acyclovir and lupeol
acyclovir has been researched along with lupeol* in 1 studies
Other Studies
1 other study(ies) available for acyclovir and lupeol
| Article | Year |
|---|---|
Lupeol impairs herpes simplex virus type 1 replication by inhibiting the promoter activity of the viral immediate early gene α0.
Herpes simplex virus type 1 (HSV-1) is an important human pathogenic virus. It is urgent to develop novel antiviral targets because of the limited treatment options and the emergence of drug resistant strains. In this study, we tested the antiviral activity of lupeol, a triterpenoid compound, against HSV-1 and acyclovir (ACV) resistant strains. Lupeol significantly inhibited HSV-1 (F strain) and ACV-resistant strains including HSV-1/106, HSV-1/153, and HSV-1/Blue. Lupeol activity of the HSV-1α0 and α4 promoters, therefore down regulating the expression of the α0, α4, and α27 genes. Collectively, lupeol showed strong antiviral activity against HSV-1 and ACV-resistant strains, and could be a promising therapeutic candidate for HSV-1 pathogenesis. Keywords: herpes simplex virus 1; lupeol; ACV-resistant strains; promoter. Topics: Acyclovir; Antiviral Agents; Drug Resistance, Viral; Genes, Immediate-Early; Herpes Simplex; Herpesvirus 1, Human; Humans; Pentacyclic Triterpenes | 2021 |