acyclovir and 10-carboxymethyl-9-acridanone

The treatment of patients with various forms of herpes requires a complex approach with using chemo- and immunotropic drugs. The use of Cycloferon, an interferon inductor (12.5% injection solution, 150 mg tablets or 5% liniment) was shown efficient. It had antiviral and immunotropic action in the mono- and combination therapy of herpes simplex of the skin and mucosa, genital herpes, ophthalmoherpes, herpes zoster, infectious mononucleosis. Cycloferon lowered the level and period of the disease clinical signs, prolonged the remission, corrected the immunity shifts, prevented the complications. The results of the study presented a conclusive proof for recommending such a use of Cycloferon in wide medical practice.

Topics: Acridines; Acyclovir; Antiviral Agents; Female; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Herpesviridae; Humans; Immunity, Innate; Infectious Mononucleosis; Interferon Inducers; Keratitis, Herpetic; Male

The aim of the study was to estimate the efficacy of liniment cycloferon included in combined therapy of herpetic infection in 30 patients with psoriasis divided into 2 groups. Combined treatment of patients with recurrent herpetic infection promoted elimination of general infection syndrome, shortened duration of eruption and local inflammation, accelerated epithelization of herpetic erosion, and decreased the frequency of relapses during the follow-up.

Topics: Acridines; Acyclovir; Adult; Anti-Infective Agents, Local; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Female; Herpesviridae Infections; Herpesvirus 1, Human; Humans; Immunomodulation; Interferon Inducers; Liniments; Male; Psoriasis; Re-Epithelialization; Recurrence; Treatment Outcome

In order to determine the anti-pathogenic clinical efficacy of cycloferon liniment in the combined treatment of herpetic stomatitis and periodontitis, medical examination and treatment of these disorders have been carried out in a group of 80 patients. It is established that the use of cycloferon liniment in the combined treatment of herpetic stomatitis and periodontitis decreases the infectious load in parodontal recess, reduces the manifestations of local inflammation, normalizes the immunity indices, and decreases the level of endogenous intoxication, which ensures the acceleration of recuperation processes and lowers the frequency of recurrences.

Topics: Acridines; Acyclovir; Adult; Candida albicans; Chlamydia trachomatis; Female; Humans; Immunoassay; Immunoglobulin A; Inflammation; Interferon Inducers; Interleukin-1beta; Liniments; Male; Mouth; Periodontitis; Recurrence; Severity of Illness Index; Simplexvirus; Stomatitis, Herpetic; Tumor Necrosis Factor-alpha

Up-to-date conceptions of etiology and epidemiology of anogenital herpetic infection are described. The main mechanisms of immunological shifts in subjects with anogenital Herpes infection are discussed. The efficacy and safety of cycloferon in the combined treatment of patients with recurring anogenital herptic infection were estimated. The clinical efficacy of the combined therapy (acyclovir in a dose of 200 mg 5 times a day for 5 days + cycloferon liniment applied topically on the eruptions twice a day for 5 days) was 85% or 25% higher vs. the control.

Topics: Acridines; Acyclovir; Administration, Topical; Antiviral Agents; Herpes Genitalis; Herpes Simplex; Humans; Recurrence; Sexually Transmitted Diseases; Time Factors