adefovir has been researched along with zidovudine in 40 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (7.50) | 18.7374 |
1990's | 20 (50.00) | 18.2507 |
2000's | 12 (30.00) | 29.6817 |
2010's | 4 (10.00) | 24.3611 |
2020's | 1 (2.50) | 2.80 |
Authors | Studies |
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Bronson, JJ; Ghazzouli, I; Hitchcock, MJ; Kim, CU; Luh, BY; Martin, JC; Misco, PF | 1 |
Alvarez, K; Balzarini, J; Barral, K; Canard, B; Neyts, J; Priet, S; Sire, J | 1 |
Baba, M; De Clercq, E; Shi, M; Takao, S; Wang, X | 1 |
Beadle, JR; Bradley, M; Farasati, NA; Hostetler, KY; Huang, Y; Meier, C; Randhawa, P; Sauerbrei, A; Zemlicka, J | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Campillo, NE; Guerra, A; Páez, JA | 1 |
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Camarasa, MJ; de Castro, S | 1 |
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
Balzarini, J; Bergamini, A; Calio, R; De Clercq, E; Milanese, G; Pauwels, R; Perno, CF; Rocchi, G; Yarchoan, R | 1 |
Beer, B; Donath, A; Egberink, HF; Hartmann, K; Hoffmann-Fezer, G; Horzinek, MC; Lutz, H; Thefeld, S; Thum, I | 1 |
Egberink, HF; Hartman, K; Horzinek, MC | 1 |
Broder, S; Kageyama, S; Mitsuya, H; Yarchoan, R | 1 |
Balzarini, J; Bronson, R; De Clercq, E; Jaenisch, R; Lee, JS; Mullaney, S; Ruprecht, RM; Sharpe, AH | 1 |
Balzarini, J; Borst, M; De Clercq, E; Egberink, H; Horzinek, M; Koolen, M; Neu, H; Niphuis, H; Schellekens, H | 1 |
Bernaerts, R; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Votruba, I | 1 |
Balzarini, J; De Clercq, E; Naesens, L; Sobis, H; Vandeputte, M | 1 |
Balzarini, J; De Clercq, E; Naesens, L | 1 |
Brian, EL; De Clercq, E; Pagano, JS; Smith, MS | 1 |
Balzarini, J; Cozens, RM; De Clercq, E; Gangemi, JD; Hochkeppel, HK | 1 |
De Clercq, E; Gil-Fernández, C | 1 |
Fridland, A; Gong, YF; Marshall, DR; Srinivas, RV | 1 |
Aubertin, AM; Gosselin, G; Imbach, JL; Kirn, A; Lefebvre, I; Pompon, A; Puech, F | 1 |
Holý, A; Merta, A; Stĕtina, R; Votruba, I | 1 |
Ahmed, PS; Brennan, TM; Bridges, CG; Casara, P; Hornsperger, JM; Navé, JF; Taylor, DL; Tyms, AS | 1 |
Allen, SJ; Chen, MS; Cherrington, JM; Fuller, MD; Kunder, SC; Lesnikowski, Z; Mulato, AS; Schinazi, RF; Sommadossi, JP; Ussery, MA | 1 |
Baba, M; De Clercq, E; Makino, M; Okada, Y; Suruga, Y; Tanaka, H | 1 |
Balzarini, J; De Clercq, E; Hatse, S | 1 |
Connelly, MC; Flynn, PM; Fridland, A; Kumar, A; Paibir, SG; Schuetz, JD; Srinivas, RV; Sun, D | 1 |
Cheng, B | 1 |
Buckheit, R; Gilbert, H; Margot, N; Miller, M; Palmer, S; Shaw, N | 1 |
Ambudkar, SV; Nandigama, K; Sauna, ZE | 1 |
Abla, N; Chinn, LW; Ferrin, TE; Giacomini, KM; Huang, CC; Johns, SJ; Kawamoto, M; Kroetz, DL; Liu, L; Nakamura, T; Stryke, D; Taylor, TR | 1 |
Benoist, JF; Buck, NE; Hu, R; Ioannou, PA; Khaniani, MS; Li, L; Peters, HL; Sarsero, JP; Vadolas, J; Wardan, H; Wood, L | 1 |
Buck, NE; Hu, R; Peters, HL; Wood, L | 1 |
5 review(s) available for adefovir and zidovudine
Article | Year |
---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; Polypharmacology | 2018 |
Chemotherapy of feline immunodeficiency virus infection.
Topics: Adenine; Animals; Antiviral Agents; Cats; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Organophosphonates; Zidovudine | 1991 |
Targeted therapy of human immunodeficiency virus-related disease.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine | 1991 |
1 trial(s) available for adefovir and zidovudine
Article | Year |
---|---|
Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms.
Topics: Adenine; Animals; Antiviral Agents; Cats; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Feline Acquired Immunodeficiency Syndrome; Gene Products, gag; Hematocrit; Immunodeficiency Virus, Feline; Injections, Subcutaneous; Leukemia Virus, Feline; Leukemia, Feline; Organophosphonates; T-Lymphocytes, Regulatory; Zidovudine | 1992 |
34 other study(ies) available for adefovir and zidovudine
Article | Year |
---|---|
Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships.
Topics: Antiviral Agents; Chemical Phenomena; Chemistry; Kinetics; Organophosphonates; Purines; Retroviridae; Simplexvirus; Structure-Activity Relationship | 1990 |
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Boranes; Boron Compounds; Chlorocebus aethiops; DNA Viruses; HIV-1; Humans; In Vitro Techniques; Nucleosides; Organophosphonates; Phosphates; RNA Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication | 2006 |
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Catalysis; Cell Line; Dose-Response Relationship, Drug; Endogenous Retroviruses; HIV-1; Humans; Kidney; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Stavudine; Swine; Swine, Miniature; Tenofovir; Virus Replication; Zidovudine | 2007 |
Anti-BK virus activity of nucleoside analogs.
Topics: Adenine; BK Virus; Esters; Fatty Acids; Humans; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Virus Replication | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Benzodiazepines; CD4 Antigens; Cytokines; Didanosine; Doxorubicin; Drug Interactions; HIV; HIV Infections; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphocytes; Macrophages; Monocytes; Organ Specificity; Organophosphonates; Zalcitabine; Zidovudine | 1992 |
Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice.
Topics: Adenine; Animals; Antiviral Agents; Embryo, Mammalian; Female; Fetal Resorption; Litter Size; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Mice, Transgenic; Moloney murine leukemia virus; Organophosphonates; Pregnancy; Viremia; Zidovudine | 1991 |
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportunistic Infections; Organophosphonates; Retroviridae; Retroviridae Infections; T-Lymphocytes; Virus Replication; Zidovudine | 1990 |
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Dideoxynucleotides; DNA Polymerase I; DNA Polymerase II; DNA Replication; HeLa Cells; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Thymine Nucleotides; Zidovudine | 1990 |
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus.
Topics: Adenine; Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental; Skull Neoplasms; Zidovudine | 1990 |
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.
Topics: Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HIV-1; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Neoplasm Transplantation; Organophosphonates; Retroviridae; Sarcoma, Experimental; Time Factors; Zidovudine | 1990 |
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV-1; Organophosphonates; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine | 1989 |
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Concanavalin A; Herpes Simplex; Interferons; Mice; Mice, Inbred C57BL; Mitogens; Opportunistic Infections; Organophosphonates; Spleen; Zidovudine | 1989 |
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro.
Topics: Adenine; African Swine Fever Virus; Amides; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Iridoviridae; Organophosphonates; Organophosphorus Compounds; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tubercidin; Vero Cells; Virus Replication; Zidovudine | 1987 |
Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV-1; Humans; Molecular Structure; Organophosphonates; Organophosphorus Compounds; T-Lymphocytes; Zidovudine | 1994 |
Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process.
Topics: Adenine; Antiviral Agents; B-Lymphocytes; Cell Line; Dideoxynucleosides; Dideoxynucleotides; Esters; HIV-1; Humans; Organophosphonates; Oxidoreductases; Prodrugs; T-Lymphocytes; Thymine Nucleotides; Uridine Monophosphate; Zidovudine | 1993 |
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine | 1993 |
MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Didanosine; DNA, Viral; Guanine; HIV Infections; HIV-1; HIV-2; Humans; Male; Mice; Mice, SCID; Monocytes; Organophosphonates; Spleen; T-Lymphocytes; Zidovudine | 1996 |
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
Topics: Adenine; Antiviral Agents; HIV Reverse Transcriptase; HIV-1; Kinetics; Organophosphonates; Phosphates; Rauscher Virus; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zidovudine | 1996 |
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Survival; Clone Cells; Female; Leukemia Virus, Murine; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Organophosphonates; Organophosphorus Compounds; Specific Pathogen-Free Organisms; Spleen; Tenofovir; Virus Replication; Zidovudine | 1998 |
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine | 1998 |
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Topics: Adenine; Anti-HIV Agents; Carrier Proteins; Cell Line; Drug Resistance, Microbial; Gene Amplification; Gene Dosage; Gene Expression; Genes, Dominant; HIV-1; Humans; Hybrid Cells; Inhibitory Concentration 50; Membrane Transport Proteins; Nucleosides; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; RNA, Messenger; T-Lymphocytes; Zidovudine | 1999 |
CDC to revisit AZT, post-exposure guidelines. Centers for Disease Control and Prevention.
Topics: Adenine; Antiviral Agents; Blood-Borne Pathogens; Centers for Disease Control and Prevention, U.S.; Guidelines as Topic; Health Personnel; HIV Infections; Humans; Macaca; Needlestick Injuries; Occupational Exposure; Organophosphonates; Zidovudine | 1996 |
Update on other antivirals.
Topics: Adenine; Antiviral Agents; Didanosine; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Stavudine; Zalcitabine; Zidovudine | 1996 |
Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2001 |
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.
Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; Biological Transport; Catalysis; Cations; Cell Line; Cell Membrane; Chelating Agents; Cobalt; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Fluorides; Humans; Hydrolysis; Insecta; Kinetics; Magnesium; Manganese; Methotrexate; Models, Biological; Multidrug Resistance-Associated Proteins; Nucleotides; Organophosphonates; Protein Binding; Substrate Specificity; Vanadates; Zidovudine | 2004 |
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
Topics: Adenine; Antiviral Agents; Base Sequence; California; Cell Line; Ethnicity; Haplotypes; Humans; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Sequence Alignment; Sequence Analysis, DNA; White People; Zidovudine | 2008 |
Gene induction for the treatment of methylmalonic aciduria.
Topics: Adenine; Cisplatin; Drug Evaluation, Preclinical; Gene Expression Regulation; Green Fluorescent Proteins; HeLa Cells; Humans; Metabolism, Inborn Errors; Methylmalonyl-CoA Mutase; Organophosphonates; RNA, Messenger; Zidovudine | 2009 |
Stop codon read-through of a methylmalonic aciduria mutation.
Topics: Adenine; Chromosomes, Artificial, Bacterial; Cisplatin; Codon, Terminator; Genes, Reporter; Gentamicins; HeLa Cells; Humans; Metabolism, Inborn Errors; Methylmalonyl-CoA Mutase; Mutation, Missense; Organophosphonates; RNA, Messenger; Zidovudine | 2009 |