteins; Substrate Specificity | 1994 |
Inhibitors of endocytosis, endosome fusion, and lysosomal processing inhibit the intracellular proteolysis of the amyloid precursor protein.
Topics: Adenine; Amyloid beta-Protein Precursor; Animals; Chloroquine; Colchicine; Cytochalasin B; Endocytosis; Lysosomes; Monensin; Organelles; PC12 Cells; Rats | 1993 |
Genetic consequences of tolerance to methylation DNA damage in mammalian cells.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Aza Compounds; Base Sequence; Cell Survival; CHO Cells; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutation; Ouabain; Thioguanine | 1993 |
Autophagic degradation of N-linked glycoproteins is downregulated in differentiated human colon adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Asparagine; Autophagy; Carbon Radioisotopes; Carcinogens; Cell Differentiation; Cell Line; Chloroquine; Colonic Neoplasms; Ethers, Cyclic; Glycoproteins; Humans; Kinetics; Leucine; Lysosomes; Mannose; Okadaic Acid; Polysaccharides; Tritium; Tumor Cells, Cultured | 1993 |
Effects of intracellular amino acid concentrations, cyclic AMP, and dexamethasone on lysosomal proteolysis in primary cultures of perinatal rat hepatocytes.
Topics: Adenine; Amino Acids; Animals; Animals, Suckling; Bucladesine; Cells, Cultured; Cyclic AMP; Dexamethasone; Ligases; Liver; Lysosomes; Phosphoenolpyruvate Carboxykinase (GTP); Proteins; Rats; Rats, Wistar; RNA, Messenger; Weaning | 1993 |
Cloning and characterization of a mouse 3-methyladenine/7-methyl-guanine/3-methylguanine DNA glycosylase cDNA whose gene maps to chromosome 11.
Topics: Adenine; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Cell Nucleus; Chromosome Mapping; Chromosomes; Cloning, Molecular; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Gene Expression; Guanine; Humans; Mice; Molecular Sequence Data; N-Glycosyl Hydrolases; Rats; RNA, Messenger; Sequence Homology, Amino Acid | 1993 |
Immunoaffinity purification and gas chromatography-mass spectrometric quantification of 3-alkyladenines in urine: metabolism studies and basal excretion levels in man.
Topics: Adenine; Adult; Antibodies, Monoclonal; Deuterium; Diet; Female; Gas Chromatography-Mass Spectrometry; Humans; Immunosorbent Techniques; Male; Sepharose; Staphylococcal Protein A | 1993 |
The design of agents to control DNA methylation adducts. Enhanced major groove methylation of DNA by an N-methyl-N-nitrosourea functionalized phenyl neutral red intercalator.
Topics: Adenine; Circular Dichroism; DNA Adducts; DNA Methylation; Drug Design; Ethidium; Guanine; Intercalating Agents; Methylnitrosourea; Neutral Red; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1996 |
Effect of overexpression of E. coli 3-methyladenine-DNA glycosylase I (Tag) on survival and mutation induction in Salmonella typhimurium.
Topics: Adenine; DNA Glycosylases; Escherichia coli; Gene Expression Regulation, Bacterial; Genes, Bacterial; Guanine; Isopropyl Thiogalactoside; Mutagens; Mutation; N-Glycosyl Hydrolases; Nitrosourea Compounds; Salmonella typhimurium; SOS Response, Genetics; Sulfuric Acid Esters; Suppression, Genetic; Transformation, Genetic | 1996 |
Different efficiencies of the Tag and AlkA DNA glycosylases from Escherichia coli in the removal of 3-methyladenine from single-stranded DNA.
Topics: Adenine; Alkylation; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Escherichia coli; Methylation; N-Glycosyl Hydrolases; Poly A; Poly dA-dT | 1996 |
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
Topics: Adenine; Androstadienes; Animals; Autophagy; Cell Membrane; Cells, Cultured; Chromones; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; Liver; Male; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Signal Transduction; Starvation; Wortmannin | 1997 |
Inhibition of peroxisomal degradation by 3-methyladenine (3MA) in primary cultures of rat hepatocytes.
Topics: Adenine; Animals; Autophagy; Bezafibrate; Catalase; Cells, Cultured; Liver; Male; Microbodies; Microscopy, Electron; Rats; Rats, Wistar | 1997 |
Urinary excretion of 3-methyladenine after consumption of fish containing high levels of dimethylamine.
Topics: Adenine; Animals; Diet; Dimethylamines; Fishes; Food Preservation; Freezing; Humans; Methylamines; Nitrates; Nitrosamines; Nitroso Compounds | 1997 |
Evidence for a dual control of macroautophagic sequestration and intracellular trafficking of N-linked glycoproteins by the trimeric G(i3) protein in HT-29 cells.
Topics: Adenine; Autophagy; Brefeldin A; Cyclopentanes; Exocytosis; Glycoproteins; Golgi Apparatus; GTP-Binding Protein alpha Subunits, Gi-Go; HT29 Cells; Humans; Lysosomes; Mutation; Pertussis Toxin; Polysaccharides; Raffinose; Transfection; Virulence Factors, Bordetella | 1997 |
Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules.
Topics: Adenine; Ammonium Chloride; Animals; Antigen Presentation; Antigen-Presenting Cells; Autophagy; B-Lymphocytes; Cell Line; Complement C5; Fibroblasts; Histocompatibility Antigens Class II; Intracellular Fluid; Macrophages; Mice; Mice, Inbred A; Mice, Inbred BALB C; Rats; T-Lymphocytes; Transfection | 1997 |
MHC class II-associated invariant chain-induced enlarged endosomal structures: a morphological study.
Topics: Adenine; Antigens, CD; Brefeldin A; Cell Line; Chloroquine; Cyclopentanes; Endocytosis; Endosomes; Fibroblasts; HLA-DR alpha-Chains; HLA-DR Antigens; Humans; Immunohistochemistry; Leupeptins; Lysosomal Membrane Proteins; Lysosomes; Macromolecular Substances; Membrane Glycoproteins; Receptor, IGF Type 2; Recombinant Proteins; Transfection | 1997 |
Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells.
Topics: Adenine; Apoptosis; DNA Fragmentation; Drug Resistance, Neoplasm; Humans; Leukemia-Lymphoma, Adult T-Cell; Mitochondria; Mitochondrial Swelling; Recombinant Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Role of an antimalarial drug in diphosphatidylglycerol biosynthesis in rat liver hepatocytes.
Topics: Adenine; Animals; Antimalarials; Cardiolipins; Chloroquine; Glucose; In Vitro Techniques; Liver; Male; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome.
Topics: Adenine; Alkylating Agents; Animals; Apoptosis; Cell Line; Chromosome Aberrations; DNA Adducts; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; Mice; N-Glycosyl Hydrolases; Netropsin; Sister Chromatid Exchange; Tumor Suppressor Protein p53 | 1998 |
Repair in Escherichia coli alkB mutants of abasic sites and 3-methyladenine residues in DNA.
Topics: Adenine; Apurinic Acid; Bacterial Proteins; Bacteriophage lambda; Binding Sites; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; DNA Damage; DNA Repair; DNA, Bacterial; DNA, Viral; Escherichia coli; Escherichia coli Proteins; Indicators and Reagents; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Mixed Function Oxygenases; Mutagens; Mutation; Netropsin; Polynucleotides; Sulfuric Acid Esters; Virus Replication | 1998 |
Activity of Escherichia coli DNA-glycosylases on DNA damaged by methylating and ethylating agents and influence of 3-substituted adenine derivatives.
Topics: Adenine; Alkylating Agents; Bacterial Proteins; DNA; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Escherichia coli; Escherichia coli Proteins; Kinetics; Lipoproteins; N-Glycosyl Hydrolases | 1998 |
Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells.
Topics: Adenine; Base Sequence; Chromatin; DNA Adducts; DNA Damage; DNA Footprinting; DNA Glycosylases; DNA Repair; Exons; Fibroblasts; Guanine; Half-Life; Humans; Male; Molecular Sequence Data; N-Glycosyl Hydrolases; Phosphoglycerate Kinase; Promoter Regions, Genetic; Sulfuric Acid Esters | 1998 |
Tobacco BY-2 cells excise both 3-methyladenine and 7-methylguanine from methylated DNA.
Topics: Adenine; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; DNA; DNA Glycosylases; DNA Methylation; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; N-Glycosyl Hydrolases; Nicotiana; Plants, Toxic | 1998 |
Ubiquitinated aldolase B accumulates during starvation-induced lysosomal proteolysis.
Topics: Adenine; Amino Acid Sequence; Amino Acids; Animals; Antimalarials; Blood Proteins; Carcinoma, Hepatocellular; Cell Survival; Chloroquine; Cytosol; Fructose-Bisphosphate Aldolase; Kidney; Liver; Lysosomes; Molecular Sequence Data; Rats; Starvation; Tumor Cells, Cultured; Ubiquitins | 1999 |
Parasitophorous vacuoles of Leishmania mexicana acquire macromolecules from the host cell cytosol via two independent routes.
Topics: Adenine; Animals; Autophagy; Biological Transport, Active; Cysteine Endopeptidases; Cytosol; Dextrans; Female; In Vitro Techniques; Isoquinolines; Leishmania mexicana; Macromolecular Substances; Macrophages; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Vacuoles | 1999 |
Modulation of the toxic and mutagenic effects induced by methyl methanesulfonate in Chinese hamster ovary cells by overexpression of the rat N-alkylpurine-DNA glycosylase.
Topics: Adenine; Alkylating Agents; Animals; Base Pair Mismatch; CHO Cells; Cricetinae; Cricetulus; DNA Damage; DNA Glycosylases; DNA Ligases; DNA Methylation; DNA Repair; Enzyme Induction; Frameshift Mutation; Guanine; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Mutagenesis; Mutagens; N-Glycosyl Hydrolases; Rats; Recombinant Fusion Proteins; Transfection | 1999 |
DNA methylation by tert-butyl hydroperoxide-iron (II): a role for the transition metal ion in the production of DNA base adducts.
Topics: Adenine; Animals; Cattle; Chelating Agents; Copper; DNA Adducts; DNA Methylation; Electron Spin Resonance Spectroscopy; Free Radicals; Guanine; Iron; Molecular Structure; tert-Butylhydroperoxide | 1999 |
Relationship between DNA methylation and mutational patterns induced by a sequence selective minor groove methylating agent.
Topics: Adenine; Alkylating Agents; Alkylation; Base Sequence; DNA Methylation; DNA Mutational Analysis; Humans; Molecular Sequence Data; Netropsin; Tumor Suppressor Protein p53 | 1999 |
Differentiation-dependent inhibition of proteolysis by norepinephrine in brown adipocytes.
Topics: Adenine; Adipose Tissue, Brown; Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP; Insulin; Mice; Mice, Inbred Strains; Norepinephrine; Protease Inhibitors; Receptors, Adrenergic, beta | 1999 |
Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; Caspase Inhibitors; Cells, Cultured; Cysteine Proteinase Inhibitors; DNA Fragmentation; Mitochondria; Neurons; Rats; Rats, Wistar; Signal Transduction; Superior Cervical Ganglion | 1999 |
Evaluation of the alkaline comet assay and urinary 3-methyladenine excretion for monitoring DNA damage in melanoma patients treated with dacarbazine and tamoxifen.
Topics: Adenine; Adult; Aged; Antineoplastic Agents, Alkylating; Comet Assay; Dacarbazine; DNA Damage; Female; Humans; Lymphocytes; Male; Melanoma; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity; Skin Neoplasms | 2000 |
Intracellular protein degradation and autophagy in isolated pancreatic acini of the rat.
Topics: Adenine; Amines; Amino Acids; Animals; Autophagy; Cells, Cultured; Enzyme Inhibitors; Kinetics; Leupeptins; Lysosomes; Male; Microscopy, Electron; Pancreas; Protein Biosynthesis; Proteins; Rats; Rats, Long-Evans; Vinblastine | 2000 |
Contribution of base excision repair, nucleotide excision repair, and DNA recombination to alkylation resistance of the fission yeast Schizosaccharomyces pombe.
Topics: Adenine; Alkylating Agents; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Endodeoxyribonucleases; Fungal Proteins; Methyl Methanesulfonate; Models, Genetic; Mutagens; N-Glycosyl Hydrolases; Rad51 Recombinase; Recombination, Genetic; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Species Specificity | 2000 |
In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells.
Topics: Adenine; Animals; Cell Line; DNA Adducts; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; DNA Replication; Gene Deletion; Genotype; Guanine; Guanosine; Methylnitrosourea; Mice; Mice, Knockout; N-Glycosyl Hydrolases | 2000 |
Retention of mutant alpha(1)-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response.
Topics: Adenine; alpha 1-Antitrypsin; Animals; Autophagy; CHO Cells; Cricetinae; Endoplasmic Reticulum; Fibroblasts; Gene Expression; Humans; Liver; Liver Diseases; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Microsomes; Mutagenesis; Vacuoles; Vimentin | 2000 |
Autophagy in the epithelial cells of murine seminal vesicle in vitro. Formation of large sheets of nascent isolation membranes, sequestration of the nucleus and inhibition by wortmannin and 3-ethyladenine.
Topics: Adenine; Androstadienes; Animals; Autophagy; Cell Nucleus; Cell Size; Detergents; Endoplasmic Reticulum, Rough; Epithelial Cells; In Vitro Techniques; Intracellular Membranes; Male; Mice; Microscopy, Electron; Octoxynol; Phosphoinositide-3 Kinase Inhibitors; Seminal Vesicles; Vacuoles; Wortmannin | 2000 |
Lysosomal involvement in hepatocyte cytotoxicity induced by Cu(2+) but not Cd(2+).
Topics: Acridine Orange; Adenine; Animals; Aurothioglucose; Cadmium; Cell Death; Chloroquine; Copper; Endopeptidases; Enzyme Activation; Gentamicins; Leupeptins; Lipid Peroxidation; Liver; Lysosomes; Male; Methylamines; Monensin; Oxidation-Reduction; Pepstatins; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2001 |
A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.
Topics: Adenine; Autophagy; Cytoplasmic Vesicles; DNA, Neoplasm; Dose-Response Relationship, Radiation; Humans; Hydrogen-Ion Concentration; Microscopy, Electron; Proton-Translocating ATPases; Time Factors; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases | 2001 |
The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction.
Topics: Adenine; Aging; Amino Acids; Animals; Autophagy; Cycloheximide; Diet; Food Deprivation; Hepatocytes; Liver; Male; Rats; Rats, Sprague-Dawley | 2001 |
Evidence in Escherichia coli that N3-methyladenine lesions induced by a minor groove binding methyl sulfonate ester can be processed by both base and nucleotide excision repair.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Adenine; Adenosine Triphosphatases; Alkylating Agents; Bacterial Proteins; Binding Sites; Cisplatin; DNA Damage; DNA Repair; DNA-Binding Proteins; Escherichia coli; Escherichia coli Proteins; Methyl Methanesulfonate; Netropsin; Nucleic Acid Heteroduplexes; Thermodynamics | 2001 |
Liver alcohol dehydrogenase is degraded by the ubiquitin-proteasome pathway.
Topics: Acetylcysteine; Adenine; Alcohol Dehydrogenase; Animals; Calpain; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dihydrotestosterone; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leupeptins; Liver; Lysosomes; Male; Multienzyme Complexes; Precipitin Tests; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Ubiquitins | 2001 |
Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29.
Topics: Adenine; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Autophagy; Caspases; Colonic Neoplasms; Cyclooxygenase 2; Cytochrome c Group; Dose-Response Relationship, Drug; Drug Antagonism; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sulindac; Tumor Cells, Cultured | 2001 |
Cell-cell adhesion-independent killing due to lymphokine-activated killer cells against glioblastoma cell lines.
Topics: Acid Phosphatase; Adenine; Apoptosis; Cell Adhesion; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Glioblastoma; Humans; Killer Cells, Lymphokine-Activated; Lysosomes; Microscopy, Electron; Time Factors; Tumor Cells, Cultured | 2000 |
A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation.
Topics: Adenine; Amino Acids; Androstadienes; Animals; Autophagy; Cadaverine; CHO Cells; Cricetinae; Cycloheximide; Enzyme Inhibitors; Ethylmaleimide; Fluorescent Dyes; Phagosomes; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Vacuoles; Vinblastine; Wortmannin | 2001 |
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.
Topics: Adenine; Animals; Arabinofuranosylcytosine Triphosphate; Cytarabine; Cytochrome c Group; Drug Interactions; Enzyme Inhibitors; Ion Channels; Kinetin; Male; Mitochondria, Heart; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nucleic Acid Synthesis Inhibitors; Purines; Rats; Rats, Wistar | 2002 |
Fractionation analysis of the endosomal compartment during rat reticulocyte maturation.
Topics: Adenine; Animals; Autophagy; Blotting, Western; Cell Compartmentation; Cell Differentiation; Cell Fractionation; Endosomes; Extracellular Space; HSP70 Heat-Shock Proteins; Microscopy, Electron; rab5 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Receptors, Transferrin; Reticulocytes; Secretory Vesicles; Subcellular Fractions | 2002 |
Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
Topics: Adenine; Alkylation; Amino Acid Sequence; Archaeoglobus fulgidus; Cell Fractionation; Cloning, Molecular; DNA Glycosylases; DNA Methylation; DNA Repair; Enzyme Inhibitors; Enzyme Repression; Escherichia coli Proteins; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Mutation; N-Glycosyl Hydrolases; Phylogeny; Sequence Homology, Amino Acid; Substrate Specificity | 2002 |
Acidity of adenine and adenine derivatives and biological implications. A computational and experimental gas-phase study.
Topics: Adenine; Alkylation; Catalysis; Computational Biology; DNA; Hydrogen-Ion Concentration; Models, Molecular; Spectroscopy, Fourier Transform Infrared; Stereoisomerism | 2002 |
Inhibition of autophagy in mitotic animal cells.
Topics: Adenine; Anaphase; Androstadienes; Animals; Autophagy; Blotting, Western; Cell Line; Chromones; Endoplasmic Reticulum; Enzyme Inhibitors; Golgi Apparatus; HeLa Cells; Humans; Immunohistochemistry; Metaphase; Microscopy, Immunoelectron; Microscopy, Phase-Contrast; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Telophase; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2002 |
Base excision repair and nucleotide excision repair contribute to the removal of N-methylpurines from active genes.
Topics: Adenine; Animals; Cells, Cultured; DNA Damage; DNA Glycosylases; DNA Repair; DNA Replication; Guanine; Mice; Mice, Knockout; N-Glycosyl Hydrolases; Phenotype; Pyrimidine Dimers; Tetrahydrofolate Dehydrogenase; Transcription, Genetic | 2002 |
Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability.
Topics: Adenine; Amino Acids; Animals; Anisomycin; Blotting, Western; Carrier Proteins; CHO Cells; Cricetinae; Cycloheximide; Enzyme Inhibitors; Gene Expression Regulation; Immunosuppressive Agents; Insulin; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Initiation Factors; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Synthesis Inhibitors; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2003 |
Neuregulin promotes autophagic cell death of prostate cancer cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Autophagy; Cell Death; Cell Division; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Ligands; Male; Morpholines; Neuregulins; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine | 2003 |
Endostatin induces autophagic cell death in EAhy926 human endothelial cells.
Topics: Acridine Orange; Adenine; Animals; Antineoplastic Agents; Apoptosis; Aprotinin; Blotting, Western; Caspases; Cell Death; Cells, Cultured; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Endostatins; Endothelial Cells; Endothelium, Vascular; Enzyme Activation; Flow Cytometry; Glutathione Transferase; Humans; Immunohistochemistry; Leupeptins; Lysosomes; Microscopy, Electron; Microscopy, Phase-Contrast; Oxidative Stress; Reactive Oxygen Species; Recombinant Proteins; Serine; Time Factors | 2003 |
Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis.
Topics: Adenine; Animals; Autophagy; Cell Survival; Cellular Senescence; Cytochromes c; DNA, Mitochondrial; Electron Transport Complex IV; Immunohistochemistry; Lysosomes; Microscopy, Electron; Mitochondria, Heart; Myocytes, Cardiac; Oxidative Stress; Rats | 2003 |
Solution structure and base perturbation studies reveal a novel mode of alkylated base recognition by 3-methyladenine DNA glycosylase I.
Topics: Adenine; Alkylation; Binding Sites; Carboxylic Acids; Catalysis; Cations; DNA Glycosylases; DNA Repair; Hydrogen Bonding; Hydrogen-Ion Concentration; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Mutagenesis; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Spectrometry, Fluorescence; Temperature; Thermodynamics | 2003 |
The enzymic conversion of adenine to 3-methyladenine.
Topics: Adenine; Transferases | 1962 |
DNA damage and cytotoxicity induced by minor groove binding methyl sulfonate esters.
Topics: Adenine; Anti-Bacterial Agents; Base Sequence; DNA Adducts; DNA Damage; DNA Fragmentation; DNA Methylation; DNA Repair; DNA, Bacterial; Escherichia coli; Esters; Guanine; Mesylates; Molecular Sequence Data; Netropsin; Nucleic Acid Conformation; Protein Binding | 2003 |
Coronavirus replication complex formation utilizes components of cellular autophagy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 12; Blotting, Western; Cell Division; Cell Line; Coronavirus; Cytoplasm; Embryo, Mammalian; Endoplasmic Reticulum, Rough; Mice; Microscopy, Electron; Microscopy, Fluorescence; Microtubule-Associated Proteins; Phylogeny; Protein Binding; Protein Transport; Proteins; Saccharomyces cerevisiae Proteins; Stem Cells; Time Factors | 2004 |
Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.
Topics: Adenine; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Survival; Dacarbazine; Dose-Response Relationship, Drug; Glioma; Humans; Macrolides; Microtubule-Associated Proteins; Organelles; Temozolomide | 2004 |
Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration.
Topics: Adenine; Adenosine Triphosphate; Animals; Biological Transport, Active; Cells, Cultured; Dose-Response Relationship, Drug; Eye Proteins; Humans; Hydrogen-Ion Concentration; Hydrolases; Lipofuscin; Lysosomes; Macular Degeneration; Phagocytosis; Pigment Epithelium of Eye; Proton Pump Inhibitors; Retinoids; Rod Cell Outer Segment; Swine | 2004 |
Growth factor deprivation induces an alternative non-apoptotic death mechanism that is inhibited by Bcl2 in cells derived from neural precursor cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase Inhibitors; Cell Death; Cell Differentiation; Cell Survival; Chromones; Cycloheximide; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immunohistochemistry; Intermediate Filament Proteins; Luminescent Proteins; Mesencephalon; Mice; Microscopy, Electron; Morpholines; Nerve Tissue Proteins; Nestin; Neurons; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Stem Cells; Transformation, Genetic; Tubulin; Vacuoles | 2003 |
3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.
Topics: Adenine; Androstadienes; Animals; Biological Transport; Cations; Cell Line; Chromones; Endosomes; Enzyme Inhibitors; Liver; Lysosomes; Mannosephosphates; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Rats; Receptor, IGF Type 2; Subcellular Fractions; Time Factors; trans-Golgi Network; Transferrin; Wortmannin | 2004 |
3-methyladenine inhibits autophagy in tobacco culture cells under sucrose starvation conditions.
Topics: Adenine; Androstadienes; Autophagy; Cell Death; Cells, Cultured; Endopeptidases; Enzyme Inhibitors; Lysosomes; Microscopy, Electron; Nicotiana; Phosphoinositide-3 Kinase Inhibitors; Plant Proteins; Sucrose; Vacuoles; Wortmannin | 2004 |
Nucleotide excision repair defect influences lethality and mutagenicity induced by Me-lex, a sequence-selective N3-adenine methylating agent in the absence of base excision repair.
Topics: Adenine; Base Sequence; DNA Methylation; DNA Mutational Analysis; DNA Repair; DNA Repair Enzymes; Gene Deletion; Gene Silencing; Humans; Mutagenesis; Mutagens; Netropsin; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tumor Suppressor Protein p53 | 2004 |
Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death.
Topics: Acetaldehyde; Adenine; Alkylating Agents; Animals; Apoptosis; Astrocytes; Cell Culture Techniques; Cerebellum; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Female; Glutathione; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagens; Netropsin; Neurons; Oxidation-Reduction; Xeroderma Pigmentosum Group A Protein | 2004 |
The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.
Topics: Adenine; Animals; Animals, Newborn; Antibodies; Autophagy; Cell Death; Cell Survival; Cells, Cultured; Cerebellum; Lysosomes; Nerve Growth Factor; Neurodegenerative Diseases; Neuroprotective Agents; Protein Structure, Tertiary; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptors, Nerve Growth Factor; Vacuoles | 2004 |
Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells.
Topics: Adenine; Apoptosis; Autophagy; Brain Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Enzyme Inhibitors; Glioma; Hot Temperature; Humans; Macrolides; Organelles; Thermodynamics | 2004 |
Aging of cardiac myocytes in culture: oxidative stress, lipofuscin accumulation, and mitochondrial turnover.
Topics: Adenine; Aging; Animals; Animals, Newborn; Cells, Cultured; Image Processing, Computer-Assisted; Lipofuscin; Lysosomes; Mitochondria; Myocytes, Cardiac; Oxidative Stress; Rats; Reactive Oxygen Species; Time Factors | 2004 |
Interaction of Chlamydia trachomatis serovar L2 with the host autophagic pathway.
Topics: Adenine; Amino Acids; Autophagy; Cadaverine; Calreticulin; Cell Line; Chlamydia trachomatis; Fluorescent Dyes; Humans; Inclusion Bodies; Microscopy, Confocal; Microscopy, Electron; Microtubule-Associated Proteins; Phagosomes; Serotyping | 2004 |
N3-methyladenine induces early poly(ADP-ribosylation), reduction of nuclear factor-kappa B DNA binding ability, and nuclear up-regulation of telomerase activity.
Topics: Adenine; Cell Line, Tumor; Cell Nucleus; DNA; Enzyme Activation; Humans; NF-kappa B; Poly Adenosine Diphosphate Ribose; Protein Binding; Telomerase; Up-Regulation | 2005 |
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Beclin-1; Cells, Cultured; Etoposide; Fibroblasts; Humans; Lysosomes; Membrane Proteins; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Nucleic Acid Synthesis Inhibitors; Proteins; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Saccharomyces cerevisiae Proteins; Ubiquitin-Protein Ligases | 2004 |
Effects of substrate specificity on initiating the base excision repair of N-methylpurines by variant human 3-methyladenine DNA glycosylases.
Topics: Adenine; Animals; DNA Damage; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Genetic Engineering; Guanine; Humans; Methyl Methanesulfonate; Mutagens; Saccharomyces cerevisiae; Substrate Specificity | 2005 |
Inhibition of macroautophagy triggers apoptosis.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Caspase Inhibitors; Caspases; Cells, Cultured; Enzyme Inhibitors; HeLa Cells; Humans; Immediate-Early Proteins; Lysosomes; Mice; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mitochondria; Monensin; Phagosomes; Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Viral Proteins | 2005 |
Inhibition of autophagy with 3-methyladenine results in impaired turnover of lysosomes and accumulation of lipofuscin-like material.
Topics: Adenine; Autophagy; Cathepsins; Cells, Cultured; Fibroblasts; Humans; Hyperoxia; Lipofuscin; Lysosomes; Mitochondria; Procollagen; Time Factors | 2004 |
Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Antigens, CD; Apoptosis; Autophagy; Caspases; Cathepsins; Cell Size; Cell Survival; Cells, Cultured; Cerebellum; Colforsin; Coumarins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Interactions; Erythroid-Specific DNA-Binding Factors; Extracellular Signal-Regulated MAP Kinases; Fluorescent Antibody Technique; Gene Expression Regulation; Glycoside Hydrolases; Green Fluorescent Proteins; Lysosomal Membrane Proteins; Lysosomes; Microscopy, Electron; Microtubule Proteins; Neurons; Oligopeptides; Potassium; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Teprotide; Time Factors; Transcription Factors | 2005 |
Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Amino Acid Chloromethyl Ketones; Autophagy; Autophagy-Related Protein 5; Binding Sites; Cell Death; Cell Line; Fas-Associated Death Domain Protein; Gene Deletion; Gene Expression; HeLa Cells; Humans; Interferon-gamma; Microtubule-Associated Proteins; Mutagenesis; Oligonucleotides, Antisense; Saccharomyces cerevisiae; Transfection; Two-Hybrid System Techniques; Vacuoles | 2005 |
The role of acidic organelles in the development of schistosomula of Schistosoma mansoni and their response to signalling molecules.
Topics: Adenine; Androstadienes; Animals; Energy Metabolism; Ethylmaleimide; Helminth Proteins; Life Cycle Stages; Organelles; Schistosoma mansoni; Staining and Labeling; Wortmannin | 2005 |
Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells.
Topics: Adenine; Apoptosis; Autophagy; Brain Neoplasms; Cell Cycle; DNA Damage; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Humans; Macrolides; Microtubule-Associated Proteins; Radiation Tolerance | 2005 |
Testing the "garbage" accumulation theory of ageing: mitotic activity protects cells from death induced by inhibition of autophagy.
Topics: Adenine; Aging; Astrocytes; Autophagy; Cell Line; Cell Survival; Cellular Senescence; Cysteine Proteinase Inhibitors; Fibroblasts; Humans; Leupeptins; Mitosis; Phosphoinositide-3 Kinase Inhibitors | 2005 |
The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies.
Topics: Adenine; Androstenes; Animals; Autophagy; Biological Transport; Cell Line; Cell Membrane; Cells, Cultured; Cholesterol; Culture Media, Serum-Free; Endocytosis; Epithelial Cells; Glycosylation; Lipid Metabolism; Lysosomes; Microscopy, Electron; Microscopy, Fluorescence; Mink; Models, Biological; Phagocytosis; Phagosomes; Phosphatidylinositol 3-Kinases; Phospholipids; Pulmonary Alveoli; Surface-Active Agents; Time Factors; Transfection; Vacuoles | 2005 |
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.
Topics: Adenine; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Breast Neoplasms; Cadaverine; Calcitriol; Cathepsins; Cell Death; Cell Growth Processes; Cell Line, Tumor; Cryoelectron Microscopy; Drug Interactions; Genes, Tumor Suppressor; HeLa Cells; Humans; Immunoblotting; Membrane Proteins; Proteins; RNA, Small Interfering; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2005 |
DNA methylation, cell proliferation, and histopathology in rats following repeated inhalation exposure to dimethyl sulfate.
Topics: Adenine; Administration, Inhalation; Alkylating Agents; Animals; Body Weight; Cell Proliferation; DNA; DNA Adducts; DNA Methylation; Guanine; Male; Methylation; Models, Biological; Mutagens; Olfactory Mucosa; Purines; Rats; Risk; Sulfuric Acid Esters | 2004 |
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Ceramides; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Humans; Hydrolysis; Lactosylceramides; Membrane Proteins; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; RNA Interference; RNA, Small Interfering; Starvation; TOR Serine-Threonine Kinases; Ubiquitin-Activating Enzymes | 2006 |
Autophagy is not a main contributor to the degradation of phospholipids in tobacco cells cultured under sucrose starvation conditions.
Topics: Adenine; Autophagy; Cells, Cultured; Chromatography, Thin Layer; Glycerol; Nicotiana; Oxidative Phosphorylation; Phosphatidylcholines; Phospholipids; Phosphorylcholine; Sucrose; Time Factors | 2006 |
Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing.
Topics: Adenine; Animals; Cell Line; CHO Cells; Cricetinae; Cricetulus; Dextrans; Endocytosis; Fibroblasts; Fluorescein-5-isothiocyanate; Humans; Infant; Lipoproteins, LDL; Macrolides; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Ceroid-Lipofuscinoses; Saponins; Saposins; Serum Albumin, Bovine; Thiolester Hydrolases; Transferrin | 2006 |
Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Ammonium Chloride; Apoptosis; Autophagy; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Crotoxin; Cytochromes c; Enzyme Activation; Humans; K562 Cells; Lysosomes; Mitochondria; Oligopeptides; Vacuoles | 2006 |
Survival of parvovirus B19-infected cells by cellular autophagy.
Topics: Adenine; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Survival; Cytoplasm; Enzyme Inhibitors; Erythroid Cells; Flow Cytometry; Humans; Microscopy, Fluorescence; Microtubule-Associated Proteins; Parvovirus B19, Human; Phagosomes; Viral Nonstructural Proteins | 2006 |
ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Caspase 12; Cell Death; eIF-2 Kinase; Endoplasmic Reticulum; Enzyme Activation; Eukaryotic Initiation Factor-2; Gene Expression Regulation; Leucine; Lysosomes; Mice; Microtubule-Associated Proteins; Models, Biological; Pepstatins; Peptides; Phosphorylation; Protein Structure, Quaternary; RNA, Messenger; Sirolimus | 2007 |
Increased resistance of lipofuscin-loaded prematurely senescent fibroblasts to starvation-induced programmed cell death.
Topics: Adenine; Apoptosis; Autophagy; Caspase 3; Cathepsin D; Cell Line; Cell Survival; Cellular Senescence; Culture Media, Serum-Free; Humans; Lipofuscin; Lysosomes | 2007 |
Augmentation of oridonin-induced apoptosis observed with reduced autophagy.
Topics: Adenine; Androstadienes; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; bcl-2-Associated X Protein; Cell Proliferation; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; HeLa Cells; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Sirtuin 1; Sirtuins; Time Factors; Wortmannin | 2006 |
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Characterization of nucleobase-amino acid stacking interactions utilized by a DNA repair enzyme.
Topics: Adenine; Amino Acids; Binding Sites; Biophysics; Chemistry, Physical; Crystallization; DNA; DNA Repair; Models, Chemical; Models, Molecular; Molecular Conformation; Nucleic Acid Conformation; Nucleotides; Thermodynamics | 2006 |
Mitochondrial aberrations in mucolipidosis Type IV.
Topics: Adenine; Autophagy; Biological Transport; Calcium; Caspase 8; DNA Fragmentation; Fibroblasts; Homozygote; Humans; Ions; Lysosomes; Mitochondria; Mucolipidoses; Phagocytosis; Transient Receptor Potential Channels; TRPM Cation Channels | 2006 |
AtATG genes, homologs of yeast autophagy genes, are involved in constitutive autophagy in Arabidopsis root tip cells.
Topics: Adenine; Aminopeptidases; Arabidopsis; Arabidopsis Proteins; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Proteins; Gene Expression Regulation, Plant; Genes, Plant; Meristem; Mutation; Phosphoric Monoester Hydrolases; Sucrose; Vacuoles | 2006 |
Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells.
Topics: Adenine; Androstadienes; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Membrane Fusion; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Pinocytosis; Vesicular Transport Proteins; Wortmannin | 2006 |
DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
Topics: Adenine; Amino Acid Sequence; Bacterial Proteins; Binding Sites; DNA Damage; DNA Glycosylases; DNA Repair; DNA, Bacterial; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Structure, Tertiary; Recombinant Fusion Proteins; Salmonella typhi | 2007 |
Characterization of the physiological turnover of native and inactivated cytochromes P450 3A in cultured rat hepatocytes: a role for the cytosolic AAA ATPase p97?
Topics: Adenine; Adenosine Triphosphatases; Ammonium Chloride; Animals; Autophagy; Boronic Acids; Cell Cycle Proteins; Cross-Linking Reagents; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Dicarbethoxydihydrocollidine; Formaldehyde; Hepatocytes; Leupeptins; Lysosomes; Male; Nuclear Proteins; Polymers; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Saccharomyces cerevisiae Proteins; Troleandomycin; Ubiquitin; Valosin Containing Protein | 2007 |
3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition.
Topics: Actins; Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Survival; Chromones; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors | 2007 |
Induction of autophagy does not affect human rhinovirus type 2 production.
Topics: Adenine; Autophagy; Cells, Cultured; Humans; Microtubule-Associated Proteins; Phagosomes; Rhinovirus; Sirolimus; Tamoxifen; Virus Replication | 2007 |
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Bone Marrow Cells; Calcium-Binding Proteins; CARD Signaling Adaptor Proteins; Caspase 1; Cells, Cultured; Cytoskeletal Proteins; Gene Expression Regulation, Enzymologic; Gene Silencing; Interleukin-1beta; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Shigella flexneri | 2007 |
A role for yeast and human translesion synthesis DNA polymerases in promoting replication through 3-methyl adenine.
Topics: Adenine; Adenosine Triphosphatases; Antineoplastic Agents, Alkylating; Binding Sites; DNA Helicases; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Evolution, Molecular; Humans; Isoenzymes; Ligases; Methyl Methanesulfonate; Models, Molecular; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases | 2007 |
Caspase-independent autophagic cytotoxicity in etoposide-treated CaSki cervical carcinoma cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase Inhibitors; Caspases; Cell Line, Tumor; Etoposide; Female; Humans; Macrolides; Membrane Proteins; Uterine Cervical Neoplasms | 2007 |
Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
Topics: Adenine; Androstadienes; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; bcl-X Protein; Beclin-1; Cell Line, Tumor; Cell Proliferation; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Flow Cytometry; Humans; Indoles; Membrane Potential, Mitochondrial; Membrane Proteins; Microtubule-Associated Proteins; Molecular Structure; Phenols; Phosphatidylethanolamines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-raf; ras Proteins; Wortmannin | 2007 |
Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells.
Topics: 2-Methoxyestradiol; Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Astrocytes; Autophagy; Cell Line, Transformed; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Estradiol; HeLa Cells; Humans; Hydrogen Peroxide; Mice; Oxidants; Oxidative Stress; Reactive Oxygen Species; RNA, Small Interfering; Tubulin Modulators | 2008 |
Apoptosis and autophagy as mechanisms of dinoflagellate symbiont release during cnidarian bleaching: every which way you lose.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Androstadienes; Animals; Apoptosis; Autophagy; Dinoflagellida; Dose-Response Relationship, Drug; Hot Temperature; RNA Interference; Sea Anemones; Sirolimus; Symbiosis; Wortmannin | 2007 |
The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; HeLa Cells; Humans; Membrane Proteins; Mice; Microtubule-Associated Proteins; Neoplasms; Neurodegenerative Diseases; NIH 3T3 Cells; Pancreatitis, Acute Necrotizing; Phagosomes; Protein Binding; Proteins; RNA, Small Interfering; Sirolimus | 2007 |
Subversion of cellular autophagy by Anaplasma phagocytophilum.
Topics: Adenine; Anaplasma phagocytophilum; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line; Haplorhini; Humans; Inclusion Bodies; Intracellular Membranes; Lipid Bilayers; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Sirolimus | 2008 |
Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cells, Cultured; Gene Expression Regulation; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nerve Degeneration; Nerve Growth Factor; Neurites; Neurons; Neuroprotective Agents; Proteins; Rats; RNA Interference; Superior Cervical Ganglion; Time Factors; Transfection | 2007 |
Stimulation of mitochondrial biogenesis and autophagy by lipopolysaccharide in the neonatal rat cardiomyocyte protects against programmed cell death.
Topics: Adenine; Adenosine Triphosphate; Animals; Animals, Newborn; Apoptosis; Autophagy; Biomarkers; Blotting, Western; Caspase 3; Cells, Cultured; Glutathione; Ion Channels; L-Lactate Dehydrogenase; Lipopolysaccharides; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Myocytes, Cardiac; Oxidative Stress; Poly(ADP-ribose) Polymerases; Rats; Reactive Oxygen Species; Transcription Factors; Uncoupling Protein 3 | 2008 |
Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.
Topics: Adenine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagy; Brain; Cell Line, Tumor; Disease Models, Animal; Endopeptidases; Humans; Hypoxia, Brain; Membrane Proteins; Mice; Mice, Transgenic; Peptide Hydrolases; Plaque, Amyloid; Presenilin-1 | 2009 |
Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation.
Topics: Adenine; Anthracenes; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cadaverine; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; HeLa Cells; Humans; Imidazoles; Isodon; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Polyenes; Polyunsaturated Alkamides; Pyridines; ras Proteins | 2007 |
An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid.
Topics: Adenine; Animals; Apoptosis; Autophagy; Corpus Striatum; DNA Fragmentation; Gene Expression Regulation; Kainic Acid; Lysosomal-Associated Membrane Protein 2; Lysosomes; Microtubule-Associated Proteins; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 2008 |
Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells.
Topics: Adenine; Ammonium Chloride; Arsenic Trioxide; Arsenicals; Autophagy; Cadaverine; Cell Death; Fluorescent Antibody Technique; HL-60 Cells; Humans; Mitochondrial Membranes; Oxides; Subcellular Fractions | 2008 |
Characterization of Rab21-positive tubular endosomes induced by PI3K inhibitors.
Topics: Adenine; Androstadienes; Cell Line, Tumor; Endosomes; Enzyme Inhibitors; Humans; Microscopy, Fluorescence; Microtubules; Phosphoinositide-3 Kinase Inhibitors; rab GTP-Binding Proteins; Wortmannin | 2008 |
Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.
Topics: Adenine; Antimutagenic Agents; Cell Survival; DNA Glycosylases; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Directed DNA Polymerase; Endodeoxyribonucleases; Mutagens; Netropsin; Nucleotidyltransferases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tumor Suppressor Protein p53 | 2008 |
Enhanced autophagy and mitochondrial aberrations in murine G(M1)-gangliosidosis.
Topics: Adenine; Adenosine Triphosphate; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; beta-Galactosidase; Brain; Cells, Cultured; Disease Models, Animal; Electron Transport Complex IV; Enzyme Inhibitors; G(M1) Ganglioside; Gangliosidosis, GM1; Lysosomes; Mice; Mice, Knockout; Microtubule-Associated Proteins; Mitochondria; Paraquat; Protein Kinases; Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2008 |
A novel cell death pathway that is partially caspase dependent, but morphologically non-apoptotic, elicited by proteasomal inhibition of rat sympathetic neurons.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Bcl-2-Like Protein 11; bcl-X Protein; Caspases; Cell Death; Cell Shape; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Ganglia, Sympathetic; Membrane Proteins; Mice; Mice, Inbred C57BL; Neurons; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Rats, Wistar; Signal Transduction; Species Specificity | 2008 |
DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing.
Topics: Actins; Adenine; Amino Acid Motifs; Apoptosis Regulatory Proteins; Autophagy; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Cell Membrane; Death-Associated Protein Kinases; Humans; Microtubule-Associated Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Peptide Library; Peptides; Protein Binding; Signal Transduction; Tubulin | 2008 |
Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carrier Proteins; Cell Differentiation; Cell Line, Tumor; Cell Size; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Mice; Morpholines; Neurites; Neuroblastoma; Neurons; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tretinoin | 2008 |
A method to measure cardiac autophagic flux in vivo.
Topics: Adenine; Animals; Antirheumatic Agents; Autophagy; Cadaverine; Cell Line; Chloroquine; Green Fluorescent Proteins; Macrolides; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Myocytes, Cardiac; Phagosomes; Proton-Translocating ATPases; Recombinant Fusion Proteins | 2008 |
Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Caspases; Cell Line; Cisplatin; Epithelial Cells; Kidney Tubules; LLC-PK1 Cells; Swine | 2008 |
Glioma regression in vitro and in vivo by a suicide combined treatment.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Adenine; Animals; Brain Neoplasms; Cell Death; Dogs; Drug Therapy, Combination; Glioma; Glucose Oxidase; Hydrogen Peroxide; Nitriles | 2008 |
The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium.
Topics: Adenine; Adenosine Triphosphate; Animals; Annexin A5; Apoptosis; Autophagy; Chick Embryo; In Situ Nick-End Labeling; Microscopy, Electron, Transmission; Phagocytosis; Phosphatidylserines; Retina; Retinal Ganglion Cells | 2008 |
Monitoring of dimethyl sulphate-induced N3-methyladenine, N7-methylguanine and O(6)-methylguanine DNA adducts using reversed-phase high performance liquid chromatography and mass spectrometry.
Topics: Adenine; Animals; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Male; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfuric Acid Esters; Testis | 2008 |
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzothiazoles; Cell Line; Cisplatin; Genes, bcl-2; Humans; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Proteins; Rats; RNA, Small Interfering; Toluene; Transfection; Tumor Suppressor Protein p53 | 2008 |
The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; Humans; Membrane Proteins; Molecular Chaperones; Phagosomes; Phosphatidylinositol 3-Kinases; Protein Folding; RNA Interference; Signal Transduction | 2008 |
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Biomarkers; Brain; Brain Ischemia; Cathepsin B; Cysteine Proteinase Inhibitors; Humans; Infarction, Middle Cerebral Artery; Lysosomes; Male; Neurons; Neuroprotective Agents; Phagosomes; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction | 2008 |
Autophagosome supports coxsackievirus B3 replication in host cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cell Line; Enterovirus B, Human; HeLa Cells; Humans; Lysosomes; Membrane Proteins; Phagosomes; RNA, Small Interfering; Ubiquitin-Activating Enzymes; Virus Replication | 2008 |
Multiple cyclin kinase inhibitors promote bile acid-induced apoptosis and autophagy in primary hepatocytes via p53-CD95-dependent signaling.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Bile; Cells, Cultured; Cholagogues and Choleretics; Cyclin-Dependent Kinase Inhibitor Proteins; Deoxycholic Acid; eIF-2 Kinase; Endoplasmic Reticulum Chaperone BiP; fas Receptor; Gene Expression; Hepatocytes; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mice, Knockout; Microtubule-Associated Proteins; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease.
Topics: Adenine; Alzheimer Disease; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Enzyme Inhibitors; Immunohistochemistry; Lysosomes; Microscopy, Electron, Transmission; Neurons; Neuroprotective Agents; Okadaic Acid; Phagosomes; Protein Kinases; Rats; TOR Serine-Threonine Kinases | 2008 |
Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blood Pressure; Disease Models, Animal; Doxorubicin; Gene Expression; Heart Failure; Heart Rate; Male; Membrane Potential, Mitochondrial; Mitochondria; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2009 |
Induction of autophagy by proteasome inhibitor is associated with proliferative arrest in colon cancer cells.
Topics: Adenine; Autophagy; Cell Division; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Cytoplasmic Vesicles; G2 Phase; Humans; Leupeptins; Microtubule-Associated Proteins; Proteasome Inhibitors; Vacuoles | 2008 |
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Membrane; Chloroquine; Culture Media; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Humans; Hypoxia; Lysosomes; Macrolides; Neuropilin-1; Neuropilin-2; Sirolimus | 2008 |
Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Cell Shape; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glucose; Leupeptins; Male; Microtubule-Associated Proteins; Myocytes, Cardiac; Necrosis; Rats; Rats, Sprague-Dawley; RNA Interference; RNA, Small Interfering; Sirolimus; Time Factors; Vacuoles | 2008 |
[Effect of starvation-induced autophagy on cell cycle of tumor cells].
Topics: Adenine; Autophagy; Cell Cycle; Cyclin A; Cyclin B1; Cyclin D3; Cyclin E; Cyclins; Down-Regulation; HeLa Cells; Humans; Hydrolysis; Microtubule-Associated Proteins | 2008 |
Autophagy is activated, but is not required for the G0 function of BCL-2 or BCL-xL.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; bcl-X Protein; Cell Size; CHO Cells; Cricetinae; Cricetulus; Cyclin-Dependent Kinase Inhibitor p27; Fibroblasts; Humans; Mice; Microtubule-Associated Proteins; NIH 3T3 Cells; Resting Phase, Cell Cycle; RNA; Up-Regulation | 2008 |
Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury.
Topics: Adenine; Analysis of Variance; Androstadienes; Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Count; Cerebral Cortex; Hippocampus; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Necrosis; Neurons; Rats; Rats, Sprague-Dawley; Simvastatin; Sirolimus; Wortmannin | 2008 |
Coxsackievirus B4 uses autophagy for replication after calpain activation in rat primary neurons.
Topics: Adenine; Animals; Apoptosis; Autophagy; Calpain; Cells, Cultured; Cerebral Cortex; Enterovirus B, Human; Neurons; Rats; Virus Replication | 2008 |
Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner.
Topics: Adenine; Amitrole; Apoptosis; Autophagy; Autophagy-Related Protein 5; Capsaicin; Caspase 3; Catalase; Cell Line, Tumor; Enzyme Inhibitors; Humans; Microtubule-Associated Proteins; Neoplasms; Reactive Oxygen Species; RNA, Small Interfering | 2008 |
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Carrier Proteins; Chimera; Colitis; Dextran Sulfate; Female; Gene Expression Regulation; Interleukin-1beta; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Mutation | 2008 |
Induction of autophagic cell death by a novel molecule is increased by hypoxia.
Topics: Adenine; Amidines; Androstadienes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neoplasms; Phagosomes; Thiourea; Trifluoperazine; Vascular Endothelial Growth Factor A; Wortmannin | 2008 |
Consequences of the DYT1 mutation on torsinA oligomerization and degradation.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chlorocebus aethiops; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Molecular Chaperones; Mutation; Oligopeptides; Time Factors; Transfection | 2008 |
Caspase-independent type III PCD: a new means to modulate cell death in chronic lymphocytic leukemia.
Topics: Adenine; Caspases; CD47 Antigen; Cell Death; Dynamins; GTP Phosphohydrolases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Microtubule-Associated Proteins; Mitochondrial Proteins | 2009 |
OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazoles; Reactive Oxygen Species; Sulfonamides; Xenograft Model Antitumor Assays | 2008 |
Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation.
Topics: Adenine; Animals; Autophagy; Carrier Proteins; Cells, Cultured; Culture Media, Conditioned; Insulin; Mice; Neurons; Phosphotransferases (Alcohol Group Acceptor); Polyglutamic Acid; Receptors, Androgen; Signal Transduction; Stress, Physiological; Tissue Culture Techniques; TOR Serine-Threonine Kinases | 2009 |
LC3-I conversion to LC3-II does not necessarily result in complete autophagy.
Topics: Adenine; Autophagy; Blotting, Western; Dopamine; Humans; Microscopy, Electron; Microscopy, Fluorescence; Microtubule-Associated Proteins; Neuroblastoma; Phosphatidylinositol 3-Kinases; Protein Kinases; Serum; Sirolimus; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2008 |
Induction of autophagic cell death and radiosensitization by the pharmacological inhibition of nuclear factor-kappa B activation in human glioma cell lines.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Enzyme Inhibitors; Glioma; Humans; Immunoblotting; NF-kappa B; Quinolines; Radiation Tolerance | 2009 |
Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Benzamides; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cisplatin; Extracellular Signal-Regulated MAP Kinases; Glioma; Humans; Imatinib Mesylate; Macrolides; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Paclitaxel; Piperazines; Pyrimidines | 2009 |
The autophagic induction in Helicobacter pylori-infected macrophage.
Topics: Adenine; Animals; Autophagy; Bacterial Proteins; Cell Line; Cell Proliferation; Helicobacter Infections; Helicobacter pylori; Humans; Macrophages; Mice; Microbial Viability; Microtubule-Associated Proteins; Monocytes; Mutation; Sirolimus; Vacuoles | 2009 |
Autophagy is involved in influenza A virus replication.
Topics: Adenine; Androstadienes; Animals; Autophagy; Cell Survival; Dogs; Humans; Influenza A virus; Microscopy, Fluorescence; Microtubule-Associated Proteins; Microtubules; Models, Biological; RNA; RNA Interference; RNA, Small Interfering; Virus Replication; Wortmannin | 2009 |
Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Autophagy-Related Protein 12; Chlorocebus aethiops; COS Cells; Cytosol; HeLa Cells; Humans; Lysosomes; Membrane Fusion; Neurodegenerative Diseases; Peroxisomes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Sequestosome-1 Protein; Small Ubiquitin-Related Modifier Proteins; Ubiquitin; Ubiquitination | 2008 |
Induction of autophagy by anthrax lethal toxin.
Topics: Acridine Orange; Adenine; Animals; Antigens, Bacterial; Autophagy; Bacterial Toxins; Cell Line; Cytosol; Green Fluorescent Proteins; Mice; Microtubule-Associated Proteins; Vacuoles | 2009 |
Autophagy is involved in the ischemic preconditioning.
Topics: Adenine; Animals; Autophagy; Cathepsin D; Cell Survival; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Immunohistochemistry; Ischemic Preconditioning; Lysosomes; Microscopy, Electron, Transmission; Nerve Degeneration; Neurons; PC12 Cells; Phagosomes; Rats; Reperfusion Injury; Tetrazolium Salts | 2009 |
Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cytochromes c; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Humans | 2009 |
Autophagy in coxsackievirus-infected neurons.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autophagy; Calpain; Caspases; Coxsackievirus Infections; Cysteine Proteinase Inhibitors; Models, Biological; Neurons; Rats; Sirolimus; Virus Replication | 2009 |
Homologs of genes associated with programmed cell death in animal cells are differentially expressed during senescence of Ipomoea nil petals.
Topics: Adenine; Amino Acid Sequence; Autophagy; DNA Fragmentation; Ethylenes; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Ipomoea; Molecular Sequence Data; Plant Proteins; RNA, Plant; Sequence Alignment | 2009 |
A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; bcl-X Protein; Dose-Response Relationship, Drug; Green Fluorescent Proteins; HeLa Cells; Humans; Indoles; Microscopy, Electron, Transmission; Models, Chemical; Molecular Conformation; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Surface Plasmon Resonance | 2009 |
Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells.
Topics: Adenine; Autophagy; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Humans; Microtubule-Associated Proteins; Pyrazoles; Vacuoles | 2009 |
p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Benzothiazoles; Cell Death; Corpus Striatum; Enzyme Inhibitors; Humans; Macrolides; Membrane Proteins; Neurons; Neurotoxins; Nitro Compounds; Propionates; Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Toluene; Tumor Suppressor Protein p53 | 2009 |
MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation.
Topics: Adenine; Adenosine Triphosphate; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein 7; Blotting, Western; Cell Survival; Glucose; HCT116 Cells; Humans; Hydrogen Peroxide; Microtubule-Associated Proteins; Mucin-1; Necrosis; Oxidative Stress; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Ubiquitin-Activating Enzymes | 2009 |
Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glioma; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases; Transfection | 2009 |
Effect of autophagy on multiple myeloma cell viability.
Topics: Adenine; Antifungal Agents; Antimalarials; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Cell Proliferation; Chloroquine; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Immunoblotting; Membrane Proteins; Microscopy, Fluorescence; Multiple Myeloma; Pyrazines; RNA, Small Interfering; Sirolimus; Thapsigargin; Tumor Cells, Cultured | 2009 |
Postischemic treatment of neonatal cerebral ischemia should target autophagy.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; Brain; Brain Ischemia; Caspase Inhibitors; Caspases; Cell Death; Immunohistochemistry; Injections, Intraventricular; Ischemic Attack, Transient; Lysosomes; Male; Microscopy, Electron; Necrosis; Neurons; Neuroprotective Agents; Phagosomes; Rats; Rats, Sprague-Dawley | 2009 |
Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum.
Topics: Adenine; Analysis of Variance; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Beclin-1; Benzopyrans; Blotting, Western; Cell Death; Corpus Striatum; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Mitochondria; Neurotoxins; Nitriles; Nitro Compounds; Propionates; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; Time Factors; Up-Regulation | 2009 |
Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia.
Topics: Adenine; Analysis of Variance; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Endosomal Sorting Complexes Required for Transport; Green Fluorescent Proteins; Humans; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mutation; Nerve Tissue Proteins; Neurons; Propidium; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Time Factors; Transfection | 2009 |
Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Colonic Neoplasms; Dose-Response Relationship, Drug; Fluorouracil; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2010 |
High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells.
Topics: Adenine; Animals; Base Sequence; CHO Cells; Cricetinae; Cricetulus; DNA Methylation; Hypoxanthine Phosphoribosyltransferase; Mutagens; Sequence Deletion | 2009 |
Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Line; Culture Media, Serum-Free; Hippocampus; Macrolides; Mice; Microtubule-Associated Proteins; Nerve Degeneration | 2009 |
Roles of mitophagy and the mitochondrial permeability transition in remodeling of cultured rat hepatocytes.
Topics: Adenine; Amines; Animals; Autophagy; Biological Transport; Cell Compartmentation; Cells, Cultured; Cyclosporine; Cytochromes c; DNA, Mitochondrial; Electron Transport Complex IV; Gene Expression Regulation; Hepatocytes; Lysosomes; Male; Mitochondria, Liver; Permeability; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phagosomes; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2009 |
Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Cycle; Cell Hypoxia; Cisplatin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Knockdown Techniques; Green Fluorescent Proteins; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Proteins | 2009 |
Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43.
Topics: Acetylcysteine; Adenine; Analysis of Variance; Autophagy; Cell Line, Tumor; Cell Nucleus; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Green Fluorescent Proteins; Humans; Mutation; Neuroblastoma; Proteasome Endopeptidase Complex; Protein Transport; Subcellular Fractions; Transfection; Ubiquitin-Protein Ligases; Ubiquitination | 2010 |
Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; Gene Knockdown Techniques; GTPase-Activating Proteins; Humans; Hydrolyzable Tannins; Male; Membrane Proteins; Mice; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms; Protein Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sirolimus; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay | 2009 |
Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells.
Topics: Adenine; Anticarcinogenic Agents; Apoptosis; Autophagy; Blotting, Western; Caspases; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Colony-Forming Units Assay; Cytochromes c; Flow Cytometry; Humans; Isothiocyanates; Sulfoxides; Thiocyanates | 2010 |
Basal autophagy induction without AMP-activated protein kinase under low glucose conditions.
Topics: Adenine; Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Culture Media, Serum-Free; Embryo, Mammalian; Fibroblasts; Glucose; Mice; Microtubule-Associated Proteins; Models, Biological; Phosphoserine; PTEN Phosphohydrolase; Time Factors; Tumor Suppressor Protein p53 | 2009 |
Mutagenicity of N3-methyladenine: a multi-translesion polymerase affair.
Topics: Adenine; DNA Damage; DNA-Directed DNA Polymerase; DNA, Fungal; Gene Deletion; Mutagenesis; Mutation; Netropsin; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tumor Suppressor Protein p53 | 2010 |
Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Doxorubicin; GATA4 Transcription Factor; Gene Expression Regulation; Gene Knockdown Techniques; Microtubule-Associated Proteins; Myocytes, Cardiac; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sirolimus | 2010 |
A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy.
Topics: Adenine; Apoptosis; Autophagy; Cell Survival; Colonic Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Genistein; HT29 Cells; Humans; Indoles; Phagosomes; Phosphorylation; Proto-Oncogene Proteins c-akt | 2009 |
Autophagy is involved in starvation response and cell death in Blastocystis.
Topics: Adenine; Androstadienes; Autophagy; Blastocystis; Microscopy, Confocal; Microscopy, Electron, Transmission; Sirolimus; Vacuoles; Wortmannin | 2010 |
Bortezomib induces autophagic death in proliferating human endothelial cells.
Topics: Adenine; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Endothelial Cells; Fibroblast Growth Factors; Humans; Microtubule-Associated Proteins; Multiple Myeloma; Protease Inhibitors; Pyrazines; Reactive Oxygen Species | 2010 |
S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Calgranulin A; Calgranulin B; Cell Line; Humans; Lysosomes; Macrolides; Membrane Proteins; Microtubule-Associated Proteins; Mitochondria; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins; Reactive Oxygen Species; Small Ubiquitin-Related Modifier Proteins; Vacuolar Proton-Translocating ATPases | 2010 |
Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system.
Topics: Adenine; Autophagy; Cell Line; DNA-Binding Proteins; Humans; Leupeptins; Pepstatins; Peptide Fragments; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Trehalose; Ubiquitin | 2010 |
Autophagy: a new target for advanced papillary thyroid cancer therapy.
Topics: Adenine; Antibiotics, Antineoplastic; Autophagy; Carcinoma, Papillary; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Humans; In Vitro Techniques; Microtubule-Associated Proteins; Radiation Tolerance; Thyroid Neoplasms | 2009 |
Autophagy impairment inhibits differentiation of glioma stem/progenitor cells.
Topics: Adenine; Autophagy; Blotting, Western; Cadaverine; Cell Differentiation; Cells, Cultured; Central Nervous System Agents; Glioma; Humans; Immunohistochemistry; Macrolides; Microscopy, Electron, Transmission; Neurons; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus; Stem Cells; Transduction, Genetic | 2010 |
Temporal relationship of autophagy and apoptosis in neurons challenged by low molecular weight β-amyloid peptide.
Topics: Adenine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Calcium-Calmodulin-Dependent Protein Kinases; Caspase 3; Cells, Cultured; Death-Associated Protein Kinases; Neurons; Phosphorylation; Poly(ADP-ribose) Polymerases; Rats; Signal Transduction | 2011 |
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Proliferation; Cisplatin; Cytochromes c; Drug Synergism; Esophageal Neoplasms; Flow Cytometry; Humans; Tumor Cells, Cultured | 2011 |
The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; bcl-X Protein; Cell Line; Flavonoids; Humans; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidylinositol 3-Kinases; Receptor, EphB2; RNA Interference; Signal Transduction; Ubiquitin-Activating Enzymes | 2010 |
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells.
Topics: Adenine; Aldehydes; Ammonium Chloride; Animals; Autophagy; Cell Line; Flow Cytometry; Humans; Lipid Peroxidation; Lipofuscin; Lysosomes; Malondialdehyde; Microscopy, Fluorescence; Oxidative Stress; Phagocytosis; Retinal Photoreceptor Cell Outer Segment; Retinal Pigment Epithelium; Swine | 2010 |
Gangliosides induce autophagic cell death in astrocytes.
Topics: Adenine; Astrocytes; Autophagy; Cell Death; Cell Line; Gangliosides; Glioma; Humans; Lysosomes; Microtubule-Associated Proteins; Reactive Oxygen Species; Signal Transduction | 2010 |
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line; Chloroquine; Cytoprotection; Gene Knockdown Techniques; Hypoxia; Kidney; Kidney Tubules, Proximal; Mice; Mice, Inbred C57BL; Proteins; Rats; Reperfusion Injury; Vacuoles | 2010 |
p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms.
Topics: Adenine; Animals; Apoptosis; Autophagy; Benzothiazoles; Cell Death; Corpus Striatum; DNA Fragmentation; Genes, p53; Neurons; Neurotoxins; NF-kappa B; Peptides; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Toluene; Transcriptional Activation; Tumor Suppressor Protein p53 | 2009 |
Autophagy modification augmented the treatment effects initiated by arsenic trioxide in NB4 cells.
Topics: Adenine; Antibiotics, Antineoplastic; Apoptosis; Arsenic Trioxide; Arsenicals; Autophagy; Cell Line, Tumor; Cell Survival; Flow Cytometry; Humans; Leukemia, Promyelocytic, Acute; Oxides; Sirolimus | 2011 |
Role of hypoxia and autophagy in MDA-MB-231 invasiveness.
Topics: Adenine; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cell Migration Assays; Cell Movement; Cell Survival; Cytoskeleton; Disulfides; Dopamine Antagonists; Extracellular Matrix; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indole Alkaloids; Matrix Metalloproteinase 2; Matrix Metalloproteinases; Microtubule-Associated Proteins; Neoplasm Invasiveness; Neoplasms; Oxygen Consumption; Phagosomes; RNA Interference; Trifluoperazine | 2010 |
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 7; Blotting, Western; Embryo, Mammalian; Fibroblasts; Immunoprecipitation; Lysosomes; Mice; Microtubule-Associated Proteins; Phagosomes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Wortmannin | 2010 |
A preliminary investigation of the additivity of pi-pi or pi+-pi stacking and T-shaped interactions between natural or damaged DNA nucleobases and histidine.
Topics: Adenine; Dimerization; DNA; DNA Damage; Histidine; Quantum Theory; Thermodynamics | 2010 |
Regulation of the autophagic machinery in human neutrophils.
Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hydrogen-Ion Concentration; Inflammation; Microscopy, Confocal; Morpholines; Neutrophils; Phagosomes; Poly I-C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sirolimus; Small Ubiquitin-Related Modifier Proteins; Tetradecanoylphorbol Acetate; Toll-Like Receptors; Transcription, Genetic; Vacuoles | 2010 |
Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Death; Cells, Cultured; Central Nervous System Agents; Cerebellum; Lysosomes; N-Methylaspartate; Nerve Degeneration; Neurons; Neurotoxins; Phenotype; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors | 2010 |
A novel sphingosine kinase inhibitor induces autophagy in tumor cells.
Topics: Adamantane; Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Mice; Mice, SCID; Microscopy, Confocal; Microtubule-Associated Proteins; Mitochondrial Membranes; Neoplasm Transplantation; Neoplasms, Experimental; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Pyridines; RNA, Small Interfering; Tumor Cells, Cultured; Unfolded Protein Response | 2010 |
Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model.
Topics: Adenine; AMP-Activated Protein Kinase Kinases; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinases; Random Allocation; RNA, Small Interfering; Transplantation, Heterologous; Tumor Suppressor Protein p53; Ubiquitin-Activating Enzymes | 2010 |
Gemcitabine induces the VMP1-mediated autophagy pathway to promote apoptotic death in human pancreatic cancer cells.
Topics: Adenine; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Deoxycytidine; Gemcitabine; Gene Knockdown Techniques; Humans; Membrane Proteins; Pancreatic Neoplasms; Vacuoles | 2010 |
Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Autophagy; Caspases; Cathepsin B; Cathepsin L; Cell Line, Tumor; Dipeptides; Down-Regulation; Epoxy Compounds; Glioblastoma; Humans; Macrolides; Oxides; Pyridines | 2010 |
Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.
Topics: Adenine; Adenosine Triphosphatases; Animals; Autophagy; Binding Sites; Catalysis; Catalytic Domain; Cell Membrane; Crystallography, X-Ray; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Furans; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridines; Pyrimidines | 2010 |
AKT loss in human epithelial cells treated with severe hypoxia.
Topics: Adenine; Autophagy; Calpain; Chromones; Enzyme Inhibitors; Epithelial Cells; HeLa Cells; Humans; Hypoxia; Intracellular Signaling Peptides and Proteins; Morpholines; Oxygen; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2010 |
Induction of autophagy by cystatin C: a mechanism that protects murine primary cortical neurons and neuronal cell lines.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line; Colchicine; Cystatin C; Enzyme Inhibitors; Lysosomes; Mice; Neurodegenerative Diseases; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley; Staurosporine; TOR Serine-Threonine Kinases; Tubulin Modulators | 2010 |
Involvement of autophagy via mammalian target of rapamycin (mTOR) inhibition in tributyltin-induced neuronal cell death.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Death; Cells, Cultured; Female; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Neurons; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; TOR Serine-Threonine Kinases; Trialkyltin Compounds | 2010 |
Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models, Animal; Down-Regulation; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Ischemic Preconditioning; Male; Microtubule-Associated Proteins; Neostriatum; Neurogenesis; Neurons; Neuroprotective Agents; Phagosomes; Rats; Rats, Sprague-Dawley; Sequestosome-1 Protein; Sirolimus; Up-Regulation | 2010 |
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Differentiation; Cell Polarity; Drug Resistance; Gene Knockdown Techniques; Graft vs Host Disease; Humans; Immunologic Memory; Interferon-alpha; Interleukin-12; Lipopolysaccharides; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Transgenic; Phenotype; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Sirolimus; STAT Transcription Factors; T-Lymphocytes, Cytotoxic; Th1 Cells; Tumor Necrosis Factor-alpha | 2010 |
Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines.
Topics: Adenine; Amitrole; Apoptosis; Autophagy; Capsaicin; Catalase; Cell Line, Tumor; Enzyme Activation; Epithelial Cells; Humans; Lung; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA, Small Interfering; Sirolimus | 2010 |
Mechanisms of axonal spheroid formation in central nervous system Wallerian degeneration.
Topics: Adenine; Animals; Axons; Axotomy; Calcimycin; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; In Vitro Techniques; Ionophores; Luminescent Proteins; Lysosomal-Associated Membrane Protein 2; Mice; Mice, Transgenic; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitochondria; Nerve Tissue Proteins; Neural Pathways; Optic Nerve; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Time Factors; Wallerian Degeneration | 2010 |
Silibinin induced autophagic and apoptotic cell death in HT1080 cells through a reactive oxygen species pathway.
Topics: Acetylcysteine; Adenine; Antioxidants; Apoptosis; Autophagy; Cell Line; Culture Media, Serum-Free; Drug Interactions; Humans; Hydrogen Peroxide; Reactive Oxygen Species; Signal Transduction; Silybin; Silymarin | 2010 |
Acute axonal degeneration in vivo is attenuated by inhibition of autophagy in a calcium-dependent manner.
Topics: Adenine; Animals; Autophagy; Axons; Calcium; Humans; MCF-7 Cells; Nerve Crush; Nerve Degeneration; Optic Nerve; Rats | 2010 |
XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine.
Topics: Adenine; Alkylating Agents; Animals; CHO Cells; Cricetinae; Cricetulus; DNA Damage; DNA-Binding Proteins; Genomic Instability; Mutagens; Netropsin; Sequence Deletion; X-ray Repair Cross Complementing Protein 1 | 2010 |
Glucocorticoid-induced autophagy in osteocytes.
Topics: Adenine; Animals; Apoptosis; Autophagy; Biomarkers; Cell Count; Cell Line; Chickens; Dexamethasone; Glucocorticoids; Microtubule-Associated Proteins; Osteocytes; Phagosomes; Rats | 2010 |
Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Binding Sites; Catalytic Domain; Endosomal Sorting Complexes Required for Transport; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors | 2010 |
Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Beclin-1; Brain Ischemia; Cathepsin B; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Glial Fibrillary Acidic Protein; Glucose; Infarction, Middle Cerebral Artery; Lysosomal-Associated Membrane Protein 2; Male; Microtubule-Associated Proteins; Oxygen; Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Vacuoles | 2010 |
A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species.
Topics: Acetylcysteine; Adenine; Agaricales; Antineoplastic Agents; Autophagy; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Free Radical Scavengers; Humans; Liver Neoplasms; Microtubule-Associated Proteins; Reactive Oxygen Species; Sesquiterpenes | 2010 |
Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cells, Cultured; Embryo, Mammalian; Enzyme Inhibitors; Fibroblasts; Gene Knockdown Techniques; Inflammation; Interferon-gamma; Janus Kinase 2; Lentivirus; Mice; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Reactive Oxygen Species; Signal Transduction; STAT1 Transcription Factor | 2010 |
Pterostilbene induces autophagy and apoptosis in sensitive and chemoresistant human bladder cancer cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Signal Transduction; Stilbenes; Urinary Bladder Neoplasms | 2010 |
3-Methyladenine blocks Toxoplasma gondii division prior to centrosome replication.
Topics: Adenine; Antiprotozoal Agents; Centrosome; Cytokinesis; DNA Replication; Golgi Apparatus; Lysosomes; Microscopy, Electron, Transmission; Toxoplasma; Vacuoles | 2010 |
Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage.
Topics: Adenine; Animals; Anthracenes; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Endoplasmic Reticulum; Gene Expression; Glutathione Peroxidase; Humans; Mice; Microtubule-Associated Proteins; Molecular Chaperones; Oncogene Protein v-akt; Perylene; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species; Thapsigargin; TOR Serine-Threonine Kinases | 2011 |
Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation.
Topics: Adenine; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Autophagy; Blotting, Western; Cells, Cultured; Collagen; Dihydroalprenolol; Dose-Response Relationship, Drug; Fibroblasts; Isoproterenol; Male; Microscopy, Electron, Transmission; Myocardium; Norepinephrine; Propanolamines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-2; Tritium | 2011 |
Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Drug Screening Assays, Antitumor; Gossypol; Growth Inhibitors; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2010 |
Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Benzoquinones; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mitochondria; Multiple Myeloma | 2010 |
Heavy ion irradiation induces autophagy in irradiated C2C12 myoblasts and their bystander cells.
Topics: Adenine; Animals; Autophagy; Bystander Effect; Cell Line; Heavy Ions; Lysosomes; Mice; Microscopy, Confocal; Microtubule-Associated Proteins; Multivesicular Bodies; Myoblasts | 2010 |
DJ-1 as a modulator of autophagy: an hypothesis.
Topics: Adenine; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; Cytochromes c; Enzyme Activation; Herbicides; Humans; Intracellular Signaling Peptides and Proteins; Membrane Potential, Mitochondrial; Models, Biological; Neuroblastoma; Oncogene Proteins; Paraquat; Protein Deglycase DJ-1; Reactive Oxygen Species; RNA Interference | 2010 |
The role of autophagy in the treatment of pancreatic cancer with gemcitabine and ionizing radiation.
Topics: Adenine; Animals; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemotherapy, Adjuvant; Deoxycytidine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gemcitabine; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Scanning; Microtubule-Associated Proteins; Pancreatic Neoplasms; Radiotherapy, Adjuvant; Time Factors; Tumor Burden; Up-Regulation; Xenograft Model Antitumor Assays | 2010 |
Acute phase expression pattern of ZnTs, LC3, and beclin-1 in rat Hippocampus and its regulation by 3-methyladenine following recurrent neonatal seizures.
Topics: Adenine; Animals; Blotting, Western; Cation Transport Proteins; Hippocampus; Microtubule-Associated Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Seizures | 2011 |
Structure of Escherichia coli AlkA in complex with undamaged DNA.
Topics: Adenine; Binding Sites; Crystallography, X-Ray; DNA Damage; DNA Glycosylases; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Hydrogen Bonding; Models, Molecular; Molecular Structure; Mutation; Nucleic Acid Conformation; Protein Binding; Protein Structure, Tertiary; Transition Temperature | 2010 |
Role of autophagy in sonodynamic therapy-induced cytotoxicity in S180 cells.
Topics: Adenine; Analysis of Variance; Animals; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Cell Line, Tumor; Macrolides; Mice; Microscopy, Confocal; Sarcoma 180; Staining and Labeling; Ultrasonic Therapy | 2010 |
Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Screening Assays, Antitumor; Drug Synergism; Endoplasmic Reticulum; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; Macrolides; Mice; Microtubule-Associated Proteins; Phagosomes; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Vorinostat | 2010 |
β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells.
Topics: Adenine; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flow Cytometry; Glioma; Humans; Macrolides; Microscopy, Fluorescence; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; Reactive Oxygen Species; RNA, Small Interfering | 2011 |
Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts.
Topics: Adenine; Animals; Antimitotic Agents; Apoptosis; Autophagy; Caspase 3; Cell Line, Transformed; Dose-Response Relationship, Drug; Fibroblasts; Genes, ras; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; NIH 3T3 Cells; Paclitaxel; Proto-Oncogene Proteins c-raf; Recombinant Fusion Proteins; RNA Interference; Transfection; X-Linked Inhibitor of Apoptosis Protein | 2011 |
Minocycline inhibits the growth of glioma by inducing autophagy.
Topics: Adenine; Animals; Astrocytes; Autophagy; Cell Line, Tumor; Cell Proliferation; Gene Knockdown Techniques; Glioma; Mice; Mice, Nude; Minocycline; Organelles; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Small Interfering; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2011 |
Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; DNA, Mitochondrial; Fasting; Green Fluorescent Proteins; Hepatocytes; Lysosomes; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Mitochondria, Liver; Phagosomes; Rats; Recombinant Fusion Proteins | 2011 |
Normal prion protein in Drosophila enhances the toxicity of pathogenic polyglutamine proteins and alters susceptibility to oxidative and autophagy signaling modulators.
Topics: Adenine; Animals; Animals, Genetically Modified; Autophagy; Disease Models, Animal; Dithiothreitol; Drosophila melanogaster; Eye; Lithium Chloride; Machado-Joseph Disease; Mice; Models, Genetic; Neurons; Oxidative Stress; Paraquat; Peptides; Prions; Unfolded Protein Response; Water | 2011 |
Optimization of filaggrin expression and processing in cultured rat keratinocytes.
Topics: Adenine; Animals; Autophagy; Calcium; Cell Differentiation; Cells, Cultured; Cellular Senescence; Culture Techniques; Filaggrin Proteins; Guanidines; Intermediate Filament Proteins; Keratinocytes; Rats | 2011 |
Autophagy in human keratinocytes: an early step of the differentiation?
Topics: Adaptor Proteins, Signal Transducing; Adenine; Adenylate Kinase; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Autophagy-Related Protein 8 Family; bcl-X Protein; Beclin-1; Calcium; Cathepsin B; Cell Cycle; Cell Differentiation; Cell Line, Transformed; Culture Media, Serum-Free; Humans; Integrin beta1; Keratin-10; Keratinocytes; Membrane Proteins; Microfilament Proteins; Microtubule-Associated Proteins; Phosphorylation; Protein Precursors; Sirtuin 1; Small Ubiquitin-Related Modifier Proteins; Stress, Physiological; Transcription Factors; Tumor Suppressor Proteins | 2011 |
Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Survival; Esophageal Neoplasms; G2 Phase Cell Cycle Checkpoints; Humans; Membrane Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Radiation, Ionizing; Tumor Cells, Cultured | 2011 |
Possible involvement of Class III phosphatidylinositol-3-kinase in meiotic progression of porcine oocytes beyond germinal vesicle stage.
Topics: Adenine; Animals; Cells, Cultured; Cumulus Cells; Embryo Culture Techniques; Enzyme Inhibitors; Female; Fertilization in Vitro; Meiosis; Metaphase; Oocytes; Parthenogenesis; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Swine | 2011 |
Inhibition of AMPK-associated autophagy enhances caffeic acid phenethyl ester-induced cell death in C6 glioma cells.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Caffeic Acids; Cell Death; Cell Line, Tumor; Down-Regulation; Drug Synergism; Glioma; Humans; Membrane Potential, Mitochondrial; Mitogen-Activated Protein Kinases; Oxidative Stress; Phenylethyl Alcohol; Phosphorylation; Pyrazoles; Pyrimidines; Rats; RNA, Small Interfering | 2011 |
Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Down-Regulation; Humans; Melanoma; Mitomycin; NF-kappa B; Pyrrolidines; Silybin; Silymarin; Thiocarbamates; Time Factors; Tumor Suppressor Protein p53 | 2011 |
Autophagy inhibition enhances etoposide-induced cell death in human hepatoma G2 cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; DNA Damage; Etoposide; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Proteins; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Protein p53 | 2011 |
Targeting autophagy augments in vitro and in vivo antimyeloma activity of DNA-damaging chemotherapy.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; DNA Damage; Doxorubicin; Drug Synergism; Humans; Melphalan; Mice; Mice, Inbred C57BL; Mice, SCID; Molecular Targeted Therapy; Multiple Myeloma; Xenograft Model Antitumor Assays | 2011 |
Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Carcinoma, Squamous Cell; Cells, Cultured; Cisplatin; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Keratinocytes; Lymphatic Metastasis; Membrane Potential, Mitochondrial; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-akt; Skin Neoplasms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
Autophagy regulates embryonic survival during delayed implantation.
Topics: Adenine; Animals; Autophagy; Blastocyst; Cell Survival; Embryo Implantation; Embryo, Mammalian; Estrogens; Female; Green Fluorescent Proteins; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Multivesicular Bodies; Pregnancy; Time Factors | 2011 |
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adenine; Autophagy; Autophagy-Related Proteins; Carrier Proteins; Caspase 1; Cells, Cultured; Crohn Disease; Cytokines; Enzyme Activation; Gene Expression; Genetic Predisposition to Disease; Humans; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Nod2 Signaling Adaptor Protein; Polymorphism, Genetic; RNA, Messenger | 2011 |
Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy.
Topics: Adenine; Animals; Autophagy; Blotting, Western; Brain Ischemia; CA1 Region, Hippocampal; Caspase 3; Cathepsin B; Cell Count; Cell Death; Immunohistochemistry; In Situ Nick-End Labeling; Male; Microscopy, Electron, Transmission; Necrosis; Neurons; Rats; Rats, Sprague-Dawley | 2011 |
Autophagy activation in the injured photoreceptor inhibits fas-mediated apoptosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Caspase 8; Cathepsin B; Cathepsin D; Cell Line; Enzyme Activation; fas Receptor; Immunohistochemistry; Male; Microtubule-Associated Proteins; Photoreceptor Cells, Vertebrate; Protein Isoforms; Proteins; Rats; Rats, Inbred BN; Retinal Detachment; RNA, Small Interfering; Time Factors | 2011 |
STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Beclin-1; Cardiotonic Agents; Heart; Mice; Mice, Knockout; Microtubule-Associated Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Proteins; STAT1 Transcription Factor; Tumor Suppressor Protein p53 | 2012 |
Sensitizing effect of 3-methyladenine on radiation-induced cytotoxicity in radio-resistant HepG2 cells in vitro and in tumor xenografts.
Topics: Adenine; Animals; Apoptosis; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Radiation Tolerance; Radiation-Sensitizing Agents; Xenograft Model Antitumor Assays | 2011 |
GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Calcium; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Cell Survival; Fungal Proteins; Ganoderma; Gene Silencing; Immunologic Factors; Lung Neoplasms; Mice; Microtubule-Associated Proteins; Signal Transduction; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2011 |
Inflammasome-independent modulation of cytokine response by autophagy in human cells.
Topics: Adenine; Autophagy; Blotting, Western; Cells, Cultured; Cytokines; Enzyme-Linked Immunosorbent Assay; Humans; Inflammasomes; Interleukin-10; Interleukin-1beta; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Tumor Necrosis Factor-alpha | 2011 |
Autophagy's expanding role in development: implantation is next.
Topics: Adenine; Animals; Autophagy; Blastocyst; Cell Survival; Embryo Implantation; Embryo, Mammalian; Estrogens; Female; Mice; Microtubule-Associated Proteins; Multivesicular Bodies; Pregnancy; Time Factors | 2011 |
Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Proliferation; Chalcones; Colorectal Neoplasms; Gene Expression; HCT116 Cells; Humans; Membrane Proteins; Microtubule-Associated Proteins; RNA Interference | 2011 |
Interferon gamma activated macrophages kill mycobacteria by nitric oxide induced apoptosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Caspase 7; Cell Survival; Interferon-gamma; Interleukin-4; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Mycobacterium tuberculosis; Nitric Oxide; Stem Cells | 2011 |
Role of ROS in the protective effect of silibinin on sodium nitroprusside-induced apoptosis in rat pheochromocytoma PC12 cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; MAP Kinase Kinase 1; NF-kappa B; Nitroprusside; Oncogene Protein p21(ras); PC12 Cells; Phosphatidylinositol 3-Kinases; raf Kinases; Rats; Reactive Oxygen Species; Silybin; Silymarin; Sirolimus | 2011 |
Adenoviruses induce autophagy to promote virus replication and oncolysis.
Topics: Adenine; Adenoviridae; Adenovirus E1A Proteins; Adenovirus E1B Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Cell Line, Tumor; Gene Expression Regulation, Viral; Humans; Microtubule-Associated Proteins; Mutation; Small Ubiquitin-Related Modifier Proteins; Virus Replication | 2011 |
A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling.
Topics: Acute Lung Injury; Adenine; Animals; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Survival; Gene Silencing; Humans; Lung; Male; Mice; Microscopy, Electron; Nanotubes, Carbon; Phagosomes; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2011 |
Fission yeast homologs of human XPC and CSB, rhp41 and rhp26, are involved in transcription-coupled repair of methyl methanesulfonate-induced DNA damage.
Topics: Adenine; DNA Breaks, Single-Stranded; DNA Helicases; DNA Primers; DNA Repair; DNA Repair Enzymes; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Binding Proteins; Electrophoresis, Agar Gel; Gene Expression Regulation, Fungal; Humans; Methyl Methanesulfonate; Mutation; Poly-ADP-Ribose Binding Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Survival Analysis | 2011 |
2-methoxyestradiol attenuates autophagy activation after global ischemia.
Topics: 2-Methoxyestradiol; Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Male; Membrane Proteins; Microtubule-Associated Proteins; Mitochondrial Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tubulin Modulators; Tumor Suppressor Protein p53; Up-Regulation | 2011 |
PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway.
Topics: Adenine; Animals; Apoptosis; Autophagy; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Mice; Microtubule-Associated Proteins; Neoplasm Transplantation; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-akt; Recombinant Fusion Proteins; Time Factors; TOR Serine-Threonine Kinases; U937 Cells | 2011 |
Modulation of autophagy influences development and apoptosis in mouse embryos developing in vitro.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blastocyst; Cell Nucleus; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Histocytochemistry; Male; Mice; Mice, Inbred ICR; Microscopy, Confocal; Mitochondria; Morula; Octamer Transcription Factor-3; Sirolimus | 2011 |
PM02734 (elisidepsin) induces caspase-independent cell death associated with features of autophagy, inhibition of the Akt/mTOR signaling pathway, and activation of death-associated protein kinase.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Death-Associated Protein Kinases; Depsipeptides; Enzyme Activation; Green Fluorescent Proteins; Humans; Immunoblotting; Lung Neoplasms; Mice; Mice, Nude; Microscopy, Fluorescence; Microtubule-Associated Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2011 |
Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy.
Topics: Adenine; Autophagy; Cell Death; Cell Survival; Humans; Neoplasms; Radiation Tolerance; Tumor Cells, Cultured; X-Rays | 2011 |
Autophagy contributes to resistance of tumor cells to ionizing radiation.
Topics: Adenine; Autophagy; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electrophoresis, Polyacrylamide Gel; Female; Humans; Microtubule-Associated Proteins; Radiation Tolerance; Signal Transduction; Tumor Cells, Cultured | 2011 |
Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Deferoxamine; Free Radicals; Gene Silencing; Humans; Hydrogen Peroxide; Hydroxyl Radical; Lysosomes; Membrane Proteins; Mitochondria; Neuroblastoma; Oncogene Protein v-akt; Oxidants; Phosphorylation; RNA, Small Interfering; Siderophores | 2011 |
Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure.
Topics: Acid Phosphatase; Adenine; Animals; Apoptosis; Astrocytes; Autophagy; Caspase 3; Cell Count; Drug Design; Endocytosis; Intraocular Pressure; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retina; Retinal Ganglion Cells; Time Factors | 2011 |
The β-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Harmine; Humans; Microscopy, Electron; Nitriles; Phytotherapy; Plant Extracts; RNA, Small Interfering | 2011 |
Up-regulated autophagy by endogenous high mobility group box-1 promotes chemoresistance in leukemia cells.
Topics: Adenine; Autophagy; Blotting, Western; Cell Proliferation; Cells, Cultured; Child; Drug Resistance, Neoplasm; HMGB1 Protein; Human Umbilical Vein Endothelial Cells; Humans; Immunoprecipitation; Leukemia; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; TOR Serine-Threonine Kinases; Up-Regulation | 2012 |
Silibinin induced-autophagic and apoptotic death is associated with an increase in reactive oxygen and nitrogen species in HeLa cells.
Topics: Acetylcysteine; Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Survival; Glutathione; HeLa Cells; Humans; Hydroxyl Radical; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Reactive Nitrogen Species; Reactive Oxygen Species; Silybin; Silymarin | 2011 |
Modeling the chemical step utilized by human alkyladenine DNA glycosylase: a concerted mechanism AIDS in selectively excising damaged purines.
Topics: Adenine; DNA; DNA Glycosylases; DNA Repair; Humans; Models, Molecular; Point Mutation; Thermodynamics | 2011 |
Chikungunya triggers an autophagic process which promotes viral replication.
Topics: Adenine; Alphavirus Infections; Antimetabolites; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Chikungunya Fever; Chikungunya virus; Disease Outbreaks; Europe; Gene Silencing; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunosuppressive Agents; Indian Ocean; Membrane Proteins; Microscopy, Electron; Microscopy, Fluorescence; Phagosomes; Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Sirolimus; Virus Replication | 2011 |
Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A.
Topics: Adenine; Animals; Apoptosis; Autophagy; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Fibrosis; Gene Expression Regulation; Injections; Laminin; Leupeptins; Mice; Motor Activity; Muscles; Muscular Atrophy; Muscular Dystrophies; Peripheral Nervous System Diseases; Phenotype; Phosphorylation; Proto-Oncogene Proteins c-akt; Regeneration; Survival Analysis | 2011 |
Human Pompe disease-induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification.
Topics: Adenine; alpha-Glucosidases; Animals; Base Sequence; Biomarkers; Carnitine; Cell Differentiation; Drug Monitoring; Fibroblasts; Glycogen Storage Disease Type II; Humans; Induced Pluripotent Stem Cells; Mice; Models, Biological; Molecular Sequence Data; Myocytes, Cardiac | 2011 |
Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Proliferation; Curcumin; Down-Regulation; HL-60 Cells; Humans; Leukemia, Myeloid; MAP Kinase Signaling System; Membrane Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2011 |
An autophagy inhibitor enhances the inhibition of cell proliferation induced by a proteasome inhibitor in MCF-7 cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Green Fluorescent Proteins; Humans; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Recombinant Fusion Proteins | 2012 |
Activation of autophagy protects against acetaminophen-induced hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Adenine; Analgesics, Non-Narcotic; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Green Fluorescent Proteins; Hepatocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Primary Cell Culture; TOR Serine-Threonine Kinases | 2012 |
Rapamycin induces differentiation of glioma stem/progenitor cells by activating autophagy.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Female; Glial Fibrillary Acidic Protein; Glioma; Humans; Leucine; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins; Neoplastic Stem Cells; RNA, Messenger; Sirolimus; Xenograft Model Antitumor Assays | 2011 |
Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity.
Topics: Adenine; Antioxidants; Apoptosis; Astrocytes; Astrocytoma; Autophagy; Cell Line, Tumor; Cells, Cultured; Cellular Senescence; Drug Interactions; Humans; Oxidative Stress; Phenazines; Pyocyanine; Reactive Oxygen Species | 2012 |
Rapamycin causes upregulation of autophagy and impairs islets function both in vitro and in vivo.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Green Fluorescent Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Transgenic; Microscopy, Fluorescence; Sirolimus; Up-Regulation | 2012 |
[Autophagy inhibitor 3-MA decreases the production and release of infectious enterovirus 71 particles].
Topics: Adenine; Antiviral Agents; Autophagy; Cell Line, Tumor; Enterovirus; Humans | 2011 |
Decreases in valosin-containing protein result in increased levels of tau phosphorylated at Ser262/356.
Topics: Adenine; Adenosine Triphosphatases; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Autophagy; Cell Cycle Proteins; Cerebral Cortex; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Male; Mice; Middle Aged; Neurons; Phosphoproteins; Phosphorylation; Rats; Serine; Solubility; tau Proteins; Valosin Containing Protein | 2011 |
Heat shock protein 72 enhances autophagy as a protective mechanism in lipopolysaccharide-induced peritonitis in rats.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Cells, Cultured; Chloroquine; Diterpenes; Dose-Response Relationship, Drug; Epithelial Cells; Green Fluorescent Proteins; HSP72 Heat-Shock Proteins; Lipopolysaccharides; Luminescent Agents; Male; MAP Kinase Signaling System; Peritoneal Cavity; Peritonitis; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Up-Regulation | 2011 |
Inhibition of autophagy enhances cisplatin cytotoxicity through endoplasmic reticulum stress in human cervical cancer cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Proliferation; Chloroquine; Cisplatin; Endoplasmic Reticulum Stress; Endoribonucleases; Female; HeLa Cells; Humans; MAP Kinase Signaling System; Membrane Proteins; Protein Serine-Threonine Kinases; Tunicamycin; Uterine Cervical Neoplasms | 2012 |
Role of autophagy in angiogenesis in aortic endothelial cells.
Topics: Adenine; Animals; Aorta; Autophagy; Cattle; Cells, Cultured; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Integrin alphaV; Microtubule-Associated Proteins; Neovascularization, Physiologic; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Vascular Endothelial Growth Factor A | 2012 |
Dendrimer-mediated siRNA delivery knocks down Beclin 1 and potentiates NMDA-mediated toxicity in rat cortical neurons.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Calcium; Cells, Cultured; Cerebral Cortex; Dendrites; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Intracellular Fluid; L-Lactate Dehydrogenase; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Rats; RNA, Small Interfering; Transfection | 2012 |
Autophagy in tobacco BY-2 cells cultured under sucrose starvation conditions: isolation of the autolysosome and its characterization.
Topics: Adenine; Autophagy; Blotting, Western; Cell Fractionation; Cells, Cultured; Cysteine Proteases; Endocytosis; Fluorescent Antibody Technique; Leucine; Lysosomes; Nicotiana; Plant Proteins; Staining and Labeling; Sucrose | 2011 |
Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.
Topics: Activating Transcription Factor 6; Adenine; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Calpain; Cell Line, Tumor; Ceramides; Down-Regulation; Doxorubicin; eIF-2 Kinase; Endoribonucleases; Female; Gene Silencing; Humans; Lysophospholipids; Membrane Proteins; Microtubule-Associated Proteins; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Proteolysis; Sphingosine | 2011 |
The role of autophagy in unilateral ureteral obstruction rat model.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Proliferation; Cytoprotection; Disease Models, Animal; Fibrosis; Injections, Intraperitoneal; Kidney; Kidney Tubules; Male; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Ureteral Obstruction | 2012 |
The role of autophagy in human endometrium.
Topics: Adenine; Adult; Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cells, Cultured; Endometrium; Female; Homeostasis; Humans; Macrolides; Menstrual Cycle; Microtubule-Associated Proteins; Middle Aged; Proto-Oncogene Proteins c-bcl-2 | 2012 |
Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells.
Topics: Adenine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Differentiation; Cell Nucleus; Cell Survival; Down-Regulation; Humans; Intracellular Space; Lysosomal Membrane Proteins; Lysosomal-Associated Membrane Protein 2; Lysosomes; Microtubule-Associated Proteins; Mutant Proteins; Neuroblastoma; Oxidants; Oxygen; Reactive Oxygen Species; RNA, Small Interfering; Transfection; Tretinoin; Tumor Cells, Cultured; Vacuoles | 2011 |
Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction.
Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cerebral Infarction; Gene Knockdown Techniques; Lysosomes; Male; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Thalamus; Vacuoles | 2012 |
Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cells, Cultured; Disease Models, Animal; Glucose; Infarction, Middle Cerebral Artery; Mice; Neurons; Neuroprotective Agents; Nicotinamide Phosphoribosyltransferase; Oxygen; Phagosomes; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Sirtuin 1; Stress, Physiological; Stroke; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2012 |
Inhibition of glutamine-dependent autophagy increases t-PA production in CHO cell fed-batch processes.
Topics: Adenine; Animals; Autophagy; CHO Cells; Cricetinae; Cricetulus; Culture Media, Serum-Free; Gene Expression Profiling; Glutamine; Recombinant Proteins; Tissue Plasminogen Activator | 2012 |
Autophagy regulates inflammation in adipocytes.
Topics: 3T3-L1 Cells; Adenine; Adipocytes; Animals; Autophagy; Endoplasmic Reticulum Stress; Gene Expression Regulation; Green Fluorescent Proteins; Inflammation; Insulin Resistance; Mice; Mice, Transgenic; Microtubule-Associated Proteins | 2012 |
Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells.
Topics: Adenine; Animals; Antigen Presentation; Antigen-Presenting Cells; Autophagy-Related Protein 5; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Citrulline; Gene Expression Regulation; Humans; Lymphoma, B-Cell; Mice; Microtubule-Associated Proteins; Peptides; Receptors, Antigen, B-Cell | 2011 |
Inhibition of rapamycin-induced autophagy causes necrotic cell death associated with Bax/Bad mitochondrial translocation.
Topics: Adenine; Animals; Autophagy; bcl-2-Associated X Protein; Caspase 3; Cell Death; Mitochondria; Necrosis; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus | 2012 |
Autophagy is a cell death mechanism in Toxoplasma gondii.
Topics: Adenine; Amino Acids; Animals; Autophagy; Cell Survival; Chlorocebus aethiops; Culture Media; Energy Metabolism; Host-Parasite Interactions; Humans; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Mitochondria; Prokaryotic Initiation Factor-2; Protein Biosynthesis; Signal Transduction; Sirolimus; Stress, Physiological; Toxoplasma; Vero Cells | 2012 |
Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Survival; Female; Gene Knockdown Techniques; Liver Neoplasms, Experimental; Melatonin; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Autophagy inhibited Ehrlich ascitic tumor cells apoptosis induced by the nitrostyrene derivative compounds: relationship with cytosolic calcium mobilization.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Calcium; Carcinoma, Ehrlich Tumor; Caspase 3; Cell Line, Tumor; Cytochromes c; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Nitro Compounds; Styrenes | 2012 |
Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Carbon Tetrachloride; Cell Line; Energy Metabolism; Epoxy Compounds; Fibroblasts; Hepatic Stellate Cells; Humans; Idiopathic Pulmonary Fibrosis; Kidney; Lipid Metabolism; Liver; Liver Cirrhosis, Experimental; Lung; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; Oleic Acid; RNA Interference; Thioacetamide | 2012 |
Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Cell Differentiation; Embryo, Mammalian; Embryonic Stem Cells; Haploinsufficiency; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microtubule-Associated Proteins; Neural Stem Cells; Neurites; Neurogenesis; Olfactory Bulb; Pyruvates; Spheroids, Cellular | 2012 |
Cross talk between NADPH oxidase and autophagy in pulmonary artery endothelial cells with intrauterine persistent pulmonary hypertension.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Cells, Cultured; Chloroquine; Endothelial Cells; Endothelium, Vascular; Green Fluorescent Proteins; Hypertension, Pulmonary; Microtubule-Associated Proteins; NADPH Oxidases; Neovascularization, Physiologic; Nuclear Proteins; Pulmonary Artery; Reactive Oxygen Species; Receptors, Immunologic; Recombinant Fusion Proteins; Sheep | 2012 |
Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cells.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Class III Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Microtubule-Associated Proteins | 2012 |
PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiation.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; Carboxylic Ester Hydrolases; Cell Line; Forkhead Box Protein O1; Forkhead Transcription Factors; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Muscle Development; Muscle, Skeletal; Myoblasts; Phosphoproteins; Phosphorylation; RNA Interference; RNA, Small Interfering; Transforming Growth Factor beta1 | 2012 |
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.
Topics: Adenine; Alkylating Agents; Alkylation; Carcinogens; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Methylation; Methylnitrosourea | 1980 |
Degradation of mouse NTE-related esterase by macroautophagy and the proteasome.
Topics: Adenine; Animals; Autophagy; Carboxylic Ester Hydrolases; Cycloheximide; Green Fluorescent Proteins; HEK293 Cells; Humans; Leupeptins; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Structure, Tertiary; Proteolysis; Recombinant Fusion Proteins | 2012 |
H1-antihistamines induce vacuolation in astrocytes through macroautophagy.
Topics: Adenine; Animals; Astrocytes; Autophagy; Central Nervous System; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Immunohistochemistry; Macrolides; Mice; Mice, Knockout; Vacuolar Proton-Translocating ATPases; Vacuoles | 2012 |
Tgf-β1 induces autophagy and promotes apoptosis in renal tubular epithelial cells.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Line; Epithelial Cells; Gene Expression Regulation; Humans; Kidney Tubules; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; NADPH Oxidases; Oxidative Stress; Reactive Oxygen Species; Transforming Growth Factor beta1; Ubiquitin-Activating Enzymes | 2012 |
Effect of γ34.5 deletions on oncolytic herpes simplex virus activity in brain tumors.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Neoplasms; Cell Line; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Disease Models, Animal; Eukaryotic Initiation Factor-2; Female; Gene Deletion; Gene Order; Gene Silencing; Humans; Mice; Mice, Nude; Mutation; Oncolytic Virotherapy; Oncolytic Viruses; Phosphorylation; RNA, Small Interfering; Survival Analysis; Viral Proteins; Virus Replication | 2012 |
Autophagy regulates endoplasmic reticulum stress in ischemic preconditioning.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 12; Caspase 3; Cells, Cultured; Cerebral Cortex; Cinnamates; Cytoprotection; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glucose; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Ischemic Preconditioning; Male; Mice; Neurons; Oxygen; Rats; Rats, Sprague-Dawley; Sirolimus; Thiourea; Transcription Factor CHOP | 2012 |
Autophagy favors Brucella melitensis survival in infected macrophages.
Topics: Adenine; Animals; Autophagy; Brucella melitensis; Brucellosis; Cell Line; Macrophages; Mice; Microtubule-Associated Proteins | 2012 |
HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Autophagy-Related Protein-1 Homolog; Autophagy-Related Proteins; Beclin-1; CD4-Positive T-Lymphocytes; Cysteine Endopeptidases; Gene Expression Regulation; HIV Infections; HIV-1; HIV-2; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Membrane Proteins; Microtubule-Associated Proteins; Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Virus Replication | 2012 |
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cisplatin; Fluorouracil; Humans; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation | 2012 |
Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures.
Topics: Adenine; Adjuvants, Immunologic; Aldehydes; Analysis of Variance; Animals; Asparagine; Autophagy; Brain; Cell Count; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; L-Lactate Dehydrogenase; Lithium Chloride; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Mitochondria; Neurons; Phosphorylation; Serine; Sirolimus; Tetrazolium Salts; Thiazoles; Trimethyltin Compounds; Vacuoles | 2012 |
Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1.
Topics: Adenine; Autophagy; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cholesterol; Cyclodextrins; Embryonic Stem Cells; Fibroblasts; Green Fluorescent Proteins; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Membrane Glycoproteins; Microscopy, Confocal; Mitochondria; Mitochondrial Proteins; Neural Stem Cells; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2012 |
Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts.
Topics: Acetaldehyde; Adenine; Alcohol Dehydrogenase; Alcohol Drinking; Animals; Autophagy; bcl-X Protein; Biomarkers; Ethanol; Fluorescent Antibody Technique; Heart; Lysosomes; Mice; MicroRNAs; Microtubule-Associated Proteins; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Rats; Signal Transduction; Thapsigargin | 2012 |
Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo.
Topics: Adenine; Adenoviridae; Adenovirus E1A Proteins; Adjuvants, Immunologic; Animals; Autophagy; Cell Line, Tumor; Chloroquine; Fluorescent Antibody Technique; Genetic Vectors; Glioma; Humans; Mice; Mice, Nude; Oncolytic Viruses; Polymerase Chain Reaction; Signal Transduction | 2012 |
Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Death; Cells, Cultured; Cytoplasm; Dendrites; Disease Models, Animal; Glaucoma; Intraocular Pressure; Male; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Up-Regulation | 2012 |
A knockout of the Tsg101 gene leads to decreased expression of ErbB receptor tyrosine kinases and induction of autophagy prior to cell death.
Topics: Actins; Adenine; Animals; Apoptosis; Autophagy; Cathepsin D; Cell Cycle; Cell Death; DNA-Binding Proteins; Endosomal Sorting Complexes Required for Transport; ErbB Receptors; Fibroblasts; Gene Deletion; Gene Expression Regulation; Hydrogen-Ion Concentration; Lysosomes; Macrolides; MAP Kinase Signaling System; Mice; Mice, Knockout; Receptor, ErbB-2; Transcription Factors | 2012 |
Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury.
Topics: Adenine; Animals; Animals, Newborn; Autophagy; Autophagy-Related Protein 7; Cardiotonic Agents; Cell Death; Cell Survival; Cytoprotection; Ether-A-Go-Go Potassium Channels; Gene Knockdown Techniques; Glucose; Humans; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Myocytes, Cardiac; Phagosomes; Phosphorylation; Proteins; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin-Activating Enzymes | 2012 |
Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Boronic Acids; Bortezomib; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Membrane Proteins; Microtubule-Associated Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines | 2012 |
Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Disease Models, Animal; In Situ Nick-End Labeling; Male; Microscopy, Confocal; Microscopy, Electron, Transmission; Mitochondria; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sirolimus; Subarachnoid Hemorrhage | 2012 |
Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells.
Topics: Adenine; Androstadienes; Animals; Caspase 3; Cell Cycle Checkpoints; Cell Death; Cell Line; Cell Survival; Fibroblasts; HeLa Cells; Humans; Mice; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Wortmannin | 2012 |
Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 7; Cell Line; Chlorocebus aethiops; Chromones; Glycoproteins; HeLa Cells; Humans; Morpholines; Proteolysis; RNA Interference; RNA, Small Interfering; Sin Nombre virus; Ubiquitin-Activating Enzymes; Vero Cells; Viral Envelope Proteins; Virus Replication; Wortmannin | 2012 |
Gas-phase studies of purine 3-methyladenine DNA glycosylase II (AlkA) substrates.
Topics: Adenine; Catalytic Domain; DNA Glycosylases; Escherichia coli; Guanine; Protons; Purines; Stereoisomerism; Substrate Specificity; Temperature; Xanthine | 2012 |
Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition.
Topics: Acetylcysteine; Adenine; Anthracenes; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Death; Cell Line, Tumor; Humans; Male; MAP Kinase Signaling System; Membrane Proteins; Neoplasms, Hormone-Dependent; Neuregulins; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Recombinant Proteins; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-α-induced neutrophil apoptosis.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; Chloroquine; Down-Regulation; Humans; Myeloid Cell Leukemia Sequence 1 Protein; Neutrophils; Proto-Oncogene Proteins c-bcl-2; Quinolines; Tumor Necrosis Factor-alpha | 2012 |
A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus.
Topics: Adenine; Amino Acid Sequence; Base Sequence; DNA Glycosylases; Models, Molecular; Molecular Sequence Data; Protein Interaction Domains and Motifs; Staphylococcus aureus; Substrate Specificity | 2012 |
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma; Cell Line, Tumor; Drugs, Chinese Herbal; Extracellular Signal-Regulated MAP Kinases; Flavanones; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; raf Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
Effect of trehalose on PC12 cells overexpressing wild-type or A53T mutant α-synuclein.
Topics: Adenine; Alanine; alpha-Synuclein; Animals; Autophagy; Blotting, Western; Cell Survival; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Lysosomes; Microscopy, Electron, Transmission; PC12 Cells; Phagosomes; Phosphoinositide-3 Kinase Inhibitors; Point Mutation; Proteasome Inhibitors; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Threonine; Transduction, Genetic; Trehalose; Up-Regulation | 2012 |
The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes.
Topics: Acids; Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; Cell Proliferation; Cytoplasmic Vesicles; Cytoprotection; Dyneins; Interleukin-7; Intracellular Space; Lymphocytes; Lysosomes; Membrane Proteins; Mice; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins | 2012 |
Necrostatin-1 suppresses autophagy and apoptosis in mice traumatic brain injury model.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Brain Injuries; Caspase 3; Cell Death; Coloring Agents; Enzyme Activation; Imidazoles; Indoles; Injections, Intraventricular; Male; Mice; Microtubule-Associated Proteins; Oligopeptides; Propidium; Proto-Oncogene Proteins c-bcl-2 | 2012 |
Porcine reproductive and respiratory syndrome virus induces autophagy to promote virus replication.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Survival; Endocytosis; Gene Knockdown Techniques; Lysosomes; Membrane Fusion; Microtubule-Associated Proteins; Phagosomes; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; RNA Interference; Sirolimus; Swine; Viral Nonstructural Proteins; Virus Replication | 2012 |
The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.
Topics: Adenine; Adenosine; Animals; Autophagy; Cell Differentiation; Coxsackievirus Infections; Enterovirus B, Human; Fibroblast Growth Factors; Green Fluorescent Proteins; HeLa Cells; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neural Stem Cells; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Sirolimus; Transduction, Genetic; Viral Load; Viral Proteins; Virus Replication | 2012 |
Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells.
Topics: Acetylation; Adenine; Apoptosis; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Down-Regulation; Female; G1 Phase Cell Cycle Checkpoints; Histone Deacetylase Inhibitors; Humans; Microtubule-Associated Proteins; Naphthols; Sirtuins; Tumor Suppressor Protein p53; Up-Regulation | 2012 |
EGFR inhibitor BIBU induces apoptosis and defective autophagy in glioma cells.
Topics: Adenine; Apoptosis; Autophagy; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Central Nervous System Neoplasms; ErbB Receptors; Glioma; Humans; Interleukin-6; Membrane Microdomains; Microtubule-Associated Proteins; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; STAT3 Transcription Factor; TOR Serine-Threonine Kinases | 2013 |
Autophagy influences maternal mRNA degradation and apoptosis in porcine parthenotes developing in vitro.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Blastocyst; Cell Cycle Proteins; Ectogenesis; Female; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Meiosis; Microtubule-Associated Proteins; Oocytes; Parthenogenesis; RNA Stability; RNA, Messenger, Stored; Sirolimus; Sus scrofa; Transcription Factors | 2012 |
The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes.
Topics: 3T3-L1 Cells; Adenine; Adipocytes; Androstadienes; Animals; Autophagy; Hydrolysis; Lipase; Lipolysis; Mice; Phosphoinositide-3 Kinase Inhibitors; RNA, Small Interfering; Signal Transduction; Sterol Esterase; Triglycerides; Wortmannin | 2013 |
SD118-xanthocillin X (1), a novel marine agent extracted from Penicillium commune, induces autophagy through the inhibition of the MEK/ERK pathway.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Aquatic Organisms; Autophagy; Beclin-1; Biological Products; Butadienes; Cell Line, Tumor; Down-Regulation; Hep G2 Cells; Humans; MAP Kinase Signaling System; Membrane Proteins; Penicillium; Phenols; Phosphatidylinositol 3-Kinases; Signal Transduction; Up-Regulation | 2012 |
Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells, Cultured; Chalcones; Chloroquine; Gene Knockdown Techniques; HEK293 Cells; Humans; Macrolides; Membrane Potential, Mitochondrial; Membrane Proteins; Mitochondria; Multiple Myeloma; Protein Kinase C-delta; Proteolysis | 2012 |
Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues.
Topics: Adenine; Animals; Apoptosis; Biomimetics; Blood Vessels; Cattle; Cell Culture Techniques; Diffusion; Fluorescein-5-isothiocyanate; Glutathione; Hep G2 Cells; Humans; Microfluidic Analytical Techniques; Models, Biological; Quantum Dots; Reactive Oxygen Species; Serum Albumin, Bovine | 2012 |
Analysis of monensin sensitivity in Toxoplasma gondii reveals autophagy as a mechanism for drug induced death.
Topics: Adenine; Antiprotozoal Agents; Autophagy; DNA Repair Enzymes; Microtubule-Associated Proteins; Mitochondria; Monensin; S Phase Cell Cycle Checkpoints; Toxoplasma | 2012 |
RNase L triggers autophagy in response to viral infections.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cells, Cultured; Chlorocebus aethiops; Encephalomyocarditis virus; Endoribonucleases; Heat-Shock Proteins; HeLa Cells; Humans; Macrolides; Mice; Mice, Inbred C57BL; Mice, Knockout; Microtubule-Associated Proteins; RNA Interference; RNA, Small Interfering; Sequestosome-1 Protein; Vesicular stomatitis Indiana virus; Virus Replication | 2012 |
Oxidative stress impairs autophagic flux in prion protein-deficient hippocampal cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspases; Enzyme Activation; Gene Knockdown Techniques; Hippocampus; Hydrogen Peroxide; Mice; Models, Biological; Neurons; Oxidative Stress; Prions; Protective Agents; Sirolimus; Time Factors; Trehalose | 2012 |
Neem oil limonoids induces p53-independent apoptosis and autophagy.
Topics: Adenine; Apoptosis; Apoptosis Inducing Factor; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Fluorescent Antibody Technique; Glycerides; Humans; Insecticides; Limonins; Membrane Proteins; Mitochondria; Terpenes; Tumor Suppressor Protein p53 | 2012 |
Autophagy modulators sensitize prostate epithelial cancer cell lines to TNF-alpha-dependent apoptosis.
Topics: Adenine; Apoptosis; Autophagy; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Epithelial Cells; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Male; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Sirolimus; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2012 |
Nifedipine induced autophagy through Beclin1 and mTOR pathway in endometrial carcinoma cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line, Tumor; Endometrial Neoplasms; Female; Humans; Membrane Proteins; Nifedipine; Signal Transduction; TOR Serine-Threonine Kinases | 2012 |
β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.
Topics: Adenine; Apoptosis; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Chloroquine; Extracellular Signal-Regulated MAP Kinases; Humans; Kidney Neoplasms; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Sesquiterpenes; TOR Serine-Threonine Kinases | 2012 |
In vivo and in vitro Leishmania amazonensis infection induces autophagy in macrophages.
Topics: Adenine; Amines; Animals; Autophagy; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Female; Leishmania mexicana; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microtubule-Associated Proteins; Sirolimus; Staining and Labeling | 2012 |
Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine.
Topics: Adenine; Antineoplastic Agents; Autophagy; Benzophenanthridines; Caspases; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Melanoma; Microtubule-Associated Proteins; Necrosis; Proto-Oncogene Proteins c-bcl-2 | 2012 |
[Role of autophagy in quercetin-induced apoptosis in human bladder carcinoma BIU-87 cells].
Topics: Adenine; Antioxidants; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Quercetin; Urinary Bladder Neoplasms | 2012 |
Regulation of inflammatory response by 3-methyladenine involves the coordinative actions on Akt and glycogen synthase kinase 3β rather than autophagy.
Topics: Adenine; Animals; Autophagy; Cell Line; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Inflammation Mediators; Lipopolysaccharides; Macrophages; Mice; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Signal Transduction; Up-Regulation | 2012 |
Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Line, Transformed; Cells, Cultured; Female; Immunity, Innate; Inflammation Mediators; Interleukin-1alpha; Interleukin-1beta; Interleukin-23; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocyte Subsets; Up-Regulation | 2012 |
New ruthenium(II)-letrozole complexes as anticancer therapeutics.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Aromatase Inhibitors; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Curcumin; Drug Interactions; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Letrozole; Nitriles; Ruthenium; Stereoisomerism; Structure-Activity Relationship; Triazoles | 2012 |
Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Brain Ischemia; Immunosuppressive Agents; Ischemic Postconditioning; Male; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Sirolimus; Up-Regulation | 2012 |
Direct-acting DNA alkylating agents present in aqueous extracts of areca nut and its products.
Topics: Adenine; Alkylation; Animals; Areca; Cattle; Chromatography, Liquid; DNA; DNA Damage; Guanine; Molecular Structure; Nuts; Plant Extracts; Tandem Mass Spectrometry; Water | 2012 |
Early otic development depends on autophagy for apoptotic cell clearance and neural differentiation.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Chickens; Ear, Inner; Embryo, Nonmammalian; Microtubule-Associated Proteins; Morpholinos; Neuroepithelial Cells; Neurogenesis; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Transcription, Genetic | 2012 |
3,4-Dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells.
Topics: Adenine; AMP-Activated Protein Kinases; Angiogenesis Inhibitors; Apoptosis; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Calcium; Caspase 3; Caspase 9; Cell Line; Cell Movement; Cell Proliferation; Cell Survival; Cytochromes c; Human Umbilical Vein Endothelial Cells; Humans; Microtubule-Associated Proteins; Neovascularization, Physiologic; Reactive Oxygen Species; Resveratrol; RNA Interference; RNA, Small Interfering; Stilbenes; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2013 |
Inhibition of autophagy enhances apoptosis induced by the PI3K/AKT/mTor inhibitor NVP-BEZ235 in renal cell carcinoma cells.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Chloroquine; Drug Synergism; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Kidney Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Proteotoxic stress induced by Autographa californica nucleopolyhedrovirus infection of Spodoptera frugiperda Sf9 cells.
Topics: Acetylcysteine; Adenine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA Replication; DNA, Viral; HSC70 Heat-Shock Proteins; Lysosomes; Moths; Nucleopolyhedroviruses; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sf9 Cells; Spodoptera; Ubiquitinated Proteins; Ubiquitination; Virus Replication | 2013 |
Evodiamine activates autophagy as a cytoprotective response in murine Lewis lung carcinoma cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Carcinoma, Lewis Lung; Caspases; Cell Line, Tumor; Cell Proliferation; Gene Expression; Mice; Microtubule-Associated Proteins; Quinazolines; Up-Regulation | 2013 |
Tetracycline inhibits local inflammation induced by cerebral ischemia via modulating autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Inflammation; Interleukin-6; Male; Microglia; Microtubule-Associated Proteins; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetracycline; Tumor Necrosis Factor-alpha | 2012 |
Allorecognition triggers autophagy and subsequent necrosis in the cnidarian Hydractinia symbiolongicarpus.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cnidaria; In Situ Nick-End Labeling; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Models, Biological; Necrosis; Sirolimus | 2012 |
Rapamycin and 3-methyladenine regulate apoptosis and autophagy in bone-derived endothelial progenitor cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Cycle; Cell Proliferation; Cells, Cultured; Rats; Sirolimus | 2012 |
[The effect of autophagy on the radioresistance of human adenocarcinoma A549 cell in hypoxia condition].
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Autophagy; Cell Hypoxia; Cell Line, Tumor; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Microtubule-Associated Proteins; Radiation Tolerance | 2012 |
Participation of autophagy in lung ischemia-reperfusion injury in vivo.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Female; Lung; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2013 |
Synthesis and characterization of DNA minor groove binding alkylating agents.
Topics: Adenine; Alkylating Agents; Animals; Cattle; Cell Line, Tumor; Cell Survival; DNA; DNA Breaks, Double-Stranded; DNA Glycosylases; DNA Methylation; Escherichia coli; Escherichia coli Proteins; Humans; Peptides; Poly(ADP-ribose) Polymerases; Thermodynamics | 2013 |
Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Autophagy; Cell Line, Tumor; Enzyme Activation; Furans; Humans; Pancreatic Neoplasms; Pyrimidines; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2013 |
Restoration of klotho expression induces apoptosis and autophagy in hepatocellular carcinoma cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Apoptosis; Autophagy; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glucuronidase; Hep G2 Cells; Humans; Klotho Proteins; Liver Neoplasms; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Transfection | 2013 |
Human papillomavirus infection is inhibited by host autophagy in primary human keratinocytes.
Topics: Adenine; Autophagy; Autophagy-Related Protein 7; Capsid Proteins; Cell Line; Cells, Cultured; HEK293 Cells; Human papillomavirus 16; Humans; Keratinocytes; Phosphatidylinositol 3-Kinases; RNA Interference; RNA, Small Interfering; Ubiquitin-Activating Enzymes; Virus Internalization | 2013 |
Rapamycin induces apoptosis when autophagy is inhibited in T-47D mammary cells and both processes are regulated by Phlda1.
Topics: Adenine; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Humans; Oligonucleotide Array Sequence Analysis; Sirolimus; Transcription Factors; Up-Regulation | 2013 |
Porphyromonas gingivalis strain specific interactions with human coronary artery endothelial cells: a comparative study.
Topics: Adenine; Atherosclerosis; Bacterial Adhesion; Cell Survival; Cells, Cultured; Coronary Vessels; E-Selectin; Endothelial Cells; Host-Pathogen Interactions; Humans; Lysosomal Membrane Proteins; Microbial Viability; Microtubule-Associated Proteins; Phagocytosis; Porphyromonas gingivalis; Species Specificity; Vacuoles | 2012 |
[Mechanism of radiosensitization of 3-methyladenine in human hypopharynx cancer cells].
Topics: Adaptor Proteins, Signal Transducing; Adenine; Cell Cycle; Cell Line, Tumor; Cyclin B1; DNA Damage; Humans; Radiation Tolerance; Radiation-Sensitizing Agents; Sequestosome-1 Protein | 2012 |
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Humans; Indoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyridazines; Pyrimidines; Stomach Neoplasms; Sulfones; Ubiquitin-Activating Enzymes | 2013 |
Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy.
Topics: Adenine; Androstanes; Aromatase Inhibitors; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Estrogen Antagonists; Female; Humans; MCF-7 Cells; Neoplasms, Hormone-Dependent; Phosphatidylinositol 3-Kinases; Receptors, Estrogen; Testosterone | 2013 |
Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy.
Topics: Adenine; alpha-Synuclein; Autophagy; Blotting, Western; Cell Line; Cell Survival; Curcumin; Genetic Vectors; Humans; Immunohistochemistry; Macrophages; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases; Transfection | 2013 |
Autophagy regulates chlorpyrifos-induced apoptosis in SH-SY5Y cells.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Apoptosis; Autophagy; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Survival; Chlorpyrifos; Humans; Insecticides; Microtubule-Associated Proteins; Neurotoxicity Syndromes; Proto-Oncogene Proteins c-bcl-2; Sequestosome-1 Protein; Sirolimus; Up-Regulation | 2013 |
Mitochondrial aldehyde dehydrogenase obliterates endoplasmic reticulum stress-induced cardiac contractile dysfunction via correction of autophagy.
Topics: Adenine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Arrhythmias, Cardiac; Autophagy; Brugada Syndrome; Calcium; Cardiac Conduction System Disease; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heart Conduction System; Humans; Mice; Mice, Transgenic; Mitochondria; Myocardial Contraction; Myocytes, Cardiac; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2013 |
AKT serine/threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T24 cells.
Topics: Acridine Orange; Adenine; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Cadaverine; Caspase 3; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Flavonoids; Humans; Medicine, Chinese Traditional; Membrane Proteins; Microtubule-Associated Proteins; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Transglutaminases; Ubiquitin-Activating Enzymes; Urinary Bladder Neoplasms | 2013 |
[The influence of induced autophagy in vitro on proliferation of multiple myeloma cells].
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Multiple Myeloma; Sirolimus | 2012 |
Phosphate-induced autophagy counteracts vascular calcification by reducing matrix vesicle release.
Topics: Adenine; Alkaline Phosphatase; Amino Acid Chloromethyl Ketones; Animals; Antioxidants; Autophagy; Autophagy-Related Protein 5; Caspase Inhibitors; Cattle; Cells, Cultured; Disease Models, Animal; Kidney Failure, Chronic; Metalloporphyrins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphates; Proteins; Rats; RNA Interference; Secretory Vesicles; Sodium-Phosphate Cotransporter Proteins, Type III; Superoxide Dismutase; Time Factors; Transfection; Valproic Acid; Vascular Calcification | 2013 |
Activation of autophagy in ischemic postconditioning contributes to cardioprotective effects against ischemia/reperfusion injury in rat hearts.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; DNA Primers; Gene Expression; Heart; Hemodynamics; Ischemic Postconditioning; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Myocardial Infarction; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction | 2013 |
Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells.
Topics: Adenine; Autophagy; Caco-2 Cells; Coated Pits, Cell-Membrane; Endocytosis; Ferritins; Humans; Intestinal Mucosa; Iron; Lysosomes; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Vesicular Transport Proteins | 2013 |
Differential autophagic cell death under stress with ectopic cytoplasmic and mitochondrial-specific PPP2R2B in human neuroblastoma cells.
Topics: Adenine; Autophagy; Cell Line, Tumor; Clone Cells; Cytosol; Endoplasmic Reticulum Stress; Gene Expression Regulation; Humans; Isoenzymes; Macrolides; Membrane Potential, Mitochondrial; Mitochondria; Nerve Tissue Proteins; Neurons; Protein Phosphatase 2; Reactive Oxygen Species; Signal Transduction; Stress, Physiological; Transfection; Tunicamycin | 2013 |
High glucose induces autophagy in podocytes.
Topics: Acetylcysteine; Adenine; Animals; Antioxidants; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blood Glucose; Catalase; Culture Media; Diabetes Mellitus, Experimental; Glucose; Male; Microscopy, Electron; Microtubule-Associated Proteins; Podocytes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirolimus; Streptozocin; Superoxide Dismutase; Tumor Cells, Cultured | 2013 |
Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β).
Topics: Adenine; Androstadienes; Autophagy; Borrelia burgdorferi; Caspase 1; Cells, Cultured; Enzyme Activation; Host-Pathogen Interactions; Humans; Inflammation Mediators; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Reactive Oxygen Species; Receptors, Interleukin-1; Tumor Necrosis Factor-alpha; Wortmannin | 2013 |
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy.
Topics: Adenine; Antineoplastic Agents; Autophagy; Cisplatin; Drug Agonism; Drug Synergism; Fluorouracil; HeLa Cells; Humans; MCF-7 Cells; Microtubule-Associated Proteins; Tamoxifen | 2013 |
Protective role of autophagy in matrine‑induced gastric cancer cell death.
Topics: Adenine; Alkaloids; Apoptosis; Autophagy; Cell Line, Tumor; Cell Nucleus; Cell Shape; Cell Survival; Drug Synergism; Humans; Immunoglobulin G; Macrolides; Matrines; Melphalan; Microtubule-Associated Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinolizines; Stomach Neoplasms | 2013 |
Synthesis and screening of 3-MA derivatives for autophagy inhibitors.
Topics: Adenine; Adenosine Triphosphate; Animals; Autophagy; Cell Line; Cell Survival; Drug Evaluation, Preclinical; Endocytosis; Green Fluorescent Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Rats; Small Molecule Libraries | 2013 |
Increased expression of Beclin-1-dependent autophagy protects against beta-amyloid-induced cell injury in PC12 cells [corrected].
Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Neurons; PC12 Cells; Peptide Fragments; Phosphopyruvate Hydratase; Rats; Sirolimus; Up-Regulation | 2013 |
PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress.
Topics: Actins; Adenine; Aldehydes; Animals; Aorta; Autophagy; Biomarkers; Calcium-Binding Proteins; Calponins; Gene Expression Regulation; Macrolides; Male; Microfilament Proteins; Microtubule-Associated Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Osteopontin; Oxidative Stress; Phenotype; Platelet-Derived Growth Factor; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Signal Transduction; Vimentin | 2013 |
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy.
Topics: Adenine; Animals; Autophagy; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cells, Cultured; Hypoxia; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Male; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neuroprotective Agents; Prosencephalon; Proteins; Rats; Rats, Wistar; RNA Interference; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2013 |
Cisplatin-induced apoptosis inhibits autophagy, which acts as a pro-survival mechanism in human melanoma cells.
Topics: Adaptor Proteins, Vesicular Transport; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Beclin-1; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Cisplatin; Cysteine Proteinase Inhibitors; Dipeptides; Feedback, Physiological; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Membrane Proteins; Microtubule-Associated Proteins; Signal Transduction; Trehalose | 2013 |
Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzamides; Cell Line, Tumor; Down-Regulation; Fusion Proteins, bcr-abl; Gene Knockdown Techniques; Humans; Imatinib Mesylate; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Proteins; Mice; Phagosomes; Piperazines; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Pyrimidines; RNA, Small Interfering; Signal Transduction; Transfection | 2013 |
Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Shape; Cell Survival; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Energy Metabolism; Enzyme Activation; Epidermal Growth Factor; Humans; Macrolides; Metabolomics; Mice; Mitogens; Models, Biological; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Silybin; Silymarin; Somatomedins; TOR Serine-Threonine Kinases; Vacuoles | 2013 |
Vitamin D-dependent cathelicidin inhibits Mycobacterium marinum infection in human monocytic cells.
Topics: Adenine; Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Autophagy; Autophagy-Related Protein 5; Calcitriol; Cathelicidins; Cell Line, Tumor; Chloroquine; Cytokines; Fibroblasts; Humans; Mice, Knockout; Microtubule-Associated Proteins; Monocytes; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Receptors, Calcitriol; RNA Interference; Time Factors; Transfection; Up-Regulation | 2013 |
Decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma.
Topics: Adenine; Antibiotics, Antineoplastic; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Humans; Male; Membrane Proteins; Microtubule-Associated Proteins; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Phagosomes; Sirolimus; Tongue Neoplasms | 2013 |
Intermittent-hypoxia induced autophagy attenuates contractile dysfunction and myocardial injury in rat heart.
Topics: Adenine; Animals; Autophagy; Chloroquine; Heart Diseases; Heart Failure; Hypoxia; Lysosomes; Male; Muscle Contraction; Myocardium; Myocytes, Cardiac; Necrosis; Phagosomes; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases; Troponin T | 2013 |
Suppression of autophagy by CUB domain-containing protein 1 signaling is essential for anchorage-independent survival of lung cancer cells.
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Anoikis; Antigens, CD; Antigens, Neoplasm; Autophagy; Caspase 3; Cell Adhesion Molecules; Cell Death; Cell Line, Tumor; Humans; Lung Neoplasms; Microtubule-Associated Proteins; Neoplasm Proteins; Phagosomes; Phosphorylation; Protein Kinase C-delta; Proto-Oncogene Proteins c-fyn; RNA, Small Interfering; Signal Transduction; src-Family Kinases | 2013 |
Autophagy is involved in endoplasmic reticulum stress-induced cell death of rat hepatocytes.
Topics: Adenine; Androstadienes; Animals; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Fatty Liver; Hepatocytes; Male; Rats; Rats, Zucker; Taurochenodeoxycholic Acid; Tunicamycin; Wortmannin | 2013 |
The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice.
Topics: Adenine; Animals; Autophagy; Blood-Brain Barrier; Cerebral Cortex; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; NF-kappa B; NF-kappa B p50 Subunit; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Cytoprotective role of autophagy during paclitaxel-induced apoptosis in Saos-2 osteosarcoma cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Bone Neoplasms; Caspase 3; Cell Death; Cell Line, Tumor; Cytochromes c; Cytoprotection; Humans; Membrane Potential, Mitochondrial; Mitochondria; Osteosarcoma; Paclitaxel; X-Linked Inhibitor of Apoptosis Protein | 2013 |
Autophagy contributes to leaf starch degradation.
Topics: Adenine; Arabidopsis; Autophagy; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Silencing; Hydrolysis; Luminescent Proteins; Microscopy, Confocal; Microscopy, Electron, Transmission; Molecular Sequence Data; Mutation; Nicotiana; Phagosomes; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Seedlings; Starch | 2013 |
Dual PI3K/mTOR inhibitor NVP-BEZ235-induced apoptosis of hepatocellular carcinoma cell lines is enhanced by inhibitors of autophagy.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Liver Neoplasms; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolines; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Inhibition of autophagy enhances cisplatin cytotoxicity in human adenoid cystic carcinoma cells of salivary glands.
Topics: Adenine; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Cell Culture Techniques; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Cisplatin; Coloring Agents; Drug Resistance, Neoplasm; Green Fluorescent Proteins; Humans; Luminescent Agents; Membrane Proteins; Microtubule-Associated Proteins; Salivary Gland Neoplasms; Tetrazolium Salts; Thiazoles | 2013 |
Attenuating heat-induced cellular autophagy, apoptosis and damage in H9c2 cardiomyocytes by pre-inducing HSP70 with heat shock preconditioning.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase Inhibitors; Cell Line; Cell Survival; Diterpenes; Epoxy Compounds; Heat-Shock Response; Hot Temperature; HSP70 Heat-Shock Proteins; Myocytes, Cardiac; Oligopeptides; Phenanthrenes; Rats | 2013 |
Combination of FTY720 with cisplatin exhibits antagonistic effects in ovarian cancer cells: role of autophagy.
Topics: Adenine; Antineoplastic Agents; Autophagy; Cell Count; Cell Death; Cell Line, Tumor; Cisplatin; Drug Antagonism; Drug Resistance, Neoplasm; Female; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Ovarian Neoplasms; Propylene Glycols; RNA, Small Interfering; Sphingosine | 2013 |
Cell death control: the interplay of apoptosis and autophagy in the pathogenicity of Sclerotinia sclerotiorum.
Topics: Adenine; Androstadienes; Antifungal Agents; Apoptosis; Arabidopsis; Ascomycota; Autophagy; Chloroquine; Chromones; Host-Pathogen Interactions; Morpholines; Mycoses; Oxalic Acid; Plant Diseases; Reactive Oxygen Species; Respiratory Burst; Wortmannin | 2013 |
Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Diabetic Nephropathies; Endoplasmic Reticulum; Hyperglycemia; Mice; Podocytes; RNA, Small Interfering; Taurochenodeoxycholic Acid | 2013 |
Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein.
Topics: Adenine; alpha-Synuclein; Animals; Autophagy; Cell Survival; Chymotrypsin; Humans; Oligopeptides; Parkinson Disease; PC12 Cells; Point Mutation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Rats | 2013 |
Harnessing autophagy for cell fate control gene therapy.
Topics: Adenine; Animals; Antigens, CD19; Apoptosis; Autophagy; CD4-Positive T-Lymphocytes; Cell Lineage; Cell Proliferation; Cell Survival; Genetic Therapy; Humans; Lentivirus; Mice; Nucleoside-Phosphate Kinase; Phenotype; Sirolimus; Transduction, Genetic; Transgenes; Zidovudine | 2013 |
Arylpiperazine-mediated activation of Akt protects SH-SY5Y neuroblastoma cells from 6-hydroxydopamine-induced apoptotic and autophagic death.
Topics: Adenine; Adrenergic Agents; Analysis of Variance; Apoptosis; Autophagy; Cell Survival; Cytoplasm; Dose-Response Relationship, Drug; Drug Interactions; Humans; Macrolides; Neuroblastoma; Neuroprotective Agents; Oxidopamine; Piperazines; Proto-Oncogene Proteins c-akt; Pyridines; RNA, Small Interfering; Signal Transduction; Superoxides; Time Factors | 2013 |
Autophagic failure promotes the exocytosis and intercellular transfer of α-synuclein.
Topics: Adenine; alpha-Synuclein; Animals; Autophagy; Autophagy-Related Protein 7; Cell Line; Exocytosis; Extracellular Space; Humans; Mice; Mice, Knockout; Microtubule-Associated Proteins; Phagosomes; Protein Structure, Quaternary; Protein Transport | 2013 |
[Effects of autophagy modulator on autophagy and uridine 5'-diphospho-glucuronosyltransferase 1A1 induced by sulforaphane].
Topics: Adenine; Autophagy; Caco-2 Cells; Glucuronosyltransferase; Humans; Isothiocyanates; Sirolimus; Sulfoxides | 2013 |
Dual inhibition of autophagy and the AKT pathway in prostate cancer.
Topics: Adenine; Autophagy; Cell Line, Tumor; Chloroquine; Clinical Trials, Phase I as Topic; Humans; Macrolides; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Signal Transduction | 2013 |
BECN1 and BIM interactions with MCL-1 determine fludarabine resistance in leukemic B cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Bcl-2-Like Protein 11; Beclin-1; Cell Line, Tumor; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lysosomal-Associated Membrane Protein 2; Membrane Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Ubiquitin-Activating Enzymes; Vidarabine | 2013 |
Adenosine monophosphate-activated protein kinase/mammalian target of rapamycin-dependent autophagy protects human dental pulp cells against hypoxia.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Beclin-1; Cell Culture Techniques; Cell Hypoxia; Cell Survival; Cells, Cultured; Dental Pulp; Genetic Vectors; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1; Indazoles; Membrane Proteins; Microtubule-Associated Proteins; Plasmids; Proto-Oncogene Proteins; Small Ubiquitin-Related Modifier Proteins; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2013 |
Autophagy inhibition rescues against leptin-induced cardiac contractile dysfunction.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Calcium Signaling; Cardiotonic Agents; Cell Line; Cells, Cultured; Down-Regulation; Enzyme Activation; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Contraction; Myocytes, Cardiac; Phagosomes; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Reactive Oxygen Species | 2014 |
Upregulation of myeloid cell leukemia-1 potentially modulates beclin-1-dependent autophagy in ischemic stroke in rats.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain; Disease Models, Animal; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Time Factors; Up-Regulation | 2013 |
Autophagy induced by the withdrawal of mitogens promotes neurite extension in rat neural stem cells.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Axons; Beclin-1; Cells, Cultured; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Mitogens; Neural Stem Cells; Neurites; Neurodegenerative Diseases; Rats; Rats, Wistar | 2013 |
Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells.
Topics: Adenine; Adenosine Triphosphate; Adenoviridae; Adenoviridae Infections; Antineoplastic Agents; Apoptosis; Autophagy; Cell Death; Cell Line, Tumor; Cell Survival; HEK293 Cells; HeLa Cells; Humans; Oncolytic Virotherapy; Oncolytic Viruses; Sarcoma; Telomerase | 2013 |
Amyloid β peptides promote autophagy-dependent differentiation of mouse neural stem cells: Aβ-mediated neural differentiation.
Topics: Adenine; Amyloid beta-Peptides; Animals; Astrocytes; Autophagy; Biomarkers; Cell Differentiation; Cell Line; Cell Lineage; Cell Proliferation; Cell Separation; Fetus; Mice; Neural Stem Cells; Neurons; Prosencephalon; S Phase | 2013 |
Pharmacological activation of Sirt1 ameliorates polyglutamine-induced toxicity through the regulation of autophagy.
Topics: Adenine; Animals; Animals, Genetically Modified; Apoptosis; Autophagy; Blotting, Western; Caenorhabditis elegans; Cell Movement; Cell Proliferation; Green Fluorescent Proteins; Humans; Huntingtin Protein; Immunoenzyme Techniques; Immunoprecipitation; Microscopy, Fluorescence; Naphthoquinones; Nerve Tissue Proteins; Neuroblastoma; Peptides; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Sirtuin 1 | 2013 |
Effective NET formation in neutrophils from individuals with G6PD Taiwan-Hakka is associated with enhanced NADP(+) biosynthesis.
Topics: Adenine; Autophagy; Glucosephosphate Dehydrogenase; Humans; NADP; NADPH Oxidases; Neutrophils; Onium Compounds; Oxidative Stress; Reactive Oxygen Species; Tetradecanoylphorbol Acetate | 2013 |
Autophagy stimulates apoptosis in HER2-overexpressing breast cancers treated by lapatinib.
Topics: Adenine; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-2; Signal Transduction | 2013 |
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity.
Topics: Actins; Adenine; Antimetabolites, Antineoplastic; Antineoplastic Agents; Areca; Autophagy; Autophagy-Related Proteins; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Chloroquine; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Fluorouracil; Glucose; Humans; Indicators and Reagents; Jurkat Cells; Microtubule-Associated Proteins; Mouth Neoplasms; Plant Extracts; Tetrazolium Salts; Time Factors | 2014 |
Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Brain Ischemia; Cytochromes c; Cytoprotection; Glucose; Hypoxia; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; Mitophagy; Neurons; Quinazolinones; Rats; Reperfusion Injury; Ubiquitin-Protein Ligases | 2013 |
Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Cell Line, Transformed; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Green Fluorescent Proteins; Heat-Shock Proteins; HSP20 Heat-Shock Proteins; Humans; Leupeptins; Mice; Molecular Chaperones; Motor Neurons; Muscle Proteins; Mutation; Receptors, Androgen; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Testosterone; Trehalose | 2013 |
Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells.
Topics: Abietanes; Adenine; AMP-Activated Protein Kinases; Autophagy; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Humans; Leukemia; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases | 2014 |
Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Calcium-Binding Proteins; Calponins; Cell Proliferation; Cells, Cultured; Coronary Vessels; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lysosomes; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microtubule-Associated Proteins; Muscle Cells; Phenotype; rac1 GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction; Simvastatin; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
3-MA inhibits autophagy and favors long-term integration of grafted Gad67-GFP GABAergic precursors in the developing neocortex by preventing apoptosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Differentiation; Cell Survival; Cell Transplantation; Embryonic Stem Cells; Female; GABAergic Neurons; Glutamate Decarboxylase; Green Fluorescent Proteins; Interneurons; Male; Mice; Mice, Transgenic; Neocortex; Neural Stem Cells; Pregnancy; Recombinant Fusion Proteins; Sirolimus | 2014 |
Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Line; Eicosapentaenoic Acid; Hydrogen Peroxide; Myoblasts; Myocardium; Myocytes, Cardiac; Organelles; Oxidative Stress; Phosphorylation; Rats | 2014 |
Autophagy induced by cathepsin S inhibition induces early ROS production, oxidative DNA damage, and cell death via xanthine oxidase.
Topics: Adenine; Androstadienes; Antigen Presentation; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cathepsins; Cell Line, Tumor; Cell Survival; DNA Damage; Humans; Microtubule-Associated Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Ubiquitin-Activating Enzymes; Wortmannin; Xanthine Oxidase | 2013 |
Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain Ischemia; Caspase 3; Cerebrum; Immunosuppressive Agents; In Situ Nick-End Labeling; Ischemic Preconditioning; Male; Nerve Degeneration; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins | 2013 |
A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Survival; Colonic Neoplasms; Enzyme Activation; Ginsenosides; HCT116 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Ubiquitin-Activating Enzymes; Up-Regulation | 2013 |
Activation of autophagy rescues amiodarone-induced apoptosis of lung epithelial cells and pulmonary toxicity in rats.
Topics: Adenine; Administration, Inhalation; Amiodarone; Animals; Anti-Arrhythmia Agents; Apoptosis; Autophagy; Autophagy-Related Protein 7; Bronchoalveolar Lavage Fluid; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Gene Knockdown Techniques; Humans; Lung; Macrolides; Male; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; RNA Interference; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transfection; Ubiquitin-Activating Enzymes | 2013 |
Pharmacological targeting of the PI3K/mTOR pathway alters the release of angioregulatory mediators both from primary human acute myeloid leukemia cells and their neighboring stromal cells.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Bone Marrow Cells; Cytogenetics; Cytokines; Female; Humans; Indazoles; Leukemia, Myeloid, Acute; Male; Middle Aged; Molecular Targeted Therapy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Sirolimus; Stromal Cells; Sulfonamides; TOR Serine-Threonine Kinases; Young Adult | 2013 |
[Effect of autophagy inhibitor 3-methyladenine on proliferation and activation of hepatic stellate cells].
Topics: Actins; Adenine; Animals; Autophagy; Cell Proliferation; Cells, Cultured; Collagen Type I; G2 Phase; Hepatic Stellate Cells; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley | 2013 |
Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients.
Topics: Adenine; Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Chromatography, Liquid; Deoxycytidine; DNA Methylation; DNA, Neoplasm; Female; Fungal Proteins; Guanine; Humans; Indicator Dilution Techniques; Limit of Detection; Lung Neoplasms; Male; Middle Aged; Reproducibility of Results; Single-Strand Specific DNA and RNA Endonucleases; Solid Phase Extraction; Tandem Mass Spectrometry; Tumor Microenvironment | 2013 |
[Molecular mechanism of ophiopogonin B induced cellular autophagy of human cervical cancer HeLa cells].
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Proliferation; Dose-Response Relationship, Drug; HeLa Cells; Humans; Membrane Proteins; Microtubule-Associated Proteins; Ophiopogon; Phosphorylation; Plants, Medicinal; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Ribosomal Protein S6 Kinases, 70-kDa; Saponins; Signal Transduction; Spirostans; TOR Serine-Threonine Kinases; Up-Regulation | 2013 |
Hydroquinone induces oxidative and mitochondrial damage to human retinal Müller cells (MIO-M1).
Topics: Adenine; Antioxidants; Apoptosis; Autophagy; Caspases; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Ependymoglial Cells; Humans; Hydroquinones; L-Lactate Dehydrogenase; Mitochondria; Reactive Oxygen Species; Retina | 2013 |
Dengue virus infection induces autophagy: an in vivo study.
Topics: Adenine; Animals; Animals, Newborn; Antimetabolites; Autophagy; Blotting, Western; Dengue; Dengue Virus; Fluorescent Antibody Technique; Immunochemistry; Immunosuppressive Agents; Mice; Mice, Inbred ICR; Microscopy, Electron, Transmission; Sirolimus; Viral Load; Virus Replication | 2013 |
Glucose-starved cells do not engage in prosurvival autophagy.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Antimetabolites; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Proteins; Beclin-1; Cell Survival; Cysteine Endopeptidases; Deoxyglucose; Fibroblasts; Glucose; HeLa Cells; Humans; Membrane Proteins; Mice; Microtubule-Associated Proteins; Sequestosome-1 Protein; Sweetening Agents; TOR Serine-Threonine Kinases; Transcription Factor TFIIH; Transcription Factors; Ubiquitin-Activating Enzymes | 2013 |
Schwann cell autophagy counteracts the onset and chronification of neuropathic pain.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; CD11b Antigen; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immunosuppressive Agents; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Pain Measurement; Schwann Cells; Sciatic Nerve; Sciatica; Sirolimus; Time Factors | 2014 |
Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.
Topics: Adenine; Animals; Autophagy; Cell Hypoxia; Cell Survival; Cells, Cultured; Deoxyglucose; Endothelial Cells; Energy Metabolism; Glycolysis; Mitochondria; Mitochondrial Proteins; Neurons; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; Reactive Oxygen Species | 2013 |
Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC-MS/MS: evidence of linkage to methylated DNA lesions.
Topics: Adenine; Adult; Biomarkers; Chromatography, Liquid; Cotinine; DNA Methylation; Guanine; Humans; Limit of Detection; Nicotine; Nitrosamines; Pyridines; Sensitivity and Specificity; Smoking; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Tumor necrosis factor-α attenuates starvation-induced apoptosis through upregulation of ferritin heavy chain in hepatocellular carcinoma cells.
Topics: Adenine; Apoferritins; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Tumor Necrosis Factor-alpha | 2013 |
Induction of autophagy contributes to the myocardial protection of valsartan against ischemia‑reperfusion injury.
Topics: Adenine; Animals; Autophagy; Cardiotonic Agents; Hemodynamics; Ischemic Preconditioning; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Signal Transduction; Tetrazoles; TOR Serine-Threonine Kinases; Valine; Valsartan | 2013 |
Autophagy as a neuroprotective mechanism against 3-nitropropionic acid-induced murine astrocyte cell death.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Astrocytes; Autophagy; bcl-2-Associated X Protein; Beclin-1; Disease Models, Animal; Huntington Disease; Mice; Nitro Compounds; Propionates; Sirolimus | 2013 |
Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Beclin-1; Cytochromes c; Diterpenes, Kaurane; Extracellular Signal-Regulated MAP Kinases; Humans; Isodon; Lung Neoplasms; Membrane Potential, Mitochondrial; Membrane Proteins; Microtubule-Associated Proteins; Mitochondria; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-met; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2013 |
Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Boronic Acids; Bortezomib; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioblastoma; Humans; Mitochondria; Proteasome Inhibitors; Pyrazines; RNA, Small Interfering; Signal Transduction; Ubiquitin-Activating Enzymes | 2014 |
Inhibition of autophagy augments chemotherapy in human salivary adenoid cystic carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Adenoid Cystic; Caspase 3; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Humans; Membrane Proteins; Mice; Mice, Nude; Microtubule-Associated Proteins; Neoplasm Transplantation; Plasmids; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Salivary Gland Neoplasms; Sequestosome-1 Protein; Transfection; Xenograft Model Antitumor Assays | 2014 |
Autophagy is activated in compression-induced cell degeneration and is mediated by reactive oxygen species in nucleus pulposus cells exposed to compression.
Topics: Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Cells, Cultured; Chloroquine; Immunohistochemistry; Intervertebral Disc; Intervertebral Disc Degeneration; Microscopy, Electron, Transmission; Rats; Reactive Oxygen Species; Stress, Mechanical | 2013 |
The dual role of autophagy in chondrocyte responses in the pathogenesis of articular cartilage degeneration in osteoarthritis.
Topics: Adenine; Aged; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cartilage, Articular; Cell Cycle; Cell Hypoxia; Cell Survival; Cells, Cultured; Chondrocytes; Female; Green Fluorescent Proteins; Humans; Male; Membrane Proteins; Microtubule-Associated Proteins; Middle Aged; Osteoarthritis; Sirolimus; Young Adult | 2013 |
Appropriate modulation of autophagy sensitizes malignant peripheral nerve sheath tumor cells to treatment with imatinib mesylate.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Benzamides; Blotting, Western; Cell Survival; Flow Cytometry; Humans; Imatinib Mesylate; Membrane Proteins; Neurilemmoma; Phagosomes; Piperazines; Pyrimidines; RNA, Small Interfering; Signal Transduction; Tumor Cells, Cultured | 2014 |
Axonal protection by Nmnat3 overexpression with involvement of autophagy in optic nerve degeneration.
Topics: Adenine; Animals; Autophagy; Axons; Cell Line; Green Fluorescent Proteins; Heat-Shock Proteins; Intraocular Pressure; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neuroprotective Agents; Nicotinamide-Nucleotide Adenylyltransferase; Optic Nerve; Protein Transport; Rats; Rats, Wistar; Retinal Ganglion Cells; Sequestosome-1 Protein; Sirolimus; Subcellular Fractions; Transfection; Tumor Necrosis Factor-alpha | 2013 |
Suppression of low-dose hyper-radiosensitivity in human lung cancer cell line A549 by radiation-induced autophagy.
Topics: Adenine; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Flow Cytometry; Green Fluorescent Proteins; Humans; Lung Neoplasms; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Phagosomes; Radiation Tolerance | 2013 |
Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Autophagy; Carbazoles; Cyclic AMP; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Isoquinolines; Resveratrol; Signal Transduction; Sirtuin 1; Stilbenes; Sulfonamides; Tumor Necrosis Factor-alpha; Vasculitis | 2013 |
Induction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancer.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Breast Neoplasms; Cadaverine; Cell Line, Tumor; Cell Survival; Cytoplasmic Vesicles; ErbB Receptors; Female; Gefitinib; Gene Knockdown Techniques; Gene Silencing; Humans; Hydroxychloroquine; Membrane Proteins; Mice; Phagosomes; Quinazolines; RNA, Small Interfering; Signal Transduction; Staining and Labeling; Tamoxifen; Treatment Outcome; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays | 2013 |
A combination of pterostilbene with autophagy inhibitors exerts efficient apoptotic characteristics in both chemosensitive and chemoresistant lung cancer cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Docetaxel; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Macrolides; Membrane Proteins; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Stilbenes; Taxoids; Time Factors; Transfection | 2014 |
Autophagy induction by low-dose cisplatin: the role of p53 in autophagy.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Cisplatin; Gene Deletion; Humans; Lung Neoplasms; Microtubule-Associated Proteins; Tumor Suppressor Protein p53 | 2014 |
Single-virus tracking approach to reveal the interaction of Dengue virus with autophagy during the early stage of infection.
Topics: Adenine; Autophagy; Cell Line, Tumor; Dengue; Dengue Virus; Host-Pathogen Interactions; Humans; Molecular Imaging; Phagosomes; Sirolimus; Virion | 2014 |
Comparison of the biological effects of MMS and Me-lex, a minor groove methylating agent: clarifying the role of N3-methyladenine.
Topics: Adenine; DNA-Directed DNA Polymerase; Humans; Methyl Methanesulfonate; Mutagens; Netropsin; Saccharomyces cerevisiae Proteins | 2014 |
Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition.
Topics: Adenine; Amino Acid Substitution; Amyloid beta-Protein Precursor; Autophagy; Blotting, Western; Cathepsin B; Cell Line, Tumor; Cell Survival; Cysteine Proteinase Inhibitors; Humans; Immunohistochemistry; Leupeptins; Mutant Proteins; Mutation; Proteasome Endopeptidase Complex; Proteolysis | 2014 |
Participation of autophagy in acute lung injury induced by seawater.
Topics: Acute Lung Injury; Adenine; Animals; Autophagy; Disease Models, Animal; Interleukin-8; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Near Drowning; Rats; Rats, Sprague-Dawley; Respiratory Aspiration; RNA, Messenger; Seawater; Tumor Necrosis Factor-alpha | 2013 |
Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro.
Topics: Adenine; Autophagy; Carcinoma; Cell Line, Tumor; Cell Survival; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Radiation Tolerance | 2014 |
Autophagy enhances the replication of classical swine fever virus in vitro.
Topics: Adenine; Animals; Autophagy; Biomarkers; Cell Line; Cell Survival; Classical Swine Fever; Classical Swine Fever Virus; Intracellular Membranes; Membrane Proteins; Microtubule-Associated Proteins; Phagosomes; RNA, Small Interfering; RNA, Viral; Sirolimus; Swine; Viral Proteins; Virus Replication | 2014 |
Autophagy contributes to IL-17-induced plasma cell differentiation in experimental autoimmune myocarditis.
Topics: Adenine; ADP-ribosyl Cyclase 1; Animals; Apoptosis Regulatory Proteins; Autoimmune Diseases; Autophagy; B-Lymphocytes; Beclin-1; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Models, Animal; Myocarditis; Myosin Heavy Chains; Plasma Cells; Positive Regulatory Domain I-Binding Factor 1; Syndecan-1; Transcription Factors | 2014 |
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK.
Topics: Adenine; Arachidonic Acid; Autophagy; Autophagy-Related Protein 7; Buthionine Sulfoximine; Carbon Tetrachloride; Cytochrome P-450 CYP2E1; Hep G2 Cells; Humans; MAP Kinase Signaling System; Mitochondria; Oxidative Stress; Sirolimus; Ubiquitin-Activating Enzymes | 2013 |
The substrate binding interface of alkylpurine DNA glycosylase AlkD.
Topics: Adenine; Catalytic Domain; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; Guanine; Models, Molecular; Mutation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity | 2014 |
AZD8055 induces cell death associated with autophagy and activation of AMPK in hepatocellular carcinoma.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Beclin-1; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Humans; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Membrane Proteins; Microtubule-Associated Proteins; Morpholines; Multiprotein Complexes; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; TOR Serine-Threonine Kinases | 2014 |
Therapeutic potential of sepantronium bromide YM155 in gemcitabine-resistant human urothelial carcinoma cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Deoxycytidine; DNA Fragmentation; Drug Resistance, Neoplasm; Everolimus; Gemcitabine; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Ki-67 Antigen; Microtubule-Associated Proteins; Naphthoquinones; Proto-Oncogene Proteins c-bcl-2; Securin; Sirolimus; Survivin; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms; Urothelium | 2014 |
The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Chloroquine; Drug Delivery Systems; Female; Humans; Immunoblotting; Lactic Acid; Mice, SCID; Nanomedicine; Nanoparticles; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Xenograft Model Antitumor Assays | 2014 |
Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cysts; Endometriosis; Endometrium; Female; Gene Expression Regulation; Humans; Menstrual Cycle; Primary Cell Culture; Sirolimus; Stromal Cells; TOR Serine-Threonine Kinases | 2014 |
Autophagy blockade sensitizes the anticancer activity of CA-4 via JNK-Bcl-2 pathway.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Biphenyl Compounds; Cell Line, Tumor; Humans; Macrolides; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Nude; Microtubule-Associated Proteins; Nitrophenols; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Stilbenes; Sulfonamides; Xenograft Model Antitumor Assays | 2014 |
Axin expression delays herpes simplex virus-induced autophagy and enhances viral replication in L929 cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Axin Protein; Beclin-1; Cell Line; Gene Expression; Gene Knockdown Techniques; Humans; Membrane Proteins; Simplexvirus; Sirolimus; Virus Replication | 2014 |
Protective effect of autophagy inhibition on ischemia-reperfusion-induced injury of N2a cells.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Survival; Mechanistic Target of Rapamycin Complex 1; Mice; Mitochondria; Multiprotein Complexes; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Reperfusion Injury; Sirolimus; TOR Serine-Threonine Kinases | 2013 |
Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Humans; Melanoma; Melanoma, Cutaneous Malignant; Membrane Proteins; Methoxsalen; Plant Extracts; Reactive Oxygen Species; Ruta; Signal Transduction; Skin Neoplasms | 2014 |
Celecoxib-induced cytotoxic effect is potentiated by inhibition of autophagy in human urothelial carcinoma cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 7; Carcinoma, Transitional Cell; Celecoxib; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; Macrolides; MAP Kinase Kinase 4; Phosphoproteins; Pyrazoles; RNA, Small Interfering; Signal Transduction; Sirolimus; Sulfonamides; Ubiquitin-Activating Enzymes; Urinary Bladder Neoplasms | 2013 |
Dendropanoxide induces autophagy through ERK1/2 activation in MG-63 human osteosarcoma cells and autophagy inhibition enhances dendropanoxide-induced apoptosis.
Topics: Adenine; Apoptosis; Autophagy; Bone Neoplasms; Cell Survival; Enzyme Activation; Humans; MAP Kinase Signaling System; Neoplasms; Osteosarcoma; Triterpenes; Tumor Cells, Cultured | 2013 |
Complete activation of autophagic process attenuates liver injury and improves survival in septic mice.
Topics: Adenine; Amebicides; Animals; Anticonvulsants; Autophagy; Carbamazepine; Chloroquine; Liver; Lysosomes; Mice; Phagosomes; Sepsis | 2014 |
Induction of autophagy restores the loss of sevoflurane cardiac preconditioning seen with prolonged ischemic insult.
Topics: Adenine; Anesthetics, Inhalation; Animals; Autophagy; Cardiotonic Agents; Chloramphenicol; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Guinea Pigs; Heart; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Methyl Ethers; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Infarction; Myocardium; Proto-Oncogene Proteins c-akt; Sevoflurane | 2014 |
The combination of RAD001 and MK-2206 exerts synergistic cytotoxic effects against PTEN mutant gastric cancer cells: involvement of MAPK-dependent autophagic, but not apoptotic cell death pathway.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Butadienes; Cell Line, Tumor; Chloroquine; Cyclin D1; Drug Synergism; Everolimus; Flavonoids; Gastric Mucosa; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 3-Ring; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nitriles; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress.
Topics: Adenine; Adult; Animals; Apoptosis; Autophagy; Blotting, Western; Case-Control Studies; Cells, Cultured; Diabetic Nephropathies; Endoplasmic Reticulum Stress; Flow Cytometry; Fluorescent Antibody Technique; Glomerulonephritis; Humans; Kidney; Male; Mice; Microscopy, Fluorescence; Middle Aged; Podocytes; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Transcription Factor CHOP | 2014 |
HSF-1 is involved in attenuating the release of inflammatory cytokines induced by LPS through regulating autophagy.
Topics: Adenine; Animals; Autophagy; Cytokines; DNA-Binding Proteins; Heat Shock Transcription Factors; Immunohistochemistry; Lipopolysaccharides; Mice; Mice, Knockout; Sirolimus; Transcription Factors | 2014 |
Heavy metal scavenger metallothionein attenuates ER stress-induced myocardial contractile anomalies: role of autophagy.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Echocardiography; Endoplasmic Reticulum Stress; Heart; Male; Metallothionein; Mice; Mice, Transgenic; Myocardial Contraction; Myocardium; Myocytes, Cardiac; Tunicamycin | 2014 |
Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model.
Topics: Adenine; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Autophagy; Benzofurans; Brain Ischemia; Cell Survival; Mice; Neuroblastoma; Sirolimus; Stroke; Tumor Cells, Cultured | 2014 |
Suppression of autophagic activation in the mouse uterus by estrogen and progesterone.
Topics: Adenine; Animals; Autophagy; Down-Regulation; Estrogens; Female; Glycogen; Mice; Mice, Inbred ICR; Ovariectomy; Pregnancy; Progesterone; Uterus | 2014 |
Apelin inhibits the proliferation and migration of rat PASMCs via the activation of PI3K/Akt/mTOR signal and the inhibition of autophagy under hypoxia.
Topics: Adenine; Adipokines; Animals; Apelin; Autophagy; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Intercellular Signaling Peptides and Proteins; Mice; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Pulmonary Artery; Rats, Wistar; Receptors, G-Protein-Coupled; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Transfection | 2014 |
SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Line; Cells, Cultured; Embryonic Stem Cells; Humans; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mice, Knockout; Microscopy, Confocal; Mitochondria; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; RNA Interference; Signal Transduction; Sirtuin 1; TOR Serine-Threonine Kinases | 2014 |
Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Arthritis, Rheumatoid; Autophagy; Autophagy-Related Proteins; Caspase 3; Cell Death; Cells, Cultured; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Fibroblasts; Immunoblotting; Immunohistochemistry; Lysosomes; Macrolides; Membrane Proteins; Microscopy, Fluorescence; Osteoarthritis; Polyubiquitin; Sequestosome-1 Protein; Synovial Membrane; Transcription Factors | 2014 |
Novel quantitative autophagy analysis by organelle flow cytometry after cell sonication.
Topics: Adenine; Autophagy; Cell Fractionation; Cell Line, Tumor; Chloroquine; Flow Cytometry; Green Fluorescent Proteins; Humans; Macrolides; Microtubule-Associated Proteins; Recombinant Fusion Proteins; Sonication; Staining and Labeling; Vacuoles | 2014 |
High autophagy in the naked mole rat may play a significant role in maintaining good health.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Hepatic Stellate Cells; Immunosuppressive Agents; Longevity; Mice; Microtubule-Associated Proteins; Mole Rats; Sirolimus | 2014 |
The c10orf10 gene product is a new link between oxidative stress and autophagy.
Topics: Adenine; Animals; Autophagy; Biomarkers; Blotting, Western; Carcinoma, Hepatocellular; Chlorocebus aethiops; Fluorescent Antibody Technique; Gene Expression Profiling; Humans; Hypoxia; Intracellular Signaling Peptides and Proteins; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Proteins; Proteolysis; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Superoxide Dismutase; Vero Cells | 2014 |
Rapamycin promoted thrombosis and platelet adhesion to endothelial cells by inducing membrane remodeling.
Topics: Adenine; Animals; Autophagy; Blood Platelets; Cell Adhesion; Cell Membrane; Cytochalasin B; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Male; Rats; Rats, Sprague-Dawley; Sirolimus; Thrombosis | 2014 |
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Brain; Brain Ischemia; Disease Models, Animal; Hypoglycemic Agents; Male; Metformin; Neuroprotective Agents; Rats; Rats, Sprague-Dawley | 2014 |
Beclin-1-mediated autophagy protects spinal cord neurons against mechanical injury-induced apoptosis.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Cells, Cultured; Female; Male; Neurons; Rats; Rats, Wistar; Sirolimus; Spinal Cord; Spinal Cord Injuries; TOR Serine-Threonine Kinases | 2014 |
Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells.
Topics: Adenine; Antineoplastic Agents; Apigenin; Apoptosis; Autophagy; Cell Cycle; Cell Line, Tumor; Colorectal Neoplasms; Cyclin B1; Humans; Signal Transduction | 2014 |
The role of autophagy induced by pemetrexed in lung adenocarcinoma cells.
Topics: Adenine; Adenocarcinoma; Adenocarcinoma of Lung; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Glutamates; Guanine; Humans; Lung Neoplasms; Pemetrexed; Poly(ADP-ribose) Polymerases; Thymidylate Synthase | 2014 |
Autophagy inhibition sensitizes bladder cancer cells to the photodynamic effects of the novel photosensitizer chlorophyllin e4.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Survival; Chlorophyllides; Humans; Lysosomes; Microtubule-Associated Proteins; Photochemotherapy; Photosensitizing Agents; Urinary Bladder Neoplasms | 2014 |
Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine‑induced death of leukaemia cells.
Topics: Adenine; Antimalarials; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Blotting, Western; Caspase 3; Cell Proliferation; Chloroquine; Cytarabine; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunophenotyping; Leukemia; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2014 |
Quantum chemical and spectroscopic investigations of 3-methyladenine.
Topics: Adenine; Models, Chemical; Spectrophotometry | 2014 |
Autophagic inhibitor attenuates rapamycin-induced inhibition of proliferation in cultured A549 lung cancer cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Death; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Membrane Proteins; Microtubule-Associated Proteins; Sirolimus | 2014 |
Effects of suppressed autophagy on mitochondrial dynamics and cell cycle of N2a cells.
Topics: Adenine; Apoptosis; Autophagy; CDC2 Protein Kinase; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin B; Cyclin-Dependent Kinases; Gene Expression Regulation; Humans; Membrane Proteins; Microtubule-Associated Proteins; Mitochondrial Dynamics; Mitochondrial Proteins; Neuroblastoma; Signal Transduction | 2014 |
Hepatic lipase release is inhibited by a purinergic induction of autophagy.
Topics: Adenine; Adenosine Diphosphate; Autophagy; Endocytosis; Hep G2 Cells; Hepatocytes; Humans; Leupeptins; Lipase; Microtubule-Associated Proteins; Protein Isoforms; Receptors, Purinergic P2; RNA Interference; RNA, Small Interfering; Time Factors | 2014 |
Airborne fine particulate matter induces multiple cell death pathways in human lung epithelial cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cell Line, Tumor; Cell Survival; Epithelial Cells; Humans; Lung; Oxidative Stress; Particulate Matter; Reactive Oxygen Species; Signal Transduction; Sirolimus | 2014 |
IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases.
Topics: Adenine; Autophagy; Cell Line; Cell Proliferation; Cell Survival; Chloroquine; Collagen Type I; Enzyme Activation; Fibroblasts; Humans; Idiopathic Pulmonary Fibrosis; Phagosomes; Protein Multimerization; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2014 |
Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Female; Humans; Male; Mice; Pancreatic Neoplasms; Pentacyclic Triterpenes; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays | 2014 |
The root hair assay facilitates the use of genetic and pharmacological tools in order to dissect multiple signalling pathways that lead to programmed cell death.
Topics: Adenine; Androstadienes; Apoptosis; Arabidopsis; Arabidopsis Proteins; Autophagy; Biological Assay; Fumonisins; Gibberellins; Hot Temperature; Hydrogen Peroxide; Indans; Mitochondrial Swelling; Models, Biological; Mutation; Mycotoxins; Organophosphonates; Phenylalanine Ammonia-Lyase; Plant Roots; Salicylic Acid; Signal Transduction; Sodium Chloride; Stress, Physiological; Wortmannin | 2014 |
Cyclovirobuxine D induces autophagy-associated cell death via the Akt/mTOR pathway in MCF-7 human breast cancer cells.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Humans; MCF-7 Cells; Microtubule-Associated Proteins; Molecular Targeted Therapy; Phosphorylation; Phytotherapy; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Hyperphosphatemia induces protective autophagy in endothelial cells through the inhibition of Akt/mTOR signaling.
Topics: Adenine; Animals; Autophagy; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Foscarnet; Humans; Hyperphosphatemia; Male; Microtubule-Associated Proteins; Phosphates; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Renal Insufficiency, Chronic; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Transfection | 2015 |
A combination of four active compounds alleviates cerebral ischemia-reperfusion injury in correlation with inhibition of autophagy and modulation of AMPK/mTOR and JNK pathways.
Topics: Adenine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autophagy; Brain; Brain Infarction; Cyclooctanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Ginsenosides; Infarction, Middle Cerebral Artery; Lignans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Polycyclic Compounds; Renal Circulation; Reperfusion Injury; Saponins; Time Factors; TOR Serine-Threonine Kinases | 2014 |
Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Proteins; Biomarkers, Tumor; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Female; Heme Oxygenase-1; Humans; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Ovarian Neoplasms; RNA-Binding Proteins; Signal Transduction; Small Ubiquitin-Related Modifier Proteins; Ubiquitin-Conjugating Enzymes | 2014 |
Hypoxia Induces autophagic cell death through hypoxia-inducible factor 1α in microglia.
Topics: Adenine; Autophagy; Cell Hypoxia; Cell Line; Enzyme-Linked Immunosorbent Assay; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microglia; Microscopy, Electron, Transmission | 2014 |
Autophagy inhibitor 3-methyladenine potentiates apoptosis induced by dietary tocotrienols in breast cancer cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Dietary Supplements; Epithelial Cells; Female; Humans; Mammary Glands, Human; Tocotrienols | 2015 |
Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Carrier Proteins; Hydroxamic Acids; Inflammasomes; Macrophages; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; NLR Family, Pyrin Domain-Containing 3 Protein; Pneumonia; Reactive Oxygen Species; Respiration, Artificial; Signal Transduction; Stress, Mechanical; Ventilator-Induced Lung Injury | 2014 |
Autophagy inhibitors promoted aristolochic acid I induced renal tubular epithelial cell apoptosis via mitochondrial pathway but alleviated nonapoptotic cell death in mouse acute aritolochic acid nephropathy model.
Topics: Adenine; Animals; Apoptosis; Aristolochia; Aristolochic Acids; Autophagy; Chloroquine; Drugs, Chinese Herbal; Endoplasmic Reticulum Stress; Epithelial Cells; Kidney Diseases; Kidney Tubules; Mice; Mice, Inbred BALB C; Mitochondria | 2014 |
Bortezomib induces protective autophagy through AMP-activated protein kinase activation in cultured pancreatic and colorectal cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Cell Survival; Cells, Cultured; Chloroquine; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Neoplasm Proteins; Pancreatic Neoplasms; Proteasome Inhibitors; Protein Kinase Inhibitors; Pyrazines; RNA Interference; RNA, Small Interfering | 2014 |
Microglial activation with reduction in autophagy limits white matter lesions and improves cognitive defects during cerebral hypoperfusion.
Topics: Adenine; Animals; Autophagy; Carotid Stenosis; Cognition Disorders; Cytokines; Disease Models, Animal; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Microglia; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Time Factors; White Matter | 2014 |
Autophagy inhibition switches low-dose camptothecin-induced premature senescence to apoptosis in human colorectal cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Autophagy; Camptothecin; Cell Line, Tumor; Cellular Senescence; Chloroquine; Class III Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Lysosomes; Neoplasm Proteins; Osmolar Concentration; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy.
Topics: Adenine; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Benzamides; Benzodioxoles; Calcium Signaling; Cardiotonic Agents; Cell Survival; Chickens; Diabetes Mellitus, Type 1; Forkhead Box Protein O3; Forkhead Transcription Factors; Glucose; Heart; Membrane Potential, Mitochondrial; Mice, Transgenic; Mitochondria; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Streptozocin | 2015 |
Role of autophagy and mTOR signaling in neural differentiation of bone marrow mesenchymal stem cells.
Topics: Adenine; Animals; Autophagy; Bone Marrow Cells; Cell Differentiation; Down-Regulation; Mercaptoethanol; Mesenchymal Stem Cells; Neurogenesis; Rats; Rats, Wistar; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2014 |
Effect of autophagy inhibition on cell viability and cell cycle progression in MDA‑MB‑231 human breast cancer cells.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 7; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Female; Humans; RNA Interference; RNA, Small Interfering; Ubiquitin-Activating Enzymes | 2014 |
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; CD4-Positive T-Lymphocytes; Cell Proliferation; Cellular Microenvironment; Cyclooxygenase 2; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Knockdown Techniques; Inflammation; Inflammation Mediators; Lymphocyte Activation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred C57BL; Reactive Oxygen Species; RNA, Small Interfering | 2014 |
The anti-tumor efficiency of pterostilbene is promoted with a combined treatment of Fas signaling or autophagy inhibitors in triple negative breast cancer cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Autophagy; beta Catenin; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; fas Receptor; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Signal Transduction; Stilbenes; Triple Negative Breast Neoplasms; Vimentin | 2014 |
Taurine rescues cisplatin-induced muscle atrophy in vitro: a morphological study.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Cisplatin; Mice; Muscle Fibers, Skeletal; Muscular Atrophy; Necrosis; Taurine; Time Factors; Tubulin | 2014 |
Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Cell Survival; Glucose; Macrolides; Mice; Microtubule-Associated Proteins; NF-kappa B; Podocytes; Signal Transduction; Time Factors | 2014 |
Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Boronic Acids; Bortezomib; Heat-Shock Proteins; Lysosomes; Mice; Mice, Transgenic; Myocytes, Cardiac; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Proteolysis; Pyrazines; Rats; Sequestosome-1 Protein; Ubiquitin | 2014 |
Connecting endoplasmic reticulum stress to autophagy through IRE1/JNK/beclin-1 in breast cancer cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Breast Neoplasms; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Endoribonucleases; Female; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Tunicamycin | 2014 |
Suppressing autophagy protects photoreceptor cells from light-induced injury.
Topics: Adenine; Animals; Autophagy; Cell Line; Chromones; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Light; MAP Kinase Signaling System; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Photoreceptor Cells, Vertebrate | 2014 |
Alkylpurine glycosylase D employs DNA sculpting as a strategy to extrude and excise damaged bases.
Topics: Adenine; Bacillus cereus; Bacterial Proteins; DNA; DNA Glycosylases; DNA Repair; Models, Molecular; Nucleic Acid Conformation; Thermodynamics | 2014 |
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy.
Topics: 1-Methyl-4-phenylpyridinium; Adenine; Autophagy; Case-Control Studies; Caspases; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lysosomes; Macrolides; Mutation; Parkinson Disease; Phenotype; Protein Serine-Threonine Kinases; Risk Factors; TOR Serine-Threonine Kinases; Transfection | 2014 |
3-Methyladenine can depress drug efflux transporters via blocking the PI3K-AKT-mTOR pathway thus sensitizing MDR cancer to chemotherapy.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Mice, Inbred BALB C; Multidrug Resistance-Associated Proteins; Paclitaxel; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2014 |
Reactive oxygen species-dependent JNK downregulated olaquindox-induced autophagy in HepG2 cells.
Topics: Adenine; Anthracenes; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cadaverine; Down-Regulation; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Quinoxalines; Reactive Oxygen Species | 2015 |
Apogossypolone inhibits the proliferation of LNCaP cells in vitro and in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; Beclin-1; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Gossypol; Humans; In Situ Nick-End Labeling; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Proto-Oncogene Proteins c-bcl-2; Xenograft Model Antitumor Assays | 2014 |
Bioenergetic adaptation in response to autophagy regulators during rotenone exposure.
Topics: Adenine; Animals; Autophagy; Cell Survival; Cells, Cultured; Cerebral Cortex; DNA Damage; DNA, Mitochondrial; Dose-Response Relationship, Drug; Embryo, Mammalian; Energy Metabolism; Enzyme Inhibitors; Insecticides; Lactosylceramides; Neurons; Oligomycins; Oxygen Consumption; Rats; Rotenone; Sirolimus | 2014 |
Ebb-and-flow of macroautophagy and chaperone-mediated autophagy in Raji cells induced by starvation and arsenic trioxide.
Topics: Adenine; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Autophagy; Burkitt Lymphoma; Cell Line, Tumor; Humans; Molecular Chaperones; Oxides; Starvation | 2014 |
Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cerebral Infarction; Ischemic Postconditioning; Ischemic Preconditioning; Male; Models, Animal; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2014 |
Glucosamine protects nucleus pulposus cells and induces autophagy via the mTOR-dependent pathway.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cadaverine; Cell Survival; Cellular Senescence; Dose-Response Relationship, Drug; Glucosamine; Hydrogen Peroxide; Interleukin-1beta; Intervertebral Disc; Intervertebral Disc Degeneration; Microscopy, Fluorescence; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases | 2014 |
A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF).
Topics: Acetylcysteine; Adenine; Androstenedione; Autophagy; Bone Neoplasms; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Macrophage Migration-Inhibitory Factors; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Secosteroids; Translocation, Genetic | 2014 |
Arsenic trioxide induces autophagy and antitumor effects in Burkitt's lymphoma Raji cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Autophagy; Beclin-1; Burkitt Lymphoma; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Down-Regulation; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Humans; Membrane Proteins; Oxides; Up-Regulation | 2014 |
Autophagy promotes paclitaxel resistance of cervical cancer cells: involvement of Warburg effect activated hypoxia-induced factor 1-α-mediated signaling.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Autophagy; Autophagy-Related Protein 7; Deoxyglucose; Down-Regulation; Drug Resistance, Neoplasm; Female; Glycolysis; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Paclitaxel; RNA Interference; Sesquiterpenes; Signal Transduction; Ubiquitin-Activating Enzymes; Up-Regulation; Uterine Cervical Neoplasms | 2014 |
Inhibition of akt phosphorylation diminishes mitochondrial biogenesis regulators, tricarboxylic acid cycle activity and exacerbates recognition memory deficit in rat model of Alzheimer's disease.
Topics: Adenine; Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Animals; Citric Acid Cycle; Cyclic AMP Response Element-Binding Protein; Discrimination, Psychological; Disease Models, Animal; Down-Regulation; Exploratory Behavior; Hippocampus; Injections, Intraventricular; Male; Memory Disorders; Mitochondria; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Complex; Rats, Wistar; Recognition, Psychology | 2014 |
Efavirenz induces neuronal autophagy and mitochondrial alterations.
Topics: Adenine; Adenosine Triphosphate; Alkynes; Animals; Autophagy; Benzoxazines; Cell Line; Cyclopropanes; Humans; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Neurons; Rats; Rats, Sprague-Dawley | 2014 |
Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway.
Topics: Acute Disease; Adenine; Adult; Animals; Autophagy; Autophagy-Related Protein 7; Cells, Cultured; Chemokines; Cytokines; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Female; Galactosamine; Hepatitis B; Hepatocytes; Humans; Inflammation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Liver Failure; Macrophages; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Middle Aged; Phosphorylation; PPAR alpha; Protective Agents; Pyrimidines; RNA Interference; RNA, Small Interfering; Toll-Like Receptor 4; Transcription Factor RelA | 2014 |
Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells.
Topics: Abietanes; Adenine; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; Gene Silencing; Hep G2 Cells; Humans; Liver Neoplasms; Macrolides; Phosphatidylinositol 3-Kinases; Phosphorylation; Plant Extracts; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; TOR Serine-Threonine Kinases | 2015 |
Inhibition of autophagy augments apoptosis in human oral squamous cell carcinoma under nutrient depletion.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Green Fluorescent Proteins; Humans; KB Cells; Membrane Proteins; Microtubule-Associated Proteins; Mouth Neoplasms; Recombinant Proteins; Transfection | 2015 |
Justicidin A-induced autophagy flux enhances apoptosis of human colorectal cancer cells via class III PI3K and Atg5 pathway.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Colorectal Neoplasms; Dioxolanes; HT29 Cells; Humans; Lignans; Mice; Mice, SCID; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; RNA, Small Interfering; Signal Transduction | 2015 |
Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Glioma; Humans; Microtubule-Associated Proteins; Mitochondria; Pyridines; Radiation Tolerance; Radiation, Ionizing; RNA Interference; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins | 2015 |
Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Exenatide; Hepatocytes; Humans; Macrolides; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Non-alcoholic Fatty Liver Disease; Peptides; Reperfusion Injury; Venoms | 2014 |
Apoptosis, necrosis, and autophagy in mouse intestinal damage after 15-Gy whole body irradiation.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autophagy; Body Weight; Caspase 3; Caspase Inhibitors; Enterocytes; Enzyme Inhibitors; Feces; HMGB1 Protein; Imidazoles; Indoles; Intestinal Mucosa; Intestines; Male; Mice, Inbred C57BL; Necrosis; Radiation Dosage; Reactive Oxygen Species; Whole-Body Irradiation | 2014 |
Protective roles of aldo-keto reductase 1B10 and autophagy against toxicity induced by p-quinone metabolites of tert-butylhydroquinone in lung cancer A549 cells.
Topics: Adenine; Aldehyde Reductase; Aldo-Keto Reductases; Antioxidants; Autophagy; Benzoquinones; Caspase 3; Cell Line, Tumor; Endoplasmic Reticulum; Glutathione; Humans; Hydroquinones; Lung Neoplasms; Microtubule-Associated Proteins | 2015 |
Effects of 3-methyladenine on isolated left atria subjected to simulated ischaemia-reperfusion.
Topics: Adenine; Animals; Autophagy; Female; Heart Atria; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Treatment Outcome | 2015 |
Autophagy modulates endoplasmic reticulum stress-induced cell death in podocytes: a protective role.
Topics: Adenine; Animals; Anti-Bacterial Agents; Apoptosis; Autophagy; Cell Line; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Mice; Models, Animal; Phagosomes; Podocytes; Sirolimus; Thapsigargin; Tunicamycin | 2015 |
DRAM1 protects neuroblastoma cells from oxygen-glucose deprivation/reperfusion-induced injury via autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain Ischemia; Cell Line, Tumor; Cell Survival; Glucose; Lysosomes; Membrane Proteins; Mice; Microtubule-Associated Proteins; Neuroblastoma; Oxygen; Reperfusion Injury; Up-Regulation | 2014 |
p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum.
Topics: Adenine; Autophagy; Cellular Senescence; Culture Media, Serum-Free; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; Humans; Phosphorylation; Stress, Mechanical; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2015 |
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.
Topics: Adenine; Amino Acid Sequence; Antimalarials; Apicoplasts; Autophagy; Autophagy-Related Protein 8 Family; Chloroquine; Doxycycline; Erythrocytes; Gene Expression Regulation; Genome, Protozoan; Humans; Leucine; Life Cycle Stages; Microfilament Proteins; Molecular Sequence Data; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2014 |
Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein.
Topics: Adenine; alpha-Synuclein; Animals; Autophagy; Cell Death; Gene Expression; Leupeptins; Mutation; PC12 Cells; Proteasome Inhibitors; Rats; TOR Serine-Threonine Kinases | 2015 |
How to reduce the accumulation of autophagic vacuoles in NPC1-deficient neurons: a comparison of two pharmacological strategies.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adenine; Animals; Autophagy; beta-Cyclodextrins; Cells, Cultured; Cerebral Cortex; Cholesterol; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Lysosomal-Associated Membrane Protein 2; Lysosomes; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microtubule-Associated Proteins; Neurons; Niemann-Pick C1 Protein; Proteins; Time Factors; Vacuoles | 2015 |
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD.
Topics: Adenine; Animals; Apolipoprotein E4; Autophagy; Cell Survival; Gene Expression Regulation; Glutathione; Humans; Hydrogen Peroxide; Lipofuscin; Macular Degeneration; Membrane Potentials; Mice; Mice, Inbred C57BL; Oxidative Stress; Reactive Oxygen Species; Retina; Retinal Pigment Epithelium | 2014 |
Autophagy functions on EMT in gastrulation of avian embryo.
Topics: Adenine; Animals; Autophagy; Cadherins; Cell Adhesion Molecules; Chick Embryo; Epithelial-Mesenchymal Transition; Gastrula; Gastrulation; Gene Expression Regulation, Developmental; Germ Layers; HCT116 Cells; Humans; Microtubule-Associated Proteins; Models, Biological; Sirolimus | 2014 |
Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.
Topics: Adenine; Animals; Autophagy; Cell Death; Cell Line, Tumor; Chloroquine; Embryo, Mammalian; Endoplasmic Reticulum Stress; Fibroblasts; HEK293 Cells; Humans; Macrolides; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes; Nelfinavir; Signal Transduction; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2015 |
Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal "metastability" in primary hepatocytes determining in vitro cell survival.
Topics: Adenine; Aldehydes; Animals; Apoptosis; Autophagy; Culture Media, Conditioned; Endocytosis; Epidermal Growth Factor; Female; Ferritins; Glutathione; Glutathione Disulfide; Hepatocytes; Intracellular Membranes; Iron Chelating Agents; Leupeptins; Liver; Lysosomes; Molecular Imaging; Permeability; Primary Cell Culture; Protease Inhibitors; Protein Aggregates; Rats; Rats, Inbred F344 | 2015 |
ASPP2 enhances oxaliplatin (L-OHP)-induced colorectal cancer cell apoptosis in a p53-independent manner by inhibiting cell autophagy.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cell Line, Tumor; Colorectal Neoplasms; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Middle Aged; Mutation; Organoplatinum Compounds; Oxaliplatin; RNA Interference; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2015 |
Raloxifene induces autophagy-dependent cell death in breast cancer cells via the activation of AMP-activated protein kinase.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Breast Neoplasms; Caspases; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Membrane Proteins; Microtubule-Associated Proteins; Raloxifene Hydrochloride; Signal Transduction | 2015 |
Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons.
Topics: 3,4-Methylenedioxyamphetamine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Survival; Cells, Cultured; Intracellular Signaling Peptides and Proteins; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley; Signal Transduction | 2014 |
Citreoviridin induces ROS-dependent autophagic cell death in human liver HepG2 cells.
Topics: Adenine; Aurovertins; Autophagy; Autophagy-Related Protein 5; Cell Survival; Hep G2 Cells; Humans; Liver; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Phagosomes; Reactive Oxygen Species; RNA Interference | 2015 |
Ubenimex inhibits cell proliferation, migration and invasion in renal cell carcinoma: the effect is autophagy-associated.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Aminopeptidases; Antibiotics, Antineoplastic; Autophagy; Carcinoma, Renal Cell; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Leucine; Middle Aged; Neoplasm Invasiveness; Sirolimus; Wound Healing; Young Adult | 2015 |
Inhibition of microtubule-associated protein 1 light chain 3B via small-interfering RNA or 3-methyladenine impairs hypoxia-induced HO8910PM and HO8910 epithelial ovarian cancer cell migration and invasion and is associated with RhoA and alterations of the
Topics: Actin Cytoskeleton; Adenine; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Neoplasm Invasiveness; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering | 2015 |
Sinomenine hydrochloride protects against polymicrobial sepsis via autophagy.
Topics: Adenine; Animals; Autophagy; Cecum; Cell Line; Cytokines; Disease Models, Animal; Kidney; Lipopolysaccharides; Liver; Lung; Macrophages; Male; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Morphinans; Sepsis; Survival Rate | 2015 |
Autophagy regulates colistin-induced apoptosis in PC-12 cells.
Topics: Adenine; Animals; Anti-Bacterial Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Colistin; Microtubule-Associated Proteins; PC12 Cells; Rats; Vacuoles | 2015 |
NS5ATP9 Promotes Beclin 1-Dependent Starvation-Induced Autophagy of Hepatoblastoma Cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carrier Proteins; Cell Proliferation; Chloroquine; DNA-Binding Proteins; Hep G2 Cells; Hepatoblastoma; Humans; Liver Neoplasms; Membrane Proteins; Stress, Physiological | 2015 |
Modulating polyplex-mediated gene transfection by small-molecule regulators of autophagy.
Topics: Active Transport, Cell Nucleus; Adenine; Animals; Autophagy; Biopharmaceutics; DNA; Gene Expression; Gene Transfer Techniques; Mice; Microscopy, Electron, Transmission; NIH 3T3 Cells; Phagosomes; Polymers; Reactive Oxygen Species; Sirolimus; Transfection | 2015 |
Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model.
Topics: Adenine; Animals; Autophagy; Brain; Cell Hypoxia; Cerebral Arteries; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Microglia; Sirolimus; Stroke; Tumor Necrosis Factor-alpha | 2015 |
Lycium barbarum polysaccharide improves bipolar pulse current-induced microglia cell injury through modulating autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Caspase 7; Cell Line; Drugs, Chinese Herbal; Electric Stimulation; Extracellular Signal-Regulated MAP Kinases; Inflammation; Lycium; Mice; Microglia; Microscopy, Fluorescence; Microtubule-Associated Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Sirolimus; Time-Lapse Imaging | 2015 |
α-Lipoic acid protects against hypoxia/reoxygenation-induced injury in human umbilical vein endothelial cells through suppression of apoptosis and autophagy.
Topics: Adenine; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase 3; Cell Hypoxia; Dose-Response Relationship, Drug; Gene Expression; Glucose; Human Umbilical Vein Endothelial Cells; Humans; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Membrane Proteins; Microtubule-Associated Proteins; Models, Biological; Oxygen; Phagosomes; Reperfusion Injury; Thioctic Acid | 2015 |
Inhibition of autophagy by 3-methyladenine potentiates sulforaphane-induced cell death of BE(2)-C human neuroblastoma cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Isothiocyanates; Membrane Potential, Mitochondrial; Neuroblastoma; Reactive Oxygen Species; Sulfoxides | 2015 |
Paradoxical effects of the autophagy inhibitor 3-methyladenine on docetaxel-induced toxicity in PC-3 and LNCaP prostate cancer cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Docetaxel; Humans; Male; Prostatic Neoplasms; Taxoids | 2015 |
Impact of autophagy inhibition at different stages on cytotoxic effect of autophagy inducer in glioblastoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Arsenicals; Autophagy; Beclin-1; Blotting, Western; Brain Neoplasms; Caspase 3; Cell Line, Tumor; Chloroquine; Drug Synergism; Flow Cytometry; Glioblastoma; Humans; Membrane Proteins; Microscopy, Electron, Transmission; Oxides; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; RNA Interference; RNA, Small Interfering | 2015 |
Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Cell Shape; Cell Survival; Fluorescent Antibody Technique; Malondialdehyde; Microtubule-Associated Proteins; PC12 Cells; Rats; Reactive Oxygen Species; Sirolimus; Superoxide Dismutase; Triazines | 2016 |
Novel steps in the autophagic-lysosomal pathway.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Hepatocytes; Lysosomes; Male; Microtubule-Associated Proteins; Protein Processing, Post-Translational; Proteolysis; Rats, Wistar | 2015 |
Canonical autophagy does not contribute to cellular radioresistance.
Topics: Adenine; Autophagy; Cell Line, Tumor; Chloroquine; DNA Repair; Humans; Phosphorylation; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Signal Transduction | 2015 |
Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Cell Proliferation; Collagen Type I; Fibronectins; Fibrosis; Heart Atria; Humans; Macrolides; Mice; Microtubule-Associated Proteins; Myofibroblasts; Primary Cell Culture; Rats; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta1 | 2015 |
Heat-modified citrus pectin induces apoptosis-like cell death and autophagy in HepG2 and A549 cancer cells.
Topics: Adenine; Apoptosis; Autophagy; Carrier Proteins; Caspase Inhibitors; Caspases; Cell Line, Tumor; Hep G2 Cells; Hot Temperature; Humans; Macrolides; Microfilament Proteins; Pectins; Ubiquitination | 2015 |
NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice.
Topics: Adenine; Animals; Animals, Newborn; Autophagy; Caspase 3; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABAergic Neurons; Gene Expression Regulation; Glutamate Decarboxylase; Immunosuppressive Agents; In Vitro Techniques; L-Lactate Dehydrogenase; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mitochondria; Models, Biological; Receptors, N-Methyl-D-Aspartate; Time Factors | 2015 |
Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Cells, Cultured; Diabetes Mellitus, Type 2; Diet, High-Fat; Flavonols; Gene Expression Regulation; Insulin Resistance; Macrolides; Male; Muscle, Skeletal; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Chloroquine enhances gefitinib cytotoxicity in gefitinib-resistant nonsmall cell lung cancer cells.
Topics: Adenine; Antineoplastic Agents; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chloroquine; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Quinazolines | 2015 |
Inhibition of Hedgehog signaling pathway impedes cancer cell proliferation by promotion of autophagy.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Hedgehog Proteins; Humans; Kruppel-Like Transcription Factors; Neoplasms; Nuclear Proteins; Pyridines; Pyrimidines; Signal Transduction; Transcriptome; Zinc Finger Protein Gli2 | 2015 |
Simultaneous Detection of 3-Nitrotyrosine and 3-Nitro-4-hydroxyphenylacetic Acid in Human Urine by Online SPE LC-MS/MS and Their Association with Oxidative and Methylated DNA Lesions.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenine; Adult; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deoxyguanosine; Dimethylnitrosamine; DNA Methylation; Guanine; Humans; Limit of Detection; Middle Aged; Nitrophenols; Oxidation-Reduction; Phenylacetates; Solid Phase Extraction; Tandem Mass Spectrometry; Tyrosine; Young Adult | 2015 |
Inhibition of autophagy using 3-methyladenine increases cisplatin-induced apoptosis by increasing endoplasmic reticulum stress in U251 human glioma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Caspases, Initiator; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Cisplatin; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Glioma; Heat-Shock Proteins; Humans; Microscopy, Confocal; Protein Disulfide-Isomerases | 2015 |
Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy.
Topics: Adenine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Autophagy; CHO Cells; CREB-Binding Protein; Cricetulus; Disease Models, Animal; Gene Expression Regulation; Green Fluorescent Proteins; Hippocampus; Humans; Lamotrigine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Presenilin-1; Triazines | 2015 |
Autophagy potentially protects against 2,3,7,8-tetrachlorodibenzo-p-Dioxin induced apoptosis in SH-SY5Y cells.
Topics: Acetylcysteine; Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Oxidative Stress; Phenotype; Polychlorinated Dibenzodioxins; Protective Agents; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species | 2016 |
Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Autophagy; beta-Cyclodextrins; Carrier Proteins; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; Membrane Microdomains; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 8; Myocytes, Cardiac; Phosphoproteins; Phosphorylcholine; Primary Cell Culture; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sphingosine; TOR Serine-Threonine Kinases | 2015 |
Combining radiation with autophagy inhibition enhances suppression of tumor growth and angiogenesis in esophageal cancer.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagus; Humans; Membrane Proteins; Mice; Mice, Nude; Microtubule-Associated Proteins; Neovascularization, Pathologic; Radiation Tolerance; Radiation, Ionizing; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2015 |
Autophagy activation attenuates renal ischemia-reperfusion injury in rats.
Topics: Acute Kidney Injury; Adenine; Animals; Apoptosis; Autophagy; Blood Urea Nitrogen; Caspase 3; Creatinine; Disease Models, Animal; In Situ Nick-End Labeling; Male; Rats; Rats, Wistar; Reperfusion Injury; Sirolimus | 2015 |
Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells.
Topics: Adenine; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Beclin-1; Cytochrome Reductases; Hep G2 Cells; Hepatocytes; Humans; Membrane Proteins; Microtubule-Associated Proteins; Oxidoreductases Acting on Sulfur Group Donors; Signal Transduction; Time Factors; Transfection; Ubiquitin-Activating Enzymes | 2015 |
17AAG improves histological and functional outcomes in a rat CCI model through autophagy activation and apoptosis attenuation.
Topics: Adenine; Animals; Apoptosis; Autophagy; Benzoquinones; Brain Edema; Brain Injuries; Cell Survival; Cerebral Cortex; Female; Lactams, Macrocyclic; Motor Skills; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Sirolimus | 2015 |
Autophagy protects renal tubular cells against ischemia / reperfusion injury in a time-dependent manner.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Gene Expression Regulation; Kidney Tubules; Male; Mice; Reperfusion Injury; Sirolimus; Time Factors | 2015 |
Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Antineoplastic Agents; Antirheumatic Agents; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein 8 Family; Cell Differentiation; Chloroquine; Granulocytes; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Microfilament Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Tretinoin; Ubiquitin-Activating Enzymes | 2015 |
Participation of autophagy in the cytotoxicity against breast cancer cells by cisplatin.
Topics: Adenine; Antineoplastic Agents; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cisplatin; Cyclophosphamide; Docetaxel; Epirubicin; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Methotrexate; Taxoids | 2015 |
Cocaine-mediated microglial activation involves the ER stress-autophagy axis.
Topics: Adenine; Androstadienes; Animals; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Biomarkers; Cell Line; Cell Survival; Cocaine; Endoplasmic Reticulum Stress; Mice, Inbred C57BL; Microglia; Models, Biological; Phagosomes; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proteins; Rats; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Time Factors; Wortmannin | 2015 |
Melatonin Ameliorates Arsenite-Induced Neurotoxicity: Involvement of Autophagy and Mitochondria.
Topics: Adenine; alpha-Synuclein; Animals; Antioxidants; Arsenites; Autophagy; Biomarkers; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Electron Transport Complex IV; Female; Lysosomes; Melatonin; Mitochondria; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pregnancy; Rats; Rats, Sprague-Dawley; Sodium Compounds; Transcription Factors | 2015 |
[Protective effects of 3-methyladenine on acute lung injury caused by multiple trauma in rats].
Topics: Acute Lung Injury; Adenine; Animals; Apoptosis Regulatory Proteins; Beclin-1; Interleukin-6; Lung; Male; Multiple Trauma; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2015 |
Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Caspases; Cell Death; Cell Line; Cell Proliferation; Cell Survival; Chondrocytes; Collagen Type II; Cytochromes c; Gene Deletion; Growth Plate; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Macrolides; Metatarsal Bones; Mice; Mice, Knockout; Microtubule-Associated Proteins; Proteins; Rats; Ubiquitin-Activating Enzymes | 2015 |
[Activated autophagy in spinal cord contributes to maintaining diabetic neuropathic pain in rats model].
Topics: Adenine; Animals; Autophagy; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Male; Neuralgia; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Cord; Streptozocin | 2015 |
Extrusion of mitochondrial contents from lipopolysaccharide-stimulated cells: Involvement of autophagy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Nucleus; DNA, Mitochondrial; Fibroblasts; Gene Expression Regulation; Hepatocytes; Lipopolysaccharides; Lysosomes; Male; Mice; Microtubule-Associated Proteins; Mitochondria; Mitochondrial Proteins; Models, Biological; Neutrophil Activation; Phagosomes; Protein Transport; Rats, Sprague-Dawley; Subcellular Fractions; Vacuoles | 2015 |
Autophagy protects meniscal cells from glucocorticoids-induced apoptosis via inositol trisphosphate receptor signaling.
Topics: Adenine; Apoptosis; Autophagy; Cells, Cultured; Dexamethasone; Endopeptidases; Extracellular Matrix; Female; Humans; Inositol 1,4,5-Trisphosphate Receptors; Menisci, Tibial; Osteosarcoma; Phosphorylation; RNA, Messenger; Signal Transduction; Sirolimus | 2015 |
Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Cardiomegaly; Carrier Proteins; Disease Models, Animal; Intracellular Signaling Peptides and Proteins; Isoflavones; Isoproterenol; Male; Microtubule-Associated Proteins; Myocardium; Myocytes, Cardiac; Phosphoproteins; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; TOR Serine-Threonine Kinases; Ventricular Remodeling | 2015 |
Daucosterol inhibits cancer cell proliferation by inducing autophagy through reactive oxygen species-dependent manner.
Topics: Acetylcysteine; Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glutathione; Humans; Mice; Neoplasms; Reactive Oxygen Species; Sitosterols; Tumor Stem Cell Assay | 2015 |
Autophagy of cytoplasmic bulk cargo does not require LC3.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Cycloheximide; Cytoplasm; Hepatocytes; Humans; Microtubule-Associated Proteins; Rats; Thapsigargin | 2016 |
Autophagy inhibition enhances isorhamnetin‑induced mitochondria‑dependent apoptosis in non‑small cell lung cancer cells.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Carcinoma, Non-Small-Cell Lung; Caspases; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Dose-Response Relationship, Drug; Drug Synergism; Epithelial Cells; Gene Expression; Humans; Hydroxychloroquine; Lung Neoplasms; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Microtubule-Associated Proteins; Mitochondria; Quercetin; Xenograft Model Antitumor Assays | 2015 |
High-resolution Digital Mapping of N-Methylpurines in Human Cells Reveals Modulation of Their Induction and Repair by Nearest-neighbor Nucleotides.
Topics: Adenine; Cell Line; DNA Repair; Fibroblasts; Guanine; Humans; Sulfuric Acid Esters | 2015 |
Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway.
Topics: A549 Cells; Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dioxolanes; Female; Humans; Lung Neoplasms; Mice; Mice, Nude; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Cell Cycle Proteins; Cell Movement; Gene Expression Regulation, Neoplastic; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Leupeptins; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Metastasis; Neoplasms, Experimental; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Repressor Proteins; Sequestosome-1 Protein; Tissue Array Analysis; Ubiquitin | 2015 |
The Role of Autophagy in Kidney Inflammatory Injury via the NF-κB Route Induced by LPS.
Topics: Acute Kidney Injury; Adenine; Animals; Autophagy; Disease Models, Animal; Immunohistochemistry; Inflammation; Kidney; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; NF-kappa B; Phosphorylation; Ubiquitin | 2015 |
Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Butadienes; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Macrolides; Microtubule-Associated Proteins; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Nitriles; Organoplatinum Compounds; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Proliferation; Chalcones; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Macrolides; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2015 |
Decreased autophagy: a major factor for cardiomyocyte death induced by β1-adrenoceptor autoantibodies.
Topics: Adenine; Adrenergic beta-1 Receptor Antagonists; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autoantibodies; Autophagy; Beclin-1; Cardiomyopathies; Cell Line; Gene Expression Regulation; Humans; Immunization, Passive; Male; Myocytes, Cardiac; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Dysfunction, Left; Ventricular Pressure | 2015 |
Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Lung Neoplasms; Macrolides; Mesothelioma; Mesothelioma, Malignant; Mice, Nude; Microtubule-Associated Proteins; Pemetrexed; Pepstatins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Simvastatin; Time Factors; TOR Serine-Threonine Kinases; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Low concentrations of chloroquine and 3-methyladenine suppress the viability of retinoblastoma cells synergistically with vincristine independent of autophagy inhibition.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Antirheumatic Agents; Apoptosis; Autophagy; Blotting, Western; Cell Cycle Checkpoints; Cell Survival; Chloroquine; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Microtubule-Associated Proteins; Retinal Neoplasms; Retinoblastoma; RNA-Binding Proteins; Sincalide; Tumor Cells, Cultured; Vincristine | 2015 |
Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Autophagy; Carrier Proteins; HEK293 Cells; Humans; Immunoblotting; Microfilament Proteins; Microscopy, Confocal; Oligopeptides; Proteasome Endopeptidase Complex; Protein Binding; Protein Serine-Threonine Kinases; Proteolysis; RNA Interference; Sequestosome-1 Protein | 2015 |
N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cadaverine; Cell Line; Cytoprotection; Dose-Response Relationship, Drug; Haloperidol; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Microtubule-Associated Proteins; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Rats; RNA Interference; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transfection | 2015 |
Inhibition of autophagy by 3-MA enhances IL-24-induced apoptosis in human oral squamous cell carcinoma cells.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression; Genetic Therapy; Humans; Interleukins; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Neoplasms, Squamous Cell; Transfection; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Melamine induces autophagy in mesangial cells via enhancing ROS level.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Free Radical Scavengers; Hydrogen Peroxide; Mesangial Cells; Oxidants; Oxidative Stress; Rats; Reactive Oxygen Species; Triazines | 2015 |
Dissection of autophagy in tobacco BY-2 cells under sucrose starvation conditions using the vacuolar H(+)-ATPase inhibitor concanamycin A and the autophagy-related protein Atg8.
Topics: Adenine; Autophagy; Cells, Cultured; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Fluorescence; Green Fluorescent Proteins; Hydrogen-Ion Concentration; Intracellular Membranes; Leucine; Lysosomes; Macrolides; Nicotiana; Phagosomes; Plant Proteins; Proteolysis; Recombinant Fusion Proteins; Sucrose; Vacuolar Proton-Translocating ATPases; Vacuoles | 2015 |
Strain-Dependent Effect of Macroautophagy on Abnormally Folded Prion Protein Degradation in Infected Neuronal Cells.
Topics: Adenine; Animals; Autophagy; Cell Line; Gerstmann-Straussler-Scheinker Disease; Humans; MAP Kinase Signaling System; Mice; Protein Folding; Proteolysis; PrPSc Proteins; Sirolimus | 2015 |
Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Autophagy; Blotting, Western; Caspases; Cattle; Cells, Cultured; Child; Culture Media; Female; Fetal Blood; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Male; Middle Aged; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Sirtuin 1 | 2015 |
Radiocontrast-induced nephropathy is attenuated by autophagy through regulation of apoptosis and inflammation.
Topics: Acute Kidney Injury; Adenine; Animals; Apoptosis; Autophagy; Cell Culture Techniques; Cell Line; Cell Survival; Chemokines; Contrast Media; Immunohistochemistry; In Situ Nick-End Labeling; Iohexol; Kidney Function Tests; Kidney Tubules; Macrophages; Male; Mice, Inbred C57BL; Oxidative Stress; Rats | 2016 |
Nanoparticles modulate autophagic effect in a dispersity-dependent manner.
Topics: Adenine; Autophagy; Carboxylic Acids; Cell Line, Tumor; Citrates; Gold; HeLa Cells; Humans; Lysosomal Membrane Proteins; Metal Nanoparticles; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Silver; Sodium Citrate; Succimer; Surface Properties; Suspensions; Unithiol; Up-Regulation | 2015 |
Autophagy in human skin squamous cell carcinoma: Inhibition by 3-MA enhances the effect of 5-FU-induced chemotherapy sensitivity.
Topics: Adenine; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Synergism; Fluorouracil; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Invasiveness; Proto-Oncogene Proteins c-bcl-2; Skin Neoplasms; Survivin | 2015 |
Sulforaphane Protects the Liver against CdSe Quantum Dot-Induced Cytotoxicity.
Topics: Adenine; Androstadienes; Animals; Autophagy; Cadmium Compounds; Cell Death; Cell Line; Gene Knockdown Techniques; Glutathione; Humans; Intracellular Signaling Peptides and Proteins; Intracellular Space; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver; Metallothionein; Mice, Inbred ICR; NF-E2-Related Factor 2; Protective Agents; Quantum Dots; RNA, Messenger; Selenium Compounds; Sulfoxides; Transcription, Genetic; Wortmannin | 2015 |
Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
Topics: Adenine; Animals; Cyclic AMP; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Phosphodiesterase Inhibitors; Rats; Rats, Wistar | 2015 |
Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 5; Butadienes; Cell Line, Tumor; Cell Survival; Chloroquine; Europium; Extracellular Signal-Regulated MAP Kinases; Green Fluorescent Proteins; HeLa Cells; Humans; Huntingtin Protein; Hydroxides; Lysosomes; Macrolides; Mice; Microscopy, Fluorescence; Microtubule-Associated Proteins; Nanotubes; Nerve Tissue Proteins; Neurodegenerative Diseases; Nitriles; Phagosomes; Phosphorylation; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Trehalose; Wortmannin | 2015 |
The Effect of Autophagy on Inflammation Cytokines in Renal Ischemia/Reperfusion Injury.
Topics: Acute Kidney Injury; Adenine; Animals; Anti-Inflammatory Agents; Autophagy; Beclin-1; Enzyme Activation; HMGB1 Protein; Inflammation; Interleukin-10; Interleukin-6; Kidney; Lysosomal-Associated Membrane Protein 2; Male; Microtubule-Associated Proteins; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Tumor Necrosis Factor-alpha | 2016 |
Inhibition of Autophagy Increases Proliferation Inhibition and Apoptosis Induced by the PI3K/mTOR Inhibitor NVP-BEZ235 in Breast Cancer Cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Protein 7; Breast Neoplasms; Cell Proliferation; Cell Survival; Chloroquine; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; MCF-7 Cells; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolines; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Transfection; Ubiquitin-Activating Enzymes | 2015 |
Inhibition of autophagy induced by quercetin at a late stage enhances cytotoxic effects on glioma cells.
Topics: Adenine; Animals; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chloroquine; Glioma; Humans; Male; Neoplasm Staging; Quercetin; Rats; Rats, Sprague-Dawley | 2016 |
Blocking autophagy enhances meloxicam lethality to hepatocellular carcinoma by promotion of endoplasmic reticulum stress.
Topics: Adenine; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2 Inhibitors; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Hep G2 Cells; Humans; Liver Neoplasms; Meloxicam; Microtubule-Associated Proteins; RNA Interference; RNA, Small Interfering; Thiazines; Thiazoles | 2015 |
Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells.
Topics: Adenine; Antineoplastic Agents, Hormonal; Autophagy; Caspase 3; Cell Cycle; Choline Kinase; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Tamoxifen; TOR Serine-Threonine Kinases | 2015 |
Puquitinib mesylate (XC-302) induces autophagy via inhibiting the PI3K/AKT/mTOR signaling pathway in nasopharyngeal cancer cells.
Topics: Adenine; Aminoquinolines; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Humans; Membrane Proteins; Microscopy, Confocal; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Molecular Structure; Nasopharyngeal Neoplasms; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity.
Topics: Adenine; Animals; Autophagy; Cytochrome P-450 CYP2E1; Ethanol; Liver; Liver Diseases, Alcoholic; Male; Mice; Sirolimus | 2015 |
Defective nuclear entry of hydrolases prevents neutrophil extracellular trap formation in patients with chronic granulomatous disease.
Topics: Adenine; Androstadienes; Benzylamines; Candida albicans; Cell Nucleus; Extracellular Traps; Granulomatous Disease, Chronic; Histones; Humans; Hydrolases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Tetradecanoylphorbol Acetate; Wortmannin | 2015 |
G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Female; Granulocyte Colony-Stimulating Factor; Humans; Locomotion; Mice; Neurons; NF-kappa B; Random Allocation; Recombinant Proteins; Recovery of Function; Spinal Cord Injuries | 2015 |
Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice.
Topics: Adenine; Animals; Apoptosis; Autophagy; bcl-2-Associated X Protein; Body Water; Brain Chemistry; Brain Injuries; Cerebral Cortex; Cytochromes c; Male; Melatonin; Mice; Mitochondria; Neuroprotective Agents; Signal Transduction | 2015 |
FoxO3α-mediated autophagy contributes to apoptosis in cardiac microvascular endothelial cells under hypoxia.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Silencing; Male; Microvessels; Myocardial Infarction; Myocardium; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sirolimus | 2016 |
Autophagy Inhibitor 3-MA Weakens Neuroprotective Effects of Posttraumatic Brain Injury Moderate Hypothermia.
Topics: Adenine; Animals; Autophagy; Brain Injuries; Hypothermia, Induced; Male; Neuroprotection; Rats; Rats, Sprague-Dawley; Recovery of Function; Treatment Outcome | 2016 |
Blue light emitting diode induces apoptosis in lymphoid cells by stimulating autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; B-Lymphocytes; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; DNA Fragmentation; Female; Humans; Light; Lymphoma, B-Cell; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Mitochondria; Neoplasm Transplantation; Phagosomes; Phototherapy; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Superoxides | 2016 |
Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Disease Models, Animal; Macrophages; Mice; Osteoblasts; Osteoclasts; Osteolysis | 2015 |
Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity.
Topics: Adenine; Animals; Autophagy; Benzylamines; Brain Stem; Cells, Cultured; Citalopram; Dose-Response Relationship, Drug; Down-Regulation; Fluorine Radioisotopes; Functional Neuroimaging; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Degeneration; Neurites; Neuroprotective Agents; Phagosomes; Positron-Emission Tomography; Rats; Serotonergic Neurons; Serotonin Plasma Membrane Transport Proteins | 2016 |
NPAS4 Facilitates the Autophagic Clearance of Endogenous Tau in Rat Cortical Neurons.
Topics: Adenine; Animals; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cerebral Cortex; Chloroquine; Cyclin-Dependent Kinase 5; Glycogen Synthase Kinase 3; Leupeptins; Neurons; Proteolysis; Rats; Rats, Sprague-Dawley; tau Proteins | 2016 |
Induction of autophagy by the MG‑132 proteasome inhibitor is associated with endoplasmic reticulum stress in MCF‑7 cells.
Topics: Adenine; Apoptosis; Autophagy; Cinnamates; Drug Synergism; Endoplasmic Reticulum Stress; Humans; Leupeptins; MCF-7 Cells; Proteasome Inhibitors; Thiourea | 2016 |
[Sodium nitrite reduces lipid accumulation in steatotic cells by enhancing autophagy].
Topics: Adenine; Autophagy; Blotting, Western; Cells, Cultured; Chloroquine; Cytoplasm; Fatty Liver; Hepatocytes; Humans; Lipid Metabolism; Microscopy, Fluorescence; Microtubule-Associated Proteins; Oleic Acid; Sodium Nitrite; Triglycerides | 2015 |
Autophagy postpones apoptotic cell death in PRRSV infection through Bad-Beclin1 interaction.
Topics: Adenine; Animals; Apoptosis; Autophagy; bcl-Associated Death Protein; Beclin-1; Cell Line; Chlorocebus aethiops; Porcine respiratory and reproductive syndrome virus; Virus Replication | 2016 |
Ramalin-Mediated Apoptosis Is Enhanced by Autophagy Inhibition in Human Breast Cancer Cells.
Topics: Adenine; Antineoplastic Agents; Antioxidants; Apoptosis; Apoptosis Inducing Factor; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Biological Products; Breast Neoplasms; Caspases; Cell Cycle; Cell Proliferation; Cytochromes c; Female; Glutamates; Humans; Lichens; Microtubule-Associated Proteins; Mitochondria; Proto-Oncogene Proteins c-bcl-2 | 2016 |
The Dichotomy of Endoplasmic Reticulum Stress Response in Liver Ischemia-Reperfusion Injury.
Topics: Activating Transcription Factors; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Proteins; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Liver; Liver Diseases; Male; Mice, Inbred C57BL; Microtubule-Associated Proteins; Phenylbutyrates; Proto-Oncogene Proteins c-akt; Reperfusion Injury; Signal Transduction; Time Factors; Ubiquitin-Conjugating Enzymes; Warm Ischemia | 2016 |
[Keratin 18 phosphorylation increases autophagy of colorectal cancer HCT116 cells and enhanced its sensitivity to oxaliplatin].
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Colorectal Neoplasms; Flow Cytometry; HCT116 Cells; Humans; Keratin-18; Microscopy, Fluorescence; Mutation; Organoplatinum Compounds; Oxaliplatin; Phosphorylation; Serine; Sirolimus; Transfection | 2016 |
Autophagy Promotes Microglia Activation Through Beclin-1-Atg5 Pathway in Intracerebral Hemorrhage.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cells, Cultured; Cerebral Cortex; Cerebral Hemorrhage; Erythrocytes; Macrolides; Mice; Microglia; Signal Transduction | 2017 |
Targeting non-canonical autophagy overcomes erlotinib resistance in tongue cancer.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Autophagy-Related Protein 5; Beclin-1; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Erlotinib Hydrochloride; Humans; Hydroxychloroquine; RNA, Small Interfering; Sirolimus; Tongue Neoplasms; Up-Regulation | 2016 |
Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Epithelial-Mesenchymal Transition; Humans; Limonins; MAP Kinase Signaling System; Neoplasm Metastasis; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species | 2016 |
Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling.
Topics: Adenine; Alcohol Dehydrogenase; Animals; Autophagy; Calcium; Endoplasmic Reticulum Stress; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; Mice, Transgenic; Myocardial Contraction; Myocardium; Oxidative Stress; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Recombinant Fusion Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transgenes; Tunicamycin; Ultrasonography; Ventricular Dysfunction, Left | 2016 |
[Autophagy inhibitor 3-methyladenine enhances the sensitivity of nasopharyngeal carcinoma cells to chemotherapy and radiotherapy].
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Humans; Membrane Potential, Mitochondrial; Membrane Proteins; Microtubule-Associated Proteins; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Radiation-Sensitizing Agents; Radiation, Ionizing; Tunicamycin | 2016 |
Endogenous grouper and barramundi Mx proteins facilitated the clearance of betanodavirus RNA-dependent RNA polymerase.
Topics: Adenine; Amino Acid Sequence; Ammonium Chloride; Animals; Autophagy; Brain; Cell Line; Fish Diseases; Mitochondria; Myxovirus Resistance Proteins; Nodaviridae; Perches; Poly I-C; RNA Interference; RNA Virus Infections; RNA-Dependent RNA Polymerase; RNA, Small Interfering; Virus Replication | 2016 |
The Protective Role of Autophagy in Matrix Metalloproteinase-Mediated Cell Transmigration and Cell Death in High-Glucose-Treated Endothelial Cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Line; Cell Movement; Diabetes Mellitus; Dipeptides; Endothelium, Vascular; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Poly(ADP-ribose) Polymerases | 2016 |
Colchicine induces autophagy and senescence in lung cancer cells at clinically admissible concentration: potential use of colchicine in combination with autophagy inhibitor in cancer therapy.
Topics: A549 Cells; Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Cycle; Cell Line; Cellular Senescence; Colchicine; Dose-Response Relationship, Drug; Fibroblasts; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Microtubules; Reactive Oxygen Species; Spindle Apparatus; Tubulin Modulators | 2016 |
Graphene Oxide Attenuates the Cytotoxicity and Mutagenicity of PCB 52 via Activation of Genuine Autophagy.
Topics: Adenine; Androstadienes; Animals; Autophagy; CD59 Antigens; Cell Line; Cricetinae; Graphite; Humans; Hybrid Cells; Mutagens; Oxides; Polychlorinated Biphenyls; Sirolimus; Trehalose; Wortmannin | 2016 |
Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
Topics: Adenine; Androstadienes; Animals; Antigens, Differentiation; Apoptosis; Autophagy; Brain Ischemia; Cells, Cultured; Cerebral Cortex; Glucose; Neurons; Oxygen; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Wortmannin | 2016 |
Autophagy protects podocytes from sublytic complement induced injury.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Complement Membrane Attack Complex; Kidney Glomerulus; Mice; Podocytes | 2016 |
Autophagy protects osteoblasts from advanced glycation end products-induced apoptosis through intracellular reactive oxygen species.
Topics: Adenine; Animals; Antioxidants; Apoptosis; Autophagy; Cell Line; Cell Survival; Glycation End Products, Advanced; Intracellular Space; Membrane Potential, Mitochondrial; Mice; Mitochondria; Osteoblasts; Oxidative Stress; Reactive Oxygen Species | 2016 |
Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; bcl-X Protein; Beclin-1; Cell Line, Tumor; Humans; Indoles; Jurkat Cells; Leukemia, T-Cell; Poly(ADP-ribose) Polymerases; Triterpenes | 2016 |
Chemical inhibition of autophagy: Examining its potential to increase the specific productivity of recombinant CHO cell lines.
Topics: Adenine; Androstadienes; Animals; Autophagy; Bioreactors; Cell Culture Techniques; CHO Cells; Chromones; Cricetinae; Cricetulus; Morpholines; Recombinant Proteins; Wortmannin | 2016 |
Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention.
Topics: Adenine; Animals; Apoptosis; Arteries; Autophagy; Endothelial Cells; Graft Occlusion, Vascular; Neointima; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Veins | 2016 |
Effects of Cellular Pathway Disturbances on Misfolded Superoxide Dismutase-1 in Fibroblasts Derived from ALS Patients.
Topics: Adenine; Age of Onset; Aging; Amyotrophic Lateral Sclerosis; Autophagy; Bortezomib; C9orf72 Protein; Case-Control Studies; Cells, Cultured; DNA Repeat Expansion; Electron Transport Complex I; Endoplasmic Reticulum Stress; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Genotype; Humans; Mutation; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Aggregation, Pathological; Protein Folding; Proteins; Proteolysis; Rotenone; Solubility; Superoxide Dismutase; Superoxide Dismutase-1 | 2016 |
Autophagy promotes DNA-protein crosslink clearance.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Camptothecin; Cell Line, Tumor; Cell Survival; Chloroquine; DNA Damage; Formaldehyde; Gene Silencing; Humans; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus; Ubiquitin-Activating Enzymes; Ultraviolet Rays | 2016 |
Moderate activation of autophagy regulates the intracellular calcium ion concentration and mitochondrial membrane potential in beta-amyloid-treated PC12 cells.
Topics: Adenine; Amyloid beta-Peptides; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Calcium; Cell Survival; Intracellular Space; Membrane Potential, Mitochondrial; Mitochondria; PC12 Cells; Peptide Fragments; Phagosomes; Rats; Sirolimus | 2016 |
Induction of Autophagy interferes the tachyzoite to bradyzoite transformation of Toxoplasma gondii.
Topics: Adenine; Autophagy; Cell Line; Down-Regulation; Fibroblasts; Foreskin; Humans; Male; Organisms, Genetically Modified; Protein Kinase Inhibitors; Sirolimus; Toxoplasma | 2016 |
Autophagy regulates intracerebral hemorrhage induced neural damage via apoptosis and NF-κB pathway.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Cerebral Hemorrhage; Male; Mice; Mice, Inbred ICR; Neurons; NF-kappa B; Signal Transduction | 2016 |
Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Beclin-1; Body Weight; Cognition Disorders; Diabetes Mellitus, Experimental; Disease Models, Animal; Eating; Exploratory Behavior; Hippocampus; Hypoglycemic Agents; Long-Term Potentiation; Male; Maze Learning; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Perforant Pathway; RNA, Long Noncoding; Streptozocin | 2016 |
Time-Dependent Changes in Apoptosis Upon Autophagy Inhibition in Astrocytes Exposed to Oxygen and Glucose Deprivation.
Topics: Adenine; Animals; Animals, Newborn; Apoptosis; Astrocytes; Autophagy; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Glucose; Rats; Rats, Wistar; Time Factors | 2017 |
Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Cell Line, Tumor; Humans; Hydrogen Peroxide; Microtubule-Associated Proteins; Oxidative Stress; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Sirtuins; Transfection | 2016 |
ER stress and autophagy are involved in the apoptosis induced by cisplatin in human lung cancer cells.
Topics: A549 Cells; Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Proliferation; Chloroquine; Cisplatin; Endoplasmic Reticulum Stress; Humans; Inhibitory Concentration 50; Lung Neoplasms; Membrane Potential, Mitochondrial | 2016 |
Autophagy Plays a Protective Role in Tumor Necrosis Factor-α-Induced Apoptosis of Bone Marrow-Derived Mesenchymal Stem Cells.
Topics: Adenine; Adult; Apoptosis; Autophagy; Beclin-1; Bone Marrow Cells; Cell Differentiation; Cycloheximide; Female; Humans; Male; Mesenchymal Stem Cells; Multipotent Stem Cells; Phenotype; RNA, Small Interfering; Sirolimus; Tumor Necrosis Factor-alpha | 2016 |
Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Colitis; Corticotropin-Releasing Hormone; Dextran Sulfate; Disease Models, Animal; Fibroblasts; Gastrointestinal Tract; Gene Knockout Techniques; Male; Mice; Proteomics; RAW 264.7 Cells | 2016 |
Autophagy mediated TiAl₆V₄ particle-induced peri-implant osteolysis by promoting expression of TNF-α.
Topics: Adenine; Aged; Aged, 80 and over; Alloys; Animals; Autophagy; Disease Models, Animal; Female; Humans; Macrophages; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Middle Aged; Osteolysis; p38 Mitogen-Activated Protein Kinases; Prosthesis Failure; Titanium; Tumor Necrosis Factor-alpha; Up-Regulation; X-Ray Microtomography | 2016 |
Optimized method for TAG protein homology modeling: In silico and experimental structural characterization.
Topics: Acinetobacter baumannii; Adenine; Amino Acid Sequence; Bacterial Proteins; Cloning, Molecular; DNA Glycosylases; DNA, Bacterial; Enzyme Inhibitors; Escherichia coli; Gene Expression; Molecular Docking Simulation; Mutation; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Alignment; Structural Homology, Protein; Substrate Specificity; Thermodynamics; User-Computer Interface | 2016 |
Autophagy inhibition in endogenous and nutrient-deprived conditions reduces dorsal root ganglia neuron survival and neurite growth in vitro.
Topics: Adenine; Animals; Autophagy; Cell Survival; Culture Media; Ganglia, Spinal; Macrolides; Male; Nerve Regeneration; Neurites; Neurons; Phagosomes; Rats; Rats, Sprague-Dawley; Sirolimus | 2016 |
Autophagy inhibition sensitizes WYE-354-induced anti-colon cancer activity in vitro and in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Colonic Neoplasms; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Multiprotein Complexes; Purines; TOR Serine-Threonine Kinases | 2016 |
Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Ginsenosides; Humans; Jurkat Cells; Mitochondria; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species; RNA Interference | 2016 |
Procyanidins from Nelumbo nucifera Gaertn. Seedpod induce autophagy mediated by reactive oxygen species generation in human hepatoma G2 cells.
Topics: Adenine; Autophagy; Biflavonoids; Catechin; Cell Proliferation; Cell Shape; DNA Breaks, Double-Stranded; Hep G2 Cells; Humans; Intracellular Space; Membrane Potential, Mitochondrial; Nelumbo; Proanthocyanidins; Reactive Oxygen Species; S Phase; Seeds | 2016 |
The protective role of autophagy in experimental osteoarthritis, and the therapeutic effects of Torin 1 on osteoarthritis by activating autophagy.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Arthritis, Experimental; Autophagy; Beclin-1; Cartilage; Cell Line, Tumor; Chondrocytes; Cytoprotection; Humans; Male; Matrix Metalloproteinase 13; Membrane Proteins; Microtubule-Associated Proteins; Naphthyridines; Rabbits; Severity of Illness Index; Tissue Inhibitor of Metalloproteinase-1; Vascular Endothelial Growth Factor A | 2016 |
β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Proteins; beta-Arrestins; Cells, Cultured; Class III Phosphatidylinositol 3-Kinases; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glucose; Humans; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Podocytes; RNA Interference; Transforming Growth Factor beta1; Ubiquitin-Conjugating Enzymes; Up-Regulation | 2016 |
Gypenoside XVII Enhances Lysosome Biogenesis and Autophagy Flux and Accelerates Autophagic Clearance of Amyloid-β through TFEB Activation.
Topics: Adenine; Alzheimer Disease; Amines; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autophagy; Autophagy-Related Protein 5; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Brain; Disease Models, Animal; Gynostemma; Lysosomes; Maze Learning; Mice; Mice, Transgenic; Microtubule-Associated Proteins; PC12 Cells; Plant Extracts; Presenilin-1; Protein Transport; Rats | 2016 |
Chemopreventive Metabolites Are Correlated with a Change in Intestinal Microbiota Measured in A-T Mice and Decreased Carcinogenesis.
Topics: 4-Butyrolactone; Adenine; Animals; Cell Transformation, Neoplastic; Gastrointestinal Microbiome; Intestinal Neoplasms; Mice; Mice, Knockout | 2016 |
Hinokitiol protects primary neuron cells against prion peptide-induced toxicity via autophagy flux regulated by hypoxia inducing factor-1.
Topics: Adenine; Androstadienes; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Microscopy, Electron, Transmission; Monoterpenes; Neurons; Neuroprotective Agents; Peptide Fragments; Primary Cell Culture; Prion Diseases; Prions; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Signal Transduction; Tropolone; Wortmannin | 2016 |
Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Proteins; Beclin-1; Calpain; Cells, Cultured; Cytokines; Fatty Liver; Hepatocytes; Humans; Immunohistochemistry; Liver; Mice; Mice, Inbred C57BL; Mice, Obese; Microtubule-Associated Proteins; Point Mutation; Reperfusion Injury; Ubiquitin-Conjugating Enzymes; Up-Regulation | 2016 |
The synergistic effect of resveratrol in combination with cisplatin on apoptosis via modulating autophagy in A549 cells.
Topics: A549 Cells; Adenine; Adenocarcinoma, Bronchiolo-Alveolar; Apoptosis; Autophagosomes; Autophagy; Cisplatin; Drug Synergism; Humans; Lung Neoplasms; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Neoplasm Proteins; Proto-Oncogene Proteins c-akt; Resveratrol; RNA-Binding Proteins; Stilbenes | 2016 |
Radiation induces autophagic cell death via the p53/DRAM signaling pathway in breast cancer cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Female; Humans; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Membrane Proteins; Microtubule-Associated Proteins; Oligonucleotide Array Sequence Analysis; Phosphoric Monoester Hydrolases; Radiation, Ionizing; RNA Interference; RNA, Small Interfering; Tumor Suppressor Protein p53; Up-Regulation | 2016 |
Role of autophagy in the bimodal stage after spinal cord ischemia reperfusion injury in rats.
Topics: Adenine; Animals; Apoptosis; Autophagy; Central Nervous System Agents; Disease Models, Animal; Male; Motor Activity; Neuroimmunomodulation; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Spinal Cord; Spinal Cord Ischemia | 2016 |
Nicotinate-Curcumin Impedes Foam Cell Formation from THP-1 Cells through Restoring Autophagy Flux.
Topics: Adenine; Atherosclerosis; Autophagy; Cell Line; Chloroquine; Cholesterol; Curcumin; Foam Cells; Humans; Lipid Metabolism; Lipoproteins, LDL; Macrophages; Niacin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Akap1 Deficiency Promotes Mitochondrial Aberrations and Exacerbates Cardiac Injury Following Permanent Coronary Ligation via Enhanced Mitophagy and Apoptosis.
Topics: A Kinase Anchor Proteins; Adenine; Animals; Apoptosis; Blotting, Western; Disease Models, Animal; Echocardiography; In Situ Nick-End Labeling; Mice; Mice, Knockout; Microscopy, Electron; Mitochondria; Mitophagy; Myocardial Infarction; Reactive Oxygen Species; Ubiquitin-Protein Ligases | 2016 |
Intrathecal Injection of 3-Methyladenine Reduces Neuronal Damage and Promotes Functional Recovery via Autophagy Attenuation after Spinal Cord Ischemia/Reperfusion Injury in Rats.
Topics: Adenine; Animals; Autophagy; Beclin-1; Injections, Spinal; Male; Microtubule-Associated Proteins; Neurons; Neuroprotective Agents; Rats, Sprague-Dawley; Reperfusion Injury; Spinal Cord Ischemia | 2016 |
Proper autophagy is indispensable for angiogenesis during chick embryo development.
Topics: Adenine; Angiodysplasia; Animals; Autophagy; Autophagy-Related Proteins; Cell Movement; Chick Embryo; Chorioallantoic Membrane; Embryonic Development; Endothelium, Vascular; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Microtubule-Associated Proteins; Neovascularization, Physiologic; Sirolimus | 2016 |
Vitamin D3 supplementation alleviates rotavirus infection in pigs and IPEC-J2 cells via regulating the autophagy signaling pathway.
Topics: Adenine; Animals; Antigens, Viral; Autophagy; Beclin-1; Cathelicidins; Cell Line; Cell Survival; Cholecalciferol; Epithelial Cells; Gene Expression Regulation; Glycoproteins; Host-Pathogen Interactions; Ileum; Jejunum; Macrolides; Microtubule-Associated Proteins; RNA, Messenger; Rotavirus; Rotavirus Infections; Sequestosome-1 Protein; Signal Transduction; Swine; Swine Diseases; Toxins, Biological; Viral Nonstructural Proteins | 2016 |
Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.
Topics: Adenine; Animals; Apoptosis; Ascorbic Acid; Autophagy; Biphenyl Compounds; Caspase 3; Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Glioma; Lignans; Mice; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2016 |
Preconditioning of endoplasmic reticulum stress protects against acrylonitrile-induced cytotoxicity in primary rat astrocytes: The role of autophagy.
Topics: Acrylonitrile; Adenine; Animals; Animals, Newborn; Astrocytes; Autophagy; Carcinogens; Cells, Cultured; Cerebral Cortex; Deoxyglucose; Dithiothreitol; Endoplasmic Reticulum Stress; Glial Fibrillary Acidic Protein; Heat-Shock Proteins; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Oxidoreductases; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2016 |
Procyanidins, from Castanea mollissima Bl. shell, induces autophagy following apoptosis associated with PI3K/AKT/mTOR inhibition in HepG2 cells.
Topics: Adenine; Apoptosis; Autophagy; Biflavonoids; Catechin; Cell Proliferation; Green Fluorescent Proteins; Hep G2 Cells; Hippocastanaceae; Humans; Neoplasm Proteins; Oligopeptides; Phosphatidylinositol 3-Kinases; Proanthocyanidins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling.
Topics: Adenine; Animals; Autophagy; Male; Mice; Mice, Inbred C57BL; Mitochondria, Muscle; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Recovery of Function; Regeneration; Wound Healing | 2016 |
The Shu complex promotes error-free tolerance of alkylation-induced base excision repair products.
Topics: Adenine; Alkylation; Camptothecin; Cisplatin; DNA Damage; DNA Polymerase beta; DNA Repair; DNA, Fungal; Epistasis, Genetic; Etoposide; Genes, Fungal; Genetic Loci; Homologous Recombination; Humans; Hydrogen Peroxide; Hydroxyurea; Methyl Methanesulfonate; Models, Biological; Mutation; Mutation Rate; Protein Binding; Radiation, Ionizing; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays | 2016 |
Inhibition of autophagy and enhancement of endoplasmic reticulum stress increase sensitivity of osteosarcoma Saos-2 cells to cannabinoid receptor agonist WIN55,212-2.
Topics: Adenine; Apoptosis; Autophagy; Benzoxazines; Cannabinoid Receptor Agonists; Cell Line, Tumor; Cell Proliferation; Chloroquine; Endoplasmic Reticulum Stress; Humans; Mitochondria; Morpholines; Naphthalenes; Osteosarcoma; Signal Transduction; Up-Regulation | 2016 |
The autophagy pathway participates in resistance to tomato yellow leaf curl virus infection in whiteflies.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Begomovirus; DNA Primers; Female; Genomics; Gossypium; Hemiptera; Insect Vectors; Male; Plant Diseases; Sirolimus | 2016 |
Autophagic effects of Hibiscus sabdariffa leaf polyphenols and epicatechin gallate (ECG) against oxidized LDL-induced injury of human endothelial cells.
Topics: Adenine; Antioxidants; Apoptosis; Autophagy; Beclin-1; Catechin; Cell Proliferation; Cell Survival; Cells, Cultured; Hibiscus; Human Umbilical Vein Endothelial Cells; Humans; Lipoproteins, LDL; Phenanthrenes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Plant Leaves; Polyphenols; PTEN Phosphohydrolase | 2017 |
Activation of volume-sensitive Cl- channel mediates autophagy-related cell death in myocardial ischaemia/reperfusion injury.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Proliferation; Chloride Channels; Cytokines; Hydrogen-Ion Concentration; Hypoxia; Inflammation; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Microtubule-Associated Proteins; Myocardial Ischemia; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; RNA Interference | 2016 |
[Effect of autophagy inhibitor combined with EGFR inhibitor on triple-negative breast cancer MDA-MB-468 and MDA-MB-231 cells].
Topics: Adenine; Antineoplastic Agents; Autophagy; Autophagy-Related Proteins; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Gefitinib; Humans; Macrolides; MCF-7 Cells; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Triple Negative Breast Neoplasms | 2016 |
RIP3 induces ischemic neuronal DNA degradation and programmed necrosis in rat via AIF.
Topics: Adenine; Animals; Apoptosis Inducing Factor; Brain Ischemia; Cell Nucleus; Disease Models, Animal; DNA Degradation, Necrotic; Imidazoles; Indoles; Male; Neurons; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor-Interacting Protein Serine-Threonine Kinases; Reperfusion Injury | 2016 |
Neutrophil gelatinase-associated lipocalin worsens ischemia/reperfusion damage of kidney cells by autophagy.
Topics: Acute Kidney Injury; Adenine; Autophagy; Blotting, Western; Cell Line; Cell Survival; Chloroquine; Fluorescent Antibody Technique; Humans; Kidney Tubules; Lipocalin-2; Microtubule-Associated Proteins; Recombinant Proteins; Reperfusion Injury | 2016 |
The anti-cancer activity of the mTORC1/2 dual inhibitor XL388 in preclinical osteosarcoma models.
Topics: Adenine; Adolescent; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Bone Neoplasms; Caspases; Cell Line, Tumor; Cell Survival; Gene Silencing; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, SCID; Neoplasm Transplantation; Osteosarcoma; Phosphorylation; Sulfones; Treatment Outcome; Tumor Cells, Cultured; Young Adult | 2016 |
Nano-TiO
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antioxidants; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Cytoprotection; Enzyme Activation; Mice; Nanoparticles; Oxidative Stress; Podocytes; Signal Transduction; Sirolimus; Titanium; TOR Serine-Threonine Kinases | 2016 |
Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Diabetes Mellitus; Exenatide; Insulin-Secreting Cells; Lysosomes; Macrolides; Male; Oxidative Stress; Peptides; Phagosomes; Protective Agents; Rats, Sprague-Dawley; Tacrolimus; Venoms | 2016 |
Upregulation of SQSTM1/p62 contributes to nickel-induced malignant transformation of human bronchial epithelial cells.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Bronchi; Cell Line, Tumor; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Macrolides; Male; Mice, Inbred C57BL; Nickel; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases; Transcription, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation | 2016 |
Survival or death: a dual role for autophagy in stress-induced pericyte loss in diabetic retinopathy.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Autophagy; Beclin-1; Cell Survival; Diabetic Retinopathy; Endoplasmic Reticulum Stress; Glycation End Products, Advanced; Humans; Immunohistochemistry; Lipoproteins, LDL; MAP Kinase Signaling System; Mice; Oxidation-Reduction; Oxidative Stress; Pericytes; Retina; Transcription Factor CHOP | 2016 |
Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance.
Topics: Adenine; Autophagy; Cells, Cultured; Culture Media; Glucose; Humans; Insulin Resistance; Membrane Proteins; Osmolar Concentration; Phosphorylation; Podocytes; Receptor, Insulin; Sirolimus | 2016 |
Autophagy Inhibition Favors Survival of Rubrospinal Neurons After Spinal Cord Hemisection.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Rats, Wistar; Recovery of Function; Spinal Cord; Spinal Cord Injuries | 2017 |
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Bacterial Proteins; Beclin-1; Cell Membrane; Cell Proliferation; Class III Phosphatidylinositol 3-Kinases; Dogs; Ehrlichia chaffeensis; Ehrlichiosis; Enzyme Activation; Glutamic Acid; Glutamine; Guanosine Triphosphate; HEK293 Cells; Host-Pathogen Interactions; Humans; Huntingtin Protein; Inclusion Bodies; Mutant Proteins; Protein Binding; rab5 GTP-Binding Proteins; Signal Transduction; Sirolimus; Ubiquitination | 2016 |
PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.
Topics: Adenine; Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Autophagy; Calcium; Cell Line, Tumor; Disease Progression; Fibroblasts; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Mitochondria; Mitochondrial Membranes; Oncogene Proteins, Fusion; Oxides; Promyelocytic Leukemia Protein; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2016 |
Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Benzofurans; Chromones; Colorectal Neoplasms; Drugs, Chinese Herbal; Female; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Morpholines; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Salvia miltiorrhiza; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Associations between autophagy, the ubiquitin-proteasome system and endoplasmic reticulum stress in hypoxia-deoxygenation or ischemia-reperfusion.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Line; Cell Survival; Doxorubicin; Endoplasmic Reticulum Stress; Histone Deacetylase 6; Histone Deacetylases; Leupeptins; Lung; Male; NF-kappa B; Oxygen; Proteasome Endopeptidase Complex; Rats; Reperfusion Injury; Sirolimus; Ubiquitin | 2016 |
The role of kaempferol-induced autophagy on differentiation and mineralization of osteoblastic MC3T3-E1 cells.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cell Line; Flavonoids; Kaempferols; Mice; Osteogenesis | 2016 |
Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells.
Topics: Adenine; Annexin A5; Apoptosis; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; Caspases; Cell Cycle; Cell Survival; Chromones; DNA Fragmentation; Dynamins; Flow Cytometry; Fluorescein-5-isothiocyanate; Humans; Jurkat Cells; Membrane Potential, Mitochondrial; Mitochondria; Morpholines; Trimethyl Ammonium Compounds | 2016 |
Role of autophagy in cellular response to infection with Orf virus Jilin isolate.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Chloroquine; Ecthyma, Contagious; Host-Pathogen Interactions; Microscopy, Electron, Transmission; Orf virus; Sheep; Sirolimus; Virus Replication | 2016 |
Gemcitabine-Induced Autophagy Protects Human Lung Cancer Cells from Apoptotic Death.
Topics: A549 Cells; Adenine; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Beclin-1; Caspase 3; Cell Survival; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Membrane Proteins; Microtubule-Associated Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Tumor Suppressor Proteins | 2016 |
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Topics: Adenine; Autophagy; Biomarkers; Cell Line; Chloroquine; Coculture Techniques; Culture Media, Serum-Free; Gene Expression; Genes, Reporter; Green Fluorescent Proteins; Humans; Hydrogen Peroxide; Interleukin-6; Interleukin-8; Macrophages; Macular Degeneration; Microtubule-Associated Proteins; Models, Biological; Oxidative Stress; Phagocytosis; Primary Cell Culture; Retinal Pigment Epithelium; Triamcinolone | 2016 |
Human Rad23A plays a regulatory role in autophagy.
Topics: A549 Cells; Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Cell Proliferation; Cisplatin; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Immunoblotting; Microscopy, Confocal; Microtubule-Associated Proteins; Organoplatinum Compounds; Oxaliplatin; Protein Binding; RNA Interference | 2016 |
Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy.
Topics: Adenine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Autophagy; Cardiotoxicity; Cell Line; Dose-Response Relationship, Drug; Lactic Acid; Membrane Potential, Mitochondrial; Mitoxantrone; Myocytes, Cardiac; Quinoxalines; Rats; Time Factors | 2017 |
Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death.
Topics: Acetylcysteine; Adenine; Animals; Anthracenes; Atrial Natriuretic Factor; Autophagy; Cell Line, Tumor; Cell Proliferation; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Nude; Neoplasm Staging; p38 Mitogen-Activated Protein Kinases; Pyridines; Reactive Oxygen Species; Receptors, Atrial Natriuretic Factor; RNA, Small Interfering; Stomach Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy.
Topics: Adenine; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cisplatin; Docetaxel; Drug Resistance, Neoplasm; Epithelial Cells; Gene Expression Regulation, Neoplastic; Glucuronidase; Humans; Klotho Proteins; Organ Specificity; Respiratory Mucosa; Signal Transduction; Taxoids; Transgenes | 2016 |
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Apoptosis; Autophagy; Beclin-1; Cardiotoxins; Cell Survival; Doxorubicin; L-Lactate Dehydrogenase; Macrolides; Microtubule-Associated Proteins; Myocytes, Cardiac; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2016 |
Inhibition of autophagy sensitises cells to hydrogen peroxide-induced apoptosis: Protective effect of mild thermotolerance acquired at 40°C.
Topics: Adenine; Apoptosis; Autophagy; Beclin-1; Caspases; Cell Line, Tumor; Chromatin Assembly and Disassembly; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Hydrogen Peroxide; Macrolides; Microtubule-Associated Proteins; Mitochondria; Reactive Oxygen Species; Receptors, Death Domain; Signal Transduction; Temperature; Thermotolerance; Time Factors | 2016 |
Autophagy is induced by anti-neutrophil cytoplasmic Abs and promotes neutrophil extracellular traps formation.
Topics: Adenine; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Autophagy; Cells, Cultured; Extracellular Traps; Healthy Volunteers; Humans; Microtubule-Associated Proteins; Neutrophils; Sirolimus | 2016 |
Naringin in Ganshuang Granule suppresses activation of hepatic stellate cells for anti-fibrosis effect by inhibition of mammalian target of rapamycin.
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Drugs, Chinese Herbal; Fibrosis; Flavanones; Hepatic Stellate Cells; Insulin-Like Growth Factor I; Liver; Liver Cirrhosis; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; TOR Serine-Threonine Kinases | 2017 |
Targeting cancer cells through antibiotics-induced mitochondrial dysfunction requires autophagy inhibition.
Topics: Adenine; Adenosine Triphosphate; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Electron Transport Chain Complex Proteins; Energy Metabolism; Female; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Mitochondria; Mitophagy; Reactive Oxygen Species; Signal Transduction; Time Factors; Transfection | 2017 |
P300/CBP-associated factor (PCAF) inhibits the growth of hepatocellular carcinoma by promoting cell autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Female; Gene Knockdown Techniques; Humans; Liver Neoplasms; Macrolides; Mice, Inbred BALB C; Mice, Nude; Oligopeptides; p300-CBP Transcription Factors; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Characterization of substrate binding and enzymatic removal of a 3-methyladenine lesion from genomic DNA with TAG of MDR A. baumannii.
Topics: Acinetobacter baumannii; Adenine; Calorimetry; DNA Glycosylases; DNA Repair; DNA, Bacterial; Genome, Bacterial; Protein Binding; Spectrometry, Fluorescence; Substrate Specificity | 2016 |
Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy.
Topics: Adenine; alpha-MSH; Animals; Autophagy; Cell Survival; Garcinia mangostana; Humans; Inflammation; Melanins; Melanocytes; Melanoma; Melanoma, Experimental; Melanosomes; Mice; Microscopy, Electron, Transmission; Monophenol Monooxygenase; Pigmentation; Plant Extracts; Proteasome Endopeptidase Complex; Seeds; Skin; Skin Neoplasms; Ubiquitin; Xanthones | 2017 |
Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Beclin-1; Biomarkers; Brain Ischemia; Cell Body; Cerebral Cortex; DNA Damage; Folic Acid Deficiency; Male; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Oxidative Stress; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Specific Pathogen-Free Organisms; Up-Regulation | 2016 |
Identification of Cofilin-1 Induces G0/G1 Arrest and Autophagy in Angiotensin-(1-7)-treated Human Aortic Endothelial Cells from iTRAQ Quantitative Proteomics.
Topics: Adenine; Angiotensin I; Aorta; Apoptosis; Autophagy; Biomarkers; Cell Cycle; Cell Proliferation; Cells, Cultured; Cofilin 1; Endothelium, Vascular; G1 Phase; Gene Silencing; Homeostasis; Humans; Peptide Fragments; Proteomics; Resting Phase, Cell Cycle; RNA, Small Interfering | 2016 |
AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Benzofurans; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Mitochondria; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Salvia miltiorrhiza; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Simvastatin alleviates airway inflammation and remodelling through up-regulation of autophagy in mouse models of asthma.
Topics: Adenine; Airway Remodeling; Animals; Asthma; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cytokines; Disease Models, Animal; Extracellular Matrix; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon-gamma; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Myocytes, Smooth Muscle; Ovalbumin; Simvastatin; Up-Regulation | 2017 |
Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo.
Topics: Adenine; Adenylate Kinase; Animals; Apoptosis; Autophagy; Cellular Senescence; Enzyme Activation; Female; Gene Expression Regulation; Intervertebral Disc Degeneration; Male; Metformin; Neuroprotective Agents; Nucleus Pulposus; Oxidative Stress; Rats, Sprague-Dawley; RNA, Small Interfering; tert-Butylhydroperoxide | 2016 |
AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes.
Topics: Adenine; Animals; Autophagosomes; Autophagy; CD11c Antigen; Cytokines; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Interferon Regulatory Factors; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Microscopy, Electron; Microscopy, Fluorescence; RAW 264.7 Cells; RNA Interference; RNA, Small Interfering; Sirolimus; Skin; Wound Healing | 2016 |
Ubenimex attenuates acquired sorafenib resistance in renal cell carcinoma by inhibiting Akt signaling in a lipophagy associated mechanism.
Topics: Adenine; Animals; Autophagy; Carcinoma, Renal Cell; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Leucine; Lipid Metabolism; Mice; Niacinamide; Phenylurea Compounds; Proto-Oncogene Proteins c-akt; Signal Transduction; Sorafenib; Xenograft Model Antitumor Assays | 2016 |
Luteolin Attenuates Foam Cell Formation and Apoptosis in Ox-LDL-Stimulated Macrophages by Enhancing Autophagy.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Autophagy; Azo Compounds; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Beclin-1; Caspase 3; Caspase 9; Cell Differentiation; Cell Line; Foam Cells; Gene Expression Regulation; Lipoproteins, LDL; Luteolin; Macrophage Activation; Macrophages; Mice; Microtubule-Associated Proteins; Signal Transduction | 2016 |
A Novel Role of Dickkopf-Related Protein 3 in Macropinocytosis in Human Bladder Cancer T24 Cells.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Amiloride; Autophagy; Cell Line, Tumor; Cell Proliferation; Chemokines; Epithelial Cells; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intercellular Signaling Peptides and Proteins; Lysosomal Membrane Proteins; MAP Kinase Kinase 4; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Pinocytosis; rab5 GTP-Binding Proteins; rac1 GTP-Binding Protein; RNA, Small Interfering; Signal Transduction; Urinary Bladder | 2016 |
Fusobacterium nucleatum-Induced Impairment of Autophagic Flux Enhances the Expression of Proinflammatory Cytokines via ROS in Caco-2 Cells.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcysteine; Adenine; Animals; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Protein 5; Caco-2 Cells; Cell Line, Tumor; Epithelial Cells; Free Radical Scavengers; Fusobacterium Infections; Fusobacterium nucleatum; Gene Expression Regulation; Humans; Interleukin-1beta; Interleukin-8; Macrolides; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha | 2016 |
A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Mice; Mitogen-Activated Protein Kinase 14; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors | 2017 |
Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells.
Topics: Acetylcysteine; Adenine; Autophagy; Blotting, Western; Cancer-Associated Fibroblasts; Cell Line, Tumor; Cell Proliferation; Cell Survival; Coculture Techniques; Colorectal Neoplasms; Humans; Oxidative Stress | 2017 |
Simulated ischemia/reperfusion-induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells.
Topics: Adenine; Autophagy; Beclin-1; Cell Death; Human Umbilical Vein Endothelial Cells; Humans; Myocardial Reperfusion Injury; Sirolimus; Transcription Factor RelA | 2016 |
Crosstalk of ROS/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro.
Topics: Adenine; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Reactive Nitrogen Species; Reactive Oxygen Species; Silybin; Silymarin; Up-Regulation | 2017 |
Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cell Hypoxia; Cells, Cultured; Endoplasmic Reticulum Stress; Macrophages, Alveolar; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Superoxide Dismutase | 2016 |
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms.
Topics: Adenine; Autophagy; Cell Line, Tumor; Cell Survival; Ceramides; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Glioblastoma; Humans; Oxidoreductases | 2017 |
Systemic application of 3-methyladenine markedly inhibited atherosclerotic lesion in ApoE
Topics: Adenine; Animals; Apolipoproteins E; Apoptosis; Atherosclerosis; Autophagy; Cell Count; Cell Survival; Cellular Microenvironment; Diet, High-Fat; Foam Cells; Lipid Droplets; Lipoproteins, LDL; Macrophages; Male; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Plaque, Atherosclerotic | 2016 |
A functional nanocarrier that copenetrates extracellular matrix and multiple layers of tumor cells for sequential and deep tumor autophagy inhibitor and chemotherapeutic delivery.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Delivery Systems; Extracellular Matrix; Gelatin; Humans; MCF-7 Cells; Melanoma, Experimental; Mice, Inbred C57BL; Nanoparticles; Particle Size; Spheroids, Cellular; Tissue Distribution | 2017 |
Autophagy flux induced by ginsenoside-Rg3 attenuates human prion protein-mediated neurotoxicity and mitochondrial dysfunction.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Ginsenosides; Humans; Mitochondria; Neurons; Prions; Proto-Oncogene Proteins c-akt | 2016 |
Genetic ablation or pharmacologic inhibition of autophagy mitigated NSAID-associated gastric damages.
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; Cell Line; Chloroquine; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gastric Mucosa; Humans; Indomethacin; Male; Microtubule-Associated Proteins; Protective Agents; Rats, Inbred WKY; RNA Interference; RNAi Therapeutics; Stomach; Stomach Ulcer | 2017 |
Valproic acid attenuates renal fibrosis through the induction of autophagy.
Topics: Actins; Adenine; Animals; Autophagy; Cell Line; Collagen Type I; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Fibroblasts; Fibrosis; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Microtubule-Associated Proteins; Rats; Transforming Growth Factor beta1; Ureteral Obstruction; Valproic Acid | 2017 |
Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die.
Topics: Acetylcysteine; Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cells, Cultured; Hippocampus; Ischemia; Leupeptins; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Phosphorylation; Rats; RNA Interference; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Valproic acid protects against MPP
Topics: 1-Methyl-4-phenylpyridinium; Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Humans; Macrolides; Mitochondria; Neuroprotective Agents; Parkinson Disease; Reactive Oxygen Species; Valproic Acid | 2017 |
Carbamylated Low-Density Lipoprotein (cLDL)-Mediated Induction of Autophagy and Its Role in Endothelial Cell Injury.
Topics: Adenine; Atherosclerosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Death; Cells, Cultured; Coronary Vessels; Cytosol; DNA Fragmentation; Endothelial Cells; Humans; L-Lactate Dehydrogenase; Lipids; Lipoproteins, LDL; Microcirculation; Microscopy, Fluorescence; Microtubule-Associated Proteins; Renal Insufficiency, Chronic; RNA, Small Interfering | 2016 |
Glycoconjugated Site-Selective DNA-Methylating Agent Targeting Glucose Transporters on Glioma Cells.
Topics: Adenine; Alkanesulfonates; Antineoplastic Agents, Alkylating; Biological Transport; Cell Line, Tumor; Cell Survival; DNA Adducts; DNA Damage; DNA Methylation; DNA, Neoplasm; Gene Expression; Glucosamine; Glucose Transport Proteins, Facilitative; Glycoconjugates; Humans; Molecular Dynamics Simulation; Molecular Targeted Therapy; Neuroglia; Nucleic Acid Conformation; Pyrroles; Streptozocin | 2017 |
Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Line, Tumor; Cell Proliferation; Female; G1 Phase Cell Cycle Checkpoints; Humans; Proto-Oncogene Proteins c-akt; Pyrimidines; Pyrroles; Receptor, IGF Type 1; RNA, Small Interfering; Signal Transduction; Triple Negative Breast Neoplasms | 2017 |
Increased autophagy in fibroblast-like synoviocytes leads to immune enhancement potential in rheumatoid arthritis.
Topics: Adenine; Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Autophagy; Blotting, Western; Cell Hypoxia; Cell Survival; Cells, Cultured; Chloroquine; Fibroblasts; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-6; Mice, Nude; Microscopy, Fluorescence; Reverse Transcriptase Polymerase Chain Reaction; Synoviocytes | 2017 |
CLOCK Promotes Endothelial Damage by Inducing Autophagy through Reactive Oxygen Species.
Topics: Adenine; Autophagy; Cell Hypoxia; Cell Movement; Cell Proliferation; Cell Survival; CLOCK Proteins; Human Umbilical Vein Endothelial Cells; Humans; Models, Biological; Reactive Oxygen Species | 2016 |
Biomarkers of cigarette smoking and DNA methylating agents: Raman, SERS and DFT study of 3-methyladenine and 7-methyladenine.
Topics: Adenine; Adsorption; Biomarkers; Cigarette Smoking; DNA Methylation; Gold; Metal Nanoparticles; Models, Molecular; Quantum Theory; Spectrophotometry, Ultraviolet; Spectrum Analysis, Raman; Static Electricity; Thermodynamics | 2017 |
Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Caspase 3; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Microtubule-Associated Proteins; Multiple Sclerosis; Neurons; Sirolimus; Spinal Cord | 2017 |
Inhibition of Inositol 1, 4, 5-Trisphosphate Receptor Induce Breast Cancer Cell Death Through Deregulated Autophagy and Cellular Bioenergetics.
Topics: Acetylcysteine; Adenine; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Breast Neoplasms; Cell Death; Cell Line, Tumor; Energy Metabolism; Fluorescent Antibody Technique; Humans; Inositol 1,4,5-Trisphosphate Receptors; Macrolides; MCF-7 Cells; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; RNA, Small Interfering | 2017 |
Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers.
Topics: Adenine; Animals; Autophagy; Blotting, Western; Caco-2 Cells; Cell Line; Claudin-2; Epithelial Cells; Humans; Hydrogen-Ion Concentration; Indoles; Lysosomes; Macrolides; Microscopy, Confocal; Microtubule-Associated Proteins; Purines; Rats; Sequestosome-1 Protein; Tight Junctions; Tumor Necrosis Factor-alpha | 2017 |
Acanthopanax
Topics: Adenine; Amylases; Animals; Autophagy; Eleutherococcus; Male; Pancreatitis; Phosphatidylinositol 3-Kinases; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Taurocholic Acid | 2016 |
The Protective Roles of ROS-Mediated Mitophagy on
Topics: Adenine; Adenosine Triphosphate; Apoptosis; Chromones; Flow Cytometry; Gamma Rays; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iodine Radioisotopes; Membrane Potential, Mitochondrial; Membrane Proteins; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microtubule-Associated Proteins; Mitochondria; Mitophagy; Morpholines; Oxidative Stress; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Tumor Suppressor Proteins | 2016 |
MicroRNA-410 regulates autophagy-related gene ATG16L1 expression and enhances chemosensitivity via autophagy inhibition in osteosarcoma.
Topics: Adenine; Adult; Antineoplastic Agents; Autophagy; Autophagy-Related Proteins; Biomarkers; Bone Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MicroRNAs; Neoplasm Staging; Osteosarcoma; RNA Interference; Tumor Burden; Young Adult | 2017 |
1,25(OH)
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Calcitriol; Carrier Proteins; Diet, High-Fat; Fatty Acids, Nonesterified; Fatty Liver; Gene Silencing; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Calcitriol; RNA, Small Interfering; Up-Regulation | 2017 |
Autophagy induced by DAMPs facilitates the inflammation response in lungs undergoing ischemia-reperfusion injury through promoting TRAF6 ubiquitination.
Topics: Adenine; Animals; Autophagy; Beclin-1; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chaperonin 60; HMGB1 Protein; Inflammation; Interleukin-6; Lung; Macrophages, Alveolar; Reperfusion Injury; Signal Transduction; Swine; TNF Receptor-Associated Factor 6; Tumor Necrosis Factor-alpha; Ubiquitination | 2017 |
Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Line, Tumor; Endoplasmic Reticulum Stress; Female; Humans; Mice; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Proteins; Ovarian Neoplasms; Quercetin; Random Allocation; RNA, Small Interfering; Signal Transduction; Specific Pathogen-Free Organisms; STAT3 Transcription Factor; Taurochenodeoxycholic Acid; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2017 |
Autophagy Induced by CX-4945, a Casein Kinase 2 Inhibitor, Enhances Apoptosis in Pancreatic Cancer Cell Lines.
Topics: Adenine; Apoptosis; Autophagy; Casein Kinase II; Cell Cycle; Cell Line, Tumor; Cell Survival; G2 Phase Cell Cycle Checkpoints; Humans; Naphthyridines; Pancreatic Neoplasms; Phenazines; RNA Interference | 2017 |
Cobalt chloride treatment induces autophagic apoptosis in human glioma cells via a p53-dependent pathway.
Topics: Adenine; Antimutagenic Agents; Apoptosis; Autophagy; Brain Neoplasms; Caspase 3; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Cobalt; Glioma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Sirolimus; Tumor Suppressor Protein p53 | 2017 |
Autophagy Activation by Rapamycin Before Hypoxia-Reoxygenation Reduces Endoplasmic Reticulum Stress in Alveolar Epithelial Cells.
Topics: Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Beclin-1; Cell Hypoxia; Cell Line; Endoplasmic Reticulum Stress; Immunohistochemistry; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microtubule-Associated Proteins; Oxygen; Rats; Sirolimus; Transcription Factor CHOP; X-Box Binding Protein 1 | 2017 |
Heat Acclimation Regulates the Autophagy-Lysosome Function to Protect Against Heat Stroke-Induced Brain Injury in Mice.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Brain Injuries; Cathepsin B; Cerebral Cortex; Heat Stroke; Hot Temperature; Lysosomal Membrane Proteins; Lysosomes; Mice; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microtubule-Associated Proteins; Survival Rate | 2017 |
Staphylococcal lipoteichoic acid promotes osteogenic differentiation of mouse mesenchymal stem cells by increasing autophagic activity.
Topics: Actins; Adenine; Alkaline Phosphatase; Animals; Autophagy; Blotting, Western; Cell Differentiation; Cell Line; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Gene Expression; Immunosuppressive Agents; Lipopolysaccharides; Mesenchymal Stem Cells; Mice, Inbred C3H; Microtubule-Associated Proteins; Osteogenesis; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus; Staphylococcus aureus; Teichoic Acids | 2017 |
Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy.
Topics: 3-Hydroxybutyric Acid; Adenine; Aged; Aged, 80 and over; Animals; Autophagy; Cell Line, Tumor; Cells, Cultured; Chemokine CXCL12; Fibroblasts; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Protein Phosphatase 2; Reactive Oxygen Species; TOR Serine-Threonine Kinases | 2017 |
Autophagy inhibitor 3-methyladenine alleviates overload-exercise-induced cardiac injury in rats.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Heart Injuries; Male; Physical Conditioning, Animal; Rats; Rats, Sprague-Dawley | 2017 |
Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line; Chloroquine; Gene Knockdown Techniques; Humans; Hydrogen Peroxide; Hydroquinones; Microtubule-Associated Proteins; Poly (ADP-Ribose) Polymerase-1; Sirolimus; Sirtuin 1 | 2017 |
Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Chloroquine; Diet, High-Fat; Humans; Infertility, Male; Male; Mice; Mice, Inbred C57BL; Obesity; Palmitic Acid; Semen Analysis; Sirolimus; Spermatogenesis; Spermatozoa; Testis | 2017 |
Induction of Atypical Autophagy by Porcine Hemagglutinating Encephalomyelitis Virus Contributes to Viral Replication.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Betacoronavirus 1; Cell Line; Cell Survival; Chloroquine; Coronavirus Infections; Lysosomes; Membrane Proteins; Mice; Sirolimus; Vacuoles; Virus Replication | 2017 |
Akr1 attenuates methylmercury toxicity through the palmitoylation of Meh1 as a subunit of the yeast EGO complex.
Topics: Acyltransferases; Adenine; Lipoylation; Membrane Proteins; Methylmercury Compounds; Monomeric GTP-Binding Proteins; Mutagenesis, Site-Directed; Protein Binding; Protein Subunits; Saccharomyces cerevisiae Proteins; Transcription Factors; Vacuoles | 2017 |
Role of autophagy in the progression of osteoarthritis: The autophagy inhibitor, 3-methyladenine, aggravates the severity of experimental osteoarthritis.
Topics: Adenine; Animals; Autophagy; Beclin-1; Biomarkers; Cartilage, Articular; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Disease Progression; Gene Expression; Humans; Interleukin-1beta; Male; Matrix Metalloproteinase 13; Microtubule-Associated Proteins; Osteoarthritis; Rabbits; Tissue Inhibitor of Metalloproteinase-1 | 2017 |
Effects of autophagy and endocytosis on the activity of matrix metalloproteinase‑2 in human renal proximal tubular cells under hypoxia.
Topics: Adenine; Autophagy; Cell Hypoxia; Cell Line; Collagen Type IV; Endocytosis; Enzyme-Linked Immunosorbent Assay; Filipin; Humans; Kidney Tubules, Proximal; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; RNA, Messenger | 2017 |
Hypoxic preconditioning-induced autophagy enhances survival of engrafted endothelial progenitor cells in ischaemic limb.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Survival; Cells, Cultured; Endothelial Progenitor Cells; Hindlimb; Hypoxia; Ischemia; Ischemic Preconditioning; Rats, Sprague-Dawley; Stem Cell Transplantation; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 7; Biomarkers; Cell Differentiation; Cell Line; Cisplatin; Epithelial Cells; Exosomes; Female; Fetus; Fibroblasts; Gene Expression; Humans; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Nephritis; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Sirolimus; Umbilical Cord | 2017 |
Near-infrared photothermal therapy using EGFR-targeted gold nanoparticles increases autophagic cell death in breast cancer.
Topics: Adenine; Animals; Antibodies; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line, Tumor; ErbB Receptors; Female; Gold; Humans; Infrared Rays; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microtubule-Associated Proteins; Phototherapy; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Triple Negative Breast Neoplasms | 2017 |
Puerarin attenuates myocardial hypoxia/reoxygenation injury by inhibiting autophagy via the Akt signaling pathway.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Biomarkers; Cell Survival; Disease Models, Animal; Female; Isoflavones; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Vasodilator Agents | 2017 |
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system.
Topics: Adenine; Animals; Bortezomib; Coumarins; Cytochrome P-450 CYP2B6; Down-Regulation; HeLa Cells; Hepatocytes; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Proteasome Endopeptidase Complex; Proteolysis; Rats; Ubiquitin; Ubiquitination | 2017 |
Autophagy-related protein 12 associates with anti-apoptotic B cell lymphoma-2 to promote apoptosis in gentamicin-induced inner ear hair cell loss.
Topics: Adenine; Animals; Apoptosis; Autophagy-Related Protein 12; Cochlea; Female; Gentamicins; Hair Cells, Auditory, Inner; Male; Mice; Models, Biological; Protective Agents; Protein Binding; Proto-Oncogene Proteins c-bcl-2 | 2017 |
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Topics: Adenine; Apoptosis; Autophagy; Bcl-2-Like Protein 11; Cell Line; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Glucose; Humans; Kidney Tubules, Proximal; RNA, Small Interfering | 2017 |
Autophagy plays beneficial effect on diabetic encephalopathy in type 2 diabetes: studies in vivo and in vitro.
Topics: Adenine; Animals; Arcuate Nucleus of Hypothalamus; Autophagy; Blotting, Western; Brain Diseases; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Down-Regulation; Glucose Tolerance Test; Hypothalamus; Immunosuppressive Agents; In Vitro Techniques; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Lipid Metabolism; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neurons; Oleic Acid; PC12 Cells; Rats; Receptor, Insulin; Sirolimus; TOR Serine-Threonine Kinases; Up-Regulation; Ventromedial Hypothalamic Nucleus | 2017 |
Autophagy induction regulates influenza virus replication in a time-dependent manner.
Topics: Adenine; Animals; Autophagy; Beclin-1; Dogs; Hemagglutinins; Influenza A virus; Madin Darby Canine Kidney Cells; Orthomyxoviridae Infections; Transfection; Viral Load; Virus Replication | 2017 |
Autophagy Activation Alleviates Amyloid-β-Induced Oxidative Stress, Apoptosis and Neurotoxicity in Human Neuroblastoma SH-SY5Y Cells.
Topics: Adenine; Amyloid beta-Peptides; Apoptosis; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclic AMP Response Element-Binding Protein; Humans; Membrane Potential, Mitochondrial; Neural Cell Adhesion Molecules; Neurons; Neuroprotection; Oxidative Stress; Peptide Fragments; Real-Time Polymerase Chain Reaction; Sirolimus | 2017 |
Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cell Line, Tumor; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Stomach Neoplasms; TOR Serine-Threonine Kinases | 2017 |
Inhibition of cell proliferation and induction of autophagy by KDM2B/FBXL10 knockdown in gastric cancer cells.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; F-Box Proteins; Gene Knockdown Techniques; Humans; Jumonji Domain-Containing Histone Demethylases; Mice, SCID; Phosphatidylinositol 3-Kinases; Prognosis; Proto-Oncogene Proteins c-akt; Stomach Neoplasms; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2017 |
The PNPLA3 variant associated with fatty liver disease (I148M) accumulates on lipid droplets by evading ubiquitylation.
Topics: Adenine; Animals; Caloric Restriction; Dietary Sucrose; Fatty Liver; Genetic Predisposition to Disease; Lipid Droplets; Lipid Metabolism; Mice, Transgenic; Oxidation-Reduction; Phospholipases A2, Calcium-Independent; Proteasome Endopeptidase Complex; Triglycerides; Ubiquitination | 2017 |
Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer.
Topics: Adenine; Animals; Autophagy; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Cytochromes c; Drug Synergism; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Macrolides; Mice; Mice, Nude; Mitochondria; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2017 |
Caveolin-1-Autophagy Pathway Mediated Cardiomyocyte Hypertrophy Induced by Apelin-13.
Topics: Adenine; Animals; Aorta, Abdominal; Apelin Receptors; Autophagosomes; Autophagy; Beclin-1; Caveolin 1; Cell Line; Disease Models, Animal; Hypertrophy, Left Ventricular; Intercellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Myocytes, Cardiac; Natriuretic Peptide, Brain; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled | 2017 |
CNOT2 promotes degradation of p62/SQSTM1 as a negative regulator in ATG5 dependent autophagy.
Topics: Adenine; Adipogenesis; Ammonium Chloride; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Cycle; Cell Differentiation; Chloroquine; HEK293 Cells; Humans; Repressor Proteins; RNA-Binding Proteins; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; Ubiquitination; Up-Regulation | 2017 |
Autophagy-regulated AMPAR subunit upregulation in in vitro oxygen glucose deprivation/reoxygenation-induced hippocampal injury.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Hypoxia; Cell Survival; Cells, Cultured; Glucose; Hippocampus; Neurons; Oxygen; Rats, Sprague-Dawley; Receptors, AMPA; Reperfusion Injury; Transcriptional Activation | 2017 |
RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems.
Topics: Adenine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Drug Resistance, Neoplasm; Furans; Glutathione; Head and Neck Neoplasms; Humans; Kelch-Like ECH-Associated Protein 1; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-E2-Related Factor 2; Oxidative Stress; Proto-Oncogene Proteins c-myc | 2017 |
TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Nude; Microtubule-Associated Proteins; RNA, Small Interfering; Signal Transduction; Taxoids; TOR Serine-Threonine Kinases; TRPC Cation Channels; Xenograft Model Antitumor Assays | 2017 |
Roflupram, a Phosphodiesterase 4 Inhibitior, Suppresses Inflammasome Activation through Autophagy in Microglial Cells.
Topics: Adenine; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Protein 7; Benzene Derivatives; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Evaluation, Preclinical; Female; Furans; Gene Expression Regulation; Inflammasomes; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Microtubule-Associated Proteins; Molecular Structure; Peptide Fragments; Phosphodiesterase 4 Inhibitors; Random Allocation; RNA Interference; RNA, Small Interfering; Sequestosome-1 Protein | 2017 |
Allospecific Memory B Cell Responses Are Dependent on Autophagy.
Topics: Adenine; Animals; Antibodies, Monoclonal; Autophagy; Autophagy-Related Protein 7; B-Lymphocytes; Heart Transplantation; Immunologic Memory; Isoantibodies; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Transplantation, Homologous | 2018 |
Acquired inhibition of microRNA-124 protects against spinal cord ischemia-reperfusion injury partially through a mitophagy-dependent pathway.
Topics: Adenine; Animals; Apoptosis; Beclin-1; Disease Models, Animal; Genetic Vectors; Lentivirus; Male; MicroRNAs; Microtubule-Associated Proteins; Mitophagy; Motor Neurons; Neuroprotective Agents; Rats; Reperfusion Injury; Spinal Cord Ischemia | 2017 |
Autophagy can alleviate severe burn-induced damage to the intestinal tract in mice.
Topics: Adenine; Animals; Autophagy; Burns; Disease Models, Animal; Female; Interleukin-6; Intestinal Mucosa; Intestines; Male; Mice; Sirolimus; Tumor Necrosis Factor-alpha | 2017 |
Inhibition of autophagy by berberine enhances the survival of H9C2 myocytes following hypoxia.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; bcl-2-Associated X Protein; Berberine; Caspase 3; Cell Hypoxia; Cell Line; Cell Survival; Microtubule-Associated Proteins; Myocytes, Cardiac; Pinellia; Rats; Sirolimus | 2017 |
Autophagy suppresses isoprenaline-induced M2 macrophage polarization via the ROS/ERK and mTOR signaling pathway.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Cell Line, Tumor; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoproterenol; Lung Neoplasms; Mammary Neoplasms, Experimental; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; RAW 264.7 Cells; Reactive Oxygen Species; Sirolimus; STAT3 Transcription Factor; TOR Serine-Threonine Kinases; Tumor Microenvironment | 2017 |
Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux.
Topics: Adenine; Adipocytes; Adipose Tissue; Animals; Autophagosomes; Autophagy; Cell Line; Culture Media, Conditioned; Lipid Droplets; Lysosomes; Macrophages; Male; Mice; Mice, Inbred C57BL; Obesity; Oleic Acid; Phagocytosis; RAW 264.7 Cells | 2017 |
Involvement of autophagy in tantalum nanoparticle-induced osteoblast proliferation.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Proliferation; Cell Survival; Mice; Nanoparticles; Osteoblasts; Porosity; Prostheses and Implants; Tantalum | 2017 |
Mono-(2-ethylhexyl) phthalate induced ROS-dependent autophagic cell death in human vascular endothelial cells.
Topics: Acetylcysteine; Adenine; Autophagy; Cell Line; Cell Survival; Diethylhexyl Phthalate; Endothelial Cells; Humans; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Small Interfering; Sirolimus | 2017 |
Baicalein Protects against Rotenone-Induced Neurotoxicity through Induction of Autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopamine; Flavanones; Homeostasis; Humans; Insecticides; Male; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Neurotoxicity Syndromes; Parkinson Disease; Phytotherapy; Plant Extracts; Reactive Oxygen Species; Rotenone; Scutellaria baicalensis | 2017 |
TGF-β1 promotes human hepatic carcinoma HepG2 cells invasion by upregulating autophagy.
Topics: Adenine; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver Neoplasms; Microtubule-Associated Proteins; Neoplasm Invasiveness; Transforming Growth Factor beta1; Up-Regulation | 2017 |
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy.
Topics: Adenine; Angiogenesis Inhibitors; Animals; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Proto-Oncogene Proteins c-akt; Ranibizumab; Reactive Oxygen Species; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Retinal Pigment Epithelium; Sirolimus; Swine | 2017 |
Autophagy inhibits high glucose induced cardiac microvascular endothelial cells apoptosis by mTOR signal pathway.
Topics: Adenine; Animals; Apoptosis; Caspases; Cells, Cultured; Endothelial Cells; Glucose; Heart; Male; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2017 |
Effect of Multipurpose Solution Combined With Autophagy Inhibitors on Adhesion of Acanthamoeba trophozoites to Silicone Hydrogel Contact Lenses.
Topics: Acanthamoeba castellanii; Adenine; Amebicides; Autophagy; Bacterial Adhesion; Chloroquine; Contact Lens Solutions; Contact Lenses, Hydrophilic; Hydrogel, Polyethylene Glycol Dimethacrylate; Microscopy, Electron; Silicones; Trophozoites | 2017 |
Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons.
Topics: Adenine; Aldehydes; Animals; Autophagy; Cells, Cultured; Energy Metabolism; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Neurons; Oxidative Stress; Primary Cell Culture; Rats | 2017 |
Down-Regulation of Lncrna MALAT1 Attenuates Neuronal Cell Death Through Suppressing Beclin1-Dependent Autophagy by Regulating Mir-30a in Cerebral Ischemic Stroke.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Glucose; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; MicroRNAs; Neurons; Oxygen; RNA Interference; RNA, Long Noncoding; Stroke; Up-Regulation | 2017 |
Autophagy inhibitors suppress environmental particulate matter-induced airway inflammation.
Topics: Adenine; Animals; Autophagy; Benzylamines; Cell Line; Cytokines; Environmental Pollutants; Gene Expression Regulation; Humans; Inflammation; Mice; Mice, Inbred C57BL; Particulate Matter; Quinazolines | 2017 |
Ex vivo 3D human corneal stroma model for Schnyder corneal dystrophy - role of autophagy in its pathogenesis and resolution.
Topics: Adenine; Adult; Aged; Autophagy; Cadaver; Cells, Cultured; Cornea; Corneal Dystrophies, Hereditary; Corneal Stroma; Extracellular Matrix; Fluorescent Antibody Technique; Humans; Imaging, Three-Dimensional; Inclusion Bodies; Mesenchymal Stem Cells; Microscopy, Electron, Transmission; Middle Aged; Models, Anatomic | 2018 |
HSF1 upregulates ATG4B expression and enhances epirubicin-induced protective autophagy in hepatocellular carcinoma cells.
Topics: Adenine; Animals; Antibiotics, Antineoplastic; Autophagy; Autophagy-Related Proteins; Carcinoma, Hepatocellular; Cell Line, Tumor; Chloroquine; Cysteine Endopeptidases; DNA-Binding Proteins; Drug Synergism; Epirubicin; Heat Shock Transcription Factors; Hep G2 Cells; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; RNA, Messenger; Transcription Factors; Transfection; Up-Regulation; Xenograft Model Antitumor Assays | 2017 |
Suppression of FoxO3a attenuates neurobehavioral deficits after traumatic brain injury through inhibiting neuronal autophagy.
Topics: Adenine; Adult; Animals; Autophagy; Brain Injuries, Traumatic; Case-Control Studies; Disease Models, Animal; Female; Forkhead Box Protein O3; Humans; Male; Maze Learning; Mental Disorders; Neurons; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Retrospective Studies; RNA, Small Interfering; Signal Transduction | 2018 |
Detrimental effect of Hypoxia-inducible factor-1α-induced autophagy on multiterritory perforator flap survival in rats.
Topics: Adenine; Amino Acids, Dicarboxylic; Animals; Autophagy; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Perforator Flap; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation | 2017 |
Isoliquiritigenin Induces Autophagy and Inhibits Ovarian Cancer Cell Growth.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; bcl-2-Associated X Protein; Beclin-1; Caspase 3; Cell Line, Tumor; Cell Survival; Chalcones; Dose-Response Relationship, Drug; Female; G2 Phase Cell Cycle Checkpoints; Humans; Microtubule-Associated Proteins; Ovary; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Sequestosome-1 Protein | 2017 |
Autophagy is activated to protect renal tubular epithelial cells against iodinated contrast media‑induced cytotoxicity.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 7; Cell Survival; Contrast Media; Epithelial Cells; Flow Cytometry; Gene Expression Regulation; Humans; Iodine Compounds; Iohexol; Kidney Tubules; Protective Agents | 2017 |
Globular Adiponectin Attenuated H2O2-Induced Apoptosis in Rat Chondrocytes by Inducing Autophagy Through the AMPK/ mTOR Pathway.
Topics: Adenine; Adiponectin; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; bcl-2-Associated X Protein; Caspase 3; Cell Survival; Cells, Cultured; Chondrocytes; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Microscopy, Fluorescence; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction; TOR Serine-Threonine Kinases | 2017 |
Cytokine-induced autophagy promotes long-term VCAM-1 but not ICAM-1 expression by degrading late-phase IκBα.
Topics: Adenine; Autophagy; Cell Nucleus; Chemokine CXCL10; Coculture Techniques; Cytoplasm; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Intercellular Adhesion Molecule-1; Interleukin-1beta; Jurkat Cells; NF-KappaB Inhibitor alpha; Protein Transport; Proteolysis; Signal Transduction; Transcription Factor RelA; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2017 |
Autophagy protects auditory hair cells against neomycin-induced damage.
Topics: Acetylcysteine; Adenine; Animals; Anti-Bacterial Agents; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Line; Hair Cells, Auditory; Mice; Mitochondria; Neomycin; Reactive Oxygen Species; Sirolimus | 2017 |
Fangchinoline Induces Apoptosis, Autophagy and Energetic Impairment in Bladder Cancer.
Topics: Adenine; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Autophagy; Benzylisoquinolines; Caspase 3; Cell Line, Tumor; Cell Survival; Humans; Microtubule-Associated Proteins; Proliferating Cell Nuclear Antigen; Pyruvates; RNA-Binding Proteins; Stephania tetrandra; TOR Serine-Threonine Kinases; Urinary Bladder Neoplasms | 2017 |
High magnesium prevents matrix vesicle-mediated mineralization in human bone marrow-derived mesenchymal stem cells via mitochondrial pathway and autophagy.
Topics: Adenine; Adenosine Triphosphate; Autophagy; Bone Marrow Cells; Calcification, Physiologic; Calcium; Cells, Cultured; Extracellular Vesicles; Humans; Magnesium; Mesenchymal Stem Cells; Mitochondria | 2018 |
Protective effect of autophagy in neural ischemia and hypoxia: Negative regulation of the Wnt/β-catenin pathway.
Topics: Adenine; Animals; Autophagy; beta Catenin; Hypoxia-Ischemia, Brain; Models, Biological; Morpholines; PC12 Cells; Rats; Sirolimus; Triazines; Wnt Signaling Pathway | 2017 |
Gambogic acid improves non-small cell lung cancer progression by inhibition of mTOR signaling pathway.
Topics: A549 Cells; Adenine; Antineoplastic Agents, Phytogenic; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Cisplatin; Drug Combinations; Drug Synergism; Garcinia; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Plant Extracts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Xanthones | 2017 |
Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.
Topics: Adenine; Alkylation; Amino Acid Sequence; Bacillus cereus; Catalytic Domain; Crystallography, X-Ray; DNA Adducts; DNA Damage; DNA Glycosylases; DNA Repair; Models, Molecular; Protein Conformation; Sequence Homology | 2018 |
Ketogenic diet attenuates neuronal injury via autophagy and mitochondrial pathways in pentylenetetrazol-kindled seizures.
Topics: Adenine; Animals; Apoptosis; Autophagy; Caspase 3; Cytochromes c; Diet, Ketogenic; Epilepsy; Hippocampus; Male; Mitochondria; Neurons; Neuroprotective Agents; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Sirolimus | 2018 |
Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury.
Topics: Acute Lung Injury; Adenine; Adherens Junctions; Animals; Autophagy; Capillary Permeability; Cells, Cultured; Endothelium, Vascular; Humans; Male; Mice; Mice, Inbred C57BL; Pulmonary Artery | 2018 |
Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes.
Topics: Adenine; Aged; Animals; Autophagy; CCAAT-Enhancer-Binding Proteins; Cell Line; Epithelial Cells; Female; Genes, Mitochondrial; Humans; Lung; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mitochondria; NADH Dehydrogenase; Particulate Matter; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Taurine | 2017 |
[TLR2 modulates Staphylococcus aureus-induced inflammatory response and autophagy in macrophages through PI3K signaling pathway].
Topics: Adenine; Animals; Autophagy; Cells, Cultured; Inflammation; Macrophages; Mice; Phosphatidylinositol 3-Kinases; Signal Transduction; Staphylococcus aureus; Toll-Like Receptor 2; Transcription Factor RelA | 2017 |
Deferoxamine-Induced Migration and Odontoblast Differentiation via ROS-Dependent Autophagy in Dental Pulp Stem Cells.
Topics: Adenine; Adolescent; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Deferoxamine; Dental Pulp; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Macrolides; Membrane Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Odontoblasts; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Stem Cells; Young Adult | 2017 |
Trolline Ameliorates Liver Fibrosis by Inhibiting the NF-κB Pathway, Promoting HSC Apoptosis and Suppressing Autophagy.
Topics: Adenine; Alkaloids; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; bcl-2-Associated X Protein; Beclin-1; Carbon Tetrachloride; Cell Line; Collagen; Cytokines; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Signal Transduction | 2017 |
Lipopolysaccharide (LPS)-Induced Autophagy Is Responsible for Enhanced Osteoclastogenesis.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cells, Cultured; Cytoplasm; Lipopolysaccharides; Macrophages; Mice; Osteoclasts; Osteogenesis; Reactive Oxygen Species | 2017 |
Resveratrol transcriptionally regulates miRNA-18a-5p expression ameliorating diabetic nephropathy via increasing autophagy.
Topics: Adenine; Animals; Ataxia Telangiectasia Mutated Proteins; Autophagy; Caspase 3; Cell Line; Creatinine; Diabetes Mellitus, Experimental; Down-Regulation; Male; Mice; Mice, Obese; MicroRNAs; Microtubule-Associated Proteins; Resveratrol; RNA Interference; RNA, Small Interfering; Sirolimus; Stilbenes; Up-Regulation | 2017 |
Porcine teschovirus 2 induces an incomplete autophagic response in PK-15 cells.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 5; Cell Line; Epithelial Cells; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Host-Pathogen Interactions; Kidney; Microtubule-Associated Proteins; RNA, Small Interfering; Signal Transduction; Sirolimus; Swine; Teschovirus; Virus Replication; Wortmannin | 2018 |
Isogambogenic Acid Inhibits the Growth of Glioma Through Activation of the AMPK-mTOR Pathway.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Signal Transduction; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Xanthones | 2017 |
Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization.
Topics: Adenine; alpha-Synuclein; Animals; Apoptosis; Autophagy; Brain; Butylamines; Chlorides; Endoplasmic Reticulum Stress; Environmental Pollutants; Manganese; Manganese Compounds; Mice, Inbred C57BL; Neurons; Phenylbutyrates; Polymerization; Signal Transduction; Sirolimus | 2018 |
Inhibition of autophagy in hepatocarcinoma cells promotes chemotherapeutic agent-induced apoptosis during nutrient deprivation.
Topics: Adenine; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Cisplatin; Fluorouracil; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria | 2018 |
A role for autophagy in long-term spatial memory formation in male rodents.
Topics: Adenine; Animals; Antigens, Nuclear; Autophagy; Beclin-1; Benzylamines; Glial Fibrillary Acidic Protein; Hippocampus; Male; Maze Learning; Memory, Long-Term; Memory, Short-Term; Mice; Microtubule-Associated Proteins; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinase; Phosphorylation; Quinazolines; Rats; Rats, Long-Evans; Spatial Memory | 2018 |
Helicobacter pylori VacA induces autophagic cell death in gastric epithelial cells via the endoplasmic reticulum stress pathway.
Topics: Activating Transcription Factor 4; Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Bacterial Proteins; Cell Cycle Proteins; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Epithelial Cells; Eukaryotic Initiation Factor-2; Gene Expression Regulation, Neoplastic; Helicobacter pylori; Humans; Macrolides; Mice; Poly (ADP-Ribose) Polymerase-1; Protein Serine-Threonine Kinases; Repressor Proteins; RNA, Small Interfering; Signal Transduction; Thapsigargin; Transcription Factor CHOP; Vacuoles | 2017 |
MiR-181a mediates Ang II-induced myocardial hypertrophy by mediating autophagy.
Topics: Adenine; Angiotensin II; Animals; Autophagy; Autophagy-Related Protein 5; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Down-Regulation; Male; MicroRNAs; Microtubule-Associated Proteins; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley | 2017 |
Autophagy: A new treatment strategy for MSC-based therapy in acute kidney injury (Review).
Topics: Acute Kidney Injury; Adenine; Animals; Autophagy; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Reperfusion Injury; TOR Serine-Threonine Kinases | 2018 |
Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Disease Models, Animal; Genotype; In Situ Nick-End Labeling; Mice; Motor Neurons; Muscular Atrophy, Spinal; Sirolimus | 2017 |
1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate induced autophagic cell death in human PC3 cells.
Topics: Acetylcysteine; Adenine; Anthraquinones; Apoptosis; Autophagy; Caspase 3; Cell Line, Tumor; G1 Phase Cell Cycle Checkpoints; Humans; Macrolides; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Reactive Oxygen Species | 2018 |
Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy.
Topics: Adenine; Animals; Anti-Inflammatory Agents; Autophagy; Cartilage, Articular; Cell Survival; Chemokine CCL2; Chondrocytes; Gene Expression Regulation; Interleukin-1beta; Interleukin-6; Male; Models, Biological; Osteoarthritis; Phenylethyl Alcohol; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirtuins; Tumor Necrosis Factor-alpha | 2018 |
Autophagy involved in the activation of the Nrf2-antioxidant system in testes of heat-exposed mice.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Heat-Shock Response; Hot Temperature; Male; Mice; NF-E2-Related Factor 2; Seminiferous Tubules; Sequestosome-1 Protein; Signal Transduction; Sirolimus | 2018 |
Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway.
Topics: Adenine; Animals; Autophagy; Beclin-1; Carcinogens; Cell Aggregation; Cell Differentiation; Cell Line, Tumor; Chloroquine; Cytokines; Endocytosis; Extracellular Matrix; Gelatin; Humans; Macrophages; Mannose-Binding Lectins; Membrane Glycoproteins; Monocytes; Pseudopodia; Receptors, Cell Surface; RNA Interference; Skin; Sus scrofa; Tetradecanoylphorbol Acetate | 2018 |
Exendin-4 impairs the autophagic flux to induce apoptosis in pancreatic acinar AR42J cells by down-regulating LAMP-2.
Topics: Acinar Cells; Adenine; Amino Acid Chloromethyl Ketones; Animals; Autophagy; Caspase 3; Cathepsin B; Cathepsin L; Cell Line; Diabetes Mellitus, Experimental; Diet, High-Fat; Exenatide; Gene Expression Regulation; Lysosomal-Associated Membrane Protein 2; Macrolides; Male; Microtubule-Associated Proteins; Pancreas; Peptides; Rats; Rats, Sprague-Dawley; Sequestosome-1 Protein; Signal Transduction; Streptozocin; Venoms | 2018 |
Propofol postconditioning protects H9c2 cells from hypoxia/reoxygenation injury by inducing autophagy via the SAPK/JNK pathway.
Topics: Adenine; Animals; Anthracenes; Autophagy; Cell Hypoxia; JNK Mitogen-Activated Protein Kinases; L-Lactate Dehydrogenase; MAP Kinase Signaling System; Microtubule-Associated Proteins; Myocytes, Cardiac; Oxygen; Phosphorylation; Propofol; Rats; Sequestosome-1 Protein | 2018 |
Anti-tumor effects of triptolide on angiogenesis and cell apoptosis in osteosarcoma cells by inducing autophagy via repressing Wnt/β-Catenin signaling.
Topics: Adenine; Antineoplastic Agents, Alkylating; Apoptosis; Autophagy; beta Catenin; Cell Line, Tumor; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lithium Chloride; Osteoblasts; Phenanthrenes; Signal Transduction; Vascular Endothelial Growth Factor A | 2018 |
Autophagy inhibition promotes phagocytosis of macrophage and protects mice from methicillin-resistant staphylococcus aureus pneumonia.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Macrophages; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Phagocytosis; Pneumonia, Staphylococcal; RAW 264.7 Cells | 2018 |
Low-dose dexamethasone affects osteoblast viability by inducing autophagy via intracellular ROS.
Topics: Adenine; Apoptosis; Autophagy; Beclin-1; Biomarkers; Catalase; Cell Line; Cell Survival; Dexamethasone; Fetus; Gene Expression; Glucocorticoids; Hormesis; Humans; Microtubule-Associated Proteins; Osteoblasts; Reactive Oxygen Species; Sirolimus | 2018 |
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Biphenyl Compounds; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Fluorouracil; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lignans; Macrolides; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mouth Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Triggering of Autophagy by Baicalein in Response to Apoptosis after Spinal Cord Injury: Possible Involvement of the PI3K Activation.
Topics: Adenine; Animals; Anterior Horn Cells; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Autophagy; Behavior, Animal; Enzyme Activation; Enzyme Inhibitors; Flavanones; Injections, Intraperitoneal; Locomotion; Male; Mice, Inbred C57BL; Microscopy, Electron, Transmission; Motor Neurons; Nerve Tissue Proteins; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Random Allocation; Sequestosome-1 Protein; Spinal Cord Injuries | 2018 |
Neutrophil Gelatinase-Associated Lipocalin Attenuates Ischemia/Reperfusion Injury in an In Vitro Model via Autophagy Activation.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Survival; Humans; Lipocalin-2; Rats; Reperfusion Injury; Vacuoles | 2018 |
[Inhibition of autophagy initiation stage enhances camptothecin-induced apoptosis in NCI-H1975 cells].
Topics: Adenine; Apoptosis; Autophagy; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Lung Neoplasms; Transforming Growth Factor beta1 | 2017 |
Polysaccharide from Fuzi protects against Ox‑LDL‑induced calcification of human vascular smooth muscle cells by increasing autophagic activity.
Topics: Adenine; Autophagy; Diterpenes; Drugs, Chinese Herbal; Humans; Lipoproteins, LDL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plant Extracts; Polysaccharides; Vascular Calcification | 2018 |
Schisandrin C enhances odontoblastic differentiation through autophagy and mitochondrial biogenesis in human dental pulp cells.
Topics: Adenine; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Differentiation; Cells, Cultured; Cyclooctanes; Dental Pulp; Down-Regulation; Heme Oxygenase-1; Humans; Lignans; Lipopolysaccharides; Microtubule-Associated Proteins; Mitochondria; Molar, Third; Odontoblasts; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polycyclic Compounds; Protoporphyrins | 2018 |
The autophagy inhibitor 3-methyladenine restores sevoflurane anesthesiainduced cognitive dysfunction and neurons apoptosis.
Topics: Adenine; Anesthetics, Inhalation; Animals; Apoptosis; Autophagy; Cognitive Dysfunction; Gene Expression Regulation; Hippocampus; Maze Learning; Methyl Ethers; Mice; Mice, Inbred C57BL; Neurons; Sevoflurane | 2017 |
Upregulation of P63 inhibits chondrocyte autophagy thereby enhancing the malignant progression of osteoarthritis.
Topics: Adenine; Aged; Autophagy; Blotting, Western; Cartilage, Articular; Case-Control Studies; Chondrocytes; Disease Progression; Female; Humans; Male; Microscopy, Electron, Transmission; Middle Aged; Osteoarthritis; Time Factors; Transcription Factors; Transfection; Tumor Suppressor Proteins; Up-Regulation | 2017 |
The novel involvement of podocyte autophagic activity in the pathogenesis of lupus nephritis.
Topics: Adenine; Adolescent; Adult; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Proteins; Case-Control Studies; Cells, Cultured; Disease Models, Animal; Disease Progression; Female; Humans; Lupus Nephritis; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Podocytes; Sirolimus; Young Adult | 2018 |
Inhibition of autophagy enhances DENSpm-induced apoptosis in human colon cancer cells in a p53 independent manner.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; HCT116 Cells; HT29 Cells; Humans; Membrane Potential, Mitochondrial; Polyamines; RNA, Small Interfering; Spermine; Tumor Suppressor Protein p53 | 2018 |
Interplay between autophagy and apoptosis in lead(II)-induced cytotoxicity of primary rat proximal tubular cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cells, Cultured; Kidney Tubules, Proximal; Lead; Microtubule-Associated Proteins; Rats; Sirolimus | 2018 |
Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils.
Topics: Adenine; Adenosine Triphosphate; Autophagy; Autophagy-Related Protein 5; Cell Line; Humans; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Macrolides; Microtubule-Associated Proteins; Neutrophils; Protein Transport; RNA, Small Interfering; Secretory Pathway; Serine Proteases; Wortmannin | 2018 |
Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy.
Topics: Adenine; Adult; Aged; Apoptosis; Autophagy; Cells, Cultured; Deoxyglucose; Endoplasmic Reticulum Stress; Extracellular Matrix; Female; Heat-Shock Proteins; Humans; Intervertebral Disc Degeneration; Male; Middle Aged; Nuclear Proteins; Plasmids; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Secretome of Differentiated PC12 Cells Restores the Monocrotophos-Induced Damages in Human Mesenchymal Stem Cells and SHSY-5Y Cells: Role of Autophagy and Mitochondrial Dynamics.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Cellular Microenvironment; Culture Media, Conditioned; Electrophoresis, Gel, Two-Dimensional; Humans; Mesenchymal Stem Cells; Mitochondrial Dynamics; Monocrotophos; Nerve Tissue Proteins; Neuroblastoma; Neurotoxins; Organelle Biogenesis; Oxidative Stress; PC12 Cells; Protein Translocation Systems; Proteome; Rats | 2018 |
The mTOR Kinase Inhibitor CZ415 Inhibits Human Papillary Thyroid Carcinoma Cell Growth.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Papillary; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cyclic S-Oxides; Female; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, SCID; Phenylurea Compounds; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Substrate Specificity; Thyroid Cancer, Papillary; Thyroid Neoplasms; TOR Serine-Threonine Kinases | 2018 |
Autophagy inhibition enhances radiosensitivity of Eca‑109 cells via the mitochondrial apoptosis pathway.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Chromones; Esophageal Neoplasms; Gene Regulatory Networks; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Morpholines; Radiation Tolerance; Xenograft Model Antitumor Assays | 2018 |
Targeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Carcinoma, Squamous Cell; Cell Proliferation; Cell Survival; Chloroquine; Cyclic S-Oxides; Extracellular Signal-Regulated MAP Kinases; Female; Head and Neck Neoplasms; Humans; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Nude; Phenylurea Compounds; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Transplantation, Heterologous; Tumor Cells, Cultured | 2018 |
Juglone induces apoptosis and autophagy via modulation of mitogen-activated protein kinase pathways in human hepatocellular carcinoma cells.
Topics: Acetylcysteine; Adenine; Amino Acid Chloromethyl Ketones; Androstadienes; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Proliferation; Enzyme Activation; Hep G2 Cells; Humans; Liver Neoplasms; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Naphthoquinones; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Reactive Oxygen Species; Wortmannin | 2018 |
Regulation of Autophagy Affects the Prognosis of Mice with Severe Acute Pancreatitis.
Topics: Adenine; Animals; Autophagy; Caspase 1; Disease Models, Animal; Inflammation; Interleukin-1beta; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Pancreatitis, Acute Necrotizing; Prognosis; Signal Transduction; Treatment Outcome | 2018 |
LPS at low concentration promotes the fracture healing through regulating the autophagy of osteoblasts via NF-κB signal pathway.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Fracture Healing; Lipopolysaccharides; Mice; NF-kappa B; Nitriles; Osteoblasts; Signal Transduction; Sulfones; Transcription Factor RelA | 2018 |
Schwann-Cell Autophagy, Functional Recovery, and Scar Reduction After Peripheral Nerve Repair.
Topics: Adenine; Animals; Autophagy; Cicatrix; Male; Nerve Regeneration; Peripheral Nerve Injuries; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Sirolimus | 2018 |
The biological role of autophagy in regulating and controlling the proliferation of liver cancer cells induced by bufalin.
Topics: Adenine; Autophagy; Beclin-1; Bufanolides; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chloroquine; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Microtubule-Associated Proteins | 2018 |
3-methyadenine attenuates chloroform-induced hepatotoxicity via autophagy activation.
Topics: Adenine; Animals; Autophagy; Chemical and Drug Induced Liver Injury; Chloroform; Cytokines; Disease Models, Animal; Glutathione; Inflammation Mediators; Liver; Male; Malondialdehyde; Mice; Oxidative Stress; Protective Agents | 2018 |
Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis.
Topics: Adenine; Animals; Autophagy; Carrier Proteins; Endotoxemia; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Sepsis; Shock, Septic; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha | 2018 |
Lithium chloride (LiCl) induced autophagy and downregulated expression of transforming growth factor β-induced protein (TGFBI) in granular corneal dystrophy.
Topics: Adenine; Adjuvants, Immunologic; Autophagy; Blotting, Western; Cell Survival; Corneal Dystrophies, Hereditary; Corneal Keratocytes; Down-Regulation; Extracellular Matrix Proteins; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Immunohistochemistry; Lithium Chloride; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Real-Time Polymerase Chain Reaction; Transfection; Transforming Growth Factor beta | 2018 |
Mitophagy Plays a Protective Role in Iodinated Contrast-Induced Acute Renal Tubular Epithelial Cells Injury.
Topics: Acute Kidney Injury; Adenine; Apoptosis; Autophagy; Cell Line; Contrast Media; Epithelial Cells; Humans; Iodine; Iohexol; Kidney Tubules; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondria; Mitophagy; Reactive Oxygen Species; Sirolimus; Triiodobenzoic Acids | 2018 |
Mulberry anthocyanins improves thyroid cancer progression mainly by inducing apoptosis and autophagy cell death.
Topics: Adenine; Anthocyanins; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Chloroquine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Morus; Plant Extracts; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Thyroid Gland; TOR Serine-Threonine Kinases | 2018 |
Expression and role of autophagy-associated p62 (SQSTM1) in multidrug resistant ovarian cancer.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Cell Movement; Drug Resistance, Neoplasm; Female; Humans; Hydroxychloroquine; Immunohistochemistry; Neoplasm Recurrence, Local; Ovarian Neoplasms; Paclitaxel; Sequestosome-1 Protein | 2018 |
Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain.
Topics: Adenine; Animals; Autophagy; Brain; Chemotaxis, Leukocyte; Enzyme Inhibitors; Inflammation; Male; Mice; Mice, Inbred C57BL; Microglia; Peptidoglycan; Phosphoinositide-3 Kinase Inhibitors | 2018 |
Role of Hypoxia-Inducible Factors 1α (HIF1α) in SH-SY5Y Cell Autophagy Induced by Oxygen-Glucose Deprivation.
Topics: Adenine; Apoptosis; Autophagy; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Gene Knockdown Techniques; Glucose; Green Fluorescent Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubule-Associated Proteins; Models, Biological; Oxygen; RNA, Small Interfering; Sirolimus | 2018 |
Glucosamine-Induced Autophagy through AMPK⁻mTOR Pathway Attenuates Lipofuscin-Like Autofluorescence in Human Retinal Pigment Epithelial Cells In Vitro.
Topics: Adenine; Adenylate Kinase; Autophagosomes; Autophagy; Biomarkers; Cells, Cultured; Epithelial Cells; Eye Proteins; Fluorescence; Glucosamine; Humans; Lipofuscin; Models, Biological; Phagocytosis; Retinal Photoreceptor Cell Outer Segment; Retinal Pigment Epithelium; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Resveratrol induces autophagy-dependent apoptosis in HL-60 cells.
Topics: Adenine; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Knockdown Techniques; HL-60 Cells; Humans; Neoplasms; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Resveratrol; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Beclin-1; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Cell Survival; Collagen Type I; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxychloroquine; Lymphatic Metastasis; Mammary Neoplasms, Animal; Mice; Mice, Nude; Mitochondria; Reactive Oxygen Species; Recurrence; RNA, Small Interfering; Signal Transduction | 2018 |
Cold PSM, but not TRAIL, triggers autophagic cell death: A therapeutic advantage of PSM over TRAIL.
Topics: A549 Cells; Adenine; Autophagosomes; Autophagy; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytoplasm; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Multiple Myeloma; Osteosarcoma; Plasma Gases; Reactive Oxygen Species; TNF-Related Apoptosis-Inducing Ligand | 2018 |
By Targeting Atg7 MicroRNA-143 Mediates Oxidative Stress-Induced Autophagy of c-Kit
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Cell Lineage; Disease Models, Animal; Humans; Hydrogen Peroxide; Mice; Mice, Transgenic; MicroRNAs; Myocardial Infarction; Myocardium; Oxidative Stress; Proto-Oncogene Proteins c-kit; Stem Cell Transplantation; Stem Cells | 2018 |
Tacrolimus alleviates Ox-LDL damage through inducing vascular endothelial autophagy.
Topics: Adenine; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Endothelium, Vascular; Humans; Lipoproteins, LDL; Oxidative Stress; Protective Agents; Reactive Oxygen Species; Superoxide Dismutase; Tacrolimus; Up-Regulation | 2018 |
Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components.
Topics: Adenine; Autophagosomes; Autophagy; Cell Line, Tumor; Hepatitis B virus; Heterocyclic Compounds, 2-Ring; Humans; Lysosomes; Membrane Fusion; rab GTP-Binding Proteins; rab7 GTP-Binding Proteins; Thiourea | 2019 |
Autophagy protects bone marrow mesenchymal stem cells from palmitate‑induced apoptosis through the ROS‑JNK/p38 MAPK signaling pathways.
Topics: Adenine; Animals; Apoptosis; Autophagy; Bone Marrow Cells; Cell Survival; Cells, Cultured; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Mesenchymal Stem Cells; Microtubule-Associated Proteins; p38 Mitogen-Activated Protein Kinases; Palmitates; Protein Isoforms; Rats, Sprague-Dawley; Reactive Oxygen Species; Sequestosome-1 Protein; Signal Transduction | 2018 |
Curcumin Promotes Femoral Fracture Healing in a Rat Model by Activation of Autophagy.
Topics: Adenine; Animals; Autophagy; Bone and Bones; Curcumin; Femoral Fractures; Femur; Fracture Healing; Male; Models, Animal; Rats; Rats, Sprague-Dawley; X-Ray Microtomography | 2018 |
Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine.
Topics: Adenine; Animals; CHO Cells; Cricetulus; Female; Gene Expression Profiling; Gene Expression Regulation; Immunoglobulin Fc Fragments; Recombinant Fusion Proteins; Sequence Analysis, RNA; Unfolded Protein Response | 2018 |
Oxidative stress regulates autophagy in cultured muscle cells of patients with chronic obstructive pulmonary disease.
Topics: Adenine; Aged; Ascorbic Acid; Autophagy; Biomarkers; Cells, Cultured; Female; Humans; Male; Microtubule-Associated Proteins; Middle Aged; Muscle Cells; Muscle Fibers, Skeletal; Muscular Atrophy; Myoblasts; Oxidative Stress; Phagosomes; Pulmonary Disease, Chronic Obstructive | 2018 |
Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells.
Topics: Adenine; Apoptosis; Cation Transport Proteins; Cell Line, Tumor; Humans; Lipid Peroxidation; Neuroblastoma; Piperazines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering | 2018 |
Inhibition of autophagy significantly increases the antitumor effect of Abiraterone in prostate cancer.
Topics: Abiraterone Acetate; Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Death; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Humans; Male; Prostatic Neoplasms, Castration-Resistant | 2019 |
Hypoxia induces autophagy in PA-l ovarian teratoma cells and resistance to growth inhibition and apoptosis by chemotherapeutic agent cis-diamminedichloroplatinum.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein 5; Autophagy-Related Protein 8 Family; Beclin-1; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Female; Humans; Microtubule-Associated Proteins; Ovarian Neoplasms; Teratoma; Tumor Microenvironment; Up-Regulation | 2017 |
Autophagy plays a protective role against apoptosis induced by toxicarioside N via the Akt/mTOR pathway in human gastric cancer SGC-7901 cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Cytoprotection; Glycosides; Humans; Proto-Oncogene Proteins c-akt; Signal Transduction; Stomach Neoplasms; TOR Serine-Threonine Kinases | 2018 |
The anticancer effects of pharmacological inhibition of autophagy in acute erythroid leukemia cells.
Topics: Adenine; Antimetabolites, Antineoplastic; Autophagy; Cell Line, Tumor; Chloroquine; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cytarabine; Down-Regulation; G1 Phase; Humans; Leukemia, Erythroblastic, Acute; MicroRNAs; Resting Phase, Cell Cycle; Up-Regulation | 2018 |
ROS‑mediated autophagy through the AMPK signaling pathway protects INS‑1 cells from human islet amyloid polypeptide‑induced cytotoxicity.
Topics: Adenine; AMP-Activated Protein Kinases; Autophagy; Cell Line; Humans; Islet Amyloid Polypeptide; Malondialdehyde; Microtubule-Associated Proteins; Oxidative Stress; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction | 2018 |
Active fraction of clove induces apoptosis via PI3K/Akt/mTOR-mediated autophagy in human colorectal cancer HCT-116 cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Macrolides; Phosphatidylinositol 3-Kinases; Plant Extracts; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Syzygium; TOR Serine-Threonine Kinases | 2018 |
An engineered novel lentivector specifically transducing dendritic cells and eliciting robust HBV-specific CTL response by upregulating autophagy in T cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; CD8-Positive T-Lymphocytes; Cell Adhesion Molecules; Dendritic Cells; Genetic Engineering; Genetic Vectors; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Lectins, C-Type; Lentivirus; Lymphocyte Activation; Mice, Inbred BALB C; Receptors, Cell Surface; S Phase; T-Lymphocytes, Cytotoxic; Transduction, Genetic; Tumor Necrosis Factor Ligand Superfamily Member 14; Ubiquitin; Up-Regulation | 2018 |
Human non‑small cell lung cancer cells can be sensitized to camptothecin by modulating autophagy.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Camptothecin; Carcinoma, Non-Small-Cell Lung; Caspase Inhibitors; Cell Line, Tumor; Cell Movement; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Histones; Humans; Inhibitory Concentration 50; Lung Neoplasms | 2018 |
Resveratrol inhibited the progression of human hepatocellular carcinoma by inducing autophagy via regulating p53 and the phosphoinositide 3‑kinase/protein kinase B pathway.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Benzothiazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Resveratrol; Signal Transduction; Stilbenes; Toluene; Tumor Suppressor Protein p53; Up-Regulation | 2018 |
Autophagy in Paracoccidioides brasiliensis under normal mycelia to yeast transition and under selective nutrient deprivation.
Topics: Adenine; Autophagy; Gene Expression Regulation, Fungal; Mycelium; Nutrients; Oxidative Stress; Paracoccidioides; Paracoccidioidomycosis; Saccharomyces cerevisiae; Sirolimus | 2018 |
Antioxidant N-acetylcysteine inhibits maladaptive myocyte autophagy in pressure overload induced cardiac remodeling in rats.
Topics: Acetylcysteine; Adaptation, Physiological; Adenine; Animals; Antioxidants; Autophagy; Blood Pressure; Extracellular Signal-Regulated MAP Kinases; Fibrosis; Male; Myocytes, Cardiac; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rats; Rats, Sprague-Dawley; Ventricular Remodeling | 2018 |
β-Arrestin1 enhances liver fibrosis through autophagy-mediated Snail signaling.
Topics: Adenine; Animals; Autophagy; beta-Arrestin 1; Cell Line; Female; Glycogen Synthase Kinase 3 beta; Hepatic Stellate Cells; Hepatocytes; Humans; Liver Cirrhosis; Male; Mice; Mice, Knockout; Signal Transduction; Snail Family Transcription Factors | 2019 |
Parkin Modulates ERRα/eNOS Signaling Pathway in Endothelial Cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Endothelial Cells; ERRalpha Estrogen-Related Receptor; Macrolides; Membrane Potential, Mitochondrial; Mice; Microtubule-Associated Proteins; Mitochondria; Nitric Oxide Synthase Type III; Nitriles; Reactive Oxygen Species; Receptors, Estrogen; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiazoles; Ubiquitin-Protein Ligases; Ubiquitination | 2018 |
Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.
Topics: Adenine; Adipocytes; Adipose Tissue; Autophagy; Calcimimetic Agents; Cell Line; Cinacalcet; Gene Knockdown Techniques; Humans; Inflammation; Obesity; Primary Cell Culture; Receptors, Calcium-Sensing; Tumor Necrosis Factor-alpha | 2018 |
Inhibition of autophagy after perforator flap surgery increases flap survival and angiogenesis.
Topics: Adenine; Animals; Autophagy; Drug Evaluation, Preclinical; Graft Survival; Male; Microvessels; Neovascularization, Physiologic; Perforator Flap; Rats, Sprague-Dawley; Vascular Endothelial Growth Factor A | 2018 |
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chromones; Cobalt; Disease Models, Animal; Erythropoietin; Humans; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Morpholines; Peptide Fragments; Proto-Oncogene Proteins c-akt; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Enhancing Autophagy Protects Against Sepsis-Induced Neuromuscular Dysfunction Associated with Qualitative Changes to Acetylcholine Receptors.
Topics: Adenine; Animals; Autophagy; Cecum; Ligation; Male; Punctures; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Sepsis; Sirolimus; Sphingosine-1-Phosphate Receptors | 2019 |
Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Cell Line; Disease Models, Animal; Extracellular Matrix; Fibrosis; G2 Phase Cell Cycle Checkpoints; Glomerulonephritis; Hyperuricemia; Kidney; Male; Myofibroblasts; Oxidative Stress; Phenotype; Phosphorylation; Rats; Rats, Sprague-Dawley; Wnt Signaling Pathway | 2018 |
The involvement of autophagic flux in the development and recovery of doxorubicin-induced neurotoxicity.
Topics: Adenine; Animals; Autophagy; Beclin-1; Cathepsin D; Doxorubicin; Endoplasmic Reticulum Stress; Gene Expression Regulation; Heart; Hippocampus; Injections, Intraperitoneal; Lysosomal-Associated Membrane Protein 2; Lysosomes; Male; Microtubule-Associated Proteins; Neurons; Neurotoxicity Syndromes; Oxidative Stress; Rats; Rats, Sprague-Dawley; Sequestosome-1 Protein; Signal Transduction | 2018 |
Knockdown of insulin-like growth factor 1 exerts a protective effect on hypoxic injury of aged BM-MSCs: role of autophagy.
Topics: Adenine; Age Factors; Animals; Apoptosis; Autophagy; Bone Marrow Cells; Cell Hypoxia; Cellular Senescence; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Myocardial Infarction; Oxygen; Primary Cell Culture; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
ROS Promote Ox-LDL-Induced Platelet Activation by Up-Regulating Autophagy Through the Inhibition of the PI3K/AKT/mTOR Pathway.
Topics: Acetylcysteine; Adenine; Autophagy; Beclin-1; Blood Platelets; Cell Adhesion; Humans; Lipoproteins, LDL; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Platelet Activation; Platelet Aggregation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA-Binding Proteins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Anti-hypoxic effect of dihydroartemisinin on pulmonary artery endothelial cells.
Topics: Adenine; Artemisinins; Autophagosomes; Autophagy; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Proliferation; Endothelial Cells; Humans; Neovascularization, Physiologic; Oxidative Stress; Pulmonary Artery | 2018 |
CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.
Topics: Adenine; Animals; Autophagy; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chromones; Cranial Nerves; Disease Models, Animal; Facial Nerve; Facial Nerve Injuries; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Male; Microtubule-Associated Proteins; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Isoforms; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Schwann Cells; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Coronary Vessels; Early Growth Response Protein 1; Gene Expression Regulation; Male; Myocardial Infarction; Random Allocation; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA Interference | 2018 |
MiR-138-5p affects insulin resistance to regulate type 2 diabetes progression through inducing autophagy in HepG2 cells by regulating SIRT1.
Topics: Adenine; Autophagy; Diabetes Mellitus, Type 2; Disease Progression; Down-Regulation; Glucose; Glycogen; Hep G2 Cells; Humans; Insulin; Insulin Resistance; MicroRNAs; Sirtuin 1; Tumor Necrosis Factor-alpha | 2018 |
Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells.
Topics: Adenine; AMP-Activated Protein Kinase Kinases; Animals; Autophagy; Cell Proliferation; Hot Temperature; Human Umbilical Vein Endothelial Cells; Humans; Macrolides; Neovascularization, Physiologic; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
Ganoderma tsugae induced ROS-independent apoptosis and cytoprotective autophagy in human chronic myeloid leukemia cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chloroquine; Drugs, Chinese Herbal; G2 Phase Cell Cycle Checkpoints; Ganoderma; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins; Signal Transduction | 2019 |
Increased Autophagy Enhances the Resistance to Tumor Necrosis Factor-Alpha Treatment in Rheumatoid Arthritis Human Fibroblast-Like Synovial Cell.
Topics: Adenine; Apoptosis; Arthritis, Rheumatoid; Autophagosomes; Autophagy; Fibroblasts; Humans; Microtubule-Associated Proteins; Synoviocytes; Tumor Necrosis Factor-alpha | 2018 |
Autophagy facilitates anticancer effect of 5-fluorouracil in HCT-116 cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Beclin-1; Cell Proliferation; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Drug Synergism; Fluorouracil; HCT116 Cells; Humans; Microtubule-Associated Proteins; RNA, Small Interfering; Sirolimus | 2018 |
Inhibition of autophagy enhances cinobufagin‑induced apoptosis in gastric cancer.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Bufanolides; Cell Line, Tumor; Drug Synergism; Humans; Membrane Potential, Mitochondrial; Reactive Oxygen Species; RNA, Small Interfering; Stomach Neoplasms | 2019 |
Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway.
Topics: Acetylcysteine; Adenine; Animals; Antineoplastic Agents; Autophagy; Autophagy-Related Protein 5; Chloroquine; Cisplatin; Gene Expression Regulation; Genes, Reporter; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Luminescent Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microtubule-Associated Proteins; Proto-Oncogene Proteins c-akt; Red Fluorescent Protein; RNA, Small Interfering; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases; Virus Activation; Virus Replication | 2019 |
Deficiency of apoptosis-stimulating protein two of p53 promotes liver regeneration in mice by activating mammalian target of rapamycin.
Topics: Adenine; Animals; Autophagy; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation; Haploinsufficiency; Hepatocytes; Liver Regeneration; Mechanistic Target of Rapamycin Complex 1; Mice; Sirolimus; Tumor Suppressor Proteins | 2018 |
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux.
Topics: Adenine; Animals; Antioxidants; Apoptosis; Autophagy; Autophagy-Related Protein 5; Benzofurans; Cell Line, Tumor; Chloroquine; Flavonoids; Hepatocytes; Humans; Mice; Mitophagy; Molecular Structure; Reactive Oxygen Species; Structure-Activity Relationship | 2019 |
Combination of 3-methyladenine therapy and Asn-Gly-Arg (NGR)-modified mesoporous silica nanoparticles loaded with temozolomide for glioma therapy in vitro.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Drug Carriers; Drug Delivery Systems; Glioma; Nanoparticles; Oligopeptides; Rats; Silicon Dioxide; Temozolomide | 2019 |
Autophagy is involved in the differentiation of epicardial progenitor cells into vascular smooth muscle cells in mice.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cells, Cultured; Coronary Vessels; Female; Male; Mice; Mice, Inbred C57BL; Mouse Embryonic Stem Cells; Myocytes, Smooth Muscle; Pericardium | 2019 |
The aggravating effect of selenium deficiency on T-2 toxin-induced damage on primary cardiomyocyte results from a reduction of protective autophagy.
Topics: Adenine; Animals; Autophagy; Beclin-1; Caspase 3; Cell Survival; Microtubule-Associated Proteins; Myocytes, Cardiac; Rats; Rats, Wistar; Selenium; Sirolimus; T-2 Toxin | 2019 |
Identifying key barriers in cationic polymer gene delivery to human T cells.
Topics: Adenine; Autophagy; Carbocyanines; Cations; Cell Survival; HeLa Cells; Humans; Hydrogen-Ion Concentration; Jurkat Cells; Microscopy, Confocal; Plasmids; Polymers; Sirolimus; T-Lymphocytes; Transfection | 2019 |
Quercetin alleviates high glucose-induced damage on human umbilical vein endothelial cells by promoting autophagy.
Topics: Adenine; Antioxidants; Autophagy; Beclin-1; Cell Movement; Cell Survival; Cytoprotection; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Microtubule-Associated Proteins; Oxidative Stress; Quercetin; Reactive Oxygen Species; RNA-Binding Proteins | 2019 |
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
Topics: Adenine; Animals; Atherosclerosis; Autophagosomes; Autophagy; Autophagy-Related Protein 7; Chromatin Immunoprecipitation Sequencing; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipoproteins, LDL; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Mixed Function Oxygenases; Protein Kinases; RNA, Long Noncoding; Signal Transduction; Tissue Array Analysis; TOR Serine-Threonine Kinases | 2019 |
Two mechanisms involving the autophagic and proteasomal pathways process the metastasis suppressor protein, N-myc downstream regulated gene 1.
Topics: Adenine; Antineoplastic Agents; Autophagy; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Epithelial Cells; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; Immediate-Early Proteins; Intracellular Signaling Peptides and Proteins; Iron Chelating Agents; Leupeptins; Macrolides; Microtubule-Associated Proteins; Pancreatic Ducts; Phosphorylation; Proteasome Endopeptidase Complex; Protein Isoforms; Protein Serine-Threonine Kinases; Proteolysis; Signal Transduction; Thiosemicarbazones | 2019 |
Reduced levels of modified nucleosides in the urine of autistic children. Preliminary studies.
Topics: Adenine; Adenosine; Adolescent; Autistic Disorder; Child; Child, Preschool; Chromatography, Liquid; Female; Guanine; Guanosine; Humans; Male; Mass Spectrometry | 2019 |
Inhibition of autophagy by 3-MA promotes hypoxia-induced apoptosis in human colorectal cancer cells.
Topics: Adenine; Annexin A5; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Humans; Hypoxia; Membrane Potential, Mitochondrial; Microtubule-Associated Proteins | 2019 |
Autophagy Induced by Oxygen-Glucose Deprivation Mediates the Injury to the Neurovascular Unit.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Hypoxia; Cell Line; Cell Survival; Cells, Cultured; Cerebral Cortex; Endothelial Cells; Glucose; Humans; Hypoxia-Ischemia, Brain; Myocytes, Smooth Muscle; Neurons; Neurovascular Coupling; Oxygen; Rats | 2019 |
Autophagy inhibition plays a protective role against 3, 4-methylenedioxymethamphetamine (MDMA)-induced loss of serotonin transporters and depressive-like behaviors in rats.
Topics: Adenine; Animals; Autophagy; Behavior, Animal; Brain; Depression; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Rats, Sprague-Dawley; Serotonergic Neurons; Serotonin Plasma Membrane Transport Proteins | 2019 |
Inhibition of Autophagy Improves the Efficacy of Abiraterone for the Treatment of Prostate Cancer.
Topics: Adenine; Androstenes; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Male; Prostatic Neoplasms, Castration-Resistant | 2019 |
Aged kidneys are refractory to autophagy activation in a rat model of renal ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Adenine; Age Factors; Animals; Apoptosis; Autophagosomes; Autophagy; Beclin-1; Blood Urea Nitrogen; Caspase 3; Creatinine; Disease Models, Animal; Kidney; Male; Microtubule-Associated Proteins; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2019 |
Inhibition of mitochondrial autophagy protects donor lungs for lung transplantation against ischaemia-reperfusion injury in rats via the mTOR pathway.
Topics: Adenine; Animals; Autophagy; Endothelial Cells; Humans; Lung; Lung Transplantation; Mitochondria; Rats; Reperfusion Injury; Signal Transduction; Sirolimus; Tissue Donors; TOR Serine-Threonine Kinases | 2019 |
Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway.
Topics: Adenine; Amyloid beta-Peptides; Animals; Autophagy; Bone Marrow Cells; Cell Cycle Checkpoints; Cell Proliferation; Mesenchymal Stem Cells; Microtubule-Associated Proteins; Peptide Fragments; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Autophagy induced by enterovirus 71 regulates the production of IL-6 through the p38MAPK and ERK signaling pathways.
Topics: Adenine; Autophagy; Cell Line; Cell Proliferation; Chloroquine; Enterovirus A, Human; Enterovirus Infections; Gene Expression Regulation; Humans; Interleukin-6; MAP Kinase Signaling System; p38 Mitogen-Activated Protein Kinases; Phosphorylation | 2019 |
CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans.
Topics: Adenine; Amino Acid Sequence; Animals; Animals, Genetically Modified; Autophagy; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Membrane Permeability; Green Fluorescent Proteins; Luminescent Proteins; Microscopy, Confocal; Recombinant Fusion Proteins; Sequence Alignment | 2019 |
Inhibition of miR-155 reduces impaired autophagy and improves prognosis in an experimental pancreatitis mouse model.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagosomes; Autophagy; Ceruletide; Disease Models, Animal; Inflammation; Lung; Male; Mice; MicroRNAs; Pancreas; Pancreatitis; Prognosis | 2019 |
The role of orthosilicic acid-induced autophagy on promoting differentiation and mineralization of osteoblastic cells.
Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Tumor-Associated, Carbohydrate; Autophagy; Bone Density; Calcification, Physiologic; Cell Differentiation; Cell Line; Collagen; Core Binding Factor Alpha 2 Subunit; Female; Glycoproteins; Humans; Mice; Microtubule-Associated Proteins; Models, Animal; Osteoblasts; Osteogenesis; Rats, Wistar; RNA-Binding Proteins; Sequestosome-1 Protein; Silicic Acid | 2019 |
The effect of autophagy on the survival and invasive activity of Eimeria tenella sporozoites.
Topics: Adenine; Adenosine Triphosphate; Autophagosomes; Autophagy; Eimeria tenella; Sirolimus; Sporozoites | 2019 |
Microwave hyperthermia enhances the sensitivity of lung cancer cells to gemcitabine through reactive oxygen species‑induced autophagic death.
Topics: Adenine; Autophagy; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Humans; Hyperthermia, Induced; Lung Neoplasms; Microwaves; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Haemophilus parasuis infection in 3D4/21 cells induces autophagy through the AMPK pathway.
Topics: Adenine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Haemophilus parasuis; Host-Pathogen Interactions; Luminescent Proteins; Macrophages, Alveolar; Microtubule-Associated Proteins; Oxazines; Protein Isoforms; Red Fluorescent Protein; Ribonucleotides; Signal Transduction; Sirolimus; Swine; Virulence | 2019 |
TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Brain; Brain Ischemia; Cells, Cultured; Cerebral Arteries; Disease Models, Animal; Humans; Mice; Mice, Knockout; Mice, Transgenic; Neurons; Neuroprotective Agents; Phosphoric Monoester Hydrolases; Reperfusion Injury; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Chaperone-mediated autophagy degradation of IGF-1Rβ induced by NVP-AUY922 in pancreatic cancer.
Topics: Adenine; Amino Acid Sequence; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lysosomal-Associated Membrane Protein 2; Lysosomes; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Resorcinols; RNA Interference; RNA, Small Interfering; Sequence Alignment; Signal Transduction | 2019 |
The Dual Role of HIV-1 gp120 V3 Loop-Induced Autophagy in the Survival and Apoptosis of the Primary Rat Hippocampal Neurons.
Topics: Adenine; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hippocampus; HIV Envelope Protein gp120; HIV-1; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Kinase Inhibitors; Rats, Sprague-Dawley | 2019 |
Protective effect of ulinastatin on hepatic ischemia reperfusion injury through autophagy activation in Chang liver cells.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Caspase 3; Cell Line; Cell Proliferation; Glycoproteins; Hepatocytes; Humans; Intracellular Signaling Peptides and Proteins; Liver; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Poly (ADP-Ribose) Polymerase-1; Reperfusion Injury; RNA-Binding Proteins; Trypsin Inhibitors | 2019 |
MiR-135-5p-p62 Axis Regulates Autophagic Flux, Tumorigenic Potential, and Cellular Interactions Mediated by Extracellular Vesicles During Allergic Inflammation.
Topics: Adenine; Animals; Autophagy; Carcinogenesis; Cell Communication; Cell Line; Disease Models, Animal; Extracellular Vesicles; Female; Humans; Hypersensitivity; Immunomodulation; Inflammation; Mice; Mice, Inbred BALB C; MicroRNAs; Passive Cutaneous Anaphylaxis; Rats; Sequestosome-1 Protein | 2019 |
Protective effect of Tenuifolin against Alzheimer's disease.
Topics: Adenine; Alzheimer Disease; AMP-Activated Protein Kinases; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Apoptosis; Aspartic Acid Endopeptidases; Autophagy; Autophagy-Related Protein-1 Homolog; Beclin-1; Cell Line, Tumor; Cell Survival; Diterpenes, Kaurane; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Microtubule-Associated Proteins; Neuroprotective Agents; Peptide Fragments; TOR Serine-Threonine Kinases | 2019 |
ROS Generated by Upconversion Nanoparticle-Mediated Photodynamic Therapy Induces Autophagy via PI3K/AKT/ mTOR Signaling Pathway in M1 Peritoneal Macrophage.
Topics: Adenine; Animals; Autophagy; Beclin-1; Interleukin-12; Lipopolysaccharides; Macrophages, Peritoneal; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Photochemotherapy; Porphyrins; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2019 |
Recombinant human arginase I elicited immunosuppression in activated macrophages through inhibiting autophagy.
Topics: Adenine; Animals; Arginase; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cytokines; Histocompatibility Antigens Class II; Humans; Immunosuppressive Agents; Liver Neoplasms; Macrophages; Mice; Nitric Oxide; Phagocytosis; RAW 264.7 Cells; Reactive Oxygen Species; Recombinant Proteins; Trehalose | 2019 |
Role of autophagy in LPS‑induced inflammation in INS‑1 cells.
Topics: Acetylcysteine; Adenine; Animals; Apoptosis; Autophagy; Caspase 1; Cell Line; Inflammasomes; Inflammation; Interleukin-1beta; Lipopolysaccharides; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Reactive Oxygen Species | 2019 |
Interleukin‑17A facilitates osteoclast differentiation and bone resorption via activation of autophagy in mouse bone marrow macrophages.
Topics: Actins; Adenine; Alveolar Bone Loss; Animals; Autophagosomes; Autophagy; Bone Marrow; Bone Resorption; Cell Differentiation; Cell Survival; Disease Models, Animal; Female; Gene Expression Regulation; Immunohistochemistry; Interleukin-17; Macrophages; Male; Mice; Mice, Inbred C57BL; Osteoclasts; Osteogenesis; Periodontitis; Rats; Rats, Sprague-Dawley | 2019 |
3-Methyladenine alleviates excessive iodine-induced cognitive impairment via suppression of autophagy in rat hippocampus.
Topics: Adenine; Animals; Autophagy; Cognitive Dysfunction; Female; Hippocampus; Iodine; Male; Malondialdehyde; Maze Learning; Rats | 2019 |
p62/mTOR/LXRα pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage.
Topics: Adenine; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; Autophagy; Cholesterol; Humans; Liver X Receptors; RNA, Small Interfering; Signal Transduction; THP-1 Cells; TOR Serine-Threonine Kinases; Transcription Factor TFIIH | 2019 |
Follistatin-Like 1 Attenuates Ischemia/Reperfusion Injury in Cardiomyocytes via Regulation of Autophagy.
Topics: Adenine; Apoptosis; Autophagy; Cell Line; Cell Proliferation; Cell Survival; Follistatin-Related Proteins; Models, Biological; Myocardial Reperfusion Injury; Myocytes, Cardiac; Sirolimus | 2019 |
Combining use of Phillyrin and autophagy blocker alleviates laryngeal squamous cell carcinoma via AMPK/mTOR/p70S6K signaling.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Chloroquine; Glucosides; Humans; Laryngeal Neoplasms; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells.
Topics: Adenine; Aging; Animals; Antigens, Neoplasm; Autophagy; Cellular Senescence; Gene Expression Regulation; Glycation End Products, Advanced; Humans; Kidney; Mesangial Cells; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Rats; Renal Insufficiency, Chronic; Signal Transduction; STAT5 Transcription Factor | 2019 |
Autophagy induces eosinophil extracellular traps formation and allergic airway inflammation in a murine asthma model.
Topics: Adenine; Animals; Anti-Asthmatic Agents; Asthma; Autophagy; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Energy Metabolism; Eosinophil Peroxidase; Eosinophils; Extracellular Traps; Female; Goblet Cells; Lung; Mice; Mice, Inbred BALB C; Mitochondria; Ovalbumin; Oxidative Stress; Reactive Oxygen Species; Transcription Factor RelA | 2020 |
Hypothermic oxygenated machine perfusion alleviates liver injury in donation after circulatory death through activating autophagy in mice.
Topics: Adenine; Animals; Autophagy; Cold Temperature; Liver; Male; Mice; Mice, Inbred C57BL; Organ Preservation; Oxygen; Perfusion; Protective Agents; Warm Ischemia | 2019 |
Intracellular Trafficking Network and Autophagy of PHBHHx Nanoparticles and their Implications for Drug Delivery.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Autophagy; Caveolins; Clathrin; Drug Carriers; Endocytosis; Endosomes; Exocytosis; Humans; MCF-7 Cells; Mice; Mice, SCID; Microscopy, Confocal; Nanoparticles; Neoplasms; Paclitaxel; Polyhydroxyalkanoates; Transplantation, Heterologous | 2019 |
Inhibition of Autophagy Attenuated Intestinal Injury After Intestinal I/R via mTOR Signaling.
Topics: Adenine; Animals; Autophagy; Drug Evaluation, Preclinical; Intestinal Diseases; Intestinal Mucosa; Male; Malondialdehyde; Random Allocation; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus; Superoxide Dismutase; TOR Serine-Threonine Kinases | 2019 |
Autophagy contributes to the feeding, reproduction, and mobility of Bursaphelenchus xylophilus at low temperatures.
Topics: Adenine; Animals; Antibodies; Autophagy; China; Cold Temperature; Forests; Homeostasis; Movement; Nematoda; Pinus; Rabbits; Wood | 2019 |
Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Caseins; Cathepsin D; Cell Death; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Lysosomes; MCF-7 Cells; Mice; Microtubule-Associated Proteins; Morpholines; Neoplasms; Pyrones; Reactive Oxygen Species; Sequestosome-1 Protein | 2019 |
Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; Homocysteine; Male; MAP Kinase Signaling System; Neural Stem Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction; Stroke; TOR Serine-Threonine Kinases | 2019 |
Reciprocal Regulation of Chaperone-Mediated Autophagy/Microautophagy and Exosome Release.
Topics: Adenine; Ammonium Chloride; Cell Line; Chaperone-Mediated Autophagy; Exosomes; Humans; Lysosomal-Associated Membrane Protein 2; Macrolides; Microautophagy; Mycophenolic Acid; RNA, Small Interfering; Sirolimus | 2019 |
MTOR involved in bacterial elimination against Trueperella pyogenes infection based on mice model by transcriptome and biochemical analysis.
Topics: Actinomycetaceae; Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Cytokines; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Silencing; Gram-Positive Bacterial Infections; High-Throughput Nucleotide Sequencing; Liver; Macrophages; Mice; TOR Serine-Threonine Kinases | 2019 |
Neuroprotection by nicotinamide mononucleotide adenylyltransferase 1 with involvement of autophagy in an aged rat model of transient cerebral ischemia and reperfusion.
Topics: Adenine; Animals; Autophagy; Brain Ischemia; Glucose; Infarction, Middle Cerebral Artery; Ischemic Attack, Transient; Male; Neurons; Neuroprotection; Neuroprotective Agents; Nicotinamide-Nucleotide Adenylyltransferase; Oxygen; Rats; Reperfusion; Reperfusion Injury; Signal Transduction; Sirtuin 1; Stroke; TOR Serine-Threonine Kinases | 2019 |
Photodynamic therapy enhances skin cancer chemotherapy effects through autophagy regulation.
Topics: Adenine; Aminolevulinic Acid; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Fluorouracil; Humans; Melanoma; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms | 2019 |
Insulin-Like Growth Factor Binding Protein-Related Protein 1 Activates Primary Hepatic Stellate Cells via Autophagy Regulated by the PI3K/Akt/mTOR Signaling Pathway.
Topics: Actins; Adenine; Animals; Autophagy; Beclin-1; Hepatic Stellate Cells; Insulin-Like Growth Factor Binding Proteins; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinase; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sirolimus; TOR Serine-Threonine Kinases; Transfection; Transforming Growth Factor beta1 | 2020 |
Interplay between oxidative stress and autophagy function and its role in inflammatory cytokine expression induced by palmitate in skeletal muscle cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chloroquine; Cytokines; Free Radical Scavengers; Inflammation; Interleukin-6; Mice; Microtubule-Associated Proteins; Muscle, Skeletal; Oxidative Stress; Palmitates; Reactive Oxygen Species; Sequestosome-1 Protein; Sirolimus; Tumor Necrosis Factor-alpha | 2020 |
Induction of Autophagic Death of Human Hepatocellular Carcinoma Cells by Armillaridin from
Topics: Adenine; Antineoplastic Agents, Phytogenic; Armillaria; Autophagic Cell Death; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Mitochondrial Transmembrane Permeability-Driven Necrosis; Sesquiterpenes | 2019 |
RE-1 silencing transcription factor alleviates the growth-suppressive effects of propofol on mouse neuronal cells.
Topics: Adenine; Anesthetics, Intravenous; Animals; Apoptosis; Autophagy; Brain-Derived Neurotrophic Factor; Cell Line; Cell Proliferation; Mice; Mice, Knockout; Neurons; Propofol; Repressor Proteins; RNA, Messenger; RNA, Small Interfering | 2019 |
Effects of autophagy on apoptosis of articular chondrocytes in adjuvant arthritis rats.
Topics: Adenine; Animals; Apoptosis; Arthritis, Experimental; Autophagy; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease Models, Animal; Male; Rats, Sprague-Dawley; Sirolimus | 2019 |
Biphasic effects of autophagy on decompression bubble-induced endothelial injury.
Topics: Adenine; Apoptosis; Autophagosomes; Autophagy; Beclin-1; Caspase 3; Cell Survival; Cytochromes c; Decompression Sickness; Endothelium; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; RNA-Binding Proteins; Time Factors | 2019 |
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK
Topics: Adenine; Animals; Autophagy; Base Sequence; Carcinogenesis; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Proliferation; Cell Survival; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Lysosomes; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Middle Aged; Models, Biological; Mouth Neoplasms; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; RNA, Circular; TOR Serine-Threonine Kinases; Tumor Burden; Tumor Microenvironment; Up-Regulation | 2019 |
Autophagy Precedes Apoptosis in Angiotensin II-Induced Podocyte Injury.
Topics: Adenine; Angiotensin II; Animals; Apoptosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Beclin-1; Mice; Microtubule-Associated Proteins; Podocytes; RNA Interference; RNA, Small Interfering; Up-Regulation | 2019 |
Autophagy: A Novel Mechanism Involved in the Anti-Inflammatory Abilities of Probiotics.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Bifidobacterium; Bone Marrow Cells; Carrier Proteins; Chemokines; Colitis; Cytokines; Dendritic Cells; Female; Humans; Lactobacillus; Leukocytes, Mononuclear; Macrolides; Mice; Mice, Inbred BALB C; Mice, Knockout | 2019 |
Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps.
Topics: Adenine; DNA; Extracellular Traps; Granulomatous Disease, Chronic; Humans; Leukocyte Elastase; Neutrophils; Nitric Oxide; p38 Mitogen-Activated Protein Kinases; Peroxynitrous Acid; Phosphatidylinositol 3-Kinases; Reactive Nitrogen Species; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2020 |
Dexmedetomidine Protects Against Oxygen-Glucose Deprivation-Induced Injury Through Inducing Astrocytes Autophagy via TSC2/mTOR Pathway.
Topics: Adenine; Animals; Astrocytes; Autophagy; Cell Hypoxia; Cells, Cultured; Dexmedetomidine; Drug Evaluation, Preclinical; Glucose; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuroprotective Agents; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein | 2020 |
The autophagic inducer and inhibitor display different activities on the meiotic and developmental competencies of porcine oocytes derived from small and medium follicles.
Topics: Adenine; Animals; Autophagy; Cell Size; Cells, Cultured; Cumulus Cells; Embryonic Development; Female; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Oogenesis; Ovarian Follicle; Parthenogenesis; Sirolimus; Swine | 2019 |
Chloroquine and 3-Methyladenine Attenuates Periodontal Inflammation and Bone Loss in Experimental Periodontitis.
Topics: Adenine; Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents; Autophagy; Autophagy-Related Proteins; Cells, Cultured; Chloroquine; Disease Models, Animal; Male; Osteoclasts; Osteogenesis; Periodontitis; Porphyromonas gingivalis; Rats, Sprague-Dawley; Transcription Factor RelA | 2020 |
Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation.
Topics: Adenine; Animals; Animals, Newborn; Autophagy; Brain Damage, Chronic; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Ischemia, Brain; Ischemic Preconditioning; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Simvastatin; Sirtuin 1 | 2020 |
Autophagic Survival Precedes Programmed Cell Death in Wheat Seedlings Exposed to Drought Stress.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 8 Family; Beclin-1; Droughts; Plant Leaves; Plant Proteins; Plant Roots; Polyethylene Glycols; RNA Interference; RNA, Double-Stranded; Seedlings; Triticum | 2019 |
Excessive ER-phagy mediated by the autophagy receptor FAM134B results in ER stress, the unfolded protein response, and cell death in HeLa cells.
Topics: Adenine; Apoptosis; Autophagosomes; Autophagy; Autophagy-Related Proteins; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Endoribonucleases; HeLa Cells; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Protein Serine-Threonine Kinases; RNA Interference; RNA, Small Interfering; Unfolded Protein Response; Up-Regulation; Vesicular Transport Proteins | 2019 |
Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Drug Carriers; Female; Ferrosoferric Oxide; Humans; Immunotherapy; Interleukin-1beta; Macrophages; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Polyethylene Glycols; Porosity; Serum Albumin, Bovine; Transcription Factor RelA | 2020 |
Quercetin Suppresses the Progression of Atherosclerosis by Regulating MST1-Mediated Autophagy in ox-LDL-Induced RAW264.7 Macrophage Foam Cells.
Topics: Adenine; Animals; Atherosclerosis; Autophagy; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Disease Progression; Foam Cells; Hepatocyte Growth Factor; Lipid Metabolism; Lipoproteins, LDL; Mice; Proto-Oncogene Proteins; Quercetin; RAW 264.7 Cells; Sirolimus; Up-Regulation | 2019 |
Platinum-based combination chemotherapy triggers cancer cell death through induction of BNIP3 and ROS, but not autophagy.
Topics: A549 Cells; Adenine; Antineoplastic Agents; Autophagy; Cell Death; Drug Therapy, Combination; Humans; Lung Neoplasms; Membrane Proteins; Mitochondria; Mitochondrial Membranes; Models, Biological; Platinum; Protein Transport; Proto-Oncogene Proteins; Reactive Oxygen Species | 2020 |
Protective effects of autophagy inhibitor 3-methyladenine on ischemia-reperfusion-induced retinal injury.
Topics: Adenine; Animals; Apoptosis; Autophagy; Beclin-1; Blotting, Western; Cell Count; Disease Models, Animal; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Ganglion Cells; Retinal Vessels | 2020 |
Impairment of mitochondrial dynamics involved in iron oxide nanoparticle-induced dysfunction of dendritic cells was alleviated by autophagy inhibitor 3-methyladenine.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cells, Cultured; Dendritic Cells; Endocytosis; Magnetic Iron Oxide Nanoparticles; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria; Mitochondrial Dynamics; Phenotype | 2020 |
Melatonin triggers autophagic cell death by regulating RORC in Hodgkin lymphoma.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagic Cell Death; Cell Line, Tumor; Cell Survival; Hodgkin Disease; Humans; Melatonin; Nuclear Receptor Subfamily 1, Group F, Member 3 | 2020 |
Nicotine-induced autophagy via AMPK/mTOR pathway exerts protective effect in colitis mouse model.
Topics: Adenine; Adenylate Kinase; Animals; Autophagy; Colitis; Dextran Sulfate; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Nicotine; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases | 2020 |
Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation.
Topics: Adenine; Autophagy; Cell Differentiation; Cell Line; Cell Nucleus; Humans; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Osteogenesis; Protein Stability; Proteolysis; Receptor, Cannabinoid, CB2; Sequestosome-1 Protein; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Low-dose caffeine administration increases fatty acid utilization and mitochondrial turnover in C2C12 skeletal myotubes.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Caffeine; Cell Line; Central Nervous System Stimulants; Fatty Acids; Flow Cytometry; Lipid Metabolism; Macrolides; Mice; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mitochondrial Dynamics; Mitochondrial Turnover; Mitophagy; Muscle Fibers, Skeletal; Myoblasts; Oleic Acid; Organelle Biogenesis; Oxidation-Reduction; Oxygen Consumption | 2020 |
Cross-talk between autophagy and apoptosis regulates testicular injury/recovery induced by cadmium via PI3K with mTOR-independent pathway.
Topics: Adenine; Aging; Animals; Apoptosis; Autophagy; Cadmium; Cell Line; Male; Models, Biological; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Rats, Sprague-Dawley; Reproduction; Signal Transduction; Testis; TOR Serine-Threonine Kinases | 2020 |
NUPR1 Silencing Induces Autophagy-Mediated Apoptosis in Multiple Myeloma Cells Through the PI3K/AKT/mTOR Pathway.
Topics: Adenine; Apoptosis; Autophagy; Basic Helix-Loop-Helix Transcription Factors; Bone Marrow Cells; Cell Line, Tumor; Chloroquine; Gene Silencing; Humans; Multiple Myeloma; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
3-Methyladenine Inhibits Procollagen-1 and Fibronectin Expression in Dermal Fibroblasts Independent of Autophagy.
Topics: Adenine; Autophagy; Cells, Cultured; Dermis; E1A-Associated p300 Protein; Extracellular Matrix; Fibroblasts; Fibronectins; Humans; Phosphorylation; Procollagen; Smad3 Protein | 2020 |
Intestinal Alkaline Phosphatase Exerts Anti-Inflammatory Effects Against Lipopolysaccharide by Inducing Autophagy.
Topics: Adenine; Alkaline Phosphatase; Animals; Autophagy; Autophagy-Related Protein 5; Cattle; Cell Line, Tumor; Female; HCT116 Cells; Humans; Inflammation; Intestines; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Monocytes; RAW 264.7 Cells; RNA, Small Interfering; Toll-Like Receptor 4 | 2020 |
Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Chloroquine; Intracellular Signaling Peptides and Proteins; Lactoferrin; Mice; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Sirolimus | 2020 |
Taurine induces autophagy and inhibits oxidative stress in mice Leydig cells.
Topics: Adenine; Animals; Antioxidants; Apoptosis; Autophagy; Cell Line; Leydig Cells; Male; Mice; Oxidative Stress; Reactive Oxygen Species; Taurine; Testosterone | 2020 |
Autophagy during left ventricular redilation after ventriculoplasty: Insights from a rat model of ischemic cardiomyopathy.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Proteins; Cardiomyopathy, Dilated; Cardiomyoplasty; Cardiovascular Agents; Echocardiography; Microtubule-Associated Proteins; Myocardial Ischemia; Myocytes, Cardiac; Rats; Recurrence; Ventricular Function, Left; Ventricular Remodeling | 2022 |
Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation.
Topics: Adenine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Beclin-1; Caspase 3; Cell Proliferation; Disease Models, Animal; Ischemia; Kidney; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus | 2020 |
Arctigenin suppresses cell proliferation via autophagy inhibition in hepatocellular carcinoma cells.
Topics: Adenine; Apoptosis; Apoptosis Regulatory Proteins; Arctium; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Forsythia; Furans; Hep G2 Cells; Humans; Lignans; Liver Neoplasms; Sequestosome-1 Protein | 2020 |
Biologically active pigment and ShlA cytolysin of Serratia marcescens induce autophagy in a human ocular surface cell line.
Topics: Adenine; Autophagy; Bacterial Physiological Phenomena; Bacterial Proteins; Cell Line; Epithelium, Corneal; Green Fluorescent Proteins; Hemolysin Proteins; Humans; Keratitis; Limbus Corneae; Microscopy, Confocal; Perforin; Prodigiosin; Serratia marcescens | 2020 |
FGF21 induces autophagy-mediated cholesterol efflux to inhibit atherogenesis via RACK1 up-regulation.
Topics: Adenine; Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cholesterol; Fibroblast Growth Factors; Foam Cells; Lipids; Male; Mice; Mice, Transgenic; Receptors for Activated C Kinase; Up-Regulation | 2020 |
Induction of autophagy promotes porcine parthenogenetic embryo development under low oxygen conditions.
Topics: Adenine; Animals; Antioxidants; Ascorbic Acid; Autophagy; Embryo Culture Techniques; Embryonic Development; Oxidative Stress; Oxygen; Parthenogenesis; Swine | 2020 |
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Topics: ADAM12 Protein; Adenine; Apoptosis; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Cell Proliferation; Choriocarcinoma; Female; Gene Silencing; Humans; Microtubule-Associated Proteins; Pregnancy; RNA, Small Interfering; Uterine Neoplasms | 2020 |
Combination of HSP90 and autophagy inhibitors promotes hepatocellular carcinoma apoptosis following incomplete thermal ablation.
Topics: Adenine; Animals; Apoptosis; Autophagy; Benzoquinones; Carcinoma, Hepatocellular; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Laser Therapy; Liver Neoplasms; Mice, Nude | 2020 |
Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis.
Topics: Adenine; Animals; Aorta; Atherosclerosis; Autophagy; Caveolin 1; Diet, Western; Endothelial Cells; Endothelium, Vascular; Female; Humans; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Mice, Knockout; NIH 3T3 Cells; Receptors, LDL; Vasculitis | 2020 |
Effect of Oleanolic Acid on Apoptosis and Autophagy of SMMC-7721 Hepatoma Cells.
Topics: Adenine; Adenosine Triphosphate; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chloroquine; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Oleanolic Acid | 2020 |
Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy.
Topics: Adenine; Adjuvants, Immunologic; Animals; Autophagy; Beclin-1; CD4-Positive T-Lymphocytes; Cell Line; Cell Proliferation; Enzyme Activation; Glycolipids; Immunogenicity, Vaccine; Immunoglobulin G; Interferon-gamma; Interleukin-2; Macrophages; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Monocytes; NF-E2-Related Factor 2; RAW 264.7 Cells; Serine; Toll-Like Receptor 4; Vaccines | 2020 |
Apalutamide in combination with autophagy inhibitors improves treatment effects in prostate cancer cells.
Topics: Adenine; Autophagy; Chloroquine; Drug Combinations; Drug Screening Assays, Antitumor; Humans; Male; Prostatic Neoplasms; Thiohydantoins; Treatment Outcome; Tumor Cells, Cultured | 2020 |
β-arrestin1 inhibits hypoxic injury-induced autophagy in human pulmonary artery endothelial cells via the Akt/mTOR signaling pathway.
Topics: Adenine; Apoptosis; Autophagosomes; Autophagy; beta-Arrestin 1; Cell Hypoxia; Cell Movement; Cell Proliferation; Endothelial Cells; Gene Knockdown Techniques; Humans; Membrane Proteins; Microscopy, Electron, Transmission; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pulmonary Artery; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Suppressor Proteins | 2020 |
The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy.
Topics: Adenine; Animals; Autophagy; Case-Control Studies; Cell Line, Tumor; China; Disease Models, Animal; Down-Regulation; Female; Gene Expression Profiling; Humans; Indoles; Male; Maleimides; Maternal Age; Mice; Oligonucleotide Array Sequence Analysis; Pre-Eclampsia; Pregnancy; Protein Kinase C beta | 2020 |
Impairment of Autophagy Causes Superoxide Formation and Caspase Activation in 661 W Cells, a Cell Line for Cone Photoreceptors, under Hyperglycemic Conditions.
Topics: Adenine; Animals; Autophagy; Cell Line; Cell Survival; Diabetic Retinopathy; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucose; Mice; Microtubule-Associated Proteins; Models, Biological; Oxidative Stress; Retinal Cone Photoreceptor Cells; Sequestosome-1 Protein; Sirolimus; Superoxides | 2020 |
The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes.
Topics: Adenine; Animals; Apoptosis; Autophagosomes; Autophagy; Cell Proliferation; Cell Survival; Chondrocytes; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Male; Rats, Sprague-Dawley; RNA, Small Interfering; Tunicamycin; Unfolded Protein Response | 2020 |
Diosmetin alleviates hypoxia‑induced myocardial apoptosis by inducing autophagy through AMPK activation.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cardiovascular Agents; Cell Hypoxia; Cell Line; Cytoprotection; Flavonoids; Mice; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Pyrazoles; Pyrimidines | 2020 |
Circ-SPECC1 modulates TGFβ2 and autophagy under oxidative stress by sponging miR-33a to promote hepatocellular carcinoma tumorigenesis.
Topics: Adenine; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cytoskeletal Proteins; Down-Regulation; Humans; Hydrogen Peroxide; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Oxidative Stress; Transforming Growth Factor beta2 | 2020 |
Subcellular Localization of PI3P in Arabidopsis.
Topics: Adenine; Arabidopsis; Arabidopsis Proteins; Endosomes; Phosphatidylinositol Phosphates; Protein Transport; Vesicular Transport Proteins; Wortmannin | 2020 |
Puerarin 6″-O-xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR.
Topics: AC133 Antigen; Adenine; Animals; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Disease Progression; Glycosides; Hep G2 Cells; Humans; Isoflavones; Liver Neoplasms; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay | 2020 |
Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cell Line; Coumaric Acids; Cycloheximide; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Oxidative Stress; Rats; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2020 |
Suppressing endoplasmic reticulum stress-related autophagy attenuates retinal light injury.
Topics: Acetylcysteine; Adenine; Animals; Antioxidants; Autophagy; Cell Line; eIF-2 Kinase; Endoplasmic Reticulum Stress; Humans; Indoles; Light; Male; Mice, Inbred C57BL; Neuroprotective Agents; Oxidative Stress; Photoreceptor Cells, Vertebrate; Retinal Pigment Epithelium | 2020 |
Galangin Improved Non-Alcoholic Fatty Liver Disease in Mice by Promoting Autophagy.
Topics: Adenine; Administration, Oral; Alpinia; Animals; Autophagy; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonoids; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Pharmacological and nutritional modulation of autophagy in a rainbow trout (Oncorhynchus mykiss) gill cell line, RTgill-W1.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Cell Survival; Chloroquine; Fish Proteins; Gene Expression Regulation; Gills; Microtubule-Associated Proteins; Nutrients; Oncorhynchus mykiss; Pharmaceutical Preparations; Serum; Sirolimus; Time Factors; Trichothecenes | 2020 |
Autophagy inhibition protects from alveolar barrier dysfunction in LPS-induced ALI mice by targeting alveolar epithelial cells.
Topics: Acute Lung Injury; Adenine; Alveolar Epithelial Cells; Animals; Autophagy; Bronchoalveolar Lavage Fluid; Chloroquine; Disease Models, Animal; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred C57BL | 2021 |
Pimozide Suppresses the Growth of Brain Tumors by Targeting STAT3-Mediated Autophagy.
Topics: Adenine; Animals; Antineoplastic Agents; Antipsychotic Agents; Autophagy; Autophagy-Related Protein 5; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Repositioning; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Microtubule-Associated Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Pimozide; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2020 |
MKP-5 Relieves Lipotoxicity-Induced Islet β-Cell Dysfunction and Apoptosis via Regulation of Autophagy.
Topics: Adenine; Adenoviridae; Animals; Apoptosis; Autophagy; Diet, High-Fat; Dual-Specificity Phosphatases; Gene Expression Regulation; Genetic Vectors; Islets of Langerhans; JNK Mitogen-Activated Protein Kinases; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Obesity; p38 Mitogen-Activated Protein Kinases; Palmitic Acid; Primary Cell Culture; Protein Kinase Inhibitors; Signal Transduction; Transduction, Genetic | 2020 |
N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation.
Topics: Adenine; Animals; Arachidonic Acids; Autophagy; Cell Survival; Endocannabinoids; Hydrogen Peroxide; Indoles; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tyrosine | 2020 |
Nicotine induces apoptosis through exacerbation of blocked alveolar macrophage autophagic degradation in silicosis.
Topics: Adenine; Apoptosis; Autophagy; Caspase 3; Cells, Cultured; Humans; In Situ Nick-End Labeling; Lysosomes; Macrophages, Alveolar; Male; Microtubule-Associated Proteins; Nicotine; Silicon Dioxide; Silicosis | 2020 |
Role of autophagy in nerve cell apoptosis in mice infected with street rabies virus.
Topics: Adenine; Animals; Apoptosis; Autophagy; Brain; Disease Models, Animal; Fluorescent Antibody Technique, Direct; Mice; Neurons; Rabies; Rabies virus; Sirolimus; Viral Proteins; Virus Replication | 2020 |
Exenatide improves random-pattern skin flap survival via TFE3 mediated autophagy augment.
Topics: Adenine; Adenylate Kinase; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Nucleus; Down-Regulation; Edema; Exenatide; Graft Survival; Male; Mice, Inbred C57BL; Neovascularization, Physiologic; Oxidative Stress; Protein Transport; Protein-Arginine N-Methyltransferases; Pyroptosis; Signal Transduction; Skin; Skin Transplantation; TOR Serine-Threonine Kinases; Up-Regulation | 2021 |
St. John's Wort Suppresses Growth in Triple-Negative Breast Cancer Cell Line MDA-MB-231 by Inducing Prodeath Autophagy and Apoptosis.
Topics: Adenine; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Dose-Response Relationship, Drug; Hypericum; Mice, Nude; Neoplasm Transplantation; Phytotherapy; Plant Extracts; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
TLR9 deficiency alleviates doxorubicin-induced cardiotoxicity via the regulation of autophagy.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cardiomyopathies; Doxorubicin; Inflammation; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Oxidative Stress; Random Allocation; Reactive Oxygen Species; Specific Pathogen-Free Organisms; Toll-Like Receptor 9 | 2020 |
Saponins Extracted from Tea (
Topics: Adenine; Antineoplastic Agents; Apoptosis; Autophagy; Camellia sinensis; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Female; Flowers; Humans; Lysosomes; Microtubule-Associated Proteins; Ovarian Neoplasms; Plant Extracts; Reactive Oxygen Species; Saponins; Signal Transduction | 2020 |
The Role of Autophagy-Mediated Dengue Virus Antibody-Dependent Enhancement Infection of THP-1 Cells.
Topics: Adenine; Antibodies, Viral; Antibody-Dependent Enhancement; Autophagosomes; Autophagy; Autophagy-Related Protein 12; Autophagy-Related Proteins; Dengue; Dengue Virus; Humans; Sirolimus; THP-1 Cells; Transcriptome | 2020 |
Autophagy alleviates mitochondrial DAMP-induced acute lung injury by inhibiting NLRP3 inflammasome.
Topics: Acute Lung Injury; Adenine; Alarmins; Animals; Autophagy; Cytokines; Disease Models, Animal; Inflammasomes; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NLR Family, Pyrin Domain-Containing 3 Protein; Pneumonia; Sirolimus | 2021 |
Effects of prolonged cold-ischemia on autophagy in the graft lung in a rat orthotopic lung transplantation model.
Topics: Adenine; Animals; Autophagy; Cold Ischemia; Glycolysis; Lung; Lung Transplantation; Lysosomal Membrane Proteins; Male; Mitochondria; Oligomycins; Organ Preservation; Oxidative Phosphorylation; Perfusion; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; TOR Serine-Threonine Kinases | 2021 |
Heat shock increases levels of reactive oxygen species, autophagy and apoptosis.
Topics: Adenine; Apoptosis; Autophagy; Autophagy-Related Proteins; Cell Line, Tumor; Combined Modality Therapy; Female; Gene Expression Regulation, Neoplastic; Heat-Shock Response; HeLa Cells; Humans; Hyperthermia, Induced; Macrolides; Reactive Oxygen Species; Thermotolerance; Time Factors; Uterine Cervical Neoplasms | 2021 |
Arsenic-induced autophagy regulates apoptosis in AML-12 cells.
Topics: Adenine; Animals; Apoptosis; Apoptosis Regulatory Proteins; Arsenic Trioxide; Autophagy; Cell Line; Cell Survival; Mice; Microtubule-Associated Proteins; Sirolimus | 2021 |
Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy.
Topics: Adenine; Animals; Autophagy; Cell Differentiation; Disease Models, Animal; Male; Mice; NF-kappa B; Osteoclasts; Periodontitis; Periodontium; RANK Ligand; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction; Syndecan-4; Transcription, Genetic | 2021 |
3-Methyladenine-enhanced susceptibility to sorafenib in hepatocellular carcinoma cells by inhibiting autophagy.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Carcinoma, Hepatocellular; Drug Synergism; Hep G2 Cells; Humans; Liver Neoplasms; Protein Kinase Inhibitors; Sorafenib | 2021 |
Inhibition of autophagy by 3-methyladenine restricts murine cytomegalovirus replication.
Topics: Adenine; Animals; Antigens, Viral; Apoptosis; Autophagy; Caspase 3; Chloroquine; Herpesviridae Infections; Mice; Mice, Inbred C57BL; Muromegalovirus; Virus Replication | 2021 |
Rapamycin and 3-Methyladenine Influence the Apoptosis, Senescence, and Adipogenesis of Human Adipose-Derived Stem Cells by Promoting and Inhibiting Autophagy: An In Vitro and In Vivo Study.
Topics: Adenine; Adipogenesis; Adipose Tissue; Apoptosis; Autophagy; Humans; Sirolimus; Stem Cells | 2021 |
The Effect and Mechanism of Asymmetric Dimethylarginine Regulating Trophoblastic Autophagy on Fetal Growth Restriction.
Topics: Adenine; Adult; Arginine; Autophagy; Beclin-1; Cell Line, Tumor; Female; Fetal Growth Retardation; Humans; Matrix Metalloproteinase 9; Microtubule-Associated Proteins; Placenta; Pregnancy; Trophoblasts | 2021 |
Systematic identification of autophagy-related proteins in Aedes albopictus.
Topics: Adenine; Aedes; Animals; Arbovirus Infections; Arboviruses; Autophagy; Autophagy-Related Proteins; Beclin-1; Cell Line; Chloroquine; Female; Gene Expression Regulation; Male; Phylogeny; Real-Time Polymerase Chain Reaction; RNA, Small Interfering | 2021 |
Fucoidan Inhibits NLRP3 Inflammasome Activation by Enhancing p62/SQSTM1-Dependent Selective Autophagy to Alleviate Atherosclerosis.
Topics: Adenine; Animals; Atherosclerosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Gene Knockdown Techniques; Humans; Inflammasomes; Lipid Metabolism; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; NLR Family, Pyrin Domain-Containing 3 Protein; Plaque, Atherosclerotic; Polysaccharides; Sequestosome-1 Protein; Sirolimus | 2020 |
FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy.
Topics: Adenine; Adult; Airway Remodeling; Animals; Autophagy; Biomarkers; Bronchoalveolar Lavage Fluid; Cigarette Smoking; Cytokines; Disease Models, Animal; Female; Follistatin-Related Proteins; Humans; Inflammation; Lung; Male; Mice; Mice, Inbred C57BL; Middle Aged; Pulmonary Disease, Chronic Obstructive | 2021 |
Polygoni Multiflori Radix Preparat Delays Skin Aging by Inducing Mitophagy.
Topics: Adenine; Aging; Animals; Antioxidants; Apoptosis; Drugs, Chinese Herbal; Fallopia multiflora; Male; Membrane Potential, Mitochondrial; Mitophagy; Rats; Sirolimus; Skin; Skin Aging | 2021 |
Effects of autophagy inhibitor 3-Methyladenine on ischemic stroke: A protocol for systematic review and meta-analysis.
Topics: Adenine; Animals; Autophagy; Brain Infarction; Clinical Protocols; Ischemic Stroke; Meta-Analysis as Topic; Models, Animal; Neurons; Research Design; Systematic Reviews as Topic | 2021 |
Puerarin plays a protective role in chondrocytes by activating Beclin1-dependent autophagy.
Topics: Adenine; Animals; Autophagy; Beclin-1; Cartilage, Articular; Cells, Cultured; Chondrocytes; Isoflavones; Mice; Osteoarthritis | 2021 |
Suppression of steroid 5α-reductase type I promotes cellular apoptosis and autophagy via PI3K/Akt/mTOR pathway in multiple myeloma.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; 5-alpha Reductase Inhibitors; Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Dutasteride; Enzyme Repression; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Inbred NOD; Multiple Myeloma; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Blockage of AMPK-ULK1 pathway mediated autophagy promotes cell apoptosis to increase doxorubicin sensitivity in breast cancer (BC) cells: an in vitro study.
Topics: Adenine; AMP-Activated Protein Kinases; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Intracellular Signaling Peptides and Proteins; Signal Transduction | 2021 |
Autophagy contributes to angiotensin II induced dysfunction of HUVECs.
Topics: Acetophenones; Adenine; Angiotensin II; Animals; Autophagosomes; Autophagy; Autophagy-Related Proteins; Benzimidazoles; Biphenyl Compounds; Decanoic Acids; Human Umbilical Vein Endothelial Cells; Humans; Hydroxy Acids; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Signal Transduction; Sirolimus; Tetrazoles; Time Factors | 2021 |
Autophagy Induction by α-Santalol in Human Prostate Cancer Cells.
Topics: Adenine; Apoptosis; Autophagy; Cell Line, Tumor; Humans; Male; Microtubule-Associated Proteins; Phosphorylation; Polycyclic Sesquiterpenes; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation.
Topics: Adenine; Animals; Autophagy; Beclin-1; Benzylamines; Cell Differentiation; Cell Line; Cell Proliferation; Estradiol; Female; Mice; Osteoblasts; Osteogenesis; Ovariectomy; Parathyroid Hormone; Quinazolines; Rats, Sprague-Dawley | 2021 |
Melatonin regulates the cross-talk between autophagy and apoptosis by SIRT3 in testicular Leydig cells.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cadmium; Cells, Cultured; Gene Knockdown Techniques; Leydig Cells; Male; Melatonin; Mice; Rats, Sprague-Dawley; Sirtuin 3; Sirtuins; Testis | 2021 |
CAPN1 (Calpain1)-Mediated Impairment of Autophagic Flux Contributes to Cerebral Ischemia-Induced Neuronal Damage.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 5; Beclin-1; Brain Ischemia; Calpain; Dipeptides; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Signal Transduction | 2021 |
25-Hydroxycholesterol mitigates hepatic ischemia reperfusion injury via mediating mitophagy.
Topics: Adenine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Disease Models, Animal; Hydroxycholesterols; Liver Diseases; Male; Mitophagy; NLR Family, Pyrin Domain-Containing 3 Protein; Protective Agents; Protein Kinases; Rats, Sprague-Dawley; Reperfusion Injury; Ubiquitin-Protein Ligases | 2021 |
Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells.
Topics: Adenine; Adenosine Monophosphate; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Autophagy; Beclin-1; Caspase 3; Cell Line, Tumor; Cell Survival; Humans; Microtubule-Associated Proteins; Multiple Myeloma; Phosphorylation; Resveratrol; Signal Transduction; TOR Serine-Threonine Kinases | 2021 |
Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms.
Topics: Adenine; Anthracenes; Autophagy; Berberine; Cell Proliferation; Cell Survival; Endothelial Cells; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; MAP Kinase Signaling System; Protective Agents; Sirolimus | 2021 |
Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy.
Topics: Adenine; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Autoantibodies; Autophagy; Cell Line, Tumor; Cell Survival; Diabetes Mellitus, Experimental; Immunization; Immunoglobulin G; Insulin Secretion; Insulin-Secreting Cells; Male; Rats; Receptor, Angiotensin, Type 1; Signal Transduction; Telmisartan; Up-Regulation | 2021 |
PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells.
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Breast Neoplasms; Cell Line, Tumor; Chloroquine; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation, Neoplastic; Humans; Isoflavones; Membrane Potential, Mitochondrial; Mitochondria; Mitophagy; Protein Kinases; Reactive Oxygen Species; Ubiquitin-Protein Ligases | 2021 |
Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats.
Topics: Adenine; Animals; Autophagy; Drug Tolerance; Imatinib Mesylate; Imidazoles; Injections, Spinal; Male; MAP Kinase Signaling System; Microglia; Minocycline; Morphine; Narcotics; Neurons; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta | 2021 |
Narciclasine attenuates sepsis-induced myocardial injury by modulating autophagy.
Topics: Adenine; Amaryllidaceae Alkaloids; Animals; Autophagy; Inflammation; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Myocytes, Cardiac; Phenanthridines; Sepsis; Up-Regulation | 2021 |
Androgen receptor inhibition alleviated inflammation in experimental autoimmune myocarditis by increasing autophagy in macrophages.
Topics: Adenine; Androgen Receptor Antagonists; Animals; Anti-Inflammatory Agents; Apoptosis; Autoimmune Diseases; Autophagy; Curcumin; Disease Models, Animal; Macrophages; Male; Mice, Inbred BALB C; Myocarditis; Myocardium | 2021 |
MiR-513b-5p represses autophagy during the malignant progression of hepatocellular carcinoma by targeting PIK3R3.
Topics: Adenine; Apoptosis; Autophagy; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Humans; Liver Neoplasms; MicroRNAs; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases | 2021 |
Fucoidan reduces lipid accumulation by promoting foam cell autophagy via TFEB.
Topics: Adenine; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Survival; Foam Cells; Lipid Metabolism; Lipoproteins, LDL; Macrolides; Mice; Polysaccharides; RAW 264.7 Cells | 2021 |
The effects of mTOR or Vps34-mediated autophagy on methylmercury-induced neuronal apoptosis in rat cerebral cortex.
Topics: Adenine; Animals; Apoptosis; Autophagy; Cerebral Cortex; Class III Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Female; Male; Methylmercury Compounds; Neurons; Rats, Wistar; Sirolimus; TOR Serine-Threonine Kinases | 2021 |
Letter on Rapamycin and 3-Methyladenine Influence the Apoptosis, Senescence, and Adipogenesis of Human Adipose-Derived Stem Cells by Promoting and Inhibiting Autophagy: An In Vitro and In Vivo Study.
Topics: Adenine; Adipogenesis; Apoptosis; Autophagy; Cells, Cultured; Humans; Sirolimus; Stem Cells | 2022 |
3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms.
Topics: Adenine; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Death; Deoxyglucose; JNK Mitogen-Activated Protein Kinases; Mechanistic Target of Rapamycin Complex 1; Melanoma; Melanoma, Experimental; Mice, Inbred C57BL; Mitochondria; Mitochondrial Swelling; Necrosis; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rotenone | 2021 |
Applicability of different cell line-derived dendritic cell-like cells in autophagy research.
Topics: Adenine; Autophagy; Autophagy-Related Proteins; Cell Differentiation; Cytokines; Dendritic Cells; Flow Cytometry; Genotype; HL-60 Cells; Humans; Macrolides; Microscopy, Fluorescence; Monocytes; Phenotype; Polymorphism, Single Nucleotide; Sirolimus; THP-1 Cells; U937 Cells | 2021 |
Sex-Specific Differences in Autophagic Responses to Experimental Ischemic Stroke.
Topics: Adenine; Animals; Autophagy; Autophagy-Related Protein 7; Autophagy-Related Protein-1 Homolog; Beclin-1; Brain Ischemia; Cell Hypoxia; Cell Survival; Female; Gene Expression Regulation; Glucose; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neurons; Ovariectomy; Sequestosome-1 Protein; Severity of Illness Index; Sex Factors; Signal Transduction | 2021 |
The negative effect of the PI3K inhibitor 3-methyladenine on planarian regeneration via the autophagy signalling pathway.
Topics: Adenine; Animals; Autophagy; Brain; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Planarians; Regeneration | 2021 |
A joint strategy comprising melatonin and 3-methyladenine to concurrently stimulate biomass and astaxanthin hyperaccumulation by Haematococcus pluvialis.
Topics: Adenine; Biomass; Chlorophyceae; Melatonin; Xanthophylls | 2021 |
Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models.
Topics: Adenine; Animals; Animals, Genetically Modified; Antioxidants; Antiparkinson Agents; Astrocytes; Autophagy; Behavior, Animal; Dihydroxyphenylalanine; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Male; Motor Activity; Nerve Degeneration; NF-E2-Related Factor 2; Oleanolic Acid; Parkinsonian Disorders; Phenotype; Rats, Sprague-Dawley; Repressor Proteins; Rotenone; Signal Transduction; Sirolimus | 2021 |
Restoration of Parkinson's Disease-Like Deficits by Activating Autophagy through mTOR-Dependent and mTOR-Independent Mechanisms in Pharmacological and Transgenic Models of Parkinson's Disease in Mice.
Topics: Adenine; Animals; Autophagy; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Transgenic; MTOR Inhibitors; Neuroinflammatory Diseases; Neuroprotective Agents; Parkinson Disease; Parkinson Disease, Secondary; Signal Transduction; Sirolimus; Substantia Nigra; TOR Serine-Threonine Kinases; Trehalose | 2021 |
Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL-33 signaling in a mouse model of skin wound healing.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Autophagy; Disease Models, Animal; Inflammation; Interleukin-33; Male; Mice; Mice, Inbred ICR; Signal Transduction; Sirolimus; Skin; Wound Healing; YAP-Signaling Proteins | 2021 |
Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling.
Topics: Adenine; Autophagy; Autophagy-Related Protein 5; Cancer-Associated Fibroblasts; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chloroquine; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; HMGB1 Protein; Humans; Lung Neoplasms; Microtubule-Associated Proteins; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Recombinant Proteins; Signal Transduction | 2021 |
Enhanced Cancer Starvation Therapy Based on Glucose Oxidase/3-Methyladenine-Loaded Dendritic Mesoporous OrganoSilicon Nanoparticles.
Topics: Adenine; Animals; Cell Line, Tumor; Cell Proliferation; Dendrimers; Female; Glucose Oxidase; Humans; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Organosilicon Compounds; Porosity | 2021 |
An imbalance in autophagy contributes to retinal damage in a rat model of oxygen-induced retinopathy.
Topics: Adenine; Animals; Autophagy; Biomarkers; Disease Susceptibility; Humans; Infant, Newborn; Oxygen; Rats; Retina; Retinal Diseases; Signal Transduction | 2021 |
Differential Ubiquitination as an Effective Strategy Employed by the Blood-Brain Barrier for Prevention of Bacterial Transcytosis.
Topics: Adenine; Anti-Bacterial Agents; Autophagy; Biomarkers; Blood-Brain Barrier; Cell Line; Cell Survival; Endothelial Cells; Gene Expression Regulation, Bacterial; Gentamicins; Humans; Leupeptins; Optical Imaging; Penicillins; Proteasome Endopeptidase Complex; Streptococcus pneumoniae; Ubiquitination; Ubiquitins | 2022 |
Curcumin induces autophagic cell death in human thyroid cancer cells.
Topics: Adenine; Antineoplastic Agents; Autophagic Cell Death; Cell Line; Cell Line, Tumor; Cell Survival; Cells, Cultured; Curcumin; Humans; Proto-Oncogene Proteins c-akt; Signal Transduction; Thyroid Neoplasms; TOR Serine-Threonine Kinases | 2022 |
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Topics: Acetylcysteine; Adenine; Antioxidants; Autophagic Cell Death; Autophagosomes; Carcinoma, Hepatocellular; DNA Damage; Hep G2 Cells; Humans; Liver Neoplasms; Lysosomes; Microtubule-Associated Proteins; Mitochondria; Naphthalimides; Proteome; Proteomics; Reactive Oxygen Species; Sequestosome-1 Protein | 2021 |
Activation of the autophagy pathway decreases dengue virus infection in Aedes aegypti cells.
Topics: Adenine; Aedes; Animals; Autophagy; Cell Line; Dengue; Dengue Virus; Mosquito Vectors; Sirolimus; Virus Replication | 2021 |
Comparative transcriptomic and metabolic profiling provides insight into the mechanism by which the autophagy inhibitor 3-MA enhances salt stress sensitivity in wheat seedlings.
Topics: Adenine; Autophagy; Gene Expression Profiling; Gene Expression Regulation, Plant; Metabolome; Plant Leaves; Plant Roots; Reactive Oxygen Species; Salt Stress; Salt Tolerance; Seedlings; Triticum | 2021 |
Anticachectic regulator analysis reveals Perp-dependent antitumorigenic properties of 3-methyladenine in pancreatic cancer.
Topics: Adenine; Age Factors; Animals; Autophagy; Cachexia; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Gene Expression Profiling; Humans; Membrane Proteins; Mice; Muscle, Skeletal; Pancreatic Neoplasms | 2022 |
Octreotide activates autophagy to alleviate lipopolysaccharide-induced human pulmonary epithelial cell injury by inhibiting the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway.
Topics: Acetates; Adenine; Autophagy; Benzopyrans; Cell Line; Cell Survival; Humans; Lipopolysaccharides; Lung Injury; Models, Biological; Octreotide; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2022 |
Autophagy facilitates age-related cell apoptosis-a new insight from senile cataract.
Topics: Adenine; Adult; Aged; Aging; Apoptosis; Autophagy; Cataract; Cell Survival; Cells, Cultured; Cellular Senescence; Humans; Lens, Crystalline; Middle Aged; NF-kappa B; Oxidative Stress; Sequestosome-1 Protein; Signal Transduction; Young Adult | 2022 |
Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Cell Line, Tumor; Cell Survival; Class III Phosphatidylinositol 3-Kinases; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Forkhead Box Protein O1; Humans; Microtubule-Associated Proteins; Paclitaxel; Triple Negative Breast Neoplasms | 2022 |
Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells.
Topics: Adenine; Animals; Asthma; Bronchi; Bronchoalveolar Lavage Fluid; Cell Line; Cyclohexylamines; Cytokines; Disease Models, Animal; Epithelial Cells; Ferroptosis; Humans; Injections, Intraperitoneal; Interleukin-13; Male; Mice; Mice, Inbred C57BL; Ovalbumin; Oxidative Stress; Phenylenediamines; Signal Transduction | 2022 |
Effects of 3-methyladenine, an autophagy inhibitor, on the elevated blood pressure and arterial dysfunction of angiotensin II-induced hypertensive mice.
Topics: Adenine; Angiotensin II; Animals; Autophagy; Beclin-1; Blood Pressure; Endothelium, Vascular; Hypertension; Mesenteric Arteries; Mice; Nitric Oxide; Vasodilation | 2022 |