adefovir has been researched along with pradefovir mesylate in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bullough, DA; Colby, TJ; Erion, MD; Fujitaki, JM; Linemeyer, DL; Mackenna, DA; Montag, AC; van Poelje, PD | 1 |
| Lin, CC; Peterson, J; Teng, A; Xu, C; Yeh, LT | 1 |
| Bullough, DA; Erion, MD; Hong, Z; Lin, CC | 1 |
| Benetton, S; Fang, C; Lin, CC; Xu, GF; Yeh, LT | 1 |
| Tillmann, HL | 1 |
| Boyer, SH; Colby, TJ; Craigo, W; DaRe, J; Erion, MD; Fujitaki, JM; Gómez-Galeno, JE; Matelich, MC; Ollis, K; Reddy, KR; Sun, Z; Ugarkar, BG; van Poelje, PD | 1 |
| Chen, L; Ding, Y; Wang, D; Xiao, Q; Yang, J; Yang, W | 1 |
| Chen, H; Ding, Y; Jin, W; Li, C; Li, X; Liu, C; Liu, J; Niu, J; Wu, M; Zhang, D; Zhang, H; Zhu, X | 1 |
1 review(s) available for adefovir and pradefovir mesylate
| Article | Year |
|---|---|
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.
Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Haplorhini; Hepatitis B; Humans; Liver; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphotransferases; Prodrugs; Randomized Controlled Trials as Topic; Rats | 2006 |
3 trial(s) available for adefovir and pradefovir mesylate
| Article | Year |
|---|---|
Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Dietary Fats; Double-Blind Method; Food-Drug Interactions; Humans; Male; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2005 |
Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial.
Topics: Adenine; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2016 |
Safety, efficacy, and pharmacokinetics of pradefovir for the treatment of chronic hepatitis B infection.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tenofovir; Treatment Outcome; Viral Load | 2020 |
4 other study(ies) available for adefovir and pradefovir mesylate
| Article | Year |
|---|---|
Liver-targeted drug delivery using HepDirect prodrugs.
Topics: Acetaminophen; Adenine; Analgesics, Non-Narcotic; Animals; Biotransformation; Bone Marrow; Cell Separation; Cytarabine; Drug Delivery Systems; Glutathione; Hepatocytes; In Vitro Techniques; Inactivation, Metabolic; Liver; Male; Mice; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Tissue Distribution | 2005 |
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.
Topics: Adenine; Animals; Antibodies, Monoclonal; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats | 2006 |
Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Delivery Systems; Hepatitis B, Chronic; Humans; Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Structure-Activity Relationship | 2007 |
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.
Topics: Adenine; Administration, Oral; Animals; Biological Availability; Dogs; Hepatocytes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution | 2008 |