adamantane has been researched along with adarotene in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (44.44) | 29.6817 |
| 2010's | 13 (48.15) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Carminati, P; Cincinelli, R; Dallavalle, S; Gaetano, C; Giannini, G; Illy, B; Merlini, L; Penco, S; Pisano, C; Supino, R; Vesci, L; Zuco, V; Zunino, F | 1 |
| Carminati, P; Chiarucci, I; Diomede, L; Ferrara, FF; Garattini, E; Gianni', M; Kalac, Y; Merlini, L; Parrella, E; Pisano, C; Simoni, D; Terao, M; Zanier, R | 1 |
| Cassinelli, G; Garattini, E; Giordano, V; Lanzi, C; Pisano, C; Supino, R; Zanchi, C; Zanier, R; Zuco, V; Zunino, F | 1 |
| Carminati, P; Merlini, L; Penco, S; Pisano, C; Zunino, F | 1 |
| Lanzi, C; Supino, R; Zanchi, C; Zuco, V; Zunino, F | 1 |
| Aulicino, C; Barbarino, M; Beretta, GL; Bucci, F; Carminati, P; Lanzi, C; Pisano, C; Supino, R; Zanchi, C; Zanier, R; Zuco, V; Zunino, F | 1 |
| Kadara, H; Lotan, D; Lotan, R; Pisano, C; Schroeder, CP | 1 |
| Barzago, MM; Carminati, P; Dallavalle, S; Diomede, L; Fratelli, M; Garattini, E; Giannì, M; Kurosaki, M; Merlini, L; Parrella, E; Pisano, C; Raska, I; Rochette-Egly, C; Tavecchio, M; Terao, M | 1 |
| Barone, G; Carminati, P; D'Incalci, M; Di Francesco, AM; Meco, D; Pisano, C; Riccardi, R; Torella, AR | 1 |
| De Cesare, M; Ferrara, FF; Foderà, R; Pisano, C; Pratesi, G; Rossi, C; Supino, R; Vesci, L; Zuco, V; Zunino, F | 1 |
| Antoccia, A; Boldetti, A; Cenciarelli, C; Di Francesco, AM; Erba, E; Fratelli, M; Garattini, E; Gianni', M; Merlini, L; Paroni, G; Pisano, C; Riccardi, R; Tavecchio, M; Terao, M; Valli, C | 1 |
| Benedetti, V; De Cesare, M; Zuco, V; Zunino, F | 1 |
| Bagnati, R; Capocasa, F; D'Incalci, M; Marangon, E; Pace, S; Sala, F; Zucchetti, M | 1 |
| Barone, G; Cusano, G; D'Incalci, M; Di Francesco, AM; Meco, D; Pierri, F; Pisano, C; Riccardi, R; Torella, AR; Ubezio, P | 1 |
| Di Francesco, AM; Fisher, JN; Fratelli, M; Garattini, E; Gianni, M; Gobbi, M; Godl, K; Marx, S; Paroni, G; Pierri, F; Pisano, C; Stravalaci, M; Tebbe, A; Terao, M; Valli, C | 1 |
| Abdel-Samad, R; Bazarbachi, A; Darwiche, N; Dbaibo, G; El Hajj, H; Ghandour, B; Ghantous, A; Hall, WW; Hasegawa, H; Jabbour, M; Khalil, B; Nasr, R; Pisano, C; Shahine, S; Sinjab, A; Zaatari, G | 1 |
| Césaire, R; Meniane, JC | 1 |
| Darwiche, ND; El-Eit, RM; Hmadi, RA; Iskandarani, AN; Jabbour, MN; Mahon, FX; Nasr, RR; Pisano, CC; Zaatari, GS | 1 |
| Cusano, G; Di Francesco, AM; Falconi, M; Franzese, O; Orienti, I; Riccardi, R; Vesci, L | 1 |
| Basma, H; Darwiche, N; Dweik, L; El-Eit, R; Ghamloush, F; Ghayad, SE; Harajly, M; Mancinelli, A; Pisano, C; Rabeh, W; Rammal, G; Saab, R; Zalzali, H | 1 |
| Huang, YX; Tao, JG; Zhao, HX | 1 |
| Abdel-Samad, R; Aouad, P; Darwiche, N; El-Houjeiri, L; Fostok, S; Pisano, C; Saikali, M; Talhouk, R | 1 |
| Abdel-Samad, R; Abou Merhi, R; Darwiche, N; Halloum, I; Houshaymi, B; Jaafar, M; Karam, L; Neipel, F; Pisano, C | 1 |
| Dong, Z; Yuan, Y | 1 |
| Abdel-Samad, R; Abou-Kheir, W; Bahmad, HF; Cheaito, K; Darwiche, N; Hadadeh, O; Hayar, B; Liu, YN; Monzer, A; Msheik, H; Pisano, C; Samman, H | 1 |
| De, L; Yong, Z; Yuan, T | 1 |
| Darwiche, N; Dbaibo, G; Ghandour, B; Pisano, C | 1 |
1 review(s) available for adamantane and adarotene
| Article | Year |
|---|---|
Cellular and pharmacological bases of the antitumor activity of a novel adamantyl retinoid, ST1926.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cinnamates; Disease Models, Animal; Humans; Leukemia, Myeloid, Acute; Mice; Neoplasms; Sensitivity and Specificity; Treatment Outcome; Tumor Cells, Cultured | 2004 |
1 trial(s) available for adamantane and adarotene
| Article | Year |
|---|---|
Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ST1926, a novel oral antitumor agent, adamantyl retinoid derivative, in plasma of patients in a Phase I study.
Topics: Adamantane; Antineoplastic Agents; Calibration; Chromatography, High Pressure Liquid; Cinnamates; Drug Stability; Female; Humans; Linear Models; Ovarian Neoplasms; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2009 |
25 other study(ies) available for adamantane and adarotene
| Article | Year |
|---|---|
A novel atypical retinoid endowed with proapoptotic and antitumor activity.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cinnamates; DNA Damage; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Mice; Mice, Nude; Ovarian Neoplasms; Protein Isoforms; Receptors, Retinoic Acid; Retinoids; Structure-Activity Relationship; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis.
Topics: Adamantane; Antineoplastic Agents; Apoptosis; Calcium; Cell Line, Tumor; Chelating Agents; Cinnamates; Dihydropyridines; Egtazic Acid; Gene Expression; HeLa Cells; Homeostasis; Humans; Intracellular Fluid; JNK Mitogen-Activated Protein Kinases; Leukemia, Myeloid; Mitochondria; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Receptors, Retinoic Acid; Retinoic Acid Receptor gamma; Retinoids | 2004 |
Induction of apoptosis and stress response in ovarian carcinoma cell lines treated with ST1926, an atypical retinoid.
Topics: Adamantane; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma; Caspases; Cell Division; Cell Line, Tumor; Cinnamates; DNA Damage; DNA Repair; DNA, Neoplasm; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinases; Molecular Structure; Ovarian Neoplasms; Proliferating Cell Nuclear Antigen; Stress, Physiological; Transcription Factor AP-1; Tumor Suppressor Protein p53 | 2004 |
Modulation of survival signaling pathways and persistence of the genotoxic stress as a basis for the synergistic interaction between the atypical retinoid ST1926 and the epidermal growth factor receptor inhibitor ZD1839.
Topics: Adamantane; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Caspase 8; Caspases; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Cinnamates; DNA Damage; Drug Synergism; Enzyme Activation; ErbB Receptors; Female; Gefitinib; Humans; Ovarian Neoplasms; Quinazolines; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; Vulvar Neoplasms | 2005 |
Development of resistance to the atypical retinoid, ST1926, in the lung carcinoma cell line H460 is associated with reduced formation of DNA strand breaks and a defective DNA damage response.
Topics: Adamantane; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cinnamates; Cytochromes c; DNA; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Flow Cytometry; Gene Expression Regulation, Neoplastic; Histones; Humans; In Situ Nick-End Labeling; Membrane Potentials; Mitochondria; Phosphorylation; Retinoids; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2005 |
Induction of GDF-15/NAG-1/MIC-1 in human lung carcinoma cells by retinoid-related molecules and assessment of its role in apoptosis.
Topics: Adamantane; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Large Cell; Cinnamates; Cytokines; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; Humans; Lung Neoplasms; Oncogene Proteins, Viral; Poly(ADP-ribose) Polymerases; Repressor Proteins; Retinoids; RNA, Small Interfering; Tretinoin; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2006 |
Antitumor activity of the retinoid-related molecules (E)-3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid (ST1926) and 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) in F9 teratocarcinoma: Role of retinoic acid receptor gamm
Topics: Adamantane; Animals; Antineoplastic Agents; Calcium; Cell Death; Cell Differentiation; Cells, Cultured; Chlorocebus aethiops; Cinnamates; COS Cells; Cytosol; Disease Models, Animal; G2 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Receptors, Retinoic Acid; Retinoic Acid Receptor gamma; Retinoids; RNA, Messenger; Teratocarcinoma; Tretinoin | 2006 |
The novel atypical retinoid ST1926 is active in ATRA resistant neuroblastoma cells acting by a different mechanism.
Topics: Adamantane; Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cinnamates; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Humans; Male; Mice; Mice, Nude; Molecular Structure; Neuroblastoma; Tretinoin | 2007 |
Antitumor activity of the combination of synthetic retinoid ST1926 and cisplatin in ovarian carcinoma models.
Topics: Adamantane; Animals; Antineoplastic Combined Chemotherapy Protocols; Cinnamates; Cisplatin; Female; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2007 |
Atypical retinoids ST1926 and CD437 are S-phase-specific agents causing DNA double-strand breaks: significance for the cytotoxic and antiproliferative activity.
Topics: Adamantane; Animals; Cell Death; Cell Line, Tumor; Cell Proliferation; CHO Cells; Chromosome Aberrations; Cinnamates; Cricetinae; Cricetulus; DNA Breaks, Double-Stranded; DNA Repair; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Histones; Humans; Phosphorylation; Protein Kinases; Recombination, Genetic; Retinoids; S Phase | 2008 |
Sensitization of ovarian carcinoma cells to the atypical retinoid ST1926 by the histone deacetylase inhibitor, RC307: enhanced DNA damage response.
Topics: Adamantane; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cinnamates; DNA Damage; Enzyme Inhibitors; Female; Histone Deacetylases; Humans; In Situ Nick-End Labeling; Mice; Mice, Nude; Ovarian Neoplasms; Retinoids; Xenograft Model Antitumor Assays | 2010 |
Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models.
Topics: Adamantane; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Blotting, Western; Bromodeoxyuridine; Caspase 3; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cinnamates; DNA Damage; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mice; Models, Biological; Neuroblastoma; Propidium; Receptors, Death Domain; Tretinoin | 2012 |
New insights into the molecular mechanisms underlying sensitivity/resistance to the atypical retinoid ST1926 in acute myeloid leukaemia cells: the role of histone H2A.Z, cAMP-dependent protein kinase A and the proteasome.
Topics: Acute Disease; Adamantane; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Survival; Cinnamates; Cyclic AMP-Dependent Protein Kinases; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histones; Humans; Isoquinolines; Leukemia, Myeloid; Leupeptins; Oligonucleotide Array Sequence Analysis; Proteasome Endopeptidase Complex; Protein Binding; Signal Transduction; Sulfonamides; Surface Plasmon Resonance | 2013 |
Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamates; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; Gene Expression Regulation, Neoplastic; Gene Products, tax; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemic Infiltration; Mice; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
ST1926 repression of Tax: ATL targeted treatment?
Topics: Adamantane; Animals; Antineoplastic Agents; Cinnamates; Humans; Leukemia-Lymphoma, Adult T-Cell | 2014 |
ST1926, an orally active synthetic retinoid, induces apoptosis in chronic myeloid leukemia cells and prolongs survival in a murine model.
Topics: Adamantane; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cinnamates; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Enzyme Activation; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Membrane Potential, Mitochondrial; Mice; Reactive Oxygen Species; Retinoids; Signal Transduction; Tumor Burden; Xenograft Model Antitumor Assays | 2015 |
Resistance to the atypical retinoid ST1926 in SK-N-AS cells selected the subline rAS-ST with enhanced sensitivity to ATRA mediated by not conventional mechanisms: DNA damage, G2 accumulation and late telomerase inhibition.
Topics: Adamantane; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cinnamates; Comet Assay; DNA Damage; Drug Resistance, Neoplasm; Humans; Proto-Oncogene Proteins c-akt; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Telomerase; Tretinoin | 2015 |
The synthetic retinoid ST1926 as a novel therapeutic agent in rhabdomyosarcoma.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Survival; Cinnamates; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Heterografts; Humans; Mice; Oncogene Proteins, Fusion; Rhabdomyosarcoma; S Phase Cell Cycle Checkpoints; Signal Transduction; Tumor Suppressor Protein p53 | 2016 |
ST1926 Attenuates Steroid-Induced Osteoporosis in Rats by Inhibiting Inflammation Response.
Topics: Adamantane; Alkaline Phosphatase; Animals; beta Catenin; Bone Density; Bone Density Conservation Agents; Bone Morphogenetic Proteins; Bone Resorption; Cinnamates; Gene Expression Regulation; Male; Methylprednisolone; Methylprednisolone Acetate; NF-kappa B; Osteoblasts; Osteoclasts; Osteonecrosis; Osteoprotegerin; Rats; Rats, Wistar; Signal Transduction; Wnt3A Protein | 2017 |
Antitumor activities of the synthetic retinoid ST1926 in two-dimensional and three-dimensional human breast cancer models.
Topics: Adamantane; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cinnamates; Female; Humans; MCF-7 Cells; Triple Negative Breast Neoplasms | 2017 |
Antitumor activity of the synthetic retinoid ST1926 on primary effusion lymphoma in vitro and in vivo models.
Topics: Adamantane; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cinnamates; DNA Damage; Gene Expression Regulation, Neoplastic; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Lymphoma, Primary Effusion; Mice; Treatment Outcome; Xenograft Model Antitumor Assays | 2018 |
Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Ιnhibition by ST1926.
Topics: Acute Lung Injury; Adamantane; Animals; Cell Line; Cinnamates; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oxidative Stress | 2018 |
The synthetic retinoid ST1926 attenuates prostate cancer growth and potentially targets prostate cancer stem-like cells.
Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cinnamates; DNA Damage; Humans; Male; Mice; Neoplasm Invasiveness; Neoplastic Stem Cells; Prostate; Prostatic Neoplasms; Retinoids; Xenograft Model Antitumor Assays | 2019 |
ST1926 inhibits glioma progression through regulating mitochondrial complex II.
Topics: Adamantane; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cinnamates; Disease Progression; Electron Transport Complex II; Energy Metabolism; Enzyme Inhibitors; Glioma; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Mitochondria; Reactive Oxygen Species; Tumor Burden; Xenograft Model Antitumor Assays | 2020 |
Restoration of ceramide de novo synthesis by the synthetic retinoid ST1926 as it induces adult T-cell leukemia cell death.
Topics: Adamantane; Antineoplastic Agents; Cell Death; Ceramides; Cinnamates; Enzyme Activation; Gene Products, tax; Human T-lymphotropic virus 1; Humans; Jurkat Cells; Leukemia-Lymphoma, Adult T-Cell; Oxidoreductases; Proteolysis; Proto-Oncogene Proteins c-bcl-2; Time Factors | 2020 |