adefovir dipivoxil has been researched along with adefovir in 30 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (30.00) | 18.2507 |
| 2000's | 14 (46.67) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Hitchcock, MJ; Mansuri, MM; Martin, JC; Russell, J; Starrett, JE; Tortolani, DR; Whiterock, V | 1 |
| Aubertin, AM; Benzaria, S; Gosselin, G; Imbach, JL; Johnson, R; Maury, G; Obert, G; Pélicano, H | 1 |
| Balzarini, J; Görbig, U; Meier, C; Müller, C | 1 |
| Beadle, JR; Bradley, M; Farasati, NA; Hostetler, KY; Huang, Y; Meier, C; Randhawa, P; Sauerbrei, A; Zemlicka, J | 1 |
| Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E | 1 |
| Cheviet, T; Lefebvre-Tournier, I; Peyrottes, S; Wein, S | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Cundy, KC; Fishback, JA; Lee, ML; Lee, WA; Shaw, JP; Soike, KF; Visor, GC | 1 |
| Franková, D; Holý, A; Otová, B; Zídek, A | 1 |
| Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L | 1 |
| Annaert, P; Augustijns, P; de Clercq, E; Kinget, R; Naesens, L | 1 |
| Annaert, P; Augustijns, P; Benzaria, S; de Clercq, E; Gosselin, G; Hatse, S; Imbach, JL; Kinget, R; Naesens, L; Pompon, A; Valette, G; Van den Mooter, G | 1 |
| Balzarini, J; De Clercq, E; Hatse, S | 1 |
| Franková, D; Holý, A; Zídek, Z | 1 |
| Grande Santamaría, L; Romero Gómez, M; Suárez García, E | 1 |
| Chen, XY; Yang, HY; Zhang, Y; Zhao, LY; Zhong, DF | 1 |
| Bendayan, R; Dallas, S; Schlichter, L | 1 |
| Bergson, P; Gibbs, CS; Shen, Y; Soelaiman, S; Tang, WJ; Wang, CR; Zhukovskaya, NL; Zimmer, MI | 1 |
| Perelson, AS; Ribeiro, RM | 1 |
| Jiang, Y; Xu, Z; Zhang, X | 1 |
| Holý, A; Kmonícková, E; Zídek, Z | 1 |
| De Clercq, E | 1 |
| Anzenbacher, P; Anzenbacherová, E; Holý, A; Matal, J; Nekvindová, J; Orság, J; Veinlichová, A; Zídek, Z | 1 |
| Anzenbacher, P; Anzenbacherová, E; Holý, A; Masek, V; Nekvindová, J; Veinlichová, A; Zídek, Z | 1 |
| Chen, X; Ji, R; Liu, J; Lu, P; Wang, Y; Yang, Y | 1 |
| Chapy, H; Maeng, HJ; Pang, KS; Zaman, S | 1 |
| Fan, H; Fan, Y; Ge, Y; Li, D; Liu, X; Liu, Z; Lyu, W; Yang, H; Zhou, B | 1 |
| Dang, B; Kang, W; Liu, Q; Sun, Y; Wang, C; Yao, N; Yu, Z; Zhao, K | 1 |
| Choi, MK; Kim, SB; Maeng, HJ; Son, JH; Yoon, IS | 1 |
| Arai, K; Hayakawa, N; Honda, M; Horii, R; Kagaya, T; Kaneko, S; Kawaguchi, K; Komura, T; Mizukoshi, E; Nio, K; Nishikawa, M; Orita, N; Sakai, Y; Shimakami, T; Shimode, T; Takatori, H; Terashima, T; Yamashita, T | 1 |
2 review(s) available for adefovir dipivoxil and adefovir
| Article | Year |
|---|---|
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Topics: Antimalarials; Biological Transport; Drug Design; Erythrocytes; Humans; Inhibitory Concentration 50; Malaria; Nucleosides; Nucleotides; Plasmodium falciparum; Purines; Pyrimidines | 2019 |
Hepatitis B virus kinetics and mathematical modeling.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; Hepatocytes; Lamivudine; Models, Biological; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Load; Virion | 2004 |
28 other study(ies) available for adefovir dipivoxil and adefovir
| Article | Year |
|---|---|
Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Male; Organophosphonates; Prodrugs; Rats | 1994 |
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Topics: Adenine; Administration, Oral; Antiviral Agents; Biological Availability; Cell Line; Drug Stability; Herpesvirus 1, Human; Humans; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.
Topics: Acetylcholinesterase; Adenine; Anti-HIV Agents; Benzyl Alcohols; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; HIV-1; HIV-2; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 2005 |
Anti-BK virus activity of nucleoside analogs.
Topics: Adenine; BK Virus; Esters; Fatty Acids; Humans; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Virus Replication | 2008 |
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship | 2009 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adenine; Animals; Antiviral Agents; beta-Cyclodextrins; Biological Availability; Cyclodextrins; Macaca fascicularis; Male; Organophosphonates; Prodrugs; Propylene Glycols; Retroviridae; Suspensions | 1994 |
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1995 |
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; In Vitro Techniques; Leukemia, Experimental; Mice; Mice, Inbred Strains; Mice, SCID; Moloney murine sarcoma virus; Organophosphonates; Prodrugs; Rats; Retroviridae; Retroviridae Infections; Sarcoma, Experimental; Tumor Virus Infections | 1996 |
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Topics: Adenine; Animals; Antiviral Agents; Caco-2 Cells; Chromatography, High Pressure Liquid; Humans; Intestinal Absorption; Organophosphonates; Prodrugs; Swine | 1997 |
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Topics: Adenine; Antiviral Agents; Caco-2 Cells; Chromatography, Ion Exchange; Esters; Humans; Organophosphonates; Prodrugs | 1998 |
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine | 1998 |
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL5; Female; Fibrosis; Macrophages, Peritoneal; Nitric Oxide; Organ Size; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Inbred Lew; Spleen; Tenofovir | 1999 |
[Current treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Anti-Inflammatory Agents; Antiviral Agents; DNA Replication; Famciclovir; Forecasting; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Prednisone; Prognosis; Reverse Transcriptase Inhibitors; Time Factors; Virus Replication | 2001 |
[Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry].
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, Liquid; Macaca mulatta; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2003 |
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Humans; Microglia; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats; Rats, Wistar; RNA, Messenger; Tritium | 2004 |
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antigens, Bacterial; Antiviral Agents; Bacterial Toxins; Binding Sites; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Exotoxins; Hepatitis B, Chronic; Kinetics; Models, Molecular; Organophosphonates; Protein Conformation; Recombinant Proteins; Spodoptera; Transfection | 2004 |
[Determination of adefovir dipivoxil and its degradation products by reversed-phase high performance liquid chromatography].
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Indicators and Reagents; Organophosphonates | 2004 |
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Female; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors | 2005 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses | 2007 |
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Topics: Adenine; Bacteria; Cell Membrane; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Liver; Metabolic Detoxication, Phase I; Models, Biological; NADPH-Ferrihemoprotein Reductase; Organophosphonates; Oxygenases; Research Design; Tenofovir; Transformation, Bacterial | 2006 |
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Organophosphonates; Prodrugs; Tenofovir | 2006 |
Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Design; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2009 |
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.
Topics: Adenine; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cells, Cultured; Drug Interactions; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organophosphonates; Permeability; Verapamil; Vitamin D | 2012 |
[Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Treatment Outcome | 2014 |
[Efficacy and safety of telbivudine alone and combined with adefovir for the treatment of nucleos(t)ide-naive chronic hepatitis B in patients with high-level hepatitis B virus load].
Topics: Adenine; Alanine Transaminase; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2015 |
Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.
Topics: Adenine; Administration, Oral; Animals; Area Under Curve; Biological Availability; Calcitriol; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Aldo-keto reductase family 1 member B10 is regulated by nucleos(t)ide analogues for chronic hepatitis B.
Topics: Aldo-Keto Reductase Family 1 member B10; Aldo-Keto Reductases; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Tenofovir | 2023 |