acyclovir and 2-3-dihydroxyquinoxaline

acyclovir has been researched along with 2-3-dihydroxyquinoxaline* in 1 studies

Other Studies

1 other study(ies) available for acyclovir and 2-3-dihydroxyquinoxaline

Article	Year
2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase. FEBS letters, 2014, Jan-31, Volume: 588, Issue:3 2,3-Dihydroxy-quinoxaline, a small molecule that promotes ATPase catalytic activity of Herpes Simplex Virus thymidine kinase (HSV-TK), was identified by virtual screening. This compound competitively inhibited HSV-TK catalyzed phosphorylation of acyclovir with Ki=250 μM (95% CI: 106-405 μM) and dose-dependently increased the rate of the ATP hydrolysis with KM=112 μM (95% CI: 28-195 μM). The kinetic scheme consistent with this experimental data is proposed. Topics: Acyclovir; Adenosine Triphosphatases; Catalysis; Humans; Kinetics; Phosphorylation; Quinoxalines; Simplexvirus; Thymidine Kinase	2014

Article

Year

2,3-Dihydroxy-quinoxaline induces ATPase activity of Herpes Simplex Virus thymidine kinase.

FEBS letters, 2014, Jan-31, Volume: 588, Issue:3

2,3-Dihydroxy-quinoxaline, a small molecule that promotes ATPase catalytic activity of Herpes Simplex Virus thymidine kinase (HSV-TK), was identified by virtual screening. This compound competitively inhibited HSV-TK catalyzed phosphorylation of acyclovir with Ki=250 μM (95% CI: 106-405 μM) and dose-dependently increased the rate of the ATP hydrolysis with KM=112 μM (95% CI: 28-195 μM). The kinetic scheme consistent with this experimental data is proposed.

Topics: Acyclovir; Adenosine Triphosphatases; Catalysis; Humans; Kinetics; Phosphorylation; Quinoxalines; Simplexvirus; Thymidine Kinase

2014