acyclovir and aluminum-hydroxide--magnesium-hydroxide--drug-combination

To review the treatment of primary herpetic gingivostomatitis at a children's hospital.. A review of charts from 1999 to 2003.. Forty-eight cases were identified. They ranged in age from 8 months to 12 years, with a median age of 2 years 7 months. All children were treated with fluids and analgesics; 11 children were treated with fluids and analgesics exclusively. Thirty-five children were treated with a mixture of Maalox and diphenhydramine, 8 with acyclovir, and 7 with viscous lidocaine; 11 children were treated with 2 or more of these regimens. Both the Maalox and diphenhydramine mixture and the viscous lidocaine were administered as swish and swallow, swish and spit, or by application with a swab as frequently as every hour or as infrequently as every 8 hours.. Topical therapy with Maalox and diphenhydramine or viscous lidocaine was administered to 73% and 15% of the patients, respectively, whereas acyclovir was administered to only 17%. Dosing and administration of topical agents in the treatment of primary herpetic gingivostomatitis in preschoolers were problematic. Acyclovir was not being used as often as it could have been.

Topics: Acyclovir; Administration, Oral; Aluminum Hydroxide; Analgesics; Anesthetics, Local; Antacids; Antiviral Agents; Child; Child, Preschool; Diphenhydramine; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Fluid Therapy; Humans; Incidence; Infant; Lidocaine; Magnesium Hydroxide; Male; New York; Stomatitis, Herpetic

Valaciclovir is rapidly and extensively converted to acyclovir. In this study we investigated the potential interaction between oral valaciclovir and Maalox. On each of three occasions 18 healthy volunteers received a single oral dose of 1000 mg valaciclovir, or 30 mL Maalox 65 min after valaciclovir administration, or 30 mL Maalox 30 min before valaciclovir. Acyclovir plasma concentrations and pharmacokinetic parameters were not significantly affected by administration of Maalox before or after valaciclovir. Therefore, there is no need for restriction of valaciclovir dosing in patients receiving antacid medication.

Topics: Acyclovir; Adult; Aluminum Hydroxide; Analysis of Variance; Antacids; Antiviral Agents; Drug Combinations; Drug Interactions; Female; Humans; Magnesium Hydroxide; Male; Prodrugs; Reference Values; Valacyclovir; Valine