Compounds > adamantane
Page last updated: 2024-08-21

adamantane and 1,2,4-trioxane

adamantane has been researched along with 1,2,4-trioxane in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Alker, A; Charman, SA; Charman, WN; Chiu, FC; Dong, Y; Hunziker, D; Morizzi, J; Ruf, A; Scheurer, C; Vennerstrom, JL; Wang, X; Wittlin, S; Zhou, L1
Arbe-Barnes, S; Bathurst, IC; Brun, R; Campbell, M; Charman, SA; Charman, WN; Chiu, FC; Chollet, J; Craft, JC; Creek, DJ; Dong, Y; Matile, H; Maurer, M; Morizzi, J; Nguyen, T; Papastogiannidis, P; Scheurer, C; Shackleford, DM; Sriraghavan, K; Stingelin, L; Tang, Y; Urwyler, H; Vennerstrom, JL; Wang, X; White, KL; Wittlin, S; Zhou, L1
Charman, SA; Chiu, FC; Chollet, J; Dong, Y; Katneni, K; Mannila, J; Morizzi, J; Ryan, E; Santo Tomas, J; Scheurer, C; Snyder, C; Steuten, J; Vennerstrom, JL; Wang, X; Wittlin, S1
Charman, SA; Creek, DJ; Giannangelo, C; Stingelin, L; Tilley, L; Yang, T1
Anderson, BM; Charman, SA; Creek, DJ; De Paoli, A; Edgington-Mitchell, LE; Giannangelo, C; Siddiqui, G1

Other Studies

5 other study(ies) available for adamantane and 1,2,4-trioxane

ArticleYear
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277.
    Bioorganic & medicinal chemistry letters, 2008, Mar-01, Volume: 18, Issue:5

    Topics: Adamantane; Antimalarials; Cytochrome P-450 Enzyme System; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Humans; Microsomes, Liver; Molecular Structure; Peroxides; Spiro Compounds

2008
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Mar-15, Volume: 108, Issue:11

    Topics: Adamantane; Animals; Antimalarials; Artemisinins; Dose-Response Relationship, Drug; Drug Stability; Heterocyclic Compounds; Iron; Malaria; Male; Mice; Peroxides; Plasmodium berghei; Rats; Rats, Sprague-Dawley; Time Factors; Treatment Outcome

2011
Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: Absorption; Adamantane; Animals; Antimalarials; Dioxolanes; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Male; Mice; Peroxides; Plasmodium berghei; Plasmodium falciparum; Spiro Compounds; Structure-Activity Relationship; Tetraoxanes

2013
Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts
    Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:3

    Topics: Adamantane; Antimalarials; Erythrocytes; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Humans; Peroxides; Plasmodium falciparum; Spiro Compounds; Trophozoites

2018
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.
    PLoS pathogens, 2020, Volume: 16, Issue:6

    Topics: Adamantane; Antimalarials; Erythrocytes; Hemoglobins; Heterocyclic Compounds; Heterocyclic Compounds, 1-Ring; Humans; Peroxides; Plasmodium falciparum; Proteomics; Spiro Compounds

2020