activins has been researched along with transforming growth factor beta in 652 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 152 (23.31) | 18.2507 |
| 2000's | 289 (44.33) | 29.6817 |
| 2010's | 166 (25.46) | 24.3611 |
| 2020's | 45 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Bachvarova, RF; Manova, K; Paynton, BV | 1 |
| Armstrong, RM; de Leon, ER; Erickson, KL; Miller, KL; Nathan, RM; Ogawa, Y; Rosen, DM; Sawamura, SJ; Schmidt, DK; Ziman, JM | 1 |
| Robertson, DM | 1 |
| Bilezikjian, LM; Corrigan, AZ; González-Manchón, C; Mellon, PL; Vale, W | 1 |
| Canalis, E; Centrella, M; McCarthy, TL | 1 |
| Honma, Y; Hozumi, M; Okabe-Kado, J | 1 |
| Murata, T; Ying, SY | 1 |
| Baird, A; Brown, MR; Jimenez, LL; Vale, W; Vaughan, J | 1 |
| Lyons, KM | 1 |
| Ramsdell, JS | 1 |
| Frigon, NL; Maderazo, L; Shao, LE; Vale, W; Vaughan, J; Yu, A; Yu, J | 1 |
| Baird, A; Brown, MR; Hexum, TD; Jimenez, L; Vale, W; Vaughan, J; Walsh, J | 1 |
| Blumberg, BW; Cho, KW; Hashimoto, C; Hawley, SH; Laurent, MN; Watabe, T; Wünnenberg-Stapleton, K | 1 |
| D'Alessandro, JS; Wang, EA; Yetz-Aldape, J | 1 |
| Benahmed, M; Le Magueresse-Battistoni, B; Morera, AM | 1 |
| Harland, RM; McKendry, R; Ribisi, S; Smith, WC | 1 |
| Kojima, T; Mitaka, T; Mochizuki, Y; Norioka, K | 1 |
| Johnson, RL; Kuehn, M; Levin, M; Stern, CD; Tabin, C | 1 |
| Blok, LJ; de Jong, FH; de Winter, JP; Themmen, AP; Timmerman, MA; Vanderstichele, HM | 1 |
| Gaddy-Kurten, D; Tsuchida, K; Vale, W | 1 |
| Minoura, I; Nakamura, H; Shiokawa, K; Tashiro, K | 1 |
| Andries, M; Heldin, CH; Huylebroeck, D; Miyazono, K; Sampath, TK; Smith, JC; ten Dijke, P; Yamashita, H | 1 |
| Antonipillai, I; Horton, R; Wahe, M; Yamamoto, J | 1 |
| Lin, HY; Lodish, HF; Moustakas, A; Takumi, T | 1 |
| Franzén, P; Heldin, CH; Miyazono, K; Okadome, T; ten Dijke, P; Yamashita, H | 1 |
| H tten, G; Neidhardt, H; Pohl, J; Schneider, C | 1 |
| D'Alessandro, JS; Wang, EA | 1 |
| Fischer, WH; Krieglstein, K; Suter-Crazzolara, C; Unsicker, K | 1 |
| Bickenbach, JR; Bradley, A; Jaenisch, R; Kumar, TR; Matzuk, MM; Roop, DR; Vassalli, A | 1 |
| Benahmed, M; Goddard, I | 1 |
| Gougeon, A | 1 |
| Estevez, M; Heldin, CH; Ichijo, H; Miyazono, K; Reddi, AH; Riddle, DL; Sampath, TK; ten Dijke, P; Yamashita, H | 1 |
| Dale, L; Schulte-Merker, S; Smith, JC | 1 |
| Coskun, S; Lin, YC | 1 |
| Franzén, P; Heldin, CH; Ichijo, H; Laiho, M; Miyazono, K; ten Dijke, P; Yamashita, H | 1 |
| Centrella, M; Horowitz, MC; McCarthy, TL; Wozney, JM | 1 |
| Briers, TW; van de Voorde, A; Vanderstichele, H | 1 |
| Attisano, L; Cárcamo, J; Massagué, J; Ventura, F; Weis, FM; Wieser, R; Wrana, JL | 1 |
| Bhushan, A; Kintner, CR; Lin, HY; Lodish, HF | 1 |
| Bicknell, R; McCarthy, SA | 1 |
| Chen, RH; Derynck, R; Ebner, R; Lawler, S; Zioncheck, T | 1 |
| Attisano, L; Cárcamo, J; Massagué, J; Ventura, F; Weis, FM; Wrana, JL | 1 |
| Nishihara, T; Okahashi, N; Ueda, N | 1 |
| Chen, P; Luyten, FP; Paralkar, V; Reddi, AH | 1 |
| Chang, L; Jardieu, P; Lai, C; Robbins, K; Schwall, RH; Terrell, TG | 1 |
| Feijen, A; Huylebroeck, D; van den Eijnden-van Raaij, AJ; van der Kruijssen, CM | 1 |
| Asano, S; Eto, Y; Hasegawa, Y; Kojima, I; Mine, T; Shibata, H; Takeuchi, T; Yasuda, H | 1 |
| Mummery, CL; van den Eijnden-van Raaij, AJ | 1 |
| Kan, M; Krummen, L; Matsuzaki, K; McKeehan, WL; Wang, F; Xu, J | 1 |
| Clarke, L; Hedger, MP | 1 |
| Hakovirta, H; Kaipia, A; Parvinen, M; Söder, O | 1 |
| Qu, J; Thomas, K | 1 |
| de Winter, JP; Kalkhoven, E; Mummery, CL; Roelen, BA; van den Eijnden-van Raaij, AJ; van der Burg, B; van der Saag, PT | 1 |
| Ritvos, O; Tuuri, T | 1 |
| Fransen, ME; Lemanski, LF; Mangiacapra, FJ | 1 |
| Danielson, PD; Donahoe, PK; Kim, SD; Li, BY; Shah, PC; Wang, T | 1 |
| Erämaa, M; Ritvos, O | 1 |
| Alexander, JM; Bikkal, HA; Klibanski, A; Laws, ER; Zervas, NT | 1 |
| Abdollah, S; Attisano, L; Haerry, T; Hoodless, PA; O'Connor, MB; Stapleton, M; Wrana, JL | 1 |
| Avallet, O; Chuzel, F; Durand, P; Habert, R; Lejeune, H; Saez, J; Thomas, T | 1 |
| Melton, DA; Reilly, KM | 1 |
| Huang, HC; Murtaugh, LC; Vize, PD; Whitman, M | 1 |
| Chen, X; Rubock, MJ; Whitman, M | 1 |
| Hata, A; Hemmati-Brivanlou, A; Lagna, G; Massagué, J | 1 |
| Aydelotte, MB; Davies, SR; Flechtenmacher, J; Huch, K; Kuettner, KE; Mollenhauer, JA; Puhl, W; Sampath, TK; Schmid, TM; Thonar, EJ | 1 |
| France, JT; Keelan, J; Song, Y | 1 |
| Chen, Y; Lebrun, JJ; Vale, W | 1 |
| Holmes, LB; Levin, M; Roberts, DJ; Tabin, C | 1 |
| Armes, N; Jones, CM; Smith, JC | 1 |
| Bradshaw, D; Dalkin, AC; Gilrain, JT; Myers, CE | 1 |
| Bonadio, J; Fang, J; Smiley, E; Wang, SQ; Yin, W | 1 |
| Hitomi, K; Torii, Y; Tsukagoshi, N | 1 |
| Clement, JH; Friedle, H; Kaufmann, E; Knöchel, W; Metz, A; Paul, H; Scheucher, M | 1 |
| Dyson, S; Gurdon, JB | 1 |
| Jaffe, RB; Mesiano, S | 1 |
| Lebrun, JJ; Vale, WW | 1 |
| Fagotto, F; Guger, K; Gumbiner, BM | 1 |
| Ford, JJ; Howard, HJ | 1 |
| Gilbert, SF | 1 |
| de Winter, JP; Roelen, BA; ten Dijke, P; van den Eijnden-van Raaij, AJ; van der Burg, B | 1 |
| Kessler, JA; Mabie, PC; Marmur, R; Mehler, MF; Papavasiliou, A; Song, Q | 1 |
| Horb, ME; Thomsen, GH | 1 |
| Kanzaki, M; Kojima, I; Mashima, H; Shibata, H; Zhang, YQ | 1 |
| Link, BA; Nishi, R | 1 |
| de Jong, FH; de Winter, JP; Martens, JW; McLuskey, A; Themmen, AP; Timmerman, MA; van Schaik, RH | 1 |
| Kato, M; Miyazono, K; Saeki, K; Takaku, F; Yazaki, Y; Yuo, A | 1 |
| Caniggia, I; Cross, JC; Lye, SJ | 1 |
| Crease, DJ; Gurdon, JB; McDowell, N; Zorn, AM | 1 |
| Akamine, A; Kuhara, S; Nakashima, M; Toyono, T | 1 |
| Jessell, TM; Liem, KF; Tremml, G | 1 |
| Aubin, JE; Harada, S; Rodan, GA; Sampath, TK | 1 |
| Liu, F; Massagué, J; Pouponnot, C | 1 |
| Candia, AF; Cho, KW; Derynck, R; Hawley, SH; Niehrs, C; Onichtchouk, D; Watabe, T; Zhang, Y | 1 |
| Kanzaki, M; Kojima, I; Shibata, H; Zhang, YQ | 1 |
| Aghdasi, B; Armstrong, DL; Bao, S; Charng, MJ; Guo, Q; Hamilton, SL; Mathews, LM; Matzuk, MM; Schneider, MD; Shou, W | 1 |
| Buckhaults, P; Bunz, F; Dai, JL; Kern, SE; Kinzler, KW; Riggins, G; Vogelstein, B; Zawel, L; Zhou, S | 1 |
| Asakura, H; Ichida, T; Ishikawa, T; Matsuda, Y; Sato, T; Sugiyama, M | 1 |
| Hagiwara, K; Hanyu, A; Miyazono, K; Mogi, A; Nagamachi, Y; Nagashima, M; Takenoshita, S; Yagi, K; Yang, K | 1 |
| Hyatt, BA; Yost, HJ | 1 |
| de Kretser, DM; Hedger, MP; Hutchinson, P; Tompkins, AB | 1 |
| Nishimori, K | 1 |
| Dolter, KE; Shao, LE; Yu, EW; Yu, J | 1 |
| Aoki, T; Hirono, I; Tada, T; Takashima, F | 1 |
| Heldin, CH; Imamura, T; Kato, M; Kawabata, M; Miyazono, K; Nakao, A; Shimada, S; Shimizu, A; ten Dijke, P | 1 |
| Dennler, S; Gauthier, JM; Huet, S; Itoh, S; ten Dijke, P; Vivien, D | 1 |
| Nishimatsu, S; Thomsen, GH | 1 |
| Economides, AN; Eimon, PM; Harland, RM; Hsu, DR; Wang, X | 1 |
| Heldin, CH; Itoh, S; Jonk, LJ; Kruijer, W; ten Dijke, P | 1 |
| Attisano, L; Hoodless, PA; Labbé, E; Silvestri, C; Wrana, JL | 1 |
| Kinzler, KW; Lengauer, C; Vogelstein, B; Zawel, L; Zhou, S | 1 |
| Afrakhte, M; Heldin, CH; Heldin, NE; Itoh, S; Jossan, S; Morén, A; Sampath, K; ten Dijke, P; Westermark, B | 1 |
| Ishisaki, A; Nakao, A; Nishihara, T; Nonaka, K; Ohguchi, M; ten Dijke, P; Yamato, K | 1 |
| Berg, LK; Christian, JL; Gardner, H; Nakayama, T | 1 |
| Gurdon, JB; Mahony, D; Massagué, J; Weis, FM | 1 |
| Buchwald, M; Hoodless, PA; Macías-Silva, M; Tang, SJ; Wrana, JL | 1 |
| Akamine, A; Murakami, T; Nakashima, M; Toyono, T | 1 |
| Danos, MC; Groth, TW; Lohr, JL; Yost, HJ | 1 |
| Thisse, B; Thisse, C | 1 |
| Dou, CL; Lai, E; Liu, B; Prabhu, L | 1 |
| Barbara, NP; Letarte, M; Wrana, JL | 1 |
| Antin, PB; Ladd, AN; Yatskievych, TA | 1 |
| Blum, M; Campione, M; Deissler, K; Haffter, P; Kuehn, MR; Lowe, LA; Nowotschin, S; Schweickert, A; Steinbeisser, H; van Bebber, F; Viebahn, C | 1 |
| Attisano, L; Hoodless, PA; Nishimatsu, S; Thomsen, GH; Tsukazaki, T; Wrana, JL | 1 |
| Enders, GC; Resnick, JL; Richards, AJ | 1 |
| Jaffe, RB; Lee, JY; Mesiano, S; Spencer, SJ | 1 |
| Attisano, L; Lux, A; Marchuk, DA | 1 |
| Economides, AN; Gañan, Y; Hurle, JM; Izpisua-Belmonte, JC; Macias, D; Merino, R; Rodriguez-Esteban, C; Rodriguez-Leon, J | 1 |
| Hashimoto, S; Ishisaki, A; Nakao, A; Nishihara, T; Nonaka, K; Sugino, H; Tamaki, K; ten Dijke, P; Yamato, K | 1 |
| Baker, JC; Beppu, H; Das, P; Harland, RM; Inoue, H; Kawabata, M; Miyazono, K; Padgett, RW | 1 |
| Koide, M; Murase, Y; Nishihara, T; Noguchi, T; Okahashi, N; Yamato, K | 1 |
| Abe, Y; Andoh, K; Ibuki, Y; Kobayashi, J; Liu, X; Mizunuma, H; Yamada, K | 1 |
| Izpisúa Belmonte, JC | 1 |
| Huhtaniemi, I; Rahman, NA | 1 |
| Broadbent, J; Holder, N; Koshida, S; Patient, R; Price, B; Rodaway, A; Smith, JC; Takeda, H | 1 |
| Osada, SI; Wright, CV | 1 |
| Elvin, JA; Matzuk, MM; Nishimori, K; Wang, P; Yan, C | 1 |
| Ichikawa, Y; Ishikawa, T; Lebrun, JJ; Mitsuhashi, M; Momiyama, N; Nagashima, Y; Shimada, H; Takabe, K; Vale, WW | 1 |
| Afrakhte, M; Heldin, CH; Piek, E; Sampath, K; ten Dijke, P; van Zoelen, EJ | 1 |
| Moody, SA; Moore, KB | 1 |
| Brown, MC; Molloy, CJ; Riedy, MC; Turner, CE | 1 |
| Erämaa, M; Hildén, K; Ritvos, O; Tuuri, T | 1 |
| Franzén, A; Heldin, NE; Piek, E; ten Dijke, P; Westermark, B | 1 |
| Brown, NA; King, T | 1 |
| Clements, D; Friday, RV; Woodland, HR | 1 |
| Chen, YG; Delius, H; Dosch, R; Gawantka, V; Massagué, J; Niehrs, C; Onichtchouk, D | 1 |
| Hill, CS; Howell, M; Itoh, F; Itoh, S; Pierreux, CE; ten Dijke, P; Valgeirsdottir, S | 1 |
| Chen, Y; Liu, J; Nagarajan, RP | 1 |
| Chen, Y; Li, W; Nagarajan, RP; Zhang, J | 1 |
| Heldin, CH; Kurisaki, A; Moustakas, A; Piek, E; ten Dijke, P | 1 |
| Hoodless, PA; Itié, A; Kim, S; Mak, TW; Maxson, R; Mirtsos, C; Sirard, C; Tadich, P; Wrana, JL | 1 |
| Chang, C; Hemmati-Brivanlou, A | 1 |
| Ai, X; Cappuzzello, J; Hall, AK | 1 |
| Thisse, B; Thisse, C; Wright, CV | 1 |
| Inoue, H; Ishidou, Y; Kawabata, M; Kusanagi, K; Mishima, HK; Miyazono, K | 1 |
| Esslemont, GM; Germain, S; Hill, CS; Howell, M | 1 |
| Conover, J; Coulombe, J; Kos, K; Pitts, RL; Symes, AJ | 1 |
| Kogure, K; Kojima, I; Kuwano, H; Maeshima, A; Suzuki, K; Zhang, YQ | 1 |
| Adachi, H; Frisch, A; Hamada, H; Osada, SI; Saijoh, Y; Watanabe, M; Whitman, M; Wright, CV; Yeo, CY | 1 |
| Bronner-Fraser, M; García-Castro, MI; Vielmetter, E | 1 |
| de Kretser, DM; Hedger, MP; Phillips, DJ | 1 |
| Beauvillain, JC; Bouret, S; Croix, D; Jennes, L; Mitchell, V; Prevot, V; Takumi, T | 1 |
| Beddington, R; Ellis, S; Lee, A; Placzek, M; Szabo, M; Thomas, P; Vesque, C | 1 |
| Hefferan, TE; Khosla, S; Riggs, BL; Spelsberg, TC; Subramaniam, M | 1 |
| Demetris, AJ; Ezure, T; Lunz, JG; Murase, N; Sakamoto, T; Tsuji, H; Yokomuro, S | 1 |
| Mattson, MP | 1 |
| Killefer, J; Kirkpatrick-Keller, DC; Kocamis, H; Richter, J | 1 |
| Demay, MB; Kearns, AE | 1 |
| Breit, S; Fotsis, T; Rössler, J; Schweigerer, L | 1 |
| Dou, C; Lai, E; Lee, J; Liu, B; Liu, F; Massague, J; Xuan, S | 1 |
| Farnworth, PG; Hertan, R; Robertson, DM | 1 |
| Arai, KY; Hasegawa, Y; Kuramoto, Y; Sugino, H; Tsuchida, K; Yamakawa, N | 1 |
| Furukawa, M; Kojima, I; Maeshima, A; Naruse, T; Zhang, YQ | 1 |
| Beppu, H; Miyazono, K | 1 |
| Celeste, AJ; Kuehn, MR; Kumar, A; Novoselov, V; ten Dijke, P; Wolfman, NM | 1 |
| Hausen, P; Kurth, T | 1 |
| Asashima, M; Takahashi, S; Tanegashima, K; Yokota, C | 1 |
| Asao, H; Beppu, H; Hanai, JI; Kimura, Y; Miura, S; Miyazono, K; Murata, K; Sasaki, Y; Sugamura, K; Takeshita, T; Tsukazaki, T; Wrana, JL | 1 |
| Ge, W | 1 |
| Bilezikjian, LM; Blount, AL; Chen, Y; Corrigan, AZ; Vale, WW | 1 |
| Aberg, T; Galceran, J; Grosschedl, R; Koppinen, P; Laurikkala, J; Mikkola, M; Mustonen, T; Nieminen, P; Pispa, J; Thesleff, I | 1 |
| Bernard, DJ; Chapman, SC; Woodruff, TK | 1 |
| Chapman, SC; Woodruff, TK | 1 |
| Jonas, C; Krebs, R; Röher, HD; Schulte, KM | 1 |
| Bartholin, L; Bertrand, S; Gadoux, M; Jeanpierre, S; Magaud, JP; Maguer-Satta, V; Martel, S; Rimokh, R | 1 |
| Cao, Z; Felici, A; Frank, DB; Green, HM; Lechleider, RJ; McNally, JG; Roberts, AB; Schneider, MD; Wurthner, JU | 1 |
| Bauskin, AR; Breit, SN; Brown, PK; Fairlie, WD; Pankhurst, SL; Russell, PK; Wu, WM; Zhang, HP | 1 |
| Ali, S; Cocolakis, E; Lebrun, JJ; Lemay, S | 1 |
| Auersperg, N; Choi, KC; Kang, SK; Leung, PC; Tai, CJ | 1 |
| Attisano, L; Chazaud, C; Hoodless, PA; Labbé, E; Pye, M; Rossant, J; Wrana, JL | 1 |
| Perrimon, N; Vincent, S | 1 |
| Attisano, L; Izzi, L; Labbé, E; Silvestri, C | 1 |
| Bosman, EA; Collart, C; Huylebroeck, D; Nelles, L; Umans, L; Van de Putte, T; van Grunsven, LA; Verschueren, K; Wuytens, G; Zwijsen, A | 1 |
| Chang, H; Lau, AL; Matzuk, MM | 1 |
| Checchin, D; Fehniger, TE; Heldin, CH; Rosendahl, A; Sideras, P; ten Dijke, P | 1 |
| Kawakami, M; Nakanishi, N | 1 |
| Bartholin, L; Bertrand, S; Corbo, L; Gadoux, M; Hayette, S; Lamadon, C; Magaud, JP; Maguer-Satta, V; Martel, S; Morera, AM; Rimokh, R | 1 |
| Asselin, J; Groome, NP; Mohan, A; Muttukrishna, S; Sargent, IL | 1 |
| Harada, J; Ishii, S; Takagi, T | 1 |
| Hirschberg, R; Lapage, J; Wang, SN | 1 |
| Hasegawa, Y; Ichikawa, T; Kogure, K; Kojima, I; Mori, M; Takagi, H; Zhang, YQ | 1 |
| Christ, B; Huang, R; Lang, ER; Otto, WR; Patel, K | 1 |
| Wright, CV | 1 |
| Gluhak-Heinrich, J; Gu, TT; Knight, C; MacDougall, M; Pavlin, D; Simmons, D; Zeichner-David, M | 1 |
| Beer, HD; Lüscher, B; Mauch, C; Werner, S | 1 |
| Beck, HN; Chandrasekaran, V; Dattatreyamurty, B; Higgins, D; Horbinski, C; Kaplan, PL; Lein, P; Robak, LA; Roux, E | 1 |
| Gao, Y; Koseki, T; Murase, Y; Nishihara, T; Okahashi, N; Sato, T; Tsujisawa, T; Yamato, K | 1 |
| Abe, E; Coker, JK; Gaddy-Kurten, D; Jilka, RL; Manolagas, SC | 1 |
| Kruse, FE; You, L | 1 |
| Ball, EM; Risbridger, GP | 2 |
| Aoki, TO; Mathieu, J; Peyriéras, N; Rebagliati, MR; Rosa, FM; Saint-Etienne, L | 1 |
| Evans, LW; Hughes, RD; Langley, PG; Norris, S; Yuen, MF | 1 |
| Amthor, H; Christ, B; Kemp, CF; Lang, E; Patel, K; Rashid-Doubell, F | 1 |
| Gonez, LJ; Harrison, LC; Jiang, FX; Stanley, EG | 1 |
| Breitkopf, K; Dooley, S; Gressner, AM; Weiskirchen, R | 1 |
| Luo, S; Peng, C; Wu, D; Yu, H | 1 |
| Entchev, EV; González-Gaitán, MA | 1 |
| Hilton, E; Old, R; Rex, M | 1 |
| Huang, X; Li, X; Qi, ZL; Wang, W | 1 |
| McGee, EA; Oakley, J; Xu, J | 1 |
| Davies, MV; Esquela, AF; Haynes, P; Koniaris, LG; Lee, SJ; McPherron, AC; Tomkinson, KN; Wolfman, NM; Zimmers, TA | 1 |
| Baillie, AJ; Drummond, AE; Dyson, ML; Ethier, JF; Findlay, JK; Robertson, DM | 1 |
| Callahan, JF; Gaster, LM; Harling, JD; Hill, CS; Inman, GJ; Laping, NJ; Nicolás, FJ; Reith, AD | 1 |
| Anand, M; Burke, RM; Dinsio, KJ; Hall, AK | 1 |
| Altmann, CR; Bell, E; Brivanlou, AH; Chang, C; Heke, M; Muñoz-Sanjuán, I; Rifkin, DB | 1 |
| Habas, R; He, X; Kato, Y; Katsuyama, Y; Näär, AM | 1 |
| Burns, KH; Davidson, L; Harlow, CR; Hillier, SG; Matzuk, MM; Yan, C | 1 |
| Dignass, AU; Harder-d'Heureuse, J; Jung, S; Wiedenmann, B | 1 |
| Gumbiner, BM; Vonica, A | 1 |
| Keutmann, H; Schneyer, A; Sidis, Y; Welt, C | 1 |
| Kumano, G; Smith, WC | 1 |
| Bondestam, J; Fujii, M; Groome, N; Hydén-Granskog, C; Jalanko, A; Kaivo-oja, N; Kallio, J; Moustakas, A; Ritvos, O; ten Dijke, P | 1 |
| Sive, HL; Smith, JC; Sun, BI; White, RJ | 1 |
| Hayashi, H; Imamura, T; Ishisaki, A; Li, AJ | 1 |
| Otsuka, F; Shimasaki, S | 1 |
| Ali, S; Cocolakis, E; Krystal, G; Lacerte, A; Lebrun, JJ; Lee, EH; Valderrama-Carvajal, H | 1 |
| Andreazzoli, M; Dawid, IB; Rebbert, ML; Takahashi, N; Toyama, R; Watanabe, M; Whitman, M; Zimmerman, S | 1 |
| Ethier, JF; Farnworth, PG; Findlay, JK; Ooi, GT | 1 |
| Brown, CW; Chang, H; Matzuk, MM | 1 |
| Bauerschmidt, S; de Jong, DS; Olijve, W; Steegenga, WT; van Zoelen, EJ | 1 |
| Branford, WW; Yost, HJ | 1 |
| Bagnoli, F; Calonaci, G; De Felice, C; Florio, P; Lombardi, I; Luisi, S; Petraglia, F | 1 |
| Bartholin, L; Ffrench, M; Jeanpierre, S; Magaud, JP; Maguer-Satta, V; Martel, S; Rimokh, R | 1 |
| Fang, DC; Huang, JF; Lu, R | 1 |
| Evans, LW; Hughes, RD | 1 |
| Krieglstein, K; Unsicker, K | 1 |
| Altmann, CR; Bell, E; Brivanlou, AH; Muñoz-Sanjuán, I; Vonica, A | 1 |
| Jiang, EP; Zhang, YQ | 1 |
| Brivanlou, AH; Chang, C; Eggen, BJ; Weinstein, DC | 1 |
| De Sauvage, FJ; Gao, WQ; Koeppen, H; Ross, S; Shou, J; Wang, BE | 1 |
| Koster, MI; Li, AG; Wang, XJ | 1 |
| Jardetzky, TS; Thompson, TB; Woodruff, TK | 1 |
| Cordenonsi, M; Dupont, S; Imbriano, C; Insinga, A; Maretto, S; Piccolo, S | 1 |
| Calp, MK; Matsumoto, JA; Van Der Kraak, G | 1 |
| Hsueh, AJ; Mazerbourg, S | 1 |
| Fabre, S; Lecerf, F; Monget, P; Monniaux, D; Mulsant, P; Pierre, A; Pisselet, C; Pohl, J | 1 |
| Abe, M; Funaba, M; Ikeda, T; Murakami, M; Ogawa, K | 2 |
| Abe, K; Hirakawa, T; Inoue, K; Matsuda, H; Minegishi, T; Miyamoto, K; Nakamura, K; Oomori, Y; Tsuchiya, M | 1 |
| de Kretser, DM; Lin, SY; Morrison, JR; Phillips, DJ | 1 |
| Shen, MM | 1 |
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| de Gorter, DJ; Jankipersadsing, V; Ten Dijke, P | 1 |
| Botta, A; Delteil, F; Estrach, S; Gagnoux-Palacios, L; Lemichez, E; Meneguzzi, G; Mettouchi, A; Négroni, L; Stefani, C; Vieira, A | 1 |
| Hinck, AP | 1 |
| Bauer, J; Cabral, J; Gomez, J; Jung, B; Sporn, JC | 1 |
| Korošec, P; Košnik, M; Silar, M; Zidarn, M | 1 |
| Cho, CH; Docherty, FM; Docherty, HM; Docherty, K; Hannan, NR; Joåo Lima, M; Trotter, MW; Vallier, L | 1 |
| Mukherjee, A; Robertson, RD | 1 |
| Hardy, CL; Harrison, CA; Loveland, KL; Mohamud, R; Nguyen, HA; O'Hehir, RE; Oh, DY; Plebanski, M; Rolland, JM; Yao, J | 1 |
| Dalton, S | 1 |
| Bushway, P; Cashman, JR; Gilley, C; Lanier, M; Mercola, M; Okolotowicz, K; Schade, D; Wahlquist, C; Willems, E | 1 |
| Rodríguez-Martínez, G; Velasco, I | 1 |
| Herman, TG; Holbrook, S; Kniss, JS | 1 |
| Lebrun, JJ; Neel, JC | 1 |
| Logan, TT; Symes, AJ; Villapol, S | 1 |
| Bhargava, V; Ko, P; Mercola, M; Subramaniam, S; Willems, E | 1 |
| Gold, E; Marino, FE; Risbridger, G | 1 |
| Fukuda, T; Gu, J; Gu, W; Hashimoto, H; Isaji, T; Wang, Y | 1 |
| Chuva de Sousa Lopes, SM; De Sutter, P; Deforce, D; Deroo, T; Duggal, G; Heindryckx, B; Lierman, S; O'Leary, T; Van der Jeught, M; Vossaert, L; Warrier, S | 1 |
| Bates, TJ; Bell, E; Brivanlou, AH; Heasman, J; Vonica, A | 1 |
| Elinson, RP; Karadge, U | 1 |
| Chuva de Sousa Lopes, SM; De Sutter, P; Deforce, D; Deroo, T; Duggal, G; Ghimire, S; Heindryckx, B; Lierman, S; O'Leary, T; Van der Jeught, M; Van Roy, N | 1 |
| Chen, SY; Cheng, WC; Huang, HN; Hwang, SM; Lu, FL; Lu, J; Ma, N; Mai, W; Schuyler, SC; Su, MW; Wang, HW; Yu, CC | 1 |
| Chen, H; Dong, L; Dong, XM; Feng, ZW; Ge, CH; Jia, YX; Jiang, YN; Li, CY; Liu, ED; Ning, HM; Tang, LJ; Wang, J; Yang, XM; Yang, Y; Yin, RH; Yu, M; Zhan, YQ; Zheng, WW | 1 |
| Calvo, F; Conway, EM; Lei, V; O'Byrne, AM; Suresh Babu, S; Valdez, Y; Xu, A | 1 |
| O'Connor, MB; Peterson, AJ | 1 |
| Ahn, C; Choe, S; Esquivies, L; Gray, PC; Kwiatkowski, W; Ye, SK; Yoon, BH | 1 |
| Hirafuji, M; Iizuka, K; Machida, T | 1 |
| Diekmann, U; Lenzen, S; Naujok, O | 1 |
| Gregorevic, P; Sandri, M; Sartori, R | 1 |
| Cooper-White, JJ; Frith, JE; Frith, TJ; Ovchinnikov, DA; Whitworth, DJ; Wolvetang, EJ | 1 |
| Bodenstine, TM; Gilgur, A; Hendrix, MJ; Hinck, AP; Khalkhali-Ellis, Z; Kirschmann, DA; Seftor, EA | 1 |
| Zhao, Z | 1 |
| Kim, MJ; O'Connor, MB | 1 |
| Chng, WA; Lemaitre, B; Schüpfer, F; Sleiman, MSB | 1 |
| Gao, RF; Jiang, J; Li, H; Li, ZD; Lin, RX; Yang, LH; Zhang, NS; Zhao, Q; Zhu, KT | 1 |
| Bracke, KR; Brusselle, GG; Joos, GF; Verhamme, FM | 1 |
| Al-Musawi, SL; Chen, JL; El-Osta, A; Gregorevic, P; Harrison, CA; Kelly, EK; La, M; Lazarus, R; Lovrecz, G; Lu, L; Qian, H; Walton, KL; Ziemann, M | 1 |
| Kenny, LC; O'Keeffe, GW; Williamson, RD | 1 |
| Dearden, PK; Grande, C; Hui, JH; Kenny, NJ; Namigai, EK; Shimeld, SM | 1 |
| Sandri, M; Sartori, R | 1 |
| Andrzejewski, D; Bonomi, L; Brown, ML; Burnside, A; Schneyer, A; Ungerleider, N | 1 |
| Cui, W; Czapiewski, R; Holt, MK; Murphy, N; Ramasamy, TS; Wei, SK; Yu, JS | 1 |
| Chen, YG; Fu, Y; Guan, Z; Hu, Z; Ma, X; Min, Z; Su, H; Sun, G; Tao, Q; Wu, W; Yan, X; Zhang, MQ | 1 |
| Adachi, S; Handa, O; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Kimura, R; Kokura, S; Matsuyama, T; Mizushima, K; Naito, Y; Oka, K; Okajima, M; Okayama, T; Sakai, H; Sakamoto, N; Takagi, T; Uchiyama, K | 1 |
| Bachert, C; Crombruggen, KV; Hong, S; Hu, G; Lan, F; Yang, Y; Zhang, N | 1 |
| McGee, EA; Raj, RS | 1 |
| Musso, T; Seeger, P; Sozzani, S | 1 |
| Carl, C; Dahlke, M; Dunst, J; Flindt, A; Gieseler, F; Hartmann, J; Lehnert, H; Rades, D; Ungefroren, H | 1 |
| Chung, H; Kim, J; Kim, KY; Lee, BK; Lee, J; Park, IH; Rhee, C; Shen, W | 1 |
| Fan, XC; Li, SJ; Qin, N; Tyasi, TL; Wei, ML; Xu, RF; Xu, XX; Zhang, YY | 1 |
| Lin, HY; Nana, AW; Yang, PM | 1 |
| Ebise, H; Hino, K; Horigome, K; Ikeya, M; Matsuda, S; Matsumoto, Y; Nagata, S; Nishio, M; Sekiguchi, K; Shibata, M; Toguchida, J | 1 |
| Fallahi, H; Massumi, M; Mohammadnia, A; Neely, E; Pourasgari, F; Yaqubi, M | 1 |
| Ahmad, Z; Davis, AM; Dawson, CW; Dudman, JP; Laverick, L; Morris, MA; Raveenthiraraj, S; Yap, LF; Young, LS | 1 |
| Aykul, S; Martinez-Hackert, E | 2 |
| Bahn, A; Gold, E; Rodrigues, E; Sangkop, F; Singh, G | 1 |
| Cui, Y; He, JT; Liang, WZ; Liu, HY; Mang, J; Shao, YK; Shi, W; Wang, JQ; Xu, ZH; Xu, ZX; Xue, LX | 1 |
| Gold, EJ; Nicholson, HD; Ottley, EC | 1 |
| Anderson, RA; Bastian, NA; Bayne, RA; Bonner, WM; Hartanti, MD; Hatzirodos, N; Hummitzsch, K; Irving-Rodgers, HF; Rodgers, RJ | 1 |
| Budde, I; Davenport, C; Detering, N; Diekmann, U; Naujok, O | 1 |
| Belles, X; Fernandez-Nicolas, A; Santos, CG | 1 |
| Bilandzic, M; Findlay, JK; Ooi, GT; Stenvers, KL; Wang, Y | 1 |
| Castillo, JC; Eleftherianos, I; Patrnogic, J | 1 |
| Chang, HM; Cheng, JC; Klausen, C; Leung, PC; Liu, Y; Xu, C | 1 |
| Hermine, O; Mies, A; Platzbecker, U | 1 |
| Briggs, NE; Dekker, GA; Robertson, SA; Sharkey, DJ; Tremellen, KP | 1 |
| Chakkalakal, JV; Krolewski, JJ; Nastiuk, KL; Pan, C; Sahasrabudhe, DM; Singh, S | 1 |
| Helin, H; Kalra, B; Kumar, A; Mistry, S; Palin, NK; Pasternack, A; Rintala, JM; Ritvos, O; Roth, MP; Savikko, J | 1 |
| Beauchamp, D; Jung, B; Staudacher, JJ | 1 |
| Chen, W; Ten Dijke, P | 1 |
| Moses, HL; Owens, P; Pickup, MW | 1 |
| de Heer, E; de Vinuesa, AG; Fog-Tonnesen, M; Høj Thomsen, L; Krarup Hansen, T; Nielsen Fink, L; Norlin, J; Rosendahl, A; Ten Dijke, P | 1 |
| Ashida, Y; Hirota, A; Nakajima-Koyama, M; Nishida, E; Yamamoto, T | 1 |
| Casares, F; Correia, A; Eusebio, N; Marinho, J; Martins, T; Pereira, PS | 1 |
| Bakker, A; Hawinkels, LJAC; Hierck, BP; Kunnen, SJ; Leonhard, WN; Peters, DJM; Poelma, C; Semeins, C; Ten Dijke, P | 1 |
| Alvarez, CV; Barrio, R; Cameselle-Teijeiro, JM; de Miguel, MP; de Rijke, YB; Díaz-Rodríguez, E; Escudero, A; Fernández, A; García, M; García-Lavandeira, M; Garcia-Rendueles, AR; Gorbenko Del Blanco, D; Hinkle, PM; Hokken-Koelega, AC; Lapunzina, P; Matre, V; Moreno, JC; Nevado, J; Nistal, M; Vallespín, E | 1 |
| Jin, AY; Li, H; Shen, MH; Xu, YT; Zhu, R | 1 |
| Fernández-Solà, J; Planavila, A; Villarroya, F | 1 |
| Jaźwińska, A; Pfefferli, C | 1 |
| Cui, X; Deng, J; Feng, W; Lin, F; Liu, Z; Santos, S; Tian, G; Wu, J; Xie, D; Yang, K | 1 |
| Lee, JH; Yoon, BH; Zheng, GB | 1 |
| Chen, JL; Colgan, TD; Gregorevic, P; Hagg, A; Harrison, CA; Johnson, K; Qian, H; Walton, KL | 1 |
| Einarsdottir, E; Ingerpuu, S; Jaks, V; Katayama, S; Kere, J; Koel, M; Krjutškov, K; Lundin, K; Salumets, A; Stenman, UH; Tapanainen, J; Tuuri, T; Võsa, U | 1 |
| Bauer, J; Carroll, T; Grippo, P; Guzman, G; Jana, A; Jung, B; Kerr, D; Krett, N; Mancinelli, G; Özden, Ö; Staudacher, JJ; Tian, J | 1 |
| Hino, K; Horigome, K; Ikeya, M; Jin, Y; Kawakami, K; Komura, S; Nagata, S; Nishio, M; Ohta, A; Toguchida, J; Yamada, Y; Zhao, C | 1 |
| El-Kerdasy, HI; Hussien, NI; Ibrahim, ME | 1 |
| Chng, WA; Koch, R; Kondo, S; Lemaitre, B; Li, X; Nagoshi, E | 1 |
| Castanas, E; Kampa, M; Kiagiadaki, F; Kouroumalis, E; Notas, G; Voumvouraki, A | 1 |
| Mueller, TD; Nickel, J; Ten Dijke, P | 1 |
| Cotton, TR; Czepnik, M; Gregorevic, P; Hagg, A; Harrison, CA; Hyvönen, M; Lee, RT; McCoy, JC; Mills, MJ; Thompson, TB; Walker, RG; Walton, KL | 1 |
| Chen, XP; Ding, ZY; Jin, GN; Liang, HF; Sun, YM; Wang, W; Wu, Y; Xiong, YX; Yu, B; Zhang, B | 1 |
| Bibikova, E; Danilova, N; Lin, S; Sakamoto, KM; Wilkes, M; Youn, MY | 1 |
| Chen, F; Fei, X; Jin, W; Song, Y; Wang, K; Wu, B | 1 |
| Jelkmann, W | 1 |
| Cheng, D; Ghosh, AC; Perrimon, N; Song, W | 1 |
| Cronin, E; Goncharov, DA; Goncharova, EA; Kudryashova, TV; Okorie, E; Pena, A; Shen, Y | 1 |
| Brivanlou, AH; Carroll, T; Etoc, F; Kirst, C; Li, S; Martyn, I; Metzger, JJ; Ruzo, A; Siggia, ED; Yoney, A | 1 |
| Doi, S; Funaba, M; Hashimoto, O; Inoue, K; Itoi, H; Kurisaki, A; Matsumura, S; Morita, M; Oiwa, H; Oyadomari, S; Satoh, R; Sekiyama, K; Shindo, D; Sugino, H; Sugiyama, M; Suzuki, C; Takada, H; Yamakawa, N | 1 |
| Bloxham, RD; Chakravarty, P; Das, D; Gori, I; Hill, CS; Howell, M; Jiang, M; Miller, DSJ; Saunders, RE | 1 |
| Fried, SK; Jager, M; Karastergiou, K; Layne, MD; Lee, MJ; Pickering, RT; Shibad, V; Wu, Y | 1 |
| Hashimoto, O; Morita, M | 1 |
| Alvarenga, O; Liu, Y; Massey, J; Saez, T; Schmerer, M; Warmflash, A | 1 |
| Cui, X; Liu, Z; Lv, X; Qi, Y; Shang, S; Zhao, J | 1 |
| Hanahan, D; Marinoni, I; Michael, IP; Perren, A; Saghafinia, S; Tichet, M; Zangger, N | 1 |
| Hill, CS; Miller, DSJ; Schmierer, B | 1 |
| Andersen, CY; Bøtkjær, JA; Colmorn, LB; Ernst, E; Fedder, J; Franks, S; Hardy, K; Kalra, B; Kristensen, SG; Kumar, A; Mamsen, LS; Owens, LA; Pors, SE | 1 |
| Bauer, A; Cui, C; Kiełbasa, S; Li, Y; Mei, H; Ten Dijke, P; van Dam, H; van Dinther, M; Xie, F; Zhang, L | 1 |
| Boisvert, A; Castonguay, R; Corpina, RA; Czepnik, M; Economides, AN; Fullerton, PT; Goebel, EJ; Grenha, R; Hinck, AP; Hinck, CS; Idone, VJ; Kumar, R; Matzuk, MM; Miklossy, G; Thompson, TB | 1 |
| Chen, S; Li, G; Shang, C; Wang, Y; Wu, X; Zhang, H | 1 |
| Huang, Q; Li, Q | 1 |
| Hayashi, Y; Hitachi, K; Saitoh, M; Taguchi, A; Takayama, K; Taniguchi, A; Tsuchida, K | 1 |
| Bauer, J; Emon, MAB; Jung, B; Krett, N; Mancinelli, G; Saif, MT; Staudacher, JJ; Thomas, AL; Zessner-Spitzenberg, J | 1 |
| Chen, CH; Chen, PL; Chu, SY; Lai, YW; Li, JC; Yu, HH | 1 |
| Elsaadi, S; Hella, H; Holien, T; Jacobi, C; Martinez-Hackert, E; Olsen, OE | 1 |
| Bao, ZD; Cheng, R; Mao, XN; Pan, JJ; Shen, YQ; Yang, Y; Zhou, XG; Zhou, XY | 1 |
| Kayastha, P; Reich, S; Teegala, S; Weinstein, DC | 1 |
| Loveland, KL; Moody, SC; Wakitani, S; Western, PS; Young, JC | 1 |
| Andl, CD; Farmer, SM | 1 |
| Desplan, C; Rossi, AM | 1 |
| Hao, J; Jiang, W; Lacroix, JJ; Luo, Y; Xie, C | 1 |
| An, C; Auerbach, BD; Caccamise, A; Cobb, MM; Dietz, DM; Gancarz, AM; Gobira, PH; Iida, M; Martin, JA; Mitra, S; Neve, RL; Salvi, RJ; Stewart, AF; Wang, ZJ; Werner, CT | 1 |
| Alard, A; Daviaud, C; De Martino, M; Demaria, S; Diamond, JM; Formenti, SC; Kraynak, J; Miller, LD; Vanpouille-Box, C | 1 |
| Bi, Y; Guo, Z; Li, JL; Li, P; Markovic-Plese, S; Seyedsadr, M; Wan, YY; Wu, B; Xu, X; Zhang, S; Zhou, M | 1 |
| Lodberg, A | 1 |
| Donahoe, PK; Harrison, CA; Hart, KN; Nagykery, NG; Pépin, D; Stocker, WA; Thompson, TB; Walton, KL | 1 |
| Bharambe, HS; Deogharkar, A; Masurkar, SA; Shirsat, NV | 1 |
| Brivanlou, AH; Etoc, F; Galgoczi, S; Haremaki, T; Li, S; Markopoulos, C; Metzger, JJ; Phan-Everson, T; Ruzo, A; Yoney, A | 1 |
| Goh, HN; Kaufman-Francis, K; Knowles, H; Osteil, P; Salehin, N; Santucci, N; Studdert, J; Tam, PPL | 1 |
| Amsalem-Zafran, AR; Ehrlich, M; Henis, YI; Shapira, KE; Szilágyi, SS | 1 |
| Alaimo, A; Antoccia, A; Barbareschi, M; Berardinelli, F; Bertossi, A; Bertossio, E; Bisio, A; Cambuli, F; Celotti, M; De Felice, D; Fiorentino, M; Foletto, V; Gandolfi, F; Gaspari, M; Genovesi, S; Loda, M; Lorenzoni, M; Lunardi, A; Mazzero, G; Palumbieri, MD; Romanel, A; Shen, MM; Zaffagni, M | 1 |
| Coda, DM; Gaarenstroom, TE; Gori, I; Hill, CS; Howell, M; Patel, H; Song, OR | 1 |
| Gong, L; Liu, B; Liu, L; Lü, Z; Pang, Z; Zhao, S | 1 |
| Hao, J; Meng, X; Wang, H | 1 |
| Chin, V; Daneshvar, D; Karikios, D; Lim, J; McCloy, R; Murphy, A; Nagrial, A; O'Toole, S; Steinmann, AM; Wong, S | 1 |
| Apostolidou, A; Divolis, G; Doulou, A; Ford, E; Gavriil, A; Germanidis, G; Katsantoni, E; Kloukina, I; Manioudaki, M; Perrea, DN; Ritvos, O; Sideras, P; Sountoulidis, A; Stavropoulos, A; Xilouri, M | 1 |
| Gong, L; Li, F; Long, Y; Tong, Y; Yu, X | 1 |
| Bai, J; Liang, T; Lin, H; Ma, S; Tao, Q; Xi, Q; Zhou, W; Zhu, X | 1 |
| Chalasani, N; Culver, A; Dai, G; Garcia, V; Hamang, M; Jiang, H; Kusumanchi, P; Lee, J; Liangpunsakul, S; Wang, Y; White, E; Yaden, BC; Yanum, J | 1 |
| Jin, Y; Kamakura, T; Kawai, S; Maekawa, H; Matsuda, S; Nagata, S; Nishio, M; Niwa, A; Saito, MK; Toguchida, J; Yoshitomi, H | 1 |
| Dai, J; Deng, P; Fu, H; Huang, W; Jiang, S; Kong, X; Liu, JG; Sun, H; Xi, Q; Yan, K; Zhang, QC | 1 |
| Bi, J; Feng, Q; Li, J; Song, Q; Stanley, D; Yin, L | 1 |
| Desharnais, P; Naud, JF | 1 |
| Chen, HH; Hu, H; Jiang, ZJ; Li, QY; Liu, XJ; Luo, LT; Wang, B; Zeng, MX; Zhang, FM | 1 |
| Barsoumian, H; Cortez, MA; Duong, LK; Ganjoo, S; Hsu, E; Nanez, S; Puebla-Osorio, N; Voss, T; Welsh, JW | 1 |
| Notas, G | 1 |
| Konrad, L; Maoga, JB; Mecha, E; Meinhold-Heerlein, I; Mwaura, AN; Omwandho, COA; Riaz, MA; Scheiner-Bobis, G | 1 |
| Gao, B; Kakoki, M; Khajehei, M; Krepinsky, JC; Li, R; MacDonald, M; O'Neil, K; Soomro, A; Zhang, D | 1 |
| Emoto, N; Hara, T; Musthafa, A; Ryanto, GRT | 1 |
| Buechler, C; Mester, P; Treeck, O; Weber, F | 1 |
| Iaria, J; Loveland, KL; Luu, M; McLaughlin, EA; Radhakrishnan, K; Sutherland, JM; Zhu, HJ | 1 |
| Babaniamansour, S; Bedi, K; Cao, Y; Crawford, H; di Magliano, MP; Dou, Y; Ge, K; Gu, Y; Jeyarajan, S; Kim, HS; Ljungman, M; Lu, S; Magnuson, B; Narayanan, IV; Paulsen, MT; Qiu, P; Shameon, S; Shi, J; Thomas, D; Xu, C; Yang, B; Yang, J; Yi, Z; Zhao, L | 1 |
| Lan, Z; Lv, Z; Xiao, Y; Zuo, W | 1 |
| Esteve-Codina, A; Ninfali, C; Postigo, A; Siles, L | 1 |
| Chen, D; Chen, G; Chen, P; Chen, X; Gu, Y; Leng, D; Li, X; Liu, W; Song, C; Wang, X; Wu, H; Wu, Q; Xiao, J; Xie, S; Ye, Y; Zhang, W; Zhao, Q | 1 |
104 review(s) available for activins and transforming growth factor beta
| Article | Year |
|---|---|
Transforming growth factor beta/inhibin family.
Topics: Activins; Amino Acid Sequence; Animals; Gene Expression; Humans; Inhibins; Molecular Sequence Data; Transforming Growth Factor beta | 1991 |
Activins and the receptor serine kinase superfamily.
Topics: Activin Receptors; Activins; Animals; Growth Hormone; Humans; Inhibins; Pituitary Gland; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Receptors, Peptide; Signal Transduction; Transforming Growth Factor beta | 1995 |
[TGF beta (transforming growth factor beta) and its related peptides in the local control of the testicle].
Topics: Activins; Follicle Stimulating Hormone; Growth Substances; Humans; Inhibins; Leydig Cells; Male; Sertoli Cells; Testis; Transforming Growth Factor beta | 1994 |
[Inhibin, activin, follistatin, and transforming growth factor beta (TGF-beta): presence in the ovary and possible role in the regulation of folliculogenesis in primates].
Topics: Activins; Animals; Female; Follistatin; Glycoproteins; Growth Substances; Inhibins; Ovary; Primates; Transforming Growth Factor beta | 1994 |
Transforming growth factor-beta gene family members and bone.
Topics: Activins; Animals; Bone and Bones; Bone Resorption; Carrier Proteins; Humans; Inhibins; Osteogenesis; Signal Transduction; Transforming Growth Factor beta | 1994 |
Type beta transforming growth factors and activins in differentiating embryonal carcinoma cells, embryonic stem cells and early embryonic development.
Topics: Activin Receptors; Activins; Animals; Cell Differentiation; Follistatin; Glycoproteins; Inhibins; Mice; Receptors, Cell Surface; Stem Cells; Teratoma; Transforming Growth Factor beta | 1993 |
[Paracrine regulation of Leydig cells].
Topics: Activins; Animals; Coculture Techniques; Humans; Inhibins; Insulin-Like Growth Factor I; Leydig Cells; Male; Sertoli Cells; Transforming Growth Factor beta | 1996 |
Role of growth factors in the developmental regulation of the human fetal adrenal cortex.
Topics: Activins; Adrenal Cortex; Adrenocorticotropic Hormone; Embryonic and Fetal Development; Epidermal Growth Factor; ErbB Receptors; Fibroblast Growth Factor 2; Gene Expression Regulation, Developmental; Growth Substances; Humans; Inhibins; Transforming Growth Factor beta | 1997 |
Cellular dialogues in organogenesis.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Communication; Embryo, Mammalian; Embryonic and Fetal Development; Gene Expression Regulation, Developmental; GTP-Binding Proteins; Homeodomain Proteins; Humans; Inhibins; Organ Specificity; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor beta | 1996 |
[Functions of TGF-beta superfamily members in reproduction].
Topics: Activins; Amino Acid Sequence; Animals; Anti-Mullerian Hormone; Bone Morphogenetic Protein 15; Bone Morphogenetic Proteins; Female; Gene Deletion; Germ Cells; Glycoproteins; Growth Differentiation Factor 9; Growth Inhibitors; Growth Substances; Inhibins; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Knockout; Molecular Sequence Data; Reproduction; Sex Differentiation; Testicular Hormones; Transforming Growth Factor beta | 1998 |
Is the action of inhibin mediated via a unique receptor?
Topics: Activin Receptors; Activins; Binding, Competitive; Humans; Inhibins; Receptors, Growth Factor; Receptors, Peptide; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2000 |
[The roles of TGF-beta superfamily in mouse early development].
Topics: Activins; Animals; Bone Morphogenetic Proteins; Gene Targeting; Inhibins; Mice; Mice, Knockout; Morphogenesis; Neural Crest; Signal Transduction; Transforming Growth Factor beta | 2000 |
Roles of the activin regulatory system in fish reproduction.
Topics: Activin Receptors; Activins; Animals; Autocrine Communication; Cloning, Molecular; Fishes; Follistatin; Glycoproteins; Gonadotropins; Inhibins; Left-Right Determination Factors; Paracrine Communication; Receptors, Growth Factor; Recombinant Proteins; Reproduction; Transforming Growth Factor beta; Zebrafish Proteins | 2000 |
Mechanisms of inhibin signal transduction.
Topics: Activin Receptors; Activins; Animals; DNA, Complementary; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Humans; Inhibins; Ligands; Models, Biological; Neoplasms; Prostatic Secretory Proteins; Protein Binding; Protein Isoforms; Receptors, Peptide; Reproduction; Signal Transduction; Transforming Growth Factor beta | 2001 |
The transcriptional role of Smads and FAST (FoxH1) in TGFbeta and activin signalling.
Topics: Activins; Animals; DNA-Binding Proteins; Forkhead Transcription Factors; Humans; Nerve Growth Factors; Phosphoproteins; Protein Binding; Signal Transduction; Smad Proteins; Smad1 Protein; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad5 Protein; Smad6 Protein; Smad7 Protein; Smad8 Protein; Trans-Activators; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Xenopus Proteins; Zebrafish Proteins | 2001 |
Transforming growth factor beta signalling in vitro and in vivo: activin ligand-receptor interaction, Smad5 in vasculogenesis, and repression of target genes by the deltaEF1/ZEB-related SIP1 in the vertebrate embryo.
Topics: Activin Receptors; Activins; Animals; DNA-Binding Proteins; Drug Interactions; Homeodomain Proteins; Neovascularization, Physiologic; Phosphoproteins; Repressor Proteins; Signal Transduction; Smad5 Protein; Trans-Activators; Transforming Growth Factor beta; Vertebrates; Zinc Finger E-box Binding Homeobox 2 | 2001 |
Studying TGF-beta superfamily signaling by knockouts and knockins.
Topics: Activins; Animals; DNA-Binding Proteins; Embryonic and Fetal Development; Female; Inhibins; Male; Mice; Mice, Knockout; Mice, Mutant Strains; Phosphoproteins; Signal Transduction; Smad5 Protein; Trans-Activators; Transforming Growth Factor beta | 2001 |
Activins as regulators of branching morphogenesis.
Topics: Activins; Animals; Breast; Cell Differentiation; Cell Division; Epithelium; Female; Gene Expression Regulation, Developmental; Humans; Inhibins; Kidney; Lung; Male; Mesoderm; Mice; Models, Biological; Pancreas; Prostate; Salivary Glands; Signal Transduction; Transforming Growth Factor beta | 2001 |
Roles of TGF-beta in hepatic fibrosis.
Topics: Activins; Animals; Apoptosis; Humans; Liver; Liver Cirrhosis; Models, Biological; Models, Molecular; Rats; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Morphogen gradient formation and vesicular trafficking.
Topics: Activins; Animals; Biological Transport; Drosophila; Drosophila Proteins; Dynamins; Endosomes; GTP Phosphohydrolases; Hedgehog Proteins; Lysosomes; Models, Biological; Proto-Oncogene Proteins; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; rab7 GTP-Binding Proteins; Signal Transduction; Transforming Growth Factor beta; Wnt1 Protein; Xenopus | 2002 |
[Transforming growth factor-beta superfamily in the regulation of new bone formation].
Topics: Activins; Animals; Bone Morphogenetic Proteins; In Vitro Techniques; Mice; Osteogenesis; Osteogenesis, Distraction; Rabbits; Rats; Transforming Growth Factor beta | 2002 |
Recruitment and development of the follicle; the roles of the transforming growth factor-beta superfamily.
Topics: Activin Receptors; Activins; Animals; Autocrine Communication; Bone Morphogenetic Proteins; Female; Humans; Ligands; Multigene Family; Ovarian Follicle; Paracrine Communication; Signal Transduction; Transforming Growth Factor beta | 2002 |
Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium.
Topics: Activins; Animals; Endocrine System; Female; Follicle Stimulating Hormone; Humans; Inhibins; Ovary; Receptors, Cell Surface; Reproduction; Signal Transduction; Transforming Growth Factor beta | 2002 |
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
Topics: Activins; Animals; Bone Morphogenetic Proteins; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Glial Cell Line-Derived Neurotrophic Factor; Growth Substances; Humans; Inhibins; Mice; Mice, Knockout; Mice, Transgenic; Nerve Growth Factors; Phylogeny; Protein Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta; Smad Proteins; Trans-Activators; Transforming Growth Factor beta | 2002 |
New perspectives on growth factor-sex steroid interaction in the prostate.
Topics: Activins; Cell Communication; Female; Gonadal Steroid Hormones; Growth Substances; Humans; Male; Prostate; Signal Transduction; Transforming Growth Factor beta | 2003 |
[The cellular signal transduction of TGF-beta family].
Topics: Activins; Animals; Bone Morphogenetic Proteins; DNA-Binding Proteins; Humans; Inhibins; Signal Transduction; Smad Proteins; Smad2 Protein; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta | 1999 |
TGF-betas and their roles in the regulation of neuron survival.
Topics: Activins; Animals; Cell Death; Cell Differentiation; Cell Survival; Inhibins; Multigene Family; Neurons; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2002 |
[The role of transforming growth factor beta superfamily in male germ cell development].
Topics: Activins; Animals; Anti-Mullerian Hormone; Bone Morphogenetic Proteins; Glycoproteins; Growth Inhibitors; Humans; Inhibins; Male; Spermatogenesis; Spermatozoa; Testicular Hormones; Transforming Growth Factor beta | 2002 |
Roles of TGFbeta signaling in epidermal/appendage development.
Topics: Activins; Animals; Epidermis; Extremities; Humans; Mice; Mice, Transgenic; Models, Biological; NF-kappa B; Phenotype; Proto-Oncogene Proteins; Signal Transduction; Time Factors; Transcription Factors; Transforming Growth Factor beta; Wnt Proteins; Zebrafish Proteins | 2003 |
Growth differentiation factor-9 signaling in the ovary.
Topics: Activins; Animals; Bone Morphogenetic Protein 15; Female; Gene Expression Regulation, Developmental; Granulosa Cells; Growth Differentiation Factor 9; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Models, Biological; Ovary; Recombinant Proteins; Signal Transduction; Theca Cells; Transforming Growth Factor beta | 2003 |
Regulation of ovarian function by the TGF-beta superfamily and follistatin.
Topics: Activins; Female; Follistatin; Homeostasis; Humans; Inhibins; Ovary; Protein Binding; Protein Isoforms; Signal Transduction; Transforming Growth Factor beta | 2003 |
Decrypting the role of Cripto in tumorigenesis.
Topics: Activins; Amino Acid Motifs; Animals; Cell Division; Epidermal Growth Factor; GPI-Linked Proteins; Humans; Intercellular Signaling Peptides and Proteins; Membrane Glycoproteins; Models, Biological; Neoplasm Proteins; Neoplasms; Nodal Protein; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 2003 |
The TGF-beta superfamily and its roles in the human ovary and placenta.
Topics: Activins; Carrier Proteins; Female; Humans; Inhibins; Ligands; Ovary; Placenta; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2003 |
Nodal signaling and vertebrate germ layer formation.
Topics: Activins; Animals; Body Patterning; Embryonic Induction; Gastrula; Germ Layers; Inhibin-beta Subunits; Intracellular Signaling Peptides and Proteins; Mesoderm; Mice; Nodal Protein; Nodal Signaling Ligands; Organizers, Embryonic; Signal Transduction; Transforming Growth Factor beta; Vertebrates; Xenopus laevis; Xenopus Proteins; Zebrafish Proteins | 2003 |
Extracellular control of pancreatic differentiation.
Topics: Activins; Cell Differentiation; DNA-Binding Proteins; Glucagon; Humans; Insulin; Pancreas; Retinoids; RNA, Messenger; Signal Transduction; Smad Proteins; Trans-Activators; Transforming Growth Factor beta | 2004 |
Regulation of BMP and activin signaling in Drosophila.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Drosophila; Drosophila Proteins; Ligands; Signal Transduction; Transforming Growth Factor beta | 2004 |
Transforming Growth Factor-beta superfamily: evaluation as breast cancer biomarkers and preventive agents.
Topics: Activins; Animals; Anti-Mullerian Hormone; Antineoplastic Agents; Biomarkers, Tumor; Bone Morphogenetic Proteins; Breast Neoplasms; Female; Glycoproteins; Humans; Inhibins; Nodal Protein; Signal Transduction; Testicular Hormones; Transforming Growth Factor beta | 2004 |
Inhibin: actions and signalling.
Topics: Activin Receptors; Activins; Animals; Humans; Inhibins; Proteoglycans; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2004 |
Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders.
Topics: Activins; Animals; Autoimmune Diseases of the Nervous System; Drug Delivery Systems; Endocrine System Diseases; Humans; Metabolic Diseases; Myostatin; Transforming Growth Factor beta | 2004 |
[Activin].
Topics: Activins; Animals; Cell Division; Collagen; Fibroblasts; Fibrosis; Follistatin; Humans; Kidney; Kidney Tubules; Morphogenesis; Regeneration; Signal Transduction; Transforming Growth Factor beta | 2004 |
Molecular biology of inhibin action.
Topics: Activin Receptors; Activins; Animals; Carrier Proteins; Humans; Inhibins; Molecular Biology; Multigene Family; Proteoglycans; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2004 |
Tgf-beta superfamily and mouse craniofacial development: interplay of morphogenetic proteins and receptor signaling controls normal formation of the face.
Topics: Activin Receptors; Activins; Animals; Bone Morphogenetic Proteins; Craniofacial Abnormalities; Embryonic Development; Embryonic Induction; Face; Growth Substances; Head; Inhibins; Ligands; Mice; Neural Crest; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2005 |
[TGF-beta family (TGF-beta, activin, BMP)].
Topics: Activins; Apoptosis; Bone Morphogenetic Proteins; Cell Differentiation; DNA-Binding Proteins; Fibrosis; Neoplasms; Neurons; Osteoblasts; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Ubiquitin | 2005 |
[Morphogens].
Topics: Activins; Animals; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Compartmentation; Diffusion; Drosophila melanogaster; Drosophila Proteins; Hedgehog Proteins; Intracellular Signaling Peptides and Proteins; Nodal Signaling Ligands; Organizers, Embryonic; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transforming Growth Factor beta; Vertebrates; Wnt1 Protein; Zebrafish Proteins | 2005 |
[Mesoderm induction and neural induction].
Topics: Activins; Animals; beta Catenin; Bone Morphogenetic Proteins; Carrier Proteins; Cell Communication; Cell Differentiation; Cytoskeletal Proteins; Embryonic Induction; Fibroblast Growth Factors; Follistatin; Glycoproteins; Intercellular Signaling Peptides and Proteins; Mesoderm; Nervous System; Organizers, Embryonic; Proteins; Signal Transduction; Trans-Activators; Transforming Growth Factor beta | 2005 |
[Regulation of skeletal muscle mass and adipose tissue mass by follistatin and follistatin-related gene (FLRG) and development of novel polypeptides as medical drugs].
Topics: Activin Receptors, Type II; Activins; Adipose Tissue; Animals; Drug Design; Follistatin; Follistatin-Related Proteins; Humans; Muscle, Skeletal; Myostatin; Peptides; Transforming Growth Factor beta | 2005 |
Culture development for human embryonic stem cell propagation: molecular aspects and challenges.
Topics: Activins; Bone Morphogenetic Proteins; Cell Adhesion; Cell Culture Techniques; Cell Proliferation; Coculture Techniques; Culture Media, Serum-Free; Embryo, Mammalian; Fibroblast Growth Factors; Growth Substances; Humans; Models, Biological; Nodal Protein; Stem Cells; Transforming Growth Factor beta | 2005 |
Drivers of germ cell maturation.
Topics: Activins; Animals; Biological Transport; Cell Differentiation; Cell Nucleus; Gene Expression Regulation, Developmental; Karyopherins; Male; Mice; Models, Biological; Signal Transduction; Spermatogenesis; Spermatozoa; Testis; Transforming Growth Factor beta | 2005 |
Emergence of organizer function: a lot of "stuff" involved.
Topics: Activins; Animals; beta Catenin; Body Patterning; Bone Morphogenetic Proteins; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Glycoproteins; Organizers, Embryonic; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins | 2006 |
[Attempt at renal regeneration].
Topics: Activins; Animals; Biocompatible Materials; Cell Differentiation; Cells, Cultured; Humans; Kidney; Kidney Transplantation; Multipotent Stem Cells; Regeneration; Tissue Engineering; Transforming Growth Factor beta; Tretinoin; Wnt Proteins | 2006 |
[Roles of inhibins, activins and related proteins in reproduction].
Topics: Activin Receptors; Activins; Animals; Female; Follicle Stimulating Hormone; Humans; Inhibins; Intracellular Signaling Peptides and Proteins; Latent TGF-beta Binding Proteins; Male; Pituitary Gland; Protein Binding; Reproduction; Signal Transduction; Transforming Growth Factor beta | 2006 |
[Ovarian tumors].
Topics: Activins; Animals; Biomarkers, Tumor; Female; Humans; Inhibins; Ovarian Neoplasms; Prognosis; Transforming Growth Factor beta | 2006 |
Building the mouse gastrula: signals, asymmetry and lineages.
Topics: Activins; Animals; Body Patterning; Cell Lineage; Cell Movement; Endoderm; Gastrula; Germ Cells; Membrane Proteins; Mice; Nodal Protein; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins | 2006 |
The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Membrane; Humans; Ligands; Protein Binding; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2006 |
Pituitary actions of ligands of the TGF-beta family: activins and inhibins.
Topics: Activins; Animals; Female; Follicle Stimulating Hormone; Follistatin; Humans; Inhibins; Male; Pituitary Gland; Reproduction; Signal Transduction; Transforming Growth Factor beta | 2006 |
TGF-beta superfamily expression and actions in the endometrium and placenta.
Topics: Activins; Animals; Decidua; Endometrium; Female; Humans; Inhibins; Menstruation; Placenta; Pregnancy; Signal Transduction; Transforming Growth Factor beta; Trophoblasts | 2006 |
All in the family: TGF-beta family action in testis development.
Topics: Activins; Animals; Fertility; Humans; Inhibins; Male; Puberty; Signal Transduction; Spermatogenesis; Testis; Transforming Growth Factor beta | 2006 |
The role of TGF-beta superfamily during T cell development: new insights.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; T-Lymphocytes; Thymus Gland; Transforming Growth Factor beta | 2007 |
Deconstructing digit chondrogenesis.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Chondrogenesis; Elastin; Extremities; Fibrillins; Fingers; High Mobility Group Proteins; Homeodomain Proteins; Humans; Microfilament Proteins; Models, Biological; Morphogenesis; Signal Transduction; Tenascin; Transforming Growth Factor beta; Tumor Suppressor Proteins | 2007 |
Signal transduction pathway through activin receptors as a therapeutic target of musculoskeletal diseases and cancer.
Topics: Activin Receptors; Activins; Animals; Antineoplastic Agents; Bone Morphogenetic Proteins; Drug Delivery Systems; Epidermal Growth Factor; GPI-Linked Proteins; Humans; Intercellular Signaling Peptides and Proteins; Membrane Glycoproteins; Models, Biological; Musculoskeletal Diseases; Myostatin; Neoplasm Proteins; Neoplasms; Protein Binding; Protein Kinase Inhibitors; Signal Transduction; Transforming Growth Factor beta | 2008 |
[TGFbeta, activin and SMAD signalling in thyroid cancer].
Topics: Activins; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Receptors, Growth Factor; Signal Transduction; Smad Proteins; Smad7 Protein; Thyroid Neoplasms; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Ubiquitin-Protein Ligases | 2007 |
Definitive endoderm: a key step in coaxing human embryonic stem cells into transplantable beta-cells.
Topics: Activins; Animals; Embryonic Stem Cells; Endoderm; Humans; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Nodal Protein; Transforming Growth Factor beta | 2008 |
Activin, TGF-beta and menin in pituitary tumorigenesis.
Topics: Activins; Adenoma; Gene Expression Regulation, Neoplastic; Humans; Pituitary Neoplasms; Prolactin; Proto-Oncogene Proteins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2009 |
Progresses and challenges in optimization of human pluripotent stem cell culture.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Culture Techniques; Cells, Cultured; Embryonic Stem Cells; Fibroblast Growth Factor 2; Genomic Instability; Humans; Nodal Protein; Pluripotent Stem Cells; Receptors, Notch; Transforming Growth Factor beta; Wnt Proteins | 2010 |
Regulation of embryonic stem cell self-renewal and differentiation by TGF-beta family signaling.
Topics: Activins; Bone Morphogenetic Proteins; Cell Differentiation; Cell Lineage; Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Signal Transduction; Transcription Factors; Transforming Growth Factor beta | 2010 |
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
Topics: Activins; Adipogenesis; Animals; Disease Models, Animal; Energy Metabolism; Humans; Mice; Signal Transduction; Transforming Growth Factor beta | 2011 |
Activin/nodal signaling and pluripotency.
Topics: Activins; Animals; Cell Differentiation; Embryonic Stem Cells; Humans; Nodal Protein; Nodal Signaling Ligands; Pluripotent Stem Cells; Signal Transduction; Transforming Growth Factor beta | 2011 |
Intracrine signaling mechanisms of activin A and TGF-β.
Topics: Activins; Animals; Gene Expression Regulation; Humans; Signal Transduction; Transforming Growth Factor beta | 2011 |
The role of activin/nodal and Wnt signaling in endoderm formation.
Topics: Activin Receptors; Activins; Animals; beta Catenin; Cell Differentiation; Embryonic Stem Cells; Endoderm; Humans; Nodal Protein; Nodal Signaling Ligands; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins | 2011 |
Role of activin A in the induction of Foxp3+ and Foxp3- CD4+ regulatory T cells.
Topics: Activins; Animals; Cell Differentiation; Forkhead Transcription Factors; Humans; Signal Transduction; T-Lymphocytes, Regulatory; Transforming Growth Factor beta | 2011 |
The role of activin in mammary gland development and oncogenesis.
Topics: Activins; Animals; Breast Neoplasms; Female; Humans; Mammary Glands, Animal; Mammary Glands, Human; Mammary Neoplasms, Experimental; Signal Transduction; Transforming Growth Factor beta | 2011 |
When versatility matters: activins/inhibins as key regulators of immunity.
Topics: Activins; Adaptive Immunity; Animals; Bone Marrow; Hematopoiesis; Humans; Immunity, Innate; Inhibins; Leukocytes; Mice; Phagocytes; Signal Transduction; Transforming Growth Factor beta | 2012 |
Activin-A: a novel critical regulator of allergic asthma.
Topics: Activins; Airway Remodeling; Animals; Asthma; Cytokines; Humans; Inflammation; Signal Transduction; Transforming Growth Factor beta | 2011 |
More than being protective: functional roles for TGF-β/activin signaling pathways at central synapses.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; Neurogenesis; Neurons; Signal Transduction; Synapses; Synaptic Transmission; Transforming Growth Factor beta | 2011 |
Context-dependent action of transforming growth factor β family members on normal and cancer stem cells.
Topics: Activins; Adult; Adult Stem Cells; Animals; Antineoplastic Agents; Bone Morphogenetic Proteins; Disease Progression; Drug Resistance, Neoplasm; Embryonic Stem Cells; Humans; Neoplasms; Neoplastic Stem Cells; Signal Transduction; Transforming Growth Factor beta | 2012 |
Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily.
Topics: Activin Receptors; Activins; Animals; Bone Morphogenetic Proteins; Evolution, Molecular; Humans; Models, Biological; Models, Molecular; Molecular Conformation; Phylogeny; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2012 |
Signaling networks in human pluripotent stem cells.
Topics: Activins; Animals; Cell Differentiation; Fibroblast Growth Factor 2; Humans; Insulin; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Pluripotent Stem Cells; Proto-Oncogene Proteins c-akt; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Wnt Signaling Pathway | 2013 |
Activin and TGF-β effects on brain development and neural stem cells.
Topics: Activins; Animals; Brain; Humans; Nerve Tissue Proteins; Neural Stem Cells; Neurogenesis; Neuroglia; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2012 |
The therapeutic potential of blocking the activin signalling pathway.
Topics: Activins; Animals; Antineoplastic Agents; Cachexia; Cell Proliferation; Humans; Musculoskeletal Diseases; Neoplasm Proteins; Neoplasms, Gonadal Tissue; Neuromuscular Diseases; Signal Transduction; Transforming Growth Factor beta | 2013 |
Strategies for exploring TGF-β signaling in Drosophila.
Topics: Activins; Animals; Developmental Biology; DNA-Binding Proteins; Drosophila; Gene Expression Regulation, Developmental; Phosphorylation; Signal Transduction; Transforming Growth Factor beta | 2014 |
Skeletal muscle is an endocrine organ.
Topics: Activins; Adipokines; Bone Morphogenetic Proteins; Brain-Derived Neurotrophic Factor; Collagen; Energy Metabolism; Exercise; Fibronectins; Follistatin; Humans; Inhibins; Interleukins; Muscle, Skeletal; Myostatin; Transforming Growth Factor beta | 2014 |
TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease.
Topics: Activin Receptors; Activins; Animals; Autophagy; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Humans; Hypertrophy; Mice, Knockout; Mice, Transgenic; Models, Biological; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Protein Isoforms; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2014 |
Transforming growth factor-β superfamily in obstructive lung diseases. more suspects than TGF-β alone.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; Lung; Lung Diseases, Obstructive; Transforming Growth Factor beta | 2015 |
Activin signalling and pre-eclampsia: from genetic risk to pre-symptomatic biomarker.
Topics: Activins; Biomarkers; Clinical Trials as Topic; Cytokines; Female; Genetic Predisposition to Disease; Humans; Inflammation; Oxidative Stress; Placenta; Polymorphism, Genetic; Pre-Eclampsia; Pregnancy; Risk Factors; Signal Transduction; Transforming Growth Factor beta | 2015 |
Bone and morphogenetic protein signalling and muscle mass.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; Muscle, Skeletal; Muscular Diseases; Myostatin; Signal Transduction; Transforming Growth Factor beta | 2015 |
Regulators of ovarian preantral follicle development.
Topics: Activins; Female; Follicle Stimulating Hormone; Gonadotropins; Humans; Oogenesis; Ovarian Follicle; Receptors, FSH; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta | 2015 |
The TGF-β superfamily in dendritic cell biology.
Topics: Activins; Bone Morphogenetic Proteins; Dendritic Cells; Gene Expression Regulation; Humans; Killer Cells, Natural; Ligands; Signal Transduction; T-Lymphocytes; Transforming Growth Factor beta | 2015 |
Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and Progression.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Brain Neoplasms; Disease Progression; Epithelial-Mesenchymal Transition; Glioblastoma; Humans; Immunomodulation; Left-Right Determination Factors; Neoplasm Invasiveness; Neovascularization, Pathologic; Nodal Protein; Signal Transduction; Transforming Growth Factor beta | 2015 |
Activin Receptor II Ligand Traps and Their Therapeutic Potential in Myelodysplastic Syndromes with Ring Sideroblasts.
Topics: Activin Receptors, Type II; Activins; Humans; Immunoglobulin Fc Fragments; Iron Overload; Myelodysplastic Syndromes; Phosphoproteins; Recombinant Fusion Proteins; RNA Splicing Factors; Transforming Growth Factor beta | 2016 |
Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Colorectal Neoplasms; Germ-Line Mutation; Homeostasis; Humans; Mice; Mice, Knockout; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2017 |
Immunoregulation by members of the TGFβ superfamily.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Gene Expression Regulation; Homeostasis; Humans; Immune System; Immunomodulation; Inflammation; Multigene Family; Neoplasms; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2016 |
TGF-β, Bone Morphogenetic Protein, and Activin Signaling and the Tumor Microenvironment.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; Neoplasms; Signal Transduction; Transforming Growth Factor beta; Tumor Microenvironment | 2017 |
Cardiokines as Modulators of Stress-Induced Cardiac Disorders.
Topics: Activins; Animals; Biomarkers; Fibroblast Growth Factors; Follistatin; Follistatin-Related Proteins; Growth Differentiation Factor 15; Heart Diseases; Humans; Inflammation; Interleukin-33; Myocardium; Myostatin; Paracrine Communication; Stress, Physiological; Transforming Growth Factor beta | 2017 |
TGF-β family co-receptor function and signaling.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; Models, Molecular; Protein Binding; Protein Domains; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2018 |
Activin receptor ligand traps in chronic kidney disease.
Topics: Activin Receptors; Activin Receptors, Type II; Activins; Anemia; Animals; Erythropoiesis; Hematinics; Humans; Immunoglobulin Fc Fragments; Ligands; Recombinant Fusion Proteins; Renal Insufficiency, Chronic; Transforming Growth Factor beta | 2018 |
Endocrine Regulation of Energy Balance by Drosophila TGF-β/Activins.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Carbohydrate Metabolism; Drosophila; Lipid Metabolism; Signal Transduction; Transforming Growth Factor beta | 2018 |
Perspectives of small molecule inhibitors of activin receptor‑like kinase in anti‑tumor treatment and stem cell differentiation (Review).
Topics: Activin Receptors; Activins; Animals; Cell Differentiation; Humans; Mesenchymal Stem Cells; Neoplasms; Signal Transduction; Small Molecule Libraries; Transforming Growth Factor beta | 2019 |
Principles of the activin receptor signaling pathway and its inhibition.
Topics: Activin Receptors; Activins; Animals; Humans; Signal Transduction; Transforming Growth Factor beta | 2021 |
Recent progress in drug development for fibrodysplasia ossificans progressiva.
Topics: Activins; Bone Morphogenetic Proteins; Drug Development; Humans; Ligands; Mutation; Myositis Ossificans; Ossification, Heterotopic; Transforming Growth Factor beta | 2022 |
Different Immunoregulation Roles of Activin A Compared With TGF-β.
Topics: Activins; Signal Transduction; Trans-Activators; Transforming Growth Factor beta | 2022 |
Bone morphogenetic proteins, activins, and growth and differentiation factors in tumor immunology and immunotherapy resistance.
Topics: Activins; Bone Morphogenetic Proteins; Cell Differentiation; Immunotherapy; Transforming Growth Factor beta | 2022 |
Inactivating the Uninhibited: The Tale of Activins and Inhibins in Pulmonary Arterial Hypertension.
Topics: Activins; Humans; Inhibins; Pulmonary Arterial Hypertension; Transforming Growth Factor beta | 2023 |
Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma.
Topics: Activins; Bone Morphogenetic Proteins; Carcinoma, Hepatocellular; Humans; Liver Cirrhosis; Liver Neoplasms; Membrane Proteins; Transforming Growth Factor beta | 2023 |
From bench to bedside: The promise of sotatercept in hematologic disorders.
Topics: Activins; Anemia; Bone Morphogenetic Proteins; Erythropoiesis; Growth Differentiation Factors; Humans; Prospective Studies; Recombinant Fusion Proteins; Transforming Growth Factor beta | 2023 |
1 trial(s) available for activins and transforming growth factor beta
| Article | Year |
|---|---|
Postexercise myostatin and activin IIb mRNA levels: effects of strength training.
Topics: Activins; Age Factors; Aged; Case-Control Studies; Exercise; Gene Expression; Humans; Male; Middle Aged; Muscle Contraction; Muscle, Skeletal; Myostatin; Quadriceps Muscle; RNA, Messenger; Time Factors; Transforming Growth Factor beta; Weight Lifting | 2007 |
547 other study(ies) available for activins and transforming growth factor beta
| Article | Year |
|---|---|
Expression of activins and TGF beta 1 and beta 2 RNAs in early postimplantation mouse embryos and uterine decidua.
Topics: Activins; Animals; Decidua; Ectoderm; Embryonic Induction; Endothelium, Vascular; Female; Gene Expression Regulation; Gestational Age; Inhibins; Mice; Mice, Inbred Strains; Nucleic Acid Hybridization; RNA; Transforming Growth Factor beta | 1992 |
Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation.
Topics: Activins; Amino Acid Sequence; Animals; Bone and Bones; Bone Development; Bone Morphogenetic Proteins; Cattle; Cells, Cultured; Chromatography, Gel; Cyanogen Bromide; Follicle Stimulating Hormone; Growth Substances; Hematopoiesis; In Vitro Techniques; Inhibins; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Peptide Fragments; Pituitary Gland; Proteins; Rats; Rats, Inbred Strains; Transforming Growth Factor beta | 1992 |
Activin-A modulates gonadotropin-releasing hormone secretion from a gonadotropin-releasing hormone-secreting neuronal cell line.
Topics: Activins; Cell Line; Clone Cells; Gonadotropin-Releasing Hormone; Inhibins; Neurons; Radioimmunoassay; Reproduction; Transforming Growth Factor beta | 1991 |
Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone.
Topics: Activins; Animals; Binding, Competitive; Cell Division; Cells, Cultured; Collagen; DNA; Dose-Response Relationship, Drug; Drug Synergism; Inhibins; Osteoblasts; Parathyroid Hormone; Protein Biosynthesis; Rats; Receptors, Cell Surface; Time Factors; Transforming Growth Factor beta | 1991 |
Inhibition by vitamin D3 of erythroid differentiation of human leukemia line cells induced by transforming growth factor beta or erythroid differentiation factor (activin A).
Topics: Activins; Calcitriol; Cell Differentiation; Dexamethasone; Erythroid Precursor Cells; Humans; Inhibins; Leukemia, Experimental; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Tumor Cells, Cultured | 1991 |
Transforming growth factor-beta and activin inhibit basal secretion of prolactin in a pituitary monolayer culture system.
Topics: Activins; Animals; Cells, Cultured; DNA Replication; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Growth Hormone; In Vitro Techniques; Inhibins; Pituitary Gland, Anterior; Prolactin; Radioimmunoassay; Rats; Rats, Inbred Strains; Recombinant Proteins; Transforming Growth Factor beta | 1991 |
Transforming growth factor-beta: role in mediating serum-induced endothelin production by vascular endothelial cells.
Topics: Activins; Animals; Blood Physiological Phenomena; Cells, Cultured; Endothelins; Endothelium, Vascular; Follistatin; Glycoproteins; Immune Sera; Inhibins; Transforming Growth Factor beta | 1991 |
Turned on by activin. Growth and Differentiation Factors and Development: a UCLA symposium, Steamboat Springs, CO, USA, March 31-April 7, 1990.
Topics: Activins; Animals; Cell Differentiation; Cell Division; Epidermal Growth Factor; Fibroblast Growth Factors; Growth Substances; Humans; Inhibins; Platelet-Derived Growth Factor; Transforming Growth Factor beta | 1990 |
Transforming growth factor-alpha and -beta are potent and effective inhibitors of GH4 pituitary tumor cell proliferation.
Topics: Activins; Animals; Cell Adhesion; Cell Count; Cell Division; DNA; Inhibins; Interphase; Mitosis; Phorbol 12,13-Dibutyrate; Pituitary Neoplasms; Prolactin; Protein Kinase C; Rats; Recombinant Proteins; S Phase; Tetradecanoylphorbol Acetate; Transforming Growth Factor alpha; Transforming Growth Factor beta; Tumor Cells, Cultured | 1991 |
Specific roles of activin/inhibin in human erythropoiesis in vitro.
Topics: Activins; Cell Differentiation; Cell Line; Cells, Cultured; Colony-Forming Units Assay; Erythropoiesis; Globins; Hematopoietic Stem Cells; Humans; Inhibins; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macromolecular Substances; Models, Biological; Multigene Family; RNA, Messenger; Transforming Growth Factor beta | 1991 |
Endothelin releasing activity in calf serum and porcine follicular fluid.
Topics: Activins; Animals; Aorta; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Endothelins; Endothelium, Vascular; Female; Follicular Fluid; Inhibins; Swine; Transforming Growth Factor beta | 1990 |
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.
Topics: Activins; Animals; Base Sequence; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Ectoderm; Embryonic Induction; Gastrula; Gene Expression Regulation, Developmental; Inhibins; Mesoderm; Molecular Sequence Data; Mutation; Neural Pathways; Oocytes; Proteins; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1995 |
Bone morphogenetic proteins induce differentiation in astrocyte lineage cells.
Topics: Activins; Animals; Astrocytes; Bone Morphogenetic Proteins; Carrier Proteins; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cells, Cultured; Glial Fibrillary Acidic Protein; Growth Substances; Hyaluronan Receptors; Inhibins; Mice; Models, Neurological; Proteins; Receptors, Cell Surface; Receptors, Lymphocyte Homing; Transforming Growth Factor beta | 1994 |
In vitro regulation of rat Sertoli cell inhibin messenger RNA levels by transforming growth factor-beta 1 and tumour necrosis factor alpha.
Topics: Activins; Animals; Blotting, Northern; Bucladesine; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Growth Substances; Inhibins; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sertoli Cells; Time Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 1995 |
A nodal-related gene defines a physical and functional domain within the Spemann organizer.
Topics: Actins; Activins; Amino Acid Sequence; Animals; Blastocyst; Carrier Proteins; Cell Differentiation; Cloning, Molecular; Epithelium; Gastrula; Gene Expression Regulation, Developmental; Inhibins; Mesoderm; Molecular Sequence Data; Morphogenesis; Proteins; Receptors, Transforming Growth Factor beta; RNA, Messenger; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1995 |
TGF-beta completely blocks the formation of small-cell colonies: effects of mito-inhibitory factors on the proliferation of primary cultured rat hepatocytes.
Topics: Activins; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Inhibins; Interleukin-1; Interleukin-6; Liver; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta | 1995 |
A molecular pathway determining left-right asymmetry in chick embryogenesis.
Topics: Activins; Animals; Cell Differentiation; Cell Polarity; Chick Embryo; Embryonic Induction; Functional Laterality; Gastrula; Gene Expression; Heart; Hedgehog Proteins; In Situ Hybridization; Inhibins; Proteins; Trans-Activators; Transforming Growth Factor beta | 1995 |
Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function.
Topics: Activins; Animals; Aromatase; Biological Assay; Blastocyst; Blotting, Northern; Blotting, Western; Cell Line; Cells, Cultured; Culture Media, Conditioned; Follicle Stimulating Hormone; Inhibins; Male; Metribolone; Mice; Rats; Rats, Wistar; Receptors, Androgen; Recombinant Proteins; RNA; Sertoli Cells; Transforming Growth Factor beta; Xenopus laevis | 1993 |
Stimulation of circus movement by activin, bFGF and TGF-beta 2 in isolated animal cap cells of Xenopus laevis.
Topics: Activins; Animals; Cell Movement; Cytoplasm; Embryo, Nonmammalian; Fibroblast Growth Factor 2; Growth Substances; Inhibins; Morphogenesis; Rotation; Stimulation, Chemical; Transforming Growth Factor beta; Xenopus laevis | 1995 |
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects.
Topics: Activin Receptors; Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cells, Cultured; Chlorocebus aethiops; Embryonic Induction; Erythropoiesis; Follicle Stimulating Hormone; Follistatin; Glycoproteins; Growth Inhibitors; In Vitro Techniques; Inhibins; Mesoderm; Mink; Pituitary Gland, Anterior; Protein Binding; Proteins; Receptors, Growth Factor; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta; Xenopus Proteins | 1995 |
Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts.
Topics: 3-Hydroxysteroid Dehydrogenases; 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Activins; Dihydrotestosterone; Fibroblasts; Finasteride; Gene Expression Regulation, Enzymologic; Humans; Inhibins; Male; Recombinant Proteins; Scrotum; Transforming Growth Factor beta | 1995 |
Molecular characterization of a type I serine-threonine kinase receptor for TGF-beta and activin in the rat pituitary tumor cell line GH3.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cloning, Molecular; Gene Expression; Inhibins; Molecular Sequence Data; Organ Specificity; Pituitary Gland; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Rats; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transforming Growth Factor beta; Tumor Cells, Cultured | 1995 |
A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-beta.
Topics: Activins; Animals; Base Sequence; Cells, Cultured; DNA Primers; Inhibins; Membrane Proteins; Molecular Sequence Data; Pituitary Neoplasms; Polymerase Chain Reaction; Protein Binding; Rats; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 1995 |
Cloning of a new member of the TGF-beta family: a putative new activin beta C chain.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Chickens; Cloning, Molecular; DNA Primers; Drosophila; Growth Substances; Humans; Inhibins; Macromolecular Substances; Mice; Molecular Sequence Data; Phylogeny; Polymerase Chain Reaction; Sequence Homology, Amino Acid; Transforming Growth Factor beta; Xenopus | 1995 |
Bone morphogenetic proteins inhibit proliferation, induce reversible differentiation and prevent cell death in astrocyte lineage cells.
Topics: Activins; Animals; Astrocytes; Bone Morphogenetic Proteins; Cell Differentiation; Cell Division; Cell Survival; Cells, Cultured; Glial Fibrillary Acidic Protein; Growth Substances; Inhibins; Mice; Phenotype; Proteins; Transforming Growth Factor beta | 1994 |
TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Activins; Animals; Base Sequence; Cells, Cultured; DNA Primers; Gene Expression; Glial Cell Line-Derived Neurotrophic Factor; In Vitro Techniques; Inhibins; Mesencephalon; Molecular Sequence Data; Nerve Growth Factors; Nerve Tissue Proteins; Rats; Receptors, Dopamine; RNA, Messenger; Transforming Growth Factor beta; Tyrosine 3-Monooxygenase | 1995 |
Functional analysis of activins during mammalian development.
Topics: Activins; Animals; Cell Line; Embryonic and Fetal Development; Growth Substances; Inhibins; Mice; Mice, Inbred C57BL; Mutation; Palate; Skull; Transforming Growth Factor beta | 1995 |
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4.
Topics: Activin Receptors; Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Humans; Inhibins; Mice; Phylogeny; Protein Serine-Threonine Kinases; Proteins; Receptors, Growth Factor; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection; Transforming Growth Factor beta | 1994 |
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
Topics: Activin Receptors; Activins; Animals; Bone Morphogenetic Proteins; Embryonic Induction; Follistatin; Glycoproteins; Inhibins; Mesoderm; Microinjections; Proteins; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1994 |
Effects of transforming growth factors and activin-A on in vitro porcine oocyte maturation.
Topics: Activins; Alcohols; Animals; Epidermal Growth Factor; Female; Gap Junctions; Growth Substances; Heptanol; In Vitro Techniques; Inhibins; Oocytes; Swine; Transforming Growth Factor alpha; Transforming Growth Factor beta | 1994 |
Characterization of type I receptors for transforming growth factor-beta and activin.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Bone Morphogenetic Protein Receptors, Type I; Cell Line; Inhibins; Ligands; Mice; Molecular Sequence Data; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 1994 |
Characterization of immortalized mouse granulosa cell lines.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Activins; Animals; Cell Division; Cell Line, Transformed; Culture Media, Conditioned; Female; Granulosa Cells; Growth Substances; Inhibins; Karyotyping; Mice; Prostaglandins; Proto-Oncogene Proteins c-myc; Steroids; Transforming Growth Factor beta | 1993 |
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Amino Acid Sequence; Animals; Base Sequence; Cell Division; Cell Line; Chlorocebus aethiops; DNA Primers; DNA, Complementary; Gene Expression; Humans; Inhibins; Kidney; Luciferases; Lung; Mink; Molecular Sequence Data; Mutagenesis; Polymerase Chain Reaction; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Sequence Homology, Amino Acid; Swine; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 1994 |
The transforming growth factor beta type II receptor can replace the activin type II receptor in inducing mesoderm.
Topics: Activin Receptors; Activins; Animals; Embryo, Nonmammalian; Inhibins; Mesoderm; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Xenopus laevis | 1994 |
Inhibition of vascular endothelial cell growth by activin-A.
Topics: Activin Receptors; Activins; Base Sequence; Cell Division; Cloning, Molecular; DNA; DNA Primers; Endothelium, Vascular; Gene Expression; Humans; Inhibins; Molecular Sequence Data; Protein Serine-Threonine Kinases; Receptors, Growth Factor; RNA, Messenger; Transforming Growth Factor beta | 1993 |
Determination of type I receptor specificity by the type II receptors for TGF-beta or activin.
Topics: Activin Receptors; Activins; Base Sequence; DNA Primers; Growth Substances; Humans; Inhibins; Molecular Sequence Data; Precipitin Tests; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Signal Transduction; Transfection; Transforming Growth Factor beta | 1993 |
Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors.
Topics: Activin Receptors; Activins; Cloning, Molecular; DNA Primers; DNA, Complementary; Gene Expression Regulation; Humans; Inhibins; Ligands; Macromolecular Substances; Molecular Sequence Data; Protein Serine-Threonine Kinases; Receptors, Cell Surface; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Species Specificity; Transforming Growth Factor beta | 1993 |
Activin A induces apoptotic cell death.
Topics: Activins; Animals; Apoptosis; Cell Line; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Follistatin; Glycoproteins; Growth Substances; Humans; Hybridomas; Inhibins; Interleukin-6; Kinetics; Lymphoma; Mice; Multiple Myeloma; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Recombinant bone morphogenetic protein-4, transforming growth factor-beta 1, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro.
Topics: Activins; Animals; Binding, Competitive; Blotting, Northern; Bone Morphogenetic Proteins; Cartilage, Articular; Cattle; Cell Division; Cell Membrane; DNA; Growth Substances; Inhibins; Iodine Radioisotopes; Kinetics; Mitosis; Phenotype; Proteins; Proteoglycans; Recombinant Proteins; Sulfates; Thymidine; Transforming Growth Factor beta | 1994 |
Activin induces cell death in hepatocytes in vivo and in vitro.
Topics: Activins; Animals; Cell Death; Cell Separation; Female; Growth Substances; Inhibins; Liver; Time Factors; Transforming Growth Factor beta | 1993 |
Modulation of activin expression by type beta transforming growth factors.
Topics: Activins; Animals; Blotting, Northern; Cell Line; Gene Expression Regulation, Neoplastic; Inhibins; Mice; RNA, Messenger; Teratoma; Transcription, Genetic; Transforming Growth Factor beta | 1993 |
Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes.
Topics: Activins; Animals; Base Sequence; Cell Division; Cells, Cultured; DNA; DNA Replication; Epidermal Growth Factor; Follistatin; Gene Expression; Glycoproteins; Hepatocyte Growth Factor; In Vitro Techniques; Inhibins; Liver; Molecular Sequence Data; Oligodeoxyribonucleotides; Rats; Recombinant Proteins; Time Factors; Transforming Growth Factor beta | 1993 |
A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Bone Morphogenetic Proteins; Carcinoma, Hepatocellular; Cell Line; Cloning, Molecular; DNA, Neoplasm; Gene Expression; Growth Substances; Humans; Inhibins; Liver; Liver Neoplasms; Molecular Sequence Data; Moths; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Proteins; RNA, Neoplasm; Sequence Homology, Amino Acid; Substrate Specificity; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 1993 |
Isolation of rat blood lymphocytes using a two-step Percoll density gradient. Effect of activin (erythroid differentiation factor) on peripheral T lymphocyte proliferation in vitro.
Topics: Activins; Animals; Cell Differentiation; Cell Separation; Centrifugation, Density Gradient; Growth Substances; Inhibins; Lymphocyte Activation; Male; Phytohemagglutinins; Povidone; Rats; Silicon Dioxide; T-Lymphocytes; Transforming Growth Factor beta | 1993 |
Effects of activin-A, inhibin-A, and transforming growth factor-beta 1 on stage-specific deoxyribonucleic acid synthesis during rat seminiferous epithelial cycle.
Topics: Activins; Animals; Culture Techniques; DNA; Inhibins; Male; Rats; Rats, Sprague-Dawley; Seminiferous Tubules; Spermatogenesis; Time Factors; Transforming Growth Factor beta | 1993 |
Regulation of inhibin secretion in human placental cell culture by epidermal growth factor, transforming growth factors, and activin.
Topics: Activins; Cells, Cultured; Chorionic Gonadotropin; Drug Interactions; Epidermal Growth Factor; Female; Humans; Inhibins; Placenta; Placental Lactogen; Pregnancy; Testosterone; Time Factors; Transforming Growth Factor beta; Transforming Growth Factors | 1993 |
Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.
Topics: Activins; Base Sequence; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Growth Substances; Humans; Inhibins; Molecular Sequence Data; Receptors, Estrogen; Receptors, Transforming Growth Factor beta; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 1995 |
Regulation of the activin-binding protein follistatin cultured human luteinizing granulosa cells: characterization of the effects of follicle stimulating hormone, prostaglandin E2, and different growth factors.
Topics: Activins; Blotting, Northern; Cells, Cultured; Cycloheximide; Dinoprostone; Epidermal Growth Factor; Female; Follicle Stimulating Hormone; Follistatin; Gene Expression Regulation; Glycoproteins; Granulosa Cells; Growth Substances; Humans; Inhibins; Recombinant Proteins; RNA, Messenger; Time Factors; Transforming Growth Factor beta | 1995 |
Activin A and transforming growth factor-beta stimulate heart formation in axolotls but not rescue cardiac lethal mutants.
Topics: Activins; Ambystoma; Animals; Cell Differentiation; Embryo, Nonmammalian; Epidermal Growth Factor; Genes, Lethal; Heart; Inhibins; Microscopy, Electron; Mutation; Myocardium; Organ Culture Techniques; Platelet-Derived Growth Factor; Transforming Growth Factor beta | 1995 |
The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Alkyl and Aryl Transferases; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Humans; Inhibins; Ligands; Molecular Sequence Data; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Signal Transduction; Transferases; Transforming Growth Factor beta | 1996 |
Transforming growth factor-beta 1 and -beta 2 induce inhibin and activin beta B-subunit messenger ribonucleic acid levels in cultured human granulosa-luteal cells.
Topics: Activins; Base Sequence; Cells, Cultured; Culture Media; Female; Gene Expression; Granulosa Cells; Humans; Inhibins; Luteal Cells; Molecular Sequence Data; RNA, Messenger; Transforming Growth Factor beta | 1996 |
Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas.
Topics: Activin Receptors; Activins; Adenoma; Adolescent; Adult; Alternative Splicing; Amino Acid Sequence; Base Sequence; Gene Expression; Humans; Inhibins; Middle Aged; Molecular Sequence Data; Pituitary Neoplasms; Polymerase Chain Reaction; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta | 1996 |
MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
Topics: Activins; Alleles; Animals; Bone Morphogenetic Proteins; Cell Nucleus; Cells, Cultured; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Epithelium; Growth Substances; Inhibins; Ligands; Mammals; Mink; Molecular Sequence Data; Mutation; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Repressor Proteins; Sequence Homology, Amino Acid; Signal Transduction; Smad Proteins; Smad1 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 1996 |
Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Cell Communication; Diffusion; Embryo, Nonmammalian; Embryonic Induction; Extracellular Space; Glycoproteins; Inhibins; Mesoderm; Molecular Sequence Data; Muscles; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1996 |
Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.
Topics: Activins; Animals; Base Sequence; Blastocyst; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Genes, Homeobox; Growth Substances; Inhibins; Mesoderm; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Fibroblast Growth Factor; Transcription, Genetic; Transforming Growth Factor beta; Xenopus | 1995 |
A transcriptional partner for MAD proteins in TGF-beta signalling.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Inhibins; Molecular Sequence Data; Signal Transduction; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Turner Syndrome; Xenopus; Xenopus Proteins | 1996 |
Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.
Topics: Activins; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Embryo, Nonmammalian; Embryonic Induction; Growth Substances; Humans; Inhibins; Mesoderm; Nerve Growth Factors; Phosphorylation; Repressor Proteins; Signal Transduction; Smad Proteins; Smad1 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transfection; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1996 |
Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes.
Topics: Activins; Adolescent; Adult; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cartilage; Cartilage, Articular; Cell Differentiation; Cell Division; Cells, Cultured; Child, Preschool; Collagen; Female; Fetus; Humans; Infant, Newborn; Inhibins; Male; Proteoglycans; Recombinant Proteins; Sulfur Radioisotopes; Transforming Growth Factor beta | 1996 |
Activin-A stimulates, while transforming growth factor beta 1 inhibits, chorionic gonadotrophin production and aromatase activity in cultured human placental trophoblasts.
Topics: Activins; Aromatase; Cells, Cultured; Chorionic Gonadotropin; Female; Humans; Inhibins; Pregnancy; Transforming Growth Factor beta; Trophoblasts | 1996 |
Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; beta-Galactosidase; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Drosophila; Genes, myc; Genes, Reporter; Humans; I-kappa B Proteins; Inhibins; Luciferases; Lung; Mammals; Mice; Mink; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Nuclear Proteins; Oligodeoxyribonucleotides; Phosphoproteins; Phylogeny; Rats; Repressor Proteins; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Smad1 Protein; Transcription, Genetic; Transforming Growth Factor beta; Xenopus | 1996 |
Laterality defects in conjoined twins.
Topics: Activins; Animals; Chickens; Diseases in Twins; Embryonic Induction; Hedgehog Proteins; Humans; Inhibins; Nodal Protein; Proteins; Trans-Activators; Transforming Growth Factor beta; Twins, Conjoined | 1996 |
Signalling by TGF-beta family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activin.
Topics: Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; DNA-Binding Proteins; Fetal Proteins; Goosecoid Protein; Homeodomain Proteins; Inhibins; Mice; Nodal Signaling Ligands; Proteins; Receptors, Growth Factor; Recombinant Fusion Proteins; Repressor Proteins; Signal Transduction; T-Box Domain Proteins; Transcription Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1996 |
Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells.
Topics: Activin Receptors; Activins; Androgens; Cell Division; Drug Resistance; Follistatin; Glycoproteins; Humans; Inhibins; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Growth Factor; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured | 1996 |
Molecular cloning of the mouse activin beta E subunit gene.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary; Mice; Molecular Sequence Data; Oligopeptides; Peptides; Sequence Homology, Amino Acid; Species Specificity; Transforming Growth Factor beta | 1996 |
Synergistic effect of BMP-2 and ascorbate on the phenotypic expression of osteoblastic MC3T3-E1 cells.
Topics: Activins; Alkaline Phosphatase; Animals; Ascorbic Acid; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cell Size; Cells, Cultured; Collagen; Drug Synergism; Extracellular Matrix; Inhibins; Mice; Osteoblasts; Receptors, Cell Surface; Skull; Transforming Growth Factor beta | 1996 |
Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos.
Topics: Activins; Animals; Base Sequence; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; DNA-Binding Proteins; Embryo, Nonmammalian; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Inhibins; Lip; Molecular Sequence Data; Promoter Regions, Genetic; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Sequence Homology, Nucleic Acid; Transcription, Genetic; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 1996 |
Activin signalling has a necessary function in Xenopus early development.
Topics: Activin Receptors; Activins; Animals; Embryo, Nonmammalian; Embryonic Induction; Fibroblast Growth Factors; Inhibins; Mice; Mice, Knockout; Platelet-Derived Growth Factor; Receptors, Growth Factor; Transforming Growth Factor beta; Xenopus | 1997 |
Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Cell Differentiation; Cell Division; Erythrocytes; Gene Expression; Hemoglobins; Humans; Inhibins; Isopropyl Thiogalactoside; Kinetics; Leukemia, Erythroblastic, Acute; Ligands; Protein Binding; Receptors, Growth Factor; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 1997 |
Induction of the primary dorsalizing center in Xenopus by the Wnt/GSK/beta-catenin signaling pathway, but not by Vg1, Activin or Noggin.
Topics: Activins; Animals; beta Catenin; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cytoskeletal Proteins; DNA Primers; DNA-Binding Proteins; Embryo, Nonmammalian; Embryonic Induction; Female; Glycogen Synthase Kinase 3; Glycoproteins; Goosecoid Protein; Homeodomain Proteins; Inhibins; Models, Biological; Polymerase Chain Reaction; Protein Biosynthesis; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Repressor Proteins; Signal Transduction; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 1997 |
Activin inhibition of estradiol and progesterone production in porcine granulosa cells.
Topics: Activins; Animals; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Growth Substances; Inhibins; Progesterone; Radioimmunoassay; Swine; Time Factors; Transforming Growth Factor beta | 1997 |
DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells.
Topics: Activins; Alternative Splicing; Amino Acid Sequence; Base Sequence; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Breast Neoplasms; Cell Division; DNA Primers; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Gene Deletion; Genes, Tumor Suppressor; Humans; Inhibins; Luciferases; Molecular Sequence Data; Pancreatic Neoplasms; Polymerase Chain Reaction; Recombinant Fusion Proteins; Repressor Proteins; Sequence Deletion; Sequence Homology, Amino Acid; Smad4 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1997 |
Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cells.
Topics: Activins; Animals; Animals, Newborn; Astrocytes; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Cell Cycle; Cell Differentiation; Cell Lineage; Central Nervous System; Dose-Response Relationship, Drug; Gene Expression Regulation, Developmental; Glial Cell Line-Derived Neurotrophic Factor; Glial Fibrillary Acidic Protein; Inhibins; Nerve Growth Factors; Nerve Tissue Proteins; Neuroprotective Agents; Oligodendroglia; Rats; Receptors, Cell Surface; Receptors, Growth Factor; Stem Cells; Time Factors; Transforming Growth Factor beta | 1997 |
A vegetally localized T-box transcription factor in Xenopus eggs specifies mesoderm and endoderm and is essential for embryonic mesoderm formation.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; DNA-Binding Proteins; Embryo, Nonmammalian; Embryonic Induction; Endoderm; Fibroblast Growth Factors; Gastrula; Gene Expression Regulation, Developmental; Gene Library; In Situ Hybridization; Inhibins; Mesoderm; Molecular Sequence Data; Ovum; RNA, Messenger; Sequence Homology, Amino Acid; T-Box Domain Proteins; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 1997 |
Assessment of the role of activin A and transforming growth factor beta in the regulation of AML12 cell growth.
Topics: Activin Receptors; Activins; Animals; Cell Division; Cell Line; DNA; DNA, Complementary; Inhibins; Liver; Mice; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Transfection; Transforming Growth Factor beta | 1997 |
Opposing effects of activin A and follistatin on developing skeletal muscle cells.
Topics: Activins; Animals; Cell Nucleus; Cells, Cultured; Chick Embryo; Creatine Kinase; DNA-Binding Proteins; Fibroblast Growth Factors; Fluorescent Antibody Technique, Indirect; Follistatin; Gene Expression; Glycoproteins; Inhibins; Muscle Proteins; Muscle, Skeletal; MyoD Protein; Myogenic Regulatory Factor 5; RNA, Messenger; Trans-Activators; Transforming Growth Factor beta | 1997 |
Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells.
Topics: Activin Receptors; Activins; Animals; CHO Cells; COS Cells; Cricetinae; Gene Expression; Genes, Immediate-Early; Inhibins; Mice; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Receptors, Growth Factor; Signal Transduction; Transforming Growth Factor beta | 1997 |
Cell density-dependent apoptosis in HL-60 cells, which is mediated by an unknown soluble factor, is inhibited by transforming growth factor beta1 and overexpression of Bcl-2.
Topics: Activins; Apoptosis; Caspase 1; Caspase 3; Caspases; Cell Count; Cell Division; Culture Media, Conditioned; Cysteine Endopeptidases; HL-60 Cells; Humans; Hydrogen-Ion Concentration; Inhibins; Oligopeptides; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Transforming Growth Factor beta | 1997 |
Activin is a local regulator of human cytotrophoblast cell differentiation.
Topics: Activins; Animals; Cell Differentiation; Cell Division; Cell Movement; Enzyme Activation; Enzyme Induction; Female; Fibronectins; Follistatin; Gelatinases; Glycoproteins; Humans; Inhibins; Matrix Metalloproteinase 2; Metalloendopeptidases; Mice; Pregnancy; Signal Transduction; Transforming Growth Factor beta; Trophoblasts | 1997 |
Activin has direct long-range signalling activity and can form a concentration gradient by diffusion.
Topics: Activins; Animals; Blastocyst; Cell Differentiation; Diffusion; DNA-Binding Proteins; Fetal Proteins; Growth Substances; In Situ Hybridization; Inhibins; Mesoderm; RNA, Messenger; Signal Transduction; T-Box Domain Proteins; Transcription Factors; Transforming Growth Factor beta; Xenopus | 1997 |
Expression of TGF-beta superfamily receptors in dental pulp.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Blotting, Northern; Bone Morphogenetic Proteins; Cattle; Cloning, Molecular; Dental Pulp; DNA Primers; DNA, Complementary; Gene Expression Regulation; Gene Expression Regulation, Developmental; Growth Substances; Incisor; Inhibins; Molecular Sequence Data; Odontogenesis; Poly A; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; RNA; RNA, Messenger; Time Factors; Transcription, Genetic; Transforming Growth Factor beta; Wound Healing | 1997 |
A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord.
Topics: Activins; Animals; Biomarkers; Body Patterning; Bone Morphogenetic Proteins; Carrier Proteins; Cell Differentiation; Chick Embryo; Ectoderm; Embryonic Induction; Epidermis; Follistatin; Gene Expression Regulation, Developmental; Glycoproteins; Homeodomain Proteins; Inhibins; Interneurons; Molecular Sequence Data; Neural Crest; Notochord; Proteins; Rats; Signal Transduction; Spinal Cord; Transforming Growth Factor beta | 1997 |
Osteogenic protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2-like sequence and requires an adjacent AP-1 sequence.
Topics: Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line; Collagen; DNA-Binding Proteins; Fetus; Inhibins; MEF2 Transcription Factors; Mice; Myogenic Regulatory Factors; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Rats; Skull; Transcription Factor AP-1; Transcription Factors; Transfection; Transforming Growth Factor beta | 1997 |
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
Topics: Activin Receptors, Type I; Activins; Animals; Binding Sites; Cell Nucleus; COS Cells; DNA; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Deletion; Genes, Tumor Suppressor; Humans; Inhibins; Molecular Sequence Data; Nerve Growth Factors; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Signal Transduction; Smad Proteins; Smad1 Protein; Smad2 Protein; Smad4 Protein; Structure-Activity Relationship; Trans-Activators; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenopus; Xenopus Proteins | 1997 |
Cellular interpretation of multiple TGF-beta signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads.
Topics: Activins; Animals; Base Sequence; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; DNA Primers; DNA-Binding Proteins; Female; Goosecoid Protein; Homeodomain Proteins; Inhibins; Intracellular Fluid; Male; Nerve Growth Factors; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Cell Surface; Receptors, Growth Factor; Repressor Proteins; Signal Transduction; Smad Proteins; Smad2 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1997 |
Regulation of the expression of follistatin in rat hepatocytes.
Topics: Activins; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Epidermal Growth Factor; Follistatin; Gene Expression Regulation; Glucagon; Glycoproteins; Growth Substances; Inhibins; Liver; Male; Phenylephrine; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transforming Growth Factor beta | 1997 |
Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12.
Topics: Abnormalities, Multiple; Activins; Amino Acid Isomerases; Animals; Brain; Cardiomyopathy, Dilated; Carrier Proteins; DNA-Binding Proteins; Female; Fetal Death; Gene Deletion; Heart Defects, Congenital; Heart Septal Defects; Heat-Shock Proteins; Inhibins; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Tacrolimus Binding Proteins; Transforming Growth Factor beta | 1998 |
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Topics: Activins; Cell Division; Colorectal Neoplasms; DNA Primers; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Deletion; Genes, Tumor Suppressor; Humans; Inhibins; Nerve Growth Factors; Polymerase Chain Reaction; Recombination, Genetic; Restriction Mapping; Signal Transduction; Smad Proteins; Smad4 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Xenopus Proteins | 1998 |
Expression of activin A is increased in cirrhotic and fibrotic rat livers.
Topics: Activins; Adipocytes; Animals; Cells, Cultured; Collagen; DNA; Fibroblasts; Inhibins; Liver; Liver Cirrhosis, Experimental; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 1998 |
Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blotting, Northern; Cell Transformation, Neoplastic; COS Cells; DNA-Binding Proteins; Exons; Humans; Inhibins; Introns; Molecular Sequence Data; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta | 1998 |
The left-right coordinator: the role of Vg1 in organizing left-right axis formation.
Topics: Activins; Animals; Carrier Proteins; Embryo, Nonmammalian; Embryonic Induction; Follistatin; Gene Expression Regulation, Developmental; Glycoproteins; Heart; Inhibins; Protein Biosynthesis; Proteins; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1998 |
Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro.
Topics: Activins; Animals; Antibodies, Monoclonal; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Separation; Flow Cytometry; Fluorescent Antibody Technique; Fluorescent Dyes; Inhibins; Killer Cells, Natural; Lymphocyte Activation; Lymphocyte Count; Lymphocytes; Male; Rats; Rats, Sprague-Dawley; Testis; Transforming Growth Factor beta | 1998 |
Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies.
Topics: Activins; Arthritis, Rheumatoid; Chondrocytes; Humans; Inhibins; Interferon-gamma; Interleukin-1; Interleukin-6; Osteoarthritis; Synovial Fluid; Synovial Membrane; Transforming Growth Factor beta | 1998 |
Structure and expression of activin genes in rainbow trout.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Cloning, Molecular; DNA Primers; DNA, Complementary; Gene Expression; Genome; Inhibins; Molecular Sequence Data; Oncorhynchus mykiss; Polymerase Chain Reaction; RNA; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tissue Distribution; Transforming Growth Factor beta | 1998 |
Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line.
Topics: Activin Receptors; Activins; Animals; Cells, Cultured; COS Cells; DNA-Binding Proteins; Fluorescent Antibody Technique; Humans; Inhibins; Keratinocytes; Phosphorylation; Precipitin Tests; Receptors, Growth Factor; Signal Transduction; Smad2 Protein; Smad3 Protein; Trans-Activators; Transfection; Transforming Growth Factor beta | 1998 |
Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene.
Topics: Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; Humans; Inhibins; Mink; Mutagenesis, Site-Directed; Nuclear Proteins; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Protein Binding; Smad3 Protein; Smad4 Protein; Smad7 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos.
Topics: Activins; Amino Acid Sequence; Animals; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Dimerization; DNA, Complementary; Embryonic Induction; Gene Expression Regulation, Developmental; Genes, Dominant; Hematopoiesis; Mesoderm; Microinjections; Molecular Sequence Data; Protein Multimerization; RNA, Messenger; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 1998 |
The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Cloning, Molecular; Cytokines; Embryo, Nonmammalian; Embryonic Development; Gene Expression Regulation, Developmental; Inhibins; Intercellular Signaling Peptides and Proteins; Molecular Sequence Data; Neural Crest; Nodal Signaling Ligands; Oocytes; Proteins; Sequence Homology, Amino Acid; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1998 |
Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer.
Topics: Activins; Base Sequence; Bone Morphogenetic Proteins; DNA; DNA-Binding Proteins; Enhancer Elements, Genetic; Inhibins; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Smad3 Protein; Trans-Activators; Transcriptional Activation; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2.
Topics: Activins; Amino Acid Sequence; Animals; DNA-Binding Proteins; DNA, Recombinant; Forkhead Transcription Factors; Gene Expression Regulation; Goosecoid Protein; Homeodomain Proteins; Humans; Inhibins; Macromolecular Substances; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Repressor Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Smad2 Protein; Smad3 Protein; Trans-Activators; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenopus laevis; Xenopus Proteins | 1998 |
Characterization of human FAST-1, a TGF beta and activin signal transducer.
Topics: Activins; Amino Acid Sequence; Animals; Cloning, Molecular; Consensus Sequence; DNA; DNA-Binding Proteins; DNA, Neoplasm; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Inhibins; Macromolecular Substances; Mice; Mice, Nude; Molecular Sequence Data; Nerve Growth Factors; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; Smad Proteins; Smad2 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Xenopus Proteins | 1998 |
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line; DNA-Binding Proteins; Drug Synergism; Epidermal Growth Factor; Epithelial Cells; Gene Expression; Humans; Inhibins; Keratinocytes; Lung; Lung Neoplasms; Mink; RNA, Messenger; Signal Transduction; Smad6 Protein; Smad7 Protein; Tetradecanoylphorbol Acetate; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured | 1998 |
Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells.
Topics: Activins; Animals; Apoptosis; B-Lymphocytes; Cell Cycle; Cell Division; Cell Line; DNA-Binding Proteins; G1 Phase; Growth Substances; Hybridomas; Inhibins; Kinetics; Mice; Recombinant Proteins; RNA, Messenger; Signal Transduction; Smad7 Protein; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 1998 |
Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis.
Topics: Activins; Amino Acid Sequence; Animals; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Embryo, Nonmammalian; Embryonic Induction; Gene Expression; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; Inhibins; Mesoderm; Molecular Sequence Data; Nervous System; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Smad6 Protein; Trans-Activators; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1998 |
XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.
Topics: Activins; Animals; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Embryo, Nonmammalian; Gene Deletion; Gene Expression; Gene Expression Regulation, Developmental; Inhibins; Mesoderm; Muscles; Mutation; Notochord; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1998 |
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; DNA-Binding Proteins; Inhibins; Mice; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Signal Transduction; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad8 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factors; Tumor Cells, Cultured; Xenopus Proteins | 1998 |
Transforming growth factor-beta superfamily members expressed in rat incisor pulp.
Topics: Activins; Animals; Blotting, Northern; Bone Marrow; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Differentiation; Dental Pulp; Dentin; Gene Expression Regulation; Growth Differentiation Factor 1; Growth Differentiation Factor 5; Growth Differentiation Factor 6; Growth Substances; Incisor; Intercellular Signaling Peptides and Proteins; Nerve Growth Factors; Nerve Tissue Proteins; Odontoblasts; Odontogenesis; Oligopeptides; Peptides; Rats; Rats, Inbred LEC; Transforming Growth Factor beta | 1998 |
Maintenance of asymmetric nodal expression in Xenopus laevis.
Topics: Activins; Animals; Body Patterning; Chick Embryo; Follistatin; Gene Expression Regulation, Developmental; Glycoproteins; Heart; Hedgehog Proteins; In Situ Hybridization; Inhibins; Mice; Nodal Protein; Notochord; Proteins; Signal Transduction; Trans-Activators; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 1998 |
Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Blastocyst; Body Patterning; Cell Differentiation; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; In Situ Hybridization; Inhibins; Left-Right Determination Factors; Mesoderm; Molecular Sequence Data; Phenotype; Receptors, Growth Factor; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins | 1999 |
FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; COS Cells; DNA-Binding Proteins; DNA, Complementary; Forkhead Transcription Factors; Gene Expression; Genes, Overlapping; Inhibins; Luciferases; Mammals; Mice; Molecular Sequence Data; Signal Transduction; Smad2 Protein; Smad3 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 1999 |
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
Topics: Activins; Animals; Antigens, CD; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cells, Cultured; COS Cells; Digitonin; Endoglin; Endothelium, Vascular; Humans; Inhibins; Protein Binding; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1 | 1999 |
Regulation of avian cardiac myogenesis by activin/TGFbeta and bone morphogenetic proteins.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Chick Embryo; Embryo, Nonmammalian; Embryonic Induction; Heart; Inhibins; Mesoderm; Transforming Growth Factor beta | 1998 |
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping.
Topics: Abnormalities, Multiple; Activins; Amino Acid Sequence; Animals; Body Patterning; Cell Communication; Digestive System; Gastrula; Gene Expression Regulation, Developmental; Genes, Homeobox; Heart; Homeobox Protein PITX2; Homeodomain Proteins; Inhibins; Intracellular Signaling Peptides and Proteins; Mice; Mice, Mutant Strains; Molecular Sequence Data; Morphogenesis; Nodal Protein; Nuclear Proteins; Paired Box Transcription Factors; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Transcription Factors; Transforming Growth Factor beta; Vertebrates; Xenopus; Xenopus Proteins; Zebrafish; Zebrafish Proteins | 1999 |
Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus.
Topics: Activin Receptors, Type I; Activins; Animals; COS Cells; DNA-Binding Proteins; Embryonic Development; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Inhibins; Morphogenesis; Mutation; Nerve Growth Factors; Phosphorylation; Receptors, Growth Factor; RNA, Messenger; Signal Transduction; Smad Proteins; Smad2 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1999 |
Activin and TGFbeta limit murine primordial germ cell proliferation.
Topics: Activin Receptors; Activins; Animals; Cell Differentiation; Cell Division; Cell Movement; Cells, Cultured; Embryonic and Fetal Development; Germ Cells; Histocytochemistry; Inhibins; Mice; Mice, Inbred Strains; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 1999 |
Proliferation and apoptosis in the human adrenal cortex during the fetal and perinatal periods: implications for growth and remodeling.
Topics: Activins; Adrenal Cortex; Aging; Apoptosis; Cell Division; Embryonic and Fetal Development; Fetus; Humans; Infant, Newborn; Inhibins; Transforming Growth Factor beta | 1999 |
Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1.
Topics: Activin Receptors; Activins; Animals; Antigens, CD; Bone Morphogenetic Proteins; Cell Line; COS Cells; Endoglin; Inhibins; Ligands; Protein Serine-Threonine Kinases; Proteoglycans; Rabbits; Receptors, Cell Surface; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction; Telangiectasia, Hereditary Hemorrhagic; Transforming Growth Factor beta; Vascular Cell Adhesion Molecule-1 | 1999 |
Control of digit formation by activin signalling.
Topics: Activin Receptors, Type II; Activins; Animals; Cell Death; Chick Embryo; Extremities; Follistatin; Glycoproteins; Inhibins; Morphogenesis; Receptors, Growth Factor; Signal Transduction; Transforming Growth Factor beta | 1999 |
Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells.
Topics: Activins; Animals; Apoptosis; B-Lymphocytes; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Division; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Humans; Inhibins; Mice; Phosphorylation; RNA, Messenger; Smad6 Protein; Smad7 Protein; Trans-Activators; Transforming Growth Factor beta | 1999 |
Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Amino Acid Sequence; Animals; Arabidopsis Proteins; Brain; DNA-Binding Proteins; Drosophila; Gene Expression Regulation, Developmental; In Situ Hybridization; Inhibins; Insect Proteins; Larva; Molecular Sequence Data; Phosphorylation; Plant Proteins; Receptors, Growth Factor; Sequence Homology, Amino Acid; Signal Transduction; Smad2 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 1999 |
Bone morphogenetic protein-2 enhances osteoclast formation mediated by interleukin-1alpha through upregulation of osteoclast differentiation factor and cyclooxygenase-2.
Topics: Activins; Animals; Bone Development; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Developmental; Indomethacin; Inhibins; Interleukin-1; Isoenzymes; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Nitrobenzenes; Osteoclasts; Prostaglandin-Endoperoxide Synthases; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; RNA, Messenger; Sulfonamides; Transforming Growth Factor beta; Up-Regulation | 1999 |
A comparative study on transforming growth factor-beta and activin A for preantral follicles from adult, immature, and diethylstilbestrol-primed immature mice.
Topics: Activins; Age Factors; Animals; Cells, Cultured; Diethylstilbestrol; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Inhibins; Mice; Ovarian Follicle; Recombinant Proteins; Transforming Growth Factor beta | 1999 |
How the body tells left from right.
Topics: Activins; Animals; Congenital Abnormalities; Embryonic Induction; Heart; Heart Defects, Congenital; Hedgehog Proteins; Humans; Lung; Morphogenesis; Nodal Protein; Oligopeptides; Peptides; Proteins; Situs Inversus; Trans-Activators; Transforming Growth Factor beta; Twins, Conjoined | 1999 |
Hormonal regulation of proliferation of granulosa and Leydig cell lines derived from gonadal tumors of transgenic mice expressing the inhibin-alpha subunit promoter/simian virus 40 T-antigen fusion gene.
Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Artificial Gene Fusion; DNA, Neoplasm; Female; Granulosa Cell Tumor; Inhibins; Leydig Cell Tumor; Male; Mice; Mice, Transgenic; Neoplasms, Hormone-Dependent; Ovarian Neoplasms; Peptides; Promoter Regions, Genetic; RNA, Messenger; Testicular Neoplasms; Thymidine; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Blastoderm; Cloning, Molecular; Digestive System; DNA-Binding Proteins; Embryonic Induction; Endoderm; Fetal Proteins; Fibroblast Growth Factors; Gastrula; GATA5 Transcription Factor; Gene Expression Regulation, Developmental; Germ Cells; Heart; Inhibins; Mesoderm; Molecular Sequence Data; Myocardium; Oligopeptides; Peptides; Polymerase Chain Reaction; Sequence Homology, Amino Acid; Signal Transduction; T-Box Domain Proteins; Tail; Transcription Factors; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins | 1999 |
Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis.
Topics: Activins; Animals; Body Patterning; Embryo, Nonmammalian; Endoderm; Gastrula; Gene Expression Regulation, Developmental; Glycoproteins; Inhibins; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Mesoderm; Mutation; Nodal Signaling Ligands; Proteins; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins; Zebrafish Proteins | 1999 |
Molecular characterization of the follicle defects in the growth differentiation factor 9-deficient ovary.
Topics: Activins; Animals; Aromatase; Bone Morphogenetic Protein 15; Cell Cycle; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cyclooxygenase 2; Estrogen Receptor beta; Female; Follistatin; Glycoproteins; Growth Differentiation Factor 9; Growth Substances; In Situ Nick-End Labeling; Inhibins; Intercellular Signaling Peptides and Proteins; Isoenzymes; Mice; Mice, Inbred Strains; Microfilament Proteins; Muscle Proteins; Ovarian Follicle; Ovary; Peptides; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-kit; Receptors, Estrogen; Receptors, FSH; Receptors, LH; Stem Cell Factor; Theca Cells; Transforming Growth Factor beta | 1999 |
Interruption of activin A autocrine regulation by antisense oligodeoxynucleotides accelerates liver tumor cell proliferation.
Topics: Activins; Autocrine Communication; Cell Division; Humans; Inhibins; Liver Neoplasms; Oligonucleotides, Antisense; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Functional antagonism between activin and osteogenic protein-1 in human embryonal carcinoma cells.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Alkaline Phosphatase; Blotting, Northern; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; DNA-Binding Proteins; Embryonal Carcinoma Stem Cells; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Growth Substances; Humans; Inhibins; Neoplastic Stem Cells; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-jun; Receptors, Growth Factor; RNA, Messenger; Smad6 Protein; Smad7 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Animal-vegetal asymmetries influence the earliest steps in retina fate commitment in Xenopus.
Topics: Activins; Animals; Animals, Genetically Modified; Blastomeres; Bone Morphogenetic Proteins; Carrier Proteins; Cell Lineage; Embryonic Induction; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Glycoproteins; Inhibins; Mesoderm; Models, Biological; Proteins; Proto-Oncogene Proteins; Retina; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 1999 |
Activin A and TGF-beta stimulate phosphorylation of focal adhesion proteins and cytoskeletal reorganization in rat aortic smooth muscle cells.
Topics: Actins; Activins; Angiotensin II; Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Cell Size; Cells, Cultured; Crk-Associated Substrate Protein; Cytoskeletal Proteins; Cytoskeleton; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Inhibins; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase Kinases; Muscle, Smooth, Vascular; Paxillin; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proteins; Rats; Retinoblastoma-Like Protein p130; Signal Transduction; Transforming Growth Factor beta | 1999 |
Co-ordinate expression of activin A and its type I receptor mRNAs during phorbol ester-induced differentiation of human K562 erythroleukemia cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Activin Receptors; Activins; Blotting, Southern; Cell Differentiation; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dimerization; Drug Synergism; Enzyme Activation; Gene Expression; Humans; Inhibins; K562 Cells; Megakaryocytes; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta | 1999 |
Expression of transforming growth factor-beta1, activin A, and their receptors in thyroid follicle cells: negative regulation of thyrocyte growth and function.
Topics: Activin Receptors; Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Division; Cells, Cultured; DNA-Binding Proteins; Inhibins; Ligands; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Reference Values; Signal Transduction; Smad2 Protein; Smad3 Protein; Swine; Thyroid Gland; Trans-Activators; Transforming Growth Factor beta | 1999 |
Developmental biology. Antagonists on the left flank.
Topics: Activins; Animals; Avian Proteins; Chick Embryo; Embryonic and Fetal Development; Embryonic Induction; Hedgehog Proteins; Inhibins; Intercellular Signaling Peptides and Proteins; Left-Right Determination Factors; Mice; Nodal Protein; Proteins; Signal Transduction; Trans-Activators; Transforming Growth Factor beta; Xenopus Proteins | 1999 |
Mode of action of VegT in mesoderm and endoderm formation.
Topics: Activins; Animals; DNA-Binding Proteins; Embryo, Nonmammalian; Embryonic Induction; Endoderm; Fetal Proteins; Gene Expression Regulation, Developmental; Growth Substances; High Mobility Group Proteins; Intercellular Signaling Peptides and Proteins; Mesoderm; Nodal Signaling Ligands; Oligopeptides; Peptides; Proteins; Signal Transduction; SOXF Transcription Factors; T-Box Domain Proteins; Transcription Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins; Zygote | 1999 |
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
Topics: Activins; Amino Acid Sequence; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; COS Cells; Culture Techniques; Embryo, Nonmammalian; Gene Expression; Humans; Inhibins; Ligands; Membrane Proteins; Mice; Molecular Sequence Data; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Sequence Homology; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenopus; Xenopus Proteins | 1999 |
Xenopus Smad4beta is the co-Smad component of developmentally regulated transcription factor complexes responsible for induction of early mesodermal genes.
Topics: Activins; Amino Acid Sequence; Animals; Cell Nucleus; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Inhibins; Mesoderm; Molecular Sequence Data; Nerve Growth Factors; Plasmids; Protein Binding; Sequence Homology, Amino Acid; Signal Transduction; Smad Proteins; Smad2 Protein; Smad4 Protein; Time Factors; Tissue Distribution; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 1999 |
Smad3 inhibits transforming growth factor-beta and activin signaling by competing with Smad4 for FAST-2 binding.
Topics: Activin Receptors; Activins; Base Sequence; Binding Sites; Binding, Competitive; Cells, Cultured; CREB-Binding Protein; DNA-Binding Proteins; Forkhead Transcription Factors; Humans; Inhibins; Molecular Sequence Data; Nerve Growth Factors; Nuclear Proteins; Peptide Fragments; Protein Binding; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Response Elements; Signal Transduction; Smad Proteins; Smad3 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta; Xenopus Proteins | 1999 |
Regulation of Smad7 promoter by direct association with Smad3 and Smad4.
Topics: Activins; Animals; Base Sequence; Cell Line; DNA; DNA-Binding Proteins; Humans; Inhibins; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Receptors, Transforming Growth Factor beta; Smad3 Protein; Smad4 Protein; Smad7 Protein; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells.
Topics: Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Differentiation; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Inhibins; Luciferases; Mammary Glands, Animal; Mesoderm; Mice; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured | 1999 |
Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.
Topics: Activins; Animals; Binding, Competitive; Chimera; DNA-Binding Proteins; Dose-Response Relationship, Drug; Extracellular Matrix; Fibroblasts; Gene Expression Regulation; Glucose-6-Phosphate Isomerase; Homeodomain Proteins; Humans; Inhibins; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Promoter Regions, Genetic; Recombination, Genetic; Regulatory Sequences, Nucleic Acid; Signal Transduction; Smad Proteins; Smad4 Protein; Time Factors; Trans-Activators; Transfection; Transforming Growth Factor beta; Xenopus Proteins | 2000 |
A post-mid-blastula transition requirement for TGFbeta signaling in early endodermal specification.
Topics: Activins; Animals; Blastocyst; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Culture Techniques; Endoderm; Fibroblast Growth Factor 2; Glycoproteins; Inhibins; Nuclear Proteins; Signal Transduction; T-Box Domain Proteins; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2000 |
Activin and bone morphogenetic proteins induce calcitonin gene-related peptide in embryonic sensory neurons in vitro.
Topics: 3T3 Cells; Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Calcitonin Gene-Related Peptide; Cells, Cultured; DNA Primers; Embryo, Mammalian; Ganglia, Spinal; Gene Expression Regulation; Inhibins; Mice; Neurons; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Growth Factor; Transforming Growth Factor beta | 1999 |
Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryo.
Topics: Activins; Animals; Body Patterning; Cell Lineage; Embryonic Induction; Growth Substances; Inhibins; Nodal Protein; Signal Transduction; Transforming Growth Factor beta; Zebrafish | 2000 |
Characterization of a bone morphogenetic protein-responsive Smad-binding element.
Topics: Activins; Animals; Base Sequence; Binding Sites; Bone Morphogenetic Proteins; Cell Line; Consensus Sequence; DNA; DNA-Binding Proteins; Drosophila Proteins; Genes, Reporter; Inhibins; Insect Proteins; Mice; Mutation; Recombinant Fusion Proteins; Repetitive Sequences, Nucleic Acid; Response Elements; Signal Transduction; Smad Proteins; Smad1 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta | 2000 |
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif.
Topics: Activins; Amino Acid Sequence; Animals; Binding Sites; Cycloheximide; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Goosecoid Protein; Homeodomain Proteins; Immediate-Early Proteins; Inhibins; Macromolecular Substances; Mesoderm; Molecular Sequence Data; Morphogenesis; Nerve Growth Factors; Promoter Regions, Genetic; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Repressor Proteins; Smad Proteins; Smad2 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transfection; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2000 |
Synergy of activin and ciliary neurotrophic factor signaling pathways in the induction of vasoactive intestinal peptide gene expression.
Topics: Activins; Animals; Binding Sites; Chickens; Ciliary Neurotrophic Factor; DNA-Binding Proteins; Drug Synergism; Gene Expression Regulation; Humans; Inhibins; Mutation; Neoplasm Proteins; Neuroblastoma; Promoter Regions, Genetic; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Transcription Factor AP-1; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 2000 |
The role of activin and transforming growth factor-beta in the regulation of organ mass in the rat liver.
Topics: Activins; Animals; Apoptosis; DNA; Follistatin; Gene Expression; Glycoproteins; Growth Substances; In Situ Nick-End Labeling; Inhibins; Kinetics; L-Lactate Dehydrogenase; Liver; Male; Organ Size; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta | 2000 |
Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1.
Topics: Activins; Animals; Binding Sites; DNA-Binding Proteins; Enhancer Elements, Genetic; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Inhibins; Introns; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Nodal Protein; Response Elements; Transcription Factors; Transforming Growth Factor beta; Transgenes; Xenopus laevis; Xenopus Proteins | 2000 |
N-Cadherin, a cell adhesion molecule involved in establishment of embryonic left-right asymmetry.
Topics: Activin Receptors, Type II; Activins; Animals; Antibodies, Monoclonal; Body Patterning; Cadherins; Cell Adhesion; Chick Embryo; DNA-Binding Proteins; Embryonic Development; Gastrula; Gene Expression; Gene Expression Regulation, Developmental; Heart; Hedgehog Proteins; Homeobox Protein PITX2; Homeodomain Proteins; In Situ Hybridization; Inhibins; Left-Right Determination Factors; Mesoderm; Morphogenesis; Nodal Protein; Nuclear Proteins; Paired Box Transcription Factors; Proteins; Receptors, Growth Factor; Snail Family Transcription Factors; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 2000 |
Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1beta or interleukin 6 in vitro.
Topics: Activins; Animals; Cell Division; Cell Line; Cells, Cultured; Growth Substances; Humans; Inhibins; Interleukin-1; Interleukin-6; Kinetics; Lymphocyte Activation; Male; Mercaptoethanol; Phytohemagglutinins; Rats; Rats, Inbred Strains; Recombinant Proteins; T-Lymphocytes; Transforming Growth Factor beta | 2000 |
Evidence that members of the TGFbeta superfamily play a role in regulation of the GnRH neuroendocrine axis: expression of a type I serine-threonine kinase receptor for TGRbeta and activin in GnRH neurones and hypothalamic areas of the female rat.
Topics: Activins; Animals; Female; Gonadotropin-Releasing Hormone; Hypothalamus; Inhibins; Multigene Family; Neurons; Neurosecretory Systems; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta | 2000 |
Development of chick axial mesoderm: specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling.
Topics: Activins; Animals; Biomarkers; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cells, Cultured; Chick Embryo; Culture Techniques; Endoderm; Fetal Tissue Transplantation; Glycoproteins; Goosecoid Protein; Homeodomain Proteins; Humans; Immunohistochemistry; In Situ Hybridization; Inhibins; Intercellular Signaling Peptides and Proteins; Mesoderm; Notochord; Quail; Rats; Repressor Proteins; Signal Transduction; Time Factors; Transcription Factors; Transforming Growth Factor beta | 2000 |
Cytokine-specific induction of the TGF-beta inducible early gene (TIEG): regulation by specific members of the TGF-beta family.
Topics: Activins; Blotting, Northern; Bone Morphogenetic Protein 1; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cells, Cultured; DNA-Binding Proteins; Early Growth Response Transcription Factors; Gene Expression Regulation; Humans; Inhibins; Kruppel-Like Transcription Factors; Metalloendopeptidases; Microscopy, Confocal; Osteoblasts; RNA, Messenger; Transcription Factors; Transforming Growth Factor beta; Zinc Fingers | 2000 |
Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor beta1, and activin A: comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells.
Topics: Activins; Animals; Bile Duct Neoplasms; Bile Ducts; Bile Ducts, Intrahepatic; Cell Division; Cholangiocarcinoma; Hepatocyte Growth Factor; Humans; Inhibins; Interleukin-6; Mice; Mice, Inbred BALB C; Proto-Oncogene Proteins c-met; RNA, Messenger; Transforming Growth Factor beta; Tumor Cells, Cultured | 2000 |
Activin to the rescue for overexcited neurons.
Topics: Activins; Animals; Fibroblast Growth Factor 2; Inhibins; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Seizures; Transforming Growth Factor beta | 2000 |
The ontogeny of myostatin, follistatin and activin-B mRNA expression during chicken embryonic development.
Topics: Activins; Animals; Base Sequence; Chick Embryo; DNA Primers; Follistatin; Gene Expression Regulation, Developmental; Glycoproteins; Muscle, Skeletal; Myostatin; Oligopeptides; Peptides; RNA, Messenger; Time Factors; Transforming Growth Factor beta | 1999 |
BMP-2 induces the expression of activin betaA and follistatin in vitro.
Topics: Activins; Animals; Base Sequence; Blotting, Northern; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cycloheximide; Follistatin; Gene Expression Regulation; Glycoproteins; Humans; In Situ Hybridization; Inhibins; Mice; Molecular Sequence Data; Polymerase Chain Reaction; Recombinant Proteins; Sequence Homology, Nucleic Acid; Transforming Growth Factor beta | 2000 |
N-myc down-regulates activin A.
Topics: Activins; Amino Acid Sequence; Cell Line; Clone Cells; Culture Media, Conditioned; Down-Regulation; Gene Amplification; Genes, Reporter; Humans; Inhibins; Kidney; Molecular Sequence Data; Neuroblastoma; Peptides; Promoter Regions, Genetic; Prostatic Secretory Proteins; Proto-Oncogene Proteins c-myc; Retinoblastoma; Sequence Analysis, Protein; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2000 |
BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners.
Topics: Activins; Animals; beta-Galactosidase; Cell Division; Cell Line; COS Cells; DNA-Binding Proteins; Dose-Response Relationship, Drug; Forkhead Transcription Factors; Immunoblotting; Inhibins; Luciferases; Mice; Mice, Inbred C57BL; Mink; Models, Biological; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Trans-Activators; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta | 2000 |
Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-beta family.
Topics: Activins; Animals; Binding Sites; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cloning, Molecular; Dose-Response Relationship, Drug; Follistatin-Related Proteins; HeLa Cells; Humans; Inhibins; Mice; Proteins; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta | 2000 |
Hepatocyte growth factor induces branching tubulogenesis in MDCK cells by modulating the activin-follistatin system.
Topics: Activins; Animals; Cell Differentiation; Cell Division; Cell Line; Collagen; Dose-Response Relationship, Drug; Follistatin; Gels; Gene Expression; Glycoproteins; Hepatocyte Growth Factor; Inhibins; Kidney Tubules; Lac Operon; Recombinant Proteins; RNA, Messenger; Transfection; Transforming Growth Factor beta | 2000 |
Nodal signaling uses activin and transforming growth factor-beta receptor-regulated Smads.
Topics: Activins; Animals; Bone Morphogenetic Proteins; DNA-Binding Proteins; Embryonal Carcinoma Stem Cells; Epidermal Growth Factor; Gene Expression Regulation, Neoplastic; Genes, Reporter; GPI-Linked Proteins; Growth Substances; Homeodomain Proteins; Humans; Inhibins; Intercellular Signaling Peptides and Proteins; Membrane Glycoproteins; Membrane Proteins; Mice; Mutation; Neoplasm Proteins; Neoplastic Stem Cells; Nodal Protein; Phosphorylation; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Trans-Activators; Transcription Factors; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured; Xenopus Proteins | 2001 |
Bottle cell formation in relation to mesodermal patterning in the Xenopus embryo.
Topics: Activins; Animals; Body Patterning; Embryonic Induction; Fetal Proteins; Gene Expression Regulation, Developmental; Glycoproteins; Goosecoid Protein; Homeodomain Proteins; Inhibins; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Mesoderm; Protein Biosynthesis; Proteins; Repressor Proteins; Signal Transduction; T-Box Domain Proteins; Time Factors; Transcription Factors; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins; Zebrafish Proteins | 2000 |
Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction.
Topics: Activins; Amino Acid Sequence; Animals; Cloning, Molecular; Cycloheximide; DNA, Complementary; Embryo, Nonmammalian; Gastrula; Gene Library; Humans; In Situ Hybridization; Inhibins; Left-Right Determination Factors; Mesoderm; Molecular Sequence Data; Nucleic Acid Hybridization; Protein Synthesis Inhibitors; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2000 |
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA.
Topics: Activin Receptors; Activins; Animals; Carrier Proteins; Cell Differentiation; Cell Line; Chimera; DNA-Binding Proteins; Embryo, Mammalian; Endosomal Sorting Complexes Required for Transport; Gene Targeting; Genes, Reporter; Inhibins; Macromolecular Substances; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphoproteins; Phosphorylation; Precipitin Tests; Receptors, Growth Factor; Signal Transduction; Smad2 Protein; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta | 2000 |
Regulation and actions of Smad7 in the modulation of activin, inhibin, and transforming growth factor-beta signaling in anterior pituitary cells.
Topics: Activins; Animals; Cells, Cultured; DNA-Binding Proteins; Follistatin; Glycoproteins; Inhibins; Male; Mice; Osmolar Concentration; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Smad7 Protein; Time Factors; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Crosses, Genetic; Ectodysplasins; Epidermal Growth Factor; Epithelial Cells; Female; Fibroblast Growth Factor 4; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Inhibins; Male; Membrane Proteins; Mice; Mice, Inbred Strains; Mitogens; Molar; Odontogenesis; Organ Culture Techniques; Proto-Oncogene Proteins; Receptors, Tumor Necrosis Factor; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins; Zebrafish Proteins | 2001 |
Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP).
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Animals; Cells, Cultured; Inhibins; Prostatic Secretory Proteins; Receptors, Growth Factor; Receptors, Peptide; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta | 2001 |
Activin A and activin receptors in thyroid cancer.
Topics: Activin Receptors; Activins; Adenocarcinoma, Follicular; Aged; Alternative Splicing; Apoptosis; Carcinoma, Papillary; Cell Division; Child; Culture Media; Epithelial Cells; Female; Gene Expression; Humans; Inhibins; Lymphatic Metastasis; Male; Middle Aged; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thyroid Neoplasms; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
Expression of FLRG, a novel activin A ligand, is regulated by TGF-beta and during hematopoiesis [corrected].
Topics: Activins; Animals; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Chlorocebus aethiops; COS Cells; Follistatin; Follistatin-Related Proteins; Gene Expression Regulation, Developmental; Glycoproteins; Hematopoiesis; Hematopoietic Stem Cells; Humans; Inhibins; Ligands; Megakaryocytes; Myeloid Cells; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Transfection; Transforming Growth Factor beta; U937 Cells | 2001 |
Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone.
Topics: Activins; Animals; Carrier Proteins; Cell Line; COS Cells; Cytoplasm; DNA-Binding Proteins; Epitopes; Gene Deletion; Genes, Reporter; Green Fluorescent Proteins; Humans; Immunoblotting; Inhibins; Intracellular Signaling Peptides and Proteins; Ligands; Luminescent Proteins; Mice; Microscopy, Fluorescence; Models, Biological; Molecular Chaperones; Plasmids; Precipitin Tests; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Signal Transduction; Smad2 Protein; Smad4 Protein; Trans-Activators; Transcription, Genetic; Transfection; Transforming Growth Factor beta | 2001 |
The propeptide of the transforming growth factor-beta superfamily member, macrophage inhibitory cytokine-1 (MIC-1), is a multifunctional domain that can facilitate protein folding and secretion.
Topics: Activins; Amino Acid Sequence; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; CHO Cells; Cricetinae; Cytokines; DNA Primers; Glycosylation; Growth Differentiation Factor 15; Humans; Inhibins; Mice; Models, Molecular; Molecular Sequence Data; Polymerase Chain Reaction; Protein Folding; Protein Precursors; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Fusion Proteins; Transfection; Transforming Growth Factor beta | 2001 |
The p38 MAPK pathway is required for cell growth inhibition of human breast cancer cells in response to activin.
Topics: Activins; Breast Neoplasms; Cell Division; Female; Humans; Inhibins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Transforming Growth Factor beta; Tumor Cells, Cultured | 2001 |
The regulation of apoptosis by activin and transforming growth factor-beta in early neoplastic and tumorigenic ovarian surface epithelium.
Topics: Activin Receptors; Activins; Apoptosis; bcl-2-Associated X Protein; Cell Line; Female; Humans; Inhibins; Ovarian Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Growth Factor; RNA, Messenger; Transforming Growth Factor beta | 2001 |
FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse.
Topics: Activins; Animals; Body Patterning; DNA-Binding Proteins; Forkhead Transcription Factors; Gastrula; Gene Expression Regulation, Developmental; In Situ Hybridization; Inhibins; Mice; Mice, Inbred ICR; Mice, Knockout; Mutagenesis; Nodal Protein; Polymerase Chain Reaction; Sequence Deletion; Signal Transduction; Smad2 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 2001 |
Developmental biology. Fishing for morphogens.
Topics: Activins; Animals; Body Patterning; Drosophila; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Inhibins; Intracellular Signaling Peptides and Proteins; Morphogenesis; Nodal Signaling Ligands; Signal Transduction; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins | 2001 |
Activation of the TGF-beta/activin-Smad2 pathway during allergic airway inflammation.
Topics: Activins; Animals; Base Sequence; Blotting, Western; Bronchitis; DNA Primers; DNA-Binding Proteins; Female; Hypersensitivity; Immunohistochemistry; Inhibins; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta | 2001 |
The role of an endogenous PKA inhibitor, PKIalpha, in organizing left-right axis formation.
Topics: Activins; Animals; Body Patterning; Carrier Proteins; Chick Embryo; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Hedgehog Proteins; Homeobox Protein PITX2; Homeodomain Proteins; Inhibins; Nodal Protein; Nuclear Proteins; Oligonucleotides, Antisense; Proteins; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 2001 |
FLRG, an activin-binding protein, is a new target of TGFbeta transcription activation through Smad proteins.
Topics: Activins; Base Sequence; Cloning, Molecular; Consensus Sequence; DNA-Binding Proteins; Follistatin-Related Proteins; Genes, Reporter; Glycoproteins; Humans; Inhibins; Molecular Sequence Data; Promoter Regions, Genetic; Response Elements; RNA, Messenger; Smad3 Protein; Smad4 Protein; Trans-Activators; Transcriptional Activation; Transforming Growth Factor beta; Tumor Cells, Cultured; Up-Regulation | 2001 |
Effect of cytokines and growth factors on the secretion of inhibin A, activin A and follistatin by term placental villous trophoblasts in culture.
Topics: Activins; Cells, Cultured; Chorionic Villi; Cytokines; Female; Follistatin; Granulocyte-Macrophage Colony-Stimulating Factor; Growth Substances; Humans; Inhibin-beta Subunits; Inhibins; Interleukin-1; Placenta; Pregnancy; Transforming Growth Factor beta; Trophoblasts; Tumor Necrosis Factor-alpha | 2001 |
Murine Schnurri-2 is required for positive selection of thymocytes.
Topics: Activins; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Bone Morphogenetic Proteins; Carrier Proteins; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Clonal Deletion; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epithelial Cells; Female; Gene Expression Regulation, Developmental; Gene Targeting; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Radiation Chimera; Self Tolerance; Signal Transduction; Smad4 Protein; Species Specificity; Spleen; Stromal Cells; T-Lymphocyte Subsets; Thymus Gland; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 2001 |
Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy.
Topics: Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cells, Cultured; Cytokines; Diabetic Nephropathies; Disease Progression; Down-Regulation; Follistatin; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Mice; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Recombinant Proteins; Reference Values; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2001 |
Transforming growth factor beta and activin tonically inhibit DNA synthesis in the rat liver.
Topics: Activin Receptors; Activins; Animals; Apoptosis; Bromodeoxyuridine; Cell Nucleus; DNA; Gene Transfer Techniques; Genes, Dominant; Immunohistochemistry; Inhibin-beta Subunits; Liver; Male; Organ Size; Protein Isoforms; Rats; Rats, Wistar; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2001 |
Molecular and cellular analysis of embryonic avian tongue development.
Topics: Activins; Animals; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Carrier Proteins; Cell Division; Chick Embryo; Epithelium; Fetal Proteins; Follistatin; Gene Expression; Hedgehog Proteins; Membrane Proteins; Mesoderm; Patched Receptors; Proteins; Receptor Protein-Tyrosine Kinases; Receptor, EphA4; Receptors, Cell Surface; RNA, Messenger; Tongue; Trans-Activators; Transforming Growth Factor beta | 2001 |
Mechanisms of left-right asymmetry: what's right and what's left?
Topics: Activins; Animals; Biological Evolution; Chick Embryo; Dominance, Cerebral; Functional Laterality; Humans; Mice; Models, Biological; Proteins; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Zebrafish | 2001 |
Cloning, characterization, and tissue expression pattern of mouse Nma/BAMBI during odontogenesis.
Topics: Activins; Amino Acids; Animals; Base Pairing; Blotting, Northern; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line; Cloning, Molecular; Conserved Sequence; DNA, Complementary; Gene Expression Regulation; Genes, vif; Genetic Vectors; Humans; In Situ Hybridization; Membrane Proteins; Mice; Molecular Sequence Data; Odontogenesis; Plasmids; Rabbits; Reading Frames; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2001 |
The Mad1 transcription factor is a novel target of activin and TGF-beta action in keratinocytes: possible role of Mad1 in wound repair and psoriasis.
Topics: Activins; Adult; Aged; Animals; Blotting, Western; Cell Cycle Proteins; Cell Differentiation; Cell Division; Cell Line; Cell Nucleus; COS Cells; DNA; DNA, Complementary; Epidermal Cells; Epidermis; Humans; In Situ Hybridization; Keratinocytes; Mice; Mice, Inbred BALB C; Middle Aged; Neutrophils; Nuclear Proteins; Phosphoproteins; Psoriasis; Repressor Proteins; RNA, Messenger; Skin; Time Factors; Transcription Factors; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured; Wound Healing | 2001 |
Cerebrospinal fluid contains biologically active bone morphogenetic protein-7.
Topics: Activins; Animals; Biological Assay; Blotting, Western; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cattle; Cells, Cultured; Cerebrospinal Fluid; Dendrites; Dose-Response Relationship, Drug; Follistatin; Neurons; Radioimmunoassay; Sympathetic Nervous System; Transforming Growth Factor beta | 2001 |
Role of TGF-beta family in osteoclastogenesis induced by RANKL.
Topics: Acid Phosphatase; Activins; Animals; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cell Differentiation; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Inhibin-beta Subunits; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Kinetics; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Osteoclasts; Proto-Oncogene Proteins pp60(c-src); RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Tartrate-Resistant Acid Phosphatase; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures.
Topics: Activins; Animals; Bone Density; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cell Division; Cells, Cultured; Cellular Senescence; Follistatin; Inhibin-beta Subunits; Inhibins; Male; Mice; Osteoblasts; Osteoclasts; Proteins; Stem Cells; Transforming Growth Factor beta | 2002 |
Differential effect of activin A and BMP-7 on myofibroblast differentiation and the role of the Smad signaling pathway.
Topics: Activins; Blotting, Northern; Blotting, Western; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Cornea; DNA Primers; DNA-Binding Proteins; Down-Regulation; Extracellular Matrix Proteins; Fibroblasts; Follistatin; Humans; Inhibin-beta Subunits; Microfilament Proteins; Phosphorylation; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Trans-Activators; Transfection; Transforming Growth Factor beta | 2002 |
Regulation of nodal signalling and mesendoderm formation by TARAM-A, a TGFbeta-related type I receptor.
Topics: Activins; Animals; Biomarkers; Body Patterning; Bone Morphogenetic Proteins; Embryo, Nonmammalian; Endoderm; Gene Expression Regulation, Developmental; Genes, Dominant; Homeodomain Proteins; Intracellular Signaling Peptides and Proteins; Mesoderm; Mutagenesis; Nodal Protein; Nodal Signaling Ligands; Phenotype; Protein Serine-Threonine Kinases; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins | 2002 |
Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis.
Topics: Activins; Apoptosis; Carcinoma, Hepatocellular; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Follistatin; Humans; Liver Cirrhosis, Alcoholic; Liver Neoplasms; Male; Middle Aged; Transforming Growth Factor beta | 2002 |
Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Chick Embryo; DNA-Binding Proteins; Embryo, Nonmammalian; Extremities; Follistatin; Gene Expression Regulation, Developmental; Morphogenesis; Muscle, Skeletal; Paired Box Transcription Factors; PAX3 Transcription Factor; Signal Transduction; Transcription Factors; Transforming Growth Factor beta | 2002 |
Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 5; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Cadherins; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Embryonic and Fetal Development; Epithelial Cells; Gene Expression Regulation, Developmental; Glucagon; Inhibin-beta Subunits; Insulin; Laminin; Mice; Mice, Inbred CBA; Pancreas; Transforming Growth Factor beta | 2002 |
Transforming growth factor-beta1 inhibits steroidogenesis in human trophoblast cells.
Topics: Activins; Aromatase; Cell Line; Estradiol; Female; Follistatin; Humans; Progesterone; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Trophoblasts | 2002 |
Multiple interactions between maternally-activated signalling pathways control Xenopus nodal-related genes.
Topics: Activins; Animals; beta Catenin; Cell Lineage; Cytoskeletal Proteins; Endoderm; Female; Gene Expression Regulation, Developmental; Genes, Dominant; Genes, Reporter; Intracellular Signaling Peptides and Proteins; Luciferases; Mesoderm; Mothers; Nodal Signaling Ligands; Oligonucleotides, Antisense; Plasmids; Promoter Regions, Genetic; Protein Biosynthesis; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; T-Box Domain Proteins; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 2002 |
Stage-specific expression of Smad2 and Smad3 during folliculogenesis.
Topics: Activins; Animals; Cells, Cultured; Chorionic Gonadotropin; Corpus Luteum; Estrous Cycle; Female; Follicle Stimulating Hormone; Gene Expression; Gonadotropins, Equine; Granulosa Cells; Humans; Immunohistochemistry; Inhibin-beta Subunits; Oocytes; Ovarian Follicle; Ovary; Rats; Rats, Sprague-Dawley; Theca Cells; Transforming Growth Factor beta | 2002 |
Induction of cachexia in mice by systemically administered myostatin.
Topics: 3T3 Cells; Activins; Adipose Tissue; Animals; Body Weight; Cachexia; CHO Cells; Cricetinae; Eating; Female; Follistatin; Liver; Mice; Mice, Nude; Muscle Fibers, Skeletal; Muscle, Skeletal; Myostatin; Organ Size; Peptide Fragments; Recombinant Proteins; Transforming Growth Factor beta; Wasting Syndrome; Weight Loss | 2002 |
SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.
Topics: 3T3 Cells; Activating Transcription Factor 2; Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Osmotic Pressure; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proteins; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta | 2002 |
Activin and bone morphogenetic proteins are present in perinatal sensory neuron target tissues that induce neuropeptides.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Ganglia, Spinal; Muscles; Neurons, Afferent; Neuropeptides; Rats; Skin; Transforming Growth Factor beta | 2002 |
The latent-TGFbeta-binding-protein-1 (LTBP-1) is expressed in the organizer and regulates nodal and activin signaling.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; CHO Cells; Cloning, Molecular; Cricetinae; DNA, Complementary; Humans; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Latent TGF-beta Binding Proteins; Mesoderm; Molecular Sequence Data; Nucleolus Organizer Region; Protein Structure, Tertiary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Signal Transduction; Time Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2002 |
A component of the ARC/Mediator complex required for TGF beta/Nodal signalling.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Humans; Macromolecular Substances; Mesoderm; Nerve Growth Factors; Nodal Protein; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Signal Transduction; Smad Proteins; Smad2 Protein; Smad3 Protein; Smad4 Protein; Trans-Activators; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2002 |
FSH and TGF-beta superfamily members regulate granulosa cell connective tissue growth factor gene expression in vitro and in vivo.
Topics: Activins; Animals; Blotting, Northern; Bone Morphogenetic Protein 15; Cell Differentiation; Cells, Cultured; Connective Tissue Growth Factor; Cyclic AMP; Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Gene Expression Regulation; Granulosa Cells; Growth Differentiation Factor 9; Growth Substances; Immediate-Early Proteins; In Situ Hybridization; Inhibin-beta Subunits; Intercellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Functional relevance of activin A in the intestinal epithelium.
Topics: Activin Receptors; Activins; Animals; Apoptosis; Cell Division; Cell Line; Cell Movement; Colon; Flow Cytometry; HT29 Cells; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Inhibin-beta Subunits; Intestinal Mucosa; Polymerase Chain Reaction; Rats; RNA, Messenger; Transforming Growth Factor beta; Wound Healing | 2002 |
Zygotic Wnt activity is required for Brachyury expression in the early Xenopus laevis embryo.
Topics: Activins; Animals; Cadherins; Gene Expression; Glycoproteins; HMGB Proteins; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Ligands; Promoter Regions, Genetic; Proteins; Proto-Oncogene Proteins; Signal Transduction; T-Box Domain Proteins; TCF Transcription Factors; Transcription Factor 7-Like 1 Protein; Transcription Factors; Transforming Growth Factor beta; Wnt Proteins; Xenopus laevis; Xenopus Proteins; Zebrafish Proteins; Zygote | 2002 |
The nodal target gene Xmenf is a component of an FGF-independent pathway of ventral mesoderm induction in Xenopus.
Topics: Activins; Amino Acid Sequence; Animals; beta-Galactosidase; Blotting, Northern; Body Patterning; Cell Lineage; Cell Nucleus; Cloning, Molecular; DNA-Binding Proteins; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Gene Library; Green Fluorescent Proteins; Immunohistochemistry; In Situ Hybridization; Luminescent Proteins; MAP Kinase Signaling System; Mesoderm; Models, Biological; Molecular Sequence Data; Nodal Signaling Ligands; Nuclear Proteins; Plasmids; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proteins; Recombinant Fusion Proteins; RNA; RNA, Messenger; Signal Transduction; Smad2 Protein; Time Factors; Tissue Distribution; Trans-Activators; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2002 |
Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells.
Topics: Activins; Adult; Bone Morphogenetic Proteins; DNA-Binding Proteins; Female; Gene Expression Regulation; Granulosa Cells; Humans; Inhibins; Signal Transduction; Smad Proteins; Smad1 Protein; Smad2 Protein; Trans-Activators; Transduction, Genetic; Transforming Growth Factor beta | 2002 |
Direct and indirect regulation of derrière, a Xenopus mesoderm-inducing factor, by VegT.
Topics: Activins; Animals; Animals, Genetically Modified; Base Sequence; Binding Sites; DNA-Binding Proteins; Embryo, Nonmammalian; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Homeostasis; Intercellular Signaling Peptides and Proteins; Mesoderm; Molecular Sequence Data; Nodal Signaling Ligands; Promoter Regions, Genetic; Proteins; T-Box Domain Proteins; Transcription Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2002 |
Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells.
Topics: Activins; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Endothelium, Vascular; Fibroblast Growth Factor 1; Humans; Inhibin-beta Subunits; Muscle, Smooth, Vascular; Smad7 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1; Umbilical Veins; Vasoconstriction | 2003 |
A novel function of bone morphogenetic protein-15 in the pituitary: selective synthesis and secretion of FSH by gonadotropes.
Topics: Activins; Animals; Bone Morphogenetic Protein 15; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line; Cells, Cultured; Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Gene Expression; Gene Expression Regulation; Growth Differentiation Factor 9; Inhibin-beta Subunits; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Luteinizing Hormone, beta Subunit; Male; Mice; Ovary; Pituitary Gland; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Receptors, FSH; Receptors, LHRH; RNA, Messenger; Transcription, Genetic; Transforming Growth Factor beta | 2002 |
Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.
Topics: Activins; Animals; Apoptosis; Hematopoiesis; Humans; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Signal Transduction; Transcription Factors; Transforming Growth Factor beta | 2002 |
Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron.
Topics: Activins; Animals; Base Sequence; Binding Sites; Conserved Sequence; DNA-Binding Proteins; Evolution, Molecular; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Genes, Reporter; Homeodomain Proteins; Introns; LIM-Homeodomain Proteins; Models, Biological; Models, Genetic; Molecular Sequence Data; Nerve Growth Factors; Nodal Protein; Protein Binding; RNA, Messenger; Sequence Homology, Nucleic Acid; Signal Transduction; Smad Proteins; Smad4 Protein; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins; Zebrafish; Zebrafish Proteins | 2002 |
Transforming growth factor-beta modulates inhibin A bioactivity in the LbetaT2 gonadotrope cell line by competing for binding to betaglycan.
Topics: Activins; Animals; beta-Galactosidase; Binding, Competitive; Cell Line; Follicle Stimulating Hormone, beta Subunit; Humans; Inhibin-beta Subunits; Inhibins; Iodine Radioisotopes; Luciferases; Mice; Pituitary Gland; Promoter Regions, Genetic; Proteoglycans; Receptors, LHRH; Receptors, Transforming Growth Factor beta; Recombinant Fusion Proteins; Response Elements; Reverse Transcriptase Polymerase Chain Reaction; Sheep; Transcription, Genetic; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2 | 2002 |
Microarray analysis of bone morphogenetic protein, transforming growth factor beta, and activin early response genes during osteoblastic cell differentiation.
Topics: Activins; Animals; Base Sequence; Blotting, Northern; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; DNA Primers; Expressed Sequence Tags; Gene Expression Regulation; Inhibin-beta Subunits; Mice; Oligonucleotide Array Sequence Analysis; Osteoblasts; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcriptional Activation; Transforming Growth Factor beta | 2002 |
Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation.
Topics: Activins; Animals; Embryo, Nonmammalian; Gastrula; Gene Expression Regulation, Developmental; Goosecoid Protein; Homeodomain Proteins; Intercellular Signaling Peptides and Proteins; Left-Right Determination Factors; Mesoderm; Nodal Protein; Nodal Signaling Ligands; Oligonucleotides, Antisense; Organizers, Embryonic; Proteins; Proto-Oncogene Proteins; Repressor Proteins; Signal Transduction; T-Box Domain Proteins; Transcription Factors; Transforming Growth Factor beta; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 2002 |
Identification of activin A and follistatin in human milk.
Topics: Activins; Adult; Dimerization; Enzyme-Linked Immunosorbent Assay; Female; Follistatin; Humans; Inhibin-beta Subunits; Milk, Human; Pregnancy; Time Factors; Transforming Growth Factor beta | 2002 |
Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family.
Topics: Activins; Antigens, CD34; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Erythropoiesis; Follistatin; Follistatin-Related Proteins; Gene Expression; Gene Expression Profiling; Humans; Inhibin-beta Subunits; Recombinant Proteins; Transforming Growth Factor beta | 2003 |
Activin A and follistatin in acute liver failure.
Topics: Acetaminophen; Activins; Adolescent; Adult; Analgesics, Non-Narcotic; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Follistatin; Hepatitis; Humans; Inhibin-beta Subunits; Liver Failure, Acute; Male; Middle Aged; Thymidine; Transforming Growth Factor beta; Tumor Cells, Cultured | 2003 |
Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Bone Morphogenetic Proteins; Ectoderm; Embryo, Nonmammalian; Molecular Sequence Data; Nodal Protein; Proto-Oncogene Proteins; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins; Xenopus; Xenopus Proteins; Zebrafish Proteins | 2003 |
Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Embryo, Nonmammalian; Embryonic Induction; Gastrula; Gene Deletion; Gene Expression Regulation, Developmental; Membrane Proteins; Mesoderm; Nodal Protein; Recombinant Fusion Proteins; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2003 |
Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells.
Topics: Activins; Animals; Bromodeoxyuridine; Cell Differentiation; Cell Division; Coculture Techniques; Epithelial Cells; Epithelium; Gene Expression Regulation; Hedgehog Proteins; Immunohistochemistry; In Situ Hybridization; Inhibin-beta Subunits; Male; Membrane Proteins; Mice; Patched Receptors; Patched-1 Receptor; Prostate; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Trans-Activators; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2003 |
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions.
Topics: Activin Receptors, Type II; Activins; Binding Sites; Crystallography, X-Ray; Inhibin-beta Subunits; Ligands; Models, Molecular; Protein Conformation; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2003 |
Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads.
Topics: Activins; Alternative Splicing; Animals; Cell Division; Cell Line; Cloning, Molecular; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Developmental; Hematopoietic Stem Cells; Humans; Mice; Promoter Regions, Genetic; Protein Binding; Response Elements; RNA, Messenger; Signal Transduction; Smad Proteins; Trans-Activators; Transcription, Genetic; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Xenopus | 2003 |
Activin and transforming growth factor-beta as local regulators of ovarian steroidogenesis in the goldfish.
Topics: Activins; Animals; Base Sequence; Female; Goldfish; Humans; Molecular Sequence Data; Ovary; Oviducts; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sexual Maturation; Steroids; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vitellogenesis | 2003 |
The Booroola mutation in sheep is associated with an alteration of the bone morphogenetic protein receptor-IB functionality.
Topics: Activins; Analysis of Variance; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cell Division; Cell Line; Cells, Cultured; Female; Genotype; Granulosa Cells; Growth Differentiation Factor 5; Humans; Inhibin-beta Subunits; Progesterone; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Sheep; Signal Transduction; Transfection; Transforming Growth Factor beta | 2003 |
Role of activin A in murine mast cells: modulation of cell growth, differentiation, and migration.
Topics: Activins; Animals; Cell Differentiation; Cell Division; Cell Movement; Cells, Cultured; Chymases; Dose-Response Relationship, Drug; Inhibin-beta Subunits; Mast Cells; Mice; Mice, Inbred BALB C; RNA, Messenger; Serine Endopeptidases; Signal Transduction; Transcription, Genetic; Transforming Growth Factor beta | 2003 |
Mechanisms of action of transforming growth factor beta on the expression of follicle-stimulating hormone receptor messenger ribonucleic acid levels in rat granulosa cells.
Topics: 5' Flanking Region; Activins; Animals; Cells, Cultured; Dactinomycin; Dose-Response Relationship, Drug; Female; Follicle Stimulating Hormone; Follistatin; Granulosa Cells; Rats; Rats, Wistar; Receptors, FSH; RNA Stability; RNA, Messenger; Time Factors; Transcription, Genetic; Transforming Growth Factor beta | 2003 |
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo.
Topics: Activin Receptors, Type I; Activins; Animals; Antibodies, Monoclonal; Breast Neoplasms; Cell Division; Cell Separation; Cell Transformation, Neoplastic; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Epidermal Growth Factor; Epitopes; Flow Cytometry; GPI-Linked Proteins; Humans; Immunoblotting; Immunoglobulin G; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Ligands; Male; Membrane Glycoproteins; Mice; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Nodal Protein; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2003 |
A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure.
Topics: Actins; Activins; Animals; Base Sequence; Biological Evolution; Cell Movement; DNA; Drosophila; Enzyme Activation; Epithelium; Eyelids; JNK Mitogen-Activated Protein Kinases; Keratinocytes; MAP Kinase Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Signal Transduction; Transforming Growth Factor beta | 2003 |
TLP, a novel modulator of TGF-beta signaling, has opposite effects on Smad2- and Smad3-dependent signaling.
Topics: Activins; Amino Acid Sequence; Animals; Autophagy-Related Proteins; Carrier Proteins; Cell Line; Cloning, Molecular; COS Cells; DNA-Binding Proteins; DNA, Complementary; Endocytosis; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Membrane Proteins; Models, Biological; Molecular Sequence Data; Phosphorylation; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad4 Protein; Trans-Activators; Transcription Factors; Transfection; Transforming Growth Factor beta; Vesicular Transport Proteins | 2003 |
Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis.
Topics: Actins; Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Autocrine Communication; Blotting, Western; Cells, Cultured; Collagen; Dose-Response Relationship, Drug; Fibrosis; Follistatin; Inhibin-beta Subunits; Microscopy, Fluorescence; Pancreas; Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2003 |
Activin/Nodal signals mediate the ventral expression of myf-5 in Xenopus gastrula embryos.
Topics: Activins; Animals; Base Sequence; DNA Primers; DNA-Binding Proteins; Female; Gastrula; Gene Expression Regulation, Developmental; Muscle Proteins; Myogenic Regulatory Factor 5; Nodal Protein; Promoter Regions, Genetic; Trans-Activators; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2003 |
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.
Topics: Activins; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Imidazoles; Inhibin-beta Subunits; Mitogen-Activated Protein Kinases; Mutation; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Smad Proteins; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Transcriptional activation of mouse mast cell Protease-7 by activin and transforming growth factor-beta is inhibited by microphthalmia-associated transcription factor.
Topics: Activins; Animals; Cell Movement; COS Cells; DNA-Binding Proteins; DNA, Complementary; Genes, Reporter; Humans; Immunoblotting; Luciferases; Mast Cells; Mice; Mice, Inbred BALB C; Microphthalmia-Associated Transcription Factor; NIH 3T3 Cells; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Serine Endopeptidases; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Tryptases; Up-Regulation | 2003 |
The role of follistatin domains in follistatin biological action.
Topics: Activins; Amino Acid Sequence; Binding Sites; Cell Division; Follistatin; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Conformation; Recombinant Proteins; Transforming Growth Factor beta | 2004 |
Evaluation of members of the TGFbeta superfamily as candidates for the oocyte factors that control mouse cumulus expansion and steroidogenesis.
Topics: Activins; Animals; Antibodies, Monoclonal; Bone Morphogenetic Protein 15; Coculture Techniques; Female; Follicle Stimulating Hormone; Granulosa Cells; Growth Differentiation Factor 9; Inhibin-beta Subunits; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Oocytes; Progesterone; Transforming Growth Factor beta; Zona Pellucida | 2003 |
Regulation mechanisms of retinal pigment epithelial cell migration by the TGF-beta superfamily.
Topics: Activin Receptors, Type I; Activins; Cell Division; Cell Line; Cell Movement; Cell Nucleus; Cytoplasm; DNA-Binding Proteins; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Inhibin-beta Subunits; Pigment Epithelium of Eye; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad Proteins; Smad1 Protein; Smad2 Protein; Smad3 Protein; Smad4 Protein; Trans-Activators; Transforming Growth Factor beta; Wound Healing | 2003 |
Transforming growth factor-beta- and Activin-Smad signaling pathways are activated at distinct maturation stages of the thymopoeisis.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Blotting, Western; CD4 Antigens; CD8 Antigens; Cell Differentiation; DNA-Binding Proteins; Female; Flow Cytometry; Gene Expression; Hyaluronan Receptors; Immunohistochemistry; Inhibin-beta Subunits; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Interleukin-2; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad4 Protein; T-Lymphocyte Subsets; T-Lymphocytes; Thymus Gland; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Follicle-restricted compartmentalization of transforming growth factor beta superfamily ligands in the feline ovary.
Topics: Activins; Animals; Cats; Cell Compartmentation; Cloning, Molecular; Cytoplasm; DNA-Binding Proteins; Female; Granulosa Cells; Inhibin-beta Subunits; Ligands; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta | 2004 |
TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.
Topics: Activins; Animals; Benzamides; Blood Vessels; Capillary Permeability; Cell Differentiation; Cell Division; Cells, Cultured; Claudin-5; Dioxoles; Endothelium, Vascular; Fetus; Membrane Proteins; Mice; Neovascularization, Physiologic; Pluripotent Stem Cells; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Stem Cells; Tight Junctions; Transforming Growth Factor beta; Up-Regulation | 2003 |
Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein 15; Bone Morphogenetic Proteins; Cells, Cultured; COS Cells; DNA-Binding Proteins; Female; Granulosa Cells; Growth Differentiation Factor 9; Intercellular Signaling Peptides and Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Smad Proteins; Smad2 Protein; Smad3 Protein; Smad6 Protein; Smad7 Protein; Trans-Activators; Transforming Growth Factor beta | 2004 |
Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cloning, Molecular; Databases as Topic; DNA, Complementary; Female; Follistatin-Related Proteins; Gene Library; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Inhibin-beta Subunits; Male; Molecular Sequence Data; PC12 Cells; Polymerase Chain Reaction; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Time Factors; Tissue Distribution; Transfection; Transforming Growth Factor beta | 2003 |
Transforming growth factor (TGF)beta, fibroblast growth factor (FGF) and retinoid signalling pathways promote pancreatic exocrine gene expression in mouse embryonic stem cells.
Topics: Activins; Amylases; Animals; Biomarkers; Cell Differentiation; Cell Lineage; Culture Media, Conditioned; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Homeodomain Proteins; Inhibin-beta Subunits; Kinetics; Mice; Pancreas; Phenotype; Retinoids; RNA, Messenger; Signal Transduction; Stem Cells; Time Factors; Trans-Activators; Transcription Factors; Transforming Growth Factor beta; Tretinoin; Veratrum Alkaloids | 2004 |
Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells.
Topics: Activin Receptors; Activins; Analysis of Variance; Astrocytoma; Blotting, Northern; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Bromodeoxyuridine; Cell Division; Cell Line, Tumor; Culture Media, Conditioned; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Hepatocyte Growth Factor; Humans; Inhibin-beta Subunits; Ligands; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smad Proteins; Starvation; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.
Topics: Activin Receptors, Type I; Activins; Animals; Benzamides; Cell Death; COS Cells; Dioxoles; DNA-Binding Proteins; Drug Interactions; Genes, Reporter; Humans; Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Proteins; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad Proteins; Trans-Activators; Transforming Growth Factor beta; Tumor Cells, Cultured | 2004 |
The dependence of transforming growth factor-beta-induced collagen production on autocrine factor activin A in hepatic stellate cells.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Cells, Cultured; Collagen; Follistatin; Genes, Dominant; Hepatocytes; Humans; Inhibin-beta Subunits; Proteins; Rats; Recombinant Proteins; Transforming Growth Factor beta | 2004 |
[The expression of activin A and transforming growth factor-beta 1 during rabbit mandibual distraction osteogenesis].
Topics: Activins; Animals; Female; Immunohistochemistry; Inhibin-beta Subunits; Mandible; Osteogenesis, Distraction; Rabbits; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2003 |
Activin A inhibits growth-inhibitory signals by TGF-beta1 in differentiated human endometrial adenocarcinoma cells.
Topics: Activins; Adenocarcinoma; Cell Differentiation; Cell Division; Cell Line, Tumor; Endometrial Neoplasms; Female; Flow Cytometry; Humans; Inhibin-beta Subunits; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Shh-dependent differentiation of intestinal tissue from embryonic pancreas by activin A.
Topics: Activins; Animals; Carrier Proteins; Cell Differentiation; Fatty Acid-Binding Proteins; Hedgehog Proteins; Inhibin-beta Subunits; Intestinal Mucosa; Intestines; Mice; Microscopy, Fluorescence; Pancreas; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Time Factors; Trans-Activators; Transforming Growth Factor beta; Veratrum Alkaloids | 2004 |
Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin.
Topics: Activins; Animals; Binding, Competitive; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Cattle; Cells, Cultured; DNA-Binding Proteins; Female; Follistatin; Granulosa Cells; Immunohistochemistry; Inhibin-beta Subunits; Ovarian Follicle; Phosphorylation; Protein Binding; Receptors, Growth Factor; Smad Proteins; Smad2 Protein; Trans-Activators; Transforming Growth Factor beta | 2004 |
hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation.
Topics: Activins; Alternative Splicing; Amino Acid Sequence; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Carrier Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Chlorocebus aethiops; Conserved Sequence; COS Cells; Cysteine; Evolution, Molecular; Extracellular Matrix Proteins; Female; Gene Expression Profiling; Humans; Inhibin-beta Subunits; Insulin; Male; Mice; Molecular Sequence Data; Myoblasts; Osteoblasts; Protein Binding; Protein Isoforms; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Homology, Amino Acid; Transforming Growth Factor beta | 2004 |
An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors.
Topics: Activin Receptors, Type II; Activins; Amino Acid Sequence; Binding, Competitive; Cell Line; Cross-Linking Reagents; Culture Media, Conditioned; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Follicle Stimulating Hormone; Humans; Ligands; Molecular Sequence Data; Mutagenesis; Mutation; Myostatin; Protein Binding; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Transfection; Transforming Growth Factor beta | 2004 |
Ectopic activation of Dpp signalling in the male Drosophila germline inhibits germ cell differentiation.
Topics: Activins; Animals; Cell Differentiation; Cell Proliferation; Drosophila melanogaster; Drosophila Proteins; Germ Cells; Male; Signal Transduction; Spermatogonia; Stem Cells; Testis; Transforming Growth Factor beta | 2004 |
Activin and follistatin in rat mammary gland.
Topics: Activin Receptors; Activins; Animals; Caseins; Cell Differentiation; Cell Proliferation; Female; Follistatin; Gene Expression Regulation; Inhibin-beta Subunits; Inhibins; Lactation; Mammary Glands, Animal; Pregnancy; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor beta | 2004 |
Follistatin restricts bone morphogenetic protein (BMP)-2 action on the differentiation of osteoblasts in fetal rat mandibular cells.
Topics: Activins; Alkaline Phosphatase; Animals; Antibodies, Monoclonal; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Fetus; Follistatin; Humans; Inhibin-beta Subunits; Mandible; Osteoblasts; Osteogenesis; Rats; Rats, Wistar; Recombinant Proteins; Transforming Growth Factor beta | 2004 |
Cellular mechanisms and modulation of activin A- and transforming growth factor beta-mediated differentiation in cultured hen granulosa cells.
Topics: Activins; Animals; Cell Differentiation; Cells, Cultured; Chickens; Drug Combinations; Female; Follicle Stimulating Hormone; Granulosa Cells; Humans; Inhibin-beta Subunits; Mitogen-Activated Protein Kinases; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors.
Topics: Activins; Animals; Cell Membrane; Ligands; Mice; Protein Structure, Tertiary; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2004 |
Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Proliferation; Cells, Cultured; Dental Enamel; Epithelium; Follistatin; In Situ Hybridization; Keratin-14; Keratins; Mice; Mice, Knockout; Molar; Morphogenesis; Promoter Regions, Genetic; Signal Transduction; Transforming Growth Factor beta | 2004 |
The signaling pathways in tissue morphogenesis: a lesson from mice with eye-open at birth phenotype.
Topics: Activins; Animals; Cell Movement; Eyelids; Keratinocytes; MAP Kinase Kinase Kinase 1; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Morphogenesis; Phenotype; Signal Transduction; Transforming Growth Factor alpha; Transforming Growth Factor beta | 2004 |
Activin redux: specification of mesodermal pattern in Xenopus by graded concentrations of endogenous activin B.
Topics: Activins; Animals; Body Patterning; Embryonic Induction; Mesoderm; Oligodeoxyribonucleotides, Antisense; Protein Biosynthesis; Transforming Growth Factor beta; Xenopus | 2004 |
Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice.
Topics: Activins; Animals; Cell Division; DNA; DNA-Binding Proteins; Follistatin; Hepatocytes; Inhibin-beta Subunits; Liver Regeneration; Mice; Mice, Knockout; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2004 |
Up-regulation of mouse mast cell protease-6 gene by transforming growth factor-beta and activin in mast cell progenitors.
Topics: Activins; Animals; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Inhibin-beta Subunits; Luciferases; Mast Cells; Mice; Recombinant Fusion Proteins; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Endopeptidases; Stem Cells; Transforming Growth Factor beta; Tryptases | 2005 |
Maintenance of mouse trophoblast stem cell proliferation by TGF-beta/activin.
Topics: Activins; Animals; Cell Division; Fibroblast Growth Factor 4; Fibroblast Growth Factors; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Transforming Growth Factor beta; Trophoblasts | 2004 |
Cloning and expression of an SH3 domain-containing protein (Xchef-1), a novel downstream target of activin/nodal signaling.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Cloning, Molecular; DNA, Complementary; Gastrula; Gene Expression Regulation, Developmental; Hemagglutinins, Viral; Intracellular Signaling Peptides and Proteins; Models, Genetic; Molecular Sequence Data; Neural Crest; Nodal Protein; Oligonucleotide Array Sequence Analysis; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; src Homology Domains; Transcription, Genetic; Transforming Growth Factor beta; Viral Fusion Proteins; Xenopus; Xenopus Proteins | 2004 |
Adenoviral gene transfer allows Smad-responsive gene promoter analyses and delineation of type I receptor usage of transforming growth factor-beta family ligands in cultured human granulosa luteal cells.
Topics: Activin Receptors, Type I; Activins; Adenoviridae; Bone Morphogenetic Protein 15; Cells, Cultured; DNA-Binding Proteins; Female; Gene Transfer, Horizontal; Growth Differentiation Factor 9; Humans; Inhibins; Intercellular Signaling Peptides and Proteins; Ligands; Luteal Cells; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta | 2005 |
Visualizing long-range movement of the morphogen Xnr2 in the Xenopus embryo.
Topics: Activins; Animals; Blotting, Western; Diffusion; DNA Primers; Fluorescence; Green Fluorescent Proteins; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Microscopy, Confocal; Morphogenesis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2004 |
Regulation of follicle-stimulating hormone-receptor messenger RNA in hen granulosa cells relative to follicle selection.
Topics: Activins; Animals; Chickens; Corpus Luteum; Female; Granulosa Cells; Humans; Inhibin-beta Subunits; Mitogen-Activated Protein Kinases; Models, Animal; Ovulation; Receptors, FSH; Recombinant Proteins; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2005 |
GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos.
Topics: Activins; Animals; Cycloheximide; DNA-Binding Proteins; Embryo, Nonmammalian; Emetine; Endoderm; GATA4 Transcription Factor; GATA5 Transcription Factor; GATA6 Transcription Factor; Gene Expression Regulation, Developmental; High Mobility Group Proteins; Liver; Protein Biosynthesis; Protein Synthesis Inhibitors; Signal Transduction; SOXF Transcription Factors; Transcription Factors; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2005 |
Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis.
Topics: Activins; Animals; Cells, Cultured; Disease Models, Animal; Enalapril; Fibroblast Growth Factor 2; Gene Expression Regulation; Glomerular Mesangium; Inflammation; Inhibin-beta Subunits; Interleukin-1; Male; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.
Topics: Activins; Animals; Benzamides; Blastocyst; Dioxoles; DNA-Binding Proteins; Humans; Mice; Nodal Protein; Phosphoproteins; Pluripotent Stem Cells; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad5 Protein; Trans-Activators; Transforming Growth Factor beta | 2005 |
Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.
Topics: Acetylation; Activins; Animals; Bone Morphogenetic Proteins; Cell Line; CREB-Binding Protein; DNA; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Histones; Humans; MDS1 and EVI1 Complex Locus Protein; Nuclear Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Binding; Proto-Oncogenes; Smad3 Protein; Trans-Activators; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Xenopus | 2005 |
Human endometrial leukemia inhibitory factor and interleukin-6: control of secretion by transforming growth factor-beta-related members.
Topics: Activins; Adolescent; Adult; Dose-Response Relationship, Drug; Embryo Implantation; Endometrium; Epithelial Cells; Female; Humans; Immune Tolerance; Inhibin-beta Subunits; Inhibins; Interleukin-6; Leukemia Inhibitory Factor; Middle Aged; Pregnancy; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Transforming Growth Factor beta3 | 2005 |
Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.
Topics: Activins; Amino Acids; Cells, Cultured; Collagen Type I; Cross-Linking Reagents; Cytokines; Fibroblasts; Fibrosis; Gene Expression Regulation, Enzymologic; Humans; Inhibin-beta Subunits; Interleukin-4; Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase; Protein Isoforms; RNA, Messenger; Skin; Time Factors; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Transcriptional regulation of plasminogen activator inhibitor-1 by transforming growth factor-beta, activin A and microphthalmia-associated transcription factor.
Topics: Activins; Animals; Cell Line; Cells, Cultured; E-Box Elements; Inhibin-beta Subunits; Mast Cells; Melanocytes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microphthalmia-Associated Transcription Factor; Plasminogen Activator Inhibitor 1; Protein Isoforms; RNA, Messenger; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Attenuation of bleomycin-induced pulmonary fibrosis by follistatin.
Topics: Activin Receptors; Activins; Animals; Bleomycin; Cell Differentiation; Cells, Cultured; Collagen; Fibroblasts; Follistatin; Humans; Inhibin-beta Subunits; Lung; Pulmonary Fibrosis; Rats; Rats, Wistar; Recombinant Proteins; Transforming Growth Factor beta; Up-Regulation | 2005 |
Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin--in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist.
Topics: Actins; Activins; Animals; Blastoderm; Blastula; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Carrier Proteins; Chick Embryo; Embryonic Induction; Follistatin; Glycoproteins; Intercellular Signaling Peptides and Proteins; Left-Right Determination Factors; Muscle, Smooth; Myocytes, Cardiac; Nodal Protein; Transforming Growth Factor beta | 2005 |
Structural and functional evidence for a singular repertoire of BMP receptor signal transducing proteins in the lophotrochozoan Crassostrea gigas suggests a shared ancestral BMP/activin pathway.
Topics: Activin Receptors, Type I; Activins; Amino Acid Sequence; Animals; Biological Evolution; Body Patterning; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; DNA-Binding Proteins; Gene Expression Regulation, Developmental; Genes, Dominant; Larva; Mesoderm; Molecular Sequence Data; Neoplasm Proteins; Ostreidae; Phenotype; Phylogeny; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Growth Factor; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Zebrafish | 2005 |
Left-right asymmetry in the sea urchin embryo is regulated by nodal signaling on the right side.
Topics: Activins; Animals; Body Patterning; Ectoderm; Embryo, Nonmammalian; Gastrula; Homeobox Protein PITX2; Homeodomain Proteins; Left-Right Determination Factors; Molecular Sequence Data; Nodal Protein; Sea Urchins; Signal Transduction; Transcription Factors; Transforming Growth Factor beta | 2005 |
Activin A inhibits formation of skeletal muscle during chick development.
Topics: Activins; Animals; Apoptosis; Cell Differentiation; Chick Embryo; DNA-Binding Proteins; Down-Regulation; Embryonic Development; Extremities; Gene Expression Regulation, Developmental; Growth Inhibitors; Homeodomain Proteins; Inhibin-beta Subunits; Mesoderm; Muscle Proteins; Muscle, Skeletal; Myoblasts, Skeletal; MyoD Protein; Myogenic Regulatory Factor 5; Myostatin; Paired Box Transcription Factors; PAX3 Transcription Factor; PAX7 Transcription Factor; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 2005 |
The activin signaling pathway promotes differentiation of dI3 interneurons in the spinal neural tube.
Topics: Activin Receptors, Type I; Activins; Animals; Body Patterning; Bone Morphogenetic Proteins; Cell Differentiation; Chick Embryo; Gene Expression Regulation, Developmental; Interneurons; Multipotent Stem Cells; Signal Transduction; Spinal Cord; Transforming Growth Factor beta | 2005 |
Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors.
Topics: Activins; Animals; Blotting, Northern; Cell Line, Tumor; Chromatin Immunoprecipitation; COS Cells; DNA-Binding Proteins; Down-Regulation; Female; Gene Expression Regulation; Gene Expression Regulation, Developmental; Glutathione Transferase; Goosecoid Protein; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Immunoblotting; Immunoprecipitation; Luciferases; Mice; Microscopy, Fluorescence; Models, Biological; Nodal Protein; Oligonucleotides, Antisense; Plasmids; Promoter Regions, Genetic; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA; Signal Transduction; Smad2 Protein; Time Factors; Trans-Activators; Transcription Factors; Transcription Factors, TFII; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta; Up-Regulation; Xenopus; Xenopus laevis; Xenopus Proteins | 2005 |
Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells.
Topics: Activins; Animals; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Eye Proteins; Genetic Vectors; Homeobox Protein SIX3; Homeodomain Proteins; Immunohistochemistry; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Left-Right Determination Factors; Lentivirus; Mice; Nerve Tissue Proteins; Paired Box Transcription Factors; PAX6 Transcription Factor; Repressor Proteins; Retina; Rhodopsin; Serum; Stem Cells; Transforming Growth Factor beta | 2005 |
Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors.
Topics: Activins; Animals; Cell Differentiation; Fetus; Hepatocyte Nuclear Factor 6; Hepatocytes; Homeodomain Proteins; Mice; Mice, Knockout; Mice, Transgenic; Signal Transduction; Trans-Activators; Transcription Factors; Transforming Growth Factor beta | 2005 |
The G protein-coupled receptor kinase-2 is a TGFbeta-inducible antagonist of TGFbeta signal transduction.
Topics: Active Transport, Cell Nucleus; Activins; Animals; Apoptosis; beta-Adrenergic Receptor Kinases; Cell Nucleus; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; G-Protein-Coupled Receptor Kinase 2; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Norepinephrine; Phosphorylation; Protein Binding; Rats; Signal Transduction; Smad2 Protein; Smad3 Protein; Substrate Specificity; Trans-Activators; Transforming Growth Factor beta | 2005 |
An activin-A/C chimera exhibits activin and myostatin antagonistic properties.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Amino Acid Sequence; Animals; beta-Galactosidase; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cells, Cultured; Follicle Stimulating Hormone; Follistatin; Humans; Kidney; Ligands; Male; Mice; Molecular Sequence Data; Mutagenesis; Myostatin; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Transforming Growth Factor beta | 2005 |
Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture.
Topics: Activins; Animals; Cadherins; Cell Differentiation; Cell Line; Cell Lineage; Culture Media, Serum-Free; Endoderm; Gene Expression Regulation, Developmental; Goosecoid Protein; Green Fluorescent Proteins; Mesoderm; Mice; Multipotent Stem Cells; Nodal Protein; Receptor, Platelet-Derived Growth Factor alpha; Recombinant Fusion Proteins; Transforming Growth Factor beta | 2005 |
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells.
Topics: Activin Receptors, Type I; Activins; Animals; Benzamides; Biomarkers; Cell Differentiation; Cells, Cultured; Dioxoles; Embryo, Mammalian; Epidermal Growth Factor; Fibroblast Growth Factors; GPI-Linked Proteins; Humans; Intercellular Signaling Peptides and Proteins; Membrane Glycoproteins; Mice; Neoplasm Proteins; Nodal Protein; Pluripotent Stem Cells; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Structural basis for a functional antagonist in the transforming growth factor beta superfamily.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Binding, Competitive; Blotting, Western; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; DNA Mutational Analysis; Glycosylation; Immunoprecipitation; Inhibin-beta Subunits; Inhibins; Ligands; Luciferases; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Multigene Family; Mutagenesis; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta | 2005 |
The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding.
Topics: Activin Receptors, Type I; Activins; Amino Acid Sequence; Animals; Binding Sites; Cricetinae; Crystallography, X-Ray; Follistatin; Inhibin-beta Subunits; Ligands; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Sequence Alignment; Transforming Growth Factor beta | 2005 |
Transforming growth factor beta1 regulates follistatin mRNA expression during in vitro bovine granulosa cell differentiation.
Topics: Activin Receptors, Type II; Activins; Animals; Binding, Competitive; Cattle; Cell Differentiation; Cell Line; Cells, Cultured; Culture Media, Conditioned; Female; Fibronectins; Follistatin; Gene Expression; Granulosa Cells; Humans; Inhibin-beta Subunits; Progesterone; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
A cell cycle arrest is necessary for bottle cell formation in the early Xenopus gastrula: integrating cell shape change, local mitotic control and mesodermal patterning.
Topics: Activins; Animals; Body Patterning; cdc25 Phosphatases; Cell Cycle; Cell Shape; Embryo, Nonmammalian; Fibroblast Growth Factors; Gastrula; Goosecoid Protein; Growth Inhibitors; Mesoderm; Mitosis; T-Box Domain Proteins; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2005 |
A road map toward defining the role of Smad signaling in hematopoietic stem cells.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line; Cell Proliferation; Cells, Cultured; Hematopoietic Stem Cells; Inhibin-beta Subunits; Ligands; Mice; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Control of hepatic differentiation by activin/TGFbeta signaling.
Topics: Activins; Cell Differentiation; Hepatocytes; Humans; Liver; Signal Transduction; Transforming Growth Factor beta | 2006 |
Differential regulation of follicle stimulating hormone by activin A and TGFB1 in murine gonadotropes.
Topics: Activins; Animals; Cells, Cultured; Female; Follicle Stimulating Hormone; Follicle Stimulating Hormone, beta Subunit; Gene Expression Regulation; Inhibin-beta Subunits; Male; Mice; Pituitary Gland; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
Activin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma.
Topics: Activins; Animals; Asthma; CD4-Positive T-Lymphocytes; Humans; Immunohistochemistry; Inhibin-beta Subunits; Lymphocyte Activation; Mice; Mice, Inbred BALB C; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Drosophila melanogaster; Drosophila Proteins; Larva; Metamorphosis, Biological; Morphogenesis; Mutation; Neurons; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta | 2006 |
Structural basis for the inhibition of activin signalling by follistatin.
Topics: Activin Receptors, Type II; Activins; Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Embryo, Mammalian; Embryo, Nonmammalian; Follistatin; Humans; Inhibin-beta Subunits; Ligands; Models, Molecular; Molecular Sequence Data; Mutation; Protein Binding; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Signal Transduction; Transforming Growth Factor beta; Xenopus laevis | 2006 |
Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line.
Topics: Activins; Adrenal Cortex; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Cell Line; Inhibins; Mice; Rats; Steroid 17-alpha-Hydroxylase; Transforming Growth Factor beta | 2006 |
Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Chlorocebus aethiops; COS Cells; Follistatin; Follistatin-Related Proteins; Humans; Myostatin; Recombinant Proteins; Transforming Growth Factor beta | 2006 |
Cell-specificity of transforming growth factor-beta response is dictated by receptor bioavailability.
Topics: Activin Receptors, Type I; Activins; Animals; Cell Line; Female; Follicle Stimulating Hormone, beta Subunit; Gene Expression Regulation; Gonadotrophs; Humans; Mice; Protein Isoforms; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Smad3 Protein; Transcription, Genetic; Transforming Growth Factor beta | 2006 |
Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner.
Topics: Activins; Animals; Blotting, Western; Cell Line; CHO Cells; Cricetinae; Enzyme Activation; Gene Expression; Humans; Luciferases; Mutagenesis; p38 Mitogen-Activated Protein Kinases; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Rats; Recombinant Fusion Proteins; Smad Proteins, Receptor-Regulated; Transcription Factor Pit-1; Transfection; Transforming Growth Factor beta | 2006 |
Cg-TGF-beta, a TGF-beta/activin homologue in the Pacific Oyster Crassostrea gigas, is involved in immunity against Gram-negative microbial infection.
Topics: Activins; Amino Acid Sequence; Animals; Crassostrea; Cytokines; Gene Expression Regulation; Gram-Negative Bacterial Infections; Molecular Sequence Data; Transforming Growth Factor beta | 2007 |
Follistatin rescues the inhibitory effect of activin A on the differentiation of bovine preadipocyte.
Topics: Activins; Adipocytes; Adipose Tissue; Animals; Cattle; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Drug Interactions; Follistatin; Glycerolphosphate Dehydrogenase; Male; Myostatin; PPAR gamma; RNA, Messenger; Transforming Growth Factor beta | 2007 |
Transforming growth factor-beta1 and activin A generate antiproliferative signaling in thyroid cancer cells.
Topics: Activins; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, myc; Humans; Immunohistochemistry; Inhibin-beta Subunits; Polymerase Chain Reaction; Recombinant Proteins; RNA, Small Interfering; Signal Transduction; Smad Proteins; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Thyroid Neoplasms; Transfection; Transforming Growth Factor beta | 2006 |
Requirement of Smad3 for mast cell growth.
Topics: Activins; Animals; Bone Marrow Cells; Cell Cycle; Cell Division; Cells, Cultured; Culture Media, Conditioned; Gene Expression Regulation; Inhibin-beta Subunits; Mast Cells; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-kit; Receptors, IgE; RNA, Messenger; Smad3 Protein; Tetrazolium Salts; Thiazoles; Transforming Growth Factor beta | 2006 |
Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation.
Topics: Activins; Animals; Embryo, Nonmammalian; Gastrula; Gene Expression Regulation, Developmental; Neurons; Nodal Protein; POU Domain Factors; RNA; Signal Transduction; Transforming Growth Factor beta; Xenopus laevis | 2006 |
Identification of tocopherol-associated protein as an activin/TGF-beta-inducible gene in mast cells.
Topics: Activin Receptors, Type I; Activins; Animals; Benzamides; Carrier Proteins; Cell Line; Cells, Cultured; Dioxoles; DNA, Complementary; Gene Expression Regulation; Inhibin-beta Subunits; Lipoproteins; MAP Kinase Signaling System; Mast Cells; Mice; Oligonucleotide Array Sequence Analysis; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Function of the two Xenopus smad4s in early frog development.
Topics: Activins; Animals; Arginine; Gene Expression Regulation, Developmental; Histidine; Mesoderm; Mutation, Missense; Nerve Growth Factors; Neurons; Point Mutation; Signal Transduction; Smad Proteins; Smad4 Protein; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2006 |
Molecular basis of oocyte-paracrine signalling that promotes granulosa cell proliferation.
Topics: Activins; Animals; Bone Morphogenetic Protein 15; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Proliferation; DNA; Female; Gene Expression Regulation; Granulosa Cells; Growth Differentiation Factor 9; Intercellular Signaling Peptides and Proteins; Mice; Oocytes; Paracrine Communication; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2006 |
Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling.
Topics: Activins; Animals; Blood Vessels; Cell Nucleus; Cell Survival; DNA-Binding Proteins; Embryo, Mammalian; Embryo, Nonmammalian; Genes, Lethal; Membrane Proteins; Mice; Mice, Mutant Strains; Mutation; Neovascularization, Physiologic; Nodal Protein; Nuclear Envelope; Nuclear Proteins; Sequence Deletion; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation; Xenopus; Xenopus Proteins | 2006 |
Wnt and TGF-beta signaling are required for the induction of an in vitro model of primitive streak formation using embryonic stem cells.
Topics: Activins; Animals; CD4 Antigens; Cell Line; Embryonic Induction; Embryonic Stem Cells; Female; Fetal Proteins; Gene Expression Regulation, Developmental; Gene Targeting; Green Fluorescent Proteins; Hepatocyte Nuclear Factor 3-beta; Humans; Male; Mice; Mice, Transgenic; Models, Biological; Pregnancy; Signal Transduction; T-Box Domain Proteins; Transforming Growth Factor beta; Wnt Proteins | 2006 |
The divergent TGF-beta ligand Dawdle utilizes an activin pathway to influence axon guidance in Drosophila.
Topics: Activin Receptors; Activin Receptors, Type I; Activin Receptors, Type II; Activins; Amino Acid Sequence; Animals; Axons; Base Sequence; Carrier Proteins; Cell Movement; Drosophila; Drosophila Proteins; Embryo, Nonmammalian; Embryonic Development; Gene Expression Regulation, Developmental; Growth Cones; Ligands; Molecular Sequence Data; Motor Neurons; Muscles; Mutation; Neuroglia; Sequence Alignment; Signal Transduction; Smad2 Protein; Transcription, Genetic; Transforming Growth Factor beta | 2006 |
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells.
Topics: Activins; Animals; Autocrine Communication; Benzamides; Cell Division; Chimera; Culture Media, Serum-Free; Dioxoles; Embryonic Stem Cells; Mice; Mice, Inbred C57BL; Mice, Nude; Nodal Protein; Protein Kinase Inhibitors; Signal Transduction; Smad6 Protein; Smad7 Protein; Teratoma; Transforming Growth Factor beta; Tumor Cells, Cultured | 2007 |
Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion.
Topics: Activin Receptors; Activins; Animals; Benzamides; Blotting, Western; Cell Proliferation; Dioxoles; Female; Granulosa Cells; Mice; Oocytes; Paracrine Communication; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad3 Protein; Transcription, Genetic; Transforming Growth Factor beta | 2007 |
The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway.
Topics: Activins; Amino Acid Sequence; Animals; Binding Sites; Calcium-Binding Proteins; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Cells, Cultured; Evolution, Molecular; Intercellular Signaling Peptides and Proteins; Mice; Molecular Sequence Data; Neurons; Protein Structure, Tertiary; Receptor, Notch1; Sequence Homology, Amino Acid; Signal Transduction; Smad Proteins; Stem Cells; Transcription, Genetic; Transforming Growth Factor beta | 2007 |
Kinesin-mediated transport of Smad2 is required for signaling in response to TGF-beta ligands.
Topics: Activins; Animals; Cell Nucleus; Embryo, Nonmammalian; Green Fluorescent Proteins; Humans; Kinesins; Ligands; Mice; Microtubule-Associated Proteins; Microtubules; NIH 3T3 Cells; Nodal Protein; Phosphorylation; Protein Binding; Protein Transport; Recombinant Fusion Proteins; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Xenopus; Zebrafish | 2007 |
Bone morphogenetic protein 2 and activin A synergistically stimulate follicle-stimulating hormone beta subunit transcription.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Line, Transformed; Follicle Stimulating Hormone, beta Subunit; Gene Expression Regulation; Humans; Mice; Transcription, Genetic; Transforming Growth Factor beta | 2007 |
Ovarian epithelial inclusion cysts in chronically superovulated CD1 and Smad2 dominant-negative mice.
Topics: Activins; Animals; Cell Division; Chronic Disease; Epithelial Cells; Female; Gonadotropins, Equine; Mice; Mice, Inbred Strains; Mice, Transgenic; Ovarian Cysts; Ovarian Neoplasms; Ovulation; Phosphorylation; Signal Transduction; Smad2 Protein; Superovulation; Transforming Growth Factor beta | 2007 |
N-linked oligosaccharides direct the differential assembly and secretion of inhibin alpha- and betaA-subunit dimers.
Topics: Activins; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Dimerization; DNA Primers; Evolution, Molecular; Glycosylation; Inhibin-beta Subunits; Inhibins; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligosaccharides; Protein Structure, Quaternary; Subcellular Fractions; Transforming Growth Factor beta; Tunicamycin | 2007 |
Directed differentiation of human embryonic stem cells into functional hepatic cells.
Topics: Activins; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Culture Media, Serum-Free; Embryonic Stem Cells; Fibroblast Growth Factor 4; Hepacivirus; Hepatocytes; HIV; Humans; Transforming Growth Factor beta | 2007 |
Acetylation of Smad2 by the co-activator p300 regulates activin and transforming growth factor beta response.
Topics: Activins; Amino Acid Sequence; Animals; Cell Nucleus; Fibroblasts; Humans; Mice; Molecular Sequence Data; NIH 3T3 Cells; p300-CBP Transcription Factors; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2007 |
Cross-talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell-specific outcomes.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Receptors, Notch; Signal Transduction; Smad Proteins; Toll-Like Receptors; Transforming Growth Factor beta | 2007 |
Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.
Topics: Activins; Animals; Cell Line; Down-Regulation; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Goosecoid Protein; Histone Deacetylases; Homeodomain Proteins; Humans; Mice; Mice, Knockout; Nodal Protein; Promoter Regions, Genetic; Protein Binding; Smad Proteins; Time Factors; Transcription, Genetic; Transcriptional Activation; Transforming Growth Factor beta | 2007 |
Environmental and genetic modifiers of squint penetrance during zebrafish embryogenesis.
Topics: Activins; Animals; Base Sequence; DNA; Environment; Female; HSP90 Heat-Shock Proteins; Mutation; Nodal Protein; Nodal Signaling Ligands; Penetrance; Phenotype; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins; Zygote | 2007 |
TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis.
Topics: Activins; Animals; Base Sequence; Cadherins; Cell Adhesion; DNA, Complementary; Endocytosis; Gene Expression Regulation, Developmental; In Situ Hybridization; Membrane Proteins; Morphogenesis; Mutation; Nodal Protein; Phenotype; Receptors, Fibroblast Growth Factor; rho GTP-Binding Proteins; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2007 |
The role of maternal Activin-like signals in zebrafish embryos.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Animals; Benzodioxoles; Body Patterning; Endoderm; Imidazoles; Mesoderm; Mutation; Nodal Signaling Ligands; Pyridines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins | 2007 |
MicroRNA control of Nodal signalling.
Topics: Activin Receptors, Type II; Activins; Animals; beta Catenin; Body Patterning; Gene Expression Regulation, Developmental; MicroRNAs; Nodal Protein; Organizers, Embryonic; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins; Xenopus laevis | 2007 |
XSUMO-1 is required for normal mesoderm induction and axis elongation during early Xenopus development.
Topics: Activins; Animals; beta Catenin; Body Patterning; Embryonic Induction; Gene Expression Regulation, Developmental; Mesoderm; Nodal Protein; Signal Transduction; Smad Proteins; SUMO-1 Protein; Transforming Growth Factor beta; Wnt Proteins; Xenopus laevis; Xenopus Proteins | 2007 |
Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development.
Topics: Activins; Animals; Base Sequence; Cell Line; DNA Primers; Female; Fetal Heart; Follistatin-Related Proteins; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Hybridization; Mice; Mice, Inbred ICR; Myostatin; Pregnancy; Proteins; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2007 |
Developmental changes in extracellular matrix messenger RNAs in the mouse placenta during the second half of pregnancy: possible factors involved in the regulation of placental extracellular matrix expression.
Topics: Activins; Animals; Cell Culture Techniques; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type IV; Extracellular Matrix; Female; Fetal Development; Fibronectins; Gene Expression Regulation, Developmental; Glucose; Mice; Mice, Inbred C57BL; Organ Size; Oxygen; Placenta; Placentation; Pregnancy; Pregnancy, Animal; Receptors, Transforming Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta | 2007 |
Regulation of the response to Nodal-mediated mesoderm induction by Xrel3.
Topics: Activins; Animals; Biomarkers; Embryonic Induction; Fibroblast Growth Factor 2; Gene Expression Regulation, Developmental; Genes, Reporter; Humans; Mesoderm; NF-kappa B; Nodal Protein; Oligonucleotides, Antisense; Oocytes; T-Box Domain Proteins; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2007 |
Hes6 is required for MyoD induction during gastrulation.
Topics: Activins; Animals; Body Patterning; Co-Repressor Proteins; DNA-Binding Proteins; Embryo, Nonmammalian; Fibroblast Growth Factors; Gastrulation; Gene Expression Regulation, Developmental; MAP Kinase Signaling System; Mesoderm; Muscle Development; MyoD Protein; Nodal Protein; Oligonucleotides, Antisense; Protein Binding; Repressor Proteins; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2007 |
Activin regulates estrogen receptor gene expression in the mouse ovary.
Topics: Activins; Animals; Anti-Mullerian Hormone; Autocrine Communication; Cells, Cultured; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; Mice; Mice, Transgenic; Paracrine Communication; Pituitary Gland; Promoter Regions, Genetic; Protein Synthesis Inhibitors; RNA, Messenger; Signal Transduction; Smad2 Protein; Smad3 Protein; Time Factors; Transcription, Genetic; Transforming Growth Factor beta | 2007 |
Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm.
Topics: Activins; Cell Differentiation; Cell Lineage; Embryonic Stem Cells; Humans; Left-Right Determination Factors; Neurons; Nodal Protein; Pluripotent Stem Cells; Signal Transduction; Transforming Growth Factor beta | 2008 |
Smad signaling antagonizes STAT5-mediated gene transcription and mammary epithelial cell differentiation.
Topics: Activins; Animals; Caseins; Cell Differentiation; Cell Nucleus; Cyclin D1; Epithelial Cells; Female; Gene Expression Regulation; Humans; Janus Kinases; Mammary Glands, Animal; Milk Proteins; p300-CBP Transcription Factors; Phosphorylation; Prolactin; Promoter Regions, Genetic; Protein Binding; Protein Transport; Repressor Proteins; Signal Transduction; Smad Proteins; STAT5 Transcription Factor; Thermodynamics; Transcription, Genetic; Transforming Growth Factor beta | 2008 |
smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish.
Topics: Activins; Amino Acid Substitution; Animals; Animals, Genetically Modified; Body Patterning; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Genes, Dominant; Mesoderm; Nodal Protein; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Zebrafish; Zebrafish Proteins | 2008 |
Levels of Smad7 regulate Smad and mitogen activated kinases (MAPKs) signaling and controls erythroid and megakaryocytic differentiation of erythroleukemia cells.
Topics: Activins; Autocrine Communication; Cell Differentiation; Erythroid Cells; Gene Expression Regulation; Humans; K562 Cells; Leukemia, Erythroblastic, Acute; MAP Kinase Signaling System; Megakaryocytes; Signal Transduction; Smad Proteins; Smad7 Protein; Transforming Growth Factor beta | 2007 |
Activin A/bone morphogenetic protein (BMP) chimeras exhibit BMP-like activity and antagonize activin and myostatin.
Topics: Activins; Amino Acid Sequence; Animals; Bone Morphogenetic Proteins; Cell Line; Electrophoresis, Polyacrylamide Gel; Molecular Sequence Data; Myostatin; Rats; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Smad Proteins; Transforming Growth Factor beta | 2008 |
Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal.
Topics: Activin Receptors; Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Binding Sites; Epidermal Growth Factor; GPI-Linked Proteins; Homeodomain Proteins; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Membrane Glycoproteins; Membrane Proteins; Mice; Multiprotein Complexes; Neoplasm Proteins; Nodal Protein; Signal Transduction; Transcription Factors; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2008 |
Activin-A: a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production.
Topics: Activins; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; CD40 Ligand; CD8-Positive T-Lymphocytes; Cell Proliferation; Cell Separation; Chemokines; Dendritic Cells; Epitopes; Follistatin; Gene Expression Regulation; Humans; Lipopolysaccharides; Myostatin; Receptors, Cell Surface; Transforming Growth Factor beta | 2008 |
Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity.
Topics: Activins; Animals; Body Patterning; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Differentiation; Embryonic Stem Cells; Fibroblast Growth Factors; Mesoderm; Mice; Nodal Protein; Signal Transduction; Transforming Growth Factor beta | 2008 |
TGFbeta/Activin/Nodal pathway in inhibition of human embryonic stem cell differentiation by mechanical strain.
Topics: Activins; Apoptosis; Cell Differentiation; Cell Survival; Cells, Cultured; Elasticity; Embryonic Stem Cells; Humans; Mechanotransduction, Cellular; Nodal Protein; Shear Strength; Signal Transduction; Stress, Mechanical; Transforming Growth Factor beta | 2008 |
The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cells, Cultured; Female; Follicle Stimulating Hormone; Gonadotropins, Pituitary; Growth Differentiation Factor 9; Homozygote; Intercellular Signaling Peptides and Proteins; Mutation; Ovulation; Pituitary Gland; Sheep; Tissue Distribution; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2008 |
Activin/nodal signaling modulates XPAPC expression during Xenopus gastrulation.
Topics: Activins; Animals; Cadherins; Gastrula; Gastrulation; Gene Expression Regulation, Developmental; Morphogenesis; Nodal Protein; Protocadherins; Repressor Proteins; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Wnt Proteins; Xenopus laevis; Xenopus Proteins | 2008 |
Regulation of human B lymphopoiesis by the transforming growth factor-beta superfamily in a newly established coculture system using human mesenchymal stem cells as a supportive microenvironment.
Topics: Activins; Antibodies; Antigens, CD34; B-Lymphocytes; Coculture Techniques; Drug Evaluation, Preclinical; Flow Cytometry; Humans; Lymphopoiesis; Mesenchymal Stem Cells; Molecular Weight; Neprilysin; Recombinant Proteins; Reference Values; Transforming Growth Factor beta | 2008 |
Nodal and lefty signaling regulates the growth of pancreatic cells.
Topics: Activins; Animals; Apoptosis; Cell Line; Cell Proliferation; Enzyme Activation; Gene Expression Regulation, Developmental; Interferon-gamma; Islets of Langerhans; Left-Right Determination Factors; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinases; Nodal Protein; Proto-Oncogene Proteins c-akt; Regeneration; Signal Transduction; Transforming Growth Factor beta | 2008 |
Regulation of TGF-(beta) signalling by N-acetylgalactosaminyltransferase-like 1.
Topics: Activin Receptors, Type II; Activins; Animals; Bone Morphogenetic Protein Receptors, Type I; Cell Line; Chlorocebus aethiops; Embryo, Nonmammalian; Glycosylation; Humans; Mesoderm; Mucins; N-Acetylgalactosaminyltransferases; Neural Crest; Polypeptide N-acetylgalactosaminyltransferase; Signal Transduction; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2008 |
Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function.
Topics: Activin Receptors, Type I; Activins; Animals; Calcium; Fatty Liver; Gene Expression Regulation; Hyperinsulinism; Insulin; Insulin-Secreting Cells; Mice; Mice, Transgenic; Models, Biological; Pancreas; Signal Transduction; Transforming Growth Factor beta | 2008 |
Use of xenofree matrices and molecularly-defined media to control human embryonic stem cell pluripotency: effect of low physiological TGF-beta concentrations.
Topics: Activins; Albumins; Animals; Cell Differentiation; Cell Proliferation; Cell Shape; Culture Media; Cytokines; Down-Regulation; Embryonic Stem Cells; Extracellular Matrix; Gene Expression Profiling; Humans; Intercellular Signaling Peptides and Proteins; Karyotyping; Left-Right Determination Factors; Mice; Phenotype; Pluripotent Stem Cells; Transforming Growth Factor beta; Up-Regulation | 2008 |
Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin.
Topics: Activins; Binding, Competitive; Bone Morphogenetic Proteins; Cells, Cultured; Follistatin; Growth Differentiation Factors; Humans; Mutant Proteins; Myostatin; Protein Binding; Protein Structure, Tertiary; Transfection; Transforming Growth Factor beta | 2008 |
Combinatorial signals of activin/nodal and bone morphogenic protein regulate the early lineage segregation of human embryonic stem cells.
Topics: Activins; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Embryonic Development; Embryonic Stem Cells; Humans; Nodal Protein; Pluripotent Stem Cells; Signal Transduction; Transforming Growth Factor beta; Trophoblasts | 2008 |
Regulation of melanin synthesis by the TGF-beta family in B16 melanoma cells.
Topics: Activins; Bone Morphogenetic Protein 2; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Membrane Glycoproteins; Monophenol Monooxygenase; Oxidoreductases; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2009 |
Activin/TGFbeta and BMP crosstalk determines digit chondrogenesis.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Bromodeoxyuridine; Cell Proliferation; Chick Embryo; Chondrogenesis; Extremities; In Situ Hybridization; Signal Transduction; Transforming Growth Factor beta | 2008 |
Regulation of activin/nodal signaling by Rap2-directed receptor trafficking.
Topics: Activin Receptors, Type I; Activins; Animals; Biological Transport; Body Patterning; Cell Line; Cell Nucleus; Embryo, Nonmammalian; Endocytosis; Gene Expression Regulation, Developmental; Genes, Reporter; HeLa Cells; Humans; Kidney; Ligands; Luciferases; Microinjections; Nodal Protein; Oligonucleotides, Antisense; Phosphorylation; rap GTP-Binding Proteins; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad7 Protein; Transfection; Transforming Growth Factor beta; Xenopus; Xenopus Proteins | 2008 |
BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling.
Topics: Activins; Antigens, CD34; Bone Marrow Cells; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Differentiation; Humans; Janus Kinase 1; Megakaryocytes; Models, Biological; Platelet Count; Protein Kinases; Signal Transduction; Thrombopoietin; TOR Serine-Threonine Kinases; Transforming Growth Factor beta; Up-Regulation | 2008 |
Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling.
Topics: Activins; beta Catenin; Bone Morphogenetic Proteins; Cell Differentiation; Cell Lineage; Embryonic Stem Cells; Endoderm; Humans; MAP Kinase Signaling System; Mesoderm; Nodal Protein; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Primitive Streak; Protein Kinase Inhibitors; Signal Transduction; Thermodynamics; Time Factors; Transforming Growth Factor beta; Wnt Proteins | 2008 |
Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Animals; Cell Line; Drosophila; Drosophila Proteins; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Humans; Mice; Nodal Protein; Phenotype; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein Subunits; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Wings, Animal; Xenopus; Xenopus Proteins | 2008 |
Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling.
Topics: Activin Receptors, Type I; Activins; Animals; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Membrane; Embryonic Stem Cells; Endothelial Cells; Gene Expression Profiling; Glycoproteins; Liver; Membrane Transport Proteins; Mice; Phenotype; Transforming Growth Factor beta | 2008 |
Activin A induces Langerhans cell differentiation in vitro and in human skin explants.
Topics: Activins; Antigens, CD; Antigens, CD1; Cell Differentiation; Cells, Cultured; Dendritic Cells; Humans; In Vitro Techniques; Keratinocytes; Langerhans Cells; Lectins, C-Type; Lipopolysaccharide Receptors; Mannose-Binding Lectins; Models, Biological; Monocytes; Skin; Transforming Growth Factor beta; Wound Healing | 2008 |
Role of activin, transforming growth factor-beta and bone morphogenetic protein 15 in regulating zebrafish oocyte maturation.
Topics: Activins; Animals; Bone Morphogenetic Protein 15; Female; Gene Knockdown Techniques; Oocytes; Oogenesis; Smad2 Protein; Transforming Growth Factor beta; Zebrafish | 2009 |
Proteomic identification and functional validation of activins and bone morphogenetic protein 11 as candidate novel muscle mass regulators.
Topics: Activin Receptors, Type II; Activins; Animals; Bone Morphogenetic Proteins; Cells, Cultured; Growth Differentiation Factors; Humans; Immunoglobulin Fc Fragments; Mice; Mice, Inbred BALB C; Muscle Development; Muscles; Organ Size; Protein Binding; Proteomics; Signal Transduction; Transforming Growth Factor beta | 2008 |
Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts.
Topics: Activins; Alkalies; Animals; Basic Helix-Loop-Helix Transcription Factors; Biological Clocks; Cells, Cultured; Circadian Rhythm; Fibroblasts; Gene Expression Regulation; Homeodomain Proteins; Hydrogen-Ion Concentration; Mice; Mice, Inbred C57BL; Rats; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2008 |
Eomesodermin requires transforming growth factor-beta/activin signaling and binds Smad2 to activate mesodermal genes.
Topics: Activins; Amino Acid Sequence; Animals; Antibodies; Binding Sites; Cell Membrane; Gene Expression Regulation, Developmental; Humans; Mesoderm; Molecular Sequence Data; Protein Binding; Sepharose; Sequence Alignment; Signal Transduction; Smad2 Protein; T-Box Domain Proteins; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2009 |
TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch.
Topics: Activins; Animals; Benzamides; Bone Morphogenetic Proteins; Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Dioxoles; Humans; Mice; Phosphorylation; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad1 Protein; Smad5 Protein; Transforming Growth Factor beta | 2009 |
Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells.
Topics: Activins; Cell Adhesion; Cell Line, Tumor; Female; Gene Silencing; Granulosa Cell Tumor; Humans; Inhibins; Ligands; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2009 |
Gene regulatory network interactions in sea urchin endomesoderm induction.
Topics: Activins; Animals; Blastomeres; Cell Adhesion Molecules; Embryonic Development; Embryonic Induction; Gastrula; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Mesoderm; Sea Urchins; Signal Transduction; Transforming Growth Factor beta | 2009 |
Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells.
Topics: Activin Receptors, Type I; Activins; Animals; Blotting, Western; Cadherins; Cell Line, Tumor; DNA Primers; Gene Expression Regulation, Neoplastic; Melanoma, Experimental; Mice; Oligonucleotides; Phosphorylation; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA Interference; RNA, Double-Stranded; Smad2 Protein; Transforming Growth Factor beta | 2010 |
Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.
Topics: Active Transport, Cell Nucleus; Activins; Animals; Base Sequence; Bone Morphogenetic Proteins; Cell Line; Humans; In Vitro Techniques; Models, Biological; Nuclear Proteins; Nucleocytoplasmic Transport Proteins; Phosphorylation; Protein Binding; RNA Interference; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad3 Protein; Transcriptional Activation; Transfection; Transforming Growth Factor beta; Xenopus | 2009 |
Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase.
Topics: Activins; Animals; Cadherins; Cathepsins; Cell Differentiation; Cells, Cultured; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Activation; Extracellular Matrix; Female; Fibroblast Growth Factor 4; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 4; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuropeptides; p38 Mitogen-Activated Protein Kinases; Placenta; Pregnancy; Signal Transduction; Snail Family Transcription Factors; Stem Cells; Transcription Factors; Transforming Growth Factor beta; Trophoblasts; Twist-Related Protein 1 | 2009 |
Pancreatic differentiation from pluripotent stem cells: tweaking the system.
Topics: Activins; Androstadienes; Cell Differentiation; Diabetes Mellitus, Type 1; Embryonic Stem Cells; Epidermal Growth Factor; Humans; Insulin-Secreting Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pluripotent Stem Cells; Transforming Growth Factor beta; Wortmannin | 2009 |
Activin a promotes the TGF-beta-induced conversion of CD4+CD25- T cells into Foxp3+ induced regulatory T cells.
Topics: Activins; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Forkhead Transcription Factors; Interleukin-2 Receptor alpha Subunit; Mice; Mice, Transgenic; p38 Mitogen-Activated Protein Kinases; Smad2 Protein; Transforming Growth Factor beta | 2009 |
Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field.
Topics: Activins; Animals; Body Patterning; Chick Embryo; Gene Expression Regulation, Developmental; Homeodomain Proteins; Kidney; Quail; Signal Transduction; Transforming Growth Factor beta; Tretinoin | 2009 |
Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation.
Topics: Activin Receptors; Activins; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Eosinophils; Epithelial Cells; Female; Humans; Inhibin-beta Subunits; Interleukin-13; Interleukin-5; Metaplasia; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Pneumonia; Recombinant Proteins; Respiratory Mucosa; Signal Transduction; Time Factors; Transforming Growth Factor beta | 2010 |
Analysis of activin/TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas.
Topics: Activins; Adult; Health; Humans; Male; Models, Biological; Seminoma; Signal Transduction; Testicular Diseases; Testicular Neoplasms; Testis; Testosterone; Transforming Growth Factor beta | 2009 |
Molecular cloning of activin type I and type II receptors and differential regulation of their expression by activin in grass carp pituitary cells.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Amino Acid Motifs; Animals; Anura; Carps; Humans; Liver; Mice; Phylogeny; Pituitary Gland; Rats; Sequence Alignment; Transforming Growth Factor beta; Up-Regulation; Zebrafish | 2010 |
BMP signaling induces cell-type-specific changes in gene expression programs of human keratinocytes and fibroblasts.
Topics: Activins; Bone Morphogenetic Proteins; Cell Adhesion; Cells, Cultured; Extracellular Matrix; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation; Humans; Keratinocytes; Ligands; Models, Biological; Oligonucleotide Array Sequence Analysis; Signal Transduction; Transforming Growth Factor beta | 2010 |
Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate.
Topics: Activin Receptors; Activins; Animals; Biomarkers; Cell Differentiation; Cell Lineage; Cells, Cultured; Culture Media, Conditioned; Ear, Inner; Embryo, Mammalian; Epidermal Growth Factor; Female; Fibroblast Growth Factor 4; Gene Expression Regulation, Developmental; Inhibins; Male; Membrane Glycoproteins; Mice; Microarray Analysis; Neoplasm Proteins; Nodal Protein; Paracrine Communication; Placenta; Pregnancy; Stem Cells; Transforming Growth Factor beta; Trophoblasts | 2009 |
Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Adult; Allergens; Asthma; Bronchial Provocation Tests; Cell Proliferation; Cells, Cultured; Cytokines; Epithelial Cells; Follistatin; Humans; Interleukin-13; Middle Aged; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2009 |
Temporal mRNA expression of transforming growth factor-beta superfamily members and inhibitors in the developing rainbow trout ovary.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Estradiol; Female; Fish Proteins; Follistatin; Gene Expression; Growth Differentiation Factors; Inhibin-beta Subunits; Membrane Proteins; Oncorhynchus mykiss; Ovary; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta | 2010 |
Sense and serendipity aid RPE generation.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Cell Differentiation; Cell Line; Cell Transplantation; Embryonic Stem Cells; Epithelial Cells; Fibroblast Growth Factor 2; Humans; Rats; Retinal Pigment Epithelium; Transforming Growth Factor beta | 2009 |
Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Cell Differentiation; Cell Line; Cell Transplantation; Embryonic Stem Cells; Epithelial Cells; Fibroblast Growth Factor 2; Flow Cytometry; Humans; Immunophenotyping; Microscopy, Electron, Transmission; Microscopy, Phase-Contrast; Polymerase Chain Reaction; Rats; Retinal Pigment Epithelium; Transforming Growth Factor beta | 2009 |
TGF-beta superfamily enhances the antigen-induced IFN-gamma production by effector/memory CD8+ T cells.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; CD8-Positive T-Lymphocytes; Clone Cells; Interferon-gamma; Lymphocyte Activation; Mice; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Silver; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2010 |
Inhibitor of differentiation (Id) genes are expressed in the steroidogenic cells of the ovine ovary and are differentially regulated by members of the transforming growth factor-beta family.
Topics: Activins; Animals; Cell Differentiation; Female; Inhibitor of Differentiation Proteins; Ovarian Follicle; Sheep; Smad Proteins; Transforming Growth Factor beta | 2010 |
Integrative genomic analyses of CXCR4: transcriptional regulation of CXCR4 based on TGFbeta, Nodal, Activin signaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1 transcription factors.
Topics: Activins; Animals; Base Sequence; Comparative Genomic Hybridization; Conserved Sequence; DNA-Binding Proteins; Forkhead Transcription Factors; Gene Expression; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Mice; Molecular Sequence Data; Neoplasms; Nodal Protein; Octamer Transcription Factor-3; Promoter Regions, Genetic; Rats; Receptors, CXCR4; Signal Transduction; SOXF Transcription Factors; Stem Cells; Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta | 2010 |
BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.
Topics: Activins; Afferent Pathways; Animals; Bone Morphogenetic Protein 7; Cells, Cultured; Disease Models, Animal; Enkephalins; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Knockout; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nerves; Peripheral Nervous System Diseases; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, delta; Sciatic Neuropathy; Signal Transduction; Spinal Cord; Transforming Growth Factor beta; Up-Regulation | 2010 |
TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.
Topics: Activins; Animals; Cell Line; Chlorocebus aethiops; COS Cells; Embryo, Nonmammalian; Embryonic Development; Humans; Membrane Proteins; Mesoderm; Mice; Models, Biological; NIH 3T3 Cells; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta; Xenopus | 2010 |
BMP-3 promotes mesenchymal stem cell proliferation through the TGF-beta/activin signaling pathway.
Topics: 3T3-L1 Cells; Activins; Adipocytes; Animals; Benzamides; Bone Morphogenetic Protein 3; Cell Differentiation; Cell Lineage; Cell Proliferation; Dioxoles; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Humans; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta | 2010 |
Enhanced differentiation of human embryonic stem cells to mesenchymal progenitors by inhibition of TGF-beta/activin/nodal signaling using SB-431542.
Topics: Activins; Adipogenesis; Animals; Benzamides; Biomarkers; Cell Differentiation; Cells, Cultured; Dioxoles; Ectoderm; Embryo, Mammalian; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Humans; Mesenchymal Stem Cells; Mice; Multipotent Stem Cells; Muscles; Nodal Protein; Oligonucleotide Array Sequence Analysis; Osteogenesis; Signal Transduction; Stem Cell Transplantation; Transforming Growth Factor beta; Up-Regulation | 2010 |
Activin A induces neuronal differentiation and survival via ALK4 in a SMAD-independent manner in a subpopulation of human neuroblastomas.
Topics: Activin Receptors, Type I; Activins; Adult; Cell Line, Tumor; Cell Nucleus; Cell Survival; Humans; Male; Neurogenesis; Neurons; Phosphorylation; Promoter Regions, Genetic; Smad Proteins; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transcriptional Activation; Transforming Growth Factor beta | 2010 |
The role of SMAD4 in human embryonic stem cell self-renewal and stem cell fate.
Topics: Activins; Cell Differentiation; Cell Division; Cell Lineage; Cells, Cultured; Down-Regulation; Embryonic Stem Cells; Humans; Nodal Protein; RNA Interference; Signal Transduction; Smad4 Protein; Transforming Growth Factor beta | 2010 |
Activin signaling functions upstream of Gbb to regulate synaptic growth at the Drosophila neuromuscular junction.
Topics: Activin Receptors; Activins; Animals; Carrier Proteins; Drosophila melanogaster; Drosophila Proteins; Neuromuscular Junction; Transforming Growth Factor beta | 2010 |
Expression of SMAD proteins, TGF-beta/activin signaling mediators, in human thyroid tissues.
Topics: Activins; Adenoma; Carcinoma, Papillary, Follicular; Goiter, Nodular; Humans; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Smad3 Protein; Smad4 Protein; Smad7 Protein; Thyroid Neoplasms; Transforming Growth Factor beta | 2010 |
Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; Butadienes; Cell Differentiation; Embryonic Stem Cells; Fibroblast Growth Factor 2; Humans; Mesoderm; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Protein Kinase Inhibitors; Signal Transduction; Transforming Growth Factor beta | 2010 |
Activin-related proteins in bovine mammary gland: localization and differential expression during gestational development and differentiation.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Cattle; Cell Differentiation; Female; Follistatin; Gene Expression; Gestational Age; Inhibin-beta Subunits; Inhibins; Mammary Glands, Animal; Pregnancy; Transforming Growth Factor beta | 2010 |
Activin A induces a non-fibrotic phenotype in smooth muscle cells in contrast to TGF-β.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Cells, Cultured; Endothelium, Vascular; Humans; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phenotype; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, Growth Factor; Recombinant Proteins; Saphenous Vein; Smad2 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2011 |
Lipid accumulation impairs adiponectin-mediated induction of activin A by increasing TGFbeta in primary human hepatocytes.
Topics: Activins; Adiponectin; Adult; Aged; Aged, 80 and over; Cell Line; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Hepatocytes; Humans; Male; Middle Aged; Oleic Acid; Palmitic Acid; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta | 2011 |
Altered gonadal expression of TGF-β superfamily signaling factors in environmental contaminant-exposed juvenile alligators.
Topics: Activins; Alligators and Crocodiles; Animals; Endocrine Disruptors; Environmental Exposure; Environmental Pollutants; Female; Follistatin; Gonads; Growth Differentiation Factor 9; Inhibins; Male; Ovum; Sex Determination Processes; Signal Transduction; Transforming Growth Factor beta | 2011 |
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
Topics: Activins; Body Patterning; Bone Morphogenetic Proteins; C-Peptide; Cell Line; Cell Lineage; Endoderm; Humans; Insulin; Insulin-Secreting Cells; Pancreas; Pluripotent Stem Cells; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins | 2011 |
Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles.
Topics: Activins; Animals; Bone Morphogenetic Protein 15; Claudins; Female; Growth Differentiation Factor 9; Ovarian Follicle; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions; Transforming Growth Factor beta; Zebrafish | 2011 |
InACTIVatINg cancer cachexia.
Topics: Activin Receptors, Type II; Activins; Animals; Cachexia; Disease Models, Animal; Humans; Mice; Muscle, Skeletal; Neoplasms; Signal Transduction; Transforming Growth Factor beta | 2011 |
Activation of the activin A-ALK-Smad pathway in systemic sclerosis.
Topics: Activin Receptors, Type I; Activins; Cells, Cultured; Collagen; Fibroblasts; Humans; Nitric Oxide; Scleroderma, Systemic; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2011 |
The Notch ligand Delta-like 1 integrates inputs from TGFbeta/Activin and Wnt pathways.
Topics: Activins; Apoptosis; Blotting, Western; Butyrates; Calcium-Binding Proteins; Cell Nucleus; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Colonic Neoplasms; Connective Tissue Growth Factor; Humans; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Luciferases; Membrane Proteins; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Tumor Cells, Cultured; Wnt Proteins | 2011 |
Differential response of cartilage oligomeric matrix protein (COMP) to morphogens of bone morphogenetic protein/transforming growth factor-β family in the surface, middle and deep zones of articular cartilage.
Topics: Activins; Animals; Bone Morphogenetic Protein 7; Cartilage, Articular; Cattle; Extracellular Matrix Proteins; Gene Expression Regulation; Glycoproteins; Growth Differentiation Factor 5; Immunohistochemistry; Matrilin Proteins; Protein Isoforms; RNA, Messenger; Time Factors; Transforming Growth Factor beta | 2011 |
Neuroendocrine regulation of Drosophila metamorphosis requires TGFbeta/Activin signaling.
Topics: Activins; Animals; Blotting, Western; Drosophila; Ecdysteroids; Endocrine Glands; Fluorescent Antibody Technique; In Situ Hybridization; Insect Hormones; Metamorphosis, Biological; Neurosecretory Systems; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transforming Growth Factor beta | 2011 |
TCam-2 seminoma cell line exhibits characteristic foetal germ cell responses to TGF-beta ligands and retinoic acid.
Topics: Activin Receptors, Type II; Activins; Adaptor Protein Complex 2; Biomarkers; Bone Morphogenetic Protein 4; Cell Line, Tumor; Cell Proliferation; Cell Survival; Germ Cells; Homeodomain Proteins; Humans; Ligands; Male; Nanog Homeobox Protein; Neoplasms, Germ Cell and Embryonal; Octamer Transcription Factor-3; Positive Regulatory Domain I-Binding Factor 1; Proto-Oncogene Proteins c-kit; Repressor Proteins; Seminoma; Signal Transduction; Testicular Neoplasms; Transforming Growth Factor beta; Tretinoin | 2011 |
Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process.
Topics: Activins; Animals; Apoptosis; Female; Fertility; Follicular Atresia; Follistatin; Granulosa Cells; Humans; Hyaluronoglucosaminidase; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oocytes; Ovarian Follicle; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta | 2012 |
TGFβ inhibition enhances the generation of hematopoietic progenitors from human ES cell-derived hemogenic endothelial cells using a stepwise strategy.
Topics: Activins; Animals; Benzamides; Cell Differentiation; Cell Line; Cell Proliferation; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factors; Flow Cytometry; Hemangioblasts; Hematopoietic Stem Cells; Humans; Leukosialin; Mesoderm; Mice; Signal Transduction; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A | 2012 |
ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN.
Topics: Activins; Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Nucleus; Genes, Reporter; Humans; Intracellular Signaling Peptides and Proteins; Luciferases, Renilla; Mice; Peptide Fragments; Protein Binding; Protein Interaction Domains and Motifs; Protein Transport; Response Elements; RNA Interference; Serine Endopeptidases; Smad2 Protein; Smad3 Protein; Transcriptional Activation; Transforming Growth Factor beta | 2011 |
TGF-β down under 2011-the experts interviewed!
Topics: Activins; Congresses as Topic; Follistatin; Humans; Inhibins; Neoplasms; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2011 |
Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.
Topics: Activins; Autocrine Communication; Blotting, Western; Bone Morphogenetic Proteins; Cell Line; Cell Movement; Cell Proliferation; Cell Shape; Female; Gene Expression; Humans; Inhibitor of Differentiation Protein 1; Molecular Sequence Data; Ovarian Neoplasms; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Smad Proteins; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 2011 |
Mesenchymal activin-A overcomes defective human trisomy 21 trophoblast fusion.
Topics: Activins; Cell Differentiation; Cell Fusion; Cells, Cultured; Cytokines; Down Syndrome; Female; Fetus; Humans; Mesoderm; Paracrine Communication; Placenta; Pregnancy; Transforming Growth Factor beta; Trophoblasts | 2011 |
Structural basis for specificity of TGFβ family receptor small molecule inhibitors.
Topics: Activin Receptors, Type I; Activins; Benzamides; Bone Morphogenetic Proteins; Crystallography, X-Ray; Dioxoles; Drug Design; HEK293 Cells; Humans; Inhibitory Concentration 50; Models, Molecular; Mutation; Phosphorylation; Plasmids; Protein Binding; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Serine; Signal Transduction; Substrate Specificity; Transfection; Transforming Growth Factor beta | 2012 |
The role of BMP2 signaling in the skeleton.
Topics: Activins; Animals; Bone and Bones; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein Receptors, Type II; Cell Differentiation; Fracture Healing; Gene Expression Regulation; Humans; Osteoblasts; Osteogenesis; Signal Transduction; Smad4 Protein; Transforming Growth Factor beta | 2011 |
TGF-β regulates sclerostin expression via the ECR5 enhancer.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line; Enhancer Elements, Genetic; Genetic Markers; Male; Mice; Osteoblasts; Parathyroid Hormone; Pteridines; Rats; Signal Transduction; Transforming Growth Factor beta | 2012 |
Cell-type specific regulation of myostatin signaling.
Topics: Activin Receptors; Activin Receptors, Type I; Activins; Animals; Cell Differentiation; Cell Line; Epidermal Growth Factor; Fibroblasts; Humans; Male; Membrane Glycoproteins; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Myoblasts; Myostatin; Neoplasm Proteins; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta | 2012 |
A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.
Topics: Activins; Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p15; Down-Regulation; Female; Genistein; Humans; Leiomyoma; Oligonucleotide Array Sequence Analysis; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Up-Regulation; Uterine Neoplasms | 2012 |
Bone morphogenetic protein (BMP) signaling regulates mitotic checkpoint protein levels in human breast cancer cells.
Topics: Activins; Benzamides; Bone Morphogenetic Proteins; Breast Neoplasms; Calcium-Binding Proteins; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; Cytoskeletal Proteins; Dioxoles; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Mad2 Proteins; Nocodazole; Nuclear Proteins; Plasmids; Poly-ADP-Ribose Binding Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Repressor Proteins; Signal Transduction; Transfection; Transforming Growth Factor beta | 2012 |
Activin A and TGF-β promote T(H)9 cell-mediated pulmonary allergic pathology.
Topics: Activins; Adoptive Transfer; Allergens; Animals; Cell Differentiation; Humans; Immunophenotyping; Lung; Lymphocyte Activation; Mast Cells; Mice; Mice, Inbred BALB C; Phenotype; Pyroglyphidae; Respiratory Hypersensitivity; T-Lymphocytes, Helper-Inducer; Transforming Growth Factor beta | 2012 |
Identification and expression of Smads associated with TGF-β/activin/nodal signaling pathways in the rainbow trout (Oncorhynchus mykiss).
Topics: Activins; Animals; Bone Morphogenetic Proteins; Brain; Embryo, Nonmammalian; Expressed Sequence Tags; Female; Follistatin; Gene Expression Regulation, Developmental; Gills; Growth Hormone; Heart; Kidney; Liver; Nodal Protein; Oncorhynchus mykiss; Phylogeny; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2012 |
Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status.
Topics: Activins; Adult; Aromatase; Blotting, Western; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line; Cell Proliferation; Cholesterol Side-Chain Cleavage Enzyme; Female; Follicle Stimulating Hormone; Gene Expression; Gonadotropins; Granulosa Cells; Humans; Phosphoproteins; Phosphorylation; Receptors, Gonadotropin; Reverse Transcriptase Polymerase Chain Reaction; Smad Proteins; Transforming Growth Factor beta | 2012 |
Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva.
Topics: Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Humans; Mutation; Myositis Ossificans; Ossification, Heterotopic; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2012 |
Confluence switch signaling regulates ECM composition and the plasmin proteolytic cascade in keratinocytes.
Topics: Activins; Adherens Junctions; Animals; Basement Membrane; Cell Adhesion; Cell Differentiation; Cell Movement; Cell Proliferation; Down-Regulation; Extracellular Matrix; Feedback, Physiological; Fibrinolysin; Heparan Sulfate Proteoglycans; Humans; Keratinocytes; Mice; Plasminogen; Plasminogen Activator Inhibitor 1; Protein Binding; Proteolysis; Proteomics; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Transforming Growth Factor beta; Urokinase-Type Plasminogen Activator; Wound Healing | 2012 |
Effects of activin and TGFβ on p21 in colon cancer.
Topics: Activins; Apoptosis; Colon; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Humans; Phosphorylation; Proteasome Endopeptidase Complex; Signal Transduction; Smad4 Protein; Transforming Growth Factor beta; Tumor Cells, Cultured; Ubiquitination | 2012 |
Reply: To PMID 22277204.
Topics: Activins; Animals; Humans; Respiratory Hypersensitivity; T-Lymphocytes, Helper-Inducer; Transforming Growth Factor beta | 2012 |
Inhibition of activin/nodal signalling is necessary for pancreatic differentiation of human pluripotent stem cells.
Topics: Activins; Animals; Cell Communication; Cell Differentiation; Female; Humans; Insulin-Secreting Cells; Male; Mice; Mice, SCID; Pancreas; Pluripotent Stem Cells; Regenerative Medicine; Signal Transduction; Transforming Growth Factor beta; Tretinoin | 2012 |
Synexpression group analyses identify new functions of FSTL3, a TGFβ ligand inhibitor.
Topics: Activins; Animals; Binding Sites; Data Mining; Follistatin-Related Proteins; Gene Expression Regulation; Ligands; Mice; Mice, Knockout; Organ Specificity; Promoter Regions, Genetic; Proteins; Smad Proteins; Transcription, Genetic; Transforming Growth Factor beta | 2012 |
The activin A antagonist follistatin inhibits asthmatic airway remodelling.
Topics: Activins; Administration, Intranasal; Airway Remodeling; Analysis of Variance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Follistatin; Immunohistochemistry; Interleukin-13; Interleukin-4; Interleukin-5; Mice; Mice, Inbred BALB C; Ovalbumin; Random Allocation; Reference Values; Sensitivity and Specificity; Transforming Growth Factor beta | 2013 |
Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.
Topics: Activins; Animals; Calcium; Cell Differentiation; Cells, Cultured; Dihydropyridines; Embryonic Stem Cells; Humans; Mice; Molecular Structure; Myocytes, Cardiac; Protein Binding; Protein Serine-Threonine Kinases; Quinolones; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta | 2012 |
R7 photoreceptor axon growth is temporally controlled by the transcription factor Ttk69, which inhibits growth in part by promoting transforming growth factor-β/activin signaling.
Topics: Activins; Animals; Animals, Genetically Modified; Axons; Drosophila; Drosophila Proteins; Photoreceptor Cells, Invertebrate; Repressor Proteins; Signal Transduction; Transforming Growth Factor beta | 2013 |
Activin and TGFβ regulate expression of the microRNA-181 family to promote cell migration and invasion in breast cancer cells.
Topics: Activins; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Neoplasm Invasiveness; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta | 2013 |
TGF-β superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury.
Topics: Activins; Animals; Brain Injuries; Cell Proliferation; Core Binding Factor Alpha 2 Subunit; Dentate Gyrus; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Intermediate Filament Proteins; Mice; Microglia; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Prosencephalon; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2013 |
Quantitative transcriptomics using designed primer-based amplification.
Topics: Activins; Animals; Cells, Cultured; DNA Primers; Embryonic Development; Embryonic Stem Cells; Mice; Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, RNA; Signal Transduction; Transcriptome; Transforming Growth Factor beta | 2013 |
α1,6-Fucosylation regulates neurite formation via the activin/phospho-Smad2 pathway in PC12 cells: the implicated dual effects of Fut8 for TGF-β/activin-mediated signaling.
Topics: Activins; Animals; Fucosyltransferases; Gene Expression Regulation; Gene Knockdown Techniques; Mice; Neurites; PC12 Cells; Rats; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta | 2013 |
Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential.
Topics: Activins; Animals; Biomarkers; Bone Morphogenetic Protein 4; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Endoderm; Fluorescent Antibody Technique; GATA6 Transcription Factor; Gene Expression Profiling; Germ Cells; Humans; Mice; Pluripotent Stem Cells; Signal Transduction; Transforming Growth Factor beta | 2013 |
Coco regulates dorsoventral specification of germ layers via inhibition of TGFβ signalling.
Topics: Activins; Animals; Blastula; Cell Communication; Ectoderm; Embryo, Nonmammalian; Endoderm; Germ Layers; Mesoderm; Nodal Protein; Signal Transduction; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2013 |
Characterization of the nutritional endoderm in the direct developing frog Eleutherodactylus coqui.
Topics: Activins; Amino Acid Sequence; Animals; Anura; Cloning, Molecular; Embryo, Nonmammalian; Embryonic Development; Endoderm; Intercellular Signaling Peptides and Proteins; Mesoderm; Molecular Sequence Data; Sequence Alignment; Transforming Growth Factor beta; Xenopus laevis | 2013 |
Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation.
Topics: Activins; Benzamides; Cell Line; Cell Proliferation; Dioxoles; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Stem Cells; Germ Layers; Homeodomain Proteins; Humans; Nanog Homeobox Protein; Transforming Growth Factor beta | 2014 |
miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.
Topics: Activins; Apoptosis; Cell Differentiation; Cell Line; Cell Lineage; Down-Regulation; Embryonic Stem Cells; GATA4 Transcription Factor; Gene Knockdown Techniques; HEK293 Cells; Humans; MicroRNAs; Signal Transduction; Transforming Growth Factor beta | 2014 |
GATA-2 inhibits transforming growth factor-β signaling pathway through interaction with Smad4.
Topics: Activins; Cell Differentiation; Cell Line; DNA; GATA2 Transcription Factor; HEK293 Cells; Hep G2 Cells; Histone Deacetylases; Humans; K562 Cells; Phosphorylation; Protein Binding; RNA Interference; RNA, Small Interfering; Signal Transduction; Smad2 Protein; Smad3 Protein; Smad4 Protein; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2014 |
TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
Topics: Activins; Animals; Antigens, CD; Antigens, Neoplasm; Bone Morphogenetic Protein 2; Cell Line, Tumor; Cytokines; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA Stability; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2014 |
An activin A/BMP2 chimera, AB204, displays bone-healing properties superior to those of BMP2.
Topics: Activin Receptors, Type I; Activins; Alkaline Phosphatase; Animals; Bone Morphogenetic Protein 2; Calcification, Physiologic; Cell Line; Humans; Mice; Osteogenesis; Point Mutation; Recombinant Fusion Proteins; Recombinant Proteins; Skull; Tibia; Transforming Growth Factor beta; Wound Healing | 2014 |
The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling.
Topics: Activins; Blotting, Western; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Endoderm; Flow Cytometry; Glycogen Synthase Kinase 3; Humans; Immunoenzyme Techniques; Mesoderm; Pancreas; Pyridines; Pyrimidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Wnt Proteins | 2014 |
Derivation of mesenchymal stromal cells from canine induced pluripotent stem cells by inhibition of the TGFβ/activin signaling pathway.
Topics: Activins; Animals; Antigens, CD; Cells, Cultured; Chemokine CXCL12; Chondrogenesis; Dogs; Guanine Nucleotide Exchange Factors; Histones; Induced Pluripotent Stem Cells; Mesenchymal Stem Cells; Octamer Transcription Factor-3; Osteogenesis; Pentosan Sulfuric Polyester; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Transforming Growth Factor beta; Vascular Endothelial Growth Factor Receptor-2 | 2014 |
Divergence(s) in nodal signaling between aggressive melanoma and embryonic stem cells.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Blotting, Western; Cells, Cultured; Embryonic Stem Cells; Humans; Melanoma; Nodal Protein; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Skin Neoplasms; Transforming Growth Factor beta | 2015 |
TGFβ and Wnt in cardiac outflow tract defects in offspring of diabetic pregnancies.
Topics: Activins; Animals; Aorta; Aortic Valve Stenosis; Cardiac Output; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes, Gestational; Embryo Culture Techniques; Embryo, Mammalian; Endocardial Cushions; Endoplasmic Reticulum Stress; Female; Gene Expression Regulation, Developmental; Glucose; Heart Defects, Congenital; Hyperglycemia; Mice; Mice, Inbred C57BL; Neural Crest; Oxidative Stress; Pregnancy; Pulmonary Artery; Pulmonary Valve Stenosis; Smad3 Protein; Streptozocin; Transforming Growth Factor beta; Truncus Arteriosus, Persistent; Wnt Proteins; Wnt Signaling Pathway | 2014 |
Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.
Topics: Activins; Animals; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Ligands; Mutation; Neuromuscular Junction; Protein Transport; Receptors, Glutamate; Signal Transduction; Smad Proteins, Receptor-Regulated; Synaptic Potentials; Transcription Factors; Transforming Growth Factor beta; Tumor Suppressor Proteins | 2014 |
Transforming growth factor β/activin signaling functions as a sugar-sensing feedback loop to regulate digestive enzyme expression.
Topics: Activins; Animals; Drosophila; Glucose; Glycoside Hydrolases; Lipoprotein Lipase; Signal Transduction; Transforming Growth Factor beta | 2014 |
hARIP2 is a putative growth-promoting factor involved in human colon tumorigenesis.
Topics: Activins; Apoptosis; Blotting, Western; Carcinogenesis; Cell Proliferation; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Phosphorylation; Real-Time Polymerase Chain Reaction; Receptor-Interacting Protein Serine-Threonine Kinase 2; RNA, Neoplasm; Transfection; Transforming Growth Factor beta; Tumor Cells, Cultured | 2014 |
Development of novel activin-targeted therapeutics.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Dependovirus; Gene Expression Regulation; Genetic Engineering; Genetic Vectors; Growth Differentiation Factors; HEK293 Cells; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myostatin; Plasmids; Protein Structure, Tertiary; Recombinant Fusion Proteins; Signal Transduction; Transfection; Transforming Growth Factor beta | 2015 |
The Lophotrochozoan TGF-β signalling cassette - diversification and conservation in a key signalling pathway.
Topics: Activins; Animals; Annelida; Body Patterning; Bone Morphogenetic Proteins; Evolution, Molecular; Gene Expression Regulation, Developmental; Mollusca; Nodal Protein; Rotifera; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2014 |
Effects of activin A on survival, function and gene expression of pancreatic islets from non-diabetic and diabetic human donors.
Topics: Activins; Adult; Aged; Cell Survival; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Flow Cytometry; Gene Expression; Glucagon-Secreting Cells; Humans; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Real-Time Polymerase Chain Reaction; Transforming Growth Factor beta; Young Adult | 2014 |
PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
Topics: Activins; Cell Differentiation; Cell Line, Tumor; Embryonic Stem Cells; Endoderm; HEK293 Cells; Humans; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Phosphorylation; Receptor Cross-Talk; Smad Proteins, Receptor-Regulated; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2015 |
Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos.
Topics: Activins; Animals; Binding Sites; Blastula; Bone Morphogenetic Proteins; Female; Gastrula; Gene Knockdown Techniques; Germ Layers; Ligands; Nodal Signaling Ligands; Phosphoprotein Phosphatases; Phosphorylation; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Smad Proteins, Receptor-Regulated; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2015 |
Tumor inoculation site affects the development of cancer cachexia and muscle wasting.
Topics: Activins; Animals; Cachexia; Cell Line, Tumor; Disease Models, Animal; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myocardium; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Transforming Growth Factor beta; Tripartite Motif Proteins; Tumor Microenvironment; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases | 2015 |
Differential Expression and Release of Activin A and Follistatin in Chronic Rhinosinusitis with and without Nasal Polyps.
Topics: Activins; Adolescent; Adult; Aged; Aged, 80 and over; Chronic Disease; Extracellular Matrix Proteins; Female; Follistatin; Humans; Inflammation; Interferon-gamma; Interleukin-5; Male; Middle Aged; Nasal Polyps; Sinusitis; Transforming Growth Factor beta; Young Adult | 2015 |
Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway.
Topics: Activins; Carcinoma; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Radiotherapy; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2016 |
Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells.
Topics: Activins; Animals; Cell Differentiation; Ectoderm; Embryo, Mammalian; Endoderm; Feedback, Physiological; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histone Deacetylase 2; Homeodomain Proteins; Mesoderm; Mice; Mouse Embryonic Stem Cells; Nanog Homeobox Protein; Octamer Transcription Factor-3; Pluripotent Stem Cells; Repressor Proteins; Signal Transduction; SOXB1 Transcription Factors; Transforming Growth Factor beta | 2015 |
Cooperative Effects of FOXL2 with the Members of TGF-β Superfamily on FSH Receptor mRNA Expression and Granulosa Cell Proliferation from Hen Prehierarchical Follicles.
Topics: Activins; Animals; Autocrine Communication; Avian Proteins; Cell Proliferation; Chickens; Cholesterol Side-Chain Cleavage Enzyme; Cyclin D2; Female; Follistatin; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Granulosa Cells; Growth Differentiation Factor 9; Phosphoproteins; Receptors, FSH; RNA, Messenger; Signal Transduction; Smad Proteins; Transcription, Genetic; Transforming Growth Factor beta | 2015 |
Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.
Topics: Activin Receptors, Type I; Activins; Bone Morphogenetic Proteins; Calcification, Physiologic; Chondrogenesis; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myositis Ossificans; Signal Transduction; Transforming Growth Factor beta | 2015 |
Signaling and Gene Regulatory Networks Governing Definitive Endoderm Derivation From Pluripotent Stem Cells.
Topics: Activins; Cell Differentiation; Cell Lineage; Endoderm; Gene Regulatory Networks; Human Embryonic Stem Cells; Humans; Pancreas; Pluripotent Stem Cells; Signal Transduction; Transforming Growth Factor beta | 2016 |
The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFβ and β1 integrin signalling.
Topics: Activins; Carcinoma; Cell Adhesion; Cell Line; Epithelial Cells; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Integrin beta1; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Oncogene Proteins; Signal Transduction; Transforming Growth Factor beta; Viral Matrix Proteins | 2016 |
New Ligand Binding Function of Human Cerberus and Role of Proteolytic Processing in Regulating Ligand-Receptor Interactions and Antagonist Activity.
Topics: Activins; Amino Acid Sequence; Animals; Bone Morphogenetic Proteins; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cytokines; Female; Humans; Molecular Sequence Data; Proteolysis; Sequence Alignment; Signal Transduction; Transforming Growth Factor beta | 2016 |
Uric acid: a modulator of prostate cells and activin sensitivity.
Topics: Activins; Cell Line, Tumor; Glucose Transport Proteins, Facilitative; Humans; Male; Probenecid; Prostate; Prostatic Neoplasms; RNA, Messenger; Tissue Array Analysis; Transforming Growth Factor beta; Uric Acid | 2016 |
Effects of c-Jun N-terminal kinase on Activin A/Smads signaling in PC12 cell suffered from oxygen-glucose deprivation.
Topics: Activins; Animals; Anthracenes; Blotting, Western; Cell Differentiation; Cell Hypoxia; Cell Survival; Epithelial-Mesenchymal Transition; Glucose; JNK Mitogen-Activated Protein Kinases; Microscopy, Fluorescence; Nerve Growth Factor; Oxygen; PC12 Cells; Phosphorylation; Rats; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2016 |
Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding.
Topics: Activin Receptors, Type II; Activins; Binding, Competitive; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Line, Tumor; Follistatin; Growth Differentiation Factor 2; Growth Differentiation Factors; Hep G2 Cells; Humans; Ligands; Recombinant Proteins; Signal Transduction; Transforming Growth Factor beta | 2016 |
Activin A regulates microRNAs and gene expression in LNCaP cells.
Topics: Activins; Cell Cycle; Cell Line, Tumor; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Ki-67 Antigen; Male; MicroRNAs; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Transforming Growth Factor beta | 2016 |
Regulation of fibrillins and modulators of TGFβ in fetal bovine and human ovaries.
Topics: Activins; Animals; Cattle; Cells, Cultured; Female; Fetus; Fibrillin-1; Fibrillin-2; Fibrillins; Fibroblasts; Gene Expression Regulation; Humans; Ovary; Pregnancy; Transforming Growth Factor beta | 2016 |
Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling.
Topics: Activins; beta Catenin; Body Patterning; Bone Morphogenetic Protein 4; Cell Differentiation; Cell Line; Endoderm; Fibroblast Growth Factor 2; Gene Expression Regulation, Developmental; Hepatocyte Nuclear Factor 3-beta; Homeodomain Proteins; Human Embryonic Stem Cells; Humans; Immunomagnetic Separation; Mesoderm; SOXB1 Transcription Factors; Trans-Activators; Transforming Growth Factor beta; Tretinoin; Wnt Signaling Pathway; Wnt3 Protein | 2016 |
Smads and insect hemimetabolan metamorphosis.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cockroaches; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Juvenile Hormones; Kruppel-Like Transcription Factors; Metamorphosis, Biological; Molting; RNA Interference; RNA, Small Interfering; Signal Transduction; Smad Proteins; Smad Proteins, Receptor-Regulated; Smad4 Protein; Transcription Factors; Transforming Growth Factor beta | 2016 |
Endogenous inhibins regulate steroidogenesis in mouse TM3 Leydig cells by altering SMAD2 signalling.
Topics: Activins; Animals; Cell Line; Down-Regulation; Gene Knockdown Techniques; Humans; Inhibins; Leydig Cells; Male; Mice, Inbred C57BL; Protein Subunits; Signal Transduction; Smad2 Protein; Steroid 17-alpha-Hydroxylase; Steroids; Transforming Growth Factor beta | 2016 |
TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster.
Topics: Activins; Animals; Animals, Genetically Modified; Bone Morphogenetic Proteins; Carrier Proteins; Cells, Cultured; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Host-Parasite Interactions; Immunity, Innate; Nematoda; Nematode Infections; Photorhabdus; Signal Transduction; Transcriptional Activation; Transforming Growth Factor beta | 2016 |
Activin A-induced increase in LOX activity in human granulosa-lutein cells is mediated by CTGF.
Topics: Activins; Cells, Cultured; Connective Tissue Growth Factor; Female; Gene Expression Regulation, Enzymologic; Granulosa Cells; Humans; Luteal Cells; Ovarian Follicle; Protein-Lysine 6-Oxidase; Transforming Growth Factor beta | 2016 |
Seminal plasma transforming growth factor-β, activin A and follistatin fluctuate within men over time.
Topics: Activins; Adolescent; Adult; Age Factors; Aging; Follistatin; Humans; Male; Middle Aged; Semen; Semen Analysis; Sperm Count; Transforming Growth Factor beta; Young Adult | 2016 |
TGFβ Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice.
Topics: Activin Receptors, Type II; Activins; Animals; Bone Morphogenetic Proteins; Castration; Growth Differentiation Factors; Male; Mice; Mice, Inbred C57BL; Muscle Strength; Myostatin; Obesity; Sarcopenia; Transforming Growth Factor beta | 2016 |
Activin inhibition limits early innate immune response in rat kidney allografts-a pilot study.
Topics: Activins; Allografts; Animals; Cytokines; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; Immunity, Innate; Inflammation; Kidney; Kidney Transplantation; Male; Pilot Projects; Rats; Rats, Wistar; Renal Insufficiency; Reperfusion Injury; Signal Transduction; Time Factors; Transforming Growth Factor beta; Transplantation, Homologous | 2017 |
Smad2 Phosphorylation in Diabetic Kidney Tubule Epithelial Cells Is Associated with Modulation of Several Transforming Growth Factor-β Family Members.
Topics: Activins; Adult; Aged; Aged, 80 and over; Animals; Bone Morphogenetic Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Epithelial Cells; Female; Humans; Kidney Tubules; Male; Mice; Mice, 129 Strain; Middle Aged; Models, Biological; Phosphorylation; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta; Up-Regulation | 2017 |
Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells.
Topics: Activins; Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Germ Layers; HEK293 Cells; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mouse Embryonic Stem Cells; Pluripotent Stem Cells; Transcription Factors; Transforming Growth Factor beta; Wnt Signaling Pathway | 2017 |
TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands.
Topics: Activin Receptors, Type II; Activins; Animals; Cell Cycle; Cell Nucleolus; Cell Proliferation; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Ribosomes; Salivary Glands; Signal Transduction; Smad Proteins, Receptor-Regulated; Smad2 Protein; Transforming Growth Factor beta | 2017 |
Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2.
Topics: Activins; Animals; Antibodies, Neutralizing; Biomarkers; Cilia; Epithelial Cells; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Humans; Kidney; Kidney Tubules, Proximal; Ligands; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Protein Serine-Threonine Kinases; Rats; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Rheology; Shear Strength; Signal Transduction; Smad Proteins; Stress, Mechanical; Time Factors; Transforming Growth Factor beta | 2017 |
The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways.
Topics: Activins; Animals; DNA Mutational Analysis; Follicle Stimulating Hormone, beta Subunit; Follow-Up Studies; Gene Deletion; Humans; Hypothyroidism; Immunoglobulins; Infant, Newborn; Male; Membrane Proteins; Mice; Pituitary Gland; Promoter Regions, Genetic; Rats; Rats, Wistar; Receptors, Thyrotropin-Releasing Hormone; Smad Proteins; Testis; Transforming Growth Factor beta | 2017 |
Maternal circulating levels of transforming growth factor-β superfamily and its soluble receptors in hypertensive disorders of pregnancy.
Topics: Activins; Adult; Endoglin; Female; Humans; Hypertension, Pregnancy-Induced; Inhibins; Pre-Eclampsia; Pregnancy; Proteoglycans; Receptors, Transforming Growth Factor beta; Retrospective Studies; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2017 |
The careg element reveals a common regulation of regeneration in the zebrafish myocardium and fin.
Topics: Activins; Animal Fins; Animals; Connective Tissue Growth Factor; Female; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Heart; Inhibins; Male; Myocardium; Myocytes, Cardiac; Regeneration; Transforming Growth Factor beta; Wound Healing; Zebrafish; Zebrafish Proteins | 2017 |
The effects of activin A on the migration of human breast cancer cells and neutrophils and their migratory interaction.
Topics: Activins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Humans; Inflammation; Neutrophils; Transforming Growth Factor beta | 2017 |
Comparison of the osteogenesis and fusion rates between activin A/BMP-2 chimera (AB204) and rhBMP-2 in a beagle's posterolateral lumbar spine model.
Topics: Activins; Animals; Bone Morphogenetic Protein 2; Dogs; Hydroxyapatites; Lumbar Vertebrae; Male; Models, Animal; Osteogenesis; Recombinant Fusion Proteins; Recombinant Proteins; Spinal Fusion; Tomography, X-Ray Computed; Transforming Growth Factor beta | 2017 |
Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease.
Topics: Activins; Animals; Dependovirus; Gene Targeting; Genetic Vectors; Male; Mice; Muscle Proteins; Muscle, Skeletal; Muscular Diseases; Organ Size; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2017 |
Optimizing bone morphogenic protein 4-mediated human embryonic stem cell differentiation into trophoblast-like cells using fibroblast growth factor 2 and transforming growth factor-β/activin/nodal signalling inhibition.
Topics: Activins; Bone Morphogenetic Protein 4; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Down-Regulation; Fibroblast Growth Factor 2; Human Embryonic Stem Cells; Humans; Nodal Protein; Signal Transduction; Transforming Growth Factor beta; Trophoblasts | 2017 |
Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer.
Topics: Activins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Neoplasm Staging; Prognosis; Signal Transduction; Survival Analysis; Transforming Growth Factor beta; Up-Regulation | 2017 |
Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.
Topics: Activins; Animals; Cell Differentiation; Chondrocytes; Chondrogenesis; Embryonic Stem Cells; Female; Humans; Induced Pluripotent Stem Cells; Inhibitory Concentration 50; Lysophospholipids; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Myositis Ossificans; Oligonucleotide Array Sequence Analysis; Phosphoric Diester Hydrolases; Point Mutation; Recombinant Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta | 2017 |
Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin.
Topics: Activins; Animals; Biomarkers; Cannabinoid Receptor Antagonists; Cytoprotection; Disease Models, Animal; Follistatin; Gene Expression Regulation; Liver; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Transforming Growth Factor beta | 2017 |
Transforming Growth Factor β/Activin signaling in neurons increases susceptibility to starvation.
Topics: Activins; Animals; Drosophila; Glycogen; Neurons; Signal Transduction; Starvation; Transforming Growth Factor beta; Triglycerides | 2017 |
Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells.
Topics: Activins; Aged; Animals; Case-Control Studies; Fibrosis; Hepatic Stellate Cells; Humans; Kupffer Cells; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred BALB C; Middle Aged; Non-alcoholic Fatty Liver Disease; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2018 |
Molecular characterization of latent GDF8 reveals mechanisms of activation.
Topics: Activins; Animals; Atrophy; Cell Differentiation; Dependovirus; Growth Differentiation Factor 2; Growth Differentiation Factors; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Ligands; Male; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Myostatin; Protein Domains; Scattering, Small Angle; Signal Transduction; Transforming Growth Factor beta | 2018 |
Autocrine transforming growth factor-β/activin A-Smad signaling induces hepatic progenitor cells undergoing partial epithelial-mesenchymal transition states.
Topics: Activin Receptors, Type I; Activins; Autocrine Communication; Epithelial-Mesenchymal Transition; Hepatocytes; Humans; Intracellular Space; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Stem Cells; Transforming Growth Factor beta | 2018 |
Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.
Topics: Activin Receptors; Activins; Anemia, Diamond-Blackfan; Animals; Arginine; Benzamides; Benzhydryl Compounds; Complement C3a; Dioxoles; Disease Models, Animal; Humans; Immunity, Innate; Interferons; K562 Cells; Receptor, Transforming Growth Factor-beta Type I; Ribosomal Proteins; RNA, Small Interfering; Toll-Like Receptor 3; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Up-Regulation; Zebrafish; Zebrafish Proteins | 2018 |
miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-β signaling pathway.
Topics: Activins; Animals; Cadherins; Cell Line; Cell Line, Tumor; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Male; Matrix Metalloproteinase 2; Mice; MicroRNAs; Neoplasm Invasiveness; NIH 3T3 Cells; Prostatic Neoplasms; Signal Transduction; Smad3 Protein; Snail Family Transcription Factors; Transforming Growth Factor beta; Twist-Related Protein 1 | 2018 |
Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension.
Topics: Activins; Adult; Antibodies; Cell Proliferation; Culture Media, Conditioned; Female; Humans; Hypertension, Pulmonary; Intercellular Signaling Peptides and Proteins; Male; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pulmonary Artery; Signal Transduction; Smad2 Protein; Smad3 Protein; Solubility; Transforming Growth Factor beta; Up-Regulation; Young Adult | 2018 |
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids.
Topics: Activins; Animals; Base Sequence; Bone Morphogenetic Proteins; Cell Differentiation; Endoderm; Gastrulation; Genes, Reporter; Humans; Mesoderm; Mice; Nucleotide Motifs; Pluripotent Stem Cells; Rats; Smad Proteins; Transcription, Genetic; Transforming Growth Factor beta; Wnt Signaling Pathway | 2018 |
Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine.
Topics: Activin Receptors, Type I; Activins; Adipocytes, Beige; Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Body Weight; Cell Differentiation; Cold Temperature; Energy Metabolism; Fibroblast Growth Factors; Glucose; HEK293 Cells; Homeostasis; Humans; Inhibin-beta Subunits; Insulin Resistance; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; Mice, Knockout; Thermogenesis; Transforming Growth Factor beta | 2018 |
The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line; Down-Regulation; Endosomal Sorting Complexes Required for Transport; Epithelial-Mesenchymal Transition; Genome, Human; Humans; Lysosomes; Mice; Multivesicular Bodies; Neoplasms; Phosphorylation; Prognosis; Protein Transport; Proteolysis; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad2 Protein; Survival Analysis; Transforming Growth Factor beta; Ubiquitin-Protein Ligases; Up-Regulation | 2018 |
Impaired Glucocorticoid Suppression of TGFβ Signaling in Human Omental Adipose Tissues Limits Adipogenesis and May Promote Fibrosis.
Topics: Activins; Adipogenesis; Adipose Tissue; Adult; Dexamethasone; Diabetes Mellitus, Type 2; Female; Fibrosis; Glucocorticoids; Humans; Interleukin-6; Male; Middle Aged; Omentum; Proteoglycans; Receptors, Transforming Growth Factor beta; Stem Cells; Transforming Growth Factor beta; Young Adult | 2019 |
Identification and expression of the medaka inhibin βE subunit.
Topics: Activins; Amino Acid Sequence; Animals; DNA, Complementary; Inhibin-beta Subunits; Inhibins; Liver; Oryzias; RNA, Messenger; Transforming Growth Factor beta | 2019 |
Synergy with TGFβ ligands switches WNT pathway dynamics from transient to sustained during human pluripotent cell differentiation.
Topics: Activins; Adaptation, Biological; beta Catenin; Bone Morphogenetic Protein 4; Cell Differentiation; CRISPR-Cas Systems; Glycogen Synthase Kinase 3 beta; Green Fluorescent Proteins; Human Embryonic Stem Cells; Humans; Ligands; Pluripotent Stem Cells; Protein Stability; Transforming Growth Factor beta; Wnt Proteins; Wnt Signaling Pathway | 2019 |
ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis.
Topics: Activin Receptors, Type I; Activins; Animals; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Transformation, Neoplastic; Female; Heterografts; Homeostasis; Humans; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mice, SCID; Neoplasm Metastasis; Neoplasms; Pancreatic Neoplasms; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Tumor Microenvironment | 2019 |
TGF-β family ligands exhibit distinct signalling dynamics that are driven by receptor localisation.
Topics: Activins; Animals; Bone Morphogenetic Protein 4; Cell Line, Tumor; Cell Membrane; Humans; Ligands; Mice; Models, Biological; NIH 3T3 Cells; Protein Biosynthesis; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2019 |
Quantitative Differences in TGF-β Family Members Measured in Small Antral Follicle Fluids From Women With or Without PCO.
Topics: Activins; Adolescent; Adult; Anti-Mullerian Hormone; Biomarkers; Case-Control Studies; Female; Follicular Fluid; Follistatin; Follow-Up Studies; Gene Expression Regulation; Growth Differentiation Factor 9; Humans; Inhibins; Ovarian Follicle; Ovary; Polycystic Ovary Syndrome; Prognosis; Transforming Growth Factor beta; Young Adult | 2019 |
VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation.
Topics: Activins; Animals; Embryonic Development; Embryonic Stem Cells; Gene Knockdown Techniques; HaCaT Cells; HEK293 Cells; Hep G2 Cells; Humans; Mesoderm; Mice; Protein Serine-Threonine Kinases; Proteolysis; Receptor, Transforming Growth Factor-beta Type I; Smad7 Protein; Transfection; Transforming Growth Factor beta; Ubiquitin-Protein Ligases; Ubiquitination; Zebrafish | 2020 |
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Humans; Mice; Models, Molecular; Multiprotein Complexes; Rats; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta | 2019 |
Interplay between Lefty and Nodal signaling is essential for the organizer and axial formation in amphioxus embryos.
Topics: Activins; Animals; Body Patterning; Female; Gastrula; Gene Expression Regulation, Developmental; Homeodomain Proteins; Lancelets; Left-Right Determination Factors; Male; Nodal Protein; Signal Transduction; Transforming Growth Factor beta | 2019 |
Single-cell qPCR demonstrates that Repsox treatment changes cell fate from endoderm to neuroectoderm and disrupts epithelial-mesenchymal transition.
Topics: Activins; Cell Lineage; Endoderm; Epithelial-Mesenchymal Transition; Humans; Neural Plate; Polymerase Chain Reaction; Primitive Streak; Pyrazoles; Pyridines; Signal Transduction; Single-Cell Analysis; Transforming Growth Factor beta | 2019 |
Discovery of a follistatin-derived myostatin inhibitory peptide.
Topics: Activins; Amino Acid Sequence; Animals; Binding Sites; Follistatin; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myostatin; Peptides; Protein Binding; Structure-Activity Relationship; Transforming Growth Factor beta | 2020 |
Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling.
Topics: Activins; Aged; Aged, 80 and over; Cadherins; Cancer-Associated Fibroblasts; Case-Control Studies; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Signal Transduction; Snail Family Transcription Factors; Transforming Growth Factor beta; Tumor Microenvironment | 2020 |
Visualization of Endogenous Type I TGF-β Receptor Baboon in the Drosophila Brain.
Topics: Activin Receptors; Activins; Animals; Animals, Genetically Modified; Axons; Brain; Carrier Proteins; Drosophila; Drosophila Proteins; Gene Expression Regulation, Developmental; Gene Knock-In Techniques; Hemagglutinin Glycoproteins, Influenza Virus; MicroRNAs; Mushroom Bodies; Neurites; Signal Transduction; Transforming Growth Factor beta | 2020 |
Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors.
Topics: Activin Receptors, Type I; Activins; Bone Morphogenetic Protein Receptors, Type I; Cell Line, Tumor; Humans; Protein Multimerization; Protein Structure, Quaternary; Smad Proteins; Substrate Specificity; Transforming Growth Factor beta | 2020 |
MicroRNA‑431 inhibits the expression of surfactant proteins through the BMP4/activin/TGF‑β signaling pathway by targeting SMAD4.
Topics: A549 Cells; Activins; Bone Morphogenetic Protein 4; Cell Line, Tumor; Down-Regulation; Gene Expression Regulation; Humans; Lung; MicroRNAs; Pulmonary Surfactant-Associated Proteins; RNA, Messenger; Signal Transduction; Smad4 Protein; Transforming Growth Factor beta | 2020 |
Tbx2 mediates dorsal patterning and germ layer suppression through inhibition of BMP/GDF and Activin/Nodal signaling.
Topics: Activins; Animals; Body Patterning; Bone Morphogenetic Proteins; Ectoderm; Gene Expression Regulation, Developmental; Germ Layers; Growth Differentiation Factors; Phosphorylation; Protein Domains; Signal Transduction; Smad1 Protein; Smad2 Protein; T-Box Domain Proteins; Transforming Growth Factor beta; Xenopus laevis; Xenopus Proteins | 2020 |
Evidence that activin A directly modulates early human male germline differentiation status.
Topics: Activins; Cell Differentiation; Gene Expression Profiling; Gene Expression Regulation; Germ Cells; Humans; Male; Nodal Protein; Seminoma; Testicular Neoplasms; Transforming Growth Factor beta | 2020 |
Computational modeling of transforming growth factor β and activin a receptor complex formation in the context of promiscuous signaling regulation.
Topics: Activin Receptors, Type I; Activins; Molecular Docking Simulation; Pyrazoles; Quinolines; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta | 2021 |
Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity.
Topics: Activins; Animals; Drosophila melanogaster; Drosophila Proteins; Ligands; Mushroom Bodies; Neural Stem Cells; Neurons; RNA-Binding Proteins; Signal Transduction; Transforming Growth Factor beta | 2020 |
Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line; Gene Expression Regulation; HEK293 Cells; Hep G2 Cells; Humans; Mice; Ossification, Heterotopic; Phosphorylation; Signal Transduction; Transforming Growth Factor beta | 2020 |
Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence.
Topics: Activins; Animals; Cocaine; Cocaine-Related Disorders; Drug-Seeking Behavior; Extinction, Psychological; Hippocampus; Inhibin-beta Subunits; Male; Neuronal Plasticity; Phosphorylation; Rats; Rats, Sprague-Dawley; Recurrence; Self Administration; Transforming Growth Factor beta | 2020 |
Activin A Promotes Regulatory T-cell-Mediated Immunosuppression in Irradiated Breast Cancer.
Topics: Activins; Animals; Breast Neoplasms; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Female; Humans; Immunosuppression Therapy; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tumor Microenvironment | 2021 |
The TGF-β superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation.
Topics: Activin Receptors, Type I; Activins; Animals; Cell Differentiation; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental; Humans; Mice; Mice, Knockout; Molecular Targeted Therapy; Multiple Sclerosis; Neurogenic Inflammation; Signal Transduction; Th17 Cells; Transforming Growth Factor beta | 2021 |
Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family.
Topics: Activins; Amino Acid Sequence; Anti-Mullerian Hormone; Bone Morphogenetic Proteins; Crystallography, X-Ray; Models, Molecular; Receptors, Peptide; Receptors, Transforming Growth Factor beta; Signal Transduction; Structural Homology, Protein; Transforming Growth Factor beta | 2021 |
Downregulation of CRX, a Group 3-specific oncogenic transcription factor, inhibits TGF-β/activin signaling in medulloblastoma cells.
Topics: Activins; Animals; Cell Line, Tumor; Cerebellar Neoplasms; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Male; Medulloblastoma; Mice, Inbred NOD; Mice, SCID; Signal Transduction; Trans-Activators; Transforming Growth Factor beta | 2021 |
Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects.
Topics: Activins; Animals; Cell Line; Cell Lineage; Cell Polarity; Cells, Cultured; Epithelial Cells; Germ Layers; Human Embryonic Stem Cells; Humans; Huntingtin Protein; Mice; Signal Transduction; Transforming Growth Factor beta; Trinucleotide Repeat Expansion | 2021 |
Differential impact of TGFβ/SMAD signaling activity elicited by Activin A and Nodal on endoderm differentiation of epiblast stem cells.
Topics: Activins; Cell Differentiation; Endoderm; Germ Layers; Nodal Protein; Stem Cells; Transforming Growth Factor beta | 2022 |
Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways.
Topics: Activins; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Ligands; Smad Proteins; Transforming Growth Factor beta | 2022 |
Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence.
Topics: Activins; Animals; Male; Mice; Prostate; Signal Transduction; Transforming Growth Factor beta | 2022 |
A network of transcription factors governs the dynamics of NODAL/Activin transcriptional responses.
Topics: Activins; Chromatin; Gene Expression Regulation, Developmental; Humans; Membrane Proteins; Nodal Protein; Smad2 Protein; Transcription Factors; Transforming Growth Factor beta | 2022 |
Identification, expression and functional analysis of activin type I receptor in common Chinese Cuttlefish, Sepiella japonica.
Topics: Activin Receptors; Activins; Animals; China; Decapodiformes; DNA, Complementary; Female; HEK293 Cells; Humans; Transforming Growth Factor beta; Vitellogenins | 2022 |
Activin-A, Growth Differentiation Factor-11 and Transforming Growth Factor-β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer.
Topics: Activins; Adult; Biomarkers; Bone Morphogenetic Proteins; Carcinoma, Non-Small-Cell Lung; Growth Differentiation Factors; Humans; Lung Neoplasms; Organoplatinum Compounds; Platinum; Prospective Studies; Retrospective Studies; Transforming Growth Factor beta; Transforming Growth Factors | 2022 |
Coordinated activation of TGF-β and BMP pathways promotes autophagy and limits liver injury after acetaminophen intoxication.
Topics: Acetaminophen; Activins; Animals; Autophagy; Bone Morphogenetic Proteins; Chemical and Drug Induced Liver Injury; Liver; Mice; Signal Transduction; Transforming Growth Factor beta | 2022 |
HMCES modulates the transcriptional regulation of nodal/activin and BMP signaling in mESCs.
Topics: Activins; Bone Morphogenetic Proteins; Chromatin; Gene Expression Regulation, Developmental; Mouse Embryonic Stem Cells; Smad Proteins, Receptor-Regulated; Transforming Growth Factor beta; Xenopus Proteins | 2022 |
Activin B promotes the initiation and progression of liver fibrosis.
Topics: Activins; Adenosine Diphosphate; Animals; Carbon Tetrachloride; Humans; Liver Cirrhosis; Mice; Nitric Oxide Synthase Type II; Ribose; Transforming Growth Factor beta | 2022 |
Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs.
Topics: Activin Receptors, Type I; Activins; Animals; Doxycycline; Humans; Inflammation; Lipopolysaccharides; Mice; Monocytes; Mutation; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction; Transforming Growth Factor beta | 2022 |
LncRNA-Smad7 mediates cross-talk between Nodal/TGF-β and BMP signaling to regulate cell fate determination of pluripotent and multipotent cells.
Topics: Activins; Animals; Cell Differentiation; Ligands; Mice; RNA, Long Noncoding; Smad7 Protein; Transforming Growth Factor beta | 2022 |
The TGF-β Receptor Gene
Topics: Activins; Animals; Ecdysterone; Insect Proteins; Larva; Protein Isoforms; Pupa; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA Interference; Transforming Growth Factor beta; Transforming Growth Factors; Tribolium | 2022 |
Detection of activin receptor type IIA and IIB-Fc fusion proteins by automated capillary immunoassay.
Topics: Activin Receptors, Type II; Activins; Erythropoiesis; Humans; Immunoassay; Immunoglobulin Fc Fragments; Recombinant Fusion Proteins; Transforming Growth Factor beta | 2022 |
Transcriptional Profiling of TGF-β Superfamily Members in Lumbar DRGs of Rats Following Sciatic Nerve Axotomy and Activin C Inhibits Neuropathic Pain.
Topics: Activins; Animals; Axotomy; Inhibins; Male; Neuralgia; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sciatic Nerve; Transforming Growth Factor beta; Transforming Growth Factors | 2023 |
Hepatic Activin A: An Exciting Target for Cardiometabolic Health.
Topics: Activins; Cardiovascular Diseases; Humans; Liver; Transforming Growth Factor beta | 2023 |
Activin A Modulates Betaglycan Shedding via the ALK4-SMAD3-Dependent Pathway in Endometriotic Cells.
Topics: Activin Receptors, Type I; Activins; Endometriosis; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Receptors, Transforming Growth Factor beta; Smad3 Protein; Transforming Growth Factor beta | 2022 |
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling.
Topics: Activins; Animals; Fibrosis; Mice; Renal Insufficiency, Chronic; Transforming Growth Factor beta | 2023 |
Activin and BMP Signalling in Human Testicular Cancer Cell Lines, and a Role for the Nucleocytoplasmic Transport Protein Importin-5 in Their Crosstalk.
Topics: Active Transport, Cell Nucleus; Activins; Animals; beta Karyopherins; Cell Line; Humans; Karyopherins; Male; Mice; Neoplasms, Germ Cell and Embryonal; Seminoma; Testicular Neoplasms; Transforming Growth Factor beta | 2023 |
KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
Topics: Activins; Animals; Cell Line, Tumor; Cell Plasticity; Humans; Mice; MicroRNAs; Pancreatic Neoplasms; Transforming Growth Factor beta | 2023 |
The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2.
Topics: Activins; Animals; Cell Differentiation; Cell Lineage; Human Embryonic Stem Cells; Humans; Mice; Muscular Dystrophies; Transforming Growth Factor beta; Zinc Finger E-box Binding Homeobox 2; Zinc Finger E-box-Binding Homeobox 1 | 2023 |
BRD9-mediated control of the TGF-β/Activin/Nodal pathway regulates self-renewal and differentiation of human embryonic stem cells and progression of cancer cells.
Topics: Activins; Cell Cycle Proteins; Cell Differentiation; Embryonic Stem Cells; Human Embryonic Stem Cells; Humans; Neoplasms; Nuclear Proteins; Transcription Factors; Transforming Growth Factor beta; Wnt Signaling Pathway | 2023 |