Compounds > adamantane
Page last updated: 2024-08-21

adamantane and 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide

adamantane has been researched along with 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide in 44 studies

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's40 (90.91)24.3611
2020's4 (9.09)2.80

Authors

AuthorsStudies
Beljanski, V; French, KJ; Gao, P; Green, CL; Keller, SN; Maines, LW; Smith, CD; Upson, JJ; Wang, W; Zhuang, Y1
Fitzpatrick, LR; Green, CL; Maines, LW; Smith, CD; Zhuang, Y1
Beljanski, V; Knaak, C; Smith, CD1
Beljanski, V; Knaak, C; Smith, CD; Zhuang, Y1
Chumanevich, AA; Cui, X; Davis, T; Hofseth, LJ; Poudyal, D; Smith, CD; Wood, PA1
Antoon, JW; Ashe, HB; Beckman, BS; Burow, ME; Elliott, S; Meacham, WD; Muir, SE; Rhodes, LV; Slaughter, EM; Smith, CD; White, MD; Wiese, TE1
Donahue, H; Fitzpatrick, LR; Frauenhoffer, EE; French, KJ; Green, C; Maines, LW; Mosher, TJ; Paul, E; Smith, CD; Upson, JJ; Zhuang, Y1
Beljanski, V; Lewis, CS; Smith, CD1
Antoon, JW; Beckman, BS; Burow, ME; Driver, JL; Elliott, S; Khalili, HS; Slaughter, EM; Smith, CD; White, MD1
Fitzpatrick, LR; Green, C; Maines, LW; Smith, CD1
Krishnasamy, Y; Lemasters, JJ; Liu, Q; Ramshesh, VK; Rehman, H; Schwartz, J; Shi, Y; Smith, CD; Zhang, X; Zhong, Z1
Bergonzini, V; Bot, M; Costa, S; Freise, H; Maines, L; Nofer, JR; Poti, F; Robenek, H; Simoni, M; Varga, G1
Krishnasamy, Y; Lemasters, JJ; Liu, Q; Rehman, H; Shi, Y; Smith, CD; Zhong, Z1
Antoon, JW; Beckman, BS; Burow, ME; Driver, JL; White, MD1
Oates, JC; Obeid, LM; Ruiz, P; Snider, AJ1
Antoon, JW; Beckman, BS; Chan, L; White, MD1
Bonstaff, K; Dai, L; Del Valle, L; Flemington, E; Ogretmen, B; Parsons, C; Qin, Z; Reske, T; Rodriguez, P; Senkal, C; Smith, CD; Trillo-Tinoco, J; Voelkel-Johnson, C; Wang, W1
Bendall, LJ; Bradstock, KF; Pitson, SM; Powell, JA; Tong, D; Wallington-Beddoe, CT1
Antoon, JW; Beckman, BS; Burow, ME; Gestaut, MM1
Difiglia, M; Felice, VD; Qin, T; Qin, ZH; Sapp, E; Sheng, R; Smith, CD; Waeber, C; Zhang, TT1
An, N; Cai, H; Coker, W; Costa, LJ; Garrett-Mayer, E; Gibbs, K; Kang, Y; Matson, T; Ogretmen, B; Smith, C; Song, JH; Stuart, R; Venkata, JK; Wan, Z1
Li, Z; Mei, Z; Shi, L; Shi, M; Sun, S; Wang, Y; Wang, Z; Xie, C; Yang, C; Yang, J; Zhang, S1
Keller, SN; Knudsen, KE; Schiewer, MJ; Schrecengost, RS; Smith, CD1
Bai, A; Bielawski, J; Chen, Y; Dai, L; Del Valle, L; Ochoa, AC; Parsons, C; Qin, Z; Smith, CD; Trillo-Tinoco, J1
Chen, MB; Li-Wei, W; Ning, L; Peng, X; Qi, L; Tie-Ning, Z; Xun, C; Zhi-Xiao, C1
Drake, RR; Garrett-Mayer, E; Jones, EE; Kraveka, JM; Lilly, MB; Lu, P; Rahmaniyan, M; Smith, CD; Venant, H; Voelkel-Johnson, C1
Drake, RR; Gao, P; Jones, EE; Norris, JS; Smith, CD1
Bonder, CS; Dimasi, DP; Pitson, SM1
McNaughton, M; Pitman, M; Pitson, SM; Pyne, NJ; Pyne, S1
Boakye, J; Chaiteerakij, R; Chen, G; Ding, X; Huang, S; Li, Y; Moser, CD; Ndzengue, A; Roberts, LR; Shaleh, H; Sinicrope, FA; Smith, CD; Thomas, MB; Zhou, Y; Zou, X1
Guan, S; Liu, YY; Yan, T; Zhou, J1
Lewis, CS; Smith, CD; Voelkel-Johnson, C1
Anderton, K; Bentz, TA; Brisendine, A; Britten, CD; Chin, SH; Cusack, SL; Garrett-Mayer, E; Maines, LW; Ogretmen, B; Shirai, K; Smith, CD; Thomas, MB; Zhuang, Y1
Dastmalchi, S; Hasanifard, L; Karimi, P; Rashtchizadeh, N; Samadi, N1
Dai, L; Foroozesh, M; Miele, L; Qin, Z; Smith, CD1
Chen, J; Yu, H; Zhou, J1
Bandara, G; Desai, A; Komarow, HD; Metcalfe, DD; Muñoz-Cano, R; Olivera, A; Tobío, A; Yin, Y1
Hahm, B; Seo, YJ; Studstill, CJ; Vijayan, M; Wolf, JJ; Xia, C1
Alsanafi, M; Jubair, K; Kelly, SL; McNaughton, M; Merrill, AH; Pyne, NJ; Pyne, S; Tate, RJ1
Lin, L; Mu, B; Qiao, J; Qiao, L; Shi, Y; Yan, L; Yuan, J1
Cheon, H; Dunton, W; Feith, DJ; LeBlanc, FR; Loughran, TP; Pearson, JM; Tan, SF; Xing, JC1
Cang, C; Hu, W; Qu, L; Zhang, F1
Eichmann, TO; Grbčić, P; Kraljević Pavelić, S; Sedić, M1
Fathi, R; Katz Ben-Yair, V; Keller, SN; Levitt, ML; Maines, LW; Plasse, TF; Smith, CD1

Reviews

1 review(s) available for adamantane and 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide

ArticleYear
Recent Progress in the Development of Opaganib for the Treatment of Covid-19.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Adamantane; Antiviral Agents; COVID-19 Drug Treatment; Humans; Pandemics; Pyridines; SARS-CoV-2; Sphingolipids

2022

Trials

2 trial(s) available for adamantane and 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide

ArticleYear
Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
    Blood, 2014, Sep-18, Volume: 124, Issue:12

    Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme Inhibitors; Humans; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Phosphotransferases (Alcohol Group Acceptor); Proteasome Endopeptidase Complex; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Pyridines; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Xenograft Model Antitumor Assays

2014
A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Aug-15, Volume: 23, Issue:16

    Topics: Adamantane; Adult; Aged; Dose-Response Relationship, Drug; Fatigue; Female; Humans; Male; Middle Aged; Nausea; Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Treatment Outcome; Vomiting; Young Adult

2017

Other Studies

41 other study(ies) available for adamantane and 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide

ArticleYear
Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:1

    Topics: Adamantane; Administration, Oral; Animals; Antineoplastic Agents; Apoptosis; Biological Availability; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Sprague-Dawley

2010
Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.
    Inflammopharmacology, 2010, Volume: 18, Issue:2

    Topics: Adamantane; Aminosalicylic Acids; Animals; Body Weight; Colon; Crohn Disease; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epithelial Cells; Female; Gastrointestinal Agents; Humans; Interleukin-1beta; Leukocytes; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Phosphotransferases (Alcohol Group Acceptor); Prednisolone; Pyridines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha

2010
A novel sphingosine kinase inhibitor induces autophagy in tumor cells.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:2

    Topics: Adamantane; Adenine; Animals; Apoptosis; Autophagy; Blotting, Western; Cell Cycle; Electrophoresis, Polyacrylamide Gel; Humans; Leupeptins; Mice; Mice, SCID; Microscopy, Confocal; Microtubule-Associated Proteins; Mitochondrial Membranes; Neoplasm Transplantation; Neoplasms, Experimental; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Pyridines; RNA, Small Interfering; Tumor Cells, Cultured; Unfolded Protein Response

2010
Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.
    Investigational new drugs, 2011, Volume: 29, Issue:6

    Topics: Adamantane; Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Caspase 3; Caspase 7; Catechols; Cell Line, Tumor; DNA Fragmentation; Drug Synergism; Female; Humans; Kidney Neoplasms; Mice; Mice, SCID; Niacinamide; Pancreatic Neoplasms; Phenylurea Compounds; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sorafenib; Xenograft Model Antitumor Assays

2011
Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
    Carcinogenesis, 2010, Volume: 31, Issue:10

    Topics: Adamantane; Animals; Azoxymethane; Colitis; Colon; Colonic Neoplasms; Dextran Sulfate; Extracellular Signal-Regulated MAP Kinases; Lysophospholipids; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyridines; Sphingosine

2010
Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640.
    Endocrinology, 2010, Volume: 151, Issue:11

    Topics: Adamantane; Analysis of Variance; Animals; Blotting, Western; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Estradiol; Female; Gene Expression; Humans; Immunohistochemistry; Mice; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription, Genetic

2010
Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase.
    Inflammopharmacology, 2011, Volume: 19, Issue:2

    Topics: Adamantane; Administration, Oral; Animals; Ankle; Ankle Joint; Arthritis, Experimental; Body Weight; Drug Therapy, Combination; Edema; Enzyme Inhibitors; Female; Foot; Indomethacin; Inflammation; Methotrexate; Mice; Mice, Inbred DBA; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Inbred Lew; Splenomegaly; X-Ray Microtomography

2011
Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
    Cancer biology & therapy, 2011, Mar-01, Volume: 11, Issue:5

    Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Blotting, Western; Carcinoma, Hepatocellular; Flow Cytometry; Hep G2 Cells; Humans; Liver Neoplasms; Lysophospholipids; Mice; Mitogen-Activated Protein Kinases; Niacinamide; Phenylurea Compounds; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sorafenib; Sphingosine; Xenograft Model Antitumor Assays

2011
Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
    Cancer biology & therapy, 2011, Apr-01, Volume: 11, Issue:7

    Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Mice; Mice, SCID; Molecular Targeted Therapy; NF-kappaB-Inducing Kinase; Phosphotransferases (Alcohol Group Acceptor); Protein Serine-Threonine Kinases; Pyridines; Receptors, Estrogen; Signal Transduction; Xenograft Model Antitumor Assays

2011
Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2.
    Pharmacology, 2011, Volume: 87, Issue:3-4

    Topics: Adamantane; Animals; Apoptosis; Chondrocytes; Disease Models, Animal; Iodoacetates; Male; Osteoarthritis; Pain; Pain Measurement; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Wistar

2011
Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.
    Journal of hepatology, 2012, Volume: 56, Issue:1

    Topics: Adamantane; Animals; Cell Death; Enzyme Inhibitors; Gene Knockdown Techniques; Hepatocytes; In Vitro Techniques; Inflammation; Liver; Lysophospholipids; Male; Mice; Mitochondria, Liver; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Nitric Oxide Synthase Type II; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Reperfusion Injury; RNA, Messenger; RNA, Small Interfering; Sphingosine

2012
Sphingosine kinase inhibition exerts both pro- and anti-atherogenic effects in low-density lipoprotein receptor-deficient (LDL-R(-/-)) mice.
    Thrombosis and haemostasis, 2012, Volume: 107, Issue:3

    Topics: Adamantane; Animals; Atherosclerosis; Cell Adhesion Molecules; Cell Differentiation; Cell Movement; Cell Proliferation; Cells, Cultured; Cytokines; Dendritic Cells; Disease Models, Animal; Disease Progression; Endothelium, Vascular; Enzyme Inhibitors; Humans; Inflammation Mediators; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Pyridines; Receptors, LDL; Serine Endopeptidases; T-Lymphocytes

2012
Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: Adamantane; Animals; Cell Adhesion Molecules; Chemokines; Enzyme Inhibitors; Inflammation; Leukocytes; Liver; Liver Transplantation; Lysophospholipids; Male; NF-kappa B; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Rats; Rats, Inbred Lew; Reactive Oxygen Species; Reperfusion Injury; Sphingosine; Toll-Like Receptor 4; Up-Regulation

2012
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
    Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:7

    Topics: Adamantane; Aminophenols; Animals; Antineoplastic Agents, Hormonal; Base Sequence; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Drug Resistance, Neoplasm; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoenzymes; Mice; Mice, Nude; Mice, SCID; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Thiazoles; Xenograft Model Antitumor Assays

2012
Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Adamantane; Albumins; Animals; Cell Separation; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Gene Expression Regulation, Enzymologic; Inflammation; Isoenzymes; Kidney Glomerulus; Lupus Nephritis; Mice; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Sphingolipids; Spleen; Thromboxane B2

2013
Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640.
    Anticancer research, 2013, Volume: 33, Issue:9

    Topics: Adamantane; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Ovarian Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyridines

2013
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:1

    Topics: Adamantane; Apoptosis; Cell Line, Tumor; Cell Proliferation; Herpesvirus 8, Human; Humans; Lymphoma, Primary Effusion; Lysophospholipids; Molecular Targeted Therapy; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Signal Transduction; Sphingosine

2014
Sphingosine kinase 2 promotes acute lymphoblastic leukemia by enhancing MYC expression.
    Cancer research, 2014, May-15, Volume: 74, Issue:10

    Topics: Acetylation; Adamantane; Animals; Caspases; Cell Death; Cell Growth Processes; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Genes, myc; HEK293 Cells; Histones; Humans; K562 Cells; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Phosphotransferases (Alcohol Group Acceptor); Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; Pyridines; Xenograft Model Antitumor Assays

2014
Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:1

    Topics: Adamantane; Androgen Antagonists; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Humans; Ki-67 Antigen; Male; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Pyridines

2014
Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.
    The Journal of biological chemistry, 2014, Jul-25, Volume: 289, Issue:30

    Topics: Adamantane; Anesthetics, Inhalation; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Ischemic Preconditioning; Isoflurane; Lactosylceramides; Mice; Mice, Knockout; Morpholines; Neurons; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrones; Transcription Factor TFIIH; Transcription Factors

2014
ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer.
    Cancer biology & therapy, 2015, Volume: 16, Issue:8

    Topics: Adamantane; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Protein Transport; Pyridines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

2015
Downregulation of Critical Oncogenes by the Selective SK2 Inhibitor ABC294640 Hinders Prostate Cancer Progression.
    Molecular cancer research : MCR, 2015, Volume: 13, Issue:12

    Topics: Adamantane; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Pyridines; Receptors, Androgen; Signal Transduction; Small-Conductance Calcium-Activated Potassium Channels; Xenograft Model Antitumor Assays

2015
Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression.
    Oncotarget, 2015, Sep-15, Volume: 6, Issue:27

    Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Ceramides; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Viral; Humans; Lymphoma, Primary Effusion; Lysophospholipids; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Pyridines; RNA Interference; Sphingolipids; Sphingosine; Up-Regulation

2015
Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.
    Journal of experimental & clinical cancer research : CR, 2015, Sep-04, Volume: 34

    Topics: Adamantane; Animals; Antineoplastic Agents; Cell Proliferation; Cisplatin; Colorectal Neoplasms; Female; Fluorouracil; HCT116 Cells; HT29 Cells; Humans; Male; MAP Kinase Signaling System; Mice, Nude; Middle Aged; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Xenograft Model Antitumor Assays

2015
The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
    Molecular cancer therapeutics, 2015, Volume: 14, Issue:12

    Topics: Adamantane; Animals; Apoptosis; Cell Proliferation; Ceramides; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms, Castration-Resistant; Protein Kinase Inhibitors; Pyridines; Xenograft Model Antitumor Assays

2015
Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow.
    Bioanalysis, 2015, Volume: 7, Issue:20

    Topics: Adamantane; Animals; Biomarkers, Tumor; Ceramides; Disease Models, Animal; Humans; Kidney Neoplasms; Lysophospholipids; Mice; Pancreatic Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine; Transplantation, Heterologous

2015
Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity.
    Microcirculation (New York, N.Y. : 1994), 2016, Volume: 23, Issue:3

    Topics: Adamantane; Animals; Capillary Permeability; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Pyridines

2016
Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
    Oncotarget, 2016, Mar-29, Volume: 7, Issue:13

    Topics: Adamantane; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Male; Oxidoreductases; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms, Castration-Resistant; Proteasome Endopeptidase Complex; Pyridines; Thiazoles

2016
Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.
    Oncotarget, 2016, Apr-12, Volume: 7, Issue:15

    Topics: Adamantane; Apoptosis; Autophagy; Bile Duct Neoplasms; Cell Proliferation; Cholangiocarcinoma; Drug Synergism; Drug Therapy, Combination; Humans; Niacinamide; Phenylurea Compounds; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyridines; Sorafenib; Tumor Cells, Cultured

2016
Inhibition of ceramide glucosylation sensitizes lung cancer cells to ABC294640, a first-in-class small molecule SphK2 inhibitor.
    Biochemical and biophysical research communications, 2016, 08-05, Volume: 476, Issue:4

    Topics: A549 Cells; Adamantane; Antineoplastic Agents; Apoptosis; Cell Proliferation; Ceramides; Drug Resistance, Neoplasm; Glucosyltransferases; Humans; Lung; Lung Neoplasms; Phosphotransferases (Alcohol Group Acceptor); Pyridines

2016
Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.
    Oncotarget, 2016, Sep-13, Volume: 7, Issue:37

    Topics: Acetylation; Adamantane; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Synergism; Gemcitabine; Gene Expression Regulation, Neoplastic; Histones; Humans; Pancreatic Neoplasms; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-myc; Pyridines; Retinoblastoma Protein; Ribonucleoside Diphosphate Reductase

2016
Sphingosine kinase-2 Inhibitor ABC294640 Enhances Doxorubicin-Induced Apoptosis of NSCLC Cells via Altering Survivin Expression.
    Drug research, 2018, Volume: 68, Issue:1

    Topics: A549 Cells; Adamantane; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Survival; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyridines; Survivin; Tetradecanoylphorbol Acetate

2018
The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.
    International journal of cancer, 2018, 05-15, Volume: 142, Issue:10

    Topics: A549 Cells; Adamantane; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Growth Processes; Ceramides; Humans; Lung Neoplasms; Mice; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyridines; Random Allocation; Xenograft Model Antitumor Assays

2018
Targeting sphingosine kinase 2 by ABC294640 inhibits human skin squamous cell carcinoma cell growth.
    Biochemical and biophysical research communications, 2018, 03-04, Volume: 497, Issue:2

    Topics: Adamantane; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Male; Mice, Nude; Molecular Targeted Therapy; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Skin Neoplasms

2018
Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Adamantane; Animals; Apoptosis; Carcinogenesis; Cell Proliferation; Cell Survival; DNA Repair; Hematologic Neoplasms; Humans; Hydrazines; Mast Cells; Mastocytosis; Mice; Mice, Knockout; Mutation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Proto-Oncogene Proteins c-kit; Pyrazoles; Pyridines; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2018
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
    Antiviral research, 2018, Volume: 158

    Topics: A549 Cells; Adamantane; Administration, Oral; Amino Alcohols; Aminophenols; Animals; Cell Line; Disease Models, Animal; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Pyridines; RNA, Small Interfering; Sphingosine; Thiazoles; Virus Replication

2018
Native and Polyubiquitinated Forms of Dihydroceramide Desaturase Are Differentially Linked to Human Embryonic Kidney Cell Survival.
    Molecular and cellular biology, 2018, 12-01, Volume: 38, Issue:23

    Topics: Adamantane; Apoptosis; Cell Line; Cell Survival; Fatty Acid Desaturases; HEK293 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Kidney; Oxidoreductases; p38 Mitogen-Activated Protein Kinases; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Pyridines; Sphingosine; Ubiquitin-Protein Ligases; Ubiquitination; X-Box Binding Protein 1

2018
Inhibition of SphK2 Stimulated Hepatic Gluconeogenesis Associated with Dephosphorylation and Deacetylation of STAT3.
    Archives of medical research, 2018, Volume: 49, Issue:5

    Topics: Acetylation; Adamantane; Animals; Cells, Cultured; Gluconeogenesis; Glucose; Humans; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Processing, Post-Translational; Pyridines; RNA, Small Interfering; STAT3 Transcription Factor; Up-Regulation

2018
Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1.
    British journal of haematology, 2020, Volume: 190, Issue:3

    Topics: Adamantane; Adult; Aged; Apoptosis; Enzyme Induction; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Large Granular Lymphocytic; Leukocytes, Mononuclear; Lysophospholipids; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Peptide Fragments; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proteasome Endopeptidase Complex; Proto-Oncogene Proteins; Pyridines; RNA Interference; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Sphingosine; Thiazolidinediones; Up-Regulation

2020
Sphingosine kinase 2 inhibitor ABC294640 suppresses neuronal excitability and inhibits multiple endogenously and exogenously expressed voltage-gated ion channels in cultured cells.
    Channels (Austin, Tex.), 2020, Volume: 14, Issue:1

    Topics: Action Potentials; Adamantane; Cell Line, Tumor; Electrophysiology; HEK293 Cells; Hippocampus; Humans; Kv1.4 Potassium Channel; Neurons; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Shal Potassium Channels; Thiazolidinediones

2020
The Sphingosine Kinase 2 Inhibitor ABC294640 Restores the Sensitivity of BRAFV600E Mutant Colon Cancer Cells to Vemurafenib by Reducing AKT-Mediated Expression of Nucleophosmin and Translationally-Controlled Tumour Protein.
    International journal of molecular sciences, 2021, Oct-05, Volume: 22, Issue:19

    Topics: Adamantane; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Nuclear Proteins; Nucleophosmin; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Pyridines; Tumor Cells, Cultured; Tumor Protein, Translationally-Controlled 1; Vemurafenib

2021