adefovir has been researched along with tenofovir in 221 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (4.07) | 18.2507 |
| 2000's | 77 (34.84) | 29.6817 |
| 2010's | 126 (57.01) | 24.3611 |
| 2020's | 9 (4.07) | 2.80 |
| Authors | Studies |
|---|---|
| Ballatore, C; Balzarini, J; De Clercq, E; McGuigan, C | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Hocková, D; Holý, A; Masojídková, M; Snoeck, R | 1 |
| Alvarez, K; Balzarini, J; Barral, K; Canard, B; Neyts, J; Priet, S; Sire, J | 1 |
| Baba, M; De Clercq, E; Shi, M; Takao, S; Wang, X | 1 |
| Jiang, JD; Li, YP; Li, ZR; Liu, ZY; Peng, ZG; Tang, YB | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Balzarini, J; Décout, JL; Désiré, J; Gerland, B | 1 |
| Carey, AC; Cihlar, T; Fisher, R; Laflamme, G; Mackman, R; Ray, AS; Vela, JE | 1 |
| Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Agrofoglio, LA; Alexandre, JA; Andrei, G; Azzouzi, A; Balzarini, J; Broggi, J; Caillat, C; Deville-Bonne, D; El-Amri, C; Eriksson, S; Lin, J; Meyer, P; Pradère, U; Roy, V; Snoeck, R; Topalis, D | 1 |
| Balzarini, J; Baszczyňski, O; de Clercq, E; Dračínský, M; Holý, A; Janeba, Z; Jansa, P; Klepetářová, B; Votruba, I | 1 |
| Bao, H; Du, J; Furman, PA; Mosley, RT; Murakami, E; Sofia, MJ | 1 |
| Alvarez, K; Balzarini, J; Barral, K; Canard, B; Durafour, C; Neyts, J; Payrot, N; Priet, S; Roux, L; Weck, C; Zoulim, F | 1 |
| Balzarini, J; Flynn, ÁS; Hinsinger, K; McGuigan, C; Pertusati, F; Powell, N; Tristram, A | 1 |
| El Amri, C; Kaci, M; Lefort, V; Mathé, C; Périgaud, C; Uttaro, JP | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Giesler, KE; Liotta, DC; Marengo, J | 1 |
| Goldmann, S; Li, J; Liu, X; Luo, Z; Ren, Q; Wang, C; Zhang, J; Zhang, Y | 1 |
| Camarasa, MJ; de Castro, S | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Balzarini, J; Casara, P; De Clercq, E; Egberink, H; Hartmann, K; Navé, JF; Pannecouque, C; Vahlenkamp, T; Witvrouw, M | 1 |
| Connelly, MC; Fridland, A; Lee, SH; Pisarev, VM | 1 |
| Cherrington, JM; Mulato, AS | 1 |
| Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I | 1 |
| Baba, M; De Clercq, E; Makino, M; Okada, Y; Suruga, Y; Tanaka, H | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 1 |
| Merigan, TC; Palmer, S; Shafer, RW | 1 |
| Franková, D; Holý, A; Zídek, Z | 1 |
| Gosselin, G; Johnson, RA; Laux, WH; Périgaud, C; Shoshani, I | 1 |
| De Clercq, E; Neyts, J; Ying, C | 1 |
| De Clercq, E; Furman, P; Neyts, J; Nicholson, W; Ying, C | 1 |
| Bischofberger, N; Crabbs, C; Greenhouse, J; Jiang, JB; Lewis, MG; Racz, K; Racz, P; Silvera, P; Yalley-Ogunro, J | 1 |
| Beck, TW; Bischofberger, N; Emau, P; Follis, KE; Morton, WR; Sun, JC; Tran, CA; Tsai, CC | 1 |
| Anton, KE; Cherrington, JM; Fuller, MD; Lamy, PD; Margot, NA; Miller, MD; Mulato, AS | 1 |
| Buckheit, R; Gilbert, H; Margot, N; Miller, M; Palmer, S; Shaw, N | 1 |
| Murono, S; Pagano, JS; Raab-Traub, N | 1 |
| Hitchcock, MJ; Holý, A; Keith, KA; Kern, ER; Lee, WA | 1 |
| De Clercq, E; Frison, E; Helliot, B; Lepoivre, P; Neyts, J; Panis, B; Swennen, R | 1 |
| De Clercq, E | 4 |
| Holý, A; Potmesil, P; Zídek, Z | 1 |
| Crippin, J; Drechsler, H; Lisker-Melman, M; Ristig, M; Tebas, P | 1 |
| Buster, EH; Schalm, SW; van der Eijk, AA | 1 |
| Camino, N; Núñez, M; Puoti, M; Soriano, V | 1 |
| Benhamou, Y | 2 |
| Benhamou, Y; Cahour, A; Katlama, C; Lada, O; Poynard, T; Thibault, V | 1 |
| Berg, T; Bergk, A; Mauss, S; Reinke, P; Schürmann, D; van Bömmel, F; Wiedenmann, B; Wünsche, T | 1 |
| Andrei, G; Balzarini, J; De Clercq, E; Hocková, D; Holý, A; Naesens, L; Pannecouque, C; Snoeck, R | 1 |
| Däumer, M; Kaiser, R; Matz, B; Rockstroh, JK; Schewe, CK; Schildgen, O; Vogel, M; Weitner, L | 1 |
| Benhamou, Y; Bonacini, M; Brook, G; Cargnel, A; Puoti, M; Rockstroh, J; Soriano, V; Thio, C | 1 |
| Bleasby, K; Hall, LA; Mohrenweiser, HW; Perry, JL; Pritchard, JB | 1 |
| Cañas, C; Casais, LA; Casanova, A; Chahri, N; Figueras, J; Gornals, J; Lopez, C; Taltavull, TC; Verdura, B | 1 |
| Berg, T; van Bömmel, F | 2 |
| Gerlich, WH; Hartmann, H; Schildgen, O | 1 |
| Roche, B; Samuel, D | 1 |
| Schiff, ER; Schreibman, IR | 1 |
| Funk, A; Gerlich, WH; Hartmann, H; Helm, M; Olotu, C; Rockstroh, JK; Schildgen, O; Sirma, H; Wend, UC; Will, H; Willems, WR | 1 |
| Delaney, WE; Miller, MD; Qi, X; Ray, AS; Xiong, S; Yang, H; Zhu, Y | 1 |
| Berg, T; Feucht, HH; Hüppe, D; Möller, B; Sarrazin, C; Spengler, U; van Bömmel, F; Wiedenmann, B; Zöllner, B | 1 |
| Grant, RM; Levy, V | 1 |
| Durantel, S; Girard, PM; Gozlan, J; Lacombe, K; Ollivet, A; Tran, N; Zoulim, F | 1 |
| Carriero, D; Dieterich, DT; Jaffe, D; Lucas, J; Park, JS; Santos, SA; Uriel, AJ | 1 |
| Adachi, M; Imaoka, T; Kusuhara, H; Schuetz, JD; Sugiyama, Y; Takeuchi, K | 1 |
| Balzarini, J; De Clercq, E; Hocková, D; Holý, A; Masojidkova, M; Schols, D; Van Laethem, K | 1 |
| Anzenbacher, P; Anzenbacherová, E; Holý, A; Matal, J; Nekvindová, J; Orság, J; Veinlichová, A; Zídek, Z | 1 |
| Anzenbacher, P; Anzenbacherová, E; Holý, A; Masek, V; Nekvindová, J; Veinlichová, A; Zídek, Z | 1 |
| Ida, H; Inui, K; Katsura, T; Tsuji, Y; Uwai, Y | 1 |
| Garcia-Gasco, P; Sheldon, J; Soriano, V | 1 |
| Alvarez, K; Barral, K; Canard, B; Frangeul, A | 1 |
| Daniels, E; Gaglio, PJ; Sterling, R; Tedaldi, E | 1 |
| Colombo, S; Del Poggio, P; Jamoletti, C; Oggionni, M; Puhalo, V; Zaccanelli, M | 1 |
| de Man, RA; Janssen, HL; Leemans, WF; Niesters, HG | 1 |
| Degertekin, B; Husain, M; Lok, AS; Oberhelman, K; Tan, J; Wong, SN | 1 |
| Byun, KS; Choe, WH; Kim, BK; Kim, GH; Ko, SY; Kwon, SY; Lee, CH; Yeon, JE | 1 |
| Alvarez, K; Barral, K; Bussetta, C; Canard, B; Deval, J; Frangeul, A | 1 |
| Mauss, S | 1 |
| Alvarez, K; Barral, K; Canard, B; Deville-Bonne, D; El-Amri, C; Guerreiro, C; Mulard, L; Munier-Lehmann, H; Schneider, B; Topalis, D; Véron, M | 1 |
| Boelle, PY; Bonnard, P; Boyd, A; Girard, PM; Gozlan, J; Lacombe, K; Lascoux-Combe, C; Miailhes, P; Molina, JM; Serfaty, L; Zoulim, F | 1 |
| Deterding, K; Manns, MP; Wedemeyer, H | 1 |
| Canbay, A; Gerken, G; Gerlich, WH; Jochum, C; Katsounas, A; Schlaak, J | 1 |
| Li, B; Patty, A; Seifer, M; Serra, I; Standring, DN | 1 |
| Sarmento E Castro, R; Sheldon, J; Soriano, V | 1 |
| Buster, EH; Janssen, HL; Schalm, SW | 1 |
| Colombo, M; Lampertico, P | 1 |
| Baumert, TF; Doffoel, M; Fafi-Kremer, S; Gut, JP; Habersetzer, F; Pastor, R; Schvoerer, E; Stoll-Keller, F | 1 |
| Lampertico, P | 1 |
| Moreno, V; Valencia, ME | 1 |
| Ham, MY; Holt, C; Saab, S; Stone, MA; Tong, M | 1 |
| Borroto-Esoda, K; Curtis, M; Miller, MD; Qi, X; Zhu, Y | 1 |
| Balzarini, J; De Clercq, E; Koszytkowska-Stawińska, M | 1 |
| Buffet, C | 1 |
| de la Loma, GA; Mateos Lindemann, M; Moreira Vicente, V; Rodríguez Dominguez, M | 1 |
| Brancaccio, G; Gaeta, GB; Nardiello, S; Precone, V; Sgrò, G; Stornaiuolo, G | 1 |
| Barreiro, P; Fernández, JV; Labarga, P; Medrano, J; Soriano, V; Tuma, P; Vispo, E | 1 |
| Berg, T; Böcher, WO; Buggisch, P; de Man, RA; Deterding, K; Erhardt, A; Feucht, HH; Hüppe, D; Möller, B; Petersen, J; Reinders, JG; Rhode, P; Sarrazin, C; Spengler, U; Stein, K; Trojan, J; van Bömmel, F; Wasmuth, HE; Wedemeyer, H; Wiedenmann, B | 1 |
| Funk, A; Helm, M; Olotu, C; Rockstroh, JK; Schildgen, O; Sirma, H; Zöllner, B | 1 |
| Gervain, J; Horváth, G; Hunyady, B; Makara, M; Pár, A; Szalay, F; Telegdy, L; Tornai, I | 1 |
| Lau, GK | 1 |
| Marcellin, P; Piratvisuth, T; Sung, J | 1 |
| Chee, GM; Poordad, F | 1 |
| Colquitt, J; Cooper, K; Harris, P; Jones, J; Shepherd, J | 1 |
| Bao, H; Furman, PA; Korba, B; Micolochick Steuer, HM; Murakami, E; Niu, C; Tolstykh, T | 1 |
| Coffin, CS; Michalak, TI; Mulrooney-Cousins, PM; Peters, MG; Roberts, JP; Terrault, NA; van Marle, G | 1 |
| Chen, EQ; Tang, H | 1 |
| Dakin, H; Fidler, C; Harper, C | 1 |
| Einecke, D | 1 |
| Chotiyaputta, W; Ditah, FA; Goodwin, D; Lok, AS; Peterson, C | 1 |
| Angus, PW; Bowden, S; Desmond, PV; George, J; Lee, AU; Locarnini, S; Nicoll, AJ; Patterson, SJ; Roberts, SK; Sievert, W; Strasser, SI | 1 |
| Benhamou, Y; Pais, R | 1 |
| Marcellin, P | 1 |
| Leung, N | 1 |
| Papatheodoridis, GV | 1 |
| Zoulim, F | 1 |
| Mallet, V; Pol, S; Vallet-Pichard, A | 1 |
| Chen, LZ; Dai, XH; Fan, XG; Tang, LH; Wang, W; Zhao, SS; Zhou, RR | 1 |
| Andersen, ES; Christensen, PB; Frigstad, SO; Kjær, M; Konopski, Z; Krarup, H; Leutscher, P; Moessner, B; Weiland, O; Weis, N; Westin, J | 1 |
| Benetti, S; Cassino, L; Fay, F; Quarleri, J; Tanno, H | 1 |
| Hostetler, KY; Ray, AS | 1 |
| Chan, HL; Chan, HY; Ong, A; Tse, CH; Wong, GL; Wong, VW | 1 |
| Fontana, RJ; Singal, AK | 1 |
| Colson, P; Dupouey, J; Gerolami, R; Solas, C | 1 |
| Gervain, J; Horváth, G; Hunyady, B; Makara, M; Pár, A; Szalay, F; Telegdy, L; Tornai, I; Ujhelyi, E | 1 |
| Chong, WH; Collins, MT; Gara, N; Ghany, MG; Hoofnagle, JH; Jake Liang, T; Kleiner, DE; Zhao, X | 1 |
| Akriviadis, E; Antoniadis, N; Cholongitas, E; Goulis, I; Papanikolaou, V; Vasiliadis, T | 1 |
| Bozdayi, AM; Cevik, E; Idilman, R; Kabaçam, G; Karatayli, E; Karatayli, SC; Seven, G; Yakut, M; Yurdaydin, C | 1 |
| Baak, BC; Bakker, CM; Beuers, UH; Brouwer, JT; Buster, EH; Drenth, JP; Honkoop, P; Janssen, HL; Kerbert-Dreteler, MJ; Koek, GH; Tan, AC; van der Spek, BW; van Erpecum, KJ; van Hoek, B; van Nieuwkerk, KM; van Soest, H; Vrolijk, JM | 1 |
| Bahrami, S; Chevaliez, S; Grare, M; Hézode, C; Pawlotsky, JM | 1 |
| Buti, M; Petersen, J | 1 |
| Baietto, L; Boglione, L; Burdino, E; Cariti, G; Cusato, J; D'Avolio, A; De Rosa, FG; Di Perri, G; Ghisetti, V; Gregori, G | 1 |
| Cui, YJ; Song, ZL; Teng, DH; Zheng, H; Zheng, WP | 1 |
| Acurcio, Fde A; Almeida, AM; Andrade, EI; Araújo de Oliveira, GL; Brandão, CM; Carmo, RA; Cherchiglia, ML; Silva, AL | 1 |
| Brown, RS; Chang, MS; Emond, JC; Guarrera, JV; Heese, S; Olsen, SK; Pichardo, EM; Stiles, JB | 1 |
| Brown, RS; Brubaker, WD; Chang, MS; Emond, JC; Guarrera, JV; Olsen, SK; Pichardo, EM; Rosenthal-Cogan, L; Stiles, JB | 1 |
| Fontana, RJ; Kuo, YF; Salameh, H; Singal, AK | 1 |
| Al Hawajri, N; Borroto-Esoda, K; Dény, P; Kitrinos, K; Lavocat, F; Pichoud, C; Zoulim, F | 1 |
| Goyal, N; Gupta, S; Kumar, A; Taneja, S; Wadhawan, M | 1 |
| Fung, J; Huang, FY; Hung, IF; Lai, CL; Liu, K; Seto, WK; Wong, DK; Yuen, MF | 1 |
| Horváth, G | 1 |
| Flint, OP; Wang, F | 1 |
| Chi, X; Hu, X; Lian, Z; Lv, J; Niu, J; Pan, Y; Sun, H; Tu, Z; Xu, D; Yan, H | 1 |
| Kitrinos, KM; Liu, Y; Miller, MD | 1 |
| Berg, T; Chan, S; Dinh, P; Flaherty, JF; Kitrinos, KM; Manns, M; Marcellin, P; McHutchison, JG; Moeller, B; Trinh, H; Zoulim, F | 1 |
| Cholongitas, E; Papatheodoridis, G; Pipili, C | 1 |
| Acurcio, Fde A; Almeida, AM; Andrade, EI; Brandão, CM; Cherchiglia, ML; Oliveira, GL; Silva, AL | 1 |
| Fung, J; Lai, CL; Seto, WK; Yuen, MF | 1 |
| Buti, M | 1 |
| Colombo, M; Della Corte, C; Triolo, M | 1 |
| Esteban, R; Pérez-Cameo, C; Pons, M | 1 |
| Akyüz, F; Badur, S; Baran, B; Bozdayi, AM; Idilman, R; Kabaçam, G; Karatayli, E; Karatayli, S; Kaymakoglu, S; Keskin, O; Onel, D; Ormeci, AC; Tüzün, A; Yurdaydin, C | 1 |
| Kang, Y; Lin, X; Liu, H; Lu, M; Mao, R; Qin, Y; Wang, J; Zhang, J; Zhang, Y; Zhu, H | 1 |
| Gervain, J; Horváth, G; Hunyady, B; Lengyel, G; Makara, M; Pár, A; Szalay, F; Telegdy, L; Tornai, I | 1 |
| Cainelli, F; Comparcola, D; Della Corte, C; Nobili, V; Vento, S | 1 |
| De Vincentis, A; Dell'Unto, C; Galati, G; Gallo, P; Picardi, A; Solmone, MC; Vespasiani-Gentilucci, U; Vincenti, D | 1 |
| Locarnini, S; Warner, N | 1 |
| Beggel, B; Kaiser, R; Neumann-Fraune, M; Obermeier, M | 1 |
| Afdhal, NH; Bonder, A; Lau, D; Patwardhan, VR; Sengupta, N | 1 |
| Berkhout, B; van Hemert, FJ; Zaaijer, HL | 1 |
| Alcantara, L; Burak, KW; Coffin, CS; Klein, P; Myers, RP; Pang, JX; Rezaeeaval, M | 1 |
| Leach, KL; Piotrowski, M; Wang, R; Zhang, H; Zhang, X | 1 |
| Fan, H; Fan, Y; Ge, Y; Li, D; Liu, X; Liu, Z; Lyu, W; Yang, H; Zhou, B | 1 |
| Andrade, JR; Barros, LM; Bertolini, DA; Carrilho, FJ; Conde, SR; de Araújo, LV; Ferreira, AC; Ferreira, AS; Galvan, J; Gomes-Gouvêa, MS; Kliemann, DA; Kunyoshi, AS; Leite, AG; Lyra, AC; Mendes-Corrêa, MC; Nastri, AC; Oikawa, MK; Piccoli, LZ; Pinho, JR; Rezende, RE; Soares, MC; Teixeira, R | 1 |
| Choudhary, NS; Goja, S; Menon, PB; Mohanka, R; Rastogi, A; Saigal, S; Saraf, N; Soin, AS | 1 |
| Ha, FS; Han, T; Liu, H; Liu, L; Nie, CY; Zhang, Q | 1 |
| Caccuri, F; Caruso, A; Castelli, F; De Francesco, MA; Gargiulo, F; Giagulli, C; Spinetti, A; Zaltron, S | 1 |
| An, J; Byun, KS; Kim, YJ; Kwon, SY; Lee, HC; Lee, YS; Lim, YS; Yoo, BC | 1 |
| Fong, TL; Hsieh, MJ; Khemichian, S; Kim, J; Limurti, J; Zhang, SR | 1 |
| Cheong, JY; Cho, HJ; Cho, SW; Kim, SS; Shin, SJ; Yoo, BM | 1 |
| Bang, SJ; Jeong, ID; Jung, SW; Kim, BG; Kim, CJ; Kim, MH; Lee, BU; Park, BR; Park, JH; Park, NH; Shin, JW | 1 |
| Bang, SJ; Jeong, ID; Jung, SW; Kim, BG; Kim, CJ; Kim, EH; Kim, JH; Kim, MH; Lee, BU; Park, BR; Park, JH; Park, NH; Shin, JW; Sung, SJ | 1 |
| Casazza, G; Colombo, M; de Franchis, R; Facchetti, F; Fraquelli, M; Iavarone, M; Invernizzi, F; Jovani, M; Lampertico, P; Loglio, A; Mangia, G; Primignani, M; Viganò, M | 1 |
| Jansen, L; Kootstra, NA; Reesink, HW; Takkenberg, RB; van Dort, KA; Zaaijer, HL | 1 |
| Ahn, SH; Chong, Y; Kang, HS; Kim, BK; Kim, DH; Kim, KH; Lee, AR; Park, ES; Park, S; Park, YK; Rhee, JK; Shin, GC; Yang, SI | 1 |
| Chu, CK; Konreddy, AK; Rawal, RK | 1 |
| Amani, A; Niederau, C; Thiel, A | 1 |
| Park, JG; Park, SY | 1 |
| Kittitrakul, C; Leowattana, W; Nontprasert, A; Phumratanaprapin, W; Poovorawan, K; Sriboonvorakul, N; Tangkijvanich, P; Thu, AM; Wilairatana, P | 1 |
| Bair, MJ; Chang, CW; Chen, CJ; Chen, MJ; Chu, CH; Hu, KC; Lee, KH; Lin, CC; Lin, SC; Liou, TC; Liu, CY; Shih, SC; Wang, HY; Wang, TE | 1 |
| Cao, Y; Dai, CY; Hou, W; Jiang, B; Li, XM; Lu, W; Su, R; Xu, J | 1 |
| Chen, L; Ding, Y; Wang, D; Xiao, Q; Yang, J; Yang, W | 1 |
| Beraud, G; Chagneau-Derrode, C; Garcia, M; Godet, C; Le Moal, G; Roblot, F | 1 |
| Gao, Y; Ke, W; Liu, L; Yang, Y; Yao, Z; Ye, X; Zhang, C; Zhou, S | 1 |
| Ahn, SH; Choe, WH; Kim, JH; Kim, KH; Ko, SY; Kwon, SY | 1 |
| Akriviadis, E; Antoniadis, N; Cholongitas, E; Fouzas, I; Giakoustidis, D; Giouleme, O; Goulis, I; Imvrios, G; Papanikolaou, V; Vasiliadis, T | 1 |
| Chen, J; Li, M; Xi, H; Xu, X; Zhang, R; Zhang, X; Zhang, Y | 1 |
| Asano, M; Dohi, T; Enomoto, N; Gatanaga, H; Honda, M; Inoue, T; Kaneko, S; Kawamura, YI; Matsumoto, A; Mizokami, M; Murata, K; Nishida, N; Oka, S; Sakamoto, M; Shirasaki, T; Shuno, Y; Sugiyama, M; Tanaka, E; Yano, H | 1 |
| An, J; Du, C; Gao, JL; Jiang, Y; Li, M; Ma, H; Wang, X; Zhang, L | 1 |
| Adinolfi, LE; Andreana, L; Boemio, A; Guerrera, B; Marrone, A; Pasquale, G; Rainone, I; Rinaldi, L; Ruggiero, G; Zampino, R | 1 |
| Angarano, G; Fasano, M; Fiore, JR; Leone, A; Maggi, P; Santantonio, TA; Volpe, A | 1 |
| Lim, YS | 1 |
| Cho, EJ; Cho, Y; Chung, GE; Kim, HY; Kim, YJ; Lee, DH; Lee, JH; Lee, M; Yoo, JJ; Yoon, JH; Yu, SJ; Zoulim, F | 1 |
| Chen, FY; Cheng, Z; Huang, HH; Shi, KQ; Van Poucke, S; Zhang, MY; Zheng, JN; Zheng, MH; Zhu, GQ | 1 |
| Capobianchi, MR; D'Offizi, G; Menzo, S; Piselli, P; Solmone, M; Vincenti, D | 1 |
| He, L; Jiang, Y; Liu, X; Wang, X; Yang, Z; Zhang, S; Zhao, Y | 1 |
| Chen, J; Chen, L; Cheng, L; Chi, W; Deng, H; Huo, Y; Lan, Z; Liu, X; Siegenthaler, JA; Song, W; Sun, K; Xu, L; Zhao, X | 1 |
| Liu, CJ; Su, TH | 1 |
| Hu, C; Huang, H; Li, Y; Liu, J; Yang, D; Yuan, G; Zhang, YY; Zhou, F; Zhou, Y | 1 |
| Beuers, U; de Niet, A; Jansen, L; Koot, M; Kuiken, SD; Molenkamp, R; Reesink, HW; Stelma, F; Takkenberg, RB; van Nieuwkerk, CMJ; Verheij, J; Weijer, S; Willemse, SB; Zaaijer, HL | 1 |
| Kaltashov, IA; Xu, S | 1 |
| Aggeletopoulou, I; Anastassiou, ED; Assimakopoulos, S; Gogos, C; Kalafateli, M; Labropoulou-Karatza, C; Mandellou, M; Taprantzi, D; Thomopoulos, K; Triantos, C; Tselekouni, P; Tsiaoussis, G; Vourli, G | 1 |
| Buti-Ferret, M; Edwards, R; Gaggar, A; Gane, E; Jackson, K; Janssen, H; Kitrinos, K; Littlejohn, M; Locarnini, S; Marcellin, P; Revill, P; Subramanian, M; Thompson, A; Wong, D | 1 |
| Caviglia, GP; Ngatchou, D; Olivero, A; Saracco, GM; Smedile, A | 1 |
| Ahmed, A; Kim, D; Kim, WR; Udompap, P | 1 |
| Naing, C; Poovorawan, Y; Tong, KS | 1 |
| Hiraoka, A; Izumoto, H; Kitahata, S; Kondoh, K; Michitaka, K; Ninomiya, T; Tsubouchi, E; Ueki, H; Yamago, H | 1 |
| Chang, Y; Cho, EJ; Cho, H; Cho, YY; Kim, YJ; Lee, JH; Nam, JY; Yoon, JH; Yu, SJ | 1 |
| Lopatin, U | 1 |
| Cloherty, G; Deerain, J; Gaggar, A; Hammond, R; Kitrinos, K; Leary, T; Locarnini, S; O'Donnell, T; Subramanian, M; Walsh, R; Wong, D; Yuen, L | 1 |
| Chen, H; Ding, Y; Jin, W; Li, C; Li, X; Liu, C; Liu, J; Niu, J; Wu, M; Zhang, D; Zhang, H; Zhu, X | 1 |
| Babudieri, S; Bagella, P; Bandiera, F; Calvisi, DF; Fiore, V; Garrucciu, G; Madeddu, G; Mannu, F; Melis, M; Muredda, AA; Ortu, S; Zaru, S | 1 |
| Ahn, SH; Bae, SH; Heo, J; Jang, JY; Kim, CW; Kim, DJ; Kim, IH; Park, JY; Tak, WY; Woo, HY | 1 |
| Jang, BK | 1 |
| Enomoto, M; Kawada, N; Nishiguchi, S; Tamori, A; Yoshida, K | 1 |
| Chen, R; Li, J; Li, L; Li, X; Liu, LM; Liu, Y; Shao, J; Xu, D; Zhao, L; Zhou, Y | 1 |
| Arai, K; Hayakawa, N; Honda, M; Horii, R; Kagaya, T; Kaneko, S; Kawaguchi, K; Komura, T; Mizukoshi, E; Nio, K; Nishikawa, M; Orita, N; Sakai, Y; Shimakami, T; Shimode, T; Takatori, H; Terashima, T; Yamashita, T | 1 |
45 review(s) available for adefovir and tenofovir
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?
Topics: Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Therapy, Combination; HIV; Humans; Microbial Sensitivity Tests; Molecular Structure; Polypharmacology | 2018 |
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Cidofovir; Cytosine; DNA Virus Infections; DNA Viruses; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Infectious Disease Transmission, Professional-to-Patient; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Physicians; Risk Factors; Risk Management; Tenofovir; Viral Load | 2003 |
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel.
Topics: Adenine; Antiviral Agents; Comorbidity; Deoxycytidine; Disease Progression; Drug Monitoring; Emtricitabine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Tenofovir | 2005 |
[Liver transplantation for complications of hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Vaccination; Viral Load; Virus Replication | 2006 |
Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Nucleotides; Organophosphonates; Recurrence; Tenofovir | 2006 |
Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Guanine; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Preventive Medicine; Tenofovir | 2006 |
[Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients].
Topics: Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2006 |
Treatment of chronic hepatitis B in HIV-infected patients in 2007.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2007 |
Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2007 |
The discovery of antiviral agents: ten different compounds, ten different stories.
Topics: Acyclovir; Adenine; Antiviral Agents; Benzodiazepines; Benzylamines; Cidofovir; Cyclams; Cytosine; Heterocyclic Compounds; Humans; Imidazoles; Nucleosides; Organophosphonates; Tenofovir; Valacyclovir; Valine; Virus Diseases | 2008 |
[Resistance in hepatitis B virus].
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Gene Products, pol; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Models, Molecular; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Virus Replication | 2008 |
Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Pyrimidinones; Randomized Controlled Trials as Topic; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2008 |
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2009 |
[Chronic hepatitis B: current therapy].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Immunotherapy, Active; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome | 2008 |
Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion.
Topics: Adenine; Adjuvants, Immunologic; Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Randomized Controlled Trials as Topic; Risk Assessment; Serologic Tests; Severity of Illness Index; Tenofovir; Treatment Outcome | 2010 |
Avoiding and managing lamivudine resistance in chronic hepatitis B: current approaches and potential strategies including pegylated interferon.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B infection.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Cost-Benefit Analysis; Disease Progression; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Models, Economic; Organophosphonates; Quality of Life; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; United Kingdom | 2010 |
Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2010 |
Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2011 |
Hepatitis B virus resistance to antiviral drugs: where are we going?
Topics: Adenine; Antiviral Agents; Capsid; Clinical Protocols; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Virus Internalization; Virus Replication | 2011 |
The impact of human immunodeficiency virus on viral hepatitis.
Topics: Adenine; Antiviral Agents; Deoxycytidine; Disease Progression; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B; Hepatitis C; Hepatitis Viruses; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review.
Topics: Adenine; Antiviral Agents; Controlled Clinical Trials as Topic; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
Application of kinase bypass strategies to nucleoside antivirals.
Topics: Adenine; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytosine; History, 20th Century; History, 21st Century; Humans; Nucleosides; Nucleotides; Organophosphonates; Phosphotransferases; Tenofovir | 2011 |
Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome; Viral Load | 2012 |
Considerations for the long-term treatment of chronic hepatitis B with nucleos(t)ide analogs.
Topics: Adenine; Age Factors; Antiviral Agents; Comorbidity; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Life Style; Organophosphonates; Severity of Illness Index; Telbivudine; Tenofovir; Thymidine; Time Factors | 2012 |
Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Mutation; Nucleosides; Nucleotides; Organophosphonates; Prognosis; Tenofovir; Viral Load | 2012 |
Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B.
Topics: Adenine; Administration, Oral; Age Factors; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Incidence; Liver Neoplasms; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2013 |
[Interdisciplinary aspects of and new drugs for chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Comorbidity; Drug Interactions; Drug Therapy, Combination; Female; Gastroenterology; Guanine; Hematology; Hepatitis B, Chronic; Humans; Hungary; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease Transmission, Vertical; Interdisciplinary Communication; Interferons; Lamivudine; Medical Oncology; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Rheumatology; Tenofovir | 2013 |
The Holý Trinity: the acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Humans; Nucleosides; Organophosphonates; Prodrugs; Tenofovir; Virus Diseases | 2013 |
Review article: nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Renal Insufficiency, Chronic; Telbivudine; Tenofovir; Thymidine | 2014 |
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Organophosphonates; Pharmacovigilance; Pregnancy; Telbivudine; Tenofovir; Thymidine | 2014 |
HBeAg-positive chronic hepatitis B: why do i treat my patients with Nucleos(t)ide analogs?
Topics: Adenine; Age Factors; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Precision Medicine; Recombinant Proteins; Sex Factors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2014 |
Impact of HBV therapy on the incidence of hepatocellular carcinoma.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Tenofovir | 2014 |
New therapeutic perspectives in HBV: when to stop NAs.
Topics: Adenine; Algorithms; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine | 2014 |
Management of chronic hepatitis B in children: an unresolved issue.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Carrier State; Child; Databases, Bibliographic; Guanine; Hepatitis B, Chronic; Humans; Immune Tolerance; Incidence; Interferons; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Risk; Tenofovir | 2014 |
Management of Antiviral Resistance in Chronic Hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Tenofovir | 2017 |
Nucleos(t)ide analogues for preventing HBV reactivation in immunosuppressed patients with hematological malignancies: a network meta-analysis.
Topics: Adenine; Antiviral Agents; Controlled Clinical Trials as Topic; Guanine; Hematologic Neoplasms; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Lamivudine; Organophosphonates; Survival Analysis; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Activation | 2017 |
Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Retrospective Studies; Survival Analysis; Telbivudine; Tenofovir; Thymidine | 2017 |
Combination Therapy for Chronic Hepatitis B: Current Updates and Perspectives.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Viral Load | 2017 |
Comparative effectiveness of anti-viral drugs with dual activity for treating hepatitis B and HIV co-infected patients: a network meta-analysis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Coinfection; Emtricitabine; Female; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Network Meta-Analysis; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2018 |
Drugs in the Pipeline for HBV.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Forecasting; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Assessment; Tenofovir; Treatment Outcome; Virus Replication | 2019 |
Combination of Entecavir or Tenofovir with Pegylated Interferon-α for Long-Term Reduction in Hepatitis B Surface Antigen Levels: Simultaneous, Sequential, or Add-on Combination Therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Reproducibility of Results; Tenofovir; Treatment Outcome; Viral Load | 2021 |
20 trial(s) available for adefovir and tenofovir
| Article | Year |
|---|---|
Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408.
Topics: Adenine; Anti-HIV Agents; Double-Blind Method; Genes, Viral; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir | 2001 |
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection.
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Hepatitis B, Chronic; HIV Infections; Humans; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2006 |
Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viremia | 2007 |
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations.
Topics: Adenine; Adult; Aged; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Viral Load | 2008 |
Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Tenofovir; Treatment Outcome; Viral Load | 2008 |
Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Aged, 80 and over; DNA, Viral; Drug Resistance, Viral; Epidemiologic Methods; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load; Young Adult | 2011 |
Clonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genome, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2013 |
Similar evolution of hepatitis B virus quasispecies in patients with incomplete adefovir response receiving tenofovir/emtricitabine combination or tenofovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Evolution, Molecular; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phylogeny; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Treatment Failure; Young Adult | 2013 |
Antiviral treatment improves disrupted peripheral B lymphocyte homeostasis in chronic hepatitis B virus-infected patients.
Topics: Adenine; Adult; Antiviral Agents; B-Lymphocytes; Female; Flow Cytometry; Hepatitis B, Chronic; Homeostasis; Humans; Liver Diseases; Male; Organophosphonates; Tenofovir; Viral Load; Virus Replication | 2013 |
Long-term efficacy and safety of emtricitabine plus tenofovir DF vs. tenofovir DF monotherapy in adefovir-experienced chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome; Viral Load; Viremia | 2014 |
Tenofovir monotherapy versus tenofovir and entecavir combination therapy in adefovir-resistant chronic hepatitis B patients with multiple drug failure: results of a randomised trial.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Republic of Korea; Tenofovir; Treatment Outcome | 2016 |
Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues.
Topics: Adenine; Adult; Amantadine; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reproducibility of Results; RNA, Viral; Tenofovir; Virion | 2016 |
Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial.
Topics: Adenine; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2016 |
Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Intention to Treat Analysis; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Tenofovir; Viral Load; Young Adult | 2017 |
ALT flares during nucleotide analogue therapy are associated with HBsAg loss in genotype A HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir; Young Adult | 2018 |
Predicting HBsAg clearance in genotype A chronic hepatitis B using HBsAg epitope profiling: A biomarker for functional cure.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Double-Blind Method; Epitope Mapping; Epitopes; Female; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Seroconversion; Tenofovir; Viral Load | 2019 |
Safety, efficacy, and pharmacokinetics of pradefovir for the treatment of chronic hepatitis B infection.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tenofovir; Treatment Outcome; Viral Load | 2020 |
Mitochondrial toxicity and body shape changes during nucleos(t)ide analogues administration in patients with chronic hepatitis B.
Topics: Adenine; Adiposity; Antiviral Agents; Cross-Sectional Studies; DNA, Mitochondrial; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Mitochondria; Organophosphonates; RNA, Mitochondrial; Tenofovir | 2020 |
Entecavir+tenofovir vs. lamivudine/telbivudine+adefovir in chronic hepatitis B patients with prior suboptimal response.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Sustained Virologic Response; Telbivudine; Tenofovir | 2020 |
156 other study(ies) available for adefovir and tenofovir
| Article | Year |
|---|---|
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
Topics: Adenine; Alanine; Amides; Antiviral Agents; Drug Stability; Esterases; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphoric Acids; Prodrugs; Retroviridae; Structure-Activity Relationship; Tenofovir | 2001 |
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activity.
Topics: Anti-HIV Agents; Antineoplastic Agents; Antiviral Agents; Cell Line; DNA Viruses; Humans; Nucleosides; Organophosphonates; Pyrimidines; Retroviridae; Structure-Activity Relationship | 2003 |
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Boranes; Boron Compounds; Chlorocebus aethiops; DNA Viruses; HIV-1; Humans; In Vitro Techniques; Nucleosides; Organophosphonates; Phosphates; RNA Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication | 2006 |
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Catalysis; Cell Line; Dose-Response Relationship, Drug; Endogenous Retroviruses; HIV-1; Humans; Kidney; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Stavudine; Swine; Swine, Miniature; Tenofovir; Virus Replication; Zidovudine | 2007 |
Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro.
Topics: Antiviral Agents; Cells, Cultured; Drug Design; Esters; Hepatitis B virus; HIV-1; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Nucleotides; Prodrugs | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Anti-retroviral and cytostatic activity of 2',3'-dideoxyribonucleoside 3'-disulfides.
Topics: Anti-HIV Agents; Anti-Retroviral Agents; Cell Line; Cell Survival; Dideoxynucleosides; Disulfides; Humans; Phosphorylation; Structure-Activity Relationship; Thymidine Kinase | 2008 |
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.
Topics: Antiviral Agents; Catalytic Domain; Cells, Cultured; Crystallography, X-Ray; Herpesviridae; Humans; Ligands; Models, Molecular; Molecular Structure; Nucleoside-Phosphate Kinase; Organophosphonates; Prodrugs; Pyrimidine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase | 2011 |
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Topics: 2-Aminopurine; 3T3 Cells; Adenine; Animals; Antiviral Agents; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HIV-1; HIV-2; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Organophosphonates; Purines; Structure-Activity Relationship | 2011 |
Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.
Topics: 2-Aminopurine; Adenosine Monophosphate; Amino Acid Sequence; Aminohydrolases; Biocatalysis; Cell Line, Tumor; Cloning, Molecular; Electrophoresis, Polyacrylamide Gel; Humans; Hydrolysis; Isoenzymes; Kinetics; Molecular Sequence Data; Molecular Structure; Molecular Weight; Nucleoside Deaminases; Phosphorylation; Purines; Recombinant Proteins; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Zinc | 2011 |
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.
Topics: Antiviral Agents; Cell Line; Chromatography, High Pressure Liquid; Drug Stability; Hepatitis B virus; HIV-1; Humans; Magnetic Resonance Spectroscopy; Organophosphonates; Spectrometry, Mass, Fast Atom Bombardment; Virus Replication | 2011 |
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Papillomavirus Infections; Prodrugs; Structure-Activity Relationship; Tenofovir; Tumor Cells, Cultured | 2014 |
Synthesis of {[5-(adenin-9-yl)-2-furyl]methoxy}methyl phosphonic acid and evaluations against human adenylate kinases.
Topics: Adenine; Adenylate Kinase; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Organophosphonates; Structure-Activity Relationship | 2014 |
Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatitis B virus; HIV-1; Humans; Leukocytes, Mononuclear; Lipids; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Tenofovir | 2016 |
Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4).
Topics: Administration, Oral; Animals; Antiviral Agents; Capsid; Crystallography, X-Ray; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Viral; Hep G2 Cells; Hepatitis B virus; Humans; Models, Molecular; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2017 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NM
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Fibroblasts; Guanine; Humans; Mice; Mice, Inbred C3H; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Sarcoma Viruses, Murine; Tenofovir | 1997 |
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
Topics: Adenine; Antineoplastic Agents; Cell Line; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Simian virus 40; Tenofovir | 1997 |
Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses.
Topics: Adenine; Anti-HIV Agents; Drug Interactions; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Cells, Cultured | 1997 |
Genotoxicity of purine acyclic nucleotide analogs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine | 1997 |
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Survival; Clone Cells; Female; Leukemia Virus, Murine; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Organophosphonates; Organophosphorus Compounds; Specific Pathogen-Free Organisms; Spleen; Tenofovir; Virus Replication; Zidovudine | 1998 |
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.
Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Neoplasm; Antigens, Surface; Antiviral Agents; Cell Differentiation; Cell Survival; Choriocarcinoma; Drug Therapy, Combination; Enzyme Induction; Growth Inhibitors; Kidney Neoplasms; Methotrexate; Organophosphonates; Organophosphorus Compounds; Progesterone; Rats; Rats, Inbred Strains; Rats, Wistar; Retroviridae; Tenofovir; Trophoblasts; Tumor Cells, Cultured | 1998 |
Hydroxyurea enhances the activities of didanosine, 9-[2-(phosphonylmethoxy)ethyl]adenine, and 9-[2-(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates.
Topics: Adenine; Anti-HIV Agents; Antineoplastic Agents; Didanosine; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Inhibitory Concentration 50; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 1999 |
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL5; Female; Fibrosis; Macrophages, Peritoneal; Nitric Oxide; Organ Size; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Inbred Lew; Spleen; Tenofovir | 1999 |
Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Antiviral Agents; Brain; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Kinetics; Organophosphonates; Rats; Tenofovir | 1999 |
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture.
Topics: Acyclovir; Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Guanine; Hepatitis B virus; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Cells, Cultured | 2000 |
Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Dioxolanes; DNA-Directed DNA Polymerase; DNA, Viral; Guanine; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Purine Nucleosides; Tenofovir; Virus Replication | 2000 |
Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; Antiviral Agents; Lymph Nodes; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load | 2000 |
Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection.
Topics: Adenine; Animals; Disease Models, Animal; DNA, Viral; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2000 |
Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2001 |
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Division; Cidofovir; Cytosine; Epithelial Cells; Growth Inhibitors; Herpesvirus 4, Human; Humans; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Xenograft Model Antitumor Assays | 2001 |
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Poxviridae Infections; Prodrugs; Skin; Tenofovir; Virus Replication | 2003 |
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
Topics: Adenine; Antiviral Agents; Badnavirus; Musa; Organophosphonates; Organophosphorus Compounds; Plant Diseases; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2003 |
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Inhibitory Concentration 50; Interleukin-10; Interleukin-2; Lymphocytes; Mice; Mice, Inbred C57BL; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Tenofovir | 2003 |
Management of chronic hepatitis B in an HIV-positive patient with 3TC-resistant hepatitis B virus.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Forecasting; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Antiretroviral therapy and HIV/hepatitis B virus coinfection.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Cell Line; DNA-Directed DNA Polymerase; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Transfection; Virus Replication | 2004 |
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antiviral Agents; Hepadnaviridae; Herpesviridae; Mice; Models, Chemical; Moloney murine sarcoma virus; Nucleosides; Organophosphonates; Poxviridae; Pyrimidine Nucleosides; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Chronic Disease; DNA-Directed DNA Polymerase; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2004 |
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA; Genetic Variation; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transport Protein 1; Organophosphonates; p-Aminohippuric Acid; Polymorphism, Single Nucleotide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Complementary; Tenofovir; Xenopus laevis | 2005 |
Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Waiting Lists | 2005 |
Reactivation of viral replication after replacement of tenofovir by adefovir.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure; Treatment Outcome; Virus Activation | 2005 |
Replacement of tenofovir with adefovir may result in reactivation of hepatitis B virus replication.
Topics: Adenine; Antiviral Agents; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2006 |
Variant of hepatitis B virus with primary resistance to adefovir.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Viremia | 2006 |
Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus.
Topics: Adenine; Antiviral Agents; Cell Line; Cells, Cultured; Drug Resistance, Viral; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Phosphorylation; Tenofovir | 2006 |
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.
Topics: Adenine; Adult; Disease Progression; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Gene Products, pol; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Virus Replication | 2006 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses | 2007 |
A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient.
Topics: Adenine; Adult; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.
Topics: Adenine; Adenosine Triphosphate; Animals; Antiviral Agents; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Kidney; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Osmosis; Renal Insufficiency; Tenofovir; Tissue Distribution | 2007 |
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mice; Moloney murine sarcoma virus; Organophosphonates; Pyrimidines; Retroviridae Infections; Sarcoma, Experimental; Structure-Activity Relationship; Tenofovir; Tumor Virus Infections | 2007 |
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Topics: Adenine; Bacteria; Cell Membrane; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Liver; Metabolic Detoxication, Phase I; Models, Biological; NADPH-Ferrihemoprotein Reductase; Organophosphonates; Oxygenases; Research Design; Tenofovir; Transformation, Bacterial | 2006 |
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Organophosphonates; Prodrugs; Tenofovir | 2006 |
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Humans; Kidney; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Probenecid; Tenofovir; Transfection | 2007 |
In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.
Topics: Adenine; Adenosine Triphosphate; Boron Compounds; Catalysis; DNA-Directed RNA Polymerases; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Organophosphonates; Plasmids; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Female; Guideline Adherence; Health Care Surveys; Hepatitis B Vaccines; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tenofovir; United States | 2007 |
Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Viral Load; Virus Replication | 2008 |
Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2008 |
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.
Topics: Adenine; Anti-HIV Agents; Binding Sites; Cidofovir; Cytosine; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Organophosphonates; Protein Conformation; Tenofovir | 2008 |
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
Topics: Adenine; Adenosine Triphosphate; Adenylate Kinase; Binding Sites; Boranes; Catalytic Domain; Cloning, Molecular; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Models, Molecular; Nucleotides; Organophosphonates; Phosphorylation; Recombinant Proteins; Tenofovir | 2008 |
[Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients].
Topics: Adenine; Antiviral Agents; Drug Approval; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy?
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Genetic Variation; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2008 |
Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient.
Topics: Adenine; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; Tenofovir | 2008 |
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2009 |
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Genetic Variation; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Proteins | 2009 |
Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2009 |
[Atazanavir-induced nephrolithiasis].
Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Lopinavir; Male; Nephrolithiasis; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Tenofovir | 2009 |
Decision analysis model for hepatitis B prophylaxis one year after liver transplantation.
Topics: Adenine; Administration, Oral; Antiviral Agents; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Health Care Costs; Hepatitis B, Chronic; Humans; Immunoglobulins; Injections, Intramuscular; Lamivudine; Liver Transplantation; Markov Chains; Models, Economic; Organophosphonates; Retrospective Studies; Salvage Therapy; Secondary Prevention; Tenofovir; Time Factors; Treatment Failure; Treatment Outcome | 2009 |
Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues.
Topics: Adenine; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2009 |
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.
Topics: Acids, Acyclic; Adenine; Antiviral Agents; Aza Compounds; Cidofovir; Cytosine; DNA Viruses; HeLa Cells; Humans; Molecular Structure; Nucleosides; Organophosphonates; RNA Viruses; Tenofovir | 2009 |
[Failure to treat hepatitis B virus infection with adefovir due to early selection of rtA181T mutation].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B Antigens; Hepatitis B virus; Humans; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Tenofovir; Time Factors; Treatment Failure | 2010 |
Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Viremia | 2009 |
Hepatitis B in HIV patients: what is the current treatment and what are the challenges?
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Transaminases | 2009 |
Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Adolescent; Adult; Cohort Studies; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2010 |
Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy.
Topics: Adenine; Adult; Amino Acid Sequence; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Selection, Genetic; Sequence Alignment; Tenofovir; Treatment Failure; Viremia; Young Adult | 2010 |
[Protocol for the antiviral therapy of hepatitis B and D].
Topics: Adenine; Antiviral Agents; Biopsy; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis D; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver Cirrhosis; Nucleotides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Viral resistance in hepatitis B: prevalence and management.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genetic Testing; Genotype; Guanine; Hepatitis B; Humans; Lamivudine; Nucleosides; Organophosphonates; Phenotype; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2010 |
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cells, Cultured; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Microbial Sensitivity Tests; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2010 |
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Asian People; DNA, Circular; DNA, Viral; Drug Resistance; Female; Gene Products, pol; Genetic Variation; Genome, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver; Liver Transplantation; Male; Middle Aged; Organophosphonates; Phylogeny; Tenofovir; Trans-Activators; Viral Envelope Proteins; Viral Regulatory and Accessory Proteins; Virus Replication | 2011 |
The curative efficiency of tenofovir for patients with chronic hepatitis B after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Remission Induction; Tenofovir; Treatment Failure | 2010 |
[Treatment of chronic hepatitis B. High response rate in general practice].
Topics: Adenine; Antiviral Agents; Cross-Sectional Studies; Germany; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Long-Term Care; Organophosphonates; Patient Care Team; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2010 |
Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Young Adult | 2011 |
[Long-term therapy for chronic hepatitis B in HIV co-infected patients].
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine | 2010 |
[Treatment has a positive impact on the long-term evolution of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Clinical Trials as Topic; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome | 2011 |
Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs.
Topics: Adenine; Adult; Elasticity Imaging Techniques; Female; Hepatitis B; Humans; Lamivudine; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2011 |
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Middle Aged; Mutation; Organophosphonates; Tenofovir; Treatment Failure | 2011 |
Management options for lamivudine-resistant chronic hepatitis B patients with suboptimal virological suppression by adefovir.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2011 |
Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy.
Topics: Adenine; Adult; Amino Acid Substitution; Hepatitis B virus; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir | 2012 |
[Hungarian consensus guideline for the diagnosis and treatment of B, C, and D viral hepatitis].
Topics: Adenine; Antiviral Agents; Comorbidity; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Guanine; Hepacivirus; Hepatitis B; Hepatitis C; Hepatitis D; Humans; Hungary; Interferon-alpha; Interferons; Lamivudine; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Tubules; Male; Middle Aged; Organophosphonates; Phosphates; Renal Insufficiency; Tenofovir; Time Factors; Uric Acid | 2012 |
Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Nucleotides; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome; Young Adult | 2012 |
The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Drug Approval; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Milk, Human; Netherlands; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pregnancy; Pregnancy Complications, Infectious; Renal Insufficiency; Telbivudine; Tenofovir; Thymidine | 2012 |
Long-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: finite treatment duration unlikely.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Longitudinal Studies; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2013 |
Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D.
Topics: Adenine; Aged; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2013 |
[Cost-effectiveness of nucleoside/nucleotide analogues in chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Markov Chains; Models, Theoretical; Organophosphonates; Quality-Adjusted Life Years; Tenofovir | 2012 |
Prevention of de novo hepatitis B with adefovir plus vaccination in recipients of liver transplants from core antibody-positive donors.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Deoxycytidine; DNA, Viral; Drug Substitution; Emtricitabine; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Liver Transplantation; Middle Aged; Organophosphonates; Tenofovir; Time Factors; Tissue Donors; Treatment Outcome | 2013 |
Prevention of de novo hepatitis B in recipients of core antibody-positive livers with lamivudine and other nucleos(t)ides: a 12-year experience.
Topics: Adenine; Adult; Aged; Analysis of Variance; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Donor Selection; Female; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Logistic Models; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Tenofovir; Time Factors; Tissue Donors; Treatment Outcome; Viral Load | 2013 |
Living related liver transplantation for hepatitis B-related liver disease without hepatitis B immune globulin prophylaxis.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Immunosuppression Therapy; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir; Treatment Outcome | 2013 |
Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment.
Topics: Adenine; Adult; Aged; Antiviral Agents; Asian People; DNA, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hong Kong; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Young Adult | 2013 |
BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue.
Topics: Adenine; Adipocytes; DNA Fragmentation; DNA, Mitochondrial; Epithelial Cells; Humans; Kidney Tubules, Proximal; Mitochondria; Muscle Fibers, Skeletal; Organophosphonates; Primary Cell Culture; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Tenofovir; Thymidine | 2013 |
HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D.
Topics: Adenine; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2014 |
Incorporated antivirals for chronic hepatitis B in Brazil: a cost-effectiveness analysis.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; Brazil; Cost-Benefit Analysis; Disease Progression; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Organophosphonates; Tenofovir; Treatment Outcome | 2013 |
Efficacy of tenofovir in adefovir-experienced patients compared with treatment-naive patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2014 |
Generation of a human hepatoma cell line supporting efficient replication of a lamivudine resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hep G2 Cells; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Organophosphonates; Tenofovir; Virus Replication | 2014 |
[Diagnosis and treatment of chronic hepatitis B and D. Hungarian national consensus guideline].
Topics: Adenine; Antiviral Agents; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Hungary; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2014 |
Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Recombinant Proteins; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load | 2014 |
Antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2014 |
Mechanisms of hepatitis B virus resistance development.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Deoxycytidine; Drug Resistance, Multiple, Viral; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2014 |
Hepatitis B virus drug resistance tools: one sequence, two predictions.
Topics: Adenine; Antiviral Agents; Base Sequence; Drug Resistance, Multiple, Viral; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Evasion; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Telbivudine; Tenofovir; Thymidine | 2014 |
Treatment cessation in noncirrhotic, e-antigen negative chronic hepatitis B is safe and effective following prolonged anti-viral suppression with nucleosides/nucleotides.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Recurrence; Tenofovir; Withholding Treatment; Young Adult | 2014 |
Differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virus.
Topics: Adenine; Adenosine Triphosphate; Binding Sites; Cluster Analysis; Crystallography, X-Ray; Deoxyguanine Nucleotides; Drug Resistance, Viral; Hepatitis B virus; Ligands; Models, Molecular; Mutation; Nucleotides; Open Reading Frames; Organophosphonates; Protein Binding; RNA-Directed DNA Polymerase; Tenofovir; Thermodynamics | 2014 |
The incidence of hepatocellular carcinoma is reduced in patients with chronic hepatitis B on long-term nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Antiviral Agents; Canada; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Nucleosides; Organophosphonates; Retrospective Studies; Risk Factors; Telbivudine; Tenofovir; Thymidine | 2014 |
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Organic Anion Transport Protein 1; Organophosphonates; Tenofovir; Toxicity Tests | 2015 |
[Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Treatment Outcome | 2014 |
HBV carrying drug-resistance mutations in chronically infected treatment-naive patients.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Brazil; DNA, Viral; Drug Resistance, Viral; Gene Products, pol; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation; Organophosphonates; Retrospective Studies; Sequence Analysis, DNA; Tenofovir; Virus Replication | 2015 |
Low-dose short-term hepatitis B immunoglobulin with high genetic barrier antivirals: the ideal post-transplant hepatitis B virus prophylaxis?
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir | 2015 |
Tenofovir rescue regimen following prior suboptimal response to entecavir and adefovir combination therapy in chronic hepatitis B patients exposed to multiple treatment failures.
Topics: Adenine; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; ROC Curve; Tenofovir; Treatment Failure; Treatment Outcome | 2015 |
Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load; Viral Matrix Proteins; Young Adult | 2015 |
Nucleoside-Nucleotide Analog Combination Therapy Is Effective in Preventing Recurrent Hepatitis B After Liver Transplantation.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir | 2015 |
Tenofovir-based rescue therapy in chronic hepatitis B patients with suboptimal responses to adefovir with prior lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Tenofovir; Time Factors; Young Adult | 2015 |
Efficacy of Tenofovir-based Rescue Therapy in Lamivudine-resistant Chronic Hepatitis B Patients With Failure of Lamivudine and Adefovir Combination.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retreatment; Tenofovir; Time Factors; Treatment Outcome | 2015 |
Tenofovir-based rescue therapy for chronic hepatitis B patients who had failed treatment with lamivudine, adefovir, and entecavir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir; Treatment Failure | 2015 |
The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Follow-Up Studies; Forecasting; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Italy; Lamivudine; Liver; Liver Cirrhosis; Male; Middle Aged; Nucleosides; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Survival Rate; Tenofovir | 2015 |
Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Models, Molecular; Organophosphonates; Tenofovir; Virus Replication | 2015 |
Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance.
Topics: Adenine; Adenosine; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Databases, Protein; Drug Resistance, Viral; Gene Products, pol; Guanine; Hepatitis B; Hepatitis B virus; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Organophosphonates; Sequence Alignment; Tenofovir | 2015 |
Long-term follow-up of HBsAg-positive patients in Germany.
Topics: Adenine; Adult; Age Factors; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Germany; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Mass Screening; Middle Aged; Organophosphonates; Prognosis; Prospective Studies; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Time Factors; Turkey | 2016 |
Entecavir plus tenofovir versus entecavir plus adefovir in chronic hepatitis B patients with a suboptimal response to lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Odds Ratio; Organophosphonates; Real-Time Polymerase Chain Reaction; Retrospective Studies; Tenofovir; Viral Load | 2015 |
Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Hospitals; Humans; Incidence; Kidney Diseases; Lamivudine; Male; Middle Aged; Nephrons; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Telbivudine; Tenofovir; Thailand; Thymidine; Tropical Medicine | 2015 |
Off-treatment efficacy of 3-year nucleos(t)ide analogues in chronic hepatitis B patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2016 |
[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; Telbivudine; Tenofovir; Thymidine | 2016 |
First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome.
Topics: Absorptiometry, Photon; Adenine; Alanine; Coinfection; Dose-Response Relationship, Drug; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2016 |
Cost-effectiveness analysis of tenofovir disoproxil fumarate for treatment of chronic hepatitis B in China.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Markov Chains; Organophosphonates; Quality-Adjusted Life Years; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2016 |
The efficacy of tenofovir-based therapy in patients showing suboptimal response to entecavir-adefovir combination therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Republic of Korea; Retrospective Studies; Tenofovir; Treatment Outcome | 2016 |
Nucleos(t)ide analog(s) prophylaxis after hepatitis B immunoglobulin withdrawal against hepatitis B and D recurrence after liver transplantation.
Topics: Adenine; Adult; Antiviral Agents; Coinfection; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome; Withholding Treatment; Young Adult | 2016 |
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2016 |
Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asymptomatic Infections; Carcinoma, Hepatocellular; Culture Media, Conditioned; DNA, Viral; Female; Gene Expression; Genotype; Guanine; Hep G2 Cells; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HT29 Cells; Humans; Interferons; Interleukins; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Polymorphism, Genetic; Recombinant Proteins; Tenofovir; Up-Regulation; Young Adult | 2018 |
A novel pretreatment method combining sealing technique with direct injection technique applied for improving biosafety.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Humans; Limit of Detection; Organophosphonates; Tenofovir; Ultrafiltration; Virus Diseases | 2017 |
Tenofovir disoproxil fumarate monotherapy maintains HBV suppression achieved by a "de novo" combination of lamivudine-adefovir: a pilot study.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Italy; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Tenofovir; Treatment Outcome; Viral Load | 2016 |
Long-term efficacy and safety of switching from lamivudine+adefovir to tenofovir disoproxil fumarate in virologically suppressed patients.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Italy; Kaplan-Meier Estimate; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2017 |
Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naïve patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Nucleotides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Tenofovir; Treatment Outcome | 2017 |
Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment.
Topics: Adenine; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Evolution, Molecular; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymorphism, Genetic; RNA-Directed DNA Polymerase; Sequence Analysis; Tenofovir; Treatment Failure | 2017 |
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Cell Proliferation; Cell Survival; Glucose; Glycolysis; HSP90 Heat-Shock Proteins; Humans; Kidney Diseases; Mice; Mitochondria; Models, Biological; Organophosphonates; Proteome; Proteomics; Succinate Dehydrogenase; Tenofovir | 2017 |
A different inhibitor is required for overcoming entecavir resistance: a comparison of four rescue therapies in a retrospective study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Practice Guidelines as Topic; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load | 2017 |
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein.
Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir | 2017 |
Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis.
Topics: Acidosis, Lactic; Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lactic Acid; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Risk Factors; Sex Factors; Tenofovir; Time Factors; Treatment Outcome; Up-Regulation; Young Adult | 2017 |
Long-term results of chronic hepatitis B antiviral treatment with nucleos(t)ide analogues: a single center experience.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Young Adult | 2019 |
Longitudinal trends in renal function in chronic hepatitis B patients receiving oral antiviral treatment.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Longitudinal Studies; Male; Middle Aged; Nutrition Surveys; Organophosphonates; Retrospective Studies; Tenofovir | 2018 |
[Marked improvement in renal tubular markers after switching from adefovir to tenofovir alafenamide in a case of Fanconi syndrome diagnosed through high ALP levels].
Topics: Adenine; Alanine; Alkaline Phosphatase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Fanconi Syndrome; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Tenofovir; Tomography, X-Ray Computed; Treatment Outcome | 2019 |
Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Chemical and Drug Induced Liver Injury; Female; Glomerular Filtration Rate; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Male; Middle Aged; Nucleotides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome | 2020 |
Is tenofovir and entecavir combination therapy still the optimal treatment for chronic hepatitis B patients with prior suboptimal response?
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Telbivudine; Tenofovir | 2020 |
Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir; Viral Load; Virus Replication | 2021 |
Aldo-keto reductase family 1 member B10 is regulated by nucleos(t)ide analogues for chronic hepatitis B.
Topics: Aldo-Keto Reductase Family 1 member B10; Aldo-Keto Reductases; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Tenofovir | 2023 |