acyclovir and betulin
acyclovir has been researched along with betulin* in 2 studies
Other Studies
2 other study(ies) available for acyclovir and betulin
| Article | Year |
|---|---|
Novel betulin dicarboxylic acid ester derivatives as potent antiviral agents: Design, synthesis, biological evaluation, structure-activity relationship and in-silico study.
Topics: Antiviral Agents; Dicarboxylic Acids; DNA Viruses; Dose-Response Relationship, Drug; Drug Design; Esters; Microbial Sensitivity Tests; Molecular Structure; RNA Viruses; Structure-Activity Relationship; Triterpenes | 2021 |
The synergistic effects of betulin with acyclovir against herpes simplex viruses.
Betulin, a pentacyclic triterpenoid, was isolated from the bark of Betula papyrifera. The antiviral efficacies of betulin on herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) were evaluated using viral plaque reduction assays on Vero cells. The results indicate that betulin is active against both HSV-1 and HSV-2 infections with the 50% effective concentrations (EC(50)) of 0.40 and 4.15 microg/ml, respectively. The cytotoxicity of betulin was examined on Vero cells using a neutral red uptake assay. The 50% cytotoxic concentration (CC(50)) of betulin was 73.1 microg/ml. A synergistic antiviral effect between betulin and acyclovir (ACV) was determined by drug combination studies. Strong and moderate synergistic antiviral effects were observed for betulin and ACV against HSV-1 when the concentrations of ACV and betulin were higher than 0.068 and 0.4 microg/ml, respectively. At the concentrations lower than these, additive effect was found. Synergistic antiviral effects were also found against HSV-2 at higher concentrations than for HSV-1, i.e. 0.45 microg/ml of ACV combined with 8.4 microg/ml of betulin. Topics: Acyclovir; Animals; Antiviral Agents; Chlorocebus aethiops; Drug Synergism; Drug Therapy, Combination; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Triterpenes; Vero Cells; Viral Plaque Assay | 2004 |