adenine has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.89) | 18.2507 |
| 2000's | 15 (39.47) | 29.6817 |
| 2010's | 20 (52.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blommaart, EF; Krause, U; Meijer, AJ; Schellens, JP; Vreeling-Sindelárová, H | 1 |
| Carnero, A; Lacal, JC | 1 |
| Chiba, K; Hoshi, M; Katada, T; Kontani, K; Kurosu, H; Nakano, T | 1 |
| Backer, JM; Brachmann, SM; Cooper, J; Eskelinen, EL; Lucocq, JM; Prescott, AR; Tang, X; Wang, L | 1 |
| Di-Segni, A; Lupowitz, Z; Pinkas-Kramarski, R; Tal-Or, P | 1 |
| Dick, K; Sadhu, C; Staunton, DE; Tino, WT | 1 |
| Andersson, TP; Sköld, HN; Svensson, SP | 1 |
| Baizabal, JM; Cárdenas-Aguayo, Mdel C; Covarrubias, L; Salgado, LM; Santa-Olalla, J | 1 |
| Hayflick, JS; Northcott, CA; Watts, SW | 1 |
| Fujita, H; Himeno, M; Hirosako, K; Hirota, Y; Imasato, H; Kuronita, T; Masuyama, N; Nishioka, M; Tanaka, Y; Umeda, A | 1 |
| Hayflick, J; Northcott, CA; Watts, SW | 1 |
| Ferreira, AM; Hayflick, JS; Isaacs, H; Rogers, KA; Sandig, M | 1 |
| Brown, NS; Dice, JF; Finn, PF; Franch, HA; Shen, W | 1 |
| Araki, N; Egami, Y; Hamasaki, M; Hatae, T | 1 |
| Ito, S; Koshikawa, N; Mochizuki, S; Takenaga, K | 1 |
| Zeng, M; Zhou, JN | 1 |
| Blagbrough, IS; Farghaly, HS; Medina-Tato, DA; Watson, ML | 1 |
| Andina, N; Dahinden, CA; Didichenko, S; Schmidt-Mende, J; Simon, HU | 1 |
| Chrysanthopoulou, A; Kambas, K; Kourtzelis, I; Mitroulis, I; Rafail, S; Ritis, K; Speletas, M | 1 |
| Box, AH; Demetrick, DJ; Kim, SM | 1 |
| Knight, ZA | 1 |
| Black, JL; Burgess, JK; Ge, Q; Moir, LM; Niimi, K; Oliver, BG; Poniris, M; Shepherd, PR; Trian, T | 1 |
| Barnes, PJ; Ito, K; Ito, M; Osoata, G; Rossios, C; To, Y | 1 |
| Cheng, E; Ganaie, SS; Haque, A; Hussein, IT; Mir, MA; Sheema, S; Werle, MJ | 1 |
| Dickman, MB; Kabbage, M; Williams, B | 1 |
| Dixon, SJ; Jirik, FR; Kashishian, A; Lannutti, BJ; Pereverzev, A; Puri, KD; Shugg, RP; Sims, SM; Steiner, BH; Tanabe, N; Thomson, A | 1 |
| Hellman, U; Kazi, JU; Lundby, A; Mohlin, S; Olsen, JV; Påhlman, S; Rönnstrand, L; Sun, J | 1 |
| Eräsalo, H; Hämäläinen, M; Laavola, M; Leppänen, T; Moilanen, E; Nieminen, R | 1 |
| Badolia, R; Dangelmaier, C; Eble, JA; Ellmeier, W; Kahn, M; Kunapuli, SP; Manne, BK | 1 |
| Leoncini, G; Signorello, MG | 1 |
| Baek, E; Kim, CL; Kim, MG; Lee, GM; Lee, JS | 1 |
| Chen, L; Fang, Y; Fei, W; Han, W; Jing, Z; Liang, X; Pan, H; Sui, X; Xie, J; Zhang, L; Zhang, X; Zhou, J | 1 |
| Hee Kim, Y; Jun, do Y; Kim, JS; Kim, KY; Kim, YH | 1 |
| Hu, L; Huang, L; Wang, H; Wang, J; Zhao, Y | 1 |
| Guo, Y; Lu, J; Qian, P; Tao, H; Wang, F; Zhu, H | 1 |
| Chen, D; Chen, Z; Dai, C; Han, Z; He, F; Li, Y; Tan, R; Tian, H; Wang, G; Wang, M; Wei, L; Yang, B; Yang, H; Zhang, B | 1 |
| Gao, D; Li, S; Sun, H; Tang, T; Tang, Y; Zhu, J | 1 |
| Gupta, P; Mukhopadhyay, CK; Pandey, HS; Seth, P; Singh, P | 1 |
1 review(s) available for adenine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Small molecule inhibitors of the PI3-kinase family.
Topics: Adenine; Androstadienes; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromones; DNA-Activated Protein Kinase; DNA-Binding Proteins; Humans; Morpholines; Neoplasms; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolines; Tumor Suppressor Proteins; Wortmannin | 2010 |
37 other study(ies) available for adenine and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
Topics: Adenine; Androstadienes; Animals; Autophagy; Cell Membrane; Cells, Cultured; Chromones; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Inhibitors; Liver; Male; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Signal Transduction; Starvation; Wortmannin | 1997 |
Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Kinetics; Maturation-Promoting Factor; Morpholines; Oocytes; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Wortmannin; Xenopus laevis | 1998 |
G-protein betagamma subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine.
Topics: Adenine; Androstadienes; Animals; Chromones; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; GTP-Binding Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Microinjections; Morpholines; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Signal Transduction; Starfish; Time Factors; Wortmannin | 1999 |
Inhibition of autophagy in mitotic animal cells.
Topics: Adenine; Anaphase; Androstadienes; Animals; Autophagy; Blotting, Western; Cell Line; Chromones; Endoplasmic Reticulum; Enzyme Inhibitors; Golgi Apparatus; HeLa Cells; Humans; Immunohistochemistry; Metaphase; Microscopy, Immunoelectron; Microscopy, Phase-Contrast; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Telophase; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2002 |
Neuregulin promotes autophagic cell death of prostate cancer cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Autophagy; Cell Death; Cell Division; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Ligands; Male; Morpholines; Neuregulins; Phosphorylation; Prostatic Neoplasms; Tumor Cells, Cultured; Tyrosine | 2003 |
Selective role of PI3K delta in neutrophil inflammatory responses.
Topics: Adenine; Androstadienes; Animals; Anti-Inflammatory Agents; Chromones; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exocytosis; Inflammation; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Morpholines; Neutrophils; Phosphatidylinositol 3-Kinases; Protein Isoforms; Quinazolines; Signal Transduction; Superoxides; Time Factors; Wortmannin | 2003 |
Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Androstadienes; Animals; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Kinetics; Melanocyte-Stimulating Hormones; Melanophores; Melanosomes; Melatonin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Norepinephrine; Papaverine; Perciformes; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Phosphoric Diester Hydrolases; Phosphorylation; Rolipram; Signal Transduction; Wortmannin; Xenopus laevis | 2003 |
Growth factor deprivation induces an alternative non-apoptotic death mechanism that is inhibited by Bcl2 in cells derived from neural precursor cells.
Topics: Adenine; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Caspase Inhibitors; Cell Death; Cell Differentiation; Cell Survival; Chromones; Cycloheximide; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblast Growth Factor 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Green Fluorescent Proteins; Immunohistochemistry; Intermediate Filament Proteins; Luminescent Proteins; Mesencephalon; Mice; Microscopy, Electron; Morpholines; Nerve Tissue Proteins; Nestin; Neurons; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Stem Cells; Transformation, Genetic; Tubulin; Vacuoles | 2003 |
PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110delta the culprit?
Topics: Adenine; Animals; Aorta; Chromones; Class I Phosphatidylinositol 3-Kinases; Desoxycorticosterone; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Subunits; Quinazolines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vascular Resistance | 2004 |
3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN.
Topics: Adenine; Androstadienes; Animals; Biological Transport; Cations; Cell Line; Chromones; Endosomes; Enzyme Inhibitors; Liver; Lysosomes; Mannosephosphates; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Rats; Receptor, IGF Type 2; Subcellular Fractions; Time Factors; trans-Golgi Network; Transferrin; Wortmannin | 2004 |
Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility.
Topics: Adenine; Animals; Aorta; Blotting, Western; Chromones; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Immunohistochemistry; In Vitro Techniques; Male; Morpholines; Norepinephrine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents | 2005 |
The p110delta isoform of PI3K differentially regulates beta1 and beta2 integrin-mediated monocyte adhesion and spreading and modulates diapedesis.
Topics: Adenine; Androstadienes; CD18 Antigens; cdc42 GTP-Binding Protein; Cell Line; Cell Movement; Chromones; Class I Phosphatidylinositol 3-Kinases; Gene Expression Regulation; Humans; Integrin alpha4beta1; Integrin beta1; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Monocytes; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; rac1 GTP-Binding Protein; Signal Transduction; Vascular Cell Adhesion Molecule-1; Wortmannin | 2006 |
Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
Topics: Acetylcysteine; Adenine; Animals; Autophagy; Cell Line; Chromones; Epidermal Growth Factor; Glyceraldehyde-3-Phosphate Dehydrogenases; Kidney Tubules; Leupeptins; Lysosomes; Methylamines; Morpholines; PAX2 Transcription Factor; Peptide Hydrolases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2006 |
Effect of 3-methyladenine on the fusion process of macropinosomes in EGF-stimulated A431 cells.
Topics: Adenine; Androstadienes; Cell Line, Tumor; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Humans; Membrane Fusion; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Pinocytosis; Vesicular Transport Proteins; Wortmannin | 2006 |
3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition.
Topics: Actins; Adenine; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Survival; Chromones; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors | 2007 |
Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells.
Topics: Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Carrier Proteins; Cell Differentiation; Cell Line, Tumor; Cell Size; Chromones; Dose-Response Relationship, Drug; Down-Regulation; Mice; Morpholines; Neurites; Neuroblastoma; Neurons; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Proteins; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tretinoin | 2008 |
Interleukin 13 increases contractility of murine tracheal smooth muscle by a phosphoinositide 3-kinase p110delta-dependent mechanism.
Topics: Adenine; Animals; Bronchial Hyperreactivity; Carbachol; Chromones; Class I Phosphatidylinositol 3-Kinases; In Vitro Techniques; Interleukin-13; Isoenzymes; Lung; Mice; Mice, Mutant Strains; Morpholines; Muscle Contraction; Muscle, Smooth; Mutant Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Tissue Extracts; Trachea | 2008 |
Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.
Topics: Adenine; Androstadienes; Apoptosis; Cells, Cultured; Chromones; Eosinophils; Humans; Hypersensitivity; Interleukin-5; Janus Kinase 2; Microscopy, Confocal; Morpholines; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-pim-1; Quinazolines; Tyrphostins; Wortmannin; Xanthenes | 2009 |
Regulation of the autophagic machinery in human neutrophils.
Topics: Adenine; Autophagy; Cadaverine; Chromones; Coloring Agents; Escherichia coli; Guanosine; Humans; Hydrogen-Ion Concentration; Inflammation; Microscopy, Confocal; Morpholines; Neutrophils; Phagosomes; Poly I-C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sirolimus; Small Ubiquitin-Related Modifier Proteins; Tetradecanoylphorbol Acetate; Toll-Like Receptors; Transcription, Genetic; Vacuoles | 2010 |
AKT loss in human epithelial cells treated with severe hypoxia.
Topics: Adenine; Autophagy; Calpain; Chromones; Enzyme Inhibitors; Epithelial Cells; HeLa Cells; Humans; Hypoxia; Intracellular Signaling Peptides and Proteins; Morpholines; Oxygen; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2010 |
The phosphoinositide 3'-kinase p110δ modulates contractile protein production and IL-6 release in human airway smooth muscle.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Asthma; Benzamides; Cells, Cultured; Chromones; Class I Phosphatidylinositol 3-Kinases; Contractile Proteins; Dioxoles; Female; Gene Expression Regulation; Humans; Interleukin-6; Lung; Male; Middle Aged; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Pulmonary Disease, Chronic Obstructive; Quinazolines; Tissue Donors; Transforming Growth Factor beta1 | 2012 |
Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenine; Adrenal Cortex Hormones; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Albuterol; Androstadienes; Asthma; Budesonide; Chromones; Dexamethasone; Drug Resistance; Ethanolamines; Female; Fluticasone; Formoterol Fumarate; Humans; Hydrogen Peroxide; Interleukin-8; Leukocytes, Mononuclear; Male; Middle Aged; Morpholines; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Receptors, Adrenergic, beta-2; Salmeterol Xinafoate; U937 Cells; Young Adult | 2012 |
Autophagic clearance of Sin Nombre hantavirus glycoprotein Gn promotes virus replication in cells.
Topics: Adenine; Androstadienes; Animals; Autophagy; Autophagy-Related Protein 7; Cell Line; Chlorocebus aethiops; Chromones; Glycoproteins; HeLa Cells; Humans; Morpholines; Proteolysis; RNA Interference; RNA, Small Interfering; Sin Nombre virus; Ubiquitin-Activating Enzymes; Vero Cells; Viral Envelope Proteins; Virus Replication; Wortmannin | 2012 |
Cell death control: the interplay of apoptosis and autophagy in the pathogenicity of Sclerotinia sclerotiorum.
Topics: Adenine; Androstadienes; Antifungal Agents; Apoptosis; Arabidopsis; Ascomycota; Autophagy; Chloroquine; Chromones; Host-Pathogen Interactions; Morpholines; Mycoses; Oxalic Acid; Plant Diseases; Reactive Oxygen Species; Respiratory Burst; Wortmannin | 2013 |
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
Topics: Adenine; Androstadienes; Animals; Bone Resorption; Cell Survival; Chromones; Cytoskeleton; Indazoles; Isoenzymes; Morpholines; Osteoclasts; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolines; Rabbits; RANK Ligand; Rats; Sulfonamides; Wortmannin | 2013 |
The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.
Topics: Adenine; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; Class Ia Phosphatidylinositol 3-Kinase; COS Cells; Female; Mice, Inbred Strains; Mice, Nude; Morpholines; Mutation, Missense; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-kit; Quinazolines; RNA Interference; Serine; Tyrosine | 2014 |
PI3K inhibitors LY294002 and IC87114 reduce inflammation in carrageenan-induced paw oedema and down-regulate inflammatory gene expression in activated macrophages.
Topics: Adenine; Animals; Carrageenan; Chemokine CCL2; Chromones; Down-Regulation; Edema; Enzyme Inhibitors; Inflammation; Interleukin-6; Macrophages; Mice; Morpholines; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Tumor Necrosis Factor-alpha | 2015 |
Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Amino Acid Motifs; Animals; Blood Platelets; Chromones; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Lectins, C-Type; Membrane Glycoproteins; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Piperidines; Platelet Activation; Platelet Membrane Glycoproteins; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Signal Transduction; Syk Kinase; Tyrosine | 2015 |
Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Arachidonic Acids; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Cannabinoid Receptor Agonists; Cells, Cultured; Chromones; Cyclic AMP; Dose-Response Relationship, Drug; Endocannabinoids; Estrenes; Fatty Acids, Unsaturated; Glycerides; Humans; Hydrazines; Immunoblotting; Indoles; Intracellular Space; Maleimides; Milrinone; Morpholines; Phosphatidylinositol 3-Kinases; Phosphodiesterase 3 Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Protein Kinase C; Pyrrolidinones; Receptors, Thromboxane; Type C Phospholipases | 2016 |
Chemical inhibition of autophagy: Examining its potential to increase the specific productivity of recombinant CHO cell lines.
Topics: Adenine; Androstadienes; Animals; Autophagy; Bioreactors; Cell Culture Techniques; CHO Cells; Chromones; Cricetinae; Cricetulus; Morpholines; Recombinant Proteins; Wortmannin | 2016 |
Salvianolic acid B, a novel autophagy inducer, exerts antitumor activity as a single agent in colorectal cancer cells.
Topics: Adenine; Animals; Antineoplastic Agents; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Benzofurans; Chromones; Colorectal Neoplasms; Drugs, Chinese Herbal; Female; HCT116 Cells; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Morpholines; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Salvia miltiorrhiza; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Inhibition of autophagy enhances dynamin inhibitor-induced apoptosis via promoting Bak activation and mitochondrial damage in human Jurkat T cells.
Topics: Adenine; Annexin A5; Apoptosis; Autophagy; bcl-2 Homologous Antagonist-Killer Protein; Caspases; Cell Cycle; Cell Survival; Chromones; DNA Fragmentation; Dynamins; Flow Cytometry; Fluorescein-5-isothiocyanate; Humans; Jurkat Cells; Membrane Potential, Mitochondrial; Mitochondria; Morpholines; Trimethyl Ammonium Compounds | 2016 |
The Protective Roles of ROS-Mediated Mitophagy on
Topics: Adenine; Adenosine Triphosphate; Apoptosis; Chromones; Flow Cytometry; Gamma Rays; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iodine Radioisotopes; Membrane Potential, Mitochondrial; Membrane Proteins; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Microtubule-Associated Proteins; Mitochondria; Mitophagy; Morpholines; Oxidative Stress; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Tumor Suppressor Proteins | 2016 |
Autophagy inhibition enhances radiosensitivity of Eca‑109 cells via the mitochondrial apoptosis pathway.
Topics: Adenine; Animals; Autophagy; Cell Line, Tumor; Chromones; Esophageal Neoplasms; Gene Regulatory Networks; Humans; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Morpholines; Radiation Tolerance; Xenograft Model Antitumor Assays | 2018 |
Autophagy and Akt in the protective effect of erythropoietin helix B surface peptide against hepatic ischaemia/reperfusion injury in mice.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Cell Line; Chemical and Drug Induced Liver Injury; Chromones; Cobalt; Disease Models, Animal; Erythropoietin; Humans; Liver; Liver Function Tests; Mice; Mice, Inbred C57BL; Morpholines; Peptide Fragments; Proto-Oncogene Proteins c-akt; Random Allocation; Reperfusion Injury; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2018 |
CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.
Topics: Adenine; Animals; Autophagy; Cell Movement; Cell Proliferation; Chemokine CXCL12; Chromones; Cranial Nerves; Disease Models, Animal; Facial Nerve; Facial Nerve Injuries; Gene Expression Regulation; Humans; Insulin-Like Growth Factor I; Male; Microtubule-Associated Proteins; Morpholines; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Isoforms; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Schwann Cells; Signal Transduction; TOR Serine-Threonine Kinases | 2019 |
Phosphoinositide-3-kinase inhibition elevates ferritin level resulting depletion of labile iron pool and blocking of glioma cell proliferation.
Topics: Adenine; Animals; Brain Neoplasms; Cell Proliferation; Cells, Cultured; Chromones; Down-Regulation; Ferritins; Glioma; Humans; Iron; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Pyrimidinones; Quinazolines; Rats; Thiazolidinediones; Up-Regulation | 2019 |