actinophyllic-acid and pyrroline

actinophyllic-acid has been researched along with pyrroline* in 1 studies

Other Studies

1 other study(ies) available for actinophyllic-acid and pyrroline

ArticleYear
Catalytic Asymmetric Total Synthesis of (-)-Actinophyllic Acid.
    Journal of the American Chemical Society, 2016, Mar-16, Volume: 138, Issue:10

    Described herein is a catalytic asymmetric total synthesis of (-)-actinophyllic acid, with the key step being a chiral phosphine-catalyzed [3 + 2] annulation between an imine and an allenoate to form a pyrroline intermediate in 99% yield and 94% ee. The synthesis also features CuI-catalyzed coupling between a ketoester and a 2-iodoindole to shape the tetrahydroazocine ring; intramolecular alkylative lactonization; SmI2-mediated intramolecular pinacol coupling between ketone and lactone subunits to assemble the complex skeleton of (-)-actinophyllic acid; and an unprecedented regioselective dehydroxylation.

    Topics: Catalysis; Copper; Imines; Indole Alkaloids; Oxidation-Reduction; Phosphines; Pyrroles; Stereoisomerism

2016