acyclovir has been researched along with 2-aminobenzimidazole* in 1 studies
1 other study(ies) available for acyclovir and 2-aminobenzimidazole
| Article | Year |
|---|---|
New modified 2-aminobenzimidazole nucleosides: Synthesis and evaluation of their activity against herpes simplex virus type 1.
Using the enzymatic transglycosylation reaction β-d-ribo- and 2'-deoxyribofuranosides of 2-amino-5,6-difluorobenzimidazole nucleosides have been synthesized. 2-Amino-5,6-difluoro-benzimidazole riboside proved to exhibit a selective antiviral activity (selectivity index >32) against a wild strain of the herpes simplex virus type 1, as well as towards virus strains that are resistant to acyclovir, cidofovir, and foscarnet. We believe that this compound might be used for treatment of herpes infections in those cases, when acyclovir is not efficient. Topics: Acyclovir; Antiviral Agents; Benzimidazoles; Cidofovir; Cytosine; Drug Resistance, Viral; Foscarnet; Herpesvirus 1, Human; Humans; Nucleosides; Organophosphonates | 2017 |