Page last updated: 2024-08-24

adefovir and cidofovir anhydrous

adefovir has been researched along with cidofovir anhydrous in 54 studies

Research

Studies (54)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	15 (27.78)	18.2507
2000's	25 (46.30)	29.6817
2010's	13 (24.07)	24.3611
2020's	1 (1.85)	2.80

Authors

Authors	Studies
Cihlar, T; Fuller, MD; Lin, DC; Mendel, DB; Pritchard, JB; Sweet, DH	1
Cihlar, T; Ho, ES; Lin, DC; Mendel, DB	1
Cihlar, T; Ho, ES	1
Andrei, G; De Clercq, E; Holy, A; Krecmerová, M; Lebeau, I; Snoeck, R	1
Andrei, G; Crance, JM; De Clercq, E; De Vos, R; Duraffour, S; Garin, D; Holy, A; Krecmerová, M; Snoeck, R; van Den Oord, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Andrei, G; Balzarini, J; Camarasa, MJ; de Castro, S; Naesens, L; Peromingo, MT; Snoeck, R; Velázquez, S	1
Carey, AC; Cihlar, T; Fisher, R; Laflamme, G; Mackman, R; Ray, AS; Vela, JE	1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Agrofoglio, LA; Alexandre, JA; Andrei, G; Azzouzi, A; Balzarini, J; Broggi, J; Caillat, C; Deville-Bonne, D; El-Amri, C; Eriksson, S; Lin, J; Meyer, P; Pradère, U; Roy, V; Snoeck, R; Topalis, D	1
Andrei, G; Balzarini, J; Dračínský, M; Holý, A; Krečmerová, M; Snoeck, R; Tichý, T	1
Andrei, G; Balzarini, J; Hocková, D; Holý, A; Snoeck, R	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE	1
De Clercq, E; Maudgal, PC	1
Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I	1
De Clercq, E	6
Bronson, JJ; De Boeck, H; Ghazzouli, I; Hitchcock, MJ; Ho, HT; Martin, JC; Woods, K	1
Aduma, P; Connelly, MC; Fridland, A; Srinivas, RV	1
De Clercq, E; Kaminsky, R; Zweygarth, E	1
Bílá, V; Holý, A; Jelínek, R; Kren, V; Mejsnarová, B; Otová, B; Sladká, M	1
De Clercq, E; Neyts, J	1
Franková, D; Holý, A; Otová, B; Zídek, A	1
Balzarini, J; De Clercq, E; Naesens, L	1
Connely, M; Fridland, A; Srinivas, RV	1
Cundy, KC	1
Miller, DS	1
Murono, S; Pagano, JS; Raab-Traub, N	1
Hitchcock, MJ; Holý, A; Keith, KA; Kern, ER; Lee, WA	1
Andrei, G; De Clercq, E; Snoeck, R	1
Joannidis, M	1
Bleasby, K; Hall, LA; Mohrenweiser, HW; Perry, JL; Pritchard, JB	1
Morton, CJ; Ng, HL; Parker, MW; Rawlinson, WD; Scott, GM	1
Croubels, S; De Backer, P; Garré, B; Nauwynck, H; Neyts, J; Nugent, J; van der Meulen, K	1
Aldern, KA; Beadle, JR; Hartline, CB; Hostetler, KY; Keith, KA; Kern, ER; Ruiz, JC	1
Ida, H; Inui, K; Katsura, T; Tsuji, Y; Uwai, Y	1
Andrei, G; De Clercq, E; Fiten, P; Froeyen, M; Opdenakker, G; Snoeck, R	1
Alvarez, K; Barral, K; Bussetta, C; Canard, B; Deval, J; Frangeul, A	1
Balzarini, J; De Clercq, E; Koszytkowska-Stawińska, M	1
Hostetler, KY; Ray, AS	1
Leach, KL; Piotrowski, M; Wang, R; Zhang, H; Zhang, X	1
Hilgendorf, C; Jansen, K; Masereeuw, R; Nieskens, TT; Peters, JG; Röring, M; Schreurs, MJ; Smits, N; van der Made, TK; Wilmer, MJ; Woestenenk, R	1
Krecmerova, M	1
Kaltashov, IA; Xu, S	1

Reviews

13 review(s) available for adefovir and cidofovir anhydrous

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues. International journal of immunopharmacology, 1991, Volume: 13 Suppl 1 Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA, Viral; Humans; Organophosphonates; Organophosphorus Compounds	1991
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents. Drugs under experimental and clinical research, 1990, Volume: 16, Issue:7 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Retroviridae Infections; Virus Diseases	1990
Biochemical pharmacology of acyclic nucleotide analogues. Annals of the New York Academy of Sciences, 1990, Volume: 616 Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; HIV; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds	1990
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents. Postepy biochemii, 1995, Volume: 41, Issue:5 Suppl Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Stereoisomerism	1995
Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir. Clinical pharmacokinetics, 1999, Volume: 36, Issue:2 Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Drug Interactions; Humans; Infusions, Intravenous; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Insufficiency	1999
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. Clinical microbiology reviews, 2003, Volume: 16, Issue:4 Topics: Adenine; Animals; Cidofovir; Cytosine; DNA Virus Infections; DNA Viruses; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Reverse Transcriptase Inhibitors; Tenofovir	2003
Drug-induced renal failure in the ICU. The International journal of artificial organs, 2004, Volume: 27, Issue:12 Topics: Acute Kidney Injury; Adenine; Amphotericin B; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Calcineurin Inhibitors; Cidofovir; Cyclooxygenase Inhibitors; Cytosine; Foscarnet; Hemodynamics; Humans; Hydroxyethyl Starch Derivatives; Immunoglobulins, Intravenous; Intensive Care Units; Kidney; Organophosphonates; Tacrolimus	2004
The discovery of antiviral agents: ten different compounds, ten different stories. Medicinal research reviews, 2008, Volume: 28, Issue:6 Topics: Acyclovir; Adenine; Antiviral Agents; Benzodiazepines; Benzylamines; Cidofovir; Cyclams; Cytosine; Heterocyclic Compounds; Humans; Imidazoles; Nucleosides; Organophosphonates; Tenofovir; Valacyclovir; Valine; Virus Diseases	2008
Application of kinase bypass strategies to nucleoside antivirals. Antiviral research, 2011, Volume: 92, Issue:2 Topics: Adenine; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytosine; History, 20th Century; History, 21st Century; Humans; Nucleosides; Nucleotides; Organophosphonates; Phosphotransferases; Tenofovir	2011
The Holý Trinity: the acyclic nucleoside phosphonates. Advances in pharmacology (San Diego, Calif.), 2013, Volume: 67 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Humans; Nucleosides; Organophosphonates; Prodrugs; Tenofovir; Virus Diseases	2013
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals. Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:10 Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; Humans; Nucleosides; Nucleotides; Organophosphonates; Prodrugs	2017

Other Studies

41 other study(ies) available for adefovir and cidofovir anhydrous

Article	Year
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1. Molecular pharmacology, 1999, Volume: 56, Issue:3 Topics: Adenine; Amino Acid Sequence; Animals; Anion Transport Proteins; Antiviral Agents; Base Sequence; Biological Transport; Carrier Proteins; Cidofovir; Cloning, Molecular; Cytosine; DNA, Complementary; Humans; Immunoblotting; Kidney; Molecular Sequence Data; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats	1999
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1. Journal of the American Society of Nephrology : JASN, 2000, Volume: 11, Issue:3 Topics: Adenine; Alanine; Animals; Anion Transport Proteins; Antiviral Agents; Biological Transport; Carrier Proteins; CHO Cells; Cidofovir; Cricetinae; Cytosine; Humans; Kidney; Organophosphate Poisoning; Organophosphonates; Organophosphorus Compounds; Probenecid	2000
Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Analytical biochemistry, 2000, Jul-15, Volume: 283, Issue:1 Topics: Animals; Anion Transport Proteins; Anions; Arylsulfonates; Boron Compounds; Carrier Proteins; CHO Cells; Cricetinae; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescein; Fluoresceins; Fluorescent Dyes; Glutarates; Humans; Inhibitory Concentration 50; Kinetics; Models, Chemical; Spectrometry, Fluorescence; Time Factors; Transfection	2000
Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Animals; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Mice; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Polyomavirus; Pyrimidine Nucleosides; Pyrimidines; Simian virus 40	2007
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Male; Mice; Microscopy, Electron, Transmission; Nucleosides; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Swiss 3T3 Cells; Virus Replication	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
4"-Benzoylureido-TSAO derivatives as potent and selective non-nucleoside HCMV inhibitors. Structure-activity relationship and mechanism of antiviral action. Journal of medicinal chemistry, 2008, Sep-25, Volume: 51, Issue:18 Topics: Antiviral Agents; Cell Line; Cytomegalovirus; Humans; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Thymidine; Urea	2008
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir	2009
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates. Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1 Topics: Antiviral Agents; Catalytic Domain; Cells, Cultured; Crystallography, X-Ray; Herpesviridae; Humans; Ligands; Models, Molecular; Molecular Structure; Nucleoside-Phosphate Kinase; Organophosphonates; Prodrugs; Pyrimidine Nucleosides; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity; Thymidine; Thymidine Kinase	2011
New prodrugs of Adefovir and Cidofovir. Bioorganic & medicinal chemistry, 2011, Jun-01, Volume: 19, Issue:11 Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus	2011
Acyclic nucleoside phosphonates with a branched 2-(2-phosphonoethoxy)ethyl chain: efficient synthesis and antiviral activity. Bioorganic & medicinal chemistry, 2011, Aug-01, Volume: 19, Issue:15 Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Herpes Simplex; HIV; HIV Infections; Humans; Mice; Nucleosides; Organophosphonates; Simplexvirus; Structure-Activity Relationship; Vaccinia; Vaccinia virus; Virus Diseases; Viruses	2011
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; Herpes Simplex; Immune Tolerance; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Opportunistic Infections; Organophosphonates; Organophosphorus Compounds	1991
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits. Antiviral research, 1991, Volume: 16, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Hempa; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Thymidine Kinase	1991
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro. Antiviral research, 1990, Volume: 13, Issue:6 Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin	1990
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates. Molecular pharmacology, 1995, Volume: 47, Issue:4 Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Foscarnet; Organophosphonates; Organophosphorus Compounds; Vero Cells	1995
Antitrypanosomal activity of phosphonylmethoxyalkylpurines. The Journal of parasitology, 1994, Volume: 80, Issue:6 Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African	1994
Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA). Folia biologica, 1993, Volume: 39, Issue:3 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Chick Embryo; Cidofovir; Cytosine; Female; Fibroblasts; Humans; Lung; Male; Mitosis; Organophosphonates; Organophosphorus Compounds; Polydactyly; Rats; Rats, Inbred BN; Rats, Inbred Lew	1993
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication. Biochemical pharmacology, 1994, Jan-13, Volume: 47, Issue:1 Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Nucleus; Cidofovir; Cytosine; Herpesviridae; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Structure-Activity Relationship; Thymidine Kinase; Virus Replication	1994
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs. European journal of pharmacology, 1995, Nov-24, Volume: 286, Issue:3 Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred BN; Rats, Inbred Lew	1995
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes. Antiviral research, 1997, Volume: 35, Issue:1 Topics: Adenine; Anti-HIV Agents; Antiviral Agents; CD4 Antigens; Cell Line; Cidofovir; Cytosine; Genetic Engineering; HeLa Cells; Herpesvirus 1, Human; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Phosphorylation; T-Lymphocytes; Virus Replication	1997
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Kidney Tubules, Proximal; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Agents; Xenobiotics	2001
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs. Cancer research, 2001, Nov-01, Volume: 61, Issue:21 Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Division; Cidofovir; Cytosine; Epithelial Cells; Growth Inhibitors; Herpesvirus 4, Human; Humans; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Xenograft Model Antitumor Assays	2001
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication. Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:7 Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Poxviridae Infections; Prodrugs; Skin; Tenofovir; Virus Replication	2003
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir? Antiviral research, 2004, Volume: 61, Issue:3 Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins	2004
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6). The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2 Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA; Genetic Variation; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transport Protein 1; Organophosphonates; p-Aminohippuric Acid; Polymorphism, Single Nucleotide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Complementary; Tenofovir; Xenopus laevis	2005
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus. The Journal of general virology, 2005, Volume: 86, Issue:Pt 8 Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Ganciclovir; Guanine; Humans; Mice; Models, Molecular; Molecular Sequence Data; Muromegalovirus; Mutation; Organophosphonates; Protein Kinases; Sequence Alignment; Valacyclovir; Valine; Virus Replication	2005
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge. Biochemical pharmacology, 2007, Apr-01, Volume: 73, Issue:7 Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses	2007
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet. Veterinary microbiology, 2007, May-16, Volume: 122, Issue:1-2 Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Epithelial Cells; Foscarnet; Ganciclovir; Herpesvirus 1, Equid; Horses; Lung; Organophosphonates	2007
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir. Antiviral research, 2007, Volume: 75, Issue:1 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cowpox; Cytomegalovirus Infections; Cytosine; Herpes Simplex; HIV-1; Humans; In Vitro Techniques; Molecular Structure; Organophosphonates; Sensitivity and Specificity; Vaccinia	2007
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2). Pharmaceutical research, 2007, Volume: 24, Issue:4 Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Humans; Kidney; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Probenecid; Tenofovir; Transfection	2007
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions. Antiviral therapy, 2007, Volume: 12, Issue:5 Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Disease Models, Animal; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Exodeoxyribonucleases; Foscarnet; Genotype; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Models, Molecular; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Phenotype; Protein Binding; Protein Conformation; Vero Cells; Viral Proteins; Virulence	2007
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues. Antiviral therapy, 2008, Volume: 13, Issue:1 Topics: Adenine; Anti-HIV Agents; Binding Sites; Cidofovir; Cytosine; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Organophosphonates; Protein Conformation; Tenofovir	2008
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain. Bioorganic & medicinal chemistry, 2009, Jun-01, Volume: 17, Issue:11 Topics: Acids, Acyclic; Adenine; Antiviral Agents; Aza Compounds; Cidofovir; Cytosine; DNA Viruses; HeLa Cells; Humans; Molecular Structure; Nucleosides; Organophosphonates; RNA Viruses; Tenofovir	2009
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:1 Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Organic Anion Transport Protein 1; Organophosphonates; Tenofovir; Toxicity Tests	2015
A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity. The AAPS journal, 2016, Volume: 18, Issue:2 Topics: 3T3 Cells; Adenine; Animals; Antiviral Agents; Cell Line; Cell Line, Transformed; Cell Survival; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Forecasting; Gene Expression Regulation; HEK293 Cells; Humans; Kidney Tubules, Proximal; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates	2016
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein. Molecular pharmaceutics, 2017, 08-07, Volume: 14, Issue:8 Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir	2017