Page last updated: 2024-08-21

adamantane and sphingosine kinase

adamantane has been researched along with sphingosine kinase in 26 studies

Research

Studies (26)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	25 (96.15)	24.3611
2020's	1 (3.85)	2.80

Authors

Authors	Studies
Beljanski, V; French, KJ; Gao, P; Green, CL; Keller, SN; Maines, LW; Smith, CD; Upson, JJ; Wang, W; Zhuang, Y	1
Fitzpatrick, LR; Green, CL; Maines, LW; Smith, CD; Zhuang, Y	1
Beljanski, V; Knaak, C; Smith, CD	1
Beljanski, V; Knaak, C; Smith, CD; Zhuang, Y	1
Chumanevich, AA; Cui, X; Davis, T; Hofseth, LJ; Poudyal, D; Smith, CD; Wood, PA	1
Antoon, JW; Ashe, HB; Beckman, BS; Burow, ME; Elliott, S; Meacham, WD; Muir, SE; Rhodes, LV; Slaughter, EM; Smith, CD; White, MD; Wiese, TE	1
Donahue, H; Fitzpatrick, LR; Frauenhoffer, EE; French, KJ; Green, C; Maines, LW; Mosher, TJ; Paul, E; Smith, CD; Upson, JJ; Zhuang, Y	1
Beljanski, V; Lewis, CS; Smith, CD	1
Antoon, JW; Beckman, BS; Burow, ME; Driver, JL; Elliott, S; Khalili, HS; Slaughter, EM; Smith, CD; White, MD	1
Fitzpatrick, LR; Green, C; Maines, LW; Smith, CD	1
Krishnasamy, Y; Lemasters, JJ; Liu, Q; Ramshesh, VK; Rehman, H; Schwartz, J; Shi, Y; Smith, CD; Zhang, X; Zhong, Z	1
Bergonzini, V; Bot, M; Costa, S; Freise, H; Maines, L; Nofer, JR; Poti, F; Robenek, H; Simoni, M; Varga, G	1
Krishnasamy, Y; Lemasters, JJ; Liu, Q; Rehman, H; Shi, Y; Smith, CD; Zhong, Z	1
Antoon, JW; Beckman, BS; Burow, ME; Driver, JL; White, MD	1
Oates, JC; Obeid, LM; Ruiz, P; Snider, AJ	1
Antoon, JW; Beckman, BS; Chan, L; White, MD	1
Bonstaff, K; Dai, L; Del Valle, L; Flemington, E; Ogretmen, B; Parsons, C; Qin, Z; Reske, T; Rodriguez, P; Senkal, C; Smith, CD; Trillo-Tinoco, J; Voelkel-Johnson, C; Wang, W	1
Bendall, LJ; Bradstock, KF; Pitson, SM; Powell, JA; Tong, D; Wallington-Beddoe, CT	1
Antoon, JW; Beckman, BS; Burow, ME; Gestaut, MM	1
Difiglia, M; Felice, VD; Qin, T; Qin, ZH; Sapp, E; Sheng, R; Smith, CD; Waeber, C; Zhang, TT	1
Li, Z; Mei, Z; Shi, L; Shi, M; Sun, S; Wang, Y; Wang, Z; Xie, C; Yang, C; Yang, J; Zhang, S	1
McNaughton, M; Pitman, M; Pitson, SM; Pyne, NJ; Pyne, S	1
Bandara, G; Desai, A; Komarow, HD; Metcalfe, DD; Muñoz-Cano, R; Olivera, A; Tobío, A; Yin, Y	1
Hahm, B; Seo, YJ; Studstill, CJ; Vijayan, M; Wolf, JJ; Xia, C	1
Alsanafi, M; Jubair, K; Kelly, SL; McNaughton, M; Merrill, AH; Pyne, NJ; Pyne, S; Tate, RJ	1
Cheon, H; Dunton, W; Feith, DJ; LeBlanc, FR; Loughran, TP; Pearson, JM; Tan, SF; Xing, JC	1

Other Studies

26 other study(ies) available for adamantane and sphingosine kinase

Article	Year
Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:1 Topics: Adamantane; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biological Availability; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Sprague-Dawley	2010
Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease. Inflammopharmacology, 2010, Volume: 18, Issue:2 Topics: Adamantane; Aminosalicylic Acids; Animals; Body Weight; Colon; Crohn Disease; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epithelial Cells; Female; Gastrointestinal Agents; Humans; Interleukin-1beta; Leukocytes; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Phosphotransferases (Alcohol Group Acceptor); Prednisolone; Pyridines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha	2010
A novel sphingosine kinase inhibitor induces autophagy in tumor cells. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:2 Topics: Adamantane; Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Mice; Mice, SCID; Microscopy, Confocal; Microtubule-Associated Proteins; Mitochondrial Membranes; Neoplasm Transplantation; Neoplasms, Experimental; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Pyridines; RNA, Small Interfering; Tumor Cells, Cultured; Unfolded Protein Response	2010
Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Investigational new drugs, 2011, Volume: 29, Issue:6 Topics: Adamantane; Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Caspase 3; Caspase 7; Catechols; Cell Line, Tumor; DNA Fragmentation; Drug Synergism; Female; Humans; Kidney Neoplasms; Mice; Mice, SCID; Niacinamide; Pancreatic Neoplasms; Phenylurea Compounds; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sorafenib; Xenograft Model Antitumor Assays	2011
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. Carcinogenesis, 2010, Volume: 31, Issue:10 Topics: Adamantane; Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Extracellular Signal-Regulated MAP Kinases; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyridines; Sphingosine	2010
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640. Endocrinology, 2010, Volume: 151, Issue:11 Topics: Adamantane; Analysis of Variance; Animals; Blotting, Western; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Estradiol; Female; Gene Expression; Humans; Immunohistochemistry; Mice; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription, Genetic	2010
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase. Inflammopharmacology, 2011, Volume: 19, Issue:2 Topics: Adamantane; Administration, Oral; Animals; Ankle; Ankle Joint; Arthritis, Experimental; Body Weight; Drug Therapy, Combination; Edema; Enzyme Inhibitors; Female; Foot; Indomethacin; Inflammation; Methotrexate; Mice; Mice, Inbred DBA; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Inbred Lew; Splenomegaly; X-Ray Microtomography	2011
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts. Cancer biology & therapy, 2011, Mar-01, Volume: 11, Issue:5 Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Blotting, Western; Carcinoma, Hepatocellular; Flow Cytometry; Hep G2 Cells; Humans; Liver Neoplasms; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Niacinamide; Phenylurea Compounds; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sorafenib; Sphingosine; Xenograft Model Antitumor Assays	2011
Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer biology & therapy, 2011, Apr-01, Volume: 11, Issue:7 Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Mice; Mice, SCID; Molecular Targeted Therapy; NF-kappaB-Inducing Kinase; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Pyridines; Receptors, Estrogen; Signal Transduction; Xenograft Model Antitumor Assays	2011
Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2. Pharmacology, 2011, Volume: 87, Issue:3-4 Topics: Adamantane; Animals; Apoptosis; Chondrocytes; Disease Models, Animal; Iodoacetates; Male; Osteoarthritis; Pain; Pain Measurement; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Wistar	2011
Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. Journal of hepatology, 2012, Volume: 56, Issue:1 Topics: Adamantane; Animals; Cell Death; Enzyme Inhibitors; Gene Knockdown Techniques; Hepatocytes; In Vitro Techniques; Inflammation; Liver; Lysophospholipids; Male; Mice; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nitric Oxide Synthase Type II; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Reperfusion Injury; RNA, Messenger; RNA, Small Interfering; Sphingosine	2012
Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice. Thrombosis and haemostasis, 2012, Volume: 107, Issue:3 Topics: Adamantane; Animals; Atherosclerosis; Cell Adhesion Molecules; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Enzyme Inhibitors; Humans; Inflammation Mediators; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Pyridines; Receptors, LDL; Serine Endopeptidases; T-Lymphocytes	2012
Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. PloS one, 2012, Volume: 7, Issue:7 Topics: Adamantane; Animals; Cell Adhesion Molecules; Chemokines; Enzyme Inhibitors; Inflammation; Leukocytes; Liver; Liver Transplantation; Lysophospholipids; Male; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Reperfusion Injury; Sphingosine; Toll-Like Receptor 4; Up-Regulation	2012
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer. Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:7 Topics: Adamantane; Aminophenols; Animals; Antineoplastic Agents, Hormonal; Base Sequence; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Drug Resistance, Neoplasm; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoenzymes; Mice; Mice, Nude; Mice, SCID; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Thiazoles; Xenograft Model Antitumor Assays	2012
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis. PloS one, 2013, Volume: 8, Issue:1 Topics: Adamantane; Albumins; Animals; Cell Separation; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Enzymologic; Inflammation; Isoenzymes; Kidney Glomerulus; Lupus Nephritis; Mice; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sphingolipids; Spleen; Thromboxane B2	2013
Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640. Anticancer research, 2013, Volume: 33, Issue:9 Topics: Adamantane; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Ovarian Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyridines	2013
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. Molecular cancer therapeutics, 2014, Volume: 13, Issue:1 Topics: Adamantane; Apoptosis; Cell Line, Tumor; Cell Proliferation; Herpesvirus 8, Human; Humans; Lymphoma, Primary Effusion; Lysophospholipids; Molecular Targeted Therapy; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Signal Transduction; Sphingosine	2014
Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression. Cancer research, 2014, May-15, Volume: 74, Issue:10 Topics: Acetylation; Adamantane; Animals; Caspases; Cell Death; Cell Growth Processes; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Genes, myc; HEK293 Cells; Histones; Humans; K562 Cells; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Phosphotransferases (Alcohol Group Acceptor); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; Pyridines; Xenograft Model Antitumor Assays	2014
Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival. Pharmacological reports : PR, 2014, Volume: 66, Issue:1 Topics: Adamantane; Androgen Antagonists; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Humans; Ki-67 Antigen; Male; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Pyridines	2014
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons. The Journal of biological chemistry, 2014, Jul-25, Volume: 289, Issue:30 Topics: Adamantane; Anesthetics, Inhalation; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Ischemic Preconditioning; Isoflurane; Lactosylceramides; Mice; Mice, Knockout; Morpholines; Neurons; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrones; Transcription Factor TFIIH; Transcription Factors	2014
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer. Cancer biology & therapy, 2015, Volume: 16, Issue:8 Topics: Adamantane; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Protein Transport; Pyridines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand	2015
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells. Oncotarget, 2016, Mar-29, Volume: 7, Issue:13 Topics: Adamantane; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Male; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms, Castration-Resistant; Proteasome Endopeptidase Complex; Pyridines; Thiazoles	2016
Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT. Frontiers in immunology, 2018, Volume: 9 Topics: Adamantane; Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Cell Survival; DNA Repair; Hematologic Neoplasms; Humans; Hydrazines; Mast Cells; Mastocytosis; Mice; Mice, Knockout; Mutation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyridines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2018
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice. Antiviral research, 2018, Volume: 158 Topics: A549 Cells; Adamantane; Administration, Oral; Amino Alcohols; Aminophenols; Animals; Cell Line; Disease Models, Animal; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Pyridines; RNA, Small Interfering; Sphingosine; Thiazoles; Virus Replication	2018
Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival. Molecular and cellular biology, 2018, 12-01, Volume: 38, Issue:23 Topics: Adamantane; Apoptosis; Cell Line; Cell Survival; Fatty Acid Desaturases; HEK293 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Kidney; Oxidoreductases; p38 Mitogen-Activated Protein Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyridines; Sphingosine; Ubiquitin-Protein Ligases; Ubiquitination; X-Box Binding Protein 1	2018
Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1. British journal of haematology, 2020, Volume: 190, Issue:3 Topics: Adamantane; Adult; Aged; Apoptosis; Enzyme Induction; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Large Granular Lymphocytic; Leukocytes, Mononuclear; Lysophospholipids; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Peptide Fragments; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Pyridines; RNA Interference; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Sphingosine; Thiazolidinediones; Up-Regulation	2020